SIMILAR PATTERNS OF AMINO ACIDS FOR 2EJT_A_SAMA501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aor ALDEHYDE FERREDOXIN
OXIDOREDUCTASE

(Pyrococcus
furiosus) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		5 ALA A 109
ILE A   9
ASN A   4
SER A  34
ALA A  28
 None
 1.21A 2ejtA-1aorA:
undetectable		 2ejtA-1aorA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fht U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN A

(Homo sapiens) 		PF00076
(RRM_1) 		5 ASP A  89
ALA A  54
ILE A  83
ALA A  64
PHE A  58
 None
 1.13A 2ejtA-1fhtA:
undetectable		 2ejtA-1fhtA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hcu ALPHA-1,2-MANNOSIDAS
E

(Trichoderma
reesei) 		PF01532
(Glyco_hydro_47) 		5 LEU A 115
ILE A  77
SER A 122
ASP A  63
PHE A 481
 None
 1.23A 2ejtA-1hcuA:
undetectable		 2ejtA-1hcuA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1imv PIGMENT
EPITHELIUM-DERIVED
FACTOR

(Homo sapiens) 		PF00079
(Serpin) 		5 LEU A  72
ALA A  68
ILE A  84
ALA A  76
PHE A 323
 None
 1.23A 2ejtA-1imvA:
undetectable		 2ejtA-1imvA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obg PHOSPHORIBOSYLAMIDOI
MIDAZOLE-
SUCCINOCARBOXAMIDE
SYNTHASE

(Saccharomyces
cerevisiae) 		PF01259
(SAICAR_synt) 		5 ILE A 125
ARG A 122
ALA A 195
ASP A 215
PHE A 218
 None
SO4  A 308 (-2.9A)
None
SO4  A 308 ( 4.5A)
None
 1.10A 2ejtA-1obgA:
undetectable		 2ejtA-1obgA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1psq PROBABLE THIOL
PEROXIDASE

(Streptococcus
pneumoniae) 		PF08534
(Redoxin) 		5 LEU A  72
ALA A  70
ILE A 157
ALA A 160
ASP A  73
 None
 0.97A 2ejtA-1psqA:
undetectable		 2ejtA-1psqA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pv9 XAA-PRO DIPEPTIDASE

(Pyrococcus
furiosus) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		5 LEU A 210
ALA A 177
ILE A 139
ALA A 143
ASP A 209
 None
None
None
None
ZN  A 402 (-2.2A)
 1.23A 2ejtA-1pv9A:
undetectable		 2ejtA-1pv9A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qjc PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Escherichia
coli) 		PF01467
(CTP_transf_like) 		5 LEU A  54
ALA A  58
ALA A 153
PHE A  11
PHE A  46
 None
 1.04A 2ejtA-1qjcA:
4.0		 2ejtA-1qjcA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6b CLPA PROTEIN

(Escherichia
coli) 		PF00004
(AAA)
PF02861
(Clp_N)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		5 LEU X 176
ASN X 177
ILE X 281
SER X 280
ALA X 228
 None
 1.12A 2ejtA-1r6bX:
undetectable		 2ejtA-1r6bX:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tuf DIAMINOPIMELATE
DECARBOXYLASE

(Methanocaldococcus
jannaschii) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 ASP A 283
LEU A 281
ALA A  64
ASP A 280
PHE A 235
 None
 1.17A 2ejtA-1tufA:
undetectable		 2ejtA-1tufA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ufw SYNAPTOJANIN 2

(Homo sapiens) 		PF08952
(DUF1866) 		5 ILE A  89
SER A  90
ALA A  71
ASP A  15
PHE A  65
 None
 1.11A 2ejtA-1ufwA:
undetectable		 2ejtA-1ufwA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ug3 EUKARYOTIC PROTEIN
SYNTHESIS INITIATION
FACTOR 4G

(Homo sapiens) 		PF02020
(W2)
PF02847
(MA3) 		5 LEU A1526
ALA A1528
ALA A1560
PHE A1546
PHE A1561
 None
 1.06A 2ejtA-1ug3A:
undetectable		 2ejtA-1ug3A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4p ALANYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		no annotation 5 ASP A  47
LEU A 144
ALA A  27
ARG A  48
ILE A  43
 None
 1.18A 2ejtA-1v4pA:
undetectable		 2ejtA-1v4pA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xb7 STEROID HORMONE
RECEPTOR ERR1

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 451
ALA A 429
ARG A 448
ALA A 454
PHE A 345
PHE A 286
 None
 1.29A 2ejtA-1xb7A:
undetectable		 2ejtA-1xb7A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
LIKE 2

(Homo sapiens) 		PF00160
(Pro_isomerase) 		5 LEU A 390
ALA A 388
ILE A 396
SER A 359
PHE A 381
 None
 1.24A 2ejtA-1zkcA:
undetectable		 2ejtA-1zkcA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2av9 THIOESTERASE

(Pseudomonas
aeruginosa) 		PF03061
(4HBT) 		5 ASP A  24
ALA A  38
ILE A  18
ARG A  21
ASN A  32
 None
 1.10A 2ejtA-2av9A:
undetectable		 2ejtA-2av9A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 701
ALA A 699
ASN A 705
SER A 888
PHE A 876
 None
None
BHM  A   1 (-3.6A)
None
None
 1.19A 2ejtA-2ax9A:
undetectable		 2ejtA-2ax9A:
21.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dul N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE

(Pyrococcus
horikoshii) 		PF02005
(TRM) 		6 ASP A  53
ILE A  63
ASN A  77
ILE A  79
SER A  80
ALA A 121
 None
 1.31A 2ejtA-2dulA:
62.9		 2ejtA-2dulA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dul N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE

(Pyrococcus
horikoshii) 		PF02005
(TRM) 		11 ASP A  53
LEU A  55
ALA A  57
ILE A  60
ARG A  61
ASN A  77
ILE A  79
SER A  80
ALA A 121
ASP A 138
PHE A 146
 None
 0.20A 2ejtA-2dulA:
62.9		 2ejtA-2dulA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dul N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE

(Pyrococcus
horikoshii) 		PF02005
(TRM) 		6 ILE A  63
ASN A  77
ILE A  79
SER A  80
ALA A 121
PHE A  27
 None
 1.17A 2ejtA-2dulA:
62.9		 2ejtA-2dulA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqd BLUE COPPER OXIDASE
CUEO

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 ARG A 232
ILE A 324
SER A 325
ALA A 226
ASP A 180
 None
 1.15A 2ejtA-2fqdA:
undetectable		 2ejtA-2fqdA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuk XC6422 PROTEIN

(Xanthomonas
campestris) 		PF12146
(Hydrolase_4) 		5 ALA A 141
ILE A 168
ILE A 138
SER A 139
ALA A  61
 None
 1.13A 2ejtA-2fukA:
undetectable		 2ejtA-2fukA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kno TENSIN-LIKE C1
DOMAIN-CONTAINING
PHOSPHATASE

(Homo sapiens) 		PF00017
(SH2) 		5 ALA A  59
ILE A  33
ARG A  29
ILE A  86
ALA A  55
 None
 1.18A 2ejtA-2knoA:
undetectable		 2ejtA-2knoA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2no5 (S)-2-HALOACID
DEHALOGENASE IVA

(Burkholderia
cepacia) 		PF13419
(HAD_2) 		5 LEU A 143
ALA A 145
ILE A 150
ILE A 117
ALA A 116
 None
 1.24A 2ejtA-2no5A:
undetectable		 2ejtA-2no5A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oby PUTATIVE QUINONE
OXIDOREDUCTASE

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ALA A  38
ILE A 326
SER A  66
ALA A  96
ASP A  43
 None
 1.20A 2ejtA-2obyA:
8.5		 2ejtA-2obyA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p18 GLYOXALASE II

(Leishmania
infantum) 		PF00753
(Lactamase_B)
PF16123
(HAGH_C) 		5 ASP A 135
ALA A 107
ILE A 111
SER A 110
ASP A 122
 None
 1.16A 2ejtA-2p18A:
undetectable		 2ejtA-2p18A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2poz PUTATIVE DEHYDRATASE

(Mesorhizobium
japonicum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ALA A 241
ARG A 175
ILE A 253
SER A 246
ASP A 235
 None
 1.20A 2ejtA-2pozA:
2.0		 2ejtA-2pozA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q14 PHOSPHOHYDROLASE

(Bacteroides
thetaiotaomicron) 		PF01966
(HD) 		5 LEU A 151
ALA A  87
ILE A 139
ILE A  70
PHE A 150
 None
 1.06A 2ejtA-2q14A:
undetectable		 2ejtA-2q14A:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qve TYROSINE AMINOMUTASE

(Streptomyces
globisporus) 		PF00221
(Lyase_aromatic) 		5 LEU A 213
ALA A 108
ARG A 220
SER A 208
ALA A 452
 None
 1.25A 2ejtA-2qveA:
undetectable		 2ejtA-2qveA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wte CSA3

(Sulfolobus
solfataricus) 		no annotation 5 ILE A  46
ILE A  90
SER A  91
ALA A  24
PHE A  14
 None
 1.20A 2ejtA-2wteA:
3.7		 2ejtA-2wteA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwu IMPORTIN13

(Homo sapiens) 		PF03810
(IBN_N)
PF08389
(Xpo1) 		5 ALA B 248
ARG B 219
ILE B 263
ALA B 262
PHE B 226
 None
 1.19A 2ejtA-2xwuB:
undetectable		 2ejtA-2xwuB:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ygk NURA

(Sulfolobus
solfataricus) 		PF09376
(NurA) 		5 ILE A  57
ILE A 108
SER A 109
ALA A  73
ASP A  92
 None
 1.15A 2ejtA-2ygkA:
undetectable		 2ejtA-2ygkA:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a4t PUTATIVE
METHYLTRANSFERASE
MJ0026

(Methanocaldococcus
jannaschii) 		PF01189
(Methyltr_RsmB-F) 		5 ASP A  89
ALA A  93
ILE A 116
SER A 117
ASP A 163
 SFG  A 500 ( 4.4A)
SFG  A 500 (-3.7A)
SFG  A 500 (-3.7A)
None
SFG  A 500 (-3.7A)
 0.82A 2ejtA-3a4tA:
11.4		 2ejtA-3a4tA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3acp WD REPEAT-CONTAINING
PROTEIN YGL004C

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		5 ARG A  72
ALA A   8
ASP A  77
PHE A 372
PHE A 377
 None
 1.21A 2ejtA-3acpA:
undetectable		 2ejtA-3acpA:
21.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3axs PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1

(Aquifex
aeolicus) 		PF02005
(TRM) 		5 ASP A  58
ILE A  68
ASN A  83
ILE A  85
ALA A 114
 SFG  A 501 ( 4.6A)
None
SFG  A 501 ( 4.7A)
SFG  A 501 (-3.7A)
SFG  A 501 (-3.6A)
 1.18A 2ejtA-3axsA:
44.3		 2ejtA-3axsA:
38.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3axs PROBABLE
N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE
TRM1

(Aquifex
aeolicus) 		PF02005
(TRM) 		11 ASP A  58
LEU A  60
ALA A  62
ILE A  65
ARG A  66
ASN A  83
ILE A  85
SER A  86
ALA A 114
ASP A 132
PHE A 140
 SFG  A 501 ( 4.6A)
SFG  A 501 (-3.7A)
SFG  A 501 (-3.4A)
None
SFG  A 501 (-4.3A)
SFG  A 501 ( 4.7A)
SFG  A 501 (-3.7A)
SFG  A 501 ( 4.7A)
SFG  A 501 (-3.6A)
SFG  A 501 (-3.7A)
None
 0.50A 2ejtA-3axsA:
44.3		 2ejtA-3axsA:
38.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Homo sapiens) 		PF16113
(ECH_2) 		5 LEU A 202
ALA A 166
ILE A 142
ALA A 210
PHE A 259
 None
 0.93A 2ejtA-3bptA:
undetectable		 2ejtA-3bptA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cq5 HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Corynebacterium
glutamicum) 		PF00155
(Aminotran_1_2) 		5 ASP A 276
LEU A  45
ALA A  44
ALA A 270
PHE A 232
 None
 1.23A 2ejtA-3cq5A:
3.8		 2ejtA-3cq5A:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d02 PUTATIVE LACI-TYPE
TRANSCRIPTIONAL
REGULATOR

(Klebsiella
pneumoniae) 		PF13407
(Peripla_BP_4) 		5 ILE A 130
ILE A  34
SER A  35
ASP A 127
PHE A 103
 None
None
CL  A   1 (-3.0A)
None
None
 1.13A 2ejtA-3d02A:
3.6		 2ejtA-3d02A:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6n DIHYDROOROTASE
ASPARTATE
CARBAMOYLTRANSFERASE

(Aquifex
aeolicus;
Aquifex
aeolicus) 		PF01979
(Amidohydro_1)
PF00185
(OTCace)
PF02729
(OTCace_N) 		5 LEU A 200
ALA A 198
ILE B 155
ILE A 191
PHE B 103
 None
 1.23A 2ejtA-3d6nA:
undetectable		 2ejtA-3d6nA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dd4 KV
CHANNEL-INTERACTING
PROTEIN 4

(Mus musculus) 		PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		5 LEU A 146
ILE A 209
ASN A 145
ILE A 149
ALA A 110
 None
 1.21A 2ejtA-3dd4A:
undetectable		 2ejtA-3dd4A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddu PROLYL ENDOPEPTIDASE

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		5 LEU A 634
ALA A 576
ILE A 550
ILE A 672
SER A 649
 None
 1.15A 2ejtA-3dduA:
undetectable		 2ejtA-3dduA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcj NITROALKANE OXIDASE

(Fusarium
oxysporum) 		PF00441
(Acyl-CoA_dh_1)
PF02771
(Acyl-CoA_dh_N) 		5 LEU A  99
ALA A 129
ILE A  58
ALA A 272
PHE A 273
 NIE  A 600 ( 4.9A)
None
None
None
GOL  A 700 (-4.1A)
 1.24A 2ejtA-3fcjA:
undetectable		 2ejtA-3fcjA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3flo DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A

(Saccharomyces
cerevisiae) 		PF08996
(zf-DNA_Pol) 		5 ASP B1451
LEU B1449
ASN B1450
SER B1443
PHE B1392
 None
 1.17A 2ejtA-3floB:
undetectable		 2ejtA-3floB:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fs2 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Brucella
melitensis) 		PF00793
(DAHP_synth_1) 		5 ARG A 135
ASN A 138
ASP A 112
PHE A  92
PHE A  15
 None
 1.03A 2ejtA-3fs2A:
undetectable		 2ejtA-3fs2A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7q VALINE-PYRUVATE
AMINOTRANSFERASE

(Salmonella
enterica) 		PF00155
(Aminotran_1_2) 		5 LEU A 215
ILE A 261
ASN A 240
ILE A 213
ALA A 208
 None
 1.13A 2ejtA-3g7qA:
undetectable		 2ejtA-3g7qA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gi8 UNCHARACTERIZED
PROTEIN MJ0609

(Methanocaldococcus
jannaschii) 		PF13520
(AA_permease_2) 		5 LEU C  41
ILE C 191
ILE C 244
ALA C 240
PHE C  30
 None
 1.22A 2ejtA-3gi8C:
undetectable		 2ejtA-3gi8C:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gi8 UNCHARACTERIZED
PROTEIN MJ0609

(Methanocaldococcus
jannaschii) 		PF13520
(AA_permease_2) 		5 LEU C 103
ALA C 105
ILE C 125
ALA C  24
PHE C 334
 None
 1.21A 2ejtA-3gi8C:
undetectable		 2ejtA-3gi8C:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hi8 PROLIFERATING CELL
NUCLEAR ANTIGEN PCNA

(Haloferax
volcanii) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		5 LEU A  11
ALA A  82
ILE A 101
ALA A  77
ASP A  13
 None
 1.07A 2ejtA-3hi8A:
undetectable		 2ejtA-3hi8A:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hxw ALANYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF01411
(tRNA-synt_2c) 		5 LEU A 293
ALA A 291
ILE A 312
ASP A 296
PHE A  38
 None
 1.23A 2ejtA-3hxwA:
undetectable		 2ejtA-3hxwA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5p NUCLEOPORIN NUP170

(Saccharomyces
cerevisiae) 		PF03177
(Nucleoporin_C) 		5 ALA A1221
ILE A1301
ILE A1216
ALA A1214
PHE A1242
 None
 1.17A 2ejtA-3i5pA:
undetectable		 2ejtA-3i5pA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nd6 PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Enterococcus
faecalis) 		PF01467
(CTP_transf_like) 		5 LEU A  54
ALA A  58
ALA A 154
PHE A  11
PHE A  46
 None
 1.04A 2ejtA-3nd6A:
undetectable		 2ejtA-3nd6A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ne7 ACETYLTRANSFERASE

(Thermoplasma
acidophilum) 		PF00583
(Acetyltransf_1) 		5 LEU A  16
SER A  46
ALA A  20
ASP A  12
PHE A  77
 None
 1.19A 2ejtA-3ne7A:
undetectable		 2ejtA-3ne7A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pmq DECAHEME CYTOCHROME
C MTRF

(Shewanella
oneidensis) 		no annotation 5 LEU A 366
ARG A 367
ALA A 325
ASP A 365
PHE A 323
 None
 1.23A 2ejtA-3pmqA:
undetectable		 2ejtA-3pmqA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pmq DECAHEME CYTOCHROME
C MTRF

(Shewanella
oneidensis) 		no annotation 5 LEU A 366
ARG A 367
SER A 356
ALA A 325
ASP A 365
 None
 1.08A 2ejtA-3pmqA:
undetectable		 2ejtA-3pmqA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qh6 CT296

(Chlamydia
trachomatis) 		PF16802
(DUF5070) 		5 LEU A 113
ALA A 143
ILE A 102
SER A 116
ALA A  25
 None
 1.21A 2ejtA-3qh6A:
undetectable		 2ejtA-3qh6A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rza TRIPEPTIDASE

(Staphylococcus
aureus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 ASP A 167
ILE A 346
ILE A 148
SER A 145
ALA A 150
 ZN  A 401 (-2.2A)
None
None
None
None
 1.24A 2ejtA-3rzaA:
undetectable		 2ejtA-3rzaA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5n PUTATIVE
RHAMNOSIDASE

(Streptomyces
avermitilis) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		5 LEU A 542
ALA A 540
ARG A 543
ALA A 547
PHE A 914
 None
 1.23A 2ejtA-3w5nA:
undetectable		 2ejtA-3w5nA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wp8 TRIMERIC
AUTOTRANSPORTER
ADHESIN

(Acinetobacter
sp. Tol 5) 		PF05658
(YadA_head)
PF05662
(YadA_stalk) 		5 ALA A3029
ILE A3042
ASN A3023
ILE A3005
ALA A3007
 None
 1.14A 2ejtA-3wp8A:
undetectable		 2ejtA-3wp8A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zid TUBULIN/FTSZ, GTPASE

(Methanothrix
thermoacetophila) 		PF00091
(Tubulin) 		5 LEU A  17
ILE A 193
ASN A  14
ALA A  47
PHE A 107
 None
GDP  A 999 (-3.5A)
None
None
None
 1.15A 2ejtA-3zidA:
2.5		 2ejtA-3zidA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3u NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE

(Zymomonas
mobilis) 		PF00724
(Oxidored_FMN) 		5 LEU A 225
ILE A 231
ILE A 281
SER A 278
ALA A 246
 None
 1.13A 2ejtA-4a3uA:
undetectable		 2ejtA-4a3uA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1n IRON-SULFUR CLUSTER
BINDING PROTEIN

(Carboxydothermus
hydrogenoformans) 		PF14574
(DUF4445) 		5 LEU I 510
ILE I 468
ASN I 509
ALA I 402
PHE I 403
 None
None
B12  I1631 (-4.2A)
None
None
 1.21A 2ejtA-4c1nI:
undetectable		 2ejtA-4c1nI:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1o HISTIDINE
DECARBOXYLASE

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		5 LEU A 419
ALA A 471
ILE A 467
ASN A 422
SER A 476
 None
 1.22A 2ejtA-4e1oA:
2.9		 2ejtA-4e1oA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eff AROMATIC-AMINO-ACID
AMINOTRANSFERASE

(Burkholderia
pseudomallei) 		PF00155
(Aminotran_1_2) 		5 ASP A 190
LEU A 191
ALA A 229
ASN A 192
PHE A 161
 None
 1.22A 2ejtA-4effA:
undetectable		 2ejtA-4effA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E

(Linum
nodiflorum) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		5 ASP A 247
ASN A 245
ILE A 225
SER A 202
ALA A 219
 None
 1.19A 2ejtA-4eviA:
8.2		 2ejtA-4eviA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzv PUTATIVE
METHYLTRANSFERASE
NSUN4

(Homo sapiens) 		PF01189
(Methyltr_RsmB-F) 		5 ASP A 179
ALA A 183
ASN A 203
SER A 206
ASP A 255
 SAM  A 401 ( 4.2A)
SAM  A 401 (-4.1A)
SAM  A 401 ( 4.6A)
SAM  A 401 (-4.8A)
SAM  A 401 (-3.7A)
 0.90A 2ejtA-4fzvA:
11.6		 2ejtA-4fzvA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1u HEMIN TRANSPORT
SYSTEM PERMEASE
PROTEIN HMUU

(Yersinia pestis) 		PF01032
(FecCD) 		5 LEU A  69
ILE A 268
ILE A 247
ALA A 250
PHE A 259
 None
 1.07A 2ejtA-4g1uA:
undetectable		 2ejtA-4g1uA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzu PREDICTED MEMBRANE
PROTEIN
ENERGY-COUPLING
FACTOR TRANSPORTER
TRANSMEMBRANE
PROTEIN ECFT

(Lactobacillus
brevis;
Lactobacillus
brevis) 		PF07155
(ECF-ribofla_trS)
PF02361
(CbiQ) 		5 LEU T 165
ALA S  17
ARG T 166
SER S  63
ALA T 137
 None
 1.11A 2ejtA-4hzuT:
undetectable		 2ejtA-4hzuT:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jig DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF13561
(adh_short_C2) 		5 LEU A 247
ALA A 245
ARG A 191
ALA A 230
ASP A 248
 None
 1.24A 2ejtA-4jigA:
4.4		 2ejtA-4jigA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1

(Physcomitrella
patens) 		PF01156
(IU_nuc_hydro) 		5 LEU A 144
ALA A 148
ILE A 164
ALA A 140
ASP A 188
 None
 1.24A 2ejtA-4kpnA:
2.8		 2ejtA-4kpnA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpo NUCLEOSIDE
N-RIBOHYDROLASE 3

(Zea mays) 		PF01156
(IU_nuc_hydro) 		5 LEU A 126
ALA A 130
ILE A 146
ALA A 122
ASP A 170
 None
 1.20A 2ejtA-4kpoA:
2.8		 2ejtA-4kpoA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l60 PROLIFERATING CELL
NUCLEAR ANTIGEN

(Saccharomyces
cerevisiae) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		5 LEU A 236
ALA A 235
ILE A 160
ILE A 128
PHE A 248
 None
 1.19A 2ejtA-4l60A:
undetectable		 2ejtA-4l60A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lrs 4-HYDROXY-2-OXOVALER
ATE ALDOLASE

(Thermomonospora
curvata) 		PF00682
(HMGL-like)
PF07836
(DmpG_comm) 		5 LEU A  92
ALA A  90
ILE A  51
ILE A 116
ALA A 117
 None
None
None
None
PYR  A 402 ( 4.7A)
 1.22A 2ejtA-4lrsA:
undetectable		 2ejtA-4lrsA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE

(Eggerthella
lenta) 		PF00905
(Transpeptidase) 		5 LEU A 254
ALA A 251
SER A 280
ALA A 258
PHE A 184
 None
 1.20A 2ejtA-4mnrA:
undetectable		 2ejtA-4mnrA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nes UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Methanocaldococcus
jannaschii) 		PF02350
(Epimerase_2) 		5 LEU A 120
ILE A 131
ASN A 153
ALA A 150
ASP A  95
 None
None
None
None
UD1  A 400 ( 4.8A)
 1.16A 2ejtA-4nesA:
undetectable		 2ejtA-4nesA:
25.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oc9 PUTATIVE
O-ACETYLHOMOSERINE
(THIOL)-LYASE

(Campylobacter
jejuni) 		PF01053
(Cys_Met_Meta_PP) 		5 ASP A 241
LEU A 249
ALA A 236
ASN A 248
PHE A 257
 None
 1.16A 2ejtA-4oc9A:
undetectable		 2ejtA-4oc9A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rew 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		5 LEU A 214
ILE A 205
SER A 201
ALA A 208
ASP A 217
 None
 1.15A 2ejtA-4rewA:
undetectable		 2ejtA-4rewA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rpf HOMOSERINE KINASE

(Yersinia pestis) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 LEU A  20
ILE A 161
ILE A  10
SER A   9
PHE A  17
 None
 1.18A 2ejtA-4rpfA:
undetectable		 2ejtA-4rpfA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y2w ALANINE RACEMASE 1

(Caldanaerobacter
subterraneus) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 ALA A 170
ILE A 206
SER A 167
ALA A 211
ASP A 176
 None
 1.17A 2ejtA-4y2wA:
undetectable		 2ejtA-4y2wA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7e LMO1422 PROTEIN

(Listeria
monocytogenes) 		PF04069
(OpuAC) 		5 LEU A 414
ALA A 342
ARG A 403
ASN A 413
PHE A 392
 None
 1.22A 2ejtA-4z7eA:
undetectable		 2ejtA-4z7eA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
ALPHA

(Methanothermobacter
marburgensis) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		5 ALA A 290
ILE A 511
ILE A 310
SER A 306
ALA A 314
 None
 1.17A 2ejtA-5a8rA:
undetectable		 2ejtA-5a8rA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyx PROTEIN CDHR2

(Mus musculus) 		PF00028
(Cadherin) 		5 ASP A  18
LEU A  19
ARG A  97
SER A  63
ALA A  23
 None
 1.07A 2ejtA-5cyxA:
undetectable		 2ejtA-5cyxA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czr CADHERIN-RELATED
FAMILY MEMBER 2

(Homo sapiens) 		PF00028
(Cadherin) 		5 ASP A  18
LEU A  19
ARG A  97
SER A  63
ALA A  23
 None
 1.15A 2ejtA-5czrA:
undetectable		 2ejtA-5czrA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6b FUMARATE HYDRATASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		5 LEU A  99
ALA A  95
ILE A 201
ALA A 103
PHE A 191
 None
 1.21A 2ejtA-5d6bA:
undetectable		 2ejtA-5d6bA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f5p PROTEIN SHROOM2
RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens;
Homo sapiens) 		PF08687
(ASD2)
no annotation 		5 LEU A1501
ILE A1586
SER A1506
ALA C 848
PHE C 852
 None
None
None
None
CL  A1701 ( 4.5A)
 1.02A 2ejtA-5f5pA:
undetectable		 2ejtA-5f5pA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmq INFLUENZA A PB2
SUBUNIT

(Influenza A
virus) 		PF00604
(Flu_PB2) 		5 ASP A 671
LEU A 665
ALA A 674
ILE A 553
PHE A 656
 None
 0.99A 2ejtA-5fmqA:
undetectable		 2ejtA-5fmqA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5g PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT

(Escherichia
coli) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		5 LEU B 258
ALA B 245
ILE B 247
ALA B 303
PHE B 287
 None
None
IOD  B1317 ( 4.9A)
None
None
 1.23A 2ejtA-5g5gB:
undetectable		 2ejtA-5g5gB:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc8 ARACHIDONATE
15-LIPOXYGENASE

(Pseudomonas
aeruginosa) 		PF00305
(Lipoxygenase) 		5 ASP A 251
LEU A 283
ALA A 277
PHE A 317
PHE A 264
 None
 1.19A 2ejtA-5lc8A:
undetectable		 2ejtA-5lc8A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqm GLYCOSYL HYDROLASES
FAMILY 2, SUGAR
BINDING DOMAIN

(Bacteroides
thetaiotaomicron) 		PF17132
(Glyco_hydro_106) 		5 LEU A 839
ARG A 875
ILE A 845
ALA A 872
ASP A 838
 None
 1.23A 2ejtA-5mqmA:
undetectable		 2ejtA-5mqmA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwr TETR FAMILY
TRANSCRIPTIONAL
REGULATOR

(Sulfolobus
acidocaldarius) 		no annotation 5 ILE A  87
ILE A 159
SER A 155
ALA A 162
PHE A  97
 None
None
PTR  A 133 ( 3.4A)
None
None
 1.25A 2ejtA-5mwrA:
undetectable		 2ejtA-5mwrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ogz -

(-) 		no annotation 5 LEU A 401
ALA A  15
ILE A 353
SER A 354
PHE A 418
 None
 1.16A 2ejtA-5ogzA:
undetectable		 2ejtA-5ogzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u70 POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1

(Gallus gallus) 		PF03493
(BK_channel_a)
PF07885
(Ion_trans_2) 		5 LEU A 260
ILE A 252
ALA A 317
PHE A 262
PHE A 291
 None
 1.10A 2ejtA-5u70A:
4.5		 2ejtA-5u70A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		5 LEU B 253
ALA B 254
ALA B 314
ASP B 249
PHE B 316
 None
 1.23A 2ejtA-5w3jB:
2.2		 2ejtA-5w3jB:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7k OXAG

(Penicillium
oxalicum) 		no annotation 5 ASP A  52
ILE A  83
SER A  84
ALA A 110
PHE A 132
 None
SAH  A 301 (-3.9A)
None
SAH  A 301 (-3.4A)
SAH  A 301 (-4.6A)
 1.15A 2ejtA-5w7kA:
12.5		 2ejtA-5w7kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7m GLANDICOLINE B
O-METHYLTRANSFERASE
ROQN

(Penicillium
rubens) 		no annotation 5 ASP A  52
ILE A  83
SER A  84
ALA A 110
PHE A 132
 None
SAH  A 301 (-3.5A)
None
SAH  A 301 (-3.5A)
SAH  A 301 (-4.5A)
 1.21A 2ejtA-5w7mA:
12.6		 2ejtA-5w7mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wgg RADICAL SAM DOMAIN
PROTEIN
CTEA

(Ruminiclostridium
thermocellum;
Ruminiclostridium
thermocellum) 		PF04055
(Radical_SAM)
PF13186
(SPASM)
PF13353
(Fer4_12)
PF13165
(SCIFF) 		5 ALA A 447
ILE A 445
ASN B   8
ILE B   6
ALA A  22
 None
 1.21A 2ejtA-5wggA:
undetectable		 2ejtA-5wggA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194) 		5 LEU C3254
ALA C3246
ILE C3243
ALA C3006
PHE C3252
 None
 0.95A 2ejtA-5y3rC:
undetectable		 2ejtA-5y3rC:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byw GOXA

(Pseudoalteromonas
luteoviolacea) 		no annotation 5 LEU B 194
ILE B 597
ASN B 645
ALA B 642
ASP B 195
 None
 1.24A 2ejtA-6bywB:
undetectable		 2ejtA-6bywB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 5 ALA A 355
ARG A 426
ILE A 375
SER A 372
ASP A 401
 None
 1.17A 2ejtA-6cz4A:
undetectable		 2ejtA-6cz4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhs RUVB-LIKE HELICASE
INO80

(Chaetomium
thermophilum;
Chaetomium
thermophilum) 		no annotation
no annotation 		5 ASP A 245
LEU A 244
ARG A 118
SER G1309
ALA G1469
 None
 1.07A 2ejtA-6fhsA:
undetectable		 2ejtA-6fhsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1am2 MXE GYRA INTEIN

(Mycobacterium
xenopi) 		no annotation 3 ARG A 160
ASP A 154
ASP A 148
 None
 0.81A 2ejtA-1am2A:
undetectable		 2ejtA-1am2A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1avm SUPEROXIDE DISMUTASE

(Propionibacterium
freudenreichii) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		3 ARG A 199
ASP A 101
ASP A 108
 None
 0.87A 2ejtA-1avmA:
undetectable		 2ejtA-1avmA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bbu PROTEIN (LYSYL-TRNA
SYNTHETASE)

(Escherichia
coli) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		3 ARG A 262
ASP A 450
ASP A 447
 LYS  A 505 (-4.0A)
None
None
 0.86A 2ejtA-1bbuA:
undetectable		 2ejtA-1bbuA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cb8 PROTEIN
(CHONDROITINASE AC)

(Pedobacter
heparinus) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		3 ARG A 381
ASP A 452
ASP A 434
 None
 0.78A 2ejtA-1cb8A:
undetectable		 2ejtA-1cb8A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN 2

(Saccharomyces
cerevisiae) 		PF00675
(Peptidase_M16) 		3 ARG B  53
ASP B  83
ASP B 277
 None
 0.80A 2ejtA-1ezvB:
undetectable		 2ejtA-1ezvB:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1izo CYTOCHROME P450
152A1

(Bacillus
subtilis) 		PF00067
(p450) 		3 ARG A 144
ASP A 164
ASP A 171
 None
 0.75A 2ejtA-1izoA:
undetectable		 2ejtA-1izoA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p49 STERYL-SULFATASE

(Homo sapiens) 		PF00884
(Sulfatase)
PF14707
(Sulfatase_C) 		3 ARG A  51
ASP A  41
ASP A  36
 None
NAG  A 603 (-4.1A)
CA  A 605 (-2.5A)
 0.90A 2ejtA-1p49A:
undetectable		 2ejtA-1p49A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ph5 TELOMERE-BINDING
PROTEIN ALPHA
SUBUNIT

(Sterkiella nova) 		PF02765
(POT1) 		3 ARG A 274
ASP A 209
ASP A  93
 None
 0.71A 2ejtA-1ph5A:
undetectable		 2ejtA-1ph5A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pl0 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Homo sapiens) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		3 ARG A 335
ASP A 326
ASP A 323
 None
 0.86A 2ejtA-1pl0A:
2.7		 2ejtA-1pl0A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rxw FLAP
STRUCTURE-SPECIFIC
ENDONUCLEASE

(Archaeoglobus
fulgidus) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		3 ARG A 289
ASP A 147
ASP A  80
 None
 0.81A 2ejtA-1rxwA:
undetectable		 2ejtA-1rxwA:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfj CONSERVED
HYPOTHETICAL PROTEIN

(Caulobacter
vibrioides) 		PF02578
(Cu-oxidase_4) 		3 ARG A 252
ASP A  96
ASP A 139
 None
 0.72A 2ejtA-1xfjA:
undetectable		 2ejtA-1xfjA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xu0 PRION PROTEIN

(Xenopus laevis) 		PF00377
(Prion) 		3 ARG A 167
ASP A 180
ASP A 175
 None
 0.82A 2ejtA-1xu0A:
undetectable		 2ejtA-1xu0A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ycn PUTATIVE
CA2+-DEPENDENT
MEMBRANE-BINDING
PROTEIN ANNEXIN

(Arabidopsis
thaliana) 		PF00191
(Annexin) 		3 ARG A 196
ASP A 186
ASP A 181
 None
 0.62A 2ejtA-1ycnA:
undetectable		 2ejtA-1ycnA:
25.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bbk METHYLAMINE
DEHYDROGENASE (HEAVY
SUBUNIT)

(Paracoccus
denitrificans) 		PF06433
(Me-amine-dh_H) 		3 ARG H  33
ASP H  75
ASP H 134
 None
 0.74A 2ejtA-2bbkH:
undetectable		 2ejtA-2bbkH:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cas CANINE PARVOVIRUS
EMPTY CAPSID (STRAIN
D) VIRAL PROTEIN 2

(Carnivore
protoparvovirus
1) 		PF00740
(Parvo_coat) 		3 ARG A 209
ASP A 100
ASP A  88
 None
 0.78A 2ejtA-2casA:
undetectable		 2ejtA-2casA:
21.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dul N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE

(Pyrococcus
horikoshii) 		PF02005
(TRM) 		3 ARG A  36
ASP A  78
ASP A 120
 None
 0.23A 2ejtA-2dulA:
62.9		 2ejtA-2dulA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eax PEPTIDOGLYCAN
RECOGNITION
PROTEIN-I-BETA

(Homo sapiens) 		PF01510
(Amidase_2) 		3 ARG A 253
ASP A 258
ASP A 265
 None
 0.89A 2ejtA-2eaxA:
undetectable		 2ejtA-2eaxA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2exr CYTOKININ
DEHYDROGENASE 7

(Arabidopsis
thaliana) 		PF01565
(FAD_binding_4)
PF09265
(Cytokin-bind) 		3 ARG A 349
ASP A 258
ASP A 253
 None
 0.79A 2ejtA-2exrA:
undetectable		 2ejtA-2exrA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h09 TRANSCRIPTIONAL
REGULATOR MNTR

(Escherichia
coli) 		PF01325
(Fe_dep_repress)
PF02742
(Fe_dep_repr_C) 		3 ARG A  35
ASP A  40
ASP A  47
 None
 0.89A 2ejtA-2h09A:
undetectable		 2ejtA-2h09A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ice COMPLEMENT C3 BETA
CHAIN

(Homo sapiens) 		PF01835
(A2M_N)
PF07703
(A2M_N_2) 		3 ARG A 456
ASP A 527
ASP A 619
 None
 0.85A 2ejtA-2iceA:
undetectable		 2ejtA-2iceA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k2c RING FINGER AND CHY
ZINC FINGER
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF05495
(zf-CHY) 		3 ARG A  54
ASP A  45
ASP A  49
 None
 0.89A 2ejtA-2k2cA:
undetectable		 2ejtA-2k2cA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l8k NON-STRUCTURAL
PROTEIN 7

(Equine
arteritis virus) 		PF16749
(Arteri_nsp7a) 		3 ARG A  60
ASP A  19
ASP A  81
 None
 0.54A 2ejtA-2l8kA:
undetectable		 2ejtA-2l8kA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mou STAR-RELATED LIPID
TRANSFER PROTEIN 6

(Homo sapiens) 		PF01852
(START) 		3 ARG A 109
ASP A  75
ASP A  70
 None
 0.84A 2ejtA-2mouA:
undetectable		 2ejtA-2mouA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzt HEXOKINASE-2

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		3 ARG A  69
ASP A 164
ASP A 202
 None
 0.74A 2ejtA-2nztA:
undetectable		 2ejtA-2nztA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2k METHIONINE SYNTHASE

(Homo sapiens) 		PF02965
(Met_synt_B12) 		3 ARG A1027
ASP A 965
ASP A 971
 None
 0.82A 2ejtA-2o2kA:
undetectable		 2ejtA-2o2kA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o61 TRANSCRIPTION FACTOR
P65/INTERFERON
REGULATORY FACTOR
7/INTERFERON
REGULATORY FACTOR 3
FUSION PROTEIN

(Homo sapiens) 		PF00554
(RHD_DNA_bind)
PF00605
(IRF)
PF16179
(RHD_dimer) 		3 ARG A2081
ASP A2072
ASP A2069
 None
 0.78A 2ejtA-2o61A:
undetectable		 2ejtA-2o61A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ob1 LEUCINE CARBOXYL
METHYLTRANSFERASE 1

(Saccharomyces
cerevisiae) 		PF04072
(LCM) 		3 ARG A 111
ASP A 128
ASP A 175
 PO4  A2001 (-3.4A)
None
None
 0.73A 2ejtA-2ob1A:
9.1		 2ejtA-2ob1A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsj P-COUMARIC ACID
DECARBOXYLASE

(Lactobacillus
plantarum) 		PF05870
(PA_decarbox) 		3 ARG A  48
ASP A  37
ASP A 149
 IPA  A1180 ( 3.8A)
NA  A1181 ( 3.7A)
None
 0.80A 2ejtA-2wsjA:
undetectable		 2ejtA-2wsjA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xu0 ERYTHROCYTE MEMBRANE
PROTEIN 1

(Plasmodium
falciparum) 		PF05424
(Duffy_binding)
PF15447
(NTS) 		3 ARG A 480
ASP A 340
ASP A 369
 None
 0.89A 2ejtA-2xu0A:
undetectable		 2ejtA-2xu0A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yyb HYPOTHETICAL PROTEIN
TTHA1606

(Thermus
thermophilus) 		PF01784
(NIF3) 		3 ARG A 144
ASP A 183
ASP A 181
 None
 0.80A 2ejtA-2yybA:
undetectable		 2ejtA-2yybA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0u WW DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00168
(C2) 		3 ARG A  79
ASP A  82
ASP A  56
 None
 0.81A 2ejtA-2z0uA:
undetectable		 2ejtA-2z0uA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ziu MUS81 PROTEIN

(Danio rerio) 		PF02732
(ERCC4) 		3 ARG A 414
ASP A 326
ASP A 353
 None
 0.80A 2ejtA-2ziuA:
undetectable		 2ejtA-2ziuA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ay0 UNCHARACTERIZED
PROTEIN MJ0883

(Methanocaldococcus
jannaschii) 		PF02475
(Met_10) 		3 ARG A 186
ASP A 223
ASP A 251
 None
ADN  A 401 (-2.6A)
ADN  A 401 (-3.8A)
 0.63A 2ejtA-3ay0A:
17.6		 2ejtA-3ay0A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdk D-MANNONATE
DEHYDRATASE

(Streptococcus
suis) 		PF03786
(UxuA) 		3 ARG A 242
ASP A 221
ASP A 130
 None
None
DNO  A 387 (-3.4A)
 0.73A 2ejtA-3bdkA:
0.8		 2ejtA-3bdkA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cma 50S RIBOSOMAL
PROTEIN L32E

(Haloarcula
marismortui) 		PF01655
(Ribosomal_L32e) 		3 ARG Y 175
ASP Y 113
ASP Y 108
 G  01269 ( 3.4A)
None
None
 0.82A 2ejtA-3cmaY:
undetectable		 2ejtA-3cmaY:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ggd SAM-DEPENDENT
METHYLTRANSFERASE

(Trichormus
variabilis) 		PF13649
(Methyltransf_25) 		3 ARG A 130
ASP A  84
ASP A 108
 SAH  A 248 ( 3.9A)
SAH  A 248 (-2.9A)
SAH  A 248 (-3.7A)
 0.52A 2ejtA-3ggdA:
9.6		 2ejtA-3ggdA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h68 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5

(Homo sapiens) 		PF00149
(Metallophos)
PF08321
(PPP5) 		3 ARG A 373
ASP A 383
ASP A 388
 None
 0.66A 2ejtA-3h68A:
undetectable		 2ejtA-3h68A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h6z POLYCOMB PROTEIN
SFMBT

(Drosophila
melanogaster) 		PF02820
(MBT) 		3 ARG A 922
ASP A 725
ASP A 723
 None
 0.87A 2ejtA-3h6zA:
undetectable		 2ejtA-3h6zA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6x SOLUTE-BINDING
PROTEIN MA_0280

(Methanosarcina
acetivorans) 		PF13531
(SBP_bac_11) 		3 ARG A 148
ASP A 186
ASP A 181
 None
 0.81A 2ejtA-3k6xA:
undetectable		 2ejtA-3k6xA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1g PUTATIVE GLUTATHIONE
S-TRANSFERASE

(Corynebacterium
glutamicum) 		PF13409
(GST_N_2)
PF13410
(GST_C_2) 		3 ARG A 264
ASP A 253
ASP A 317
 None
 0.84A 2ejtA-3m1gA:
undetectable		 2ejtA-3m1gA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nhe UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 2

(Homo sapiens) 		PF00443
(UCH) 		3 ARG A 493
ASP A 408
ASP A 303
 None
 0.78A 2ejtA-3nheA:
undetectable		 2ejtA-3nheA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3niz RHODANESE FAMILY
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		3 ARG A 143
ASP A 162
ASP A 104
 None
MG  A 312 ( 3.3A)
ADP  A 314 (-4.1A)
 0.81A 2ejtA-3nizA:
undetectable		 2ejtA-3nizA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8s ADP-RIBOSE
PYROPHOSPHATASE

(Streptococcus
suis) 		PF00293
(NUDIX) 		3 ARG A 125
ASP A  80
ASP A 173
 ACT  A 211 (-3.4A)
None
None
 0.85A 2ejtA-3o8sA:
undetectable		 2ejtA-3o8sA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ow2 50S RIBOSOMAL
PROTEIN L32E

(Haloarcula
marismortui) 		PF01655
(Ribosomal_L32e) 		3 ARG X 175
ASP X 113
ASP X 108
 G  01269 ( 3.6A)
None
None
 0.78A 2ejtA-3ow2X:
undetectable		 2ejtA-3ow2X:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r31 BETAINE ALDEHYDE
DEHYDROGENASE

(Agrobacterium
fabrum) 		PF00171
(Aldedh) 		3 ARG A  88
ASP A 113
ASP A 101
 None
 0.90A 2ejtA-3r31A:
4.8		 2ejtA-3r31A:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8v RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L

(Escherichia
coli) 		PF01170
(UPF0020)
PF02926
(THUMP)
PF10672
(Methyltrans_SAM) 		3 ARG A 530
ASP A 568
ASP A 597
 None
SAM  A 802 (-2.9A)
SAM  A 802 (-3.5A)
 0.62A 2ejtA-3v8vA:
14.2		 2ejtA-3v8vA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vse PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF10672
(Methyltrans_SAM) 		3 ARG A 205
ASP A 243
ASP A 272
 None
SAH  A 401 (-2.7A)
SAH  A 401 (-3.0A)
 0.72A 2ejtA-3vseA:
14.3		 2ejtA-3vseA:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vwa CYTOPLASMIC EXPORT
PROTEIN 1

(Saccharomyces
cerevisiae) 		no annotation 3 ARG A 230
ASP A 191
ASP A 186
 None
 0.80A 2ejtA-3vwaA:
undetectable		 2ejtA-3vwaA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wy2 ALPHA-GLUCOSIDASE

(Halomonas sp.
H11) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		3 ARG A 181
ASP A 186
ASP A 193
 GOL  A 602 (-4.3A)
None
None
 0.82A 2ejtA-3wy2A:
undetectable		 2ejtA-3wy2A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zkb DNA GYRASE SUBUNIT B

(Mycobacterium
tuberculosis) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		3 ARG A 172
ASP A  79
ASP A  55
 None
ANP  A 601 (-3.7A)
None
 0.89A 2ejtA-3zkbA:
undetectable		 2ejtA-3zkbA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akr F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA

(Dictyostelium
discoideum) 		PF01115
(F_actin_cap_B) 		3 ARG B  14
ASP B  44
ASP B  63
 None
 0.81A 2ejtA-4akrB:
undetectable		 2ejtA-4akrB:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4awn DEOXYRIBONUCLEASE-1

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		3 ARG A 117
ASP A 153
ASP A  99
 None
None
CA  A 300 (-2.5A)
 0.55A 2ejtA-4awnA:
undetectable		 2ejtA-4awnA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 2
GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 5

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF04153
(NOT2_3_5)
PF04153
(NOT2_3_5) 		3 ARG C 533
ASP C 473
ASP B 109
 None
 0.73A 2ejtA-4by6C:
undetectable		 2ejtA-4by6C:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqy ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE

(Burkholderia
thailandensis) 		PF00132
(Hexapep)
PF13720
(Acetyltransf_11) 		3 ARG A 161
ASP A 146
ASP A 110
 None
 0.84A 2ejtA-4eqyA:
undetectable		 2ejtA-4eqyA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ex5 LYSINE--TRNA LIGASE

(Burkholderia
thailandensis) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		3 ARG A 262
ASP A 454
ASP A 451
 LYS  A 601 (-3.7A)
None
None
 0.84A 2ejtA-4ex5A:
undetectable		 2ejtA-4ex5A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f1k THROMBOSPONDIN
RELATED ANONYMOUS
PROTEIN

(Plasmodium
falciparum) 		PF00092
(VWA) 		3 ARG A 181
ASP A  48
ASP A  45
 SO4  A 303 (-4.2A)
None
None
 0.75A 2ejtA-4f1kA:
undetectable		 2ejtA-4f1kA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f8q BUTYROPHILIN
SUBFAMILY 3 MEMBER
A2

(Homo sapiens) 		PF07686
(V-set) 		3 ARG A  72
ASP A 101
ASP A 103
 None
 0.68A 2ejtA-4f8qA:
undetectable		 2ejtA-4f8qA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fe2 PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Streptococcus
pneumoniae) 		PF01259
(SAICAR_synt) 		3 ARG A 214
ASP A 128
ASP A 125
 AIR  A 301 (-3.1A)
ASP  A 306 ( 4.0A)
None
 0.79A 2ejtA-4fe2A:
undetectable		 2ejtA-4fe2A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gf8 PEPTIDE ABC
TRANSPORTER,
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Vibrio cholerae) 		PF00496
(SBP_bac_5) 		3 ARG A 120
ASP A  60
ASP A 458
 None
 0.82A 2ejtA-4gf8A:
undetectable		 2ejtA-4gf8A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4haq GH7 FAMILY PROTEIN

(Limnoria
quadripunctata) 		PF00840
(Glyco_hydro_7) 		3 ARG A 128
ASP A 394
ASP A 426
 None
 0.87A 2ejtA-4haqA:
undetectable		 2ejtA-4haqA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hoz SUCROSE ISOMERASE

(Erwinia
rhapontici) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		3 ARG A 328
ASP A 322
ASP A 302
 None
 0.87A 2ejtA-4hozA:
undetectable		 2ejtA-4hozA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jkw BUTYROPHILIN
SUBFAMILY 3 MEMBER
A1

(Homo sapiens) 		PF07686
(V-set) 		3 ARG A  74
ASP A 103
ASP A 105
 None
 0.67A 2ejtA-4jkwA:
undetectable		 2ejtA-4jkwA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ksf MALONYL-COA
DECARBOXYLASE

(Agrobacterium
vitis) 		PF05292
(MCD)
PF17408
(MCD_N) 		3 ARG A 397
ASP A 244
ASP A 251
 None
 0.54A 2ejtA-4ksfA:
undetectable		 2ejtA-4ksfA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kyi VIPD

(Legionella
pneumophila) 		PF01734
(Patatin) 		3 ARG A 112
ASP A 116
ASP A 123
 None
 0.77A 2ejtA-4kyiA:
undetectable		 2ejtA-4kyiA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00169
(PH)
PF00615
(RGS) 		3 ARG A 316
ASP A 335
ASP A 278
 None
29X  A 702 (-4.4A)
29X  A 702 ( 4.8A)
 0.79A 2ejtA-4mk0A:
undetectable		 2ejtA-4mk0A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n01 PERIPLASMIC BINDING
PROTEIN

(Veillonella
parvula) 		PF01497
(Peripla_BP_2) 		3 ARG A 305
ASP A 212
ASP A 215
 None
GOL  A 404 ( 4.5A)
None
 0.67A 2ejtA-4n01A:
3.1		 2ejtA-4n01A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxg TYPE-2 RESTRICTION
ENZYME SAU3AI

(Staphylococcus
aureus) 		PF02976
(MutH) 		3 ARG A 199
ASP A 150
ASP A 143
 None
 0.82A 2ejtA-4pxgA:
undetectable		 2ejtA-4pxgA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		3 ARG A2570
ASP A3020
ASP A3015
 None
 0.68A 2ejtA-4qyrA:
undetectable		 2ejtA-4qyrA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3a BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2

(Erythrobacter
litoralis) 		PF07568
(HisKA_2)
PF13426
(PAS_9)
PF13581
(HATPase_c_2) 		3 ARG A  15
ASP A 187
ASP A 134
 None
 0.76A 2ejtA-4r3aA:
undetectable		 2ejtA-4r3aA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rml LATROPHILIN-3

(Mus musculus) 		PF02191
(OLF) 		3 ARG A 246
ASP A 275
ASP A 332
 None
TRS  A 602 (-2.7A)
MG  A 601 ( 4.6A)
 0.72A 2ejtA-4rmlA:
undetectable		 2ejtA-4rmlA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ubd MONOCLONAL ANTIBODY
H CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 ARG C 104
ASP C  99
ASP C  59
 None
 0.85A 2ejtA-4ubdC:
undetectable		 2ejtA-4ubdC:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4us5 LUCIFERASE-LIKE
MONOOXYGENASE

(Streptomyces
bottropensis) 		PF00296
(Bac_luciferase) 		3 ARG A 323
ASP A 314
ASP A 258
 None
 0.84A 2ejtA-4us5A:
undetectable		 2ejtA-4us5A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		3 ARG A 313
ASP A 332
ASP A 271
 None
 0.87A 2ejtA-4wboA:
undetectable		 2ejtA-4wboA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xb3 GLUCAN
1,6-ALPHA-GLUCOSIDAS
E

(Streptococcus
mutans) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		3 ARG A 173
ASP A 178
ASP A 185
 None
 0.85A 2ejtA-4xb3A:
undetectable		 2ejtA-4xb3A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypl LON PROTEASE

(Meiothermus
taiwanensis) 		PF00004
(AAA)
PF05362
(Lon_C) 		3 ARG A 272
ASP A 457
ASP A 453
 None
 0.75A 2ejtA-4yplA:
undetectable		 2ejtA-4yplA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zsl MITOGEN-ACTIVATED
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		3 ARG A 181
ASP A 200
ASP A 143
 None
 0.80A 2ejtA-4zslA:
undetectable		 2ejtA-4zslA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a22 VESICULAR STOMATITIS
VIRUS L POLYMERASE

(Vesicular
stomatitis
virus) 		PF00946
(Mononeg_RNA_pol)
PF14314
(Methyltrans_Mon)
PF14318
(Mononeg_mRNAcap) 		3 ARG A 728
ASP A2023
ASP A2018
 None
 0.88A 2ejtA-5a22A:
8.0		 2ejtA-5a22A:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ayu IG VH,ANTI-LYSOZYME

(Mus musculus) 		PF07686
(V-set) 		3 ARG H  71
ASP H  27
ASP H 101
 None
 0.87A 2ejtA-5ayuH:
undetectable		 2ejtA-5ayuH:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5az4 FLAGELLAR HOOK
SUBUNIT PROTEIN

(Campylobacter
jejuni) 		PF07196
(Flagellin_IN)
PF07559
(FlaE) 		3 ARG A 684
ASP A 235
ASP A 505
 None
 0.67A 2ejtA-5az4A:
undetectable		 2ejtA-5az4A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyb DNA-BINDING PROTEIN
REB1

(Schizosaccharomyces
pombe) 		PF00249
(Myb_DNA-binding) 		3 ARG A 340
ASP A 348
ASP A 355
 None
 0.88A 2ejtA-5eybA:
undetectable		 2ejtA-5eybA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f5v PRP38
PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum;
Chaetomium
thermophilum) 		PF03371
(PRP38)
PF06991
(MFAP1) 		3 ARG A 117
ASP B 220
ASP B 222
 None
 0.81A 2ejtA-5f5vA:
undetectable		 2ejtA-5f5vA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7s GLYCOSIDE HYDROLASE
FAMILY 31

(Trueperella
pyogenes) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		3 ARG A 484
ASP A 253
ASP A 193
 None
 0.72A 2ejtA-5f7sA:
undetectable		 2ejtA-5f7sA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ggk PROTEIN
O-LINKED-MANNOSE
BETA-1,2-N-ACETYLGLU
COSAMINYLTRANSFERASE
1

(Homo sapiens) 		PF15711
(ILEI) 		3 ARG A 129
ASP A 157
ASP A 187
 EDO  A 305 ( 3.6A)
None
None
 0.63A 2ejtA-5ggkA:
undetectable		 2ejtA-5ggkA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7j ELONGATION FACTOR 2

(Pyrococcus
horikoshii) 		no annotation 3 ARG A 651
ASP A 103
ASP A 107
 None
 0.77A 2ejtA-5h7jA:
undetectable		 2ejtA-5h7jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idq SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Burkholderia
vietnamiensis) 		PF00106
(adh_short) 		3 ARG A  22
ASP A  72
ASP A 120
 None
 0.89A 2ejtA-5idqA:
5.1		 2ejtA-5idqA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jd5 MGS-MILE3

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		3 ARG A 185
ASP A 142
ASP A  77
 None
 0.87A 2ejtA-5jd5A:
undetectable		 2ejtA-5jd5A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzw AEROLYSIN

(Aeromonas
hydrophila) 		PF01117
(Aerolysin)
PF03440
(APT) 		3 ARG A 356
ASP A 311
ASP A 180
 None
 0.84A 2ejtA-5jzwA:
undetectable		 2ejtA-5jzwA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kov CAPSID POLYPROTEIN
VP90
PL-2 SCFV CHAIN

(Mamastrovirus
1;
Mus musculus) 		PF12226
(Astro_capsid_p)
PF07686
(V-set) 		3 ARG A 610
ASP A 465
ASP C  31
 None
 0.52A 2ejtA-5kovA:
undetectable		 2ejtA-5kovA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc2 PROTEIN FAM3C

(Homo sapiens) 		PF15711
(ILEI) 		3 ARG A 179
ASP A 123
ASP A 128
 None
 0.77A 2ejtA-5lc2A:
undetectable		 2ejtA-5lc2A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m22 HYDROQUINONE
DIOXYGENASE SMALL
SUBUNIT
HYDROQUINONE
DIOXYGENASE LARGE
SUBUNIT

(Sphingomonas
sp. TTNP3;
Sphingomonas
sp. TTNP3) 		no annotation
no annotation 		3 ARG B 109
ASP B 279
ASP A  23
 None
 0.72A 2ejtA-5m22B:
undetectable		 2ejtA-5m22B:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqs BETA-L-ARABINOBIOSID
ASE

(Bacteroides
thetaiotaomicron) 		PF13088
(BNR_2) 		3 ARG A 512
ASP A 491
ASP A 494
 None
 0.87A 2ejtA-5mqsA:
undetectable		 2ejtA-5mqsA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tr0 SEED LINOLEATE
13S-LIPOXYGENASE-1

(Glycine max) 		no annotation 3 ARG A 831
ASP A 613
ASP A 607
 None
 0.89A 2ejtA-5tr0A:
undetectable		 2ejtA-5tr0A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u3c CTP SYNTHASE

(Escherichia
coli) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		3 ARG A 211
ASP A  72
ASP A  42
 ADP  A 602 (-3.4A)
ADP  A 602 (-3.8A)
None
 0.83A 2ejtA-5u3cA:
undetectable		 2ejtA-5u3cA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		3 ARG A 213
ASP A 232
ASP A 176
 None
 0.83A 2ejtA-5u7qA:
undetectable		 2ejtA-5u7qA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uso PROTECTION OF
TELOMERES PROTEIN 1

(Schizosaccharomyces
pombe) 		no annotation 3 ARG A  59
ASP A  87
ASP A 124
 None
 0.57A 2ejtA-5usoA:
undetectable		 2ejtA-5usoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uyt ICE-BINDING PROTEIN

(Flavobacteriaceae
bacterium
3519-10) 		no annotation 3 ARG A 221
ASP A  53
ASP A  73
 None
 0.86A 2ejtA-5uytA:
undetectable		 2ejtA-5uytA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x3e KINESIN-LIKE PROTEIN

(Caenorhabditis
elegans) 		PF00225
(Kinesin) 		3 ARG A 242
ASP A 249
ASP A 223
 SO4  A 512 (-4.2A)
None
None
 0.68A 2ejtA-5x3eA:
undetectable		 2ejtA-5x3eA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yac TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5B

(Pyrococcus
abyssi) 		PF02475
(Met_10) 		3 ARG A 173
ASP A 211
ASP A 238
 None
 0.52A 2ejtA-5yacA:
18.5		 2ejtA-5yacA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6anr COLIBACTIN
SELF-PROTECTION
PROTEIN CLBS

(Escherichia
coli) 		no annotation 3 ARG A  90
ASP A  98
ASP A 101
 None
 0.80A 2ejtA-6anrA:
undetectable		 2ejtA-6anrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6h20 -

(-) 		no annotation 3 ARG A 325
ASP A 181
ASP A 250
 None
None
ASN  A 401 (-2.9A)
 0.85A 2ejtA-6h20A:
undetectable		 2ejtA-6h20A:
undetectable