SIMILAR PATTERNS OF AMINO ACIDS FOR 2EJF_B_ADNB2002

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF03173
(CHB_HEX)
PF03174
(CHB_HEX_C) 		4 ARG A 870
GLU A 883
PRO A 195
ALA A 824
 None
 1.44A 2ejfB-1c7tA:
undetectable		 2ejfB-1c7tA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dcn DELTA 2 CRYSTALLIN

(Anas
platyrhynchos) 		PF00206
(Lyase_1)
PF14698
(ASL_C2) 		4 ARG A  35
TRP A  76
GLU A  38
ASN A  94
 None
 1.48A 2ejfB-1dcnA:
undetectable		 2ejfB-1dcnA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3b ATP-DEPENDENT
PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Thermus
thermophilus) 		PF01293
(PEPCK_ATP) 		4 ARG A 275
TRP A 309
ASN A 289
PRO A 278
 None
 1.43A 2ejfB-1j3bA:
undetectable		 2ejfB-1j3bA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ocs SORTING NEXIN GRD19

(Saccharomyces
cerevisiae) 		PF00787
(PX) 		4 GLU A  33
ASN A  67
PRO A  32
ALA A  30
 None
 1.40A 2ejfB-1ocsA:
undetectable		 2ejfB-1ocsA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ser PROTEIN (SERYL-TRNA
SYNTHETASE
(E.C.6.1.1.11))

(Thermus
thermophilus) 		PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N) 		4 ARG A 314
GLU A 317
PRO A 110
ALA A 116
 None
 1.17A 2ejfB-1serA:
4.6		 2ejfB-1serA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urj MAJOR DNA-BINDING
PROTEIN

(Human
alphaherpesvirus
1) 		PF00747
(Viral_DNA_bp) 		4 ARG A 147
GLU A 142
PRO A 152
ALA A 155
 None
 1.47A 2ejfB-1urjA:
0.0		 2ejfB-1urjA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6t HYPOTHETICAL UPF0271
PROTEIN PH0986

(Pyrococcus
horikoshii) 		PF03746
(LamB_YcsF) 		4 ARG A 168
GLU A 187
ASN A 226
ALA A 229
 None
 1.26A 2ejfB-1v6tA:
0.0		 2ejfB-1v6tA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vs3 TRNA PSEUDOURIDINE
SYNTHASE A

(Thermus
thermophilus) 		PF01416
(PseudoU_synth_1) 		4 ARG A  81
GLU A  73
PRO A  71
ALA A  69
 None
 1.47A 2ejfB-1vs3A:
1.9		 2ejfB-1vs3A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vzh DESULFOFERRODOXIN

(Desulfarculus
baarsii) 		PF01880
(Desulfoferrodox)
PF06397
(Desulfoferrod_N) 		4 GLU A 114
ASN A  40
PRO A  51
ALA A 124
 None
 1.13A 2ejfB-1vzhA:
0.2		 2ejfB-1vzhA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wpn MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Bacillus
subtilis) 		PF01368
(DHH) 		4 GLU A  35
ASN A  28
PRO A  36
ALA A  24
 None
 1.43A 2ejfB-1wpnA:
undetectable		 2ejfB-1wpnA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wzc MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE

(Pyrococcus
horikoshii) 		PF08282
(Hydrolase_3) 		4 ARG A  51
GLU A  53
PRO A  19
ALA A  22
 None
 1.47A 2ejfB-1wzcA:
undetectable		 2ejfB-1wzcA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x87 UROCANASE PROTEIN

(Geobacillus
stearothermophilus) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		4 ARG A 404
GLU A 146
ASN A 184
ALA A 180
 None
 1.11A 2ejfB-1x87A:
1.8		 2ejfB-1x87A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xzw PURPLE ACID
PHOSPHATASE

(Ipomoea batatas) 		PF00149
(Metallophos)
PF14008
(Metallophos_C)
PF16656
(Pur_ac_phosph_N) 		4 ARG A 274
GLU A 276
PRO A 121
ALA A 242
 None
 1.48A 2ejfB-1xzwA:
undetectable		 2ejfB-1xzwA:
21.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2djz 235AA LONG
HYPOTHETICAL
BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE

(Pyrococcus
horikoshii) 		PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB) 		4 ARG A  48
TRP A  53
ASN A 131
ALA A 111
 None
BT5  A1301 (-3.8A)
BT5  A1301 (-3.0A)
BT5  A1301 ( 3.8A)
 1.11A 2ejfB-2djzA:
40.1		 2ejfB-2djzA:
99.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2djz 235AA LONG
HYPOTHETICAL
BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE

(Pyrococcus
horikoshii) 		PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB) 		4 ARG A  51
TRP A  53
ASN A 131
ALA A 111
 BT5  A1301 (-4.0A)
BT5  A1301 (-3.8A)
BT5  A1301 (-3.0A)
BT5  A1301 ( 3.8A)
 1.25A 2ejfB-2djzA:
40.1		 2ejfB-2djzA:
99.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2djz 235AA LONG
HYPOTHETICAL
BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE

(Pyrococcus
horikoshii) 		PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB) 		6 ARG A  51
TRP A  53
GLU A  54
ASN A 131
PRO A 137
ALA A 140
 BT5  A1301 (-4.0A)
BT5  A1301 (-3.8A)
None
BT5  A1301 (-3.0A)
BT5  A1301 (-4.6A)
BT5  A1301 (-3.4A)
 0.44A 2ejfB-2djzA:
40.1		 2ejfB-2djzA:
99.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e8y AMYX PROTEIN

(Bacillus
subtilis) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 ARG A 380
ASN A 170
PRO A 122
ALA A 123
 None
 1.28A 2ejfB-2e8yA:
undetectable		 2ejfB-2e8yA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ecf DIPEPTIDYL PEPTIDASE
IV

(Stenotrophomonas
maltophilia) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 TRP A 639
ASN A 611
PRO A 527
ALA A 528
 None
 1.06A 2ejfB-2ecfA:
undetectable		 2ejfB-2ecfA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gks BIFUNCTIONAL SAT/APS
KINASE

(Aquifex
aeolicus) 		PF01583
(APS_kinase)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 ARG A 266
GLU A 285
PRO A 244
ALA A 247
 ADP  A 902 (-4.3A)
None
None
None
 0.96A 2ejfB-2gksA:
undetectable		 2ejfB-2gksA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2haw MANGANESE-DEPENDENT
INORGANIC
PYROPHOSPHATASE

(Bacillus
subtilis) 		PF01368
(DHH)
PF02833
(DHHA2) 		4 GLU A  35
ASN A  28
PRO A  36
ALA A  24
 None
 1.44A 2ejfB-2hawA:
undetectable		 2ejfB-2hawA:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9e TRIOSEPHOSPHATE
ISOMERASE

(Tenebrio
molitor) 		PF00121
(TIM) 		4 ARG A 246
GLU A 218
PRO A 177
ALA A 180
 None
 1.17A 2ejfB-2i9eA:
undetectable		 2ejfB-2i9eA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuk SEED LIPOXYGENASE

(Glycine max) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 ARG A 782
GLU A 787
PRO A 859
ALA A 717
 None
 1.46A 2ejfB-2iukA:
undetectable		 2ejfB-2iukA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q17 FORMYLGLYCINE
GENERATING ENZYME

(Streptomyces
coelicolor) 		PF03781
(FGE-sulfatase) 		4 ARG A  28
GLU A  64
ASN A 222
ALA A 169
 None
 1.38A 2ejfB-2q17A:
undetectable		 2ejfB-2q17A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpt EH DOMAIN-CONTAINING
PROTEIN-2

(Mus musculus) 		PF00350
(Dynamin_N)
PF12763
(EF-hand_4)
PF16880
(EHD_N) 		4 ARG A 208
GLU A 202
PRO A 172
ALA A 173
 None
 1.48A 2ejfB-2qptA:
undetectable		 2ejfB-2qptA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uyo HYPOTHETICAL PROTEIN
ML2640

(Mycobacterium
leprae) 		PF04072
(LCM) 		4 ARG A 163
GLU A 203
PRO A 167
ALA A 169
 None
 1.40A 2ejfB-2uyoA:
undetectable		 2ejfB-2uyoA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7g UROCANATE HYDRATASE

(Pseudomonas
putida) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		4 ARG A   8
GLU A  11
PRO A  40
ALA A  43
 None
 1.14A 2ejfB-2v7gA:
0.9		 2ejfB-2v7gA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7d 3-KETO-5-AMINOHEXANO
ATE CLEAVAGE ENZYME

(Candidatus
Cloacimonas
acidaminovorans) 		PF05853
(BKACE) 		4 ARG A  71
GLU A  76
PRO A 265
ALA A 268
 None
 1.41A 2ejfB-2y7dA:
undetectable		 2ejfB-2y7dA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yoc PULLULANASE

(Klebsiella
oxytoca) 		PF02922
(CBM_48)
PF03714
(PUD)
PF11852
(DUF3372) 		4 ARG A 640
GLU A 638
PRO A 671
ALA A 673
 None
 1.44A 2ejfB-2yocA:
undetectable		 2ejfB-2yocA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yvt HYPOTHETICAL PROTEIN
AQ_1956

(Aquifex
aeolicus) 		PF14582
(Metallophos_3) 		4 GLU A  71
ASN A  45
PRO A 102
ALA A 101
 None
 1.31A 2ejfB-2yvtA:
undetectable		 2ejfB-2yvtA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywg GTP-BINDING PROTEIN
LEPA

(Aquifex
aeolicus) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF06421
(LepA_C) 		4 ARG A 144
GLU A 150
PRO A 157
ALA A 160
 None
 1.37A 2ejfB-2ywgA:
undetectable		 2ejfB-2ywgA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2m PENICILLIN-BINDING
PROTEIN 2X

(Streptococcus
pneumoniae) 		PF03717
(PBP_dimer) 		4 ARG A  76
GLU A  89
ASN A 190
PRO A  86
 None
 1.41A 2ejfB-2z2mA:
undetectable		 2ejfB-2z2mA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aw8 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Thermus
thermophilus) 		PF02222
(ATP-grasp) 		4 ARG A 140
GLU A  68
PRO A 261
ALA A  90
 None
 1.31A 2ejfB-3aw8A:
undetectable		 2ejfB-3aw8A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bf8 ESTERASE YBFF

(Escherichia
coli) 		PF12697
(Abhydrolase_6) 		4 TRP A 188
GLU A 189
PRO A  65
ALA A  68
 None
 1.34A 2ejfB-3bf8A:
undetectable		 2ejfB-3bf8A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cin MYO-INOSITOL-1-PHOSP
HATE
SYNTHASE-RELATED
PROTEIN

(Thermotoga
maritima) 		PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5) 		4 GLU A 359
ASN A 347
PRO A 356
ALA A 188
 None
 1.49A 2ejfB-3cinA:
undetectable		 2ejfB-3cinA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ec4 PUTATIVE
ACETYLTRANSFERASE
FROM THE GNAT FAMILY

(Novosphingobium
aromaticivorans) 		PF08445
(FR47) 		4 ARG A 216
ASN A 155
PRO A 152
ALA A 153
 None
 1.38A 2ejfB-3ec4A:
undetectable		 2ejfB-3ec4A:
21.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3efs BIOTIN
[ACETYL-COA-CARBOXYL
ASE] LIGASE

(Aquifex
aeolicus) 		PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB) 		4 ARG A  43
TRP A  45
ASN A 123
ALA A 137
 ATP  A1001 (-2.9A)
BTN  A2001 ( 3.7A)
ATP  A1001 (-2.8A)
ATP  A1001 (-3.4A)
 0.42A 2ejfB-3efsA:
28.5		 2ejfB-3efsA:
34.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF14710
(Nitr_red_alph_N) 		4 ARG A 584
GLU A 992
ASN A 988
ALA A 986
 None
 1.22A 2ejfB-3egwA:
undetectable		 2ejfB-3egwA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3err FUSION PROTEIN OF
MICROTUBULE BINDING
DOMAIN FROM MOUSE
CYTOPLASMIC DYNEIN
AND SERYL-TRNA
SYNTHETASE FROM
THERMUS THERMOPHILUS

(Mus musculus;
Thermus
thermophilus) 		PF00587
(tRNA-synt_2b)
PF12777
(MT) 		4 ARG A 314
GLU A 317
PRO A 110
ALA A 116
 None
 1.34A 2ejfB-3errA:
5.3		 2ejfB-3errA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f7w PUTATIVE
FRUCTOSAMINE-3-KINAS
E

(Thermobifida
fusca) 		PF03881
(Fructosamin_kin) 		4 ARG A  58
GLU A  60
PRO A 211
ALA A 213
 None
EDO  A 293 (-3.5A)
None
None
 1.39A 2ejfB-3f7wA:
undetectable		 2ejfB-3f7wA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fip OUTER MEMBRANE USHER
PROTEIN PAPC

(Escherichia
coli) 		PF00577
(Usher) 		4 ARG A 273
ASN A 599
PRO A 289
ALA A 290
 None
 1.29A 2ejfB-3fipA:
undetectable		 2ejfB-3fipA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7s LONG-CHAIN-FATTY-ACI
D--COA LIGASE
(FADD-1)

(Archaeoglobus
fulgidus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ARG A 435
TRP A 333
PRO A 340
ALA A 338
 None
 1.23A 2ejfB-3g7sA:
undetectable		 2ejfB-3g7sA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gri DIHYDROOROTASE

(Staphylococcus
aureus) 		PF01979
(Amidohydro_1) 		4 ARG A 309
GLU A 311
PRO A 320
ALA A 271
 None
 1.18A 2ejfB-3griA:
undetectable		 2ejfB-3griA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gvp ADENOSYLHOMOCYSTEINA
SE 3

(Homo sapiens) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 ARG A 295
GLU A 284
ASN A 265
ALA A 268
 None
 1.38A 2ejfB-3gvpA:
undetectable		 2ejfB-3gvpA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT

(Eubacterium
barkeri) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 GLU A 128
ASN A 149
PRO A 142
ALA A 143
 None
 1.25A 2ejfB-3hrdA:
undetectable		 2ejfB-3hrdA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iv3 TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2

(Streptococcus
mutans) 		PF01791
(DeoC) 		4 ARG A  29
GLU A  50
PRO A  76
ALA A  78
 None
 1.42A 2ejfB-3iv3A:
undetectable		 2ejfB-3iv3A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9o INTRACELLULAR GROWTH
LOCUS PROTEIN B

(Francisella
tularensis) 		PF05943
(VipB) 		4 ARG B 310
GLU B 313
PRO B 446
ALA B 450
 None
 1.41A 2ejfB-3j9oB:
undetectable		 2ejfB-3j9oB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k3q LLAMA AA1 VHH DOMAIN

(Lama glama) 		PF07686
(V-set) 		4 ARG A  68
GLU A  71
PRO A 118
ALA A  64
 None
 1.31A 2ejfB-3k3qA:
undetectable		 2ejfB-3k3qA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Thermus
thermophilus) 		PF01425
(Amidase) 		4 TRP E 284
GLU E 252
PRO E 288
ALA E 290
 None
 1.28A 2ejfB-3kfuE:
undetectable		 2ejfB-3kfuE:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kuq RHO
GTPASE-ACTIVATING
PROTEIN 7

(Homo sapiens) 		PF00620
(RhoGAP) 		4 ARG A1114
ASN A1266
PRO A1231
ALA A1230
 None
 1.02A 2ejfB-3kuqA:
undetectable		 2ejfB-3kuqA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmm UNCHARACTERIZED
PROTEIN

(Corynebacterium
diphtheriae) 		PF04326
(AlbA_2)
PF13749
(HATPase_c_4) 		4 ARG A 352
GLU A 142
ASN A  77
ALA A  73
 None
 1.14A 2ejfB-3lmmA:
undetectable		 2ejfB-3lmmA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwp 6-PHOSPHOGLUCONOLACT
ONASE

(Shewanella
baltica) 		PF01182
(Glucosamine_iso) 		4 TRP A  74
GLU A  72
ASN A 106
ALA A 118
 None
 1.17A 2ejfB-3nwpA:
undetectable		 2ejfB-3nwpA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oep PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0988

(Thermus
thermophilus) 		PF02626
(CT_A_B)
PF02682
(CT_C_D) 		4 ARG A  30
ASN A  18
PRO A  41
ALA A  21
 None
 1.36A 2ejfB-3oepA:
undetectable		 2ejfB-3oepA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqh PUTATIVE
UNCHARACTERIZED
PROTEIN YVMC

(Bacillus
licheniformis) 		PF16715
(CDPS) 		4 ARG A  90
GLU A  92
PRO A  38
ALA A  67
 None
 1.46A 2ejfB-3oqhA:
undetectable		 2ejfB-3oqhA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pm6 PUTATIVE
FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Coccidioides
immitis) 		PF01116
(F_bP_aldolase) 		4 ARG A 209
ASN A 190
PRO A 186
ALA A 187
 IOD  A 308 ( 4.9A)
None
None
None
 1.37A 2ejfB-3pm6A:
undetectable		 2ejfB-3pm6A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqv GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Corynebacterium
glutamicum) 		PF00348
(polyprenyl_synt) 		4 ARG A 184
GLU A  98
PRO A  67
ALA A  70
 None
 1.37A 2ejfB-3qqvA:
undetectable		 2ejfB-3qqvA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r38 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1

(Listeria
monocytogenes) 		PF00275
(EPSP_synthase) 		4 ARG A 282
GLU A 276
PRO A 257
ALA A 255
 None
 1.36A 2ejfB-3r38A:
undetectable		 2ejfB-3r38A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rd7 ACYL-COA
THIOESTERASE

(Mycobacterium
avium) 		PF13622
(4HBT_3) 		4 ARG A 177
GLU A 207
PRO A 162
ALA A 165
 None
 1.01A 2ejfB-3rd7A:
undetectable		 2ejfB-3rd7A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u95 GLYCOSIDE HYDROLASE,
FAMILY 4

(Thermotoga
neapolitana) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		4 GLU A 394
ASN A 215
PRO A 383
ALA A 206
 None
 1.25A 2ejfB-3u95A:
undetectable		 2ejfB-3u95A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vr1 PEPTIDE CHAIN
RELEASE FACTOR 3

(Desulfovibrio
vulgaris) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF16658
(RF3_C) 		4 ARG A 516
GLU A 511
ASN A 506
ALA A 504
 None
 1.47A 2ejfB-3vr1A:
undetectable		 2ejfB-3vr1A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vuv ERYTHROCYTE MEMBRANE
PROTEIN, PUTATIVE

(Plasmodium
falciparum) 		PF05424
(Duffy_binding) 		4 ARG A 314
TRP A 318
GLU A 319
ALA A 238
 None
None
ZN  A 503 (-2.9A)
None
 1.43A 2ejfB-3vuvA:
undetectable		 2ejfB-3vuvA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdg URACIL-DNA
GLYCOSYLASE

(Staphylococcus
aureus) 		PF03167
(UDG) 		4 ARG A  99
GLU A  90
PRO A 195
ALA A 199
 None
 1.21A 2ejfB-3wdgA:
undetectable		 2ejfB-3wdgA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wry TM-1 PROTEIN

(Solanum
lycopersicum) 		PF06792
(UPF0261) 		4 ARG A 288
GLU A 352
ASN A 400
ALA A 357
 None
 1.40A 2ejfB-3wryA:
undetectable		 2ejfB-3wryA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wx5 CELLULASE

(uncultured
bacterium) 		PF01670
(Glyco_hydro_12) 		4 ARG A 247
ASN A  57
PRO A  94
ALA A  92
 None
 1.38A 2ejfB-3wx5A:
undetectable		 2ejfB-3wx5A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bh5 MUREIN HYDROLASE
ACTIVATOR ENVC

(Escherichia
coli) 		PF01551
(Peptidase_M23) 		4 ARG A 303
GLU A 332
PRO A 385
ALA A 335
 None
 1.46A 2ejfB-4bh5A:
undetectable		 2ejfB-4bh5A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dte SERPIN PEPTIDASE
INHIBITOR, CLADE E
(NEXIN, PLASMINOGEN
ACTIVATOR INHIBITOR
TYPE 1), MEMBER 1

(Danio rerio) 		PF00079
(Serpin) 		4 ARG A 154
GLU A 151
PRO A 121
ALA A 124
 None
 1.29A 2ejfB-4dteA:
undetectable		 2ejfB-4dteA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmc RORF2

(Escherichia
coli) 		PF06872
(EspG) 		4 ARG A 387
ASN A 296
PRO A 298
ALA A 299
 None
 1.18A 2ejfB-4fmcA:
undetectable		 2ejfB-4fmcA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3f NF-KAPPA-BETA-INDUCI
NG KINASE

(Mus musculus) 		PF00069
(Pkinase) 		4 ARG A 603
TRP A 598
GLU A 562
ALA A 611
 None
 1.21A 2ejfB-4g3fA:
undetectable		 2ejfB-4g3fA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gd3 HYDROGENASE-1 SMALL
CHAIN

(Escherichia
coli) 		no annotation 4 ARG S 174
ASN S 228
PRO S 147
ALA S 253
 None
SF4  S 402 ( 4.5A)
None
SF4  S 402 ( 4.4A)
 1.32A 2ejfB-4gd3S:
undetectable		 2ejfB-4gd3S:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hrw CYTIDINE AND
DEOXYCYTIDYLATE
DEAMINASE
ZINC-BINDING REGION

(Nitrosomonas
europaea) 		PF00383
(dCMP_cyt_deam_1) 		4 ARG A  72
ASN A  40
PRO A  10
ALA A  43
 None
 1.26A 2ejfB-4hrwA:
undetectable		 2ejfB-4hrwA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwv PECTATE LYASE/AMB
ALLERGEN

(Acidovorax
citrulli) 		PF00544
(Pec_lyase_C) 		4 ARG A  64
GLU A  66
ASN A  74
ALA A  70
 None
 1.48A 2ejfB-4hwvA:
undetectable		 2ejfB-4hwvA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jf8 TRWG COMPONENT OF
TYPE IV SECRETION
SYSTEM

(Bartonella
birtlesii) 		PF04335
(VirB8) 		4 GLU A  95
ASN A 166
PRO A 165
ALA A 171
 None
 1.46A 2ejfB-4jf8A:
undetectable		 2ejfB-4jf8A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jn7 ENOLASE

(Agrobacterium
tumefaciens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ARG A 220
TRP A 227
PRO A 197
ALA A 200
 None
 1.37A 2ejfB-4jn7A:
undetectable		 2ejfB-4jn7A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4js5 EXODEOXYRIBONUCLEASE
I

(Escherichia
coli) 		PF00929
(RNase_T)
PF08411
(Exonuc_X-T_C) 		4 ARG A  87
GLU A  81
PRO A  28
ALA A  29
 None
 1.14A 2ejfB-4js5A:
undetectable		 2ejfB-4js5A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lw8 PUTATIVE EPIMERASE

(Burkholderia
cenocepacia) 		PF01370
(Epimerase) 		4 ARG A 290
GLU A 237
PRO A 234
ALA A 232
 None
EPE  A 400 (-2.9A)
None
None
 1.37A 2ejfB-4lw8A:
undetectable		 2ejfB-4lw8A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oj5 TAILSPIKE PROTEIN

(Escherichia
virus CBA120) 		no annotation 4 ARG A 467
ASN A 531
PRO A 526
ALA A 529
 None
 1.11A 2ejfB-4oj5A:
undetectable		 2ejfB-4oj5A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pev MEMBRANE LIPOPROTEIN
FAMILY PROTEIN

(Aeropyrum
pernix) 		PF02608
(Bmp) 		4 ARG A 171
ASN A 176
PRO A 156
ALA A 155
 None
 1.39A 2ejfB-4pevA:
1.2		 2ejfB-4pevA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdr NEUROPILIN-2

(Homo sapiens) 		PF00754
(F5_F8_type_C) 		4 ARG A 522
GLU A 576
PRO A 483
ALA A 481
 None
 1.32A 2ejfB-4qdrA:
undetectable		 2ejfB-4qdrA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfe ENOYL-COA HYDRATASE

(Mycolicibacterium
smegmatis) 		PF00378
(ECH_1) 		4 GLU A  73
ASN A  75
PRO A  30
ALA A  32
 None
 1.16A 2ejfB-4qfeA:
undetectable		 2ejfB-4qfeA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r04 TOXIN A

(Clostridioides
difficile) 		PF11713
(Peptidase_C80)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
PF12920
(TcdA_TcdB_pore) 		4 ARG A 310
TRP A 311
GLU A 312
ALA A 318
 None
 1.48A 2ejfB-4r04A:
undetectable		 2ejfB-4r04A:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yc6 CYCLIN-DEPENDENT
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 ARG A 180
GLU A 173
PRO A 272
ALA A 273
 None
 1.33A 2ejfB-4yc6A:
undetectable		 2ejfB-4yc6A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a4m HYDROGENASE-1 SMALL
CHAIN

(Escherichia
coli) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 ARG S 174
ASN S 228
PRO S 147
ALA S 253
 None
F3S  S 402 (-4.5A)
None
F3S  S 402 ( 4.3A)
 1.27A 2ejfB-5a4mS:
undetectable		 2ejfB-5a4mS:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cer BD0816

(Bdellovibrio
bacteriovorus) 		PF02113
(Peptidase_S13) 		4 GLU A 292
ASN A  30
PRO A  55
ALA A 352
 None
 1.22A 2ejfB-5cerA:
undetectable		 2ejfB-5cerA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwu NUCLEOPORIN NUP188

(Chaetomium
thermophilum) 		no annotation 4 ARG A1759
GLU A1774
ASN A1708
ALA A1704
 None
 1.28A 2ejfB-5cwuA:
undetectable		 2ejfB-5cwuA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f56 SINGLE-STRANDED-DNA-
SPECIFIC EXONUCLEASE

(Deinococcus
radiodurans) 		PF01368
(DHH)
PF02272
(DHHA1) 		4 ARG A  15
TRP A 665
PRO A  12
ALA A 683
 None
 1.45A 2ejfB-5f56A:
4.3		 2ejfB-5f56A:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fnp IRON-SULFUR CLUSTER
REPAIR PROTEIN YTFE

(Escherichia
coli) 		PF01814
(Hemerythrin)
PF04405
(ScdA_N) 		4 ARG A  82
GLU A 208
ASN A 210
ALA A  30
 None
ZN  A1222 (-2.2A)
None
None
 1.37A 2ejfB-5fnpA:
undetectable		 2ejfB-5fnpA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gin C/D BOX METHYLATION
GUIDE
RIBONUCLEOPROTEIN
COMPLEX ANOP56
SUBUNIT

(Sulfolobus
solfataricus) 		PF01798
(Nop) 		4 ARG A 248
GLU A 255
PRO A 271
ALA A 272
 None
 1.47A 2ejfB-5ginA:
undetectable		 2ejfB-5ginA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjw VOLTAGE-DEPENDENT
CALCIUM CHANNEL
SUBUNIT
ALPHA-2/DELTA-1

(Oryctolagus
cuniculus) 		PF00092
(VWA)
PF08399
(VWA_N)
PF08473
(VGCC_alpha2) 		4 GLU F 414
ASN F 424
PRO F 416
ALA F 420
 None
 1.05A 2ejfB-5gjwF:
undetectable		 2ejfB-5gjwF:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF09334
(tRNA-synt_1g) 		4 ARG A 394
ASN A 276
PRO A 329
ALA A 322
 None
 1.32A 2ejfB-5gl7A:
undetectable		 2ejfB-5gl7A:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hi9 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 2

(Rattus
norvegicus) 		PF00520
(Ion_trans)
PF12796
(Ank_2) 		4 ARG A 317
GLU A 309
ASN A 263
ALA A 257
 None
 1.24A 2ejfB-5hi9A:
undetectable		 2ejfB-5hi9A:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j72 PUTATIVE
N-ACETYLMURAMOYL-L-A
LANINE
AMIDASE,AUTOLYSIN
CWP6

(Clostridioides
difficile) 		PF01520
(Amidase_3)
PF04122
(CW_binding_2) 		4 ARG A  18
GLU A 118
PRO A 140
ALA A 139
 CL  A 706 (-4.1A)
None
None
None
 1.11A 2ejfB-5j72A:
2.7		 2ejfB-5j72A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jip CORTICAL-LYTIC
ENZYME

(Clostridium
perfringens) 		PF01183
(Glyco_hydro_25) 		4 ARG A 144
GLU A 301
ASN A 254
ALA A 234
 None
 1.25A 2ejfB-5jipA:
undetectable		 2ejfB-5jipA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l75 FIG000988: PREDICTED
PERMEASE

(Klebsiella
pneumoniae) 		PF03739
(YjgP_YjgQ) 		4 ARG F 126
GLU F  58
ASN F 116
PRO F  57
 None
 1.26A 2ejfB-5l75F:
undetectable		 2ejfB-5l75F:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lx8 SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 ARG A 145
GLU A 143
PRO A 213
ALA A 217
 None
 1.11A 2ejfB-5lx8A:
undetectable		 2ejfB-5lx8A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzs FERRIC ENTEROBACTIN
RECEPTOR

(Pseudomonas
aeruginosa) 		no annotation 4 ARG A 526
GLU A 508
PRO A 130
ALA A 460
 None
 1.12A 2ejfB-5mzsA:
undetectable		 2ejfB-5mzsA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nzz TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1

(Homo sapiens) 		no annotation 4 ARG A 104
GLU A 269
PRO A 270
ALA A 181
 None
 1.13A 2ejfB-5nzzA:
undetectable		 2ejfB-5nzzA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tv1 BETA-ARRESTIN-2

(Bos taurus) 		no annotation 4 ARG A 323
ASN A 282
PRO A 277
ALA A 255
 None
 1.40A 2ejfB-5tv1A:
undetectable		 2ejfB-5tv1A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u3h HMWP2 NONRIBOSOMAL
PEPTIDE SYNTHETASE

(Yersinia pestis) 		PF00550
(PP-binding) 		4 ARG A  86
ASN A  45
PRO A  25
ALA A  34
 None
 1.48A 2ejfB-5u3hA:
undetectable		 2ejfB-5u3hA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x18 CASEIN KINASE I
HOMOLOG 1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 ARG A 110
GLU A 112
ASN A 120
ALA A 128
 None
GOL  A 402 (-2.8A)
None
None
 1.49A 2ejfB-5x18A:
undetectable		 2ejfB-5x18A:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aun PLA2G6, IPLA2BETA

(Cricetulus
griseus) 		no annotation 4 ARG A 555
GLU A 616
PRO A 551
ALA A 550
 None
 1.38A 2ejfB-6aunA:
undetectable		 2ejfB-6aunA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eu2 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC5

(Saccharomyces
cerevisiae) 		no annotation 4 ARG M 175
GLU M  81
PRO M 172
ALA M 160
 None
 1.39A 2ejfB-6eu2M:
undetectable		 2ejfB-6eu2M:
15.84