SIMILAR PATTERNS OF AMINO ACIDS FOR 2EJG_A_ADNA1501_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b9r PROTEIN
(TERPREDOXIN)

(Pseudomonas sp.) 		PF00111
(Fer2) 		4 ARG A  83
GLU A  25
ASN A  30
ALA A  17
 None
 1.36A 2ejgA-1b9rA:
undetectable		 2ejgA-1b9rA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gnx BETA-GLUCOSIDASE

(Streptomyces
sp.) 		PF00232
(Glyco_hydro_1) 		4 GLU A 402
LYS A 461
PRO A 401
ALA A 462
 None
 1.36A 2ejgA-1gnxA:
0.0		 2ejgA-1gnxA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i9a ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE

(Escherichia
coli) 		PF00293
(NUDIX) 		4 ARG A  83
GLU A  77
PRO A  95
ALA A 123
 None
 1.28A 2ejgA-1i9aA:
undetectable		 2ejgA-1i9aA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uf2 OUTER CAPSID PROTEIN
P8

(Rice dwarf
virus) 		no annotation 4 ARG P 189
GLU P 296
LYS P 129
PRO P 150
 None
 1.25A 2ejgA-1uf2P:
undetectable		 2ejgA-1uf2P:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urj MAJOR DNA-BINDING
PROTEIN

(Human
alphaherpesvirus
1) 		PF00747
(Viral_DNA_bp) 		4 ARG A 147
GLU A 142
PRO A 152
ALA A 155
 None
 1.37A 2ejgA-1urjA:
0.0		 2ejgA-1urjA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6t HYPOTHETICAL UPF0271
PROTEIN PH0986

(Pyrococcus
horikoshii) 		PF03746
(LamB_YcsF) 		4 ARG A 168
GLU A 187
ASN A 226
ALA A 229
 None
 1.17A 2ejgA-1v6tA:
undetectable		 2ejgA-1v6tA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vzh DESULFOFERRODOXIN

(Desulfarculus
baarsii) 		PF01880
(Desulfoferrodox)
PF06397
(Desulfoferrod_N) 		4 GLU A 114
ASN A  40
PRO A  51
ALA A 124
 None
 1.08A 2ejgA-1vzhA:
undetectable		 2ejgA-1vzhA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wxp THO COMPLEX SUBUNIT
1

(Homo sapiens) 		PF00531
(Death) 		4 ARG A  47
GLU A  45
LYS A  33
ALA A  36
 None
 1.36A 2ejgA-1wxpA:
undetectable		 2ejgA-1wxpA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x87 UROCANASE PROTEIN

(Geobacillus
stearothermophilus) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		4 ARG A 404
GLU A 146
ASN A 184
ALA A 180
 None
 1.09A 2ejgA-1x87A:
undetectable		 2ejgA-1x87A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8x UBIQUITIN-CONJUGATIN
G ENZYME E2 M

(Homo sapiens) 		PF00179
(UQ_con) 		4 GLU A 142
LYS A 147
PRO A 141
ALA A 150
 None
 1.09A 2ejgA-1y8xA:
0.2		 2ejgA-1y8xA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ycd HYPOTHETICAL 27.3
KDA PROTEIN IN
AAP1-SMF2 INTERGENIC
REGION

(Saccharomyces
cerevisiae) 		PF03959
(FSH1) 		4 LYS A 200
ASN A 203
PRO A 169
ALA A 201
 None
 1.08A 2ejgA-1ycdA:
undetectable		 2ejgA-1ycdA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE

(Deinococcus
radiodurans) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48)
PF11941
(DUF3459) 		4 ARG A 361
GLU A 533
ASN A 529
ALA A 389
 None
 1.28A 2ejgA-2bxyA:
undetectable		 2ejgA-2bxyA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxe RIBULOSE
BISPHOSPHATE
CARBOXYLASE

(Pyrococcus
horikoshii) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 GLU A  20
LYS A  71
PRO A  21
ALA A  87
 None
 1.33A 2ejgA-2cxeA:
undetectable		 2ejgA-2cxeA:
21.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2djz 235AA LONG
HYPOTHETICAL
BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE

(Pyrococcus
horikoshii) 		PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB) 		4 ARG A  48
TRP A  53
ASN A 131
ALA A 111
 None
BT5  A1301 (-3.8A)
BT5  A1301 (-3.0A)
BT5  A1301 ( 3.8A)
 1.18A 2ejgA-2djzA:
38.4		 2ejgA-2djzA:
99.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2djz 235AA LONG
HYPOTHETICAL
BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE

(Pyrococcus
horikoshii) 		PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB) 		6 ARG A  51
TRP A  53
GLU A  54
ASN A 131
PRO A 137
ALA A 140
 BT5  A1301 (-4.0A)
BT5  A1301 (-3.8A)
None
BT5  A1301 (-3.0A)
BT5  A1301 (-4.6A)
BT5  A1301 (-3.4A)
 0.50A 2ejgA-2djzA:
38.4		 2ejgA-2djzA:
99.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ecf DIPEPTIDYL PEPTIDASE
IV

(Stenotrophomonas
maltophilia) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 TRP A 639
ASN A 611
PRO A 527
ALA A 528
 None
 1.02A 2ejgA-2ecfA:
undetectable		 2ejgA-2ecfA:
15.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ej9 PUTATIVE BIOTIN
LIGASE

(Methanocaldococcus
jannaschii) 		PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB) 		4 TRP A  45
LYS A 106
ASN A 126
ALA A 139
 BTN  A1301 (-3.9A)
BTN  A1301 (-2.6A)
None
None
 0.32A 2ejgA-2ej9A:
26.0		 2ejgA-2ej9A:
37.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2et6 (3R)-HYDROXYACYL-COA
DEHYDROGENASE

(Candida
tropicalis) 		PF00106
(adh_short) 		4 ARG A 247
TRP A 552
GLU A 237
ALA A 190
 None
 1.11A 2ejgA-2et6A:
undetectable		 2ejgA-2et6A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ewn BIRA BIFUNCTIONAL
PROTEIN

(Escherichia
coli) 		PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB)
PF08279
(HTH_11) 		4 ARG A 121
TRP A 123
LYS A 183
ASN A 208
 BTX  A 501 (-4.1A)
BTX  A 501 (-3.6A)
BTX  A 501 ( 3.7A)
BTX  A 501 (-2.9A)
 0.98A 2ejgA-2ewnA:
26.7		 2ejgA-2ewnA:
27.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gks BIFUNCTIONAL SAT/APS
KINASE

(Aquifex
aeolicus) 		PF01583
(APS_kinase)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 ARG A 266
GLU A 285
PRO A 244
ALA A 247
 ADP  A 902 (-4.3A)
None
None
None
 1.04A 2ejgA-2gksA:
undetectable		 2ejgA-2gksA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hyx PROTEIN DIPZ

(Mycobacterium
tuberculosis) 		PF00578
(AhpC-TSA) 		4 GLU A 527
LYS A 524
PRO A 509
ALA A 510
 None
 1.31A 2ejgA-2hyxA:
undetectable		 2ejgA-2hyxA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9e TRIOSEPHOSPHATE
ISOMERASE

(Tenebrio
molitor) 		PF00121
(TIM) 		4 ARG A 246
GLU A 218
PRO A 177
ALA A 180
 None
 1.15A 2ejgA-2i9eA:
undetectable		 2ejgA-2i9eA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q17 FORMYLGLYCINE
GENERATING ENZYME

(Streptomyces
coelicolor) 		PF03781
(FGE-sulfatase) 		4 ARG A  28
GLU A  64
ASN A 222
ALA A 169
 None
 1.31A 2ejgA-2q17A:
undetectable		 2ejgA-2q17A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7g UROCANATE HYDRATASE

(Pseudomonas
putida) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		4 ARG A   8
GLU A  11
PRO A  40
ALA A  43
 None
 1.18A 2ejgA-2v7gA:
undetectable		 2ejgA-2v7gA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsq SURFACTIN SYNTHETASE
SUBUNIT 3

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		4 ARG A 987
GLU A 983
LYS A1005
ALA A1009
 None
 1.19A 2ejgA-2vsqA:
undetectable		 2ejgA-2vsqA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wj3 1-H-3-HYDROXY-4-OXOQ
UINALDINE
2,4-DIOXYGENASE

(Paenarthrobacter
nitroguajacolicus) 		PF00561
(Abhydrolase_1) 		4 ARG A 198
TRP A 105
PRO A 132
ALA A 131
 None
 1.35A 2ejgA-2wj3A:
undetectable		 2ejgA-2wj3A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yvt HYPOTHETICAL PROTEIN
AQ_1956

(Aquifex
aeolicus) 		PF14582
(Metallophos_3) 		4 GLU A  71
ASN A  45
PRO A 102
ALA A 101
 None
 1.29A 2ejgA-2yvtA:
undetectable		 2ejgA-2yvtA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z00 DIHYDROOROTASE

(Thermus
thermophilus) 		PF01979
(Amidohydro_1) 		4 GLU A 205
ASN A 200
PRO A 280
ALA A 279
 None
 1.35A 2ejgA-2z00A:
undetectable		 2ejgA-2z00A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5l TYLACTONE SYNTHASE
STARTER MODULE AND
MODULES 1 & 2

(Streptomyces
fradiae) 		PF08659
(KR) 		4 ARG A 256
GLU A 261
PRO A 237
ALA A 263
 None
 1.35A 2ejgA-2z5lA:
undetectable		 2ejgA-2z5lA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN
PHOTOSYSTEM II D2
PROTEIN

(Thermosynechococcus
vulcanus) 		PF00124
(Photo_RC)
PF00421
(PSII) 		4 ARG D 326
LYS B 321
ASN B 318
ALA B 320
 None
 1.28A 2ejgA-3a0hD:
undetectable		 2ejgA-3a0hD:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aw8 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Thermus
thermophilus) 		PF02222
(ATP-grasp) 		4 ARG A 140
GLU A  68
PRO A 261
ALA A  90
 None
 1.34A 2ejgA-3aw8A:
undetectable		 2ejgA-3aw8A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b70 ENOYL REDUCTASE

(Aspergillus
terreus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ARG A 114
ASN A  49
PRO A 134
ALA A 135
 None
 1.37A 2ejgA-3b70A:
1.0		 2ejgA-3b70A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bf8 ESTERASE YBFF

(Escherichia
coli) 		PF12697
(Abhydrolase_6) 		4 TRP A 188
GLU A 189
PRO A  65
ALA A  68
 None
 1.20A 2ejgA-3bf8A:
undetectable		 2ejgA-3bf8A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eeg 2-ISOPROPYLMALATE
SYNTHASE

(Cytophaga
hutchinsonii) 		PF00682
(HMGL-like) 		4 ARG A  93
GLU A 137
LYS A 130
ALA A 129
 None
 1.32A 2ejgA-3eegA:
undetectable		 2ejgA-3eegA:
22.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3efs BIOTIN
[ACETYL-COA-CARBOXYL
ASE] LIGASE

(Aquifex
aeolicus) 		PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB) 		5 ARG A  43
TRP A  45
LYS A 103
ASN A 123
ALA A 137
 ATP  A1001 (-2.9A)
BTN  A2001 ( 3.7A)
ATP  A1001 ( 3.1A)
ATP  A1001 (-2.8A)
ATP  A1001 (-3.4A)
 0.75A 2ejgA-3efsA:
28.0		 2ejgA-3efsA:
35.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF14710
(Nitr_red_alph_N) 		4 ARG A 584
GLU A 992
ASN A 988
ALA A 986
 None
 1.13A 2ejgA-3egwA:
undetectable		 2ejgA-3egwA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmz RETINOL-BINDING
PROTEIN 4

(Homo sapiens) 		PF00061
(Lipocalin) 		4 ARG A  19
LYS A  12
PRO A  83
ALA A  84
 None
 1.34A 2ejgA-3fmzA:
undetectable		 2ejgA-3fmzA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fse TWO-DOMAIN PROTEIN
CONTAINING
DJ-1/THIJ/PFPI-LIKE
AND FERRITIN-LIKE
DOMAINS

(Trichormus
variabilis) 		PF01965
(DJ-1_PfpI)
PF09537
(DUF2383) 		4 ARG A 264
GLU A 259
ASN A 215
PRO A 269
 None
 1.16A 2ejgA-3fseA:
undetectable		 2ejgA-3fseA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gri DIHYDROOROTASE

(Staphylococcus
aureus) 		PF01979
(Amidohydro_1) 		4 ARG A 309
GLU A 311
PRO A 320
ALA A 271
 None
 1.25A 2ejgA-3griA:
undetectable		 2ejgA-3griA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT

(Eubacterium
barkeri) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 GLU A 128
ASN A 149
PRO A 142
ALA A 143
 None
 1.25A 2ejgA-3hrdA:
undetectable		 2ejgA-3hrdA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 3

(Thermus
thermophilus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
PF10588
(NADH-G_4Fe-4S_3)
PF13510
(Fer2_4) 		4 ARG 3 679
GLU 3 682
PRO 3 378
ALA 3 377
 None
 1.35A 2ejgA-3i9v3:
undetectable		 2ejgA-3i9v3:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ib3 COCE/NOND FAMILY
HYDROLASE

(Staphylococcus
aureus) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		4 ARG A 297
GLU A 299
ASN A 275
ALA A 266
 None
 1.36A 2ejgA-3ib3A:
undetectable		 2ejgA-3ib3A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icx PRE MRNA SPLICING
PROTEIN

(Sulfolobus
solfataricus) 		PF01798
(Nop) 		4 ARG A 248
GLU A 255
PRO A 271
ALA A 272
 SO4  A 501 (-3.2A)
None
None
None
 1.35A 2ejgA-3icxA:
undetectable		 2ejgA-3icxA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Thermus
thermophilus) 		PF01425
(Amidase) 		4 TRP E 284
GLU E 252
PRO E 288
ALA E 290
 None
 1.35A 2ejgA-3kfuE:
undetectable		 2ejgA-3kfuE:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kuq RHO
GTPASE-ACTIVATING
PROTEIN 7

(Homo sapiens) 		PF00620
(RhoGAP) 		4 ARG A1114
ASN A1266
PRO A1231
ALA A1230
 None
 1.01A 2ejgA-3kuqA:
undetectable		 2ejgA-3kuqA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmm UNCHARACTERIZED
PROTEIN

(Corynebacterium
diphtheriae) 		PF04326
(AlbA_2)
PF13749
(HATPase_c_4) 		4 ARG A 352
GLU A 142
ASN A  77
ALA A  73
 None
 1.20A 2ejgA-3lmmA:
undetectable		 2ejgA-3lmmA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3k UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 8

(Homo sapiens) 		PF00443
(UCH) 		4 ARG A 807
ASN A1074
PRO A 774
ALA A 775
 None
 1.01A 2ejgA-3n3kA:
undetectable		 2ejgA-3n3kA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nv9 MALIC ENZYME

(Entamoeba
histolytica) 		PF00390
(malic)
PF03949
(Malic_M) 		4 GLU A 446
LYS A 368
PRO A 415
ALA A 418
 None
 1.14A 2ejgA-3nv9A:
undetectable		 2ejgA-3nv9A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwp 6-PHOSPHOGLUCONOLACT
ONASE

(Shewanella
baltica) 		PF01182
(Glucosamine_iso) 		4 TRP A  74
GLU A  72
ASN A 106
ALA A 118
 None
 1.15A 2ejgA-3nwpA:
undetectable		 2ejgA-3nwpA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pm6 PUTATIVE
FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Coccidioides
immitis) 		PF01116
(F_bP_aldolase) 		4 ARG A 209
ASN A 190
PRO A 186
ALA A 187
 IOD  A 308 ( 4.9A)
None
None
None
 1.31A 2ejgA-3pm6A:
undetectable		 2ejgA-3pm6A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppx VON WILLEBRAND
FACTOR

(Homo sapiens) 		PF00092
(VWA) 		4 ARG A1516
GLU A1523
PRO A1662
ALA A1661
 None
 1.36A 2ejgA-3ppxA:
undetectable		 2ejgA-3ppxA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qka ENOYL-COA HYDRATASE,
ECHA5

(Mycobacterium
marinum) 		PF00378
(ECH_1) 		4 GLU A  73
ASN A  75
PRO A  30
ALA A  32
 None
 1.11A 2ejgA-3qkaA:
undetectable		 2ejgA-3qkaA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqv GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Corynebacterium
glutamicum) 		PF00348
(polyprenyl_synt) 		4 ARG A 184
GLU A  98
PRO A  67
ALA A  70
 None
 1.29A 2ejgA-3qqvA:
undetectable		 2ejgA-3qqvA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rd7 ACYL-COA
THIOESTERASE

(Mycobacterium
avium) 		PF13622
(4HBT_3) 		4 ARG A 177
GLU A 207
PRO A 162
ALA A 165
 None
 1.14A 2ejgA-3rd7A:
undetectable		 2ejgA-3rd7A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u95 GLYCOSIDE HYDROLASE,
FAMILY 4

(Thermotoga
neapolitana) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		4 GLU A 394
ASN A 215
PRO A 383
ALA A 206
 None
 1.22A 2ejgA-3u95A:
undetectable		 2ejgA-3u95A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uxj NADPH-DEPENDENT
7-CYANO-7-DEAZAGUANI
NE REDUCTASE

(Vibrio cholerae) 		PF14489
(QueF)
PF14819
(QueF_N) 		4 ARG A 239
GLU A 234
PRO A 269
ALA A 257
 None
PRF  A1194 (-3.0A)
None
None
 1.12A 2ejgA-3uxjA:
undetectable		 2ejgA-3uxjA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vr1 PEPTIDE CHAIN
RELEASE FACTOR 3

(Desulfovibrio
vulgaris) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF16658
(RF3_C) 		4 ARG A 516
GLU A 511
ASN A 506
ALA A 504
 None
 1.33A 2ejgA-3vr1A:
undetectable		 2ejgA-3vr1A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vva ALTERNATIVE OXIDASE,
MITOCHONDRIAL

(Trypanosoma
brucei) 		PF01786
(AOX) 		4 ARG A 173
GLU A 171
LYS A 236
PRO A 240
 None
 1.07A 2ejgA-3vvaA:
undetectable		 2ejgA-3vvaA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vwo PEPTIDOGLYCAN
HYDROLASE FLGJ

(Sphingomonas
sp. A1) 		PF01832
(Glucosaminidase) 		4 ARG A 233
GLU A 219
LYS A 208
ALA A 209
 None
None
EPE  A 401 ( 4.3A)
None
 1.10A 2ejgA-3vwoA:
undetectable		 2ejgA-3vwoA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdg URACIL-DNA
GLYCOSYLASE

(Staphylococcus
aureus) 		PF03167
(UDG) 		4 ARG A  99
GLU A  90
PRO A 195
ALA A 199
 None
 1.18A 2ejgA-3wdgA:
undetectable		 2ejgA-3wdgA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zok 3-DEHYDROQUINATE
SYNTHASE

(Actinidia
chinensis) 		PF01761
(DHQ_synthase) 		4 LYS A  64
ASN A  71
PRO A  37
ALA A  68
 None
 1.34A 2ejgA-3zokA:
undetectable		 2ejgA-3zokA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4at0 3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E

(Rhodococcus
jostii) 		PF00890
(FAD_binding_2) 		4 ARG A 302
LYS A 409
ASN A 390
ALA A 393
 None
 1.32A 2ejgA-4at0A:
undetectable		 2ejgA-4at0A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE

(Trypanosoma
brucei) 		PF01704
(UDPGP) 		4 ARG A  93
GLU A  98
ASN A 283
PRO A 287
 None
 1.01A 2ejgA-4bqhA:
undetectable		 2ejgA-4bqhA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmc RORF2

(Escherichia
coli) 		PF06872
(EspG) 		4 ARG A 387
ASN A 296
PRO A 298
ALA A 299
 None
 1.10A 2ejgA-4fmcA:
undetectable		 2ejgA-4fmcA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gkl ALPHA-AMYLASE

(Thermotoga
neapolitana) 		PF00128
(Alpha-amylase) 		4 ARG A 267
GLU A 413
PRO A 414
ALA A 275
 None
 1.33A 2ejgA-4gklA:
undetectable		 2ejgA-4gklA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gz8 SEMAPHORIN-3A

(Mus musculus) 		PF01403
(Sema) 		4 ARG A 100
GLU A 113
LYS A  74
PRO A 173
 None
 1.12A 2ejgA-4gz8A:
undetectable		 2ejgA-4gz8A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h6a ALLENE OXIDE CYCLASE

(Physcomitrella
patens) 		PF06351
(Allene_ox_cyc) 		4 GLU A 169
LYS A 176
PRO A 170
ALA A 174
 None
 1.34A 2ejgA-4h6aA:
undetectable		 2ejgA-4h6aA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hrw CYTIDINE AND
DEOXYCYTIDYLATE
DEAMINASE
ZINC-BINDING REGION

(Nitrosomonas
europaea) 		PF00383
(dCMP_cyt_deam_1) 		4 ARG A  72
ASN A  40
PRO A  10
ALA A  43
 None
 1.35A 2ejgA-4hrwA:
undetectable		 2ejgA-4hrwA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcs ENOYL-COA
HYDRATASE/ISOMERASE

(Cupriavidus
metallidurans) 		PF00378
(ECH_1) 		4 ARG A 191
GLU A 184
PRO A 126
ALA A 170
 None
 1.23A 2ejgA-4jcsA:
undetectable		 2ejgA-4jcsA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jn7 ENOLASE

(Agrobacterium
tumefaciens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ARG A 220
TRP A 227
PRO A 197
ALA A 200
 None
 1.33A 2ejgA-4jn7A:
undetectable		 2ejgA-4jn7A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4js5 EXODEOXYRIBONUCLEASE
I

(Escherichia
coli) 		PF00929
(RNase_T)
PF08411
(Exonuc_X-T_C) 		4 ARG A  87
GLU A  81
PRO A  28
ALA A  29
 None
 1.08A 2ejgA-4js5A:
2.1		 2ejgA-4js5A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l0c DEFORMYLASE

(Pseudomonas
putida) 		PF12697
(Abhydrolase_6) 		4 GLU A 211
LYS A 132
PRO A 130
ALA A 131
 None
 1.36A 2ejgA-4l0cA:
undetectable		 2ejgA-4l0cA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lw8 PUTATIVE EPIMERASE

(Burkholderia
cenocepacia) 		PF01370
(Epimerase) 		4 ARG A 290
GLU A 237
PRO A 234
ALA A 232
 None
EPE  A 400 (-2.9A)
None
None
 1.28A 2ejgA-4lw8A:
undetectable		 2ejgA-4lw8A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oj5 TAILSPIKE PROTEIN

(Escherichia
virus CBA120) 		no annotation 4 ARG A 467
ASN A 531
PRO A 526
ALA A 529
 None
 1.11A 2ejgA-4oj5A:
undetectable		 2ejgA-4oj5A:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4paf TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE

(Ruegeria
pomeroyi) 		PF03480
(DctP) 		4 ARG A 127
GLU A 318
ASN A 101
ALA A 104
 None
 1.13A 2ejgA-4pafA:
undetectable		 2ejgA-4pafA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3m MGS-M4

(unidentified) 		PF00248
(Aldo_ket_red) 		4 GLU A  11
LYS A 131
ASN A   8
ALA A 132
 None
 1.34A 2ejgA-4q3mA:
undetectable		 2ejgA-4q3mA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfe ENOYL-COA HYDRATASE

(Mycolicibacterium
smegmatis) 		PF00378
(ECH_1) 		4 GLU A  73
ASN A  75
PRO A  30
ALA A  32
 None
 1.20A 2ejgA-4qfeA:
undetectable		 2ejgA-4qfeA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qjy GH127
BETA-L-ARABINOFURANO
SIDASE

(Geobacillus
stearothermophilus) 		PF07944
(Glyco_hydro_127) 		4 GLU A 595
LYS A 574
PRO A 570
ALA A 573
 None
 1.27A 2ejgA-4qjyA:
undetectable		 2ejgA-4qjyA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r04 TOXIN A

(Clostridioides
difficile) 		PF11713
(Peptidase_C80)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
PF12920
(TcdA_TcdB_pore) 		4 ARG A 310
TRP A 311
GLU A 312
ALA A 318
 None
 1.36A 2ejgA-4r04A:
undetectable		 2ejgA-4r04A:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhh BETA-XYLOSIDASE

(Geobacillus
stearothermophilus) 		PF03512
(Glyco_hydro_52) 		4 GLU A 133
LYS A 121
PRO A 124
ALA A 122
 None
 1.34A 2ejgA-4rhhA:
undetectable		 2ejgA-4rhhA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x3f SERINE/THREONINE-PRO
TEIN KINASE PKNA

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase) 		4 ARG A 260
GLU A 247
PRO A 280
ALA A 270
 None
 1.35A 2ejgA-4x3fA:
2.1		 2ejgA-4x3fA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xeh KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans) 		PF01450
(IlvC)
PF07991
(IlvN) 		4 GLU A  13
LYS A 170
PRO A  14
ALA A 167
 None
 1.32A 2ejgA-4xehA:
undetectable		 2ejgA-4xehA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yry DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT
HOMOLOG

(Thermotoga
maritima) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6)
PF10418
(DHODB_Fe-S_bind) 		4 ARG A  65
LYS A 123
PRO A  35
ALA A 124
 None
 1.29A 2ejgA-4yryA:
undetectable		 2ejgA-4yryA:
25.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE

(Rhizomucor
miehei) 		PF00583
(Acetyltransf_1)
PF00933
(Glyco_hydro_3) 		4 ARG A 160
GLU A 167
LYS A 215
ALA A 216
 None
 1.24A 2ejgA-4zm6A:
undetectable		 2ejgA-4zm6A:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c5s UNCONVENTIONAL
MYOSIN-IXB

(Homo sapiens) 		PF00620
(RhoGAP) 		4 ARG A 305
GLU A 297
PRO A 262
ALA A 252
 None
 1.06A 2ejgA-5c5sA:
undetectable		 2ejgA-5c5sA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9a RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza C
virus) 		PF00602
(Flu_PB1) 		4 GLU B 489
ASN B 292
PRO B 488
ALA B 301
 None
 1.21A 2ejgA-5d9aB:
1.4		 2ejgA-5d9aB:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgo CELL DIVISION
CONTROL PROTEIN 45
HOMOLOG

(Homo sapiens) 		PF02724
(CDC45) 		4 ARG A 536
GLU A 531
LYS A 556
ALA A 560
 None
 1.26A 2ejgA-5dgoA:
4.2		 2ejgA-5dgoA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4r KETOL-ACID
REDUCTOISOMERASE

(Ignisphaera
aggregans) 		PF01450
(IlvC)
PF07991
(IlvN) 		4 GLU A  13
LYS A 170
PRO A  14
ALA A 167
 None
GOL  A 506 (-4.6A)
None
None
 1.32A 2ejgA-5e4rA:
undetectable		 2ejgA-5e4rA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f56 SINGLE-STRANDED-DNA-
SPECIFIC EXONUCLEASE

(Deinococcus
radiodurans) 		PF01368
(DHH)
PF02272
(DHHA1) 		4 ARG A  15
TRP A 665
PRO A  12
ALA A 683
 None
 1.33A 2ejgA-5f56A:
3.1		 2ejgA-5f56A:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjw VOLTAGE-DEPENDENT
CALCIUM CHANNEL
SUBUNIT
ALPHA-2/DELTA-1

(Oryctolagus
cuniculus) 		PF00092
(VWA)
PF08399
(VWA_N)
PF08473
(VGCC_alpha2) 		4 GLU F 414
ASN F 424
PRO F 416
ALA F 420
 None
 1.07A 2ejgA-5gjwF:
undetectable		 2ejgA-5gjwF:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF09334
(tRNA-synt_1g) 		4 ARG A 394
ASN A 276
PRO A 329
ALA A 322
 None
 1.29A 2ejgA-5gl7A:
undetectable		 2ejgA-5gl7A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT BETA
T-COMPLEX PROTEIN 1
SUBUNIT EPSILON

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		4 ARG b 516
GLU e  80
LYS b  75
ASN b  79
 None
 1.24A 2ejgA-5gw5b:
undetectable		 2ejgA-5gw5b:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikj CRYPTIC LOCI
REGULATOR 2

(Schizosaccharomyces
pombe) 		PF10383
(Clr2)
PF16761
(Clr2_transil) 		4 GLU A 312
LYS A 282
PRO A 247
ALA A 248
 None
 1.06A 2ejgA-5ikjA:
undetectable		 2ejgA-5ikjA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j72 PUTATIVE
N-ACETYLMURAMOYL-L-A
LANINE
AMIDASE,AUTOLYSIN
CWP6

(Clostridioides
difficile) 		PF01520
(Amidase_3)
PF04122
(CW_binding_2) 		4 ARG A  18
GLU A 118
PRO A 140
ALA A 139
 CL  A 706 (-4.1A)
None
None
None
 1.17A 2ejgA-5j72A:
2.8		 2ejgA-5j72A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jip CORTICAL-LYTIC
ENZYME

(Clostridium
perfringens) 		PF01183
(Glyco_hydro_25) 		4 ARG A 144
GLU A 301
ASN A 254
ALA A 234
 None
 1.25A 2ejgA-5jipA:
undetectable		 2ejgA-5jipA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lx8 SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 ARG A 145
GLU A 143
PRO A 213
ALA A 217
 None
 1.08A 2ejgA-5lx8A:
undetectable		 2ejgA-5lx8A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nzz TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1

(Homo sapiens) 		no annotation 4 ARG A 104
GLU A 269
PRO A 270
ALA A 181
 None
 1.17A 2ejgA-5nzzA:
undetectable		 2ejgA-5nzzA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tv1 BETA-ARRESTIN-2

(Bos taurus) 		no annotation 4 ARG A 323
ASN A 282
PRO A 277
ALA A 255
 None
 1.24A 2ejgA-5tv1A:
undetectable		 2ejgA-5tv1A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xb7 BETA-GALACTOSIDASE

(Bifidobacterium
animalis) 		no annotation 4 GLU A 251
LYS A 153
PRO A 261
ALA A 262
 None
 1.30A 2ejgA-5xb7A:
undetectable		 2ejgA-5xb7A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ck0 BIOTIN ACETYL
COENZYME A
CARBOXYLASE
SYNTHETASE

(Helicobacter
pylori) 		no annotation 4 TRP A  50
GLU A  51
LYS A 110
ASN A 130
 F5D  A 301 (-3.8A)
F5D  A 301 (-4.7A)
F5D  A 301 (-2.5A)
F5D  A 301 (-3.0A)
 1.00A 2ejgA-6ck0A:
20.3		 2ejgA-6ck0A:
14.04