SIMILAR PATTERNS OF AMINO ACIDS FOR 2EJG_B_ADNB1502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)

(Paracoccus
denitrificans) 		PF00766
(ETF_alpha)
PF01012
(ETF) 		4 ARG A 125
GLU B  97
PRO B  98
ALA B 130
 None
None
AMP  A 400 ( 4.6A)
AMP  A 400 (-4.4A)
 1.28A 2ejgB-1efpA:
undetectable		 2ejgB-1efpA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gp1 GLUTATHIONE
PEROXIDASE

(Bos taurus) 		PF00255
(GSHPx) 		4 ARG A 178
GLU A 161
PRO A 132
ALA A 136
 None
 1.47A 2ejgB-1gp1A:
0.4		 2ejgB-1gp1A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gxl CHROMOSOME
SEGREGATION SMC
PROTEIN

(Thermotoga
maritima) 		PF06470
(SMC_hinge) 		4 LYS A 554
ASN A 549
PRO A 572
ALA A 553
 None
 1.50A 2ejgB-1gxlA:
1.3		 2ejgB-1gxlA:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idm 3-ISOPROPYLMALATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00180
(Iso_dh) 		4 ARG A 102
GLU A 268
PRO A 269
ALA A 287
 None
 1.47A 2ejgB-1idmA:
undetectable		 2ejgB-1idmA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k8i MHC CLASS II H2-M
BETA 2 CHAIN

(Mus musculus) 		PF00969
(MHC_II_beta)
PF07654
(C1-set) 		4 GLU B  55
LYS B  41
ASN B  62
PRO B  44
 None
 1.39A 2ejgB-1k8iB:
undetectable		 2ejgB-1k8iB:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lt3 HEAT-LABILE
ENTEROTOXIN

(Escherichia
coli) 		PF01375
(Enterotoxin_a) 		4 ARG A 163
GLU A 159
PRO A 157
ALA A 156
 None
 1.47A 2ejgB-1lt3A:
undetectable		 2ejgB-1lt3A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ltt HEAT-LABILE
ENTEROTOXIN, SUBUNIT
A

(Escherichia
coli) 		PF01375
(Enterotoxin_a) 		4 ARG A 163
GLU A 159
PRO A 157
ALA A 156
 None
 1.45A 2ejgB-1lttA:
undetectable		 2ejgB-1lttA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n8y PROTOONCOPROTEIN

(Rattus
norvegicus) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		4 ARG C 117
GLU C 186
PRO C 172
ALA C 170
 None
 1.42A 2ejgB-1n8yC:
undetectable		 2ejgB-1n8yC:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nnh ASPARAGINYL-TRNA
SYNTHETASE-RELATED
PEPTIDE

(Pyrococcus
furiosus) 		PF00152
(tRNA-synt_2) 		4 TRP A 202
LYS A 232
PRO A  51
ALA A 236
 None
 1.32A 2ejgB-1nnhA:
4.0		 2ejgB-1nnhA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1npb FOSFOMYCIN-RESISTANC
E PROTEIN

(Serratia
marcescens) 		PF00903
(Glyoxalase) 		4 ARG A 122
GLU A  98
ASN A  95
ALA A 100
 SO4  A 403 ( 3.4A)
None
None
None
 1.28A 2ejgB-1npbA:
undetectable		 2ejgB-1npbA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ocs SORTING NEXIN GRD19

(Saccharomyces
cerevisiae) 		PF00787
(PX) 		4 GLU A  33
ASN A  67
PRO A  32
ALA A  30
 None
 1.46A 2ejgB-1ocsA:
undetectable		 2ejgB-1ocsA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qpp PAPD CHAPERONE

(Escherichia
coli) 		PF00345
(PapD_N)
PF02753
(PapD_C) 		4 ARG A 176
GLU A  83
PRO A 117
ALA A 119
 None
 1.43A 2ejgB-1qppA:
undetectable		 2ejgB-1qppA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ued P450 MONOOXYGENASE

(Amycolatopsis
orientalis) 		PF00067
(p450) 		4 ARG A 326
GLU A 284
ASN A 264
ALA A 260
 None
 1.09A 2ejgB-1uedA:
undetectable		 2ejgB-1uedA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vzh DESULFOFERRODOXIN

(Desulfarculus
baarsii) 		PF01880
(Desulfoferrodox)
PF06397
(Desulfoferrod_N) 		4 GLU A 114
ASN A  40
PRO A  51
ALA A 124
 None
 1.18A 2ejgB-1vzhA:
undetectable		 2ejgB-1vzhA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xpn HYPOTHETICAL PROTEIN
PA1324

(Pseudomonas
aeruginosa) 		no annotation 4 ARG A 104
GLU A  32
PRO A  28
ALA A  78
 None
 1.41A 2ejgB-1xpnA:
undetectable		 2ejgB-1xpnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8x UBIQUITIN-CONJUGATIN
G ENZYME E2 M

(Homo sapiens) 		PF00179
(UQ_con) 		4 GLU A 142
LYS A 147
PRO A 141
ALA A 150
 None
 1.18A 2ejgB-1y8xA:
undetectable		 2ejgB-1y8xA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ycd HYPOTHETICAL 27.3
KDA PROTEIN IN
AAP1-SMF2 INTERGENIC
REGION

(Saccharomyces
cerevisiae) 		PF03959
(FSH1) 		4 LYS A 200
ASN A 203
PRO A 169
ALA A 201
 None
 1.19A 2ejgB-1ycdA:
undetectable		 2ejgB-1ycdA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3z DIALKYLGLYCINE
DECARBOXYLASE

(Burkholderia
cepacia) 		PF00202
(Aminotran_3) 		4 ARG A 176
GLU A 188
PRO A 168
ALA A 135
 None
 1.48A 2ejgB-1z3zA:
1.3		 2ejgB-1z3zA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cya TYROSYL-TRNA
SYNTHETASE

(Aeropyrum
pernix) 		PF00579
(tRNA-synt_1b) 		4 ARG A  92
GLU A  73
PRO A  44
ALA A  78
 None
 1.26A 2ejgB-2cyaA:
undetectable		 2ejgB-2cyaA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4e 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
SEMIALDEHYDE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00171
(Aldedh) 		4 GLU A 486
ASN A 131
PRO A 185
ALA A 184
 None
 1.42A 2ejgB-2d4eA:
undetectable		 2ejgB-2d4eA:
19.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2djz 235AA LONG
HYPOTHETICAL
BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE

(Pyrococcus
horikoshii) 		PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB) 		5 TRP A  53
GLU A  54
ASN A 131
PRO A 137
ALA A 140
 BT5  A1301 (-3.8A)
None
BT5  A1301 (-3.0A)
BT5  A1301 (-4.6A)
BT5  A1301 (-3.4A)
 0.28A 2ejgB-2djzA:
39.2		 2ejgB-2djzA:
99.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dqa LYSOZYME

(Ruditapes
philippinarum) 		PF05497
(Destabilase) 		4 LYS A  68
ASN A  64
PRO A   3
ALA A   2
 None
 1.35A 2ejgB-2dqaA:
undetectable		 2ejgB-2dqaA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ecf DIPEPTIDYL PEPTIDASE
IV

(Stenotrophomonas
maltophilia) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 TRP A 639
ASN A 611
PRO A 527
ALA A 528
 None
 1.03A 2ejgB-2ecfA:
undetectable		 2ejgB-2ecfA:
15.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ej9 PUTATIVE BIOTIN
LIGASE

(Methanocaldococcus
jannaschii) 		PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB) 		4 TRP A  45
LYS A 106
ASN A 126
ALA A 139
 BTN  A1301 (-3.9A)
BTN  A1301 (-2.6A)
None
None
 0.48A 2ejgB-2ej9A:
26.1		 2ejgB-2ej9A:
37.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2exn HYPOTHETICAL PROTEIN
BOR11

(Bordetella
bronchiseptica) 		PF03476
(MOSC_N) 		4 ARG A  44
GLU A  47
PRO A  62
ALA A  61
 None
 1.43A 2ejgB-2exnA:
undetectable		 2ejgB-2exnA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gw1 MITOCHONDRIAL
PRECURSOR PROTEINS
IMPORT RECEPTOR

(Saccharomyces
cerevisiae) 		PF00515
(TPR_1)
PF13181
(TPR_8)
PF13432
(TPR_16) 		4 ARG A 293
GLU A 495
PRO A 465
ALA A 464
 None
 1.40A 2ejgB-2gw1A:
undetectable		 2ejgB-2gw1A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hyx PROTEIN DIPZ

(Mycobacterium
tuberculosis) 		PF00578
(AhpC-TSA) 		4 GLU A 527
LYS A 524
PRO A 509
ALA A 510
 None
 1.25A 2ejgB-2hyxA:
undetectable		 2ejgB-2hyxA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l7j POLIOVIRUS
RECEPTOR-RELATED 1

(Mus musculus) 		PF13895
(Ig_2) 		4 ARG A 298
ASN A 320
PRO A 276
ALA A 273
 None
 1.34A 2ejgB-2l7jA:
undetectable		 2ejgB-2l7jA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvf EXOPOLYGALACTURONASE

(Yersinia
enterocolitica) 		PF00295
(Glyco_hydro_28)
PF12708
(Pectate_lyase_3) 		4 GLU A  61
LYS A  58
ASN A 455
ALA A  59
 None
 1.43A 2ejgB-2uvfA:
undetectable		 2ejgB-2uvfA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpw THIOSULFATE
REDUCTASE

(Thermus
thermophilus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 GLU A 663
LYS A 657
PRO A 684
ALA A 656
 None
 1.46A 2ejgB-2vpwA:
undetectable		 2ejgB-2vpwA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yk0 ERYTHROCYTE MEMBRANE
PROTEIN 1

(Plasmodium
falciparum) 		PF03011
(PFEMP)
PF05424
(Duffy_binding)
PF15447
(NTS) 		4 ARG A 314
GLU A 318
PRO A 132
ALA A 131
 None
 1.37A 2ejgB-2yk0A:
undetectable		 2ejgB-2yk0A:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yvt HYPOTHETICAL PROTEIN
AQ_1956

(Aquifex
aeolicus) 		PF14582
(Metallophos_3) 		4 GLU A  71
ASN A  45
PRO A 102
ALA A 101
 None
 1.25A 2ejgB-2yvtA:
undetectable		 2ejgB-2yvtA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z00 DIHYDROOROTASE

(Thermus
thermophilus) 		PF01979
(Amidohydro_1) 		4 GLU A 205
ASN A 200
PRO A 280
ALA A 279
 None
 1.42A 2ejgB-2z00A:
undetectable		 2ejgB-2z00A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bf8 ESTERASE YBFF

(Escherichia
coli) 		PF12697
(Abhydrolase_6) 		4 TRP A 188
GLU A 189
PRO A  65
ALA A  68
 None
 1.22A 2ejgB-3bf8A:
undetectable		 2ejgB-3bf8A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cnj CHOLESTEROL OXIDASE

(Streptomyces
sp. SA-COO) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 ARG A 385
ASN A 406
PRO A 408
ALA A 409
 None
 1.29A 2ejgB-3cnjA:
undetectable		 2ejgB-3cnjA:
21.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3efs BIOTIN
[ACETYL-COA-CARBOXYL
ASE] LIGASE

(Aquifex
aeolicus) 		PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB) 		4 TRP A  45
LYS A 103
ASN A 123
ALA A 137
 BTN  A2001 ( 3.7A)
ATP  A1001 ( 3.1A)
ATP  A1001 (-2.8A)
ATP  A1001 (-3.4A)
 0.52A 2ejgB-3efsA:
28.1		 2ejgB-3efsA:
35.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT

(Eubacterium
barkeri) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 GLU A 128
ASN A 149
PRO A 142
ALA A 143
 None
 1.29A 2ejgB-3hrdA:
undetectable		 2ejgB-3hrdA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iuz PUTATIVE GLYOXALASE
SUPERFAMILY PROTEIN

(Cupriavidus
pinatubonensis) 		PF07063
(DUF1338) 		4 ARG A 307
GLU A 136
PRO A 135
ALA A 130
 None
 1.47A 2ejgB-3iuzA:
undetectable		 2ejgB-3iuzA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nv9 MALIC ENZYME

(Entamoeba
histolytica) 		PF00390
(malic)
PF03949
(Malic_M) 		4 GLU A 446
LYS A 368
PRO A 415
ALA A 418
 None
 1.25A 2ejgB-3nv9A:
undetectable		 2ejgB-3nv9A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwp 6-PHOSPHOGLUCONOLACT
ONASE

(Shewanella
baltica) 		PF01182
(Glucosamine_iso) 		4 TRP A  74
GLU A  72
ASN A 106
ALA A 118
 None
 1.22A 2ejgB-3nwpA:
undetectable		 2ejgB-3nwpA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o2u NEDD8-CONJUGATING
ENZYME UBC12

(Saccharomyces
cerevisiae) 		PF00179
(UQ_con) 		4 LYS A1155
ASN A1150
PRO A1148
ALA A1154
 None
 1.40A 2ejgB-3o2uA:
undetectable		 2ejgB-3o2uA:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8t ASNS-LIKE
ASPARAGINYL-TRNA
SYNTHETASE RELATED
PROTEIN

(Pyrococcus
abyssi) 		PF00152
(tRNA-synt_2) 		4 TRP A 202
LYS A 232
PRO A  51
ALA A 236
 None
 1.35A 2ejgB-3p8tA:
4.6		 2ejgB-3p8tA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qka ENOYL-COA HYDRATASE,
ECHA5

(Mycobacterium
marinum) 		PF00378
(ECH_1) 		4 GLU A  73
ASN A  75
PRO A  30
ALA A  32
 None
 1.16A 2ejgB-3qkaA:
undetectable		 2ejgB-3qkaA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rjo ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1

(Homo sapiens) 		PF11838
(ERAP1_C) 		4 GLU A 669
ASN A 634
PRO A 672
ALA A 637
 None
 1.49A 2ejgB-3rjoA:
undetectable		 2ejgB-3rjoA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u80 3-DEHYDROQUINATE
DEHYDRATASE, TYPE II

(Bifidobacterium
longum) 		PF01220
(DHquinase_II) 		4 GLU A 101
ASN A   8
PRO A  75
ALA A  76
 None
 1.45A 2ejgB-3u80A:
undetectable		 2ejgB-3u80A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u95 GLYCOSIDE HYDROLASE,
FAMILY 4

(Thermotoga
neapolitana) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		4 GLU A 394
ASN A 215
PRO A 383
ALA A 206
 None
 1.31A 2ejgB-3u95A:
undetectable		 2ejgB-3u95A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v65 AGRIN
LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 4

(Rattus
norvegicus) 		PF00054
(Laminin_G_1)
PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition) 		4 GLU A1780
LYS B 618
ASN A1783
ALA B 617
 None
 1.45A 2ejgB-3v65A:
undetectable		 2ejgB-3v65A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v78 PROBABLE
TRANSCRIPTIONAL
REGULATORY PROTEIN
(PROBABLY
DEOR-FAMILY)

(Mycobacterium
tuberculosis) 		PF00440
(TetR_N) 		4 ARG A  16
GLU A  21
ASN A  71
ALA A  67
 None
 1.46A 2ejgB-3v78A:
undetectable		 2ejgB-3v78A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsz RICIN B LECTIN

(Ruminiclostridium
thermocellum) 		PF04616
(Glyco_hydro_43)
PF14200
(RicinB_lectin_2) 		4 ARG A 113
GLU A 229
ASN A 253
ALA A 255
 None
 1.32A 2ejgB-3vszA:
undetectable		 2ejgB-3vszA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wo0 ALANINE-ANTICAPSIN
LIGASE BACD

(Bacillus
subtilis) 		PF13535
(ATP-grasp_4) 		4 GLU A 319
LYS A 296
PRO A 320
ALA A 293
 None
 1.41A 2ejgB-3wo0A:
1.6		 2ejgB-3wo0A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b6z FAMILY M14
UNASSIGNED PEPTIDASE

(Burkholderia
cenocepacia) 		PF00246
(Peptidase_M14) 		4 ARG A  52
GLU A  51
PRO A  22
ALA A  24
 None
 1.39A 2ejgB-4b6zA:
undetectable		 2ejgB-4b6zA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 ARG A 813
GLU A 897
PRO A 896
ALA A 837
 None
 1.50A 2ejgB-4crsA:
undetectable		 2ejgB-4crsA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h6a ALLENE OXIDE CYCLASE

(Physcomitrella
patens) 		PF06351
(Allene_ox_cyc) 		4 GLU A 169
LYS A 176
PRO A 170
ALA A 174
 None
 1.27A 2ejgB-4h6aA:
undetectable		 2ejgB-4h6aA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iy9 30K PROTEIN 1

(Bombyx mori) 		PF03260
(Lipoprotein_11) 		4 LYS A 186
ASN A  53
PRO A 184
ALA A 185
 None
 1.49A 2ejgB-4iy9A:
undetectable		 2ejgB-4iy9A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfe ENOYL-COA HYDRATASE

(Mycolicibacterium
smegmatis) 		PF00378
(ECH_1) 		4 GLU A  73
ASN A  75
PRO A  30
ALA A  32
 None
 1.20A 2ejgB-4qfeA:
undetectable		 2ejgB-4qfeA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qjy GH127
BETA-L-ARABINOFURANO
SIDASE

(Geobacillus
stearothermophilus) 		PF07944
(Glyco_hydro_127) 		4 GLU A 595
LYS A 574
PRO A 570
ALA A 573
 None
 1.35A 2ejgB-4qjyA:
undetectable		 2ejgB-4qjyA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhh BETA-XYLOSIDASE

(Geobacillus
stearothermophilus) 		PF03512
(Glyco_hydro_52) 		4 GLU A 133
LYS A 121
PRO A 124
ALA A 122
 None
 1.48A 2ejgB-4rhhA:
undetectable		 2ejgB-4rhhA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ru0 PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC
BRANCHED-CHAIN AMINO
ACID-BINDING PROTEIN

(Pseudomonas
protegens) 		PF13458
(Peripla_BP_6) 		4 ARG A 419
GLU A 389
PRO A 149
ALA A 138
 None
 1.33A 2ejgB-4ru0A:
undetectable		 2ejgB-4ru0A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tpn PUTATIVE P450-LIKE
PROTEIN

(Streptomyces
scabiei) 		PF00067
(p450) 		4 ARG A 326
GLU A 285
ASN A 265
ALA A 261
 None
 1.12A 2ejgB-4tpnA:
undetectable		 2ejgB-4tpnA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans) 		PF01450
(IlvC)
PF07991
(IlvN) 		4 GLU A  13
LYS A 170
PRO A  14
ALA A 167
 None
 1.38A 2ejgB-4xehA:
undetectable		 2ejgB-4xehA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xj5 CYCLIC AMP-GMP
SYNTHASE

(Vibrio cholerae) 		no annotation 4 GLU A 375
LYS A 327
PRO A 374
ALA A 330
 None
 1.49A 2ejgB-4xj5A:
undetectable		 2ejgB-4xj5A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xr7 PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3

(Saccharomyces
cerevisiae) 		no annotation 4 ARG L 430
TRP L 429
GLU L 481
ASN L 489
 None
 1.33A 2ejgB-4xr7L:
undetectable		 2ejgB-4xr7L:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zi5 P91

(metagenome) 		PF01738
(DLH) 		4 LYS A  46
ASN A  42
PRO A  36
ALA A  45
 None
 1.35A 2ejgB-4zi5A:
undetectable		 2ejgB-4zi5A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpq MCG133388, ISOFORM
CRA_F

(Mus musculus) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		4 ARG A 294
ASN A 207
PRO A 211
ALA A 210
 None
CA  A 401 (-3.3A)
None
None
 1.35A 2ejgB-4zpqA:
undetectable		 2ejgB-4zpqA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zrm UDP-GLUCOSE
4-EPIMERASE

(Thermotoga
maritima) 		PF01370
(Epimerase) 		4 GLU A 135
LYS A 280
ASN A 235
PRO A 132
 None
 1.36A 2ejgB-4zrmA:
undetectable		 2ejgB-4zrmA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2o NITRATE TRANSPORTER
1.1

(Arabidopsis
thaliana) 		PF00854
(PTR2) 		4 GLU A 368
ASN A  54
PRO A 381
ALA A 382
 None
 1.44A 2ejgB-5a2oA:
undetectable		 2ejgB-5a2oA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7d INSCUTEABLE
PINS

(Drosophila
melanogaster) 		PF13176
(TPR_7)
PF13424
(TPR_12)
no annotation 		4 ARG B 339
TRP L 313
ASN B 266
ALA L 320
 None
 1.28A 2ejgB-5a7dB:
undetectable		 2ejgB-5a7dB:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aga DNA POLYMERASE THETA

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 GLU A 217
LYS A 153
PRO A 145
ALA A 150
 ANP  A1892 ( 4.5A)
None
None
None
 1.47A 2ejgB-5agaA:
undetectable		 2ejgB-5agaA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b64 PROTEIN KIF13B

(Mus musculus) 		PF12423
(KIF1B) 		4 GLU B 736
LYS B 692
PRO B 737
ALA B 693
 None
 1.45A 2ejgB-5b64B:
undetectable		 2ejgB-5b64B:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9a RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza C
virus) 		PF00602
(Flu_PB1) 		4 GLU B 489
ASN B 292
PRO B 488
ALA B 301
 None
 1.17A 2ejgB-5d9aB:
1.6		 2ejgB-5d9aB:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9n B-1,4-ENDOGLUCANASE

(Prevotella
bryantii) 		PF00150
(Cellulase) 		4 ARG A 194
GLU A  10
ASN A 231
ALA A  13
 None
 1.47A 2ejgB-5d9nA:
undetectable		 2ejgB-5d9nA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dd4 TRANSCRIPTIONAL
REGULATOR ARAR

(Bacteroides
thetaiotaomicron) 		PF00293
(NUDIX) 		4 ARG A 218
GLU A 149
ASN A 154
PRO A 150
 None
 1.29A 2ejgB-5dd4A:
undetectable		 2ejgB-5dd4A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4r KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans) 		PF01450
(IlvC)
PF07991
(IlvN) 		4 GLU A  13
LYS A 170
PRO A  14
ALA A 167
 None
GOL  A 506 (-4.6A)
None
None
 1.36A 2ejgB-5e4rA:
undetectable		 2ejgB-5e4rA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ex6 CYTOCHROME P450

(Streptomyces
toyocaensis) 		no annotation 4 ARG C 317
GLU C 275
ASN C 255
ALA C 251
 None
 1.13A 2ejgB-5ex6C:
undetectable		 2ejgB-5ex6C:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjw VOLTAGE-DEPENDENT
CALCIUM CHANNEL
SUBUNIT
ALPHA-2/DELTA-1

(Oryctolagus
cuniculus) 		PF00092
(VWA)
PF08399
(VWA_N)
PF08473
(VGCC_alpha2) 		4 GLU F 414
ASN F 424
PRO F 416
ALA F 420
 None
 1.11A 2ejgB-5gjwF:
undetectable		 2ejgB-5gjwF:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5huc 3-DEOXY-D-ARABINO-HE
PTULOSONATE
7-PHOSPHATE (DAHP)
SYNTHASE

(Corynebacterium
glutamicum) 		PF01474
(DAHP_synth_2) 		4 ARG A 136
TRP A 290
PRO A 144
ALA A 142
 PEP  A 502 (-2.7A)
PEP  A 502 (-4.7A)
None
None
 1.45A 2ejgB-5hucA:
undetectable		 2ejgB-5hucA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikj CRYPTIC LOCI
REGULATOR 2

(Schizosaccharomyces
pombe) 		PF10383
(Clr2)
PF16761
(Clr2_transil) 		4 GLU A 312
LYS A 282
PRO A 247
ALA A 248
 None
 1.09A 2ejgB-5ikjA:
undetectable		 2ejgB-5ikjA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jp0 BETA-GLUCOSIDASE
BOGH3B

(Bacteroides
ovatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 GLU A 227
LYS A 165
ASN A 229
ALA A 168
 None
 1.41A 2ejgB-5jp0A:
undetectable		 2ejgB-5jp0A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqm GLYCOSYL HYDROLASES
FAMILY 2, SUGAR
BINDING DOMAIN

(Bacteroides
thetaiotaomicron) 		PF17132
(Glyco_hydro_106) 		4 GLU A 865
ASN A 862
PRO A 912
ALA A 911
 None
 1.44A 2ejgB-5mqmA:
undetectable		 2ejgB-5mqmA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhu MYCINAMICIN IV
HYDROXYLASE/EPOXIDAS
E

(Micromonospora
griseorubida) 		PF00067
(p450) 		4 ARG A  69
GLU A  71
PRO A  72
ALA A  43
 None
 1.21A 2ejgB-5uhuA:
undetectable		 2ejgB-5uhuA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyl INNER TEGUMENT
PROTEIN

(Human
alphaherpesvirus
1) 		PF03970
(Herpes_UL37_1) 		4 ARG A 553
GLU A 102
PRO A 101
ALA A 540
 None
 1.19A 2ejgB-5vylA:
undetectable		 2ejgB-5vylA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xb7 BETA-GALACTOSIDASE

(Bifidobacterium
animalis) 		no annotation 4 GLU A 251
LYS A 153
PRO A 261
ALA A 262
 None
 1.26A 2ejgB-5xb7A:
1.7		 2ejgB-5xb7A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xeo CYSTEINE SYNTHASE

(Fusobacterium
nucleatum) 		no annotation 4 GLU A 280
LYS A 284
ASN A  26
ALA A 282
 None
 1.46A 2ejgB-5xeoA:
undetectable		 2ejgB-5xeoA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194) 		4 ARG C  70
GLU C  80
PRO C 126
ALA C 127
 None
 1.36A 2ejgB-5y3rC:
undetectable		 2ejgB-5y3rC:
5.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bv2 AMINOPEPTIDASE N

(Sus scrofa) 		no annotation 4 TRP A 636
GLU A 633
PRO A 672
ALA A 666
 None
 1.38A 2ejgB-6bv2A:
undetectable		 2ejgB-6bv2A:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ck0 BIOTIN ACETYL
COENZYME A
CARBOXYLASE
SYNTHETASE

(Helicobacter
pylori) 		no annotation 4 TRP A  50
GLU A  51
LYS A 110
ASN A 130
 F5D  A 301 (-3.8A)
F5D  A 301 (-4.7A)
F5D  A 301 (-2.5A)
F5D  A 301 (-3.0A)
 1.05A 2ejgB-6ck0A:
18.8		 2ejgB-6ck0A:
14.04