SIMILAR PATTERNS OF AMINO ACIDS FOR 2EJ3_A_GBNA2414_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1a3g | BRANCHED-CHAIN AMINOACIDAMINOTRANSFERASE (Escherichiacoli) |
PF01063(Aminotran_4) | 8 | TYR A 95ARG A 97GLY A 196GLU A 197GLY A 256THR A 257ALA A 258ALA A 259 | NoneNonePLP A 413 (-3.9A)NonePLP A 413 ( 3.9A)PLP A 413 (-3.4A)NoneNone | 0.50A | 2ej3A-1a3gA:40.0 | 2ej3A-1a3gA:47.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a4s | BETAINE ALDEHYDEDEHYDROGENASE (Gadus morhua) |
PF00171(Aldedh) | 5 | TYR A 453GLY A 450THR A 451ALA A 429ALA A 449 | None | 1.39A | 2ej3A-1a4sA:undetectable | 2ej3A-1a4sA:23.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c8n | COAT PROTEIN (unidentifiedtobacconecrosis virus) |
PF00729(Viral_coat) | 4 | GLY A 221THR A 222ALA A 223ALA A 224 | None | 0.43A | 2ej3A-1c8nA:undetectable | 2ej3A-1c8nA:23.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e6y | METHYL-COENZYME MREDUCTASE SUBUNITALPHA (Methanosarcinabarkeri) |
PF02249(MCR_alpha)PF02745(MCR_alpha_N) | 4 | GLY A1503THR A1348ALA A1349ALA A1350 | None | 0.47A | 2ej3A-1e6yA:undetectable | 2ej3A-1e6yA:20.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fcd | FLAVOCYTOCHROME CSULFIDEDEHYDROGENASE(FLAVIN-BINDINGSUBUNIT) (Allochromatiumvinosum) |
PF07992(Pyr_redox_2)PF09242(FCSD-flav_bind) | 4 | GLY A 9THR A 16ALA A 17ALA A 18 | FAD A 699 (-3.5A)NoneNoneNone | 0.46A | 2ej3A-1fcdA:undetectable | 2ej3A-1fcdA:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kq0 | METHIONINEAMINOPEPTIDASE 2 (Homo sapiens) |
PF00557(Peptidase_M24) | 4 | GLY A 301GLY A 287THR A 284ALA A 283 | None | 0.57A | 2ej3A-1kq0A:undetectable | 2ej3A-1kq0A:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kt8 | BRANCHED-CHAIN AMINOACIDAMINOTRANSFERASE,MITOCHONDRIAL (Homo sapiens) |
PF01063(Aminotran_4) | 5 | TYR A 141ARG A 143GLY A 312THR A 313ALA A 314 | ILP A 400 (-4.5A)NoneILP A 400 (-3.5A)ILP A 400 (-3.6A)ILP A 400 ( 4.7A) | 0.50A | 2ej3A-1kt8A:30.7 | 2ej3A-1kt8A:27.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mro | METHYL-COENZYME MREDUCTASE (Methanothermobactermarburgensis) |
PF02249(MCR_alpha)PF02745(MCR_alpha_N) | 4 | GLY A 483THR A 335ALA A 336ALA A 337 | NoneNoneMGN A 400 ( 3.6A)None | 0.56A | 2ej3A-1mroA:undetectable | 2ej3A-1mroA:19.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nu5 | CHLOROMUCONATECYCLOISOMERASE (Pseudomonas sp.P51) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | GLY A 45GLY A 304THR A 305ALA A 306ALA A 307 | None | 1.13A | 2ej3A-1nu5A:undetectable | 2ej3A-1nu5A:23.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ovm | INDOLE-3-PYRUVATEDECARBOXYLASE (Enterobactercloacae) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 4 | GLY A 104THR A 105ALA A 106ALA A 107 | None | 0.43A | 2ej3A-1ovmA:undetectable | 2ej3A-1ovmA:20.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qjm | LACTOFERRIN (Equus caballus) |
PF00405(Transferrin) | 4 | TYR A 433THR A 464ALA A 465ALA A 466 | NoneCO3 A 693 (-3.8A)CO3 A 693 (-2.7A)CO3 A 693 (-4.0A) | 0.53A | 2ej3A-1qjmA:undetectable | 2ej3A-1qjmA:20.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u2v | ARP2/3 COMPLEX 16KDASUBUNIT (Bos taurus) |
PF04699(P16-Arc) | 4 | GLY G 49THR G 52ALA G 53ALA G 54 | None | 0.49A | 2ej3A-1u2vG:undetectable | 2ej3A-1u2vG:20.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vjo | ALANINE--GLYOXYLATEAMINOTRANSFERASE (Nostoc sp. PCC7120) |
PF00266(Aminotran_5) | 4 | GLY A 216GLY A 82THR A 83ALA A 84 | NonePLP A 400 (-3.2A)PLP A 400 (-3.5A)None | 0.48A | 2ej3A-1vjoA:undetectable | 2ej3A-1vjoA:21.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zxo | CONSERVEDHYPOTHETICAL PROTEINQ8A1P1 (Bacteroidesthetaiotaomicron) |
no annotation | 4 | GLY A 136GLY A 117THR A 116ALA A 146 | None | 0.54A | 2ej3A-1zxoA:undetectable | 2ej3A-1zxoA:23.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2abj | BRANCHED-CHAIN-AMINO-ACIDAMINOTRANSFERASE,CYTOSOLIC (Homo sapiens) |
PF01063(Aminotran_4) | 5 | TYR A 159ARG A 161GLY A 330THR A 331ALA A 332 | CBC A1401 (-4.3A)CBC A1401 ( 4.8A)CBC A1401 ( 3.4A)PLP A 420 ( 3.6A)CBC A1401 (-3.3A) | 0.33A | 2ej3A-2abjA:31.2 | 2ej3A-2abjA:28.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2acg | PROFILIN II (Acanthamoebacastellanii) |
PF00235(Profilin) | 4 | GLY A 107THR A 108ALA A 109ALA A 110 | None | 0.56A | 2ej3A-2acgA:undetectable | 2ej3A-2acgA:17.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2adu | METHIONINEAMINOPEPTIDASE 2 (Homo sapiens) |
PF00557(Peptidase_M24) | 4 | GLY A 301GLY A 287THR A 284ALA A 283 | None | 0.55A | 2ej3A-2aduA:undetectable | 2ej3A-2aduA:23.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c0l | PEROXISOMALTARGETING SIGNAL 1RECEPTOR (Homo sapiens) |
PF00515(TPR_1)PF13432(TPR_16) | 4 | GLY A 495THR A 512ALA A 513ALA A 514 | None | 0.52A | 2ej3A-2c0lA:undetectable | 2ej3A-2c0lA:24.14 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ej0 | BRANCHED-CHAIN AMINOACIDAMINOTRANSFERASE (Thermusthermophilus) |
PF01063(Aminotran_4) | 8 | TYR A 95ARG A 97GLY A 196GLU A 197GLY A 255THR A 256ALA A 257ALA A 258 | NoneNonePMP A3413 (-3.7A)NonePMP A3413 (-3.5A)PMP A3413 (-3.6A)NoneNone | 0.29A | 2ej3A-2ej0A:49.5 | 2ej3A-2ej0A:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gt1 | LIPOPOLYSACCHARIDEHEPTOSYLTRANSFERASE-1 (Escherichiacoli) |
PF01075(Glyco_transf_9) | 4 | GLY A 12THR A 268ALA A 269ALA A 270 | None | 0.53A | 2ej3A-2gt1A:undetectable | 2ej3A-2gt1A:25.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ibu | ACETYL-COAACETYLTRANSFERASE (Homo sapiens) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 4 | GLY A 152GLY A 68THR A 65ALA A 64 | None | 0.58A | 2ej3A-2ibuA:undetectable | 2ej3A-2ibuA:21.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ntb | PECTINESTERASE A (Dickeyadadantii) |
PF01095(Pectinesterase) | 4 | TYR A 181GLY A 108THR A 109ALA A 110 | None | 0.52A | 2ej3A-2ntbA:undetectable | 2ej3A-2ntbA:22.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2po3 | 4-DEHYDRASE (Streptomycesvenezuelae) |
PF01041(DegT_DnrJ_EryC1) | 4 | GLY A1024GLY A1364THR A1365ALA A1366 | T4K A1500 ( 3.3A)NoneNoneNone | 0.57A | 2ej3A-2po3A:undetectable | 2ej3A-2po3A:25.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ppx | UNCHARACTERIZEDPROTEIN ATU1735 (Agrobacteriumfabrum) |
PF01381(HTH_3) | 4 | TYR A 51THR A 86ALA A 87ALA A 88 | None | 0.51A | 2ej3A-2ppxA:undetectable | 2ej3A-2ppxA:14.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r3s | UNCHARACTERIZEDPROTEIN (Nostocpunctiforme) |
PF00891(Methyltransf_2)PF16864(Dimerisation2) | 4 | GLY A 108THR A 113ALA A 114ALA A 115 | None | 0.57A | 2ej3A-2r3sA:undetectable | 2ej3A-2r3sA:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x8u | SERINEPALMITOYLTRANSFERASE (Sphingomonaswittichii) |
PF00155(Aminotran_1_2) | 4 | GLY A 91THR A 284ALA A 285ALA A 286 | None | 0.47A | 2ej3A-2x8uA:undetectable | 2ej3A-2x8uA:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zy2 | L-ASPARTATE4-CARBOXYLYASE (Pseudomonas sp.ATCC 19121) |
PF00155(Aminotran_1_2) | 4 | GLY A 325THR A 175ALA A 176ALA A 177 | NonePLP A 900 (-3.8A)NoneNone | 0.59A | 2ej3A-2zy2A:undetectable | 2ej3A-2zy2A:21.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ahy | BETA-GLUCOSIDASE (Trichodermareesei) |
PF00232(Glyco_hydro_1) | 5 | TYR A 429GLU A 18GLY A 19THR A 49ALA A 50 | None | 1.49A | 2ej3A-3ahyA:undetectable | 2ej3A-3ahyA:24.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3all | 2-METHYL-3-HYDROXYPYRIDINE-5-CARBOXYLICACID OXYGENASE (Mesorhizobiumjaponicum) |
PF01494(FAD_binding_3) | 4 | GLY A 18THR A 25ALA A 26ALA A 27 | FAD A 380 (-3.3A)NoneNoneNone | 0.55A | 2ej3A-3allA:undetectable | 2ej3A-3allA:24.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cdx | SUCCINYLGLUTAMATEDESUCCINYLASE/ASPARTOACYLASE (Rhodobactersphaeroides) |
PF04952(AstE_AspA) | 5 | ARG A 226GLY A 256THR A 248ALA A 249ALA A 255 | None | 1.40A | 2ej3A-3cdxA:undetectable | 2ej3A-3cdxA:23.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cs3 | SUGAR-BINDINGTRANSCRIPTIONALREGULATOR, LACIFAMILY (Enterococcusfaecalis) |
PF13377(Peripla_BP_3) | 4 | GLY A 207GLY A 214ALA A 216ALA A 217 | None | 0.59A | 2ej3A-3cs3A:undetectable | 2ej3A-3cs3A:23.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3dtg | BRANCHED-CHAIN AMINOACIDAMINOTRANSFERASE (Mycolicibacteriumsmegmatis) |
PF01063(Aminotran_4) | 6 | TYR A 144ARG A 146GLY A 243GLY A 313THR A 314ALA A 315 | NoneOBZ A 371 (-4.2A)PLP A 369 ( 3.8A)PLP A 369 (-3.6A)PLP A 369 (-3.5A)OBZ A 371 ( 4.1A) | 0.30A | 2ej3A-3dtgA:33.0 | 2ej3A-3dtgA:30.37 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3dtg | BRANCHED-CHAIN AMINOACIDAMINOTRANSFERASE (Mycolicibacteriumsmegmatis) |
PF01063(Aminotran_4) | 5 | TYR A 144ARG A 146THR A 314ALA A 315ALA A 316 | NoneOBZ A 371 (-4.2A)PLP A 369 (-3.5A)OBZ A 371 ( 4.1A)None | 0.51A | 2ej3A-3dtgA:33.0 | 2ej3A-3dtgA:30.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f6t | ASPARTATEAMINOTRANSFERASE (Lactobacillusacidophilus) |
PF00155(Aminotran_1_2) | 4 | GLY A 172THR A 173ALA A 174ALA A 175 | LLP A 312 ( 3.5A)LLP A 312 ( 3.6A)NoneNone | 0.51A | 2ej3A-3f6tA:undetectable | 2ej3A-3f6tA:19.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fdd | L-ASPARTATE-BETA-DECARBOXYLASE (Comamonastestosteroni) |
PF00155(Aminotran_1_2) | 4 | GLY A 174THR A 175ALA A 176ALA A 177 | PLP A 534 (-3.4A)PLP A 534 (-3.6A)NoneNone | 0.56A | 2ej3A-3fddA:undetectable | 2ej3A-3fddA:22.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fkd | L-THREONINE-O-3-PHOSPHATE DECARBOXYLASE (Porphyromonasgingivalis) |
PF00155(Aminotran_1_2) | 4 | GLY A 207THR A 77ALA A 78ALA A 79 | None | 0.58A | 2ej3A-3fkdA:undetectable | 2ej3A-3fkdA:21.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fxg | RHAMNONATEDEHYDRATASE (Fusariumgraminearum) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | GLY A 169THR A 173ALA A 174ALA A 175 | None | 0.38A | 2ej3A-3fxgA:undetectable | 2ej3A-3fxgA:21.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gir | AMINOMETHYLTRANSFERASE (Bartonellahenselae) |
PF01571(GCV_T)PF08669(GCV_T_C) | 4 | GLY A 43GLY A 226ALA A 228ALA A 229 | None | 0.55A | 2ej3A-3girA:undetectable | 2ej3A-3girA:24.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gxo | MMCR (Streptomyceslavendulae) |
PF00891(Methyltransf_2) | 4 | GLY A 11THR A 12ALA A 13ALA A 14 | None | 0.48A | 2ej3A-3gxoA:undetectable | 2ej3A-3gxoA:25.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h8l | NADH OXIDASE (Acidianusambivalens) |
PF07992(Pyr_redox_2) | 4 | GLY A 8THR A 15ALA A 16ALA A 17 | FAD A1001 (-3.4A)NoneNoneNone | 0.53A | 2ej3A-3h8lA:undetectable | 2ej3A-3h8lA:22.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hpf | MUCONATECYCLOISOMERASE (Oceanobacillusiheyensis) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | GLY A 38GLY A 303THR A 304ALA A 305ALA A 306 | None | 1.06A | 2ej3A-3hpfA:undetectable | 2ej3A-3hpfA:21.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i4k | MUCONATE LACTONIZINGENZYME (Corynebacteriumglutamicum) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | GLY A 51GLY A 310THR A 311ALA A 312ALA A 313 | GLY A 51 ( 0.0A)GLY A 310 ( 0.0A)THR A 311 ( 0.8A)ALA A 312 ( 0.0A)ALA A 313 ( 0.0A) | 1.17A | 2ej3A-3i4kA:undetectable | 2ej3A-3i4kA:24.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ieg | DNAJ HOMOLOGSUBFAMILY C MEMBER 3 (Mus musculus) |
PF09976(TPR_21)PF13181(TPR_8) | 4 | GLY A 167THR A 171ALA A 172ALA A 173 | None | 0.56A | 2ej3A-3iegA:undetectable | 2ej3A-3iegA:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jac | PIEZO-TYPEMECHANOSENSITIVE IONCHANNEL COMPONENT 1 (Mus musculus) |
PF12166(Piezo_RRas_bdg) | 4 | GLU A2307GLY A2311THR A2312ALA A2313 | None | 0.58A | 2ej3A-3jacA:undetectable | 2ej3A-3jacA:21.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o04 | BETA-KETO-ACYLCARRIER PROTEINSYNTHASE II (Listeriamonocytogenes) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | GLY A 172GLY A 261THR A 405ALA A 404ALA A 262 | None | 0.97A | 2ej3A-3o04A:undetectable | 2ej3A-3o04A:22.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oyt | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE I (Yersinia pestis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | GLY A 172GLY A 262THR A 399ALA A 398ALA A 263 | None | 0.95A | 2ej3A-3oytA:undetectable | 2ej3A-3oytA:23.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oz2 | DIGERANYLGERANYLGLYCEROPHOSPHOLIPIDREDUCTASE (Thermoplasmaacidophilum) |
PF01494(FAD_binding_3) | 4 | GLY A 10THR A 17ALA A 18ALA A 19 | FAD A 501 (-3.4A)NoneNoneNone | 0.49A | 2ej3A-3oz2A:undetectable | 2ej3A-3oz2A:23.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pc3 | CG1753, ISOFORM A (Drosophilamelanogaster) |
PF00291(PALP)PF00571(CBS) | 4 | GLY A 204THR A 205ALA A 206ALA A 207 | None | 0.52A | 2ej3A-3pc3A:undetectable | 2ej3A-3pc3A:21.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s7z | PUTATIVE ASPARTATERACEMASE (Salmonellaenterica) |
PF01177(Asp_Glu_race) | 4 | GLY A 165THR A 168ALA A 169ALA A 170 | None | 0.49A | 2ej3A-3s7zA:undetectable | 2ej3A-3s7zA:23.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t8u | STEROIDDELTA-ISOMERASE (Comamonastestosteroni) |
PF12680(SnoaL_2) | 4 | GLY A 47THR A 48ALA A 49ALA A 50 | None | 0.55A | 2ej3A-3t8uA:undetectable | 2ej3A-3t8uA:18.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u0f | BETA-KETOACYLSYNTHASE (Brucellaabortus) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | GLY A 169GLY A 259THR A 399ALA A 398ALA A 260 | None | 0.96A | 2ej3A-3u0fA:undetectable | 2ej3A-3u0fA:22.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uma | HYPOTHETICALPEROXIREDOXINPROTEIN (Sinorhizobiummeliloti) |
PF08534(Redoxin) | 4 | GLY A 56GLY A 153THR A 150ALA A 149 | None | 0.59A | 2ej3A-3umaA:undetectable | 2ej3A-3umaA:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uqz | DNA PROCESSINGPROTEIN DPRA (Streptococcuspneumoniae) |
PF02481(DNA_processg_A) | 4 | GLY A 113THR A 148ALA A 149ALA A 150 | None | 0.57A | 2ej3A-3uqzA:undetectable | 2ej3A-3uqzA:22.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uzb | BRANCHED-CHAIN-AMINO-ACIDAMINOTRANSFERASE (Deinococcusradiodurans) |
PF01063(Aminotran_4) | 6 | TYR A 143ARG A 145GLY A 303THR A 304ALA A 305ALA A 306 | COI A1517 (-4.8A)NonePLP A 371 (-3.6A)PLP A 371 ( 3.7A)COI A1517 (-3.1A)COI A1517 (-4.1A) | 0.43A | 2ej3A-3uzbA:33.2 | 2ej3A-3uzbA:29.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vrd | FLAVOCYTOCHROME CFLAVIN SUBUNIT (Thermochromatiumtepidum) |
PF07992(Pyr_redox_2)PF09242(FCSD-flav_bind) | 4 | GLY B 9THR B 16ALA B 17ALA B 18 | FAD B 501 (-3.4A)NoneNoneNone | 0.49A | 2ej3A-3vrdB:undetectable | 2ej3A-3vrdB:22.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vuq | TRANSCRIPTIONALREGULATOR (TETR/ACRRFAMILY) (Thermusthermophilus) |
PF00440(TetR_N) | 4 | ARG A 138THR A 155ALA A 156ALA A 157 | None | 0.57A | 2ej3A-3vuqA:undetectable | 2ej3A-3vuqA:22.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bv6 | APOPTOSIS-INDUCINGFACTOR 1,MITOCHONDRIAL (Homo sapiens) |
PF07992(Pyr_redox_2)PF14721(AIF_C) | 4 | GLY A 140THR A 141ALA A 142ALA A 143 | FAD A1449 (-3.4A)FAD A1449 (-4.2A)FAD A1449 (-3.3A)None | 0.45A | 2ej3A-4bv6A:undetectable | 2ej3A-4bv6A:23.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bv6 | APOPTOSIS-INDUCINGFACTOR 1,MITOCHONDRIAL (Homo sapiens) |
PF07992(Pyr_redox_2)PF14721(AIF_C) | 4 | GLY A 261GLY A 140THR A 141ALA A 142 | FAD A1449 (-3.4A)FAD A1449 (-3.4A)FAD A1449 (-4.2A)FAD A1449 (-3.3A) | 0.59A | 2ej3A-4bv6A:undetectable | 2ej3A-4bv6A:23.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cuk | D-LACTATEDEHYDROGENASE (Salmonellaenterica) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C) | 4 | GLY A 153THR A 179ALA A 180ALA A 181 | NAI A1331 (-3.2A)NoneNoneNone | 0.57A | 2ej3A-4cukA:undetectable | 2ej3A-4cukA:24.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dqn | PUTATIVEBRANCHED-CHAIN AMINOACIDAMINOTRANSFERASEILVE (Streptococcusmutans) |
PF01063(Aminotran_4) | 6 | TYR A 124ARG A 126GLY A 284THR A 285ALA A 286ALA A 287 | None | 0.34A | 2ej3A-4dqnA:33.0 | 2ej3A-4dqnA:27.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dzj | GENE 1 PROTEIN (Shigella virusSf6) |
no annotation | 5 | TYR A 60GLY A 28THR A 64ALA A 63ALA A 66 | None | 1.12A | 2ej3A-4dzjA:undetectable | 2ej3A-4dzjA:18.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eyo | EXTRACELLULARLIGAND-BINDINGRECEPTOR (Rhodopseudomonaspalustris) |
PF13458(Peripla_BP_6) | 4 | GLY A 247THR A 224ALA A 225ALA A 226 | HC4 A 401 (-3.4A)NoneNoneNone | 0.58A | 2ej3A-4eyoA:undetectable | 2ej3A-4eyoA:24.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h7u | PYRANOSEDEHYDROGENASE (Leucoagaricusmeleagris) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 4 | GLY A 282GLY A 24THR A 25ALA A 26 | FED A 801 (-3.5A)FED A 801 (-3.3A)FED A 801 (-3.2A)FED A 801 (-3.5A) | 0.54A | 2ej3A-4h7uA:undetectable | 2ej3A-4h7uA:18.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iwh | 3-ISOPROPYLMALATEDEHYDROGENASE (Burkholderiathailandensis) |
PF00180(Iso_dh) | 4 | GLY A 343THR A 344ALA A 345ALA A 346 | None | 0.38A | 2ej3A-4iwhA:undetectable | 2ej3A-4iwhA:24.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jrm | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 2 (Vibrio cholerae) |
no annotation | 5 | TYR D 62GLY D 235GLY D 78ALA D 80ALA D 81 | None | 1.27A | 2ej3A-4jrmD:undetectable | 2ej3A-4jrmD:24.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m0k | ADENINEPHOSPHORIBOSYLTRANSFERASE (Rhodothermusmarinus) |
PF00156(Pribosyltran) | 4 | GLY A 161GLY A 131THR A 132ALA A 133 | NoneAMP A 300 (-3.8A)AMP A 300 (-3.6A)None | 0.59A | 2ej3A-4m0kA:undetectable | 2ej3A-4m0kA:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nfy | D-3-PHOSPHOGLYCERATEDEHYDROGENASE,PUTATIVE (Entamoebahistolytica) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C) | 4 | GLY A 77GLY A 276ALA A 278ALA A 279 | None | 0.57A | 2ej3A-4nfyA:undetectable | 2ej3A-4nfyA:22.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u4e | THIOLASE (Sphaerobacterthermophilus) |
PF02803(Thiolase_C) | 4 | GLY A 376GLY A 259ALA A 261ALA A 262 | None | 0.59A | 2ej3A-4u4eA:undetectable | 2ej3A-4u4eA:22.47 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4whx | BRANCHED-CHAIN-AMINO-ACID TRANSAMINASE (Burkholderiapseudomallei) |
PF01063(Aminotran_4) | 8 | TYR A 98ARG A 100GLY A 198GLU A 199GLY A 257THR A 258ALA A 259ALA A 260 | ALA A 401 (-4.3A)ALA A 401 ( 4.6A)ALA A 401 (-4.0A)NoneLLP A 161 ( 3.4A)LLP A 161 (-3.6A)ALA A 401 (-3.4A)None | 0.26A | 2ej3A-4whxA:42.8 | 2ej3A-4whxA:51.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xgx | FAD:PROTEIN FMNTRANSFERASE (Escherichiacoli) |
PF02424(ApbE) | 4 | GLY A 193GLY A 170ALA A 172ALA A 173 | None | 0.57A | 2ej3A-4xgxA:undetectable | 2ej3A-4xgxA:24.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xox | 3-OXOACYL-ACPSYNTHASE (Vibrio cholerae) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | GLY A 169GLY A 259THR A 395ALA A 394ALA A 260 | None | 0.96A | 2ej3A-4xoxA:undetectable | 2ej3A-4xoxA:25.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xpd | N-TERMINALACETYLTRANSFERASE ACOMPLEX SUBUNIT NAT1 (Saccharomycescerevisiae) |
PF12569(NARP1) | 4 | GLY A 98THR A 115ALA A 116ALA A 117 | None | 0.46A | 2ej3A-4xpdA:undetectable | 2ej3A-4xpdA:16.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xyd | NITRIC-OXIDEREDUCTASE SUBUNIT B (Roseobacterdenitrificans) |
PF00115(COX1) | 4 | GLY A 391THR A 331ALA A 332ALA A 333 | NoneHEM A 504 (-2.7A)HEM A 501 ( 4.9A)None | 0.54A | 2ej3A-4xydA:undetectable | 2ej3A-4xydA:22.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yfa | PROTEIN RELATED TOPENICILLIN ACYLASE (Acidovorax sp.MR-S7) |
PF01804(Penicil_amidase) | 4 | GLY C 7THR C 8ALA C 9ALA C 10 | None | 0.57A | 2ej3A-4yfaC:undetectable | 2ej3A-4yfaC:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yry | DIHYDROPYRIMIDINEDEHYDROGENASESUBUNIT A (Thermotogamaritima) |
PF07992(Pyr_redox_2)PF14691(Fer4_20) | 4 | GLY B 147THR B 154ALA B 155ALA B 156 | FAD B 503 (-2.9A)NoneNoneNone | 0.55A | 2ej3A-4yryB:undetectable | 2ej3A-4yryB:22.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ywo | MERCURIC REDUCTASE (Metallosphaerasedula) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 4 | GLY A 304GLY A 291ALA A 129ALA A 290 | NoneFAD A 501 (-3.3A)NoneNone | 0.57A | 2ej3A-4ywoA:undetectable | 2ej3A-4ywoA:23.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a8r | METHYL-COENZYME MREDUCTASE II SUBUNITALPHA (Methanothermobactermarburgensis) |
PF02249(MCR_alpha)PF02745(MCR_alpha_N) | 4 | GLY A 485THR A 337ALA A 338ALA A 339 | NoneNoneMGN A 402 ( 3.7A)None | 0.58A | 2ej3A-5a8rA:undetectable | 2ej3A-5a8rA:20.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c9i | PROTEIN RELATED TOPENICILLIN ACYLASE (Acidovorax sp.MR-S7) |
PF01804(Penicil_amidase) | 4 | GLY A 209THR A 210ALA A 211ALA A 212 | None | 0.58A | 2ej3A-5c9iA:undetectable | 2ej3A-5c9iA:18.07 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5ce8 | BRANCHED-CHAIN AMINOACIDAMINOTRANSFERASE (Thermoproteusuzoniensis) |
PF01063(Aminotran_4) | 8 | TYR A 91ARG A 93GLY A 187GLU A 188GLY A 247THR A 248ALA A 249ALA A 250 | NoneNonePLP A 301 ( 4.3A)NonePLP A 301 ( 3.7A)PLP A 301 (-3.5A)NoneNone | 0.34A | 2ej3A-5ce8A:40.7 | 2ej3A-5ce8A:43.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cer | BD0816 (Bdellovibriobacteriovorus) |
PF02113(Peptidase_S13) | 4 | GLY A 253THR A 254ALA A 255ALA A 256 | None | 0.55A | 2ej3A-5cerA:undetectable | 2ej3A-5cerA:21.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dis | MALTOSE-BINDINGPERIPLASMICPROTEIN,NUCLEAR PORECOMPLEX PROTEINNUP214 (Escherichiacoli;Homo sapiens) |
PF13416(SBP_bac_8) | 4 | GLY D2015THR D2016ALA D2017ALA D2018 | None | 0.59A | 2ej3A-5disD:undetectable | 2ej3A-5disD:21.88 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5e25 | BRANCHED-CHAINAMINOTRANSFERASE (Geoglobusacetivorans) |
PF01063(Aminotran_4) | 7 | TYR A 89ARG A 91GLY A 188GLY A 247THR A 248ALA A 249ALA A 250 | AKG A 302 (-4.3A)AKG A 302 ( 4.1A)PLP A 301 ( 4.0A)PLP A 301 (-3.4A)PLP A 301 ( 3.7A)AKG A 302 (-3.6A)None | 0.31A | 2ej3A-5e25A:38.8 | 2ej3A-5e25A:41.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5efn | HDAC6 PROTEIN (Danio rerio) |
no annotation | 4 | GLY B 618THR B 588ALA B 589ALA B 590 | None | 0.59A | 2ej3A-5efnB:undetectable | 2ej3A-5efnB:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ex8 | CYTOCHROME P450 (Streptomycestoyocaensis) |
PF00067(p450) | 4 | GLY A 74THR A 75ALA A 76ALA A 77 | None | 0.52A | 2ej3A-5ex8A:undetectable | 2ej3A-5ex8A:21.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fmg | PROTEASOME COMPONENTC8, PUTATIVEPROTEOSOME SUBUNITALPHA TYPE 1,PUTATIVE (Plasmodiumfalciparum) |
PF00227(Proteasome)PF10584(Proteasome_A_N) | 4 | TYR F 13GLY G 85ALA G 135ALA G 136 | None | 0.59A | 2ej3A-5fmgF:undetectable | 2ej3A-5fmgF:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h5v | FLAGELLARHOOK-ASSOCIATEDPROTEIN 2 (Escherichiacoli) |
PF02465(FliD_N)PF07195(FliD_C) | 4 | GLY A 345THR A 363ALA A 364ALA A 365 | None | 0.38A | 2ej3A-5h5vA:undetectable | 2ej3A-5h5vA:22.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ig1 | CAMK/CAMK2 PROTEINKINASE (Salpingoecarosetta) |
PF00069(Pkinase) | 4 | GLY A 282THR A 246ALA A 247ALA A 248 | None | 0.30A | 2ej3A-5ig1A:undetectable | 2ej3A-5ig1A:22.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jbk | BETA-GLUCOSIDASE (Trichodermaharzianum) |
PF00232(Glyco_hydro_1) | 5 | TYR A 429GLU A 19GLY A 20THR A 50ALA A 51 | None | 1.50A | 2ej3A-5jbkA:undetectable | 2ej3A-5jbkA:22.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jd4 | LAE6 (unculturedbacterium) |
PF07859(Abhydrolase_3) | 4 | TYR A 189GLY A 163ALA A 161ALA A 162 | NoneNoneBAM A 407 (-3.1A)BAM A 407 (-3.2A) | 0.59A | 2ej3A-5jd4A:undetectable | 2ej3A-5jd4A:21.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lew | DNA POLYMERASE IIISUBUNIT ALPHA (Mycobacteriumtuberculosis) |
no annotation | 5 | ARG A 667GLY A 383GLY A 790ALA A 788ALA A 789 | None | 1.42A | 2ej3A-5lewA:undetectable | 2ej3A-5lewA:17.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mjk | THIOREDOXINREDUCTASE (Lactococcuslactis) |
PF07992(Pyr_redox_2) | 4 | GLY A 12THR A 19ALA A 20ALA A 21 | FAD A 401 (-3.3A)NoneNoneNone | 0.51A | 2ej3A-5mjkA:undetectable | 2ej3A-5mjkA:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mqz | PUTATIVEBRANCHED-CHAIN-AMINO-ACIDAMINOTRANSFERASE (Archaeoglobusfulgidus) |
no annotation | 7 | TYR A 87ARG A 89GLY A 186GLY A 245THR A 246ALA A 247ALA A 248 | NoneNoneLLP A 150 ( 3.9A)LLP A 150 ( 3.4A)LLP A 150 ( 3.7A)NoneNone | 0.28A | 2ej3A-5mqzA:39.3 | 2ej3A-5mqzA:16.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ncc | FATTY ACIDPHOTODECARBOXYLASE (Chlorellavariabilis) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 4 | GLY A 92THR A 93ALA A 94ALA A 95 | FAD A 701 (-3.3A)FAD A 701 (-3.1A)FAD A 701 (-3.6A)None | 0.32A | 2ej3A-5nccA:undetectable | 2ej3A-5nccA:20.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ttk | AMINE OXIDASE (Pseudomonasputida) |
PF01593(Amino_oxidase) | 4 | GLY A 60THR A 67ALA A 68ALA A 69 | FAD A 501 (-3.1A)NoneNoneNone | 0.53A | 2ej3A-5ttkA:undetectable | 2ej3A-5ttkA:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u3f | BRANCHED-CHAIN-AMINO-ACIDAMINOTRANSFERASE (Mycobacteriumtuberculosis) |
PF01063(Aminotran_4) | 6 | TYR A 144ARG A 146GLY A 243GLY A 313THR A 314ALA A 315 | 7TS A 400 (-4.6A)None7TS A 400 (-3.4A)7TS A 400 (-3.6A)7TS A 400 (-3.6A)None | 0.49A | 2ej3A-5u3fA:33.6 | 2ej3A-5u3fA:29.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u3f | BRANCHED-CHAIN-AMINO-ACIDAMINOTRANSFERASE (Mycobacteriumtuberculosis) |
PF01063(Aminotran_4) | 4 | TYR A 144THR A 314ALA A 315ALA A 316 | 7TS A 400 (-4.6A)7TS A 400 (-3.6A)NoneNone | 0.56A | 2ej3A-5u3fA:33.6 | 2ej3A-5u3fA:29.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uos | METHYLMALONICACIDURIA ANDHOMOCYSTINURIA TYPEC PROTEIN (Homo sapiens) |
PF16690(MMACHC) | 4 | TYR A 31THR A 119ALA A 120ALA A 121 | NoneB12 A 301 ( 2.7A)NoneNone | 0.56A | 2ej3A-5uosA:undetectable | 2ej3A-5uosA:22.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vye | L-THREONINE ALDOLASE (Pseudomonasputida) |
no annotation | 5 | GLY A 213GLY A 64THR A 65ALA A 66ALA A 67 | NonePLR A 401 (-2.8A)PLR A 401 (-3.8A)NoneNone | 0.64A | 2ej3A-5vyeA:undetectable | 2ej3A-5vyeA:13.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cbl | NEAMINE TRANSAMINASENEON (Streptomycesfradiae) |
no annotation | 4 | GLY A 104THR A 105ALA A 106ALA A 107 | DOW A 501 (-3.3A)DOW A 501 (-3.6A)NoneNone | 0.58A | 2ej3A-6cblA:undetectable | 2ej3A-6cblA:15.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cfw | MBH SUBUNITMONOVALENT CATION/H+ANTIPORTER SUBUNIT B (Pyrococcusfuriosus) |
no annotation | 5 | GLY D 75GLY F 47THR F 44ALA F 43ALA F 46 | None | 1.10A | 2ej3A-6cfwD:undetectable | 2ej3A-6cfwD:16.90 |