SIMILAR PATTERNS OF AMINO ACIDS FOR 2EJF_A_ADNA2001

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ad3 ALDEHYDE
DEHYDROGENASE (CLASS
3)

(Rattus
norvegicus) 		PF00171
(Aldedh) 		4 TRP A  80
GLU A 419
ALA A 129
ALA A 130
 None
 1.00A 2ejfA-1ad3A:
0.3		 2ejfA-1ad3A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b48 PROTEIN (GLUTATHIONE
S-TRANSFERASE)

(Mus musculus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 ARG A  89
GLU A  88
ALA A  96
ALA A 156
 None
 1.07A 2ejfA-1b48A:
undetectable		 2ejfA-1b48A:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bi7 MULTIPLE TUMOR
SUPPRESSOR

(Homo sapiens) 		no annotation 4 ARG B 128
GLU B 119
ALA B 133
ALA B 134
 None
 1.03A 2ejfA-1bi7B:
undetectable		 2ejfA-1bi7B:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3x PENTOSYLTRANSFERASE

(Cellulomonas
sp.) 		PF01048
(PNP_UDP_1) 		4 ARG A 232
GLU A 227
ALA A 123
ALA A 122
 None
 1.02A 2ejfA-1c3xA:
undetectable		 2ejfA-1c3xA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3m 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE

(Escherichia
coli) 		PF01128
(IspD) 		4 ARG A  64
GLU A  39
ALA A  14
ALA A 107
 None
 1.07A 2ejfA-1h3mA:
0.0		 2ejfA-1h3mA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyq CELL DIVISION
INHIBITOR (MIND-1)

(Archaeoglobus
fulgidus) 		PF01656
(CbiA) 		4 ARG A 204
ALA A 221
ASN A  22
ALA A 222
 None
 1.01A 2ejfA-1hyqA:
0.2		 2ejfA-1hyqA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i8q HYALURONATE LYASE

(Streptococcus
agalactiae) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 ARG A 546
GLU A 547
ALA A 554
ALA A 553
 NAG  A1002 (-3.3A)
None
None
None
 0.98A 2ejfA-1i8qA:
0.0		 2ejfA-1i8qA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT

(Klebsiella
pneumoniae) 		PF02286
(Dehydratase_LU) 		4 ARG A 134
GLU A 330
ASN A 298
ALA A 324
 None
 1.01A 2ejfA-1iwpA:
0.0		 2ejfA-1iwpA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1krm ADENOSINE DEAMINASE

(Bos taurus) 		PF00962
(A_deaminase) 		4 GLU A  10
ALA A 327
ASN A 323
ALA A 326
 None
 0.95A 2ejfA-1krmA:
undetectable		 2ejfA-1krmA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mmf GLYCEROL DEHYDRASE
BETA SUBUNIT

(Klebsiella
pneumoniae) 		PF02288
(Dehydratase_MU) 		4 ARG B  70
GLU B  63
ALA B 143
ALA B 140
 None
 0.90A 2ejfA-1mmfB:
undetectable		 2ejfA-1mmfB:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svx ANKYRIN REPEAT
PROTEIN OFF7

(-) 		PF00023
(Ank)
PF12796
(Ank_2) 		4 ARG A  16
ALA A  21
PRO A  50
ALA A  22
 None
 0.81A 2ejfA-1svxA:
undetectable		 2ejfA-1svxA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2x ADP-SPECIFIC
PHOSPHOFRUCTOKINASE

(Pyrococcus
horikoshii) 		PF04587
(ADP_PFK_GK) 		4 GLU A 282
ALA A  33
ASN A  35
ALA A 120
 None
None
SO4  A1003 (-3.8A)
None
 1.05A 2ejfA-1u2xA:
2.9		 2ejfA-1u2xA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uio ADENOSINE DEAMINASE

(Mus musculus) 		PF00962
(A_deaminase) 		4 GLU A  13
ALA A 330
ASN A 326
ALA A 329
 None
 1.00A 2ejfA-1uioA:
undetectable		 2ejfA-1uioA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uxt GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(NADP+)

(Thermoproteus
tenax) 		PF00171
(Aldedh) 		4 ARG A  72
ALA A 187
PRO A 213
ALA A 216
 G1P  A1502 (-3.3A)
None
None
None
 0.95A 2ejfA-1uxtA:
undetectable		 2ejfA-1uxtA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w78 FOLC BIFUNCTIONAL
PROTEIN

(Escherichia
coli) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 ARG A 316
GLU A 311
ALA A 304
ASN A 306
 None
None
ADP  A1425 (-3.1A)
None
 1.04A 2ejfA-1w78A:
undetectable		 2ejfA-1w78A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ykg SULFITE REDUCTASE
[NADPH] FLAVOPROTEIN
ALPHA-COMPONENT

(Escherichia
coli) 		PF00258
(Flavodoxin_1) 		4 ARG A  75
ALA A  97
PRO A 124
ALA A 127
 None
 0.96A 2ejfA-1ykgA:
undetectable		 2ejfA-1ykgA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yks GENOME POLYPROTEIN
[CONTAINS:
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT]

(Yellow fever
virus) 		PF00271
(Helicase_C)
PF07652
(Flavi_DEAD) 		4 ARG A 467
GLU A 425
ALA A 364
PRO A 362
 None
 1.01A 2ejfA-1yksA:
undetectable		 2ejfA-1yksA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ysr SENSOR-TYPE
HISTIDINE KINASE
PRRB

(Mycobacterium
tuberculosis) 		PF02518
(HATPase_c) 		4 ARG A 390
GLU A 395
ALA A 426
ALA A 416
 None
 0.87A 2ejfA-1ysrA:
undetectable		 2ejfA-1ysrA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c20 UDP-GLUCOSE
4-EPIMERASE

(Bacillus
anthracis) 		PF01370
(Epimerase) 		4 ARG A 186
TRP A 320
GLU A 183
ALA A  41
 None
None
ZN  A 601 (-2.9A)
None
 0.97A 2ejfA-2c20A:
undetectable		 2ejfA-2c20A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2com LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1

(Homo sapiens) 		PF04433
(SWIRM) 		4 ARG A  26
GLU A  31
ASN A  54
ALA A  17
 None
 1.08A 2ejfA-2comA:
undetectable		 2ejfA-2comA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfk COLLYBISTIN II

(Rattus
norvegicus) 		PF00169
(PH)
PF00621
(RhoGEF) 		4 ARG A 215
GLU A 126
ALA A 219
ALA A 220
 GOL  A 602 (-3.9A)
None
None
None
 1.08A 2ejfA-2dfkA:
undetectable		 2ejfA-2dfkA:
19.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2djz 235AA LONG
HYPOTHETICAL
BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE

(Pyrococcus
horikoshii) 		PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB) 		7 ARG A  51
TRP A  53
GLU A  54
ALA A 111
ASN A 131
PRO A 137
ALA A 140
 BT5  A1301 (-4.0A)
BT5  A1301 (-3.8A)
None
BT5  A1301 ( 3.8A)
BT5  A1301 (-3.0A)
BT5  A1301 (-4.6A)
BT5  A1301 (-3.4A)
 0.57A 2ejfA-2djzA:
39.1		 2ejfA-2djzA:
99.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ecf DIPEPTIDYL PEPTIDASE
IV

(Stenotrophomonas
maltophilia) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 TRP A 639
ASN A 611
PRO A 527
ALA A 528
 None
 1.04A 2ejfA-2ecfA:
undetectable		 2ejfA-2ecfA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fym ENOLASE

(Escherichia
coli) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 ARG A   9
ALA A 112
ASN A 108
ALA A  36
 None
 1.08A 2ejfA-2fymA:
undetectable		 2ejfA-2fymA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2htm THIAZOLE
BIOSYNTHESIS PROTEIN
THIG

(Thermus
thermophilus) 		PF05690
(ThiG) 		4 GLU A  30
ALA A  35
PRO A 217
ALA A 220
 None
 1.05A 2ejfA-2htmA:
undetectable		 2ejfA-2htmA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jj4 ACETYLGLUTAMATE
KINASE

(Synechococcus
elongatus) 		PF00696
(AA_kinase) 		4 ARG A 139
GLU A 179
ALA A 176
ALA A 177
 None
 0.98A 2ejfA-2jj4A:
undetectable		 2ejfA-2jj4A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ljh DOUBLE-STRANDED
RNA-SPECIFIC EDITASE
ADAR

(Drosophila
melanogaster) 		PF00035
(dsrm) 		4 ARG A  73
GLU A  71
ALA A 121
ALA A 118
 None
 0.99A 2ejfA-2ljhA:
undetectable		 2ejfA-2ljhA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1b AMINOTRANSFERASE,
CLASS I

(Staphylococcus
aureus) 		PF00155
(Aminotran_1_2) 		4 ARG A 295
GLU A 300
ALA A 372
ALA A 373
 None
 0.96A 2ejfA-2o1bA:
undetectable		 2ejfA-2o1bA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p10 MLL9387 PROTEIN

(Mesorhizobium
japonicum) 		PF09370
(PEP_hydrolase) 		4 GLU A 215
ALA A 220
PRO A 172
ALA A 175
 ACT  A 288 (-4.4A)
None
ACT  A 287 (-4.8A)
None
 1.06A 2ejfA-2p10A:
undetectable		 2ejfA-2p10A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r1v DJ-1

(Homo sapiens) 		PF01965
(DJ-1_PfpI) 		4 GLU A  15
ALA A 129
ASN A  76
ALA A 107
 None
 1.01A 2ejfA-2r1vA:
undetectable		 2ejfA-2r1vA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vn8 RETICULON-4-INTERACT
ING PROTEIN 1

(Homo sapiens) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		4 ARG A 388
GLU A 242
ALA A 234
ALA A 249
 NDP  A 600 (-2.9A)
None
None
None
 1.02A 2ejfA-2vn8A:
undetectable		 2ejfA-2vn8A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbn TERMINASE LARGE
SUBUNIT

(Bacillus phage
SPP1) 		PF17288
(Terminase_3C) 		4 ARG A 278
GLU A 293
ALA A 408
ALA A 404
 None
 1.07A 2ejfA-2wbnA:
undetectable		 2ejfA-2wbnA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2q 6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE

(Arthrobacter
sp. KI72) 		PF01425
(Amidase) 		4 GLU A 323
ALA A 171
ASN A 169
ALA A 210
 None
ACA  A 602 ( 3.3A)
None
ACA  A 601 ( 4.9A)
 1.07A 2ejfA-3a2qA:
undetectable		 2ejfA-3a2qA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2r CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I) 		4 ARG A 538
GLU A 539
ALA A 545
ALA A 544
 None
 1.04A 2ejfA-3b2rA:
undetectable		 2ejfA-3b2rA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b40 PROBABLE DIPEPTIDASE

(Pseudomonas
aeruginosa) 		PF01244
(Peptidase_M19) 		4 ARG A 346
GLU A 344
ALA A 351
PRO A 111
 None
 0.94A 2ejfA-3b40A:
undetectable		 2ejfA-3b40A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bf8 ESTERASE YBFF

(Escherichia
coli) 		PF12697
(Abhydrolase_6) 		5 TRP A 188
GLU A 189
ALA A  94
PRO A  65
ALA A  68
 None
 1.25A 2ejfA-3bf8A:
undetectable		 2ejfA-3bf8A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cne PUTATIVE PROTEASE I

(Bacteroides
thetaiotaomicron) 		PF01965
(DJ-1_PfpI) 		4 GLU A  42
ALA A   9
ASN A  11
ALA A  36
 None
 0.99A 2ejfA-3cneA:
undetectable		 2ejfA-3cneA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d2z N-ACETYLMURAMOYL-L-A
LANINE AMIDASE AMID

(Escherichia
coli) 		PF01510
(Amidase_2) 		4 ARG A 235
ALA A 249
PRO A 180
ALA A 253
 None
 1.00A 2ejfA-3d2zA:
undetectable		 2ejfA-3d2zA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3doh ESTERASE

(Thermotoga
maritima) 		PF02230
(Abhydrolase_2) 		4 ARG A 357
ALA A 305
PRO A 308
ALA A 306
 None
 1.03A 2ejfA-3dohA:
undetectable		 2ejfA-3dohA:
20.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3efs BIOTIN
[ACETYL-COA-CARBOXYL
ASE] LIGASE

(Aquifex
aeolicus) 		PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB) 		4 ARG A  43
TRP A  45
ASN A 123
ALA A 137
 ATP  A1001 (-2.9A)
BTN  A2001 ( 3.7A)
ATP  A1001 (-2.8A)
ATP  A1001 (-3.4A)
 0.73A 2ejfA-3efsA:
28.0		 2ejfA-3efsA:
34.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epc PROTEIN VP2

(Enterovirus C) 		PF00073
(Rhv) 		4 GLU 2  55
ALA 2  59
ASN 2  95
ALA 2  60
 None
 1.06A 2ejfA-3epc2:
undetectable		 2ejfA-3epc2:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epf PROTEIN VP2

(Enterovirus C) 		PF00073
(Rhv) 		4 GLU 2  55
ALA 2  59
ASN 2  95
ALA 2  60
 None
 0.99A 2ejfA-3epf2:
undetectable		 2ejfA-3epf2:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f0n MEVALONATE
PYROPHOSPHATE
DECARBOXYLASE

(Mus musculus) 		PF00288
(GHMP_kinases_N) 		4 ARG A 161
ALA A 129
PRO A 379
ALA A  14
 None
 1.08A 2ejfA-3f0nA:
1.9		 2ejfA-3f0nA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fvq FE(3+) IONS IMPORT
ATP-BINDING PROTEIN
FBPC

(Neisseria
gonorrhoeae) 		PF00005
(ABC_tran) 		4 ARG A 228
GLU A 225
ALA A 236
ALA A 235
 None
 1.05A 2ejfA-3fvqA:
undetectable		 2ejfA-3fvqA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fz0 NUCLEOSIDE
HYDROLASE, PUTATIVE

(Trypanosoma
brucei) 		PF01156
(IU_nuc_hydro) 		4 ARG A 311
GLU A 309
ALA A 176
ALA A 175
 None
 1.07A 2ejfA-3fz0A:
undetectable		 2ejfA-3fz0A:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g3l PUTATIVE
UNCHARACTERIZED
MEMBRANE-ASSOCIATED
PROTEIN

(Bacteroides
fragilis) 		PF12985
(DUF3869) 		4 GLU A  60
ALA A  55
ASN A 275
ALA A 122
 None
None
GOL  A  10 (-4.3A)
None
 1.07A 2ejfA-3g3lA:
undetectable		 2ejfA-3g3lA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g4f (+)-DELTA-CADINENE
SYNTHASE ISOZYME XC1

(Gossypium
arboreum) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 ARG A 367
GLU A 369
ALA A 433
ALA A 434
 None
 1.07A 2ejfA-3g4fA:
undetectable		 2ejfA-3g4fA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iom PURINE NUCLEOSIDE
PHOSPHORYLASE

(Mycobacterium
tuberculosis) 		PF01048
(PNP_UDP_1) 		4 ARG A 217
GLU A 212
ALA A 112
ALA A  31
 None
 1.07A 2ejfA-3iomA:
undetectable		 2ejfA-3iomA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3itd 17BETA-HYDROXYSTEROI
D DEHYDROGENASE

(Curvularia
lunata) 		PF13561
(adh_short_C2) 		4 ARG A  28
ALA A  32
PRO A 240
ALA A  33
 None
 1.08A 2ejfA-3itdA:
undetectable		 2ejfA-3itdA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jq1 SUSD SUPERFAMILY
PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 GLU A 143
ALA A 217
PRO A 209
ALA A 213
 None
 1.04A 2ejfA-3jq1A:
undetectable		 2ejfA-3jq1A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mux PUTATIVE
4-HYDROXY-2-OXOGLUTA
RATE ALDOLASE

(Bacillus
anthracis) 		PF07071
(KDGP_aldolase) 		4 ARG A 205
GLU A 172
ALA A 210
ALA A 179
 None
 1.06A 2ejfA-3muxA:
undetectable		 2ejfA-3muxA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwp 6-PHOSPHOGLUCONOLACT
ONASE

(Shewanella
baltica) 		PF01182
(Glucosamine_iso) 		5 TRP A  74
GLU A  72
ALA A 115
ASN A 106
ALA A 118
 None
 1.22A 2ejfA-3nwpA:
undetectable		 2ejfA-3nwpA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pj0 LMO0305 PROTEIN

(Listeria
monocytogenes) 		PF01212
(Beta_elim_lyase) 		4 ARG A 255
GLU A 253
ALA A  30
ASN A  33
 None
 0.99A 2ejfA-3pj0A:
2.5		 2ejfA-3pj0A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qka ENOYL-COA HYDRATASE,
ECHA5

(Mycobacterium
marinum) 		PF00378
(ECH_1) 		4 GLU A  73
ASN A  75
PRO A  30
ALA A  32
 None
 1.08A 2ejfA-3qkaA:
undetectable		 2ejfA-3qkaA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9b CYTOCHROME P450
164A2

(Mycolicibacterium
smegmatis) 		PF00067
(p450) 		4 GLU A 389
ALA A 284
PRO A 388
ALA A 283
 None
 0.90A 2ejfA-3r9bA:
undetectable		 2ejfA-3r9bA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6o POLYSACCHARIDE
DEACETYLASE FAMILY
PROTEIN

(Burkholderia
pseudomallei) 		PF01522
(Polysacc_deac_1) 		4 ALA A  64
ASN A  43
PRO A  50
ALA A  51
 None
 0.91A 2ejfA-3s6oA:
undetectable		 2ejfA-3s6oA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3szb ALDEHYDE
DEHYDROGENASE

(Homo sapiens) 		PF00171
(Aldedh) 		4 TRP A  80
GLU A 419
ALA A 129
ALA A 130
 None
 0.95A 2ejfA-3szbA:
undetectable		 2ejfA-3szbA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr6 O-METHYLTRANSFERASE

(Coxiella
burnetii) 		PF01596
(Methyltransf_3) 		4 ARG A  22
GLU A  23
ALA A  54
ALA A  78
 None
 0.87A 2ejfA-3tr6A:
undetectable		 2ejfA-3tr6A:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0h XYLOSE ISOMERASE
DOMAIN PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF01261
(AP_endonuc_2) 		4 ARG A 268
GLU A 270
ALA A 246
PRO A   3
 None
 0.87A 2ejfA-3u0hA:
undetectable		 2ejfA-3u0hA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ucq AMYLOSUCRASE

(Deinococcus
geothermalis) 		PF00128
(Alpha-amylase) 		4 ARG A 149
GLU A 133
ALA A 141
ALA A 182
 GOL  A 710 (-3.0A)
None
None
None
 1.01A 2ejfA-3ucqA:
undetectable		 2ejfA-3ucqA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufk UNDA

(Shewanella sp.
HRCR_06) 		PF13435
(Cytochrome_C554) 		4 ARG A 471
GLU A 473
ALA A 600
ALA A 611
 NTA  A 923 (-4.0A)
None
None
None
 1.03A 2ejfA-3ufkA:
undetectable		 2ejfA-3ufkA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uj2 ENOLASE 1

(Anaerostipes
caccae) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 ARG A  12
ALA A 115
ASN A 111
ALA A  39
 None
 1.05A 2ejfA-3uj2A:
undetectable		 2ejfA-3uj2A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w3a V-TYPE ATP SYNTHASE
ALPHA CHAIN

(Thermus
thermophilus) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
PF16886
(ATP-synt_ab_Xtn) 		4 ALA A 301
ASN A 290
PRO A 295
ALA A 298
 None
 1.03A 2ejfA-3w3aA:
undetectable		 2ejfA-3w3aA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wh7 BETA-GLUCOSIDASE

(metagenomes) 		PF00232
(Glyco_hydro_1) 		4 ARG A 241
ALA A 300
PRO A 309
ALA A 311
 None
 1.00A 2ejfA-3wh7A:
undetectable		 2ejfA-3wh7A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zou FARNESYL
PYROPHOSPHATE
SYNTHASE

(Pseudomonas
aeruginosa) 		PF00348
(polyprenyl_synt) 		4 ARG A  64
GLU A  56
ALA A  68
ALA A  69
 None
 1.05A 2ejfA-3zouA:
undetectable		 2ejfA-3zouA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4as5 INOSITOL
MONOPHOSPHATASE 1

(Mus musculus) 		PF00459
(Inositol_P) 		4 ARG A 261
GLU A 152
ALA A 210
ALA A 253
 None
 1.02A 2ejfA-4as5A:
undetectable		 2ejfA-4as5A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bj4 AMPDH2

(Pseudomonas
aeruginosa) 		PF01471
(PG_binding_1)
PF01510
(Amidase_2) 		4 ARG A 237
ALA A 251
PRO A 182
ALA A 255
 None
 1.05A 2ejfA-4bj4A:
undetectable		 2ejfA-4bj4A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bqd TISSUE FACTOR
PATHWAY INHIBITOR
(LIPOPROTEIN-ASSOCIA
TED COAGULATION
INHIBITOR) VARIANT

(Homo sapiens) 		PF00014
(Kunitz_BPTI) 		4 ARG A  49
GLU A  52
ALA A  27
ASN A  64
 None
 1.08A 2ejfA-4bqdA:
undetectable		 2ejfA-4bqdA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eud SUCCINYL-COA:ACETATE
COENZYME A
TRANSFERASE

(Acetobacter
aceti) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		4 ARG A 222
GLU A  43
ALA A 219
ALA A  20
 None
 0.87A 2ejfA-4eudA:
undetectable		 2ejfA-4eudA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewt PEPTIDASE,
M20/M25/M40 FAMILY

(Staphylococcus
aureus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 GLU A 282
ALA A 208
ASN A 206
ALA A 211
 None
None
PEG  A 403 (-3.9A)
None
 1.04A 2ejfA-4ewtA:
4.2		 2ejfA-4ewtA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irl MALTOSE-BINDING
PERIPLASMIC PROTEIN,
NOVEL PROTEIN
SIMILAR TO
VERTEBRATE GUANYLATE
BINDING PROTEIN
FAMILY

(Danio rerio;
Escherichia
coli) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		4 GLU A 441
ALA A 339
ASN A 368
ALA A 372
 None
 1.08A 2ejfA-4irlA:
undetectable		 2ejfA-4irlA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jn7 ENOLASE

(Agrobacterium
tumefaciens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ARG A 220
TRP A 227
PRO A 197
ALA A 200
 None
 1.05A 2ejfA-4jn7A:
undetectable		 2ejfA-4jn7A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kp2 HOMOACONITASE LARGE
SUBUNIT

(Methanocaldococcus
jannaschii) 		PF00330
(Aconitase) 		4 TRP A  51
GLU A 146
ALA A  29
ALA A 114
 None
 1.08A 2ejfA-4kp2A:
undetectable		 2ejfA-4kp2A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4llf CAPSID PROTEIN

(Cucumber
necrosis virus) 		PF00729
(Viral_coat) 		4 ARG A 167
ALA A 185
PRO A 181
ALA A 186
 None
 1.01A 2ejfA-4llfA:
undetectable		 2ejfA-4llfA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lpq ERFK/YBIS/YCFS/YNHG
FAMILY PROTEIN

(Xylanimonas
cellulosilytica) 		PF01471
(PG_binding_1)
PF03734
(YkuD) 		4 ARG A 226
ALA A 170
PRO A 197
ALA A 174
 None
 0.92A 2ejfA-4lpqA:
undetectable		 2ejfA-4lpqA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6d TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT

(Desulfovibrio
salexigens) 		PF03480
(DctP) 		4 GLU A 109
ALA A 120
PRO A 234
ALA A 146
 None
 0.89A 2ejfA-4n6dA:
2.1		 2ejfA-4n6dA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzs BETA-KETOTHIOLASE
BKTB

(Cupriavidus
necator) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 ALA A 354
ASN A  56
PRO A  27
ALA A 117
 None
 1.05A 2ejfA-4nzsA:
undetectable		 2ejfA-4nzsA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8o LUCIFERASE-LIKE
ENZYMEAMP-COA-LIGASE

(Zophobas
atratus) 		PF00501
(AMP-binding) 		4 ARG A  54
GLU A 166
ALA A  89
ALA A  59
 None
 0.93A 2ejfA-4w8oA:
undetectable		 2ejfA-4w8oA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp. BTAi1) 		PF13407
(Peripla_BP_4) 		4 ARG A 311
ALA A 157
PRO A 142
ALA A 156
 None
 0.96A 2ejfA-4yhsA:
undetectable		 2ejfA-4yhsA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z7y DIPHOSPHOMEVALONATE
DECARBOXYLASE

(Sulfolobus
solfataricus) 		PF00288
(GHMP_kinases_N) 		4 ARG A 144
ALA A 109
PRO A 319
ALA A   9
 None
 1.07A 2ejfA-4z7yA:
undetectable		 2ejfA-4z7yA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa6 VANADIUM-DEPENDENT
BROMOPEROXIDASE 2

(Ascophyllum
nodosum) 		no annotation 4 TRP A 236
GLU A 546
ALA A 527
ALA A 452
 None
 0.82A 2ejfA-5aa6A:
undetectable		 2ejfA-5aa6A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csa ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00364
(Biotin_lipoyl)
PF08326
(ACC_central) 		4 TRP A 843
ALA A 911
PRO A 877
ALA A 878
 None
 0.95A 2ejfA-5csaA:
undetectable		 2ejfA-5csaA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czc MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE

(Streptomyces
halstedii) 		no annotation 4 ARG A 199
GLU A 197
ALA A 154
PRO A 207
 None
 0.89A 2ejfA-5czcA:
undetectable		 2ejfA-5czcA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7u CYCLOALTERNAN-FORMIN
G ENZYME

(Listeria
monocytogenes) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF16990
(CBM_35) 		4 ARG A 311
GLU A 568
ASN A 588
ALA A 315
 None
 1.04A 2ejfA-5f7uA:
undetectable		 2ejfA-5f7uA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gin 50S RIBOSOMAL
PROTEIN L7AE
C/D BOX METHYLATION
GUIDE
RIBONUCLEOPROTEIN
COMPLEX ANOP56
SUBUNIT

(Sulfolobus
solfataricus) 		PF01248
(Ribosomal_L7Ae)
PF01798
(Nop) 		4 ARG A 350
GLU C  63
ALA C 100
ALA C  57
 None
None
U  H  11 ( 3.7A)
None
 1.04A 2ejfA-5ginA:
undetectable		 2ejfA-5ginA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxd PROTEIN MPAA

(Escherichia
coli) 		PF00246
(Peptidase_M14) 		4 GLU A  18
ALA A  37
PRO A  33
ALA A  34
 None
 1.04A 2ejfA-5hxdA:
undetectable		 2ejfA-5hxdA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1s OXIDOREDUCTASE,
ZINC-BINDING
DEHYDROGENASE FAMILY

(Myxococcus
xanthus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ARG A 193
GLU A 168
ALA A 234
ALA A 256
 None
 1.04A 2ejfA-5k1sA:
undetectable		 2ejfA-5k1sA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5loa MESO-DIAMINOPIMELATE
D-DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF16654
(DAPDH_C) 		4 ARG A  99
ALA A 106
PRO A  77
ALA A  80
 None
 0.95A 2ejfA-5loaA:
undetectable		 2ejfA-5loaA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngd PORTAL PROTEIN

(Thermus virus
P74-26) 		no annotation 4 ARG A 430
ALA A 100
PRO A  88
ALA A  99
 None
 1.04A 2ejfA-5ngdA:
undetectable		 2ejfA-5ngdA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nux CHROMATE REDUCTASE

(Thermus
scotoductus) 		no annotation 4 ARG A  89
ALA A  47
PRO A  97
ALA A  95
 None
 1.08A 2ejfA-5nuxA:
undetectable		 2ejfA-5nuxA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5od2 BIFUNCTIONAL
ADP-SPECIFIC
GLUCOKINASE/PHOSPHOF
RUCTOKINASE

(Methanocaldococcus
jannaschii) 		no annotation 4 GLU A 272
ALA A  22
ASN A  24
ALA A 109
 None
 1.02A 2ejfA-5od2A:
2.2		 2ejfA-5od2A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tc1 MATURATION PROTEIN

(Escherichia
virus MS2) 		PF03863
(Phage_mat-A) 		4 ARG M 168
TRP M 196
ALA M 163
ALA M 175
 None
 1.04A 2ejfA-5tc1M:
undetectable		 2ejfA-5tc1M:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 ARG A 316
ALA A 287
PRO A 344
ALA A 286
 None
 1.07A 2ejfA-5vcxA:
undetectable		 2ejfA-5vcxA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vsj ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE
1

(Streptomyces
coelicolor) 		PF00128
(Alpha-amylase)
PF11896
(DUF3416) 		4 ARG A 497
GLU A 495
PRO A 655
ALA A 656
 None
 1.05A 2ejfA-5vsjA:
undetectable		 2ejfA-5vsjA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wze AMINOPEPTIDASE P

(Pseudomonas
aeruginosa) 		no annotation 4 ARG A 351
GLU A 384
ALA A 313
ALA A 300
 None
MN  A 508 ( 2.3A)
None
None
 1.05A 2ejfA-5wzeA:
undetectable		 2ejfA-5wzeA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yac TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5B

(Pyrococcus
abyssi) 		PF02475
(Met_10) 		4 GLU A 221
ALA A 191
PRO A 234
ALA A 209
 None
 1.03A 2ejfA-5yacA:
undetectable		 2ejfA-5yacA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6an5 ABC TRANSPORTER

(Aquifex
aeolicus) 		no annotation 4 GLU A  89
ALA A 151
ASN A 107
ALA A 155
 None
 1.06A 2ejfA-6an5A:
undetectable		 2ejfA-6an5A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6azp MYELOPEROXIDASE

(Homo sapiens) 		no annotation 4 ARG A 653
ALA A 471
PRO A 659
ALA A 662
 None
 1.02A 2ejfA-6azpA:
2.0		 2ejfA-6azpA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE

(Moorella
thermoacetica) 		no annotation 4 ARG A1087
GLU A1133
ALA A1124
ALA A1095
 None
 0.96A 2ejfA-6cipA:
undetectable		 2ejfA-6cipA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6req PROTEIN
(METHYLMALONYL-COA
MUTASE)

(Propionibacterium
freudenreichii) 		PF01642
(MM_CoA_mutase) 		4 ARG B 139
GLU B 165
ALA B 175
ALA B 176
 None
 1.08A 2ejfA-6reqB:
undetectable		 2ejfA-6reqB:
18.30