SIMILAR PATTERNS OF AMINO ACIDS FOR 2EUF_B_LQQB401_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1h4l CELL DIVISION
PROTEIN KINASE 5

(Homo sapiens) 		PF00069
(Pkinase) 		9 ILE A  10
VAL A  18
LYS A  33
VAL A  64
PHE A  80
ASP A  86
ASN A 131
LEU A 133
ALA A 143
 None
 0.89A 2eufB-1h4lA:
31.2		 2eufB-1h4lA:
45.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 ILE A 201
VAL A 209
LYS A 222
VAL A 249
ASN A 319
LEU A 321
ASP A 332
 None
 0.81A 2eufB-1k9aA:
25.5		 2eufB-1k9aA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		9 ILE A 580
VAL A 588
LYS A 608
VAL A 638
PHE A 654
ASP A 661
ASN A 729
LEU A 731
ALA A 741
 None
 0.87A 2eufB-1lufA:
23.8		 2eufB-1lufA:
27.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		8 ILE A 580
VAL A 638
PHE A 654
ASP A 661
ASN A 729
LEU A 731
ALA A 741
ASP A 742
 None
 0.85A 2eufB-1lufA:
23.8		 2eufB-1lufA:
27.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1m2p CASEIN KINASE II,
ALPHA CHAIN

(Zea mays) 		PF00069
(Pkinase) 		6 VAL A  53
LYS A  68
VAL A  95
PHE A 113
ASN A 161
ASP A 175
 HNA  A 351 (-4.5A)
HNA  A 351 (-2.6A)
None
HNA  A 351 (-3.6A)
None
HNA  A 351 (-3.3A)
 0.53A 2eufB-1m2pA:
30.6		 2eufB-1m2pA:
30.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		7 VAL A 172
LYS A 187
PHE A 246
ASN A 299
LEU A 301
ALA A 549
ASP A 550
 ADP  A 810 (-4.1A)
ADP  A 810 (-3.1A)
None
MG  A 809 ( 3.0A)
ADP  A 810 (-4.7A)
None
ADP  A 810 ( 3.0A)
 0.64A 2eufB-1q8yA:
29.2		 2eufB-1q8yA:
28.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjb FL CYTOKINE RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 624
LYS A 644
VAL A 675
PHE A 691
ASP A 698
ASN A 816
LEU A 818
ASP A 829
 None
 0.91A 2eufB-1rjbA:
22.4		 2eufB-1rjbA:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 603
LYS A 623
VAL A 654
ASP A 677
ASN A 797
LEU A 799
 STI  A   3 ( 4.6A)
STI  A   3 (-3.7A)
STI  A   3 (-4.3A)
None
None
STI  A   3 (-4.4A)
 0.61A 2eufB-1t46A:
18.8		 2eufB-1t46A:
26.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 ILE A  34
VAL A  42
LYS A  57
ASN A 156
LEU A 158
ASP A 169
 None
 0.63A 2eufB-1u5qA:
27.1		 2eufB-1u5qA:
28.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1v0b CELL DIVISION
CONTROL PROTEIN 2
HOMOLOG

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		7 ILE A  10
VAL A  18
LYS A  32
VAL A  63
PHE A  79
ASN A 130
LEU A 132
 None
 1.14A 2eufB-1v0bA:
29.0		 2eufB-1v0bA:
45.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1v0b CELL DIVISION
CONTROL PROTEIN 2
HOMOLOG

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		8 VAL A  18
LYS A  32
VAL A  63
PHE A  79
ASP A  85
ASN A 130
LEU A 132
ALA A 142
 None
 0.97A 2eufB-1v0bA:
29.0		 2eufB-1v0bA:
45.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zrz PROTEIN KINASE C,
IOTA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		8 VAL A 259
LYS A 274
VAL A 307
VAL A 326
ASP A 330
ASN A 374
LEU A 376
ASP A 387
 BI1  A1000 (-4.2A)
BI1  A1000 (-3.5A)
BI1  A1000 (-4.4A)
BI1  A1000 (-3.9A)
BI1  A1000 (-4.3A)
None
BI1  A1000 (-4.8A)
BI1  A1000 (-4.5A)
 0.94A 2eufB-1zrzA:
25.8		 2eufB-1zrzA:
27.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL X  25
LYS X  39
VAL X  67
ASN X 135
LEU X 137
ALA X 147
ASP X 148
 STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
None
STU  X 902 ( 4.9A)
STU  X 902 (-4.4A)
STU  X 902 ( 4.1A)
STU  X 902 (-3.6A)
 0.62A 2eufB-2dq7X:
26.8		 2eufB-2dq7X:
24.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A 170
LYS A 186
VAL A 220
PHE A 236
ASN A 288
LEU A 290
ALA A 319
ASP A 320
 None
 0.64A 2eufB-2eu9A:
30.3		 2eufB-2eu9A:
31.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 256
LYS A 271
VAL A 299
ASN A 368
LEU A 370
ALA A 380
ASP A 381
 GIN  A 600 ( 4.7A)
GIN  A 600 (-3.6A)
GIN  A 600 (-4.6A)
None
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-4.9A)
 0.69A 2eufB-2hz0A:
25.6		 2eufB-2hz0A:
26.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jgz CELL DIVISION
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		8 ILE A  10
VAL A  18
VAL A  64
PHE A  80
ASN A 132
LEU A 134
ALA A 144
ASP A 145
 None
 0.84A 2eufB-2jgzA:
36.0		 2eufB-2jgzA:
49.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jgz CELL DIVISION
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A  18
VAL A  64
PHE A  80
ASP A  86
ASN A 132
LEU A 134
ALA A 144
ASP A 145
 None
 0.66A 2eufB-2jgzA:
36.0		 2eufB-2jgzA:
49.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		6 VAL A  33
LYS A  48
PHE A 103
ASN A 154
LEU A 156
ASP A 167
 ATP  A 381 (-4.1A)
ATP  A 381 (-3.2A)
None
MN  A 383 ( 2.7A)
ATP  A 381 ( 4.8A)
MN  A 382 (-2.0A)
 0.59A 2eufB-2phkA:
22.0		 2eufB-2phkA:
30.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		8 ILE A  82
VAL A  90
LYS A 105
VAL A 137
ASP A 160
ASN A 203
LEU A 205
ALA A 215
 None
None
ANP  A1480 (-3.4A)
ANP  A1480 (-4.7A)
ANP  A1480 (-4.0A)
MG  A1481 (-3.5A)
ANP  A1480 ( 4.7A)
ANP  A1480 ( 4.1A)
 0.89A 2eufB-2v55A:
24.1		 2eufB-2v55A:
25.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LYS A 105
VAL A 137
ASP A 160
ASN A 203
LEU A 205
ALA A 215
ASP A 216
 ANP  A1480 (-3.4A)
ANP  A1480 (-4.7A)
ANP  A1480 (-4.0A)
MG  A1481 (-3.5A)
ANP  A1480 ( 4.7A)
ANP  A1480 ( 4.1A)
ANP  A1480 (-3.5A)
 0.84A 2eufB-2v55A:
24.1		 2eufB-2v55A:
25.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd5 DMPK PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A  85
LYS A 100
ASP A 155
THR A 158
ASN A 200
LEU A 202
ALA A 212
ASP A 213
 BI8  A1417 ( 4.7A)
BI8  A1417 (-4.2A)
None
None
BI8  A1417 (-3.6A)
BI8  A1417 (-4.8A)
BI8  A1417 ( 4.1A)
BI8  A1417 (-3.8A)
 0.82A 2eufB-2vd5A:
25.3		 2eufB-2vd5A:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN

(Homo sapiens) 		PF12330
(Haspin_kinase) 		8 ILE A 490
VAL A 498
LYS A 511
PHE A 605
ASP A 611
ASN A 654
LEU A 656
ASP A 687
 None
5ID  A1800 ( 4.5A)
IOD  A1799 (-3.2A)
5ID  A1800 (-4.1A)
5ID  A1800 (-3.6A)
None
5ID  A1800 (-4.5A)
IOD  A1799 (-4.0A)
 0.72A 2eufB-2vuwA:
13.1		 2eufB-2vuwA:
24.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2w9f CELL DIVISION
PROTEIN KINASE 4

(Homo sapiens) 		PF00069
(Pkinase) 		8 ILE B  12
VAL B  20
VAL B  72
PHE B  93
VAL B  96
THR B 102
LEU B 147
ALA B 157
 None
 0.92A 2eufB-2w9fB:
27.7		 2eufB-2w9fB:
69.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2w9f CELL DIVISION
PROTEIN KINASE 4

(Homo sapiens) 		PF00069
(Pkinase) 		9 VAL B  20
VAL B  72
PHE B  93
VAL B  96
ASP B  99
THR B 102
ASN B 145
LEU B 147
ALA B 157
 None
 0.80A 2eufB-2w9fB:
27.7		 2eufB-2w9fB:
69.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A  76
LYS A  94
VAL A 125
ASP A 148
THR A 151
ASN A 192
LEU A 194
ASP A 205
 None
STU  A   1 (-2.8A)
None
STU  A   1 (-3.8A)
None
STU  A   1 (-4.3A)
STU  A   1 (-4.6A)
STU  A   1 ( 3.8A)
 0.77A 2eufB-2z7rA:
24.4		 2eufB-2z7rA:
29.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3bhh CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II BETA
CHAIN

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  28
PHE A  90
VAL A  93
ASN A 141
LEU A 143
ALA A 156
ASP A 157
 5CP  A 600 ( 4.4A)
5CP  A 600 ( 4.3A)
5CP  A 600 ( 3.7A)
None
5CP  A 600 (-4.4A)
5CP  A 600 ( 3.9A)
5CP  A 600 (-3.5A)
 0.74A 2eufB-3bhhA:
27.4		 2eufB-3bhhA:
31.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3bhh CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II BETA
CHAIN

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  28
VAL A  74
PHE A  90
ASN A 141
LEU A 143
ALA A 156
ASP A 157
 5CP  A 600 ( 4.4A)
5CP  A 600 ( 4.7A)
5CP  A 600 ( 4.3A)
None
5CP  A 600 (-4.4A)
5CP  A 600 ( 3.9A)
5CP  A 600 (-3.5A)
 0.62A 2eufB-3bhhA:
27.4		 2eufB-3bhhA:
31.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo sapiens) 		PF00069
(Pkinase) 		6 ILE A  18
VAL A  26
LYS A  41
VAL A  75
PHE A  91
LEU A 148
 3AM  A 338 (-4.5A)
3AM  A 338 ( 4.1A)
3AM  A 338 (-2.9A)
None
3AM  A 338 (-3.6A)
3AM  A 338 (-4.7A)
 0.56A 2eufB-3c0iA:
21.7		 2eufB-3c0iA:
28.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ILE A 201
VAL A 209
LYS A 222
VAL A 249
ASN A 319
LEU A 321
ASP A 332
 None
 0.81A 2eufB-3d7uA:
26.3		 2eufB-3d7uA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  52
LYS A  67
ASP A 128
ASN A 172
LEU A 174
ASP A 186
 985  A   1 (-4.5A)
985  A   1 ( 2.8A)
985  A   1 (-4.7A)
985  A   1 (-4.6A)
985  A   1 (-4.8A)
985  A   1 ( 4.0A)
 0.61A 2eufB-3f2aA:
26.7		 2eufB-3f2aA:
27.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kl8 CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE II

(Caenorhabditis
elegans) 		PF00069
(Pkinase) 		6 VAL A  73
VAL A  92
ASN A 140
LEU A 142
ALA A 155
ASP A 156
 None
 0.67A 2eufB-3kl8A:
27.0		 2eufB-3kl8A:
31.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llt SERINE/THREONINE
KINASE-1, PFLAMMER

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		7 VAL A 566
LYS A 581
VAL A 614
PHE A 630
ASN A 682
LEU A 684
ASP A 720
 ANP  A 877 (-4.1A)
ANP  A 877 (-2.7A)
None
None
ANP  A 877 ( 4.8A)
None
ANP  A 877 (-2.9A)
 0.88A 2eufB-3lltA:
29.2		 2eufB-3lltA:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		7 ILE A 210
VAL A 218
LYS A 231
ASN A 337
LEU A 339
ALA A 349
ASP A 350
 LDN  A   1 (-4.1A)
LDN  A   1 ( 4.8A)
None
LDN  A   1 (-4.3A)
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
LDN  A   1 (-3.9A)
 0.84A 2eufB-3mdyA:
26.7		 2eufB-3mdyA:
28.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mi9 CELL DIVISION
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		10 ILE A  25
VAL A  33
LYS A  48
VAL A  79
PHE A 103
ASP A 109
ASN A 154
LEU A 156
ALA A 166
ASP A 167
 None
 0.81A 2eufB-3mi9A:
31.7		 2eufB-3mi9A:
37.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mtl CELL DIVISION
PROTEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A 179
LYS A 194
VAL A 224
PHE A 240
ASP A 246
ASN A 291
LEU A 293
ALA A 303
 FEF  A 668 (-4.9A)
None
FEF  A 668 (-4.7A)
FEF  A 668 ( 4.3A)
FEF  A 668 ( 4.3A)
FEF  A 668 (-3.9A)
FEF  A 668 (-4.2A)
FEF  A 668 ( 4.0A)
 0.76A 2eufB-3mtlA:
29.6		 2eufB-3mtlA:
40.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  57
LYS A  72
VAL A 104
VAL A 123
ASN A 171
LEU A 173
ASP A 184
 XFE  A 351 ( 4.5A)
None
None
XFE  A 351 (-4.2A)
None
XFE  A 351 (-4.6A)
None
 0.68A 2eufB-3mvjA:
26.4		 2eufB-3mvjA:
25.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3niz RHODANESE FAMILY
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		7 VAL A  37
LYS A  51
VAL A  82
PHE A  98
ASN A 149
ALA A 161
ASP A 162
 ADP  A 314 (-4.0A)
ADP  A 314 (-2.8A)
None
None
MG  A 312 ( 2.9A)
None
MG  A 312 ( 3.3A)
 0.74A 2eufB-3nizA:
31.4		 2eufB-3nizA:
45.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3niz RHODANESE FAMILY
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		7 VAL A  37
VAL A  82
ASP A 104
ASN A 149
LEU A 151
ALA A 161
ASP A 162
 ADP  A 314 (-4.0A)
None
ADP  A 314 (-4.1A)
MG  A 312 ( 2.9A)
ADP  A 314 (-4.6A)
None
MG  A 312 ( 3.3A)
 0.85A 2eufB-3nizA:
31.4		 2eufB-3nizA:
45.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		6 VAL A 200
VAL A 247
ASP A 270
ASN A 316
LEU A 318
ASP A 329
 AMP  A 577 (-4.3A)
None
AMP  A 577 (-3.6A)
AMP  A 577 (-4.2A)
AMP  A 577 (-4.8A)
AMP  A 577 (-4.0A)
 0.66A 2eufB-3nyoA:
27.5		 2eufB-3nyoA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		7 ILE A 557
VAL A 565
LYS A 578
VAL A 609
ASN A 681
LEU A 683
ASP A 694
 STU  A   1 (-4.1A)
STU  A   1 (-4.9A)
STU  A   1 (-3.5A)
None
STU  A   1 (-4.6A)
STU  A   1 (-4.3A)
STU  A   1 (-3.5A)
 0.89A 2eufB-3ppzA:
27.8		 2eufB-3ppzA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfv CDC42BPB PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		9 ILE A  82
VAL A  90
LYS A 105
ASP A 160
THR A 163
ASN A 205
LEU A 207
ALA A 217
ASP A 218
 None
NM7  A 416 (-3.7A)
EDO  A 417 (-3.5A)
None
None
None
NM7  A 416 ( 4.2A)
NM7  A 416 ( 4.5A)
EDO  A 417 (-3.7A)
 0.78A 2eufB-3qfvA:
24.5		 2eufB-3qfvA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3she MAP KINASE-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  58
LYS A  73
VAL A  98
ASN A 171
LEU A 173
ASP A 187
 I85  A 350 (-4.9A)
I85  A 350 (-2.8A)
None
I85  A 350 (-4.4A)
None
I85  A 350 (-3.3A)
 0.66A 2eufB-3sheA:
21.5		 2eufB-3sheA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		8 VAL A 369
LYS A 384
VAL A 436
ASP A 440
ASN A 484
LEU A 486
ALA A 496
ASP A 497
 07U  A   1 (-4.8A)
07U  A   1 (-3.0A)
07U  A   1 (-3.8A)
07U  A   1 (-3.9A)
None
07U  A   1 (-4.3A)
07U  A   1 ( 4.0A)
07U  A   1 (-3.6A)
 0.66A 2eufB-3txoA:
23.1		 2eufB-3txoA:
26.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zdu CYCLIN-DEPENDENT
KINASE-LIKE 3

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  18
LYS A  33
VAL A  63
PHE A  79
ASN A 130
LEU A 132
ASP A 143
 38R  A 350 ( 4.8A)
38R  A 350 (-2.9A)
38R  A 350 ( 4.9A)
38R  A 350 (-4.1A)
38R  A 350 (-4.2A)
38R  A 350 (-4.3A)
NA  A 353 ( 2.5A)
 0.60A 2eufB-3zduA:
29.7		 2eufB-3zduA:
35.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1

(Homo sapiens) 		PF00069
(Pkinase) 		8 ILE A  10
VAL A  18
LYS A  33
VAL A  64
PHE A  80
ASN A 131
LEU A 133
ASP A 144
 D15  A 500 (-4.2A)
D15  A 500 (-4.6A)
D15  A 500 ( 4.1A)
None
D15  A 500 ( 4.3A)
D15  A 500 (-3.0A)
D15  A 500 (-4.5A)
D15  A 500 (-3.7A)
 0.79A 2eufB-4aguA:
31.9		 2eufB-4aguA:
36.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 ILE A  83
VAL A  91
LYS A 106
ASN A 206
LEU A 208
ALA A 218
ASP A 219
 None
None
EDO  A1419 (-3.3A)
None
EDO  A1420 ( 4.8A)
None
None
 0.68A 2eufB-4aw2A:
24.5		 2eufB-4aw2A:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		8 VAL A  91
LYS A 106
ASP A 161
THR A 164
ASN A 206
LEU A 208
ALA A 218
ASP A 219
 None
EDO  A1419 (-3.3A)
None
None
None
EDO  A1420 ( 4.8A)
None
None
 0.62A 2eufB-4aw2A:
24.5		 2eufB-4aw2A:
24.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bbm CYCLIN-DEPENDENT
KINASE-LIKE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  18
VAL A  64
PHE A  80
VAL A  83
ASN A 131
LEU A 133
ASP A 144
 None
TC0  A 500 (-4.7A)
TC0  A 500 (-3.4A)
TC0  A 500 (-4.4A)
None
TC0  A 500 (-4.3A)
TC0  A 500 (-4.8A)
 0.56A 2eufB-4bbmA:
27.0		 2eufB-4bbmA:
35.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bgq CYCLIN-DEPENDENT
KINASE-LIKE 5

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  27
LYS A  42
VAL A  73
PHE A  89
VAL A  92
LEU A 142
 38R  A1000 ( 4.8A)
38R  A1000 (-3.4A)
None
38R  A1000 ( 3.8A)
38R  A1000 (-4.1A)
38R  A1000 ( 4.5A)
 0.44A 2eufB-4bgqA:
30.6		 2eufB-4bgqA:
35.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		7 VAL A  30
LYS A  45
VAL A  96
ASN A 144
LEU A 146
ALA A 156
ASP A 157
 None
STU  A1550 (-3.6A)
STU  A1550 (-3.8A)
STU  A1550 (-4.3A)
STU  A1550 (-4.3A)
STU  A1550 ( 3.8A)
STU  A1550 (-3.6A)
 0.66A 2eufB-4cfhA:
29.4		 2eufB-4cfhA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		8 VAL A 671
LYS A 686
VAL A 721
ASP A 744
ASN A 787
LEU A 789
ALA A 799
ASP A 800
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.0A)
None
AGS  A1985 (-4.0A)
MG  A1986 ( 3.2A)
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
AGS  A1985 ( 3.3A)
 0.63A 2eufB-4crsA:
27.1		 2eufB-4crsA:
26.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ez5 CYCLIN-DEPENDENT
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		12 ILE A  19
VAL A  27
LYS A  43
VAL A  77
PHE A  98
VAL A 101
ASP A 104
THR A 107
ASN A 150
LEU A 152
ALA A 162
ASP A 163
 0RS  A 900 (-4.1A)
None
0RS  A 900 (-3.3A)
0RS  A 900 (-4.4A)
0RS  A 900 (-4.5A)
0RS  A 900 (-4.5A)
0RS  A 900 (-4.2A)
0RS  A 900 (-4.2A)
None
0RS  A 900 (-4.3A)
0RS  A 900 (-3.6A)
0RS  A 900 (-3.6A)
 0.95A 2eufB-4ez5A:
32.3		 2eufB-4ez5A:
98.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ez5 CYCLIN-DEPENDENT
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		9 VAL A  27
LYS A  43
VAL A  77
PHE A  98
VAL A 101
ASP A 104
THR A 106
LEU A 152
ALA A 162
 None
0RS  A 900 (-3.3A)
0RS  A 900 (-4.4A)
0RS  A 900 (-4.5A)
0RS  A 900 (-4.5A)
0RS  A 900 (-4.2A)
None
0RS  A 900 (-4.3A)
0RS  A 900 (-3.6A)
 1.39A 2eufB-4ez5A:
32.3		 2eufB-4ez5A:
98.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fr4 SERINE/THREONINE-PRO
TEIN KINASE 32A

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  29
VAL A  37
VAL A  84
ASP A 107
ASN A 151
LEU A 153
ASP A 164
 STU  A 401 (-4.1A)
STU  A 401 ( 4.9A)
None
STU  A 401 (-3.3A)
STU  A 401 ( 4.8A)
STU  A 401 (-4.7A)
STU  A 401 ( 3.9A)
 0.76A 2eufB-4fr4A:
26.2		 2eufB-4fr4A:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 836
LYS A 855
VAL A 884
ASN A 954
LEU A 956
ALA A 966
ASP A 967
 19S  A1201 (-4.4A)
19S  A1201 (-3.5A)
None
None
19S  A1201 (-4.5A)
19S  A1201 ( 4.1A)
19S  A1201 ( 4.1A)
 0.60A 2eufB-4hviA:
26.3		 2eufB-4hviA:
25.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idt MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 14

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A 414
LYS A 429
VAL A 453
ASN A 520
LEU A 522
ASP A 534
 T28  A 701 (-4.7A)
T28  A 701 ( 3.8A)
None
T28  A 701 ( 4.9A)
T28  A 701 (-3.9A)
T28  A 701 ( 3.4A)
 0.64A 2eufB-4idtA:
25.1		 2eufB-4idtA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jr7 CASEIN KINASE II
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		6 VAL A  54
LYS A  69
PHE A 152
VAL A 155
ASN A 200
ASP A 214
 GNP  A 401 (-4.2A)
GNP  A 401 (-3.3A)
None
GNP  A 401 (-4.0A)
MG  A 402 ( 2.6A)
GNP  A 401 ( 2.7A)
 0.50A 2eufB-4jr7A:
29.2		 2eufB-4jr7A:
28.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A  50
LYS A  63
VAL A  90
ASN A 161
LEU A 163
ASP A 175
 1UL  A 501 ( 4.9A)
None
None
None
1UL  A 501 (-4.3A)
1UL  A 501 (-4.2A)
 0.62A 2eufB-4l52A:
18.1		 2eufB-4l52A:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oav PROTEIN (RNASE L)

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		7 ILE B 371
LYS B 392
VAL B 418
ASN B 490
LEU B 492
ALA B 502
ASP B 503
 ACP  B 801 (-4.2A)
ACP  B 801 (-2.8A)
None
MG  B 802 ( 2.5A)
ACP  B 801 (-4.5A)
None
MG  B 803 (-1.8A)
 0.81A 2eufB-4oavB:
19.6		 2eufB-4oavB:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otd SERINE/THREONINE-PRO
TEIN KINASE N1

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		8 VAL A 635
LYS A 650
VAL A 685
ASP A 708
ASN A 751
LEU A 753
ALA A 763
ASP A 764
 None
 0.85A 2eufB-4otdA:
26.5		 2eufB-4otdA:
27.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		7 VAL A  32
LYS A  47
VAL A  98
ASN A 146
LEU A 148
ALA A 158
ASP A 159
 STU  A 601 ( 4.8A)
STU  A 601 ( 3.7A)
STU  A 601 (-4.1A)
STU  A 601 (-4.2A)
STU  A 601 (-4.2A)
STU  A 601 ( 3.8A)
STU  A 601 (-3.7A)
 0.65A 2eufB-4rewA:
28.3		 2eufB-4rewA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LYS A 644
VAL A 675
PHE A 691
ASP A 698
ASN A 816
LEU A 818
ASP A 829
 P30  A1001 (-3.4A)
None
P30  A1001 (-3.7A)
None
None
P30  A1001 (-4.6A)
None
 0.89A 2eufB-4rt7A:
18.8		 2eufB-4rt7A:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 624
LYS A 644
VAL A 675
PHE A 691
ASP A 698
ASN A 816
LEU A 818
 None
P30  A1001 (-3.4A)
None
P30  A1001 (-3.7A)
None
None
P30  A1001 (-4.6A)
 0.71A 2eufB-4rt7A:
18.8		 2eufB-4rt7A:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		7 VAL A 112
LYS A 127
VAL A 159
VAL A 178
ASN A 226
LEU A 228
ASP A 239
 ATP  A 501 (-4.0A)
ATP  A 501 (-2.6A)
None
ATP  A 501 (-4.2A)
ZN  A 502 ( 2.5A)
ATP  A 501 (-4.5A)
ZN  A 503 (-1.9A)
 0.69A 2eufB-4wb7A:
26.8		 2eufB-4wb7A:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 VAL A 201
LYS A 216
VAL A 248
ASP A 271
ASN A 319
LEU A 321
ASP A 332
 None
None
None
None
None
ANW  A 601 (-4.9A)
None
 0.89A 2eufB-4wboA:
27.2		 2eufB-4wboA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 624
LYS A 644
VAL A 675
PHE A 691
ASP A 698
ASN A 816
LEU A 818
 P30  A1001 ( 4.8A)
P30  A1001 ( 4.0A)
None
P30  A1001 ( 4.3A)
None
None
P30  A1001 (-4.3A)
 0.78A 2eufB-4xufA:
17.4		 2eufB-4xufA:
28.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yc6 CYCLIN-DEPENDENT
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  18
VAL A  64
PHE A  80
ASP A  86
ASN A 133
LEU A 135
ALA A 145
 None
 0.85A 2eufB-4yc6A:
29.8		 2eufB-4yc6A:
46.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ILE A 469
VAL A 477
LYS A 490
ASN A 593
LEU A 595
ALA A 605
ASP A 606
 4CV  A 801 (-4.3A)
None
4CV  A 801 (-3.9A)
None
4CV  A 801 (-4.4A)
4CV  A 801 ( 3.9A)
4CV  A 801 (-3.5A)
 0.61A 2eufB-4yffA:
23.5		 2eufB-4yffA:
27.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ylj DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 1A

(Homo sapiens) 		PF00069
(Pkinase) 		8 ILE A 165
VAL A 173
LYS A 188
VAL A 222
PHE A 238
ASN A 292
LEU A 294
ASP A 307
 4E1  A 505 ( 4.6A)
4E1  A 505 (-4.5A)
4E1  A 505 (-2.7A)
None
4E1  A 505 (-4.2A)
None
None
4E1  A 505 (-3.6A)
 0.69A 2eufB-4yljA:
30.7		 2eufB-4yljA:
29.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  30
VAL A  76
ASP A  99
ASN A 143
LEU A 145
ALA A 164
 51W  A 401 ( 4.3A)
None
51W  A 401 (-3.8A)
GOL  A 404 ( 4.6A)
51W  A 401 (-4.5A)
None
 0.49A 2eufB-5ci7A:
27.1		 2eufB-5ci7A:
29.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		7 VAL A  70
LYS A  85
VAL A 116
ASN A 183
LEU A 185
ALA A 195
ASP A 196
 5RC  A4000 (-4.6A)
5RC  A4000 (-2.8A)
None
5RC  A4000 (-4.1A)
None
5RC  A4000 ( 3.9A)
5RC  A4000 (-3.6A)
 0.76A 2eufB-5es1A:
26.1		 2eufB-5es1A:
27.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 911
LYS A 930
VAL A 981
ASN A1028
LEU A1030
ASP A1041
 5U3  A1200 ( 4.4A)
None
5U3  A1200 (-3.5A)
5U3  A1200 (-4.7A)
5U3  A1200 (-4.4A)
5U3  A1200 ( 4.9A)
 0.60A 2eufB-5f1zA:
20.7		 2eufB-5f1zA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 607
LYS A 627
VAL A 658
ASP A 681
ASN A 823
LEU A 825
 748  A1001 ( 4.7A)
748  A1001 (-4.0A)
748  A1001 ( 4.8A)
None
None
748  A1001 (-4.3A)
 0.60A 2eufB-5grnA:
11.1		 2eufB-5grnA:
26.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		9 VAL A  28
LYS A  43
VAL A  74
PHE A  90
VAL A  93
ASN A 141
LEU A 143
ALA A 156
ASP A 157
 ADP  A 301 (-3.7A)
ADP  A 301 (-2.7A)
None
None
ADP  A 301 (-4.0A)
MG  A 302 ( 2.8A)
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.8A)
MG  A 302 ( 3.3A)
 0.68A 2eufB-5hu3A:
29.4		 2eufB-5hu3A:
31.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5idn CYCLIN-DEPENDENT
KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		7 LYS A  52
PHE A  97
ASP A 103
ASN A 156
LEU A 158
ALA A 172
ASP A 173
 6A7  A 401 ( 2.9A)
6A7  A 401 (-3.8A)
6A7  A 401 ( 4.9A)
FMT  A 403 ( 4.7A)
6A7  A 401 (-4.8A)
6A7  A 401 ( 4.1A)
FMT  A 403 ( 3.3A)
 1.00A 2eufB-5idnA:
22.1		 2eufB-5idnA:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5idn CYCLIN-DEPENDENT
KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  35
LYS A  52
PHE A  97
ASP A 103
LEU A 158
ALA A 172
ASP A 173
 6A7  A 401 ( 4.5A)
6A7  A 401 ( 2.9A)
6A7  A 401 (-3.8A)
6A7  A 401 ( 4.9A)
6A7  A 401 (-4.8A)
6A7  A 401 ( 4.1A)
FMT  A 403 ( 3.3A)
 0.85A 2eufB-5idnA:
22.1		 2eufB-5idnA:
33.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta) 		PF00069
(Pkinase) 		7 ILE A  24
VAL A  32
LYS A  47
VAL A  78
PHE A  94
LEU A 147
ASP A 161
 None
 1.00A 2eufB-5ig1A:
27.7		 2eufB-5ig1A:
26.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		7 VAL A  30
LYS A  45
VAL A  96
ASN A 144
LEU A 146
ALA A 156
ASP A 157
 STU  A 601 (-4.8A)
STU  A 601 ( 4.4A)
STU  A 601 (-4.0A)
STU  A 601 (-4.3A)
STU  A 601 (-4.5A)
STU  A 601 (-3.5A)
STU  A 601 (-3.5A)
 0.66A 2eufB-5isoA:
28.5		 2eufB-5isoA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		8 ILE A  22
VAL A  30
LYS A  45
VAL A  74
ASN A 141
LEU A 143
ALA A 153
ASP A 154
 6G2  A 901 (-3.8A)
6G2  A 901 ( 4.9A)
6G2  A 901 ( 3.9A)
None
None
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
6G2  A 901 (-3.4A)
 0.69A 2eufB-5j5tA:
24.1		 2eufB-5j5tA:
27.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 404
VAL A 449
VAL A 468
ASP A 472
ASN A 516
LEU A 518
ASP A 533
 GUI  A 701 (-4.4A)
None
GUI  A 701 (-4.0A)
None
GUI  A 701 (-4.4A)
GUI  A 701 (-4.4A)
GUI  A 701 ( 4.8A)
 0.74A 2eufB-5jznA:
27.4		 2eufB-5jznA:
32.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		6 VAL A 897
LYS A 911
VAL A 940
ASN A1014
LEU A1016
ASP A1027
 ATP  A1200 ( 4.5A)
ATP  A1200 (-3.8A)
None
ATP  A1200 (-3.6A)
ATP  A1200 (-4.6A)
ATP  A1200 (-4.1A)
 0.66A 2eufB-5lpyA:
24.4		 2eufB-5lpyA:
27.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A 155
VAL A 163
LYS A 178
PHE A 228
ASN A 280
LEU A 282
ASP A 295
 7A7  A 501 ( 4.3A)
7A7  A 501 (-4.4A)
7A7  A 501 (-3.5A)
7A7  A 501 (-3.7A)
7A7  A 501 ( 4.8A)
7A7  A 501 (-4.9A)
7A7  A 501 (-3.2A)
 0.56A 2eufB-5lxdA:
30.4		 2eufB-5lxdA:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mov CASEIN KINASE II
SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  53
LYS A  68
PHE A 113
VAL A 116
ASN A 161
ASP A 175
 None
HC4  A 401 (-2.7A)
HC4  A 401 (-3.4A)
None
None
HC4  A 401 (-4.0A)
 0.61A 2eufB-5movA:
30.0		 2eufB-5movA:
29.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncl SERINE/THREONINE-PRO
TEIN KINASE CBK1

(Saccharomyces
cerevisiae) 		no annotation 7 ILE A 358
VAL A 366
VAL A 413
ASP A 436
THR A 439
ASN A 480
LEU A 482
 ANP  A 801 (-4.2A)
ANP  A 801 (-4.7A)
ANP  A 801 ( 4.9A)
ANP  A 801 (-3.4A)
None
ANP  A 801 (-3.8A)
ANP  A 801 (-4.8A)
 0.82A 2eufB-5nclA:
21.2		 2eufB-5nclA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		no annotation 6 VAL A  52
LYS A  67
ASP A 128
ASN A 172
LEU A 174
ASP A 186
 7LK  A 401 (-4.9A)
None
7LK  A 401 ( 3.9A)
None
7LK  A 401 (-4.8A)
None
 0.58A 2eufB-5turA:
26.5		 2eufB-5turA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A 106
LYS A 121
VAL A 153
ASP A 176
ASN A 219
LEU A 221
ALA A 231
ASP A 232
 None
 0.73A 2eufB-5u7qA:
24.8		 2eufB-5u7qA:
26.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		no annotation 7 VAL A 694
LYS A 709
VAL A 738
VAL A 757
ASN A 808
LEU A 810
ASP A 822
 9E1  A1001 ( 4.0A)
9E1  A1001 (-2.8A)
9E1  A1001 (-4.1A)
9E1  A1001 (-3.9A)
9E1  A1001 ( 4.0A)
9E1  A1001 (-4.5A)
9E1  A1001 (-3.6A)
 0.50A 2eufB-5vilA:
20.2		 2eufB-5vilA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y86 DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 3

(Homo sapiens) 		no annotation 7 ILE A 215
VAL A 223
LYS A 238
PHE A 288
ASN A 340
LEU A 342
ASP A 355
 None
HRM  A 601 ( 4.9A)
HRM  A 601 (-3.3A)
HRM  A 601 (-3.6A)
None
None
HRM  A 601 (-4.7A)
 0.75A 2eufB-5y86A:
30.1		 2eufB-5y86A:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y86 DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 3

(Homo sapiens) 		no annotation 7 VAL A 223
LYS A 238
PHE A 288
ASP A 294
ASN A 340
LEU A 342
ASP A 355
 HRM  A 601 ( 4.9A)
HRM  A 601 (-3.3A)
HRM  A 601 (-3.6A)
None
None
None
HRM  A 601 (-4.7A)
 0.59A 2eufB-5y86A:
30.1		 2eufB-5y86A:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3e CYCLIN-DEPENDENT
KINASE 12

(Homo sapiens) 		no annotation 10 ILE A 733
VAL A 741
LYS A 756
VAL A 787
PHE A 813
ASP A 819
ASN A 864
LEU A 866
ALA A 876
ASP A 877
 CJM  A1102 (-3.4A)
None
None
None
CJM  A1102 ( 4.4A)
CJM  A1102 (-4.1A)
MG  A1101 ( 4.4A)
CJM  A1102 (-4.4A)
CJM  A1102 (-3.6A)
MG  A1101 (-2.5A)
 0.76A 2eufB-6b3eA:
34.4		 2eufB-6b3eA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bql CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 7 ILE A 171
VAL A 179
LYS A 194
VAL A 249
PHE A 267
VAL A 270
LEU A 319
 BI9  A 501 (-4.0A)
BI9  A 501 ( 4.8A)
NH4  A 506 ( 4.4A)
None
BI9  A 501 ( 4.2A)
BI9  A 501 (-4.0A)
BI9  A 501 (-4.7A)
 0.87A 2eufB-6bqlA:
27.1		 2eufB-6bqlA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bql CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 8 VAL A 179
LYS A 194
VAL A 249
PHE A 267
VAL A 270
ASN A 317
LEU A 319
ALA A 329
 BI9  A 501 ( 4.8A)
NH4  A 506 ( 4.4A)
None
BI9  A 501 ( 4.2A)
BI9  A 501 (-4.0A)
BI9  A 501 (-4.5A)
BI9  A 501 (-4.7A)
NH4  A 506 ( 3.7A)
 0.93A 2eufB-6bqlA:
27.1		 2eufB-6bqlA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bql CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 7 VAL A 249
PHE A 267
VAL A 270
ASN A 317
LEU A 319
ALA A 329
ASP A 330
 None
BI9  A 501 ( 4.2A)
BI9  A 501 (-4.0A)
BI9  A 501 (-4.5A)
BI9  A 501 (-4.7A)
NH4  A 506 ( 3.7A)
None
 0.84A 2eufB-6bqlA:
27.1		 2eufB-6bqlA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 8 ILE A  66
VAL A  74
LYS A  89
VAL A 120
ASN A 187
LEU A 189
ALA A 199
ASP A 200
 None
 0.82A 2eufB-6c9dA:
27.5		 2eufB-6c9dA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccf CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 1

(Homo sapiens) 		no annotation 8 VAL A 142
LYS A 157
VAL A 212
PHE A 230
ASN A 280
LEU A 282
ALA A 292
ASP A 293
 H1N  A 501 (-4.4A)
H1N  A 501 (-2.8A)
H1N  A 501 (-4.9A)
H1N  A 501 (-3.7A)
H1N  A 501 (-4.5A)
H1N  A 501 (-4.8A)
H1N  A 501 ( 3.9A)
H1N  A 501 (-3.5A)
 0.65A 2eufB-6ccfA:
26.3		 2eufB-6ccfA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmj CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 10 ILE A 171
VAL A 179
LYS A 194
VAL A 249
PHE A 267
VAL A 270
ASN A 317
LEU A 319
ALA A 329
ASP A 330
 F6J  A 501 (-4.3A)
F6J  A 501 (-4.6A)
F6J  A 501 (-2.9A)
None
F6J  A 501 (-3.7A)
F6J  A 501 (-4.0A)
F6J  A 501 ( 4.7A)
F6J  A 501 (-4.5A)
F6J  A 501 ( 4.0A)
F6J  A 501 (-3.8A)
 0.76A 2eufB-6cmjA:
27.4		 2eufB-6cmjA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdy -

(-) 		no annotation 6 VAL U  75
ASP U  98
ASN U 142
LEU U 144
ALA U 156
ASP U 157
 DB8  U 301 (-4.8A)
None
DB8  U 301 (-4.5A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.2A)
DB8  U 301 (-3.6A)
 0.54A 2eufB-6fdyU:
26.7		 2eufB-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 7 VAL A 177
LYS A 193
VAL A 227
PHE A 243
ASN A 295
LEU A 297
ASP A 327
 3NG  A 501 ( 4.4A)
3NG  A 501 (-3.0A)
None
3NG  A 501 (-3.5A)
None
None
3NG  A 501 (-4.5A)
 0.86A 2eufB-6fylA:
30.4		 2eufB-6fylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1

(Homo sapiens) 		no annotation 7 VAL A 175
LYS A 191
VAL A 225
PHE A 241
ASN A 293
LEU A 295
ASP A 325
 None
EAQ  A 501 (-3.2A)
None
EAQ  A 501 (-3.5A)
None
EAQ  A 501 (-4.9A)
EAQ  A 501 (-4.6A)
 0.66A 2eufB-6fyoA:
31.1		 2eufB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 7 VAL A 175
LYS A 191
VAL A 225
PHE A 241
ASN A 293
LEU A 295
ASP A 325
 3NG  A 501 ( 4.3A)
3NG  A 501 (-2.7A)
None
3NG  A 501 (-3.5A)
None
None
3NG  A 501 (-4.3A)
 0.68A 2eufB-6fyvA:
31.3		 2eufB-6fyvA:
undetectable