SIMILAR PATTERNS OF AMINO ACIDS FOR 2EJT_A_SAMA501_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aor ALDEHYDE FERREDOXIN
OXIDOREDUCTASE

(Pyrococcus
furiosus) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		5 ALA A 109
ILE A   9
ASN A   4
SER A  34
ALA A  28
 None
 1.21A 2ejtA-1aorA:
undetectable		 2ejtA-1aorA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fht U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN A

(Homo sapiens) 		PF00076
(RRM_1) 		5 ASP A  89
ALA A  54
ILE A  83
ALA A  64
PHE A  58
 None
 1.13A 2ejtA-1fhtA:
undetectable		 2ejtA-1fhtA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hcu ALPHA-1,2-MANNOSIDAS
E

(Trichoderma
reesei) 		PF01532
(Glyco_hydro_47) 		5 LEU A 115
ILE A  77
SER A 122
ASP A  63
PHE A 481
 None
 1.23A 2ejtA-1hcuA:
undetectable		 2ejtA-1hcuA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1imv PIGMENT
EPITHELIUM-DERIVED
FACTOR

(Homo sapiens) 		PF00079
(Serpin) 		5 LEU A  72
ALA A  68
ILE A  84
ALA A  76
PHE A 323
 None
 1.23A 2ejtA-1imvA:
undetectable		 2ejtA-1imvA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obg PHOSPHORIBOSYLAMIDOI
MIDAZOLE-
SUCCINOCARBOXAMIDE
SYNTHASE

(Saccharomyces
cerevisiae) 		PF01259
(SAICAR_synt) 		5 ILE A 125
ARG A 122
ALA A 195
ASP A 215
PHE A 218
 None
SO4  A 308 (-2.9A)
None
SO4  A 308 ( 4.5A)
None
 1.10A 2ejtA-1obgA:
undetectable		 2ejtA-1obgA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1psq PROBABLE THIOL
PEROXIDASE

(Streptococcus
pneumoniae) 		PF08534
(Redoxin) 		5 LEU A  72
ALA A  70
ILE A 157
ALA A 160
ASP A  73
 None
 0.97A 2ejtA-1psqA:
undetectable		 2ejtA-1psqA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pv9 XAA-PRO DIPEPTIDASE

(Pyrococcus
furiosus) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		5 LEU A 210
ALA A 177
ILE A 139
ALA A 143
ASP A 209
 None
None
None
None
ZN  A 402 (-2.2A)
 1.23A 2ejtA-1pv9A:
undetectable		 2ejtA-1pv9A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qjc PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Escherichia
coli) 		PF01467
(CTP_transf_like) 		5 LEU A  54
ALA A  58
ALA A 153
PHE A  11
PHE A  46
 None
 1.04A 2ejtA-1qjcA:
4.0		 2ejtA-1qjcA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6b CLPA PROTEIN

(Escherichia
coli) 		PF00004
(AAA)
PF02861
(Clp_N)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		5 LEU X 176
ASN X 177
ILE X 281
SER X 280
ALA X 228
 None
 1.12A 2ejtA-1r6bX:
undetectable		 2ejtA-1r6bX:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tuf DIAMINOPIMELATE
DECARBOXYLASE

(Methanocaldococcus
jannaschii) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 ASP A 283
LEU A 281
ALA A  64
ASP A 280
PHE A 235
 None
 1.17A 2ejtA-1tufA:
undetectable		 2ejtA-1tufA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ufw SYNAPTOJANIN 2

(Homo sapiens) 		PF08952
(DUF1866) 		5 ILE A  89
SER A  90
ALA A  71
ASP A  15
PHE A  65
 None
 1.11A 2ejtA-1ufwA:
undetectable		 2ejtA-1ufwA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ug3 EUKARYOTIC PROTEIN
SYNTHESIS INITIATION
FACTOR 4G

(Homo sapiens) 		PF02020
(W2)
PF02847
(MA3) 		5 LEU A1526
ALA A1528
ALA A1560
PHE A1546
PHE A1561
 None
 1.06A 2ejtA-1ug3A:
undetectable		 2ejtA-1ug3A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4p ALANYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		no annotation 5 ASP A  47
LEU A 144
ALA A  27
ARG A  48
ILE A  43
 None
 1.18A 2ejtA-1v4pA:
undetectable		 2ejtA-1v4pA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xb7 STEROID HORMONE
RECEPTOR ERR1

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 451
ALA A 429
ARG A 448
ALA A 454
PHE A 345
PHE A 286
 None
 1.29A 2ejtA-1xb7A:
undetectable		 2ejtA-1xb7A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
LIKE 2

(Homo sapiens) 		PF00160
(Pro_isomerase) 		5 LEU A 390
ALA A 388
ILE A 396
SER A 359
PHE A 381
 None
 1.24A 2ejtA-1zkcA:
undetectable		 2ejtA-1zkcA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2av9 THIOESTERASE

(Pseudomonas
aeruginosa) 		PF03061
(4HBT) 		5 ASP A  24
ALA A  38
ILE A  18
ARG A  21
ASN A  32
 None
 1.10A 2ejtA-2av9A:
undetectable		 2ejtA-2av9A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 701
ALA A 699
ASN A 705
SER A 888
PHE A 876
 None
None
BHM  A   1 (-3.6A)
None
None
 1.19A 2ejtA-2ax9A:
undetectable		 2ejtA-2ax9A:
21.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dul N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE

(Pyrococcus
horikoshii) 		PF02005
(TRM) 		6 ASP A  53
ILE A  63
ASN A  77
ILE A  79
SER A  80
ALA A 121
 None
 1.31A 2ejtA-2dulA:
62.9		 2ejtA-2dulA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dul N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE

(Pyrococcus
horikoshii) 		PF02005
(TRM) 		11 ASP A  53
LEU A  55
ALA A  57
ILE A  60
ARG A  61
ASN A  77
ILE A  79
SER A  80
ALA A 121
ASP A 138
PHE A 146
 None
 0.20A 2ejtA-2dulA:
62.9		 2ejtA-2dulA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dul N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE

(Pyrococcus
horikoshii) 		PF02005
(TRM) 		6 ILE A  63
ASN A  77
ILE A  79
SER A  80
ALA A 121
PHE A  27
 None
 1.17A 2ejtA-2dulA:
62.9		 2ejtA-2dulA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqd BLUE COPPER OXIDASE
CUEO

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 ARG A 232
ILE A 324
SER A 325
ALA A 226
ASP A 180
 None
 1.15A 2ejtA-2fqdA:
undetectable		 2ejtA-2fqdA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuk XC6422 PROTEIN

(Xanthomonas
campestris) 		PF12146
(Hydrolase_4) 		5 ALA A 141
ILE A 168
ILE A 138
SER A 139
ALA A  61
 None
 1.13A 2ejtA-2fukA:
undetectable		 2ejtA-2fukA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kno TENSIN-LIKE C1
DOMAIN-CONTAINING
PHOSPHATASE

(Homo sapiens) 		PF00017
(SH2) 		5 ALA A  59
ILE A  33
ARG A  29
ILE A  86
ALA A  55
 None
 1.18A 2ejtA-2knoA:
undetectable		 2ejtA-2knoA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2no5 (S)-2-HALOACID
DEHALOGENASE IVA

(Burkholderia
cepacia) 		PF13419
(HAD_2) 		5 LEU A 143
ALA A 145
ILE A 150
ILE A 117
ALA A 116
 None
 1.24A 2ejtA-2no5A:
undetectable		 2ejtA-2no5A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oby PUTATIVE QUINONE
OXIDOREDUCTASE

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ALA A  38
ILE A 326
SER A  66
ALA A  96
ASP A  43
 None
 1.20A 2ejtA-2obyA:
8.5		 2ejtA-2obyA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p18 GLYOXALASE II

(Leishmania
infantum) 		PF00753
(Lactamase_B)
PF16123
(HAGH_C) 		5 ASP A 135
ALA A 107
ILE A 111
SER A 110
ASP A 122
 None
 1.16A 2ejtA-2p18A:
undetectable		 2ejtA-2p18A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2poz PUTATIVE DEHYDRATASE

(Mesorhizobium
japonicum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ALA A 241
ARG A 175
ILE A 253
SER A 246
ASP A 235
 None
 1.20A 2ejtA-2pozA:
2.0		 2ejtA-2pozA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q14 PHOSPHOHYDROLASE

(Bacteroides
thetaiotaomicron) 		PF01966
(HD) 		5 LEU A 151
ALA A  87
ILE A 139
ILE A  70
PHE A 150
 None
 1.06A 2ejtA-2q14A:
undetectable		 2ejtA-2q14A:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qve TYROSINE AMINOMUTASE

(Streptomyces
globisporus) 		PF00221
(Lyase_aromatic) 		5 LEU A 213
ALA A 108
ARG A 220
SER A 208
ALA A 452
 None
 1.25A 2ejtA-2qveA:
undetectable		 2ejtA-2qveA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wte CSA3

(Sulfolobus
solfataricus) 		no annotation 5 ILE A  46
ILE A  90
SER A  91
ALA A  24
PHE A  14
 None
 1.20A 2ejtA-2wteA:
3.7		 2ejtA-2wteA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwu IMPORTIN13

(Homo sapiens) 		PF03810
(IBN_N)
PF08389
(Xpo1) 		5 ALA B 248
ARG B 219
ILE B 263
ALA B 262
PHE B 226
 None
 1.19A 2ejtA-2xwuB:
undetectable		 2ejtA-2xwuB:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ygk NURA

(Sulfolobus
solfataricus) 		PF09376
(NurA) 		5 ILE A  57
ILE A 108
SER A 109
ALA A  73
ASP A  92
 None
 1.15A 2ejtA-2ygkA:
undetectable		 2ejtA-2ygkA:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026

(Methanocaldococcus
jannaschii) 		PF01189
(Methyltr_RsmB-F) 		5 ASP A  89
ALA A  93
ILE A 116
SER A 117
ASP A 163
 SFG  A 500 ( 4.4A)
SFG  A 500 (-3.7A)
SFG  A 500 (-3.7A)
None
SFG  A 500 (-3.7A)
 0.82A 2ejtA-3a4tA:
11.4		 2ejtA-3a4tA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3acp WD REPEAT-CONTAINING
PROTEIN YGL004C

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		5 ARG A  72
ALA A   8
ASP A  77
PHE A 372
PHE A 377
 None
 1.21A 2ejtA-3acpA:
undetectable		 2ejtA-3acpA:
21.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3axs PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1

(Aquifex
aeolicus) 		PF02005
(TRM) 		5 ASP A  58
ILE A  68
ASN A  83
ILE A  85
ALA A 114
 SFG  A 501 ( 4.6A)
None
SFG  A 501 ( 4.7A)
SFG  A 501 (-3.7A)
SFG  A 501 (-3.6A)
 1.18A 2ejtA-3axsA:
44.3		 2ejtA-3axsA:
38.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3axs PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1

(Aquifex
aeolicus) 		PF02005
(TRM) 		11 ASP A  58
LEU A  60
ALA A  62
ILE A  65
ARG A  66
ASN A  83
ILE A  85
SER A  86
ALA A 114
ASP A 132
PHE A 140
 SFG  A 501 ( 4.6A)
SFG  A 501 (-3.7A)
SFG  A 501 (-3.4A)
None
SFG  A 501 (-4.3A)
SFG  A 501 ( 4.7A)
SFG  A 501 (-3.7A)
SFG  A 501 ( 4.7A)
SFG  A 501 (-3.6A)
SFG  A 501 (-3.7A)
None
 0.50A 2ejtA-3axsA:
44.3		 2ejtA-3axsA:
38.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Homo sapiens) 		PF16113
(ECH_2) 		5 LEU A 202
ALA A 166
ILE A 142
ALA A 210
PHE A 259
 None
 0.93A 2ejtA-3bptA:
undetectable		 2ejtA-3bptA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cq5 HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Corynebacterium
glutamicum) 		PF00155
(Aminotran_1_2) 		5 ASP A 276
LEU A  45
ALA A  44
ALA A 270
PHE A 232
 None
 1.23A 2ejtA-3cq5A:
3.8		 2ejtA-3cq5A:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d02 PUTATIVE LACI-TYPE
TRANSCRIPTIONAL
REGULATOR

(Klebsiella
pneumoniae) 		PF13407
(Peripla_BP_4) 		5 ILE A 130
ILE A  34
SER A  35
ASP A 127
PHE A 103
 None
None
CL  A   1 (-3.0A)
None
None
 1.13A 2ejtA-3d02A:
3.6		 2ejtA-3d02A:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6n DIHYDROOROTASE
ASPARTATE
CARBAMOYLTRANSFERASE

(Aquifex
aeolicus;
Aquifex
aeolicus) 		PF01979
(Amidohydro_1)
PF00185
(OTCace)
PF02729
(OTCace_N) 		5 LEU A 200
ALA A 198
ILE B 155
ILE A 191
PHE B 103
 None
 1.23A 2ejtA-3d6nA:
undetectable		 2ejtA-3d6nA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dd4 KV
CHANNEL-INTERACTING
PROTEIN 4

(Mus musculus) 		PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		5 LEU A 146
ILE A 209
ASN A 145
ILE A 149
ALA A 110
 None
 1.21A 2ejtA-3dd4A:
undetectable		 2ejtA-3dd4A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddu PROLYL ENDOPEPTIDASE

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		5 LEU A 634
ALA A 576
ILE A 550
ILE A 672
SER A 649
 None
 1.15A 2ejtA-3dduA:
undetectable		 2ejtA-3dduA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcj NITROALKANE OXIDASE

(Fusarium
oxysporum) 		PF00441
(Acyl-CoA_dh_1)
PF02771
(Acyl-CoA_dh_N) 		5 LEU A  99
ALA A 129
ILE A  58
ALA A 272
PHE A 273
 NIE  A 600 ( 4.9A)
None
None
None
GOL  A 700 (-4.1A)
 1.24A 2ejtA-3fcjA:
undetectable		 2ejtA-3fcjA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3flo DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A

(Saccharomyces
cerevisiae) 		PF08996
(zf-DNA_Pol) 		5 ASP B1451
LEU B1449
ASN B1450
SER B1443
PHE B1392
 None
 1.17A 2ejtA-3floB:
undetectable		 2ejtA-3floB:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fs2 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Brucella
melitensis) 		PF00793
(DAHP_synth_1) 		5 ARG A 135
ASN A 138
ASP A 112
PHE A  92
PHE A  15
 None
 1.03A 2ejtA-3fs2A:
undetectable		 2ejtA-3fs2A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7q VALINE-PYRUVATE
AMINOTRANSFERASE

(Salmonella
enterica) 		PF00155
(Aminotran_1_2) 		5 LEU A 215
ILE A 261
ASN A 240
ILE A 213
ALA A 208
 None
 1.13A 2ejtA-3g7qA:
undetectable		 2ejtA-3g7qA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gi8 UNCHARACTERIZED
PROTEIN MJ0609

(Methanocaldococcus
jannaschii) 		PF13520
(AA_permease_2) 		5 LEU C  41
ILE C 191
ILE C 244
ALA C 240
PHE C  30
 None
 1.22A 2ejtA-3gi8C:
undetectable		 2ejtA-3gi8C:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gi8 UNCHARACTERIZED
PROTEIN MJ0609

(Methanocaldococcus
jannaschii) 		PF13520
(AA_permease_2) 		5 LEU C 103
ALA C 105
ILE C 125
ALA C  24
PHE C 334
 None
 1.21A 2ejtA-3gi8C:
undetectable		 2ejtA-3gi8C:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hi8 PROLIFERATING CELL
NUCLEAR ANTIGEN PCNA

(Haloferax
volcanii) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		5 LEU A  11
ALA A  82
ILE A 101
ALA A  77
ASP A  13
 None
 1.07A 2ejtA-3hi8A:
undetectable		 2ejtA-3hi8A:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hxw ALANYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF01411
(tRNA-synt_2c) 		5 LEU A 293
ALA A 291
ILE A 312
ASP A 296
PHE A  38
 None
 1.23A 2ejtA-3hxwA:
undetectable		 2ejtA-3hxwA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5p NUCLEOPORIN NUP170

(Saccharomyces
cerevisiae) 		PF03177
(Nucleoporin_C) 		5 ALA A1221
ILE A1301
ILE A1216
ALA A1214
PHE A1242
 None
 1.17A 2ejtA-3i5pA:
undetectable		 2ejtA-3i5pA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nd6 PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Enterococcus
faecalis) 		PF01467
(CTP_transf_like) 		5 LEU A  54
ALA A  58
ALA A 154
PHE A  11
PHE A  46
 None
 1.04A 2ejtA-3nd6A:
undetectable		 2ejtA-3nd6A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ne7 ACETYLTRANSFERASE

(Thermoplasma
acidophilum) 		PF00583
(Acetyltransf_1) 		5 LEU A  16
SER A  46
ALA A  20
ASP A  12
PHE A  77
 None
 1.19A 2ejtA-3ne7A:
undetectable		 2ejtA-3ne7A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pmq DECAHEME CYTOCHROME
C MTRF

(Shewanella
oneidensis) 		no annotation 5 LEU A 366
ARG A 367
ALA A 325
ASP A 365
PHE A 323
 None
 1.23A 2ejtA-3pmqA:
undetectable		 2ejtA-3pmqA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pmq DECAHEME CYTOCHROME
C MTRF

(Shewanella
oneidensis) 		no annotation 5 LEU A 366
ARG A 367
SER A 356
ALA A 325
ASP A 365
 None
 1.08A 2ejtA-3pmqA:
undetectable		 2ejtA-3pmqA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qh6 CT296

(Chlamydia
trachomatis) 		PF16802
(DUF5070) 		5 LEU A 113
ALA A 143
ILE A 102
SER A 116
ALA A  25
 None
 1.21A 2ejtA-3qh6A:
undetectable		 2ejtA-3qh6A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rza TRIPEPTIDASE

(Staphylococcus
aureus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 ASP A 167
ILE A 346
ILE A 148
SER A 145
ALA A 150
 ZN  A 401 (-2.2A)
None
None
None
None
 1.24A 2ejtA-3rzaA:
undetectable		 2ejtA-3rzaA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5n PUTATIVE
RHAMNOSIDASE

(Streptomyces
avermitilis) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		5 LEU A 542
ALA A 540
ARG A 543
ALA A 547
PHE A 914
 None
 1.23A 2ejtA-3w5nA:
undetectable		 2ejtA-3w5nA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wp8 TRIMERIC
AUTOTRANSPORTER
ADHESIN

(Acinetobacter
sp. Tol 5) 		PF05658
(YadA_head)
PF05662
(YadA_stalk) 		5 ALA A3029
ILE A3042
ASN A3023
ILE A3005
ALA A3007
 None
 1.14A 2ejtA-3wp8A:
undetectable		 2ejtA-3wp8A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zid TUBULIN/FTSZ, GTPASE

(Methanothrix
thermoacetophila) 		PF00091
(Tubulin) 		5 LEU A  17
ILE A 193
ASN A  14
ALA A  47
PHE A 107
 None
GDP  A 999 (-3.5A)
None
None
None
 1.15A 2ejtA-3zidA:
2.5		 2ejtA-3zidA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3u NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE

(Zymomonas
mobilis) 		PF00724
(Oxidored_FMN) 		5 LEU A 225
ILE A 231
ILE A 281
SER A 278
ALA A 246
 None
 1.13A 2ejtA-4a3uA:
undetectable		 2ejtA-4a3uA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1n IRON-SULFUR CLUSTER
BINDING PROTEIN

(Carboxydothermus
hydrogenoformans) 		PF14574
(DUF4445) 		5 LEU I 510
ILE I 468
ASN I 509
ALA I 402
PHE I 403
 None
None
B12  I1631 (-4.2A)
None
None
 1.21A 2ejtA-4c1nI:
undetectable		 2ejtA-4c1nI:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1o HISTIDINE
DECARBOXYLASE

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		5 LEU A 419
ALA A 471
ILE A 467
ASN A 422
SER A 476
 None
 1.22A 2ejtA-4e1oA:
2.9		 2ejtA-4e1oA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eff AROMATIC-AMINO-ACID
AMINOTRANSFERASE

(Burkholderia
pseudomallei) 		PF00155
(Aminotran_1_2) 		5 ASP A 190
LEU A 191
ALA A 229
ASN A 192
PHE A 161
 None
 1.22A 2ejtA-4effA:
undetectable		 2ejtA-4effA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E

(Linum
nodiflorum) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		5 ASP A 247
ASN A 245
ILE A 225
SER A 202
ALA A 219
 None
 1.19A 2ejtA-4eviA:
8.2		 2ejtA-4eviA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		5 ASP A 179
ALA A 183
ASN A 203
SER A 206
ASP A 255
 SAM  A 401 ( 4.2A)
SAM  A 401 (-4.1A)
SAM  A 401 ( 4.6A)
SAM  A 401 (-4.8A)
SAM  A 401 (-3.7A)
 0.90A 2ejtA-4fzvA:
11.6		 2ejtA-4fzvA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1u HEMIN TRANSPORT
SYSTEM PERMEASE
PROTEIN HMUU

(Yersinia pestis) 		PF01032
(FecCD) 		5 LEU A  69
ILE A 268
ILE A 247
ALA A 250
PHE A 259
 None
 1.07A 2ejtA-4g1uA:
undetectable		 2ejtA-4g1uA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzu PREDICTED MEMBRANE
PROTEIN
ENERGY-COUPLING
FACTOR TRANSPORTER
TRANSMEMBRANE
PROTEIN ECFT

(Lactobacillus
brevis;
Lactobacillus
brevis) 		PF07155
(ECF-ribofla_trS)
PF02361
(CbiQ) 		5 LEU T 165
ALA S  17
ARG T 166
SER S  63
ALA T 137
 None
 1.11A 2ejtA-4hzuT:
undetectable		 2ejtA-4hzuT:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jig DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF13561
(adh_short_C2) 		5 LEU A 247
ALA A 245
ARG A 191
ALA A 230
ASP A 248
 None
 1.24A 2ejtA-4jigA:
4.4		 2ejtA-4jigA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1

(Physcomitrella
patens) 		PF01156
(IU_nuc_hydro) 		5 LEU A 144
ALA A 148
ILE A 164
ALA A 140
ASP A 188
 None
 1.24A 2ejtA-4kpnA:
2.8		 2ejtA-4kpnA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpo NUCLEOSIDE
N-RIBOHYDROLASE 3

(Zea mays) 		PF01156
(IU_nuc_hydro) 		5 LEU A 126
ALA A 130
ILE A 146
ALA A 122
ASP A 170
 None
 1.20A 2ejtA-4kpoA:
2.8		 2ejtA-4kpoA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l60 PROLIFERATING CELL
NUCLEAR ANTIGEN

(Saccharomyces
cerevisiae) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		5 LEU A 236
ALA A 235
ILE A 160
ILE A 128
PHE A 248
 None
 1.19A 2ejtA-4l60A:
undetectable		 2ejtA-4l60A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lrs 4-HYDROXY-2-OXOVALER
ATE ALDOLASE

(Thermomonospora
curvata) 		PF00682
(HMGL-like)
PF07836
(DmpG_comm) 		5 LEU A  92
ALA A  90
ILE A  51
ILE A 116
ALA A 117
 None
None
None
None
PYR  A 402 ( 4.7A)
 1.22A 2ejtA-4lrsA:
undetectable		 2ejtA-4lrsA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE

(Eggerthella
lenta) 		PF00905
(Transpeptidase) 		5 LEU A 254
ALA A 251
SER A 280
ALA A 258
PHE A 184
 None
 1.20A 2ejtA-4mnrA:
undetectable		 2ejtA-4mnrA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Methanocaldococcus
jannaschii) 		PF02350
(Epimerase_2) 		5 LEU A 120
ILE A 131
ASN A 153
ALA A 150
ASP A  95
 None
None
None
None
UD1  A 400 ( 4.8A)
 1.16A 2ejtA-4nesA:
undetectable		 2ejtA-4nesA:
25.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oc9 PUTATIVE
O-ACETYLHOMOSERINE
(THIOL)-LYASE

(Campylobacter
jejuni) 		PF01053
(Cys_Met_Meta_PP) 		5 ASP A 241
LEU A 249
ALA A 236
ASN A 248
PHE A 257
 None
 1.16A 2ejtA-4oc9A:
undetectable		 2ejtA-4oc9A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		5 LEU A 214
ILE A 205
SER A 201
ALA A 208
ASP A 217
 None
 1.15A 2ejtA-4rewA:
undetectable		 2ejtA-4rewA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rpf HOMOSERINE KINASE

(Yersinia pestis) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 LEU A  20
ILE A 161
ILE A  10
SER A   9
PHE A  17
 None
 1.18A 2ejtA-4rpfA:
undetectable		 2ejtA-4rpfA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y2w ALANINE RACEMASE 1

(Caldanaerobacter
subterraneus) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 ALA A 170
ILE A 206
SER A 167
ALA A 211
ASP A 176
 None
 1.17A 2ejtA-4y2wA:
undetectable		 2ejtA-4y2wA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7e LMO1422 PROTEIN

(Listeria
monocytogenes) 		PF04069
(OpuAC) 		5 LEU A 414
ALA A 342
ARG A 403
ASN A 413
PHE A 392
 None
 1.22A 2ejtA-4z7eA:
undetectable		 2ejtA-4z7eA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
ALPHA

(Methanothermobacter
marburgensis) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		5 ALA A 290
ILE A 511
ILE A 310
SER A 306
ALA A 314
 None
 1.17A 2ejtA-5a8rA:
undetectable		 2ejtA-5a8rA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyx PROTEIN CDHR2

(Mus musculus) 		PF00028
(Cadherin) 		5 ASP A  18
LEU A  19
ARG A  97
SER A  63
ALA A  23
 None
 1.07A 2ejtA-5cyxA:
undetectable		 2ejtA-5cyxA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czr CADHERIN-RELATED
FAMILY MEMBER 2

(Homo sapiens) 		PF00028
(Cadherin) 		5 ASP A  18
LEU A  19
ARG A  97
SER A  63
ALA A  23
 None
 1.15A 2ejtA-5czrA:
undetectable		 2ejtA-5czrA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6b FUMARATE HYDRATASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		5 LEU A  99
ALA A  95
ILE A 201
ALA A 103
PHE A 191
 None
 1.21A 2ejtA-5d6bA:
undetectable		 2ejtA-5d6bA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f5p PROTEIN SHROOM2
RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens;
Homo sapiens) 		PF08687
(ASD2)
no annotation 		5 LEU A1501
ILE A1586
SER A1506
ALA C 848
PHE C 852
 None
None
None
None
CL  A1701 ( 4.5A)
 1.02A 2ejtA-5f5pA:
undetectable		 2ejtA-5f5pA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmq INFLUENZA A PB2
SUBUNIT

(Influenza A
virus) 		PF00604
(Flu_PB2) 		5 ASP A 671
LEU A 665
ALA A 674
ILE A 553
PHE A 656
 None
 0.99A 2ejtA-5fmqA:
undetectable		 2ejtA-5fmqA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5g PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT

(Escherichia
coli) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		5 LEU B 258
ALA B 245
ILE B 247
ALA B 303
PHE B 287
 None
None
IOD  B1317 ( 4.9A)
None
None
 1.23A 2ejtA-5g5gB:
undetectable		 2ejtA-5g5gB:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc8 ARACHIDONATE
15-LIPOXYGENASE

(Pseudomonas
aeruginosa) 		PF00305
(Lipoxygenase) 		5 ASP A 251
LEU A 283
ALA A 277
PHE A 317
PHE A 264
 None
 1.19A 2ejtA-5lc8A:
undetectable		 2ejtA-5lc8A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqm GLYCOSYL HYDROLASES
FAMILY 2, SUGAR
BINDING DOMAIN

(Bacteroides
thetaiotaomicron) 		PF17132
(Glyco_hydro_106) 		5 LEU A 839
ARG A 875
ILE A 845
ALA A 872
ASP A 838
 None
 1.23A 2ejtA-5mqmA:
undetectable		 2ejtA-5mqmA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwr TETR FAMILY
TRANSCRIPTIONAL
REGULATOR

(Sulfolobus
acidocaldarius) 		no annotation 5 ILE A  87
ILE A 159
SER A 155
ALA A 162
PHE A  97
 None
None
PTR  A 133 ( 3.4A)
None
None
 1.25A 2ejtA-5mwrA:
undetectable		 2ejtA-5mwrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ogz -

(-) 		no annotation 5 LEU A 401
ALA A  15
ILE A 353
SER A 354
PHE A 418
 None
 1.16A 2ejtA-5ogzA:
undetectable		 2ejtA-5ogzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u70 POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1

(Gallus gallus) 		PF03493
(BK_channel_a)
PF07885
(Ion_trans_2) 		5 LEU A 260
ILE A 252
ALA A 317
PHE A 262
PHE A 291
 None
 1.10A 2ejtA-5u70A:
4.5		 2ejtA-5u70A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		5 LEU B 253
ALA B 254
ALA B 314
ASP B 249
PHE B 316
 None
 1.23A 2ejtA-5w3jB:
2.2		 2ejtA-5w3jB:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7k OXAG

(Penicillium
oxalicum) 		no annotation 5 ASP A  52
ILE A  83
SER A  84
ALA A 110
PHE A 132
 None
SAH  A 301 (-3.9A)
None
SAH  A 301 (-3.4A)
SAH  A 301 (-4.6A)
 1.15A 2ejtA-5w7kA:
12.5		 2ejtA-5w7kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7m GLANDICOLINE B
O-METHYLTRANSFERASE
ROQN

(Penicillium
rubens) 		no annotation 5 ASP A  52
ILE A  83
SER A  84
ALA A 110
PHE A 132
 None
SAH  A 301 (-3.5A)
None
SAH  A 301 (-3.5A)
SAH  A 301 (-4.5A)
 1.21A 2ejtA-5w7mA:
12.6		 2ejtA-5w7mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wgg RADICAL SAM DOMAIN
PROTEIN
CTEA

(Ruminiclostridium
thermocellum;
Ruminiclostridium
thermocellum) 		PF04055
(Radical_SAM)
PF13186
(SPASM)
PF13353
(Fer4_12)
PF13165
(SCIFF) 		5 ALA A 447
ILE A 445
ASN B   8
ILE B   6
ALA A  22
 None
 1.21A 2ejtA-5wggA:
undetectable		 2ejtA-5wggA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194) 		5 LEU C3254
ALA C3246
ILE C3243
ALA C3006
PHE C3252
 None
 0.95A 2ejtA-5y3rC:
undetectable		 2ejtA-5y3rC:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byw GOXA

(Pseudoalteromonas
luteoviolacea) 		no annotation 5 LEU B 194
ILE B 597
ASN B 645
ALA B 642
ASP B 195
 None
 1.24A 2ejtA-6bywB:
undetectable		 2ejtA-6bywB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 5 ALA A 355
ARG A 426
ILE A 375
SER A 372
ASP A 401
 None
 1.17A 2ejtA-6cz4A:
undetectable		 2ejtA-6cz4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhs RUVB-LIKE HELICASE
INO80

(Chaetomium
thermophilum;
Chaetomium
thermophilum) 		no annotation
no annotation 		5 ASP A 245
LEU A 244
ARG A 118
SER G1309
ALA G1469
 None
 1.07A 2ejtA-6fhsA:
undetectable		 2ejtA-6fhsA:
undetectable