SIMILAR PATTERNS OF AMINO ACIDS FOR 2EJ3_A_GBNA2414_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1a3g BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE


(Escherichia
coli)
PF01063
(Aminotran_4)
8 TYR A  95
ARG A  97
GLY A 196
GLU A 197
GLY A 256
THR A 257
ALA A 258
ALA A 259
None
None
PLP  A 413 (-3.9A)
None
PLP  A 413 ( 3.9A)
PLP  A 413 (-3.4A)
None
None
0.50A 2ej3A-1a3gA:
40.0
2ej3A-1a3gA:
47.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a4s BETAINE ALDEHYDE
DEHYDROGENASE


(Gadus morhua)
PF00171
(Aldedh)
5 TYR A 453
GLY A 450
THR A 451
ALA A 429
ALA A 449
None
1.39A 2ej3A-1a4sA:
undetectable
2ej3A-1a4sA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c8n COAT PROTEIN

(unidentified
tobacco
necrosis virus)
PF00729
(Viral_coat)
4 GLY A 221
THR A 222
ALA A 223
ALA A 224
None
0.43A 2ej3A-1c8nA:
undetectable
2ej3A-1c8nA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6y METHYL-COENZYME M
REDUCTASE SUBUNIT
ALPHA


(Methanosarcina
barkeri)
PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
4 GLY A1503
THR A1348
ALA A1349
ALA A1350
None
0.47A 2ej3A-1e6yA:
undetectable
2ej3A-1e6yA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)


(Allochromatium
vinosum)
PF07992
(Pyr_redox_2)
PF09242
(FCSD-flav_bind)
4 GLY A   9
THR A  16
ALA A  17
ALA A  18
FAD  A 699 (-3.5A)
None
None
None
0.46A 2ej3A-1fcdA:
undetectable
2ej3A-1fcdA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kq0 METHIONINE
AMINOPEPTIDASE 2


(Homo sapiens)
PF00557
(Peptidase_M24)
4 GLY A 301
GLY A 287
THR A 284
ALA A 283
None
0.57A 2ej3A-1kq0A:
undetectable
2ej3A-1kq0A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL


(Homo sapiens)
PF01063
(Aminotran_4)
5 TYR A 141
ARG A 143
GLY A 312
THR A 313
ALA A 314
ILP  A 400 (-4.5A)
None
ILP  A 400 (-3.5A)
ILP  A 400 (-3.6A)
ILP  A 400 ( 4.7A)
0.50A 2ej3A-1kt8A:
30.7
2ej3A-1kt8A:
27.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mro METHYL-COENZYME M
REDUCTASE


(Methanothermobacter
marburgensis)
PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
4 GLY A 483
THR A 335
ALA A 336
ALA A 337
None
None
MGN  A 400 ( 3.6A)
None
0.56A 2ej3A-1mroA:
undetectable
2ej3A-1mroA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nu5 CHLOROMUCONATE
CYCLOISOMERASE


(Pseudomonas sp.
P51)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 GLY A  45
GLY A 304
THR A 305
ALA A 306
ALA A 307
None
1.13A 2ej3A-1nu5A:
undetectable
2ej3A-1nu5A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ovm INDOLE-3-PYRUVATE
DECARBOXYLASE


(Enterobacter
cloacae)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
4 GLY A 104
THR A 105
ALA A 106
ALA A 107
None
0.43A 2ej3A-1ovmA:
undetectable
2ej3A-1ovmA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qjm LACTOFERRIN

(Equus caballus)
PF00405
(Transferrin)
4 TYR A 433
THR A 464
ALA A 465
ALA A 466
None
CO3  A 693 (-3.8A)
CO3  A 693 (-2.7A)
CO3  A 693 (-4.0A)
0.53A 2ej3A-1qjmA:
undetectable
2ej3A-1qjmA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2v ARP2/3 COMPLEX 16KDA
SUBUNIT


(Bos taurus)
PF04699
(P16-Arc)
4 GLY G  49
THR G  52
ALA G  53
ALA G  54
None
0.49A 2ej3A-1u2vG:
undetectable
2ej3A-1u2vG:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjo ALANINE--GLYOXYLATE
AMINOTRANSFERASE


(Nostoc sp. PCC
7120)
PF00266
(Aminotran_5)
4 GLY A 216
GLY A  82
THR A  83
ALA A  84
None
PLP  A 400 (-3.2A)
PLP  A 400 (-3.5A)
None
0.48A 2ej3A-1vjoA:
undetectable
2ej3A-1vjoA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zxo CONSERVED
HYPOTHETICAL PROTEIN
Q8A1P1


(Bacteroides
thetaiotaomicron)
no annotation 4 GLY A 136
GLY A 117
THR A 116
ALA A 146
None
0.54A 2ej3A-1zxoA:
undetectable
2ej3A-1zxoA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC


(Homo sapiens)
PF01063
(Aminotran_4)
5 TYR A 159
ARG A 161
GLY A 330
THR A 331
ALA A 332
CBC  A1401 (-4.3A)
CBC  A1401 ( 4.8A)
CBC  A1401 ( 3.4A)
PLP  A 420 ( 3.6A)
CBC  A1401 (-3.3A)
0.33A 2ej3A-2abjA:
31.2
2ej3A-2abjA:
28.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2acg PROFILIN II

(Acanthamoeba
castellanii)
PF00235
(Profilin)
4 GLY A 107
THR A 108
ALA A 109
ALA A 110
None
0.56A 2ej3A-2acgA:
undetectable
2ej3A-2acgA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2adu METHIONINE
AMINOPEPTIDASE 2


(Homo sapiens)
PF00557
(Peptidase_M24)
4 GLY A 301
GLY A 287
THR A 284
ALA A 283
None
0.55A 2ej3A-2aduA:
undetectable
2ej3A-2aduA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0l PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR


(Homo sapiens)
PF00515
(TPR_1)
PF13432
(TPR_16)
4 GLY A 495
THR A 512
ALA A 513
ALA A 514
None
0.52A 2ej3A-2c0lA:
undetectable
2ej3A-2c0lA:
24.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ej0 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE


(Thermus
thermophilus)
PF01063
(Aminotran_4)
8 TYR A  95
ARG A  97
GLY A 196
GLU A 197
GLY A 255
THR A 256
ALA A 257
ALA A 258
None
None
PMP  A3413 (-3.7A)
None
PMP  A3413 (-3.5A)
PMP  A3413 (-3.6A)
None
None
0.29A 2ej3A-2ej0A:
49.5
2ej3A-2ej0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gt1 LIPOPOLYSACCHARIDE
HEPTOSYLTRANSFERASE-
1


(Escherichia
coli)
PF01075
(Glyco_transf_9)
4 GLY A  12
THR A 268
ALA A 269
ALA A 270
None
0.53A 2ej3A-2gt1A:
undetectable
2ej3A-2gt1A:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibu ACETYL-COA
ACETYLTRANSFERASE


(Homo sapiens)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
4 GLY A 152
GLY A  68
THR A  65
ALA A  64
None
0.58A 2ej3A-2ibuA:
undetectable
2ej3A-2ibuA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ntb PECTINESTERASE A

(Dickeya
dadantii)
PF01095
(Pectinesterase)
4 TYR A 181
GLY A 108
THR A 109
ALA A 110
None
0.52A 2ej3A-2ntbA:
undetectable
2ej3A-2ntbA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po3 4-DEHYDRASE

(Streptomyces
venezuelae)
PF01041
(DegT_DnrJ_EryC1)
4 GLY A1024
GLY A1364
THR A1365
ALA A1366
T4K  A1500 ( 3.3A)
None
None
None
0.57A 2ej3A-2po3A:
undetectable
2ej3A-2po3A:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppx UNCHARACTERIZED
PROTEIN ATU1735


(Agrobacterium
fabrum)
PF01381
(HTH_3)
4 TYR A  51
THR A  86
ALA A  87
ALA A  88
None
0.51A 2ej3A-2ppxA:
undetectable
2ej3A-2ppxA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3s UNCHARACTERIZED
PROTEIN


(Nostoc
punctiforme)
PF00891
(Methyltransf_2)
PF16864
(Dimerisation2)
4 GLY A 108
THR A 113
ALA A 114
ALA A 115
None
0.57A 2ej3A-2r3sA:
undetectable
2ej3A-2r3sA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x8u SERINE
PALMITOYLTRANSFERASE


(Sphingomonas
wittichii)
PF00155
(Aminotran_1_2)
4 GLY A  91
THR A 284
ALA A 285
ALA A 286
None
0.47A 2ej3A-2x8uA:
undetectable
2ej3A-2x8uA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zy2 L-ASPARTATE
4-CARBOXYLYASE


(Pseudomonas sp.
ATCC 19121)
PF00155
(Aminotran_1_2)
4 GLY A 325
THR A 175
ALA A 176
ALA A 177
None
PLP  A 900 (-3.8A)
None
None
0.59A 2ej3A-2zy2A:
undetectable
2ej3A-2zy2A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahy BETA-GLUCOSIDASE

(Trichoderma
reesei)
PF00232
(Glyco_hydro_1)
5 TYR A 429
GLU A  18
GLY A  19
THR A  49
ALA A  50
None
1.49A 2ej3A-3ahyA:
undetectable
2ej3A-3ahyA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3all 2-METHYL-3-HYDROXYPY
RIDINE-5-CARBOXYLIC
ACID OXYGENASE


(Mesorhizobium
japonicum)
PF01494
(FAD_binding_3)
4 GLY A  18
THR A  25
ALA A  26
ALA A  27
FAD  A 380 (-3.3A)
None
None
None
0.55A 2ej3A-3allA:
undetectable
2ej3A-3allA:
24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cdx SUCCINYLGLUTAMATEDES
UCCINYLASE/ASPARTOAC
YLASE


(Rhodobacter
sphaeroides)
PF04952
(AstE_AspA)
5 ARG A 226
GLY A 256
THR A 248
ALA A 249
ALA A 255
None
1.40A 2ej3A-3cdxA:
undetectable
2ej3A-3cdxA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cs3 SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY


(Enterococcus
faecalis)
PF13377
(Peripla_BP_3)
4 GLY A 207
GLY A 214
ALA A 216
ALA A 217
None
0.59A 2ej3A-3cs3A:
undetectable
2ej3A-3cs3A:
23.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dtg BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE


(Mycolicibacterium
smegmatis)
PF01063
(Aminotran_4)
6 TYR A 144
ARG A 146
GLY A 243
GLY A 313
THR A 314
ALA A 315
None
OBZ  A 371 (-4.2A)
PLP  A 369 ( 3.8A)
PLP  A 369 (-3.6A)
PLP  A 369 (-3.5A)
OBZ  A 371 ( 4.1A)
0.30A 2ej3A-3dtgA:
33.0
2ej3A-3dtgA:
30.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dtg BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE


(Mycolicibacterium
smegmatis)
PF01063
(Aminotran_4)
5 TYR A 144
ARG A 146
THR A 314
ALA A 315
ALA A 316
None
OBZ  A 371 (-4.2A)
PLP  A 369 (-3.5A)
OBZ  A 371 ( 4.1A)
None
0.51A 2ej3A-3dtgA:
33.0
2ej3A-3dtgA:
30.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f6t ASPARTATE
AMINOTRANSFERASE


(Lactobacillus
acidophilus)
PF00155
(Aminotran_1_2)
4 GLY A 172
THR A 173
ALA A 174
ALA A 175
LLP  A 312 ( 3.5A)
LLP  A 312 ( 3.6A)
None
None
0.51A 2ej3A-3f6tA:
undetectable
2ej3A-3f6tA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE


(Comamonas
testosteroni)
PF00155
(Aminotran_1_2)
4 GLY A 174
THR A 175
ALA A 176
ALA A 177
PLP  A 534 (-3.4A)
PLP  A 534 (-3.6A)
None
None
0.56A 2ej3A-3fddA:
undetectable
2ej3A-3fddA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fkd L-THREONINE-O-3-PHOS
PHATE DECARBOXYLASE


(Porphyromonas
gingivalis)
PF00155
(Aminotran_1_2)
4 GLY A 207
THR A  77
ALA A  78
ALA A  79
None
0.58A 2ej3A-3fkdA:
undetectable
2ej3A-3fkdA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxg RHAMNONATE
DEHYDRATASE


(Fusarium
graminearum)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 GLY A 169
THR A 173
ALA A 174
ALA A 175
None
0.38A 2ej3A-3fxgA:
undetectable
2ej3A-3fxgA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gir AMINOMETHYLTRANSFERA
SE


(Bartonella
henselae)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
4 GLY A  43
GLY A 226
ALA A 228
ALA A 229
None
0.55A 2ej3A-3girA:
undetectable
2ej3A-3girA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gxo MMCR

(Streptomyces
lavendulae)
PF00891
(Methyltransf_2)
4 GLY A  11
THR A  12
ALA A  13
ALA A  14
None
0.48A 2ej3A-3gxoA:
undetectable
2ej3A-3gxoA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h8l NADH OXIDASE

(Acidianus
ambivalens)
PF07992
(Pyr_redox_2)
4 GLY A   8
THR A  15
ALA A  16
ALA A  17
FAD  A1001 (-3.4A)
None
None
None
0.53A 2ej3A-3h8lA:
undetectable
2ej3A-3h8lA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpf MUCONATE
CYCLOISOMERASE


(Oceanobacillus
iheyensis)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 GLY A  38
GLY A 303
THR A 304
ALA A 305
ALA A 306
None
1.06A 2ej3A-3hpfA:
undetectable
2ej3A-3hpfA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4k MUCONATE LACTONIZING
ENZYME


(Corynebacterium
glutamicum)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 GLY A  51
GLY A 310
THR A 311
ALA A 312
ALA A 313
GLY  A  51 ( 0.0A)
GLY  A 310 ( 0.0A)
THR  A 311 ( 0.8A)
ALA  A 312 ( 0.0A)
ALA  A 313 ( 0.0A)
1.17A 2ej3A-3i4kA:
undetectable
2ej3A-3i4kA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ieg DNAJ HOMOLOG
SUBFAMILY C MEMBER 3


(Mus musculus)
PF09976
(TPR_21)
PF13181
(TPR_8)
4 GLY A 167
THR A 171
ALA A 172
ALA A 173
None
0.56A 2ej3A-3iegA:
undetectable
2ej3A-3iegA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jac PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1


(Mus musculus)
PF12166
(Piezo_RRas_bdg)
4 GLU A2307
GLY A2311
THR A2312
ALA A2313
None
0.58A 2ej3A-3jacA:
undetectable
2ej3A-3jacA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o04 BETA-KETO-ACYL
CARRIER PROTEIN
SYNTHASE II


(Listeria
monocytogenes)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
5 GLY A 172
GLY A 261
THR A 405
ALA A 404
ALA A 262
None
0.97A 2ej3A-3o04A:
undetectable
2ej3A-3o04A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oyt 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE I


(Yersinia pestis)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
5 GLY A 172
GLY A 262
THR A 399
ALA A 398
ALA A 263
None
0.95A 2ej3A-3oytA:
undetectable
2ej3A-3oytA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oz2 DIGERANYLGERANYLGLYC
EROPHOSPHOLIPID
REDUCTASE


(Thermoplasma
acidophilum)
PF01494
(FAD_binding_3)
4 GLY A  10
THR A  17
ALA A  18
ALA A  19
FAD  A 501 (-3.4A)
None
None
None
0.49A 2ej3A-3oz2A:
undetectable
2ej3A-3oz2A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pc3 CG1753, ISOFORM A

(Drosophila
melanogaster)
PF00291
(PALP)
PF00571
(CBS)
4 GLY A 204
THR A 205
ALA A 206
ALA A 207
None
0.52A 2ej3A-3pc3A:
undetectable
2ej3A-3pc3A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s7z PUTATIVE ASPARTATE
RACEMASE


(Salmonella
enterica)
PF01177
(Asp_Glu_race)
4 GLY A 165
THR A 168
ALA A 169
ALA A 170
None
0.49A 2ej3A-3s7zA:
undetectable
2ej3A-3s7zA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8u STEROID
DELTA-ISOMERASE


(Comamonas
testosteroni)
PF12680
(SnoaL_2)
4 GLY A  47
THR A  48
ALA A  49
ALA A  50
None
0.55A 2ej3A-3t8uA:
undetectable
2ej3A-3t8uA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0f BETA-KETOACYL
SYNTHASE


(Brucella
abortus)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
5 GLY A 169
GLY A 259
THR A 399
ALA A 398
ALA A 260
None
0.96A 2ej3A-3u0fA:
undetectable
2ej3A-3u0fA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uma HYPOTHETICAL
PEROXIREDOXIN
PROTEIN


(Sinorhizobium
meliloti)
PF08534
(Redoxin)
4 GLY A  56
GLY A 153
THR A 150
ALA A 149
None
0.59A 2ej3A-3umaA:
undetectable
2ej3A-3umaA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uqz DNA PROCESSING
PROTEIN DPRA


(Streptococcus
pneumoniae)
PF02481
(DNA_processg_A)
4 GLY A 113
THR A 148
ALA A 149
ALA A 150
None
0.57A 2ej3A-3uqzA:
undetectable
2ej3A-3uqzA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uzb BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE


(Deinococcus
radiodurans)
PF01063
(Aminotran_4)
6 TYR A 143
ARG A 145
GLY A 303
THR A 304
ALA A 305
ALA A 306
COI  A1517 (-4.8A)
None
PLP  A 371 (-3.6A)
PLP  A 371 ( 3.7A)
COI  A1517 (-3.1A)
COI  A1517 (-4.1A)
0.43A 2ej3A-3uzbA:
33.2
2ej3A-3uzbA:
29.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrd FLAVOCYTOCHROME C
FLAVIN SUBUNIT


(Thermochromatium
tepidum)
PF07992
(Pyr_redox_2)
PF09242
(FCSD-flav_bind)
4 GLY B   9
THR B  16
ALA B  17
ALA B  18
FAD  B 501 (-3.4A)
None
None
None
0.49A 2ej3A-3vrdB:
undetectable
2ej3A-3vrdB:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vuq TRANSCRIPTIONAL
REGULATOR (TETR/ACRR
FAMILY)


(Thermus
thermophilus)
PF00440
(TetR_N)
4 ARG A 138
THR A 155
ALA A 156
ALA A 157
None
0.57A 2ej3A-3vuqA:
undetectable
2ej3A-3vuqA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL


(Homo sapiens)
PF07992
(Pyr_redox_2)
PF14721
(AIF_C)
4 GLY A 140
THR A 141
ALA A 142
ALA A 143
FAD  A1449 (-3.4A)
FAD  A1449 (-4.2A)
FAD  A1449 (-3.3A)
None
0.45A 2ej3A-4bv6A:
undetectable
2ej3A-4bv6A:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bv6 APOPTOSIS-INDUCING
FACTOR 1,
MITOCHONDRIAL


(Homo sapiens)
PF07992
(Pyr_redox_2)
PF14721
(AIF_C)
4 GLY A 261
GLY A 140
THR A 141
ALA A 142
FAD  A1449 (-3.4A)
FAD  A1449 (-3.4A)
FAD  A1449 (-4.2A)
FAD  A1449 (-3.3A)
0.59A 2ej3A-4bv6A:
undetectable
2ej3A-4bv6A:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cuk D-LACTATE
DEHYDROGENASE


(Salmonella
enterica)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
4 GLY A 153
THR A 179
ALA A 180
ALA A 181
NAI  A1331 (-3.2A)
None
None
None
0.57A 2ej3A-4cukA:
undetectable
2ej3A-4cukA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dqn PUTATIVE
BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
ILVE


(Streptococcus
mutans)
PF01063
(Aminotran_4)
6 TYR A 124
ARG A 126
GLY A 284
THR A 285
ALA A 286
ALA A 287
None
0.34A 2ej3A-4dqnA:
33.0
2ej3A-4dqnA:
27.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dzj GENE 1 PROTEIN

(Shigella virus
Sf6)
no annotation 5 TYR A  60
GLY A  28
THR A  64
ALA A  63
ALA A  66
None
1.12A 2ej3A-4dzjA:
undetectable
2ej3A-4dzjA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eyo EXTRACELLULAR
LIGAND-BINDING
RECEPTOR


(Rhodopseudomonas
palustris)
PF13458
(Peripla_BP_6)
4 GLY A 247
THR A 224
ALA A 225
ALA A 226
HC4  A 401 (-3.4A)
None
None
None
0.58A 2ej3A-4eyoA:
undetectable
2ej3A-4eyoA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h7u PYRANOSE
DEHYDROGENASE


(Leucoagaricus
meleagris)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
4 GLY A 282
GLY A  24
THR A  25
ALA A  26
FED  A 801 (-3.5A)
FED  A 801 (-3.3A)
FED  A 801 (-3.2A)
FED  A 801 (-3.5A)
0.54A 2ej3A-4h7uA:
undetectable
2ej3A-4h7uA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iwh 3-ISOPROPYLMALATE
DEHYDROGENASE


(Burkholderia
thailandensis)
PF00180
(Iso_dh)
4 GLY A 343
THR A 344
ALA A 345
ALA A 346
None
0.38A 2ej3A-4iwhA:
undetectable
2ej3A-4iwhA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2


(Vibrio cholerae)
no annotation 5 TYR D  62
GLY D 235
GLY D  78
ALA D  80
ALA D  81
None
1.27A 2ej3A-4jrmD:
undetectable
2ej3A-4jrmD:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0k ADENINE
PHOSPHORIBOSYLTRANSF
ERASE


(Rhodothermus
marinus)
PF00156
(Pribosyltran)
4 GLY A 161
GLY A 131
THR A 132
ALA A 133
None
AMP  A 300 (-3.8A)
AMP  A 300 (-3.6A)
None
0.59A 2ej3A-4m0kA:
undetectable
2ej3A-4m0kA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfy D-3-PHOSPHOGLYCERATE
DEHYDROGENASE,
PUTATIVE


(Entamoeba
histolytica)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
4 GLY A  77
GLY A 276
ALA A 278
ALA A 279
None
0.57A 2ej3A-4nfyA:
undetectable
2ej3A-4nfyA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u4e THIOLASE

(Sphaerobacter
thermophilus)
PF02803
(Thiolase_C)
4 GLY A 376
GLY A 259
ALA A 261
ALA A 262
None
0.59A 2ej3A-4u4eA:
undetectable
2ej3A-4u4eA:
22.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4whx BRANCHED-CHAIN-AMINO
-ACID TRANSAMINASE


(Burkholderia
pseudomallei)
PF01063
(Aminotran_4)
8 TYR A  98
ARG A 100
GLY A 198
GLU A 199
GLY A 257
THR A 258
ALA A 259
ALA A 260
ALA  A 401 (-4.3A)
ALA  A 401 ( 4.6A)
ALA  A 401 (-4.0A)
None
LLP  A 161 ( 3.4A)
LLP  A 161 (-3.6A)
ALA  A 401 (-3.4A)
None
0.26A 2ej3A-4whxA:
42.8
2ej3A-4whxA:
51.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgx FAD:PROTEIN FMN
TRANSFERASE


(Escherichia
coli)
PF02424
(ApbE)
4 GLY A 193
GLY A 170
ALA A 172
ALA A 173
None
0.57A 2ej3A-4xgxA:
undetectable
2ej3A-4xgxA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xox 3-OXOACYL-ACP
SYNTHASE


(Vibrio cholerae)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
5 GLY A 169
GLY A 259
THR A 395
ALA A 394
ALA A 260
None
0.96A 2ej3A-4xoxA:
undetectable
2ej3A-4xoxA:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xpd N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1


(Saccharomyces
cerevisiae)
PF12569
(NARP1)
4 GLY A  98
THR A 115
ALA A 116
ALA A 117
None
0.46A 2ej3A-4xpdA:
undetectable
2ej3A-4xpdA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B


(Roseobacter
denitrificans)
PF00115
(COX1)
4 GLY A 391
THR A 331
ALA A 332
ALA A 333
None
HEM  A 504 (-2.7A)
HEM  A 501 ( 4.9A)
None
0.54A 2ej3A-4xydA:
undetectable
2ej3A-4xydA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE


(Acidovorax sp.
MR-S7)
PF01804
(Penicil_amidase)
4 GLY C   7
THR C   8
ALA C   9
ALA C  10
None
0.57A 2ej3A-4yfaC:
undetectable
2ej3A-4yfaC:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yry DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A


(Thermotoga
maritima)
PF07992
(Pyr_redox_2)
PF14691
(Fer4_20)
4 GLY B 147
THR B 154
ALA B 155
ALA B 156
FAD  B 503 (-2.9A)
None
None
None
0.55A 2ej3A-4yryB:
undetectable
2ej3A-4yryB:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywo MERCURIC REDUCTASE

(Metallosphaera
sedula)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
4 GLY A 304
GLY A 291
ALA A 129
ALA A 290
None
FAD  A 501 (-3.3A)
None
None
0.57A 2ej3A-4ywoA:
undetectable
2ej3A-4ywoA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
ALPHA


(Methanothermobacter
marburgensis)
PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N)
4 GLY A 485
THR A 337
ALA A 338
ALA A 339
None
None
MGN  A 402 ( 3.7A)
None
0.58A 2ej3A-5a8rA:
undetectable
2ej3A-5a8rA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c9i PROTEIN RELATED TO
PENICILLIN ACYLASE


(Acidovorax sp.
MR-S7)
PF01804
(Penicil_amidase)
4 GLY A 209
THR A 210
ALA A 211
ALA A 212
None
0.58A 2ej3A-5c9iA:
undetectable
2ej3A-5c9iA:
18.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ce8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE


(Thermoproteus
uzoniensis)
PF01063
(Aminotran_4)
8 TYR A  91
ARG A  93
GLY A 187
GLU A 188
GLY A 247
THR A 248
ALA A 249
ALA A 250
None
None
PLP  A 301 ( 4.3A)
None
PLP  A 301 ( 3.7A)
PLP  A 301 (-3.5A)
None
None
0.34A 2ej3A-5ce8A:
40.7
2ej3A-5ce8A:
43.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cer BD0816

(Bdellovibrio
bacteriovorus)
PF02113
(Peptidase_S13)
4 GLY A 253
THR A 254
ALA A 255
ALA A 256
None
0.55A 2ej3A-5cerA:
undetectable
2ej3A-5cerA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dis MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR PORE
COMPLEX PROTEIN
NUP214


(Escherichia
coli;
Homo sapiens)
PF13416
(SBP_bac_8)
4 GLY D2015
THR D2016
ALA D2017
ALA D2018
None
0.59A 2ej3A-5disD:
undetectable
2ej3A-5disD:
21.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e25 BRANCHED-CHAIN
AMINOTRANSFERASE


(Geoglobus
acetivorans)
PF01063
(Aminotran_4)
7 TYR A  89
ARG A  91
GLY A 188
GLY A 247
THR A 248
ALA A 249
ALA A 250
AKG  A 302 (-4.3A)
AKG  A 302 ( 4.1A)
PLP  A 301 ( 4.0A)
PLP  A 301 (-3.4A)
PLP  A 301 ( 3.7A)
AKG  A 302 (-3.6A)
None
0.31A 2ej3A-5e25A:
38.8
2ej3A-5e25A:
41.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5efn HDAC6 PROTEIN

(Danio rerio)
no annotation 4 GLY B 618
THR B 588
ALA B 589
ALA B 590
None
0.59A 2ej3A-5efnB:
undetectable
2ej3A-5efnB:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ex8 CYTOCHROME P450

(Streptomyces
toyocaensis)
PF00067
(p450)
4 GLY A  74
THR A  75
ALA A  76
ALA A  77
None
0.52A 2ej3A-5ex8A:
undetectable
2ej3A-5ex8A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmg PROTEASOME COMPONENT
C8, PUTATIVE
PROTEOSOME SUBUNIT
ALPHA TYPE 1,
PUTATIVE


(Plasmodium
falciparum)
PF00227
(Proteasome)
PF10584
(Proteasome_A_N)
4 TYR F  13
GLY G  85
ALA G 135
ALA G 136
None
0.59A 2ej3A-5fmgF:
undetectable
2ej3A-5fmgF:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5v FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 2


(Escherichia
coli)
PF02465
(FliD_N)
PF07195
(FliD_C)
4 GLY A 345
THR A 363
ALA A 364
ALA A 365
None
0.38A 2ej3A-5h5vA:
undetectable
2ej3A-5h5vA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig1 CAMK/CAMK2 PROTEIN
KINASE


(Salpingoeca
rosetta)
PF00069
(Pkinase)
4 GLY A 282
THR A 246
ALA A 247
ALA A 248
None
0.30A 2ej3A-5ig1A:
undetectable
2ej3A-5ig1A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbk BETA-GLUCOSIDASE

(Trichoderma
harzianum)
PF00232
(Glyco_hydro_1)
5 TYR A 429
GLU A  19
GLY A  20
THR A  50
ALA A  51
None
1.50A 2ej3A-5jbkA:
undetectable
2ej3A-5jbkA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jd4 LAE6

(uncultured
bacterium)
PF07859
(Abhydrolase_3)
4 TYR A 189
GLY A 163
ALA A 161
ALA A 162
None
None
BAM  A 407 (-3.1A)
BAM  A 407 (-3.2A)
0.59A 2ej3A-5jd4A:
undetectable
2ej3A-5jd4A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lew DNA POLYMERASE III
SUBUNIT ALPHA


(Mycobacterium
tuberculosis)
no annotation 5 ARG A 667
GLY A 383
GLY A 790
ALA A 788
ALA A 789
None
1.42A 2ej3A-5lewA:
undetectable
2ej3A-5lewA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mjk THIOREDOXIN
REDUCTASE


(Lactococcus
lactis)
PF07992
(Pyr_redox_2)
4 GLY A  12
THR A  19
ALA A  20
ALA A  21
FAD  A 401 (-3.3A)
None
None
None
0.51A 2ej3A-5mjkA:
undetectable
2ej3A-5mjkA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqz PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE


(Archaeoglobus
fulgidus)
no annotation 7 TYR A  87
ARG A  89
GLY A 186
GLY A 245
THR A 246
ALA A 247
ALA A 248
None
None
LLP  A 150 ( 3.9A)
LLP  A 150 ( 3.4A)
LLP  A 150 ( 3.7A)
None
None
0.28A 2ej3A-5mqzA:
39.3
2ej3A-5mqzA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncc FATTY ACID
PHOTODECARBOXYLASE


(Chlorella
variabilis)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
4 GLY A  92
THR A  93
ALA A  94
ALA A  95
FAD  A 701 (-3.3A)
FAD  A 701 (-3.1A)
FAD  A 701 (-3.6A)
None
0.32A 2ej3A-5nccA:
undetectable
2ej3A-5nccA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ttk AMINE OXIDASE

(Pseudomonas
putida)
PF01593
(Amino_oxidase)
4 GLY A  60
THR A  67
ALA A  68
ALA A  69
FAD  A 501 (-3.1A)
None
None
None
0.53A 2ej3A-5ttkA:
undetectable
2ej3A-5ttkA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u3f BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE


(Mycobacterium
tuberculosis)
PF01063
(Aminotran_4)
6 TYR A 144
ARG A 146
GLY A 243
GLY A 313
THR A 314
ALA A 315
7TS  A 400 (-4.6A)
None
7TS  A 400 (-3.4A)
7TS  A 400 (-3.6A)
7TS  A 400 (-3.6A)
None
0.49A 2ej3A-5u3fA:
33.6
2ej3A-5u3fA:
29.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u3f BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE


(Mycobacterium
tuberculosis)
PF01063
(Aminotran_4)
4 TYR A 144
THR A 314
ALA A 315
ALA A 316
7TS  A 400 (-4.6A)
7TS  A 400 (-3.6A)
None
None
0.56A 2ej3A-5u3fA:
33.6
2ej3A-5u3fA:
29.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uos METHYLMALONIC
ACIDURIA AND
HOMOCYSTINURIA TYPE
C PROTEIN


(Homo sapiens)
PF16690
(MMACHC)
4 TYR A  31
THR A 119
ALA A 120
ALA A 121
None
B12  A 301 ( 2.7A)
None
None
0.56A 2ej3A-5uosA:
undetectable
2ej3A-5uosA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vye L-THREONINE ALDOLASE

(Pseudomonas
putida)
no annotation 5 GLY A 213
GLY A  64
THR A  65
ALA A  66
ALA A  67
None
PLR  A 401 (-2.8A)
PLR  A 401 (-3.8A)
None
None
0.64A 2ej3A-5vyeA:
undetectable
2ej3A-5vyeA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cbl NEAMINE TRANSAMINASE
NEON


(Streptomyces
fradiae)
no annotation 4 GLY A 104
THR A 105
ALA A 106
ALA A 107
DOW  A 501 (-3.3A)
DOW  A 501 (-3.6A)
None
None
0.58A 2ej3A-6cblA:
undetectable
2ej3A-6cblA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B


(Pyrococcus
furiosus)
no annotation 5 GLY D  75
GLY F  47
THR F  44
ALA F  43
ALA F  46
None
1.10A 2ej3A-6cfwD:
undetectable
2ej3A-6cfwD:
16.90