SIMILAR PATTERNS OF AMINO ACIDS FOR 2EIM_W_CHDW1271_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1914 SIGNAL RECOGNITION
PARTICLE 9/14 FUSION
PROTEIN

(Mus musculus) 		PF02290
(SRP14)
PF05486
(SRP9-21) 		4 LEU A2086
PHE A2017
LEU A2013
PHE A2009
 None
 0.88A 2eimP-1914A:
undetectable
2eimW-1914A:
undetectable		 2eimP-1914A:
19.40
2eimW-1914A:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1buc BUTYRYL-COA
DEHYDROGENASE

(Megasphaera
elsdenii) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ARG A  31
LEU A  41
PHE A  19
LEU A  24
 None
 0.99A 2eimP-1bucA:
3.7
2eimW-1bucA:
0.0		 2eimP-1bucA:
17.69
2eimW-1bucA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj3 ADENYLOSUCCINATE
SYNTHETASE

(Triticum
aestivum) 		PF00709
(Adenylsucc_synt) 		4 LEU A 164
PHE A 175
LEU A 179
PHE A 183
 None
 0.73A 2eimP-1dj3A:
undetectable
2eimW-1dj3A:
0.0		 2eimP-1dj3A:
19.00
2eimW-1dj3A:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dq3 ENDONUCLEASE

(Pyrococcus
furiosus) 		PF09061
(Stirrup)
PF09062
(Endonuc_subdom)
PF14528
(LAGLIDADG_3)
PF14890
(Intein_splicing) 		4 LEU A 342
PHE A 347
PHE A 108
LEU A 104
 None
 0.96A 2eimP-1dq3A:
undetectable
2eimW-1dq3A:
undetectable		 2eimP-1dq3A:
17.80
2eimW-1dq3A:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e2t N-HYDROXYARYLAMINE
O-ACETYLTRANSFERASE

(Salmonella
enterica) 		PF00797
(Acetyltransf_2) 		4 ARG A  88
LEU A  90
PHE A 174
LEU A 176
 None
 1.02A 2eimP-1e2tA:
undetectable
2eimW-1e2tA:
0.0		 2eimP-1e2tA:
23.15
2eimW-1e2tA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fqt RIESKE-TYPE
FERREDOXIN OF
BIPHENYL DIOXYGENASE

(Paraburkholderia
xenovorans) 		PF00355
(Rieske) 		4 LYS A  87
LEU A  86
PHE A  70
LEU A  50
 None
 0.94A 2eimP-1fqtA:
undetectable
2eimW-1fqtA:
undetectable		 2eimP-1fqtA:
15.48
2eimW-1fqtA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g59 GLUTAMYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00749
(tRNA-synt_1c) 		4 LYS A 149
LEU A 148
LEU A 219
PHE A 223
 None
 0.92A 2eimP-1g59A:
undetectable
2eimW-1g59A:
0.0		 2eimP-1g59A:
18.76
2eimW-1g59A:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jkw CYCLIN H

(Homo sapiens) 		PF00134
(Cyclin_N)
PF16899
(Cyclin_C_2) 		4 ARG A 102
LEU A 106
PHE A 110
LEU A 129
 None
 0.93A 2eimP-1jkwA:
undetectable
2eimW-1jkwA:
0.0		 2eimP-1jkwA:
20.52
2eimW-1jkwA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js6 DOPA DECARBOXYLASE

(Sus scrofa) 		PF00282
(Pyridoxal_deC) 		4 LEU A 114
PHE A 357
LEU A 360
PHE A 364
 None
 0.93A 2eimP-1js6A:
undetectable
2eimW-1js6A:
0.0		 2eimP-1js6A:
19.84
2eimW-1js6A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lam LEUCINE
AMINOPEPTIDASE

(Bos taurus) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		4 LEU A  57
PHE A  61
PHE A  27
LEU A  35
 None
 1.04A 2eimP-1lamA:
undetectable
2eimW-1lamA:
undetectable		 2eimP-1lamA:
19.35
2eimW-1lamA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1miq PLASMEPSIN

(Plasmodium
vivax) 		PF00026
(Asp) 		4 LEU A 126
PHE A 154
LEU A 168
PHE A  83
 None
 1.04A 2eimP-1miqA:
undetectable
2eimW-1miqA:
undetectable		 2eimP-1miqA:
20.42
2eimW-1miqA:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ny5 TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)

(Aquifex
aeolicus) 		PF00072
(Response_reg)
PF00158
(Sigma54_activat) 		4 LEU A 194
PHE A 204
LEU A 208
PHE A 227
 None
 1.02A 2eimP-1ny5A:
undetectable
2eimW-1ny5A:
undetectable		 2eimP-1ny5A:
19.75
2eimW-1ny5A:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sk7 HYPOTHETICAL PROTEIN
PA-HO

(Pseudomonas
aeruginosa) 		PF01126
(Heme_oxygenase) 		4 LYS A  34
PHE A 197
LEU A 193
PHE A 189
 None
None
None
HEM  A 300 (-3.7A)
 0.91A 2eimP-1sk7A:
1.7
2eimW-1sk7A:
undetectable		 2eimP-1sk7A:
21.29
2eimW-1sk7A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u8v GAMMA-AMINOBUTYRATE
METABOLISM
DEHYDRATASE/ISOMERAS
E

(Clostridium
aminobutyricum) 		PF03241
(HpaB)
PF11794
(HpaB_N) 		4 ARG A 433
LEU A 437
LEU A 391
PHE A 422
 None
 0.82A 2eimP-1u8vA:
3.8
2eimW-1u8vA:
undetectable		 2eimP-1u8vA:
19.70
2eimW-1u8vA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vku ACYL CARRIER PROTEIN

(Thermotoga
maritima) 		PF00550
(PP-binding) 		4 LEU A  70
PHE A  48
LEU A  44
PHE A  36
 None
 0.76A 2eimP-1vkuA:
undetectable
2eimW-1vkuA:
undetectable		 2eimP-1vkuA:
13.64
2eimW-1vkuA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8s FRUCTOSE-BISPHOSPHAT
E ALDOLASE CLASS I

(Thermoproteus
tenax) 		PF01791
(DeoC) 		4 LYS A 215
LEU A 214
PHE A 243
LEU A 247
 None
 0.97A 2eimP-1w8sA:
undetectable
2eimW-1w8sA:
undetectable		 2eimP-1w8sA:
22.11
2eimW-1w8sA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1za4 THROMBOSPONDIN 1

(Homo sapiens) 		PF02210
(Laminin_G_2) 		4 LEU A 173
PHE A  57
LEU A  89
PHE A  99
 None
 1.04A 2eimP-1za4A:
undetectable
2eimW-1za4A:
undetectable		 2eimP-1za4A:
20.43
2eimW-1za4A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bec CALCINEURIN B
HOMOLOGOUS PROTEIN 2

(Homo sapiens) 		PF13202
(EF-hand_5)
PF13499
(EF-hand_7) 		4 ARG A 112
LEU A 116
PHE A 120
LEU A 181
 None
 1.05A 2eimP-2becA:
undetectable
2eimW-2becA:
undetectable		 2eimP-2becA:
25.67
2eimW-2becA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpy FLAGELLUM-SPECIFIC
ATP SYNTHASE

(Salmonella
enterica) 		PF00006
(ATP-synt_ab) 		4 LEU A 428
PHE A 431
PHE A 391
LEU A 395
 None
 0.90A 2eimP-2dpyA:
undetectable
2eimW-2dpyA:
undetectable		 2eimP-2dpyA:
20.50
2eimW-2dpyA:
7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2haj DNA PRIMASE

(Escherichia
coli) 		PF08278
(DnaG_DnaB_bind) 		4 LEU A 454
PHE A 535
LEU A 539
PHE A 543
 None
 0.79A 2eimP-2hajA:
undetectable
2eimW-2hajA:
undetectable		 2eimP-2hajA:
19.01
2eimW-2hajA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibd POSSIBLE
TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF00440
(TetR_N) 		4 LEU A 131
PHE A 135
PHE A  74
LEU A  70
 None
 0.87A 2eimP-2ibdA:
undetectable
2eimW-2ibdA:
undetectable		 2eimP-2ibdA:
24.73
2eimW-2ibdA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lkl ERYTHROCYTE MEMBRANE
PROTEIN 1 (PFEMP1)

(Plasmodium
falciparum) 		PF15445
(ATS) 		4 LEU A  54
PHE A  21
LEU A  17
PHE A   9
 None
 0.91A 2eimP-2lklA:
undetectable
2eimW-2lklA:
undetectable		 2eimP-2lklA:
13.41
2eimW-2lklA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nt8 COBALAMIN
ADENOSYLTRANSFERASE

(Lactobacillus
reuteri) 		PF01923
(Cob_adeno_trans) 		4 LEU A  95
PHE A 154
LEU A 158
PHE A 162
 None
 0.90A 2eimP-2nt8A:
2.7
2eimW-2nt8A:
undetectable		 2eimP-2nt8A:
21.30
2eimW-2nt8A:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2opt ACTII PROTEIN

(Streptomyces
coelicolor) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		4 ARG A  75
LEU A  79
PHE A  83
LEU A  49
 None
 0.69A 2eimP-2optA:
2.9
2eimW-2optA:
undetectable		 2eimP-2optA:
23.19
2eimW-2optA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2otn DIAMINOPIMELATE
EPIMERASE

(Bacillus
anthracis) 		PF01678
(DAP_epimerase) 		4 ARG A  81
LYS A 271
LEU A 258
LEU A  12
 None
 0.68A 2eimP-2otnA:
undetectable
2eimW-2otnA:
undetectable		 2eimP-2otnA:
21.78
2eimW-2otnA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qhp FRUCTOKINASE

(Bacteroides
thetaiotaomicron) 		PF00294
(PfkB) 		4 LYS A 175
LEU A 174
PHE A 168
LEU A 202
 None
None
EDO  A 298 ( 4.9A)
EDO  A 298 (-4.9A)
 0.97A 2eimP-2qhpA:
undetectable
2eimW-2qhpA:
undetectable		 2eimP-2qhpA:
21.57
2eimW-2qhpA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvp UNCHARACTERIZED
PROTEIN

(Shewanella
amazonensis) 		PF04952
(AstE_AspA) 		4 ARG A  36
LEU A  37
PHE A  96
LEU A  91
 None
 0.99A 2eimP-2qvpA:
undetectable
2eimW-2qvpA:
undetectable		 2eimP-2qvpA:
21.97
2eimW-2qvpA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2riu 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE

(Candida
albicans) 		PF00926
(DHBP_synthase) 		4 LEU A 113
PHE A  93
PHE A 123
LEU A  70
 None
 0.94A 2eimP-2riuA:
undetectable
2eimW-2riuA:
undetectable		 2eimP-2riuA:
21.66
2eimW-2riuA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wrd HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 LYS A 106
LEU A 109
PHE A 115
LEU A 176
 None
 0.99A 2eimP-2wrdA:
undetectable
2eimW-2wrdA:
undetectable		 2eimP-2wrdA:
18.97
2eimW-2wrdA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynm LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N

(Prochlorococcus
marinus) 		PF00148
(Oxidored_nitro) 		4 LEU C  35
PHE C  60
PHE C  33
LEU C  87
 None
 1.04A 2eimP-2ynmC:
undetectable
2eimW-2ynmC:
undetectable		 2eimP-2ynmC:
21.92
2eimW-2ynmC:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b86 GENERAL
ODORANT-BINDING
PROTEIN LUSH

(Drosophila
melanogaster) 		PF01395
(PBP_GOBP) 		4 LEU A  44
PHE A  21
LEU A  31
PHE A  36
 None
 1.01A 2eimP-3b86A:
undetectable
2eimW-3b86A:
undetectable		 2eimP-3b86A:
17.60
2eimW-3b86A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ba3 PYRIDOXAMINE
5'-PHOSPHATE
OXIDASE-LIKE PROTEIN

(Lactobacillus
plantarum) 		no annotation 4 LEU A 123
PHE A 121
PHE A  45
LEU A  18
 None
 0.92A 2eimP-3ba3A:
undetectable
2eimW-3ba3A:
undetectable		 2eimP-3ba3A:
21.19
2eimW-3ba3A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3deg GTP-BINDING PROTEIN
LEPA

(Escherichia
coli) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF06421
(LepA_C) 		4 LEU C  73
PHE C  75
PHE C   7
LEU C 176
 None
 1.00A 2eimP-3degC:
undetectable
2eimW-3degC:
undetectable		 2eimP-3degC:
17.43
2eimW-3degC:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e4e CYTOCHROME P450 2E1

(Homo sapiens) 		PF00067
(p450) 		4 LYS A 461
LEU A 460
PHE A 458
LEU A 312
 None
 0.98A 2eimP-3e4eA:
undetectable
2eimW-3e4eA:
undetectable		 2eimP-3e4eA:
19.83
2eimW-3e4eA:
7.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1z PUTATIVE LYSYL-TRNA
SYNTHETASE

(Salmonella
enterica) 		PF00152
(tRNA-synt_2) 		4 ARG A 188
LEU A 192
PHE A 196
PHE A 153
 None
 0.82A 2eimP-3g1zA:
undetectable
2eimW-3g1zA:
undetectable		 2eimP-3g1zA:
20.94
2eimW-3g1zA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gaj COBALAMIN
ADENOSYLTRANSFERASE
PDUO-LIKE PROTEIN

(Lactobacillus
reuteri) 		PF01923
(Cob_adeno_trans) 		4 LEU A  95
PHE A 154
LEU A 158
PHE A 162
 None
 0.89A 2eimP-3gajA:
2.7
2eimW-3gajA:
undetectable		 2eimP-3gajA:
21.16
2eimW-3gajA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrt METALLOREGULATOR
SCAR

(Streptococcus
gordonii) 		PF01325
(Fe_dep_repress)
PF02742
(Fe_dep_repr_C)
PF04023
(FeoA) 		4 ARG A  74
LYS A  75
LEU A  78
PHE A  82
 None
 0.73A 2eimP-3hrtA:
undetectable
2eimW-3hrtA:
undetectable		 2eimP-3hrtA:
18.61
2eimW-3hrtA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iv0 SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 LEU A 230
PHE A 151
LEU A 155
PHE A 159
 None
 0.95A 2eimP-3iv0A:
1.9
2eimW-3iv0A:
undetectable		 2eimP-3iv0A:
20.57
2eimW-3iv0A:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9d OUTER CAPSID PROTEIN
VP2

(Bluetongue
virus) 		PF00898
(Orbi_VP2) 		4 LEU A 530
PHE A 569
LEU A 566
PHE A 526
 None
 0.97A 2eimP-3j9dA:
undetectable
2eimW-3j9dA:
undetectable		 2eimP-3j9dA:
13.31
2eimW-3j9dA:
5.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb4 VP3

(Parechovirus B) 		PF00073
(Rhv) 		4 LYS C 132
PHE C 129
LEU C 201
PHE C 103
 None
 1.05A 2eimP-3jb4C:
undetectable
2eimW-3jb4C:
undetectable		 2eimP-3jb4C:
19.72
2eimW-3jb4C:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1l FANCL

(Drosophila
melanogaster) 		no annotation 4 LYS B 233
LEU B 232
PHE B 285
LEU B 281
 None
 1.04A 2eimP-3k1lB:
undetectable
2eimW-3k1lB:
undetectable		 2eimP-3k1lB:
21.37
2eimW-3k1lB:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6x SOLUTE-BINDING
PROTEIN MA_0280

(Methanosarcina
acetivorans) 		PF13531
(SBP_bac_11) 		4 LEU A  58
PHE A 311
LEU A 315
PHE A 118
 None
 0.93A 2eimP-3k6xA:
undetectable
2eimW-3k6xA:
undetectable		 2eimP-3k6xA:
20.87
2eimW-3k6xA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lcr TAUTOMYCETIN
BIOSYNTHETIC PKS

(Streptomyces
sp. CK4412) 		PF00975
(Thioesterase) 		4 LEU A 229
PHE A 174
LEU A 178
PHE A 182
 None
 0.96A 2eimP-3lcrA:
undetectable
2eimW-3lcrA:
undetectable		 2eimP-3lcrA:
20.45
2eimW-3lcrA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ner CYTOCHROME B5 TYPE B

(Homo sapiens) 		PF00173
(Cyt-b5) 		4 LYS A  72
LEU A  71
PHE A  58
PHE A  35
 None
HEM  A 201 (-4.7A)
HEM  A 201 (-4.7A)
HEM  A 201 (-4.1A)
 1.03A 2eimP-3nerA:
undetectable
2eimW-3nerA:
undetectable		 2eimP-3nerA:
17.37
2eimW-3nerA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogr BETA-GALACTOSIDASE

(Trichoderma
reesei) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 PHE A 327
PHE A 299
LEU A 296
PHE A 294
 None
 0.96A 2eimP-3ogrA:
undetectable
2eimW-3ogrA:
undetectable		 2eimP-3ogrA:
14.48
2eimW-3ogrA:
4.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4i PHOSPHOHYDROLASE
(MUTT/NUDIX FAMILY
PROTEIN)

(Bacillus cereus) 		PF00293
(NUDIX)
PF12535
(Nudix_N) 		4 PHE A 130
PHE A 148
LEU A  94
PHE A  83
 None
 1.00A 2eimP-3q4iA:
3.5
2eimW-3q4iA:
undetectable		 2eimP-3q4iA:
20.44
2eimW-3q4iA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q8i ODORANT BINDING
PROTEIN

(Anopheles
gambiae) 		PF01395
(PBP_GOBP) 		4 LEU A  44
PHE A  21
LEU A  31
PHE A  36
 None
 1.03A 2eimP-3q8iA:
undetectable
2eimW-3q8iA:
undetectable		 2eimP-3q8iA:
17.72
2eimW-3q8iA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rd5 MYPAA.01249.C

(Mycobacterium
avium) 		PF00106
(adh_short) 		4 ARG A 131
LEU A 191
PHE A 246
LEU A 241
 None
 1.03A 2eimP-3rd5A:
undetectable
2eimW-3rd5A:
undetectable		 2eimP-3rd5A:
21.79
2eimW-3rd5A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4y PROTEIN MXIG

(Shigella
flexneri) 		PF09480
(PrgH) 		4 LYS A 106
LEU A 105
PHE A 103
PHE A  79
 None
 0.65A 2eimP-4a4yA:
undetectable
2eimW-4a4yA:
undetectable		 2eimP-4a4yA:
19.17
2eimW-4a4yA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4abn TETRATRICOPEPTIDE
REPEAT PROTEIN 5

(Mus musculus) 		PF16669
(TTC5_OB) 		4 LYS A 281
PHE A 355
LEU A 274
PHE A 405
 None
 0.95A 2eimP-4abnA:
3.3
2eimW-4abnA:
undetectable		 2eimP-4abnA:
19.53
2eimW-4abnA:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c8q DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1

(Saccharomyces
cerevisiae) 		PF09770
(PAT1) 		4 LEU H 562
PHE H 587
LEU H 527
PHE H 523
 None
 0.76A 2eimP-4c8qH:
undetectable
2eimW-4c8qH:
undetectable		 2eimP-4c8qH:
19.40
2eimW-4c8qH:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cn8 PROXIMAL THREAD
MATRIX PROTEIN 1

(Mytilus
galloprovincialis) 		PF00092
(VWA) 		4 LYS A 234
LEU A 233
PHE A  79
LEU A  83
 None
 0.87A 2eimP-4cn8A:
undetectable
2eimW-4cn8A:
undetectable		 2eimP-4cn8A:
20.00
2eimW-4cn8A:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4drs PYRUVATE KINASE

(Cryptosporidium
parvum) 		PF00224
(PK)
PF02887
(PK_C) 		4 ARG A  93
LEU A  89
PHE A 224
LEU A 230
 ACT  A 607 (-4.1A)
ACT  A 607 ( 4.9A)
None
None
 1.02A 2eimP-4drsA:
undetectable
2eimW-4drsA:
undetectable		 2eimP-4drsA:
18.80
2eimW-4drsA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e5t MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME, C-TERMINAL
DOMAIN PROTEIN

(Labrenzia
alexandrii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 321
PHE A  23
PHE A  25
LEU A 376
 None
 0.93A 2eimP-4e5tA:
undetectable
2eimW-4e5tA:
undetectable		 2eimP-4e5tA:
21.58
2eimW-4e5tA:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eco UNCHARACTERIZED
PROTEIN

(Bacteroides
eggerthii) 		no annotation 4 LYS A 613
LEU A 614
LEU A 628
PHE A 652
 None
 0.86A 2eimP-4ecoA:
undetectable
2eimW-4ecoA:
undetectable		 2eimP-4ecoA:
16.35
2eimW-4ecoA:
6.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4flx DNA POLYMERASE 1

(Pyrococcus
abyssi) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 ARG A 266
LEU A 352
PHE A 356
LEU A 333
 ARG  A 266 ( 0.6A)
LEU  A 352 ( 0.6A)
PHE  A 356 ( 1.3A)
LEU  A 333 ( 0.6A)
 0.97A 2eimP-4flxA:
2.6
2eimW-4flxA:
undetectable		 2eimP-4flxA:
13.49
2eimW-4flxA:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9b BETA-PHOSPHOGLUCOMUT
ASE

(Escherichia
coli) 		PF13419
(HAD_2) 		4 LEU A 114
PHE A   8
PHE A 134
LEU A 125
 None
 1.05A 2eimP-4g9bA:
undetectable
2eimW-4g9bA:
undetectable		 2eimP-4g9bA:
21.31
2eimW-4g9bA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hqf THROMBOSPONDIN-RELAT
ED ANONYMOUS
PROTEIN, TRAP

(Plasmodium
falciparum) 		PF00092
(VWA) 		5 ARG A 176
LYS A 173
LEU A 172
PHE A 198
LEU A 202
 None
 1.03A 2eimP-4hqfA:
undetectable
2eimW-4hqfA:
undetectable		 2eimP-4hqfA:
20.74
2eimW-4hqfA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1s MELANOMA
DIFFERENTIATION
ASSOCIATED PROTEIN-5

(Sus scrofa) 		PF00271
(Helicase_C) 		4 LYS A 681
LEU A 684
PHE A 549
LEU A 553
 None
 0.72A 2eimP-4i1sA:
2.2
2eimW-4i1sA:
undetectable		 2eimP-4i1sA:
19.63
2eimW-4i1sA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0m SERINE/THREONINE-PRO
TEIN KINASE
BRI1-LIKE 1

(Arabidopsis
thaliana) 		PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 LEU A 228
PHE A 230
LEU A 203
PHE A 199
 None
 0.99A 2eimP-4j0mA:
undetectable
2eimW-4j0mA:
undetectable		 2eimP-4j0mA:
16.01
2eimW-4j0mA:
5.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l4u TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)

(Aquifex
aeolicus) 		PF00072
(Response_reg)
PF00158
(Sigma54_activat) 		4 LEU A 194
PHE A 204
LEU A 208
PHE A 227
 None
 0.99A 2eimP-4l4uA:
undetectable
2eimW-4l4uA:
undetectable		 2eimP-4l4uA:
18.32
2eimW-4l4uA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgl GLYCINE
DEHYDROGENASE
[DECARBOXYLATING]

(Synechocystis
sp. PCC 6803) 		PF02347
(GDC-P) 		4 LYS A 376
LEU A 375
PHE A 291
PHE A 497
 None
 0.80A 2eimP-4lglA:
undetectable
2eimW-4lglA:
undetectable		 2eimP-4lglA:
13.79
2eimW-4lglA:
4.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6q VOSA

(Aspergillus
nidulans) 		PF11754
(Velvet) 		4 LYS A 132
LEU A 131
PHE A 129
LEU A 121
 None
 0.77A 2eimP-4n6qA:
undetectable
2eimW-4n6qA:
undetectable		 2eimP-4n6qA:
22.18
2eimW-4n6qA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q62 LEUCINE-RICH
REPEAT-AND COILED
COIL-CONTAINING
PROTEIN

(Legionella
pneumophila) 		PF13855
(LRR_8) 		5 LYS A 159
LEU A 161
PHE A 179
PHE A 164
LEU A 136
 None
 1.49A 2eimP-4q62A:
undetectable
2eimW-4q62A:
undetectable		 2eimP-4q62A:
18.18
2eimW-4q62A:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qb7 UNCHARACTERIZED
PROTEIN

(Bacteroides
vulgatus) 		PF13149
(Mfa_like_1) 		5 LYS A 214
PHE A 245
PHE A 290
LEU A 288
PHE A 254
 None
 1.30A 2eimP-4qb7A:
undetectable
2eimW-4qb7A:
undetectable		 2eimP-4qb7A:
19.89
2eimW-4qb7A:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0m MCYG PROTEIN

(Microcystis
aeruginosa) 		no annotation 4 LEU B  75
PHE B  83
LEU B  87
PHE B  91
 None
 0.82A 2eimP-4r0mB:
undetectable
2eimW-4r0mB:
undetectable		 2eimP-4r0mB:
17.42
2eimW-4r0mB:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rjk ACETOLACTATE
SYNTHASE

(Bacillus
subtilis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 LEU A 213
PHE A 345
LEU A 353
PHE A 261
 None
 1.05A 2eimP-4rjkA:
undetectable
2eimW-4rjkA:
undetectable		 2eimP-4rjkA:
18.58
2eimW-4rjkA:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnc ESTERASE

(Rhodococcus sp.
ECU1013) 		PF12697
(Abhydrolase_6) 		4 ARG A 196
LEU A 163
PHE A 185
LEU A 189
 None
 0.93A 2eimP-4rncA:
undetectable
2eimW-4rncA:
undetectable		 2eimP-4rncA:
21.32
2eimW-4rncA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4roa SERPIN 2

(Anopheles
gambiae) 		PF00079
(Serpin) 		4 ARG A 384
LEU A 262
PHE A 260
PHE A 380
 None
 0.96A 2eimP-4roaA:
undetectable
2eimW-4roaA:
undetectable		 2eimP-4roaA:
20.50
2eimW-4roaA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxm POSSIBLE SUGAR ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Mannheimia
haemolytica) 		PF13407
(Peripla_BP_4) 		4 LEU A  31
PHE A  29
LEU A  42
PHE A  38
 None
None
None
INS  A 401 (-4.5A)
 0.96A 2eimP-4rxmA:
undetectable
2eimW-4rxmA:
undetectable		 2eimP-4rxmA:
20.81
2eimW-4rxmA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7v PUTATIVE GLYCOSIDASE
PH117-RELATED

(Bacteroides
thetaiotaomicron) 		PF04041
(Glyco_hydro_130) 		4 LYS B 253
LEU B 254
PHE B 317
PHE B 309
 None
 0.82A 2eimP-5a7vB:
undetectable
2eimW-5a7vB:
undetectable		 2eimP-5a7vB:
20.78
2eimW-5a7vB:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aox SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN

(Homo sapiens) 		PF02290
(SRP14) 		4 LEU B  86
PHE B  17
LEU B  13
PHE B   9
 None
 0.84A 2eimP-5aoxB:
undetectable
2eimW-5aoxB:
undetectable		 2eimP-5aoxB:
17.86
2eimW-5aoxB:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ckm MANNAN-BINDING
LECTIN SERINE
PEPTIDASE 2

(Rattus
norvegicus) 		PF00431
(CUB)
PF07645
(EGF_CA) 		4 ARG A  80
LEU A  70
PHE A 111
PHE A  42
 None
 1.00A 2eimP-5ckmA:
undetectable
2eimW-5ckmA:
undetectable		 2eimP-5ckmA:
22.33
2eimW-5ckmA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cww NUCLEOPORIN NUP82
NUCLEOPORIN NUP159

(Chaetomium
thermophilum;
Chaetomium
thermophilum) 		no annotation
no annotation 		4 ARG C1447
LYS C1448
LEU C1451
LEU B 425
 None
 0.94A 2eimP-5cwwC:
undetectable
2eimW-5cwwC:
undetectable		 2eimP-5cwwC:
8.89
2eimW-5cwwC:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d7w SERRALYSIN

(Serratia
marcescens) 		PF00353
(HemolysinCabind)
PF00413
(Peptidase_M10)
PF08548
(Peptidase_M10_C) 		4 LYS A  57
LEU A  58
PHE A  60
LEU A 182
 LYS  A  57 ( 0.0A)
LEU  A  58 ( 0.6A)
PHE  A  60 ( 1.3A)
LEU  A 182 ( 0.6A)
 0.91A 2eimP-5d7wA:
undetectable
2eimW-5d7wA:
undetectable		 2eimP-5d7wA:
19.92
2eimW-5d7wA:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fn3 PRESENILIN-1

(Homo sapiens) 		PF01080
(Presenilin) 		4 LEU B 392
PHE B 388
LEU B 443
PHE B 447
 None
 0.96A 2eimP-5fn3B:
2.2
2eimW-5fn3B:
undetectable		 2eimP-5fn3B:
20.04
2eimW-5fn3B:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g3y ADENYLATE KINSE

(synthetic
construct) 		PF00406
(ADK)
PF05191
(ADK_lid) 		4 LYS A  69
LEU A  72
PHE A  81
LEU A  83
 None
 0.87A 2eimP-5g3yA:
undetectable
2eimW-5g3yA:
undetectable		 2eimP-5g3yA:
19.19
2eimW-5g3yA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hgr ORANGE CAROTENOID
PROTEIN (OCP)

(Nostoc sp. PCC
7120) 		PF02136
(NTF2)
PF09150
(Carot_N) 		4 LYS A  69
LEU A  68
PHE A 109
LEU A 113
 None
None
None
45D  A 501 ( 4.8A)
 1.03A 2eimP-5hgrA:
undetectable
2eimW-5hgrA:
undetectable		 2eimP-5hgrA:
20.25
2eimW-5hgrA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ifn PARASPECKLE
COMPONENT 1

(Homo sapiens) 		PF00076
(RRM_1)
PF08075
(NOPS) 		4 LYS A 161
LEU A 163
LEU A 223
PHE A 221
 None
 1.04A 2eimP-5ifnA:
undetectable
2eimW-5ifnA:
3.2		 2eimP-5ifnA:
17.50
2eimW-5ifnA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ij6 LIPOATE--PROTEIN
LIGASE

(Enterococcus
faecalis) 		PF03099
(BPL_LplA_LipB)
PF10437
(Lip_prot_lig_C) 		4 LEU A 109
PHE A 132
LEU A 150
PHE A  84
 None
 1.01A 2eimP-5ij6A:
undetectable
2eimW-5ij6A:
undetectable		 2eimP-5ij6A:
20.78
2eimW-5ij6A:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ipx ORF49 PROTEIN

(Human
gammaherpesvirus
8) 		PF04793
(Herpes_BBRF1) 		4 LEU A  87
PHE A 204
LEU A 208
PHE A 212
 None
 0.87A 2eimP-5ipxA:
0.0
2eimW-5ipxA:
undetectable		 2eimP-5ipxA:
20.47
2eimW-5ipxA:
11.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5iy5 CYTOCHROME C OXIDASE
SUBUNIT 3

(Bos taurus) 		PF00510
(COX3) 		6 ARG C 156
LYS C 157
LEU C 160
PHE C 164
PHE C 219
LEU C 223
 CHD  C 307 (-4.0A)
None
CHD  C 307 ( 3.9A)
CHD  C 307 (-3.9A)
None
None
 0.28A 2eimP-5iy5C:
36.8
2eimW-5iy5C:
undetectable		 2eimP-5iy5C:
100.00
2eimW-5iy5C:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j44 SERINE PROTEASE SEPA
AUTOTRANSPORTER

(Shigella
flexneri) 		PF02395
(Peptidase_S6) 		4 LYS A 638
LEU A 637
PHE A 608
LEU A 606
 None
 0.89A 2eimP-5j44A:
undetectable
2eimW-5j44A:
undetectable		 2eimP-5j44A:
13.04
2eimW-5j44A:
5.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbg LGP2

(Gallus gallus) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		4 LEU A 385
PHE A 434
LEU A 432
PHE A 360
 None
 0.87A 2eimP-5jbgA:
3.1
2eimW-5jbgA:
undetectable		 2eimP-5jbgA:
15.81
2eimW-5jbgA:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jlt MIDDLE TRANSCRIPTION
REGULATORY PROTEIN
MOTA

(Escherichia
virus T4) 		PF09158
(MotCF) 		4 LYS A 130
LEU A 128
LEU A 121
PHE A 152
 None
 0.99A 2eimP-5jltA:
undetectable
2eimW-5jltA:
undetectable		 2eimP-5jltA:
16.67
2eimW-5jltA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ju6 BETA-GLUCOSIDASE

(Rasamsonia
emersonii) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 ARG A  82
LEU A  83
PHE A  50
LEU A  54
 None
 0.79A 2eimP-5ju6A:
undetectable
2eimW-5ju6A:
undetectable		 2eimP-5ju6A:
13.89
2eimW-5ju6A:
5.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lmg DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1

(Saccharomyces
cerevisiae) 		PF09770
(PAT1) 		4 LEU A 562
PHE A 587
LEU A 527
PHE A 523
 None
 0.80A 2eimP-5lmgA:
3.4
2eimW-5lmgA:
undetectable		 2eimP-5lmgA:
18.33
2eimW-5lmgA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lsk PROTEIN MIS12
HOMOLOG
POLYAMINE-MODULATED
FACTOR 1

(Homo sapiens;
Homo sapiens) 		PF05859
(Mis12)
PF03980
(Nnf1) 		4 LEU A  78
PHE A  79
PHE B  45
LEU B  49
 None
 0.89A 2eimP-5lskA:
undetectable
2eimW-5lskA:
2.7		 2eimP-5lskA:
21.82
2eimW-5lskA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbs BETA-GLUCOSIDASE

(Neurospora
crassa) 		no annotation 4 ARG A  78
LEU A  79
PHE A  46
LEU A  50
 None
 0.87A 2eimP-5nbsA:
undetectable
2eimW-5nbsA:
undetectable		 2eimP-5nbsA:
undetectable
2eimW-5nbsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oen INTERFERON
REGULATORY FACTOR 9

(Mus musculus) 		no annotation 4 PHE A 339
PHE A 322
LEU A 326
PHE A 330
 None
 0.92A 2eimP-5oenA:
undetectable
2eimW-5oenA:
undetectable		 2eimP-5oenA:
undetectable
2eimW-5oenA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojq HAEMOLYSIN
CO-REGULATED PROTEIN

(Vibrio cholerae) 		PF05638
(T6SS_HCP) 		4 LYS 1 114
LEU 1 115
LEU 1 146
PHE 1  70
 None
 0.98A 2eimP-5ojq1:
undetectable
2eimW-5ojq1:
undetectable		 2eimP-5ojq1:
21.66
2eimW-5ojq1:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u47 PENICILLIN BINDING
PROTEIN 2X

(Streptococcus
thermophilus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF03793
(PASTA) 		4 LYS A 167
LEU A 170
LEU A 130
PHE A 155
 None
 0.83A 2eimP-5u47A:
undetectable
2eimW-5u47A:
undetectable		 2eimP-5u47A:
13.82
2eimW-5u47A:
6.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7u TREHALOSE SYNTHASE

(Thermobaculum
terrenum) 		no annotation 4 LEU A  52
PHE A  86
LEU A  35
PHE A  21
 None
 0.91A 2eimP-5x7uA:
undetectable
2eimW-5x7uA:
undetectable		 2eimP-5x7uA:
undetectable
2eimW-5x7uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xge UNCHARACTERIZED
PROTEIN PA0861

(Pseudomonas
aeruginosa) 		no annotation 4 LYS A 699
PHE A 665
LEU A 661
PHE A 657
 None
 0.84A 2eimP-5xgeA:
undetectable
2eimW-5xgeA:
undetectable		 2eimP-5xgeA:
undetectable
2eimW-5xgeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjj MULTI DRUG EFFLUX
TRANSPORTER

(Camelina sativa) 		PF01554
(MatE) 		4 LEU A 348
PHE A 344
PHE A 380
LEU A 376
 None
 0.80A 2eimP-5xjjA:
3.3
2eimW-5xjjA:
undetectable		 2eimP-5xjjA:
22.22
2eimW-5xjjA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bpc RETICULOCYTE BINDING
PROTEIN 2, PUTATIVE

(Plasmodium
vivax) 		no annotation 4 LYS A 437
LEU A 440
PHE A 388
LEU A 392
 None
 0.65A 2eimP-6bpcA:
6.9
2eimW-6bpcA:
undetectable		 2eimP-6bpcA:
undetectable
2eimW-6bpcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c26 DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT 1
DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT OST5

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		no annotation
no annotation 		4 LEU 5  73
PHE 5  28
PHE 5  77
PHE 1 447
 None
 0.95A 2eimP-6c265:
3.3
2eimW-6c265:
undetectable		 2eimP-6c265:
undetectable
2eimW-6c265:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cc4 SOLUBLE CYTOCHROME
B562, LIPID II
FLIPPASE MURJ
CHIMERA

(Escherichia
coli) 		no annotation 4 LEU A 271
PHE A 274
PHE A  22
LEU A 336
 None
 0.88A 2eimP-6cc4A:
2.6
2eimW-6cc4A:
undetectable		 2eimP-6cc4A:
undetectable
2eimW-6cc4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d04 RETICULOCYTE BINDING
PROTEIN 2, PUTATIVE

(Plasmodium
vivax) 		no annotation 4 LYS E 437
LEU E 440
PHE E 388
LEU E 392
 None
 0.78A 2eimP-6d04E:
5.1
2eimW-6d04E:
undetectable		 2eimP-6d04E:
undetectable
2eimW-6d04E:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dex SUPPRESSOR OF
HYDROXYUREA
SENSITIVITY PROTEIN
2

(Eremothecium
gossypii) 		no annotation 4 ARG B  36
LEU B  38
PHE B  39
PHE B 158
 None
 1.01A 2eimP-6dexB:
undetectable
2eimW-6dexB:
undetectable		 2eimP-6dexB:
undetectable
2eimW-6dexB:
undetectable