SIMILAR PATTERNS OF AMINO ACIDS FOR 2EIN_J_CHDJ60_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a7j PHOSPHORIBULOKINASE

(Rhodobacter
sphaeroides) 		PF00485
(PRK) 		4 ILE A 233
PHE A 235
THR A 277
LEU A 276
 None
 0.81A 2einA-1a7jA:
undetectable
2einJ-1a7jA:
undetectable		 2einA-1a7jA:
20.11
2einJ-1a7jA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1brt BROMOPEROXIDASE A2

(Kitasatospora
aureofaciens) 		PF00561
(Abhydrolase_1) 		4 ILE A 148
PHE A 144
ARG A 229
LEU A 231
 None
 0.90A 2einA-1brtA:
0.0
2einJ-1brtA:
0.0		 2einA-1brtA:
20.34
2einJ-1brtA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d0b INTERNALIN B

(Listeria
monocytogenes) 		PF12354
(Internalin_N)
PF12799
(LRR_4) 		5 ILE A 179
LEU A 193
ARG A 184
THR A 186
LEU A 207
 None
 1.46A 2einA-1d0bA:
undetectable
2einJ-1d0bA:
0.0		 2einA-1d0bA:
17.05
2einJ-1d0bA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flo FLP RECOMBINASE

(Saccharomyces
cerevisiae) 		PF03930
(Flp_N)
PF05202
(Flp_C) 		5 ILE A 350
ARG A 308
MET A 311
THR A 312
LEU A 315
 None
 1.07A 2einA-1floA:
0.0
2einJ-1floA:
0.0		 2einA-1floA:
21.78
2einJ-1floA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0d PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE

(Pagrus major) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		4 ILE A 128
ARG A  14
THR A  96
LEU A  97
 None
 0.93A 2einA-1g0dA:
0.0
2einJ-1g0dA:
0.0		 2einA-1g0dA:
19.23
2einJ-1g0dA:
6.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl6 ATPASE

(Escherichia
coli) 		PF10412
(TrwB_AAD_bind) 		4 ILE A 355
LEU A 358
ARG A 380
LEU A 371
 None
 0.93A 2einA-1gl6A:
0.0
2einJ-1gl6A:
0.0		 2einA-1gl6A:
21.30
2einJ-1gl6A:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus 1) 		PF00078
(RVT_1) 		4 LEU A 109
MET A 164
THR A 165
LEU A 168
 None
 0.79A 2einA-1harA:
undetectable
2einJ-1harA:
0.1		 2einA-1harA:
18.00
2einJ-1harA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ihp PHYTASE

(Aspergillus
ficuum) 		PF00328
(His_Phos_2) 		4 LEU A 261
PHE A 262
THR A 230
LEU A 229
 None
 0.93A 2einA-1ihpA:
0.0
2einJ-1ihpA:
0.0		 2einA-1ihpA:
21.69
2einJ-1ihpA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jed SULFATE
ADENYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		5 ILE A  48
LEU A  49
ARG A  40
THR A  38
LEU A  37
 None
 0.94A 2einA-1jedA:
0.0
2einJ-1jedA:
undetectable		 2einA-1jedA:
21.17
2einJ-1jedA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1knr L-ASPARTATE OXIDASE

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 ILE A  53
PHE A 104
ARG A 138
THR A 142
LEU A 144
 None
 1.34A 2einA-1knrA:
0.0
2einJ-1knrA:
undetectable		 2einA-1knrA:
20.83
2einJ-1knrA:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01063
(Aminotran_4) 		4 ILE A 332
MET A 293
THR A 292
LEU A 235
 None
 0.74A 2einA-1kt8A:
0.0
2einJ-1kt8A:
undetectable		 2einA-1kt8A:
22.71
2einJ-1kt8A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1

(Paracoccus
denitrificans) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		4 ARG A 383
MET A 416
THR A 437
LEU A 436
 None
 0.88A 2einA-1lrwA:
undetectable
2einJ-1lrwA:
undetectable		 2einA-1lrwA:
21.34
2einJ-1lrwA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mg1 PROTEIN (HTLV-1 GP21
ECTODOMAIN/MALTOSE-B
INDING PROTEIN
CHIMERA)

(Primate
T-lymphotropic
virus 1) 		PF00429
(TLV_coat)
PF13416
(SBP_bac_8) 		4 ILE A  60
PHE A  62
THR A 287
LEU A 286
 None
 0.93A 2einA-1mg1A:
undetectable
2einJ-1mg1A:
2.3		 2einA-1mg1A:
20.70
2einJ-1mg1A:
7.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mow CHIMERA OF HOMING
ENDONUCLEASE I-DMOI
AND DNA ENDONUCLEASE
I-CREI

(Desulfurococcus
mucosus;
Chlamydomonas
reinhardtii) 		PF00961
(LAGLIDADG_1)
PF14528
(LAGLIDADG_3) 		4 ILE A  18
PHE A  91
ARG A  55
MET A  56
 None
None
SO4  A 271 (-3.1A)
None
 0.88A 2einA-1mowA:
2.1
2einJ-1mowA:
undetectable		 2einA-1mowA:
18.60
2einJ-1mowA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1no8 ALY

(Mus musculus) 		PF00076
(RRM_1) 		5 ILE A 121
LEU A 124
PHE A 125
MET A 175
LEU A 170
 None
 1.29A 2einA-1no8A:
undetectable
2einJ-1no8A:
undetectable		 2einA-1no8A:
11.24
2einJ-1no8A:
28.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pm2 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 1
BETA CHAIN

(Escherichia
coli) 		PF00268
(Ribonuc_red_sm) 		5 ILE A 335
LEU A 339
TYR A 310
ARG A 328
THR A 312
 None
None
None
HG  A 614 ( 4.9A)
None
 1.27A 2einA-1pm2A:
1.8
2einJ-1pm2A:
undetectable		 2einA-1pm2A:
19.19
2einJ-1pm2A:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qh4 CREATINE KINASE

(Gallus gallus) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		4 ILE A 297
LEU A 299
ARG A 320
LEU A 312
 None
 0.84A 2einA-1qh4A:
undetectable
2einJ-1qh4A:
undetectable		 2einA-1qh4A:
20.15
2einJ-1qh4A:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6x ATP:SULFATE
ADENYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		5 ILE A  48
LEU A  49
ARG A  40
THR A  38
LEU A  37
 None
 0.96A 2einA-1r6xA:
undetectable
2einJ-1r6xA:
undetectable		 2einA-1r6xA:
21.48
2einJ-1r6xA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rt8 FIMBRIN

(Schizosaccharomyces
pombe) 		PF00307
(CH) 		4 ILE A 475
LEU A 486
THR A 392
LEU A 395
 None
 0.92A 2einA-1rt8A:
undetectable
2einJ-1rt8A:
undetectable		 2einA-1rt8A:
22.05
2einJ-1rt8A:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rtg HUMAN GELATINASE A

(Homo sapiens) 		PF00045
(Hemopexin) 		4 ILE A 478
PHE A 632
ARG A 500
LEU A 623
 None
 0.91A 2einA-1rtgA:
undetectable
2einJ-1rtgA:
undetectable		 2einA-1rtgA:
17.56
2einJ-1rtgA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ska 3-PHYTASE A

(Aspergillus
fumigatus) 		PF00328
(His_Phos_2) 		4 LEU A 261
PHE A 262
THR A 230
LEU A 229
 None
 0.79A 2einA-1skaA:
undetectable
2einJ-1skaA:
undetectable		 2einA-1skaA:
19.89
2einJ-1skaA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1su7 CARBON MONOXIDE
DEHYDROGENASE 2

(Carboxydothermus
hydrogenoformans) 		PF03063
(Prismane) 		4 LEU A 151
PHE A 154
MET A 225
LEU A 229
 None
 0.86A 2einA-1su7A:
2.2
2einJ-1su7A:
undetectable		 2einA-1su7A:
22.01
2einJ-1su7A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tmx HYDROXYQUINOL
1,2-DIOXYGENASE

(Pimelobacter
simplex) 		PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N) 		4 ILE A 238
LEU A 222
PHE A 224
TYR A 187
 None
 0.93A 2einA-1tmxA:
undetectable
2einJ-1tmxA:
undetectable		 2einA-1tmxA:
20.53
2einJ-1tmxA:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uv7 GENERAL SECRETION
PATHWAY PROTEIN M

(Vibrio cholerae) 		PF04612
(T2SSM) 		4 ILE A 143
LEU A 159
ARG A 147
LEU A 120
 None
 0.92A 2einA-1uv7A:
undetectable
2einJ-1uv7A:
undetectable		 2einA-1uv7A:
11.07
2einJ-1uv7A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vqt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Thermotoga
maritima) 		PF00215
(OMPdecase) 		4 ILE A 143
ARG A 118
MET A 116
LEU A 112
 None
 0.77A 2einA-1vqtA:
undetectable
2einJ-1vqtA:
undetectable		 2einA-1vqtA:
17.18
2einJ-1vqtA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wn0 HISTIDINE-CONTAINING
PHOSPHOTRANSFER
PROTEIN

(Zea mays) 		PF01627
(Hpt) 		5 LEU A  30
PHE A  27
MET A 134
THR A 133
LEU A 135
 None
 1.31A 2einA-1wn0A:
2.5
2einJ-1wn0A:
undetectable		 2einA-1wn0A:
13.04
2einJ-1wn0A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xio ANABAENA SENSORY
RHODOPSIN

(Nostoc sp. PCC
7120) 		PF01036
(Bac_rhodopsin) 		4 LEU A  84
TYR A 165
ARG A 151
THR A 170
 None
None
PEE  A 306 (-3.9A)
None
 0.85A 2einA-1xioA:
1.7
2einJ-1xioA:
undetectable		 2einA-1xioA:
21.56
2einJ-1xioA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xl8 PEROXISOMAL
CARNITINE
O-OCTANOYLTRANSFERAS
E

(Mus musculus) 		PF00755
(Carn_acyltransf) 		4 ILE A 192
LEU A 273
PHE A 274
LEU A 211
 None
 0.87A 2einA-1xl8A:
undetectable
2einJ-1xl8A:
undetectable		 2einA-1xl8A:
19.90
2einJ-1xl8A:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ycg NITRIC OXIDE
REDUCTASE

(Moorella
thermoacetica) 		PF00258
(Flavodoxin_1)
PF00753
(Lactamase_B) 		4 ILE A 367
LEU A 340
ARG A 305
LEU A 277
 None
 0.84A 2einA-1ycgA:
undetectable
2einJ-1ycgA:
undetectable		 2einA-1ycgA:
22.05
2einJ-1ycgA:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c6w PENICILLIN-BINDING
PROTEIN 1A

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		4 TYR B 618
ARG B 619
MET B 622
THR B 623
 None
 0.87A 2einA-2c6wB:
undetectable
2einJ-2c6wB:
undetectable		 2einA-2c6wB:
21.23
2einJ-2c6wB:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfo GLUTAMYL-TRNA
SYNTHETASE

(Synechococcus
elongatus) 		PF00749
(tRNA-synt_1c) 		4 LEU A  39
PHE A  37
ARG A  21
LEU A  15
 None
 0.91A 2einA-2cfoA:
2.9
2einJ-2cfoA:
undetectable		 2einA-2cfoA:
21.24
2einJ-2cfoA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dx5 VACUOLAR PROTEIN
SORTING PROTEIN 36

(Mus musculus) 		PF11605
(Vps36_ESCRT-II) 		5 ILE A  82
LEU A 108
PHE A 110
ARG A 120
LEU A  42
 None
 1.23A 2einA-2dx5A:
undetectable
2einJ-2dx5A:
undetectable		 2einA-2dx5A:
12.45
2einJ-2dx5A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e9q 11S GLOBULIN SUBUNIT
BETA

(Cucurbita
maxima) 		PF00190
(Cupin_1) 		4 LEU A 137
ARG A  67
THR A  69
LEU A 155
 None
 0.90A 2einA-2e9qA:
undetectable
2einJ-2e9qA:
undetectable		 2einA-2e9qA:
19.40
2einJ-2e9qA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fc9 NCL PROTEIN

(Homo sapiens) 		PF00076
(RRM_1) 		4 ILE A  58
PHE A  36
ARG A  84
LEU A  23
 None
 0.89A 2einA-2fc9A:
undetectable
2einJ-2fc9A:
undetectable		 2einA-2fc9A:
10.27
2einJ-2fc9A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g2o MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Escherichia
coli) 		PF00698
(Acyl_transf_1) 		4 LEU A  44
PHE A  33
THR A  15
LEU A  56
 None
 0.91A 2einA-2g2oA:
undetectable
2einJ-2g2oA:
undetectable		 2einA-2g2oA:
22.25
2einJ-2g2oA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ghs AGR_C_1268P

(Agrobacterium
fabrum) 		PF08450
(SGL) 		5 ILE A 151
LEU A 162
PHE A 163
THR A 180
LEU A 196
 None
 1.16A 2einA-2ghsA:
undetectable
2einJ-2ghsA:
undetectable		 2einA-2ghsA:
21.64
2einJ-2ghsA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		4 LEU A 109
MET A 164
THR A 165
LEU A 168
 None
 0.82A 2einA-2hnzA:
2.6
2einJ-2hnzA:
undetectable		 2einA-2hnzA:
19.77
2einJ-2hnzA:
6.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ho5 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY

(Streptococcus
pneumoniae) 		PF01408
(GFO_IDH_MocA) 		4 LEU A 189
PHE A 190
THR A 244
LEU A 245
 None
 0.93A 2einA-2ho5A:
undetectable
2einJ-2ho5A:
undetectable		 2einA-2ho5A:
20.46
2einJ-2ho5A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2idc ANTI-SILENCING
PROTEIN 1 AND
HISTONE H3 CHIMERA

(Saccharomyces
cerevisiae) 		PF04729
(ASF1_hist_chap) 		4 ILE A   9
ARG A 108
THR A  43
LEU A  42
 None
 0.79A 2einA-2idcA:
undetectable
2einJ-2idcA:
undetectable		 2einA-2idcA:
13.97
2einJ-2idcA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jzn MANNOSE-SPECIFIC
PHOSPHOTRANSFERASE
ENZYME IIA COMPONENT

(Escherichia
coli) 		PF03610
(EIIA-man) 		4 ILE A   3
LEU A 114
PHE A 111
LEU A  65
 None
 0.93A 2einA-2jznA:
undetectable
2einJ-2jznA:
undetectable		 2einA-2jznA:
15.94
2einJ-2jznA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kbq HARMONIN

(Homo sapiens) 		no annotation 4 ILE A  50
LEU A  58
TYR A  74
LEU A  30
 None
 0.77A 2einA-2kbqA:
undetectable
2einJ-2kbqA:
undetectable		 2einA-2kbqA:
8.84
2einJ-2kbqA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2knh PROTEIN CBFA2T1

(Homo sapiens) 		PF07531
(TAFH) 		4 LEU A 333
PHE A 332
THR A 279
LEU A 278
 None
 0.90A 2einA-2knhA:
undetectable
2einJ-2knhA:
undetectable		 2einA-2knhA:
11.32
2einJ-2knhA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2la7 UNCHARACTERIZED
PROTEIN

(Paraburkholderia
xenovorans) 		PF03724
(META) 		4 LEU A 112
ARG A 117
THR A 137
LEU A 138
 None
 0.74A 2einA-2la7A:
undetectable
2einJ-2la7A:
undetectable		 2einA-2la7A:
14.14
2einJ-2la7A:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m6k FERRIENTEROBACTIN-BI
NDING PERIPLASMIC
PROTEIN

(Escherichia
coli) 		PF01497
(Peripla_BP_2) 		4 ILE A 142
LEU A 117
THR A  38
LEU A  39
 None
 0.88A 2einA-2m6kA:
undetectable
2einJ-2m6kA:
undetectable		 2einA-2m6kA:
18.83
2einJ-2m6kA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlw EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT 9

(Homo sapiens) 		PF00076
(RRM_1) 		4 ILE A  38
PHE A  42
THR A  91
LEU A  86
 None
 0.88A 2einA-2nlwA:
undetectable
2einJ-2nlwA:
undetectable		 2einA-2nlwA:
12.55
2einJ-2nlwA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0d RHO
GTPASE-ACTIVATING
PROTEIN 9

(Homo sapiens) 		PF00169
(PH) 		4 ILE A 405
LEU A 390
THR A 353
LEU A 352
 None
 0.76A 2einA-2p0dA:
undetectable
2einJ-2p0dA:
undetectable		 2einA-2p0dA:
12.67
2einJ-2p0dA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE X 252
MET X 356
THR X 357
LEU X 360
 None
 0.78A 2einA-2p3gX:
undetectable
2einJ-2p3gX:
undetectable		 2einA-2p3gX:
19.81
2einJ-2p3gX:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3x POLYPHENOL OXIDASE,
CHLOROPLAST

(Vitis vinifera) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		4 LEU A 128
PHE A 137
TYR A  58
LEU A 163
 None
 0.66A 2einA-2p3xA:
undetectable
2einJ-2p3xA:
undetectable		 2einA-2p3xA:
19.17
2einJ-2p3xA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q7s N-FORMYLGLUTAMATE
AMIDOHYDROLASE

(Cupriavidus
pinatubonensis) 		PF05013
(FGase) 		4 ILE A 250
PHE A 192
ARG A 272
THR A 275
 None
 0.91A 2einA-2q7sA:
undetectable
2einJ-2q7sA:
undetectable		 2einA-2q7sA:
19.19
2einJ-2q7sA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvf EXOPOLYGALACTURONASE

(Yersinia
enterocolitica) 		PF00295
(Glyco_hydro_28)
PF12708
(Pectate_lyase_3) 		4 PHE A 347
MET A 334
THR A 335
LEU A 336
 None
 0.79A 2einA-2uvfA:
undetectable
2einJ-2uvfA:
undetectable		 2einA-2uvfA:
22.56
2einJ-2uvfA:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uw1 PLASTID DELTA4
MULTIFUNCTIONAL
ACYL-ACYL CARRIER
PROTEIN DESATURASE

(Hedera helix) 		PF03405
(FA_desaturase_2) 		4 LEU B 272
MET B 346
THR B 345
LEU B 358
 None
 0.89A 2einA-2uw1B:
undetectable
2einJ-2uw1B:
undetectable		 2einA-2uw1B:
20.56
2einJ-2uw1B:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9p REPLICATION PROTEIN
E1

(Deltapapillomavirus
4) 		PF00519
(PPV_E1_C) 		4 ILE A 503
LEU A 466
ARG A 473
LEU A 518
 None
 0.90A 2einA-2v9pA:
undetectable
2einJ-2v9pA:
undetectable		 2einA-2v9pA:
19.27
2einJ-2v9pA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd2 ATP
PHOSPHORIBOSYLTRANSF
ERASE

(Bacillus
subtilis) 		PF01634
(HisG) 		5 LEU A 203
PHE A 182
MET A   7
THR A   6
LEU A  48
 None
 1.38A 2einA-2vd2A:
undetectable
2einJ-2vd2A:
undetectable		 2einA-2vd2A:
16.70
2einJ-2vd2A:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ws9 P1

(Equine rhinitis
A virus) 		no annotation 4 LEU 1  84
PHE 1 156
THR 1 198
LEU 1 197
 None
 0.87A 2einA-2ws91:
undetectable
2einJ-2ws91:
undetectable		 2einA-2ws91:
19.07
2einJ-2ws91:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wy0 ANGIOTENSINOGEN

(Mus musculus) 		PF00079
(Serpin) 		4 LEU C 309
ARG C 345
THR C 423
LEU C 424
 None
 0.76A 2einA-2wy0C:
undetectable
2einJ-2wy0C:
undetectable		 2einA-2wy0C:
21.21
2einJ-2wy0C:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3c TOXIC EXTRACELLULAR
ENDOPEPTIDASE

(Aeromonas
salmonicida) 		PF14521
(Aspzincin_M35) 		4 LEU A  67
PHE A  68
THR A  43
LEU A  44
 None
 0.75A 2einA-2x3cA:
undetectable
2einJ-2x3cA:
undetectable		 2einA-2x3cA:
20.64
2einJ-2x3cA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7j 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE
-1-CARBOXYLATE
SYNTHASE

(Bacillus
subtilis) 		PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
PF16582
(TPP_enzyme_M_2) 		4 ILE A 311
LEU A 305
ARG A 282
LEU A 275
 None
 0.90A 2einA-2x7jA:
undetectable
2einJ-2x7jA:
undetectable		 2einA-2x7jA:
23.17
2einJ-2x7jA:
7.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xe4 OLIGOPEPTIDASE B

(Leishmania
major) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 ILE A 183
ARG A 231
MET A 234
THR A 213
 None
 0.90A 2einA-2xe4A:
undetectable
2einJ-2xe4A:
undetectable		 2einA-2xe4A:
19.95
2einJ-2xe4A:
6.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xri ERI1 EXORIBONUCLEASE
3

(Homo sapiens) 		PF00929
(RNase_T) 		5 ILE A 170
LEU A 149
PHE A 242
TYR A 268
LEU A 221
 None
 1.33A 2einA-2xriA:
undetectable
2einJ-2xriA:
undetectable		 2einA-2xriA:
17.13
2einJ-2xriA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwb COMPLEMENT C3B
ALPHA' CHAIN

(Homo sapiens) 		PF00207
(A2M)
PF01759
(NTR)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		4 ILE B 958
LEU B1276
THR B 924
LEU B 925
 None
 0.84A 2einA-2xwbB:
1.7
2einJ-2xwbB:
undetectable		 2einA-2xwbB:
20.77
2einJ-2xwbB:
5.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xxl GRAM-POSITIVE
SPECIFIC SERINE
PROTEASE, ISOFORM B

(Drosophila
melanogaster) 		PF00089
(Trypsin)
PF12032
(CLIP) 		5 LEU A 244
PHE A 104
ARG A 156
MET A 372
LEU A 226
 None
 1.07A 2einA-2xxlA:
undetectable
2einJ-2xxlA:
undetectable		 2einA-2xxlA:
19.17
2einJ-2xxlA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y24 XYLANASE

(Dickeya
chrysanthemi) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		4 ILE A  75
LEU A  77
THR A  60
LEU A  59
 None
 0.75A 2einA-2y24A:
undetectable
2einJ-2y24A:
undetectable		 2einA-2y24A:
22.63
2einJ-2y24A:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y69 CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1

(Bos taurus) 		PF02238
(COX7a) 		5 TYR J  32
ARG J  33
MET J  36
THR J  37
LEU J  40
 None
 0.46A 2einA-2y69J:
undetectable
2einJ-2y69J:
7.8		 2einA-2y69J:
10.31
2einJ-2y69J:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yhe SEC-ALKYL SULFATASE

(Pseudomonas sp.
DSM 6611) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		4 ILE A 617
PHE A 646
THR A 606
LEU A 635
 None
 0.78A 2einA-2yheA:
undetectable
2einJ-2yheA:
undetectable		 2einA-2yheA:
20.41
2einJ-2yheA:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yrf METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE

(Bacillus
subtilis) 		PF01008
(IF-2B) 		4 ILE A 242
PHE A 277
MET A 335
THR A 336
 None
 0.84A 2einA-2yrfA:
undetectable
2einJ-2yrfA:
undetectable		 2einA-2yrfA:
20.95
2einJ-2yrfA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z17 PLECKSTRIN HOMOLOGY
SEC7 AND COILED-COIL
DOMAINS-BINDING
PROTEIN

(Homo sapiens) 		PF00595
(PDZ) 		4 ILE A  33
LEU A  72
ARG A  93
LEU A  99
 None
 0.92A 2einA-2z17A:
undetectable
2einJ-2z17A:
undetectable		 2einA-2z17A:
11.11
2einJ-2z17A:
27.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ze0 ALPHA-GLUCOSIDASE

(Geobacillus sp.
HTA-462) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 ILE A 193
LEU A  97
PHE A 196
MET A 184
 None
 0.82A 2einA-2ze0A:
undetectable
2einJ-2ze0A:
undetectable		 2einA-2ze0A:
19.59
2einJ-2ze0A:
7.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zgk ANTI-TUMOR LECTIN

(Agrocybe
aegerita) 		PF00337
(Gal-bind_lectin) 		4 ILE A 115
PHE A  93
THR A  46
LEU A  47
 None
 0.81A 2einA-2zgkA:
undetectable
2einJ-2zgkA:
undetectable		 2einA-2zgkA:
15.56
2einJ-2zgkA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ziu MUS81 PROTEIN

(Danio rerio) 		PF02732
(ERCC4) 		4 TYR A 471
MET A 475
THR A 476
LEU A 479
 None
 0.78A 2einA-2ziuA:
undetectable
2einJ-2ziuA:
undetectable		 2einA-2ziuA:
18.55
2einJ-2ziuA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zts PUTATIVE
UNCHARACTERIZED
PROTEIN PH0186

(Pyrococcus
horikoshii) 		PF06745
(ATPase) 		4 ILE A 127
PHE A 123
THR A 178
LEU A 177
 None
 0.76A 2einA-2ztsA:
undetectable
2einJ-2ztsA:
undetectable		 2einA-2ztsA:
17.81
2einJ-2ztsA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2d CD180 ANTIGEN

(Homo sapiens) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 ILE A 352
LEU A 377
THR A 348
LEU A 372
 None
 0.79A 2einA-3b2dA:
undetectable
2einJ-3b2dA:
undetectable		 2einA-3b2dA:
20.65
2einJ-3b2dA:
7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b46 AMINOTRANSFERASE
BNA3

(Saccharomyces
cerevisiae) 		PF00155
(Aminotran_1_2) 		4 ILE A 343
LEU A 347
PHE A 344
LEU A 396
 None
 0.91A 2einA-3b46A:
undetectable
2einJ-3b46A:
undetectable		 2einA-3b46A:
22.55
2einJ-3b46A:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b57 LIN1889 PROTEIN

(Listeria
innocua) 		PF01966
(HD) 		4 ILE A  30
PHE A  18
THR A  73
LEU A  76
 None
 0.89A 2einA-3b57A:
undetectable
2einJ-3b57A:
undetectable		 2einA-3b57A:
16.01
2einJ-3b57A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4

(Homo sapiens) 		PF00168
(C2) 		5 PHE A 189
ARG A 124
MET A 248
THR A 249
LEU A 213
 None
 1.34A 2einA-3b7yA:
undetectable
2einJ-3b7yA:
undetectable		 2einA-3b7yA:
13.39
2einJ-3b7yA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4

(Homo sapiens) 		PF00168
(C2) 		5 PHE A 229
ARG A 124
MET A 248
THR A 249
LEU A 213
 None
 1.49A 2einA-3b7yA:
undetectable
2einJ-3b7yA:
undetectable		 2einA-3b7yA:
13.39
2einJ-3b7yA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c9b VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 75

(Saccharomyces
cerevisiae) 		PF00956
(NAP) 		4 ILE A  80
LEU A  62
ARG A  73
LEU A 200
 None
 0.88A 2einA-3c9bA:
undetectable
2einJ-3c9bA:
undetectable		 2einA-3c9bA:
16.41
2einJ-3c9bA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3m EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4
GAMMA 2

(Homo sapiens) 		PF02020
(W2) 		4 ILE A 861
MET A 773
THR A 774
LEU A 777
 None
 0.78A 2einA-3d3mA:
undetectable
2einJ-3d3mA:
undetectable		 2einA-3d3mA:
15.54
2einJ-3d3mA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dby UNCHARACTERIZED
PROTEIN

(Bacillus cereus) 		PF11155
(DUF2935) 		4 LEU A  53
PHE A  50
ARG A  77
LEU A 115
 None
 0.80A 2einA-3dbyA:
2.8
2einJ-3dbyA:
undetectable		 2einA-3dbyA:
17.09
2einJ-3dbyA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dcp HISTIDINOL-PHOSPHATA
SE

(Listeria
monocytogenes) 		PF02811
(PHP)
PF13263
(PHP_C) 		4 LEU A  30
PHE A  32
TYR A 255
THR A 271
 None
 0.75A 2einA-3dcpA:
undetectable
2einJ-3dcpA:
undetectable		 2einA-3dcpA:
19.37
2einJ-3dcpA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwv GLUTATHIONE
PEROXIDASE-LIKE
PROTEIN

(Trypanosoma
brucei) 		PF00255
(GSHPx) 		4 ILE A  15
LEU A  30
PHE A  16
ARG A 146
 None
 0.93A 2einA-3dwvA:
undetectable
2einJ-3dwvA:
undetectable		 2einA-3dwvA:
16.96
2einJ-3dwvA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7f 6-PHOSPHOGLUCONOLACT
ONASE

(Trypanosoma
brucei) 		PF01182
(Glucosamine_iso) 		4 ILE A 230
LEU A 231
THR A 219
LEU A 255
 None
 0.83A 2einA-3e7fA:
undetectable
2einJ-3e7fA:
undetectable		 2einA-3e7fA:
19.65
2einJ-3e7fA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f95 BETA-GLUCOSIDASE

(Pseudoalteromonas
sp. BB1) 		no annotation 5 ILE A 784
PHE A 747
ARG A 721
MET A 720
LEU A 718
 None
 1.40A 2einA-3f95A:
undetectable
2einJ-3f95A:
undetectable		 2einA-3f95A:
17.88
2einJ-3f95A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE

(Comamonas
testosteroni) 		PF00155
(Aminotran_1_2) 		4 ILE A 475
LEU A 483
ARG A 516
LEU A 423
 None
 0.84A 2einA-3fddA:
undetectable
2einJ-3fddA:
undetectable		 2einA-3fddA:
21.01
2einJ-3fddA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 ILE A 462
ARG A 397
THR A 395
LEU A 410
 None
 0.80A 2einA-3fg4A:
2.0
2einJ-3fg4A:
undetectable		 2einA-3fg4A:
20.56
2einJ-3fg4A:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fss HISTONE CHAPERONE
RTT106

(Saccharomyces
cerevisiae) 		PF08512
(Rtt106) 		4 ILE A 200
MET A 158
THR A 159
LEU A 160
 None
 0.89A 2einA-3fssA:
undetectable
2einJ-3fssA:
undetectable		 2einA-3fssA:
19.04
2einJ-3fssA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gf6 UNCHARACTERIZED
BACTERIAL
LIPOPROTEIN

(Bacteroides
thetaiotaomicron) 		PF12956
(DUF3845) 		5 LEU A 216
TYR A  68
MET A 105
THR A 104
LEU A 103
 None
 1.50A 2einA-3gf6A:
undetectable
2einJ-3gf6A:
undetectable		 2einA-3gf6A:
19.49
2einJ-3gf6A:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzy BIPHENYL DIOXYGENASE
SUBUNIT BETA

(Comamonas
testosteroni) 		PF00866
(Ring_hydroxyl_B) 		4 ILE B 165
LEU B  48
ARG B  31
LEU B  36
 None
 0.92A 2einA-3gzyB:
undetectable
2einJ-3gzyB:
undetectable		 2einA-3gzyB:
15.34
2einJ-3gzyB:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5t TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Corynebacterium
glutamicum) 		PF00356
(LacI)
PF13377
(Peripla_BP_3) 		4 ILE A 147
LEU A 152
THR A 331
LEU A 332
 None
 0.77A 2einA-3h5tA:
undetectable
2einJ-3h5tA:
undetectable		 2einA-3h5tA:
21.02
2einJ-3h5tA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7n NUCLEOPORIN NUP120

(Saccharomyces
cerevisiae) 		PF11715
(Nup160) 		4 ILE A  95
PHE A  81
THR A 109
LEU A 108
 None
 0.84A 2einA-3h7nA:
2.5
2einJ-3h7nA:
undetectable		 2einA-3h7nA:
21.45
2einJ-3h7nA:
7.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hi8 PROLIFERATING CELL
NUCLEAR ANTIGEN PCNA

(Haloferax
volcanii) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 LEU A  15
ARG A  37
THR A  50
LEU A  51
 None
 0.80A 2einA-3hi8A:
undetectable
2einJ-3hi8A:
undetectable		 2einA-3hi8A:
20.53
2einJ-3hi8A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn5 PUTATIVE EXPORTED
PROTEIN BF0290

(Bacteroides
fragilis) 		PF12866
(DUF3823) 		4 ILE A 105
ARG A  36
THR A  34
LEU A  33
 None
 0.79A 2einA-3hn5A:
undetectable
2einJ-3hn5A:
undetectable		 2einA-3hn5A:
17.12
2einJ-3hn5A:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvd PROTECTIVE ANTIGEN

(Bacillus
anthracis) 		PF03495
(Binary_toxB)
PF17475
(Binary_toxB_2)
PF17476
(Binary_toxB_3) 		4 ILE A 591
PHE A 552
THR A 522
LEU A 583
 None
 0.84A 2einA-3hvdA:
undetectable
2einJ-3hvdA:
undetectable		 2einA-3hvdA:
21.11
2einJ-3hvdA:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ix1 N-FORMYL-4-AMINO-5-A
MINOMETHYL-2-METHYLP
YRIMIDINE BINDING
PROTEIN

(Bacillus
halodurans) 		PF09084
(NMT1) 		5 ILE A  66
LEU A  37
PHE A  68
THR A 262
LEU A 260
 None
 1.11A 2einA-3ix1A:
undetectable
2einJ-3ix1A:
undetectable		 2einA-3ix1A:
19.80
2einJ-3ix1A:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4p CAPSID PROTEIN VP1

(Adeno-associated
virus) 		PF00740
(Parvo_coat) 		4 ILE A 374
LEU A 249
ARG A 245
LEU A 317
 None
 0.90A 2einA-3j4pA:
undetectable
2einJ-3j4pA:
undetectable		 2einA-3j4pA:
22.36
2einJ-3j4pA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4u MAJOR CAPSID PROTEIN

(Bordetella
virus BPP1) 		no annotation 4 ILE A  38
LEU A 130
PHE A 131
LEU A 183
 None
 0.90A 2einA-3j4uA:
undetectable
2einJ-3j4uA:
undetectable		 2einA-3j4uA:
21.07
2einJ-3j4uA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE

(Cupriavidus
pinatubonensis) 		PF00465
(Fe-ADH) 		4 ILE A 343
LEU A 346
ARG A 322
LEU A 248
 None
 0.92A 2einA-3jzdA:
undetectable
2einJ-3jzdA:
undetectable		 2einA-3jzdA:
22.15
2einJ-3jzdA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k13 5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE

(Bacteroides
thetaiotaomicron) 		PF00809
(Pterin_bind) 		4 ARG A 407
MET A 410
THR A 411
LEU A 414
 None
 0.68A 2einA-3k13A:
undetectable
2einJ-3k13A:
undetectable		 2einA-3k13A:
20.20
2einJ-3k13A:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1r HARMONIN

(Homo sapiens) 		PF00595
(PDZ) 		4 ILE A  50
LEU A  58
TYR A  74
LEU A  30
 None
 0.85A 2einA-3k1rA:
undetectable
2einJ-3k1rA:
undetectable		 2einA-3k1rA:
14.45
2einJ-3k1rA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kuq RHO
GTPASE-ACTIVATING
PROTEIN 7

(Homo sapiens) 		PF00620
(RhoGAP) 		4 ILE A1186
PHE A1170
ARG A1198
LEU A1205
 None
 0.87A 2einA-3kuqA:
undetectable
2einJ-3kuqA:
undetectable		 2einA-3kuqA:
17.51
2einJ-3kuqA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzx HAD-SUPERFAMILY
HYDROLASE, SUBFAMILY
IA, VARIANT 1

(Ehrlichia
chaffeensis) 		PF13419
(HAD_2) 		5 ILE A 180
LEU A 192
PHE A 194
ARG A 201
LEU A 207
 None
 1.36A 2einA-3kzxA:
undetectable
2einJ-3kzxA:
undetectable		 2einA-3kzxA:
17.44
2einJ-3kzxA:
11.26