SIMILAR PATTERNS OF AMINO ACIDS FOR 2EIL_P_CHDP1271_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1914 SIGNAL RECOGNITION
PARTICLE 9/14 FUSION
PROTEIN

(Mus musculus) 		PF02290
(SRP14)
PF05486
(SRP9-21) 		4 LEU A2086
PHE A2017
LEU A2013
PHE A2009
 None
 0.87A 2eilP-1914A:
0.8
2eilW-1914A:
0.0		 2eilP-1914A:
19.40
2eilW-1914A:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1914 SIGNAL RECOGNITION
PARTICLE 9/14 FUSION
PROTEIN

(Mus musculus) 		PF02290
(SRP14)
PF05486
(SRP9-21) 		4 LYS A2066
PHE A2009
LEU A2013
PHE A2017
 None
 0.81A 2eilP-1914A:
0.8
2eilW-1914A:
0.0		 2eilP-1914A:
19.40
2eilW-1914A:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a76 FLAP ENDONUCLEASE-1
PROTEIN

(Methanocaldococcus
jannaschii) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		4 LEU A 214
PHE A   5
LEU A 178
PHE A 265
 None
 0.98A 2eilP-1a76A:
undetectable
2eilW-1a76A:
0.0		 2eilP-1a76A:
19.58
2eilW-1a76A:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1buc BUTYRYL-COA
DEHYDROGENASE

(Megasphaera
elsdenii) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ARG A  31
LEU A  41
PHE A  19
LEU A  24
 None
 0.96A 2eilP-1bucA:
3.8
2eilW-1bucA:
0.0		 2eilP-1bucA:
17.69
2eilW-1bucA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj3 ADENYLOSUCCINATE
SYNTHETASE

(Triticum
aestivum) 		PF00709
(Adenylsucc_synt) 		4 LEU A 164
PHE A 175
LEU A 179
PHE A 183
 None
 0.67A 2eilP-1dj3A:
undetectable
2eilW-1dj3A:
0.0		 2eilP-1dj3A:
19.00
2eilW-1dj3A:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj3 ADENYLOSUCCINATE
SYNTHETASE

(Triticum
aestivum) 		PF00709
(Adenylsucc_synt) 		4 LEU A 200
PHE A 183
LEU A 179
PHE A 175
 None
 0.72A 2eilP-1dj3A:
undetectable
2eilW-1dj3A:
0.0		 2eilP-1dj3A:
19.00
2eilW-1dj3A:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fq9 FIBROBLAST GROWTH
FACTOR 2

(Homo sapiens) 		PF00167
(FGF) 		4 LEU A  53
GLN A  54
LEU A  32
PHE A 139
 None
 0.95A 2eilP-1fq9A:
undetectable
2eilW-1fq9A:
0.0		 2eilP-1fq9A:
19.75
2eilW-1fq9A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fqt RIESKE-TYPE
FERREDOXIN OF
BIPHENYL DIOXYGENASE

(Paraburkholderia
xenovorans) 		PF00355
(Rieske) 		4 LYS A  87
LEU A  86
PHE A  70
LEU A  50
 None
 0.95A 2eilP-1fqtA:
undetectable
2eilW-1fqtA:
0.0		 2eilP-1fqtA:
15.48
2eilW-1fqtA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE

(Escherichia
coli) 		PF00982
(Glyco_transf_20) 		5 GLN A  96
PHE A  97
PHE A  79
LEU A  84
PHE A  88
 None
 1.32A 2eilP-1gz5A:
undetectable
2eilW-1gz5A:
0.0		 2eilP-1gz5A:
19.91
2eilW-1gz5A:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkk CHITOTRIOSIDASE-1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		4 LEU A  66
GLN A  65
LEU A  94
PHE A 132
 None
 0.87A 2eilP-1hkkA:
0.3
2eilW-1hkkA:
0.0		 2eilP-1hkkA:
21.66
2eilW-1hkkA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ji6 PESTICIDIAL CRYSTAL
PROTEIN CRY3BB

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 LEU A 137
GLN A 138
PHE A 141
PHE A 178
 None
 0.97A 2eilP-1ji6A:
3.0
2eilW-1ji6A:
0.0		 2eilP-1ji6A:
19.52
2eilW-1ji6A:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jkw CYCLIN H

(Homo sapiens) 		PF00134
(Cyclin_N)
PF16899
(Cyclin_C_2) 		4 ARG A 102
LEU A 106
PHE A 110
LEU A 129
 None
 0.88A 2eilP-1jkwA:
0.7
2eilW-1jkwA:
undetectable		 2eilP-1jkwA:
20.52
2eilW-1jkwA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqo PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Zea mays) 		PF00311
(PEPcase) 		4 LEU A 871
GLN A 869
PHE A 833
LEU A 829
 None
 0.92A 2eilP-1jqoA:
3.4
2eilW-1jqoA:
undetectable		 2eilP-1jqoA:
13.67
2eilW-1jqoA:
5.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js6 DOPA DECARBOXYLASE

(Sus scrofa) 		PF00282
(Pyridoxal_deC) 		4 LEU A 114
PHE A 357
LEU A 360
PHE A 364
 None
 0.91A 2eilP-1js6A:
undetectable
2eilW-1js6A:
undetectable		 2eilP-1js6A:
19.84
2eilW-1js6A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1juv DIHYDROFOLATE
REDUCTASE

(Escherichia
virus T4) 		PF00186
(DHFR_1) 		4 LEU A  20
GLN A 159
PHE A  22
LEU A 165
 None
None
NDP  A 194 (-3.6A)
None
 0.98A 2eilP-1juvA:
undetectable
2eilW-1juvA:
undetectable		 2eilP-1juvA:
18.99
2eilW-1juvA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kl7 THREONINE SYNTHASE

(Saccharomyces
cerevisiae) 		PF00291
(PALP)
PF14821
(Thr_synth_N) 		4 LEU A  83
PHE A 130
LEU A 134
PHE A 138
 None
 0.91A 2eilP-1kl7A:
undetectable
2eilW-1kl7A:
undetectable		 2eilP-1kl7A:
21.24
2eilW-1kl7A:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lfw PEPV

(Lactobacillus
delbrueckii) 		PF01546
(Peptidase_M20) 		4 LYS A 209
LEU A 207
PHE A 292
LEU A 300
 None
 0.92A 2eilP-1lfwA:
undetectable
2eilW-1lfwA:
undetectable		 2eilP-1lfwA:
19.87
2eilW-1lfwA:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lnl HEMOCYANIN

(Rapana venosa) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 ARG A 217
LEU A 221
GLN A 223
LEU A 287
 None
 0.94A 2eilP-1lnlA:
undetectable
2eilW-1lnlA:
undetectable		 2eilP-1lnlA:
20.98
2eilW-1lnlA:
7.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m33 BIOH PROTEIN

(Escherichia
coli) 		PF00561
(Abhydrolase_1) 		4 LEU A 132
GLN A 131
PHE A 128
LEU A 176
 None
 0.85A 2eilP-1m33A:
undetectable
2eilW-1m33A:
undetectable		 2eilP-1m33A:
20.57
2eilW-1m33A:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n0w DNA REPAIR PROTEIN
RAD51 HOMOLOG 1

(Homo sapiens) 		PF08423
(Rad51) 		4 LEU A 204
GLN A 202
PHE A 248
LEU A 252
 None
 0.98A 2eilP-1n0wA:
undetectable
2eilW-1n0wA:
undetectable		 2eilP-1n0wA:
21.79
2eilW-1n0wA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE

(Escherichia
coli) 		PF04055
(Radical_SAM)
PF06969
(HemN_C) 		5 LEU A 277
GLN A   4
PHE A 284
PHE A 290
PHE A 222
 None
 1.36A 2eilP-1oltA:
undetectable
2eilW-1oltA:
undetectable		 2eilP-1oltA:
20.00
2eilW-1oltA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1onf GLUTATHIONE
REDUCTASE

(Plasmodium
falciparum) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 LYS A 173
LEU A  76
PHE A  74
LEU A 197
 None
 0.97A 2eilP-1onfA:
undetectable
2eilW-1onfA:
undetectable		 2eilP-1onfA:
17.91
2eilW-1onfA:
6.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ovl ORPHAN NUCLEAR
RECEPTOR NURR1 (MSE
496, 511)

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU B 570
GLN B 571
PHE B 574
PHE B 592
 None
 0.65A 2eilP-1ovlB:
undetectable
2eilW-1ovlB:
undetectable		 2eilP-1ovlB:
19.94
2eilW-1ovlB:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ovl ORPHAN NUCLEAR
RECEPTOR NURR1 (MSE
496, 511)

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU B 570
PHE B 574
PHE B 592
LEU B 596
 None
 0.89A 2eilP-1ovlB:
undetectable
2eilW-1ovlB:
undetectable		 2eilP-1ovlB:
19.94
2eilW-1ovlB:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pby QUINOHEMOPROTEIN
AMINE DEHYDROGENASE
60 KDA SUBUNIT

(Paracoccus
denitrificans) 		PF09098
(Dehyd-heme_bind)
PF09099
(Qn_am_d_aIII)
PF09100
(Qn_am_d_aIV)
PF14930
(Qn_am_d_aII) 		4 LYS A 326
LEU A 325
GLN A 293
LEU A 340
 None
 0.86A 2eilP-1pbyA:
undetectable
2eilW-1pbyA:
undetectable		 2eilP-1pbyA:
18.43
2eilW-1pbyA:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qsa PROTEIN (SOLUBLE
LYTIC
TRANSGLYCOSYLASE
SLT70)

(Escherichia
coli) 		PF01464
(SLT)
PF14718
(SLT_L) 		4 LEU A 246
GLN A 245
LEU A 254
PHE A 222
 None
SO4  A 706 (-3.3A)
None
None
 0.98A 2eilP-1qsaA:
undetectable
2eilW-1qsaA:
undetectable		 2eilP-1qsaA:
17.26
2eilW-1qsaA:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sk7 HYPOTHETICAL PROTEIN
PA-HO

(Pseudomonas
aeruginosa) 		PF01126
(Heme_oxygenase) 		4 LYS A  34
PHE A 197
LEU A 193
PHE A 189
 None
None
None
HEM  A 300 (-3.7A)
 0.99A 2eilP-1sk7A:
undetectable
2eilW-1sk7A:
undetectable		 2eilP-1sk7A:
21.29
2eilW-1sk7A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 418
GLN A 420
PHE A 501
LEU A 473
 None
 0.76A 2eilP-1snxA:
undetectable
2eilW-1snxA:
undetectable		 2eilP-1snxA:
19.44
2eilW-1snxA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svr SEVERIN

(Dictyostelium
discoideum) 		PF00626
(Gelsolin) 		4 GLN A 200
PHE A 201
PHE A 245
LEU A 249
 None
 0.84A 2eilP-1svrA:
undetectable
2eilW-1svrA:
undetectable		 2eilP-1svrA:
17.37
2eilW-1svrA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u8v GAMMA-AMINOBUTYRATE
METABOLISM
DEHYDRATASE/ISOMERAS
E

(Clostridium
aminobutyricum) 		PF03241
(HpaB)
PF11794
(HpaB_N) 		4 ARG A 433
LEU A 437
LEU A 391
PHE A 422
 None
 0.86A 2eilP-1u8vA:
3.8
2eilW-1u8vA:
undetectable		 2eilP-1u8vA:
19.70
2eilW-1u8vA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uik ALPHA PRIME SUBUNIT
OF BETA-CONGLYCININ

(Glycine max) 		PF00190
(Cupin_1) 		4 LEU A 387
PHE A 360
LEU A 394
PHE A 481
 None
 0.95A 2eilP-1uikA:
undetectable
2eilW-1uikA:
undetectable		 2eilP-1uikA:
20.00
2eilW-1uikA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uzg MAJOR ENVELOPE
PROTEIN E

(Dengue virus) 		PF00869
(Flavi_glycoprot)
PF02832
(Flavi_glycop_C) 		4 LYS A  47
LEU A  45
GLN A  46
LEU A 281
 None
 0.81A 2eilP-1uzgA:
undetectable
2eilW-1uzgA:
undetectable		 2eilP-1uzgA:
20.75
2eilW-1uzgA:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vku ACYL CARRIER PROTEIN

(Thermotoga
maritima) 		PF00550
(PP-binding) 		4 LEU A  70
PHE A  48
LEU A  44
PHE A  36
 None
 0.85A 2eilP-1vkuA:
undetectable
2eilW-1vkuA:
undetectable		 2eilP-1vkuA:
13.64
2eilW-1vkuA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w61 B-CELL MITOGEN

(Trypanosoma
cruzi) 		PF05544
(Pro_racemase) 		4 LYS A  77
LEU A  80
GLN A  81
LEU A  65
 None
 0.82A 2eilP-1w61A:
undetectable
2eilW-1w61A:
undetectable		 2eilP-1w61A:
20.61
2eilW-1w61A:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wb0 CHITOTRIOSIDASE 1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		4 LEU A  66
GLN A  65
LEU A  94
PHE A 132
 None
 0.80A 2eilP-1wb0A:
undetectable
2eilW-1wb0A:
undetectable		 2eilP-1wb0A:
19.69
2eilW-1wb0A:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wod MODA

(Escherichia
coli) 		PF13531
(SBP_bac_11) 		5 LEU A  80
PHE A 230
PHE A 225
LEU A 216
PHE A 212
 None
 1.28A 2eilP-1wodA:
undetectable
2eilW-1wodA:
undetectable		 2eilP-1wodA:
19.08
2eilW-1wodA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xho CHORISMATE MUTASE

(Ruminiclostridium
thermocellum) 		PF07736
(CM_1) 		4 ARG A  62
GLN A  24
PHE A  46
LEU A  71
 None
 0.87A 2eilP-1xhoA:
undetectable
2eilW-1xhoA:
undetectable		 2eilP-1xhoA:
17.72
2eilW-1xhoA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xw8 UPF0271 PROTEIN YBGL

(Escherichia
coli) 		PF03746
(LamB_YcsF) 		4 LEU A   5
PHE A 235
LEU A 231
PHE A 227
 None
 0.88A 2eilP-1xw8A:
undetectable
2eilW-1xw8A:
undetectable		 2eilP-1xw8A:
18.97
2eilW-1xw8A:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xw8 UPF0271 PROTEIN YBGL

(Escherichia
coli) 		PF03746
(LamB_YcsF) 		5 LEU A 188
GLN A 186
PHE A 227
LEU A 231
PHE A 235
 None
 1.27A 2eilP-1xw8A:
undetectable
2eilW-1xw8A:
undetectable		 2eilP-1xw8A:
18.97
2eilW-1xw8A:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yw6 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Escherichia
coli) 		PF04952
(AstE_AspA) 		4 LEU A 184
PHE A 158
LEU A 176
PHE A 172
 None
 0.88A 2eilP-1yw6A:
undetectable
2eilW-1yw6A:
undetectable		 2eilP-1yw6A:
20.54
2eilW-1yw6A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae) 		PF01263
(Aldose_epim)
PF16363
(GDP_Man_Dehyd) 		4 LEU A 121
GLN A 123
PHE A  80
LEU A  76
 None
 0.89A 2eilP-1z45A:
undetectable
2eilW-1z45A:
undetectable		 2eilP-1z45A:
16.74
2eilW-1z45A:
5.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7m ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT

(Lactococcus
lactis) 		PF13393
(tRNA-synt_His) 		4 LEU A 236
PHE A 240
PHE A 168
LEU A 172
 None
 0.75A 2eilP-1z7mA:
undetectable
2eilW-1z7mA:
undetectable		 2eilP-1z7mA:
20.44
2eilW-1z7mA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zes PHOSPHATE REGULON
TRANSCRIPTIONAL
REGULATORY PROTEIN
PHOB

(Escherichia
coli) 		PF00072
(Response_reg) 		4 LEU A  42
GLN A  41
PHE A  64
LEU A  68
 None
 0.83A 2eilP-1zesA:
undetectable
2eilW-1zesA:
undetectable		 2eilP-1zesA:
16.80
2eilW-1zesA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2brt LEUCOANTHOCYANIDIN
DIOXYGENASE

(Arabidopsis
thaliana) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		4 LEU A 210
GLN A 211
PHE A 304
LEU A 176
 None
None
NAR  A1352 ( 3.5A)
None
 0.98A 2eilP-2brtA:
undetectable
2eilW-2brtA:
undetectable		 2eilP-2brtA:
19.40
2eilW-2brtA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buk COAT PROTEIN

(unidentified
tobacco
necrosis virus) 		PF03898
(TNV_CP) 		4 LEU A 174
GLN A  45
PHE A 172
PHE A  90
 None
 0.86A 2eilP-2bukA:
undetectable
2eilW-2bukA:
undetectable		 2eilP-2bukA:
21.37
2eilW-2bukA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c5q RRAA-LIKE PROTEIN
YER010C

(Saccharomyces
cerevisiae) 		PF03737
(RraA-like) 		4 LYS A 158
LEU A 157
GLN A 156
PHE A  54
 None
None
CME  A 170 ( 4.4A)
None
 0.98A 2eilP-2c5qA:
undetectable
2eilW-2c5qA:
undetectable		 2eilP-2c5qA:
20.79
2eilW-2c5qA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfm THERMOSTABLE DNA
LIGASE

(Pyrococcus
furiosus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 LEU A 522
GLN A 511
PHE A 520
LEU A 428
 None
 0.96A 2eilP-2cfmA:
undetectable
2eilW-2cfmA:
undetectable		 2eilP-2cfmA:
17.30
2eilW-2cfmA:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cmh SPERMIDINE SYNTHASE

(Helicobacter
pylori) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 LEU A  90
GLN A  89
PHE A 144
LEU A 142
 None
 0.92A 2eilP-2cmhA:
undetectable
2eilW-2cmhA:
undetectable		 2eilP-2cmhA:
23.63
2eilW-2cmhA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e8m EPIDERMAL GROWTH
FACTOR RECEPTOR
KINASE SUBSTRATE 8

(Homo sapiens) 		no annotation 4 LYS A  69
LEU A  72
LEU A  64
PHE A  65
 None
 0.98A 2eilP-2e8mA:
undetectable
2eilW-2e8mA:
undetectable		 2eilP-2e8mA:
18.67
2eilW-2e8mA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2egr HYPOTHETICAL PROTEIN
AQ_1494

(Aquifex
aeolicus) 		PF03061
(4HBT) 		5 LYS A 127
PHE A  87
PHE A  89
LEU A  77
PHE A   3
 None
 1.30A 2eilP-2egrA:
undetectable
2eilW-2egrA:
undetectable		 2eilP-2egrA:
18.08
2eilW-2egrA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fnu AMINOTRANSFERASE

(Helicobacter
pylori) 		PF01041
(DegT_DnrJ_EryC1) 		4 LEU A 243
GLN A 242
PHE A  37
LEU A  41
 None
 0.87A 2eilP-2fnuA:
undetectable
2eilW-2fnuA:
undetectable		 2eilP-2fnuA:
20.38
2eilW-2fnuA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fre NAD(P)H-FLAVIN
OXIDOREDUCTASE

(Agrobacterium
fabrum) 		PF00881
(Nitroreductase) 		4 LEU A  73
GLN A  79
PHE A  90
LEU A 147
 None
 0.82A 2eilP-2freA:
undetectable
2eilW-2freA:
undetectable		 2eilP-2freA:
19.72
2eilW-2freA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gnp TRANSCRIPTIONAL
REGULATOR

(Streptococcus
pneumoniae) 		PF04198
(Sugar-bind) 		4 LEU A 258
GLN A 259
LEU A 225
PHE A 230
 None
 0.86A 2eilP-2gnpA:
undetectable
2eilW-2gnpA:
undetectable		 2eilP-2gnpA:
19.19
2eilW-2gnpA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwc GLUTAMATE CYSTEINE
LIGASE

(Brassica juncea) 		PF04107
(GCS2) 		4 LEU A 350
PHE A 349
PHE A 346
LEU A  86
 None
 0.95A 2eilP-2gwcA:
undetectable
2eilW-2gwcA:
undetectable		 2eilP-2gwcA:
19.51
2eilW-2gwcA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2haj DNA PRIMASE

(Escherichia
coli) 		PF08278
(DnaG_DnaB_bind) 		4 LEU A 454
PHE A 535
LEU A 539
PHE A 543
 None
 0.82A 2eilP-2hajA:
undetectable
2eilW-2hajA:
undetectable		 2eilP-2hajA:
19.01
2eilW-2hajA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hdo PHOSPHOGLYCOLATE
PHOSPHATASE

(Lactobacillus
plantarum) 		PF13419
(HAD_2) 		5 LEU A  98
GLN A   4
PHE A 207
LEU A  94
PHE A  91
 None
 1.37A 2eilP-2hdoA:
undetectable
2eilW-2hdoA:
undetectable		 2eilP-2hdoA:
23.44
2eilW-2hdoA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hi3 HOMEODOMAIN-ONLY
PROTEIN

(Mus musculus) 		PF00046
(Homeobox) 		4 ARG A  59
LEU A  55
GLN A  53
PHE A  51
 None
 0.93A 2eilP-2hi3A:
undetectable
2eilW-2hi3A:
undetectable		 2eilP-2hi3A:
13.41
2eilW-2hi3A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6x HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Porphyromonas
gingivalis) 		PF13419
(HAD_2) 		5 LEU A 106
PHE A   7
PHE A 134
LEU A 130
PHE A 123
 None
 1.44A 2eilP-2i6xA:
undetectable
2eilW-2i6xA:
undetectable		 2eilP-2i6xA:
20.30
2eilW-2i6xA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibd POSSIBLE
TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF00440
(TetR_N) 		4 LEU A 131
PHE A 135
PHE A  74
LEU A  70
 None
 0.91A 2eilP-2ibdA:
undetectable
2eilW-2ibdA:
undetectable		 2eilP-2ibdA:
24.73
2eilW-2ibdA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2in3 HYPOTHETICAL PROTEIN

(Nitrosomonas
europaea) 		PF01323
(DSBA) 		4 GLN A 117
PHE A 120
LEU A 133
PHE A 151
 None
 0.87A 2eilP-2in3A:
undetectable
2eilW-2in3A:
undetectable		 2eilP-2in3A:
22.22
2eilW-2in3A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iop CHAPERONE PROTEIN
HTPG

(Escherichia
coli) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		4 LEU A 382
PHE A 378
PHE A 374
LEU A 360
 None
 0.99A 2eilP-2iopA:
undetectable
2eilW-2iopA:
undetectable		 2eilP-2iopA:
16.83
2eilW-2iopA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2irw CORTICOSTEROID
11-BETA-DEHYDROGENAS
E ISOZYME 1

(Homo sapiens) 		PF00106
(adh_short) 		4 LYS A  68
LEU A  71
GLN A  72
PHE A 102
 None
 0.87A 2eilP-2irwA:
1.4
2eilW-2irwA:
undetectable		 2eilP-2irwA:
18.75
2eilW-2irwA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3t TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT 1

(Mus musculus) 		PF04099
(Sybindin) 		4 ARG C  94
GLN C  65
PHE C  64
PHE C  61
 None
 0.96A 2eilP-2j3tC:
undetectable
2eilW-2j3tC:
undetectable		 2eilP-2j3tC:
20.75
2eilW-2j3tC:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lkl ERYTHROCYTE MEMBRANE
PROTEIN 1 (PFEMP1)

(Plasmodium
falciparum) 		PF15445
(ATS) 		4 LEU A  54
PHE A  21
LEU A  17
PHE A   9
 None
 0.91A 2eilP-2lklA:
undetectable
2eilW-2lklA:
undetectable		 2eilP-2lklA:
13.41
2eilW-2lklA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nt8 COBALAMIN
ADENOSYLTRANSFERASE

(Lactobacillus
reuteri) 		PF01923
(Cob_adeno_trans) 		4 LEU A  95
PHE A 154
LEU A 158
PHE A 162
 None
 0.90A 2eilP-2nt8A:
2.7
2eilW-2nt8A:
undetectable		 2eilP-2nt8A:
21.30
2eilW-2nt8A:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3e NEUROLYSIN

(Rattus
norvegicus) 		PF01432
(Peptidase_M3) 		4 LEU A 257
GLN A 258
LEU A 602
PHE A 599
 None
 0.87A 2eilP-2o3eA:
5.0
2eilW-2o3eA:
undetectable		 2eilP-2o3eA:
17.94
2eilW-2o3eA:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oaa R.MVAI

(Kocuria varians) 		PF15515
(MvaI_BcnI) 		4 LEU A 156
GLN A 155
LEU A 190
PHE A 187
 None
 0.98A 2eilP-2oaaA:
undetectable
2eilW-2oaaA:
undetectable		 2eilP-2oaaA:
20.00
2eilW-2oaaA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2olt HYPOTHETICAL PROTEIN

(Shewanella
oneidensis) 		PF01865
(PhoU_div) 		4 LEU A 117
GLN A 118
PHE A 121
LEU A 183
 None
 0.84A 2eilP-2oltA:
3.1
2eilW-2oltA:
undetectable		 2eilP-2oltA:
22.38
2eilW-2oltA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2opt ACTII PROTEIN

(Streptomyces
coelicolor) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		4 ARG A  75
LEU A  79
PHE A  83
LEU A  49
 None
 0.66A 2eilP-2optA:
3.1
2eilW-2optA:
undetectable		 2eilP-2optA:
23.19
2eilW-2optA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2otn DIAMINOPIMELATE
EPIMERASE

(Bacillus
anthracis) 		PF01678
(DAP_epimerase) 		4 ARG A  81
LYS A 271
LEU A 258
LEU A  12
 None
 0.76A 2eilP-2otnA:
undetectable
2eilW-2otnA:
undetectable		 2eilP-2otnA:
21.78
2eilW-2otnA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1n SKP1-LIKE PROTEIN 1A
TRANSPORT INHIBITOR
RESPONSE 1 PROTEIN

(Arabidopsis
thaliana;
Arabidopsis
thaliana) 		PF01466
(Skp1)
PF03931
(Skp1_POZ)
PF12937
(F-box-like) 		4 PHE A  99
PHE B   9
LEU B  14
PHE B  18
 None
 0.94A 2eilP-2p1nA:
undetectable
2eilW-2p1nA:
undetectable		 2eilP-2p1nA:
18.58
2eilW-2p1nA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p25 GLYOXALASE FAMILY
PROTEIN

(Enterococcus
faecalis) 		PF00903
(Glyoxalase) 		4 LEU A 124
PHE A 114
LEU A  91
PHE A  90
 None
 0.90A 2eilP-2p25A:
undetectable
2eilW-2p25A:
undetectable		 2eilP-2p25A:
17.87
2eilW-2p25A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6v TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 4

(Homo sapiens) 		PF07531
(TAFH) 		4 LEU A 622
GLN A 624
PHE A 636
LEU A 640
 None
 0.96A 2eilP-2p6vA:
undetectable
2eilW-2p6vA:
undetectable		 2eilP-2p6vA:
18.34
2eilW-2p6vA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pn1 CARBAMOYLPHOSPHATE
SYNTHASE LARGE
SUBUNIT

(Exiguobacterium
sibiricum) 		PF02655
(ATP-grasp_3) 		4 LEU A 289
GLN A 288
PHE A  21
LEU A  76
 None
 0.82A 2eilP-2pn1A:
undetectable
2eilW-2pn1A:
undetectable		 2eilP-2pn1A:
20.12
2eilW-2pn1A:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q0x UNCHARACTERIZED
PROTEIN

(Trypanosoma
brucei) 		PF08538
(DUF1749) 		4 LEU A 288
GLN A 289
PHE A 290
LEU A  64
 None
 0.90A 2eilP-2q0xA:
undetectable
2eilW-2q0xA:
undetectable		 2eilP-2q0xA:
23.31
2eilW-2q0xA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q2r GLUCOKINASE 1,
PUTATIVE

(Trypanosoma
cruzi) 		PF02685
(Glucokinase) 		5 ARG A  83
LEU A  24
PHE A  26
PHE A  39
LEU A  15
 None
 1.44A 2eilP-2q2rA:
undetectable
2eilW-2q2rA:
undetectable		 2eilP-2q2rA:
21.78
2eilW-2q2rA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qhp FRUCTOKINASE

(Bacteroides
thetaiotaomicron) 		PF00294
(PfkB) 		4 LYS A 175
LEU A 174
PHE A 168
LEU A 202
 None
None
EDO  A 298 ( 4.9A)
EDO  A 298 (-4.9A)
 0.97A 2eilP-2qhpA:
undetectable
2eilW-2qhpA:
undetectable		 2eilP-2qhpA:
21.57
2eilW-2qhpA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qp2 UNKNOWN PROTEIN

(Photorhabdus
laumondii) 		PF01823
(MACPF) 		5 LYS A 335
LEU A 338
PHE A 342
PHE A 195
LEU A 194
 None
 1.32A 2eilP-2qp2A:
undetectable
2eilW-2qp2A:
undetectable		 2eilP-2qp2A:
18.59
2eilW-2qp2A:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qua EXTRACELLULAR LIPASE

(Serratia
marcescens) 		no annotation 5 LEU A 588
GLN A 594
PHE A 565
LEU A 563
PHE A 557
 None
 1.47A 2eilP-2quaA:
undetectable
2eilW-2quaA:
undetectable		 2eilP-2quaA:
17.87
2eilW-2quaA:
6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2riu 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE

(Candida
albicans) 		PF00926
(DHBP_synthase) 		4 LEU A 113
PHE A  93
PHE A 123
LEU A  70
 None
 0.96A 2eilP-2riuA:
undetectable
2eilW-2riuA:
undetectable		 2eilP-2riuA:
21.66
2eilW-2riuA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2toh TYROSINE
3-MONOOXYGENASE

(Rattus
norvegicus) 		PF00351
(Biopterin_H) 		5 GLN A 347
PHE A 348
PHE A 345
LEU A 340
PHE A 309
 None
None
None
None
MTY  A 300 ( 3.9A)
 1.40A 2eilP-2tohA:
undetectable
2eilW-2tohA:
undetectable		 2eilP-2tohA:
21.19
2eilW-2tohA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uur COLLAGEN ALPHA-1(IX)
CHAIN

(Homo sapiens) 		no annotation 5 LEU A 212
PHE A  94
PHE A 210
LEU A 197
PHE A  40
 None
 1.49A 2eilP-2uurA:
undetectable
2eilW-2uurA:
undetectable		 2eilP-2uurA:
17.41
2eilW-2uurA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uxo HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR

(Pseudomonas
putida) 		PF00440
(TetR_N)
PF08361
(TetR_C_2) 		4 ARG A  90
LYS A  91
LEU A  94
GLN A  95
 None
 0.93A 2eilP-2uxoA:
undetectable
2eilW-2uxoA:
undetectable		 2eilP-2uxoA:
21.16
2eilW-2uxoA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wrd HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 LYS A 106
LEU A 109
PHE A 115
LEU A 176
 None
 0.99A 2eilP-2wrdA:
undetectable
2eilW-2wrdA:
undetectable		 2eilP-2wrdA:
18.97
2eilW-2wrdA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xt6 2-OXOGLUTARATE
DECARBOXYLASE

(Mycolicibacterium
smegmatis) 		PF00198
(2-oxoacid_dh)
PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		4 LEU A1146
GLN A1142
PHE A1180
LEU A1184
 None
 0.91A 2eilP-2xt6A:
undetectable
2eilW-2xt6A:
undetectable		 2eilP-2xt6A:
12.79
2eilW-2xt6A:
4.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y0n MALE-SPECIFIC LETHAL
3 HOMOLOG

(Homo sapiens) 		PF05712
(MRG) 		4 LEU A 180
PHE A 499
LEU A 491
PHE A 487
 None
 0.88A 2eilP-2y0nA:
undetectable
2eilW-2y0nA:
undetectable		 2eilP-2y0nA:
18.22
2eilW-2y0nA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yd0 ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 1

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 LEU A 818
PHE A 822
PHE A 832
LEU A 836
 None
 0.78A 2eilP-2yd0A:
undetectable
2eilW-2yd0A:
undetectable		 2eilP-2yd0A:
14.57
2eilW-2yd0A:
4.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfu CARBOHYDRATE BINDING
FAMILY 6

(Ruminiclostridium
thermocellum) 		no annotation 4 GLN A  78
PHE A  77
PHE A 134
LEU A  47
 None
None
None
GOL  A1143 (-4.6A)
 0.91A 2eilP-2yfuA:
undetectable
2eilW-2yfuA:
undetectable		 2eilP-2yfuA:
19.85
2eilW-2yfuA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yok EXOGLUCANASE 1

(Trichoderma
harzianum) 		PF00840
(Glyco_hydro_7) 		4 LYS A 323
GLN A 325
PHE A 286
LEU A 295
 None
 0.96A 2eilP-2yokA:
undetectable
2eilW-2yokA:
undetectable		 2eilP-2yokA:
19.73
2eilW-2yokA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2s RPOE, ECF SIGE

(Rhodobacter
sphaeroides) 		PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4) 		4 ARG A  73
LEU A 176
GLN A 178
LEU A 103
 None
 0.98A 2eilP-2z2sA:
undetectable
2eilW-2z2sA:
undetectable		 2eilP-2z2sA:
18.66
2eilW-2z2sA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zou SPONDIN-1

(Homo sapiens) 		PF02014
(Reeler) 		5 LEU A 177
GLN A 172
PHE A 171
LEU A  82
PHE A  90
 EDO  A   6 (-3.8A)
EDO  A   6 (-4.9A)
None
None
None
 1.31A 2eilP-2zouA:
undetectable
2eilW-2zouA:
undetectable		 2eilP-2zouA:
15.85
2eilW-2zouA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxx DNA REPLICATION
FACTOR CDT1

(Mus musculus) 		PF08839
(CDT1) 		4 LEU C 199
GLN C 191
LEU C 314
PHE C 310
 None
 0.95A 2eilP-2zxxC:
undetectable
2eilW-2zxxC:
undetectable		 2eilP-2zxxC:
20.21
2eilW-2zxxC:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ail 303AA LONG
HYPOTHETICAL
ESTERASE

(Sulfurisphaera
tokodaii) 		PF07859
(Abhydrolase_3) 		4 ARG A 200
GLN A 208
PHE A 182
LEU A 184
 None
None
MRD  A 305 (-4.4A)
None
 0.99A 2eilP-3ailA:
undetectable
2eilW-3ailA:
undetectable		 2eilP-3ailA:
20.54
2eilW-3ailA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ay5 CYCLIN-D1-BINDING
PROTEIN 1

(Homo sapiens) 		PF13324
(GCIP) 		4 GLN A 161
PHE A  99
LEU A  56
PHE A  52
 None
 0.96A 2eilP-3ay5A:
4.8
2eilW-3ay5A:
undetectable		 2eilP-3ay5A:
21.94
2eilW-3ay5A:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b86 GENERAL
ODORANT-BINDING
PROTEIN LUSH

(Drosophila
melanogaster) 		PF01395
(PBP_GOBP) 		4 LEU A  44
PHE A  21
LEU A  31
PHE A  36
 None
 0.99A 2eilP-3b86A:
undetectable
2eilW-3b86A:
undetectable		 2eilP-3b86A:
17.60
2eilW-3b86A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ba3 PYRIDOXAMINE
5'-PHOSPHATE
OXIDASE-LIKE PROTEIN

(Lactobacillus
plantarum) 		no annotation 5 LEU A 123
GLN A  87
PHE A 121
PHE A  45
LEU A  18
 None
 0.91A 2eilP-3ba3A:
undetectable
2eilW-3ba3A:
undetectable		 2eilP-3ba3A:
21.19
2eilW-3ba3A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bho CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
SUBUNIT 5

(Homo sapiens) 		PF13869
(NUDIX_2) 		5 LYS A 192
LEU A  97
GLN A  98
LEU A 129
PHE A 185
 None
 1.36A 2eilP-3bhoA:
undetectable
2eilW-3bhoA:
undetectable		 2eilP-3bhoA:
19.00
2eilW-3bhoA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3buj CALO2

(Micromonospora
echinospora) 		PF00067
(p450) 		4 ARG A 260
LEU A 256
GLN A 255
LEU A 366
 None
 0.99A 2eilP-3bujA:
undetectable
2eilW-3bujA:
undetectable		 2eilP-3bujA:
18.05
2eilW-3bujA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c9b VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 75

(Saccharomyces
cerevisiae) 		PF00956
(NAP) 		4 LYS A  59
LEU A  62
PHE A  68
PHE A 107
 None
 0.95A 2eilP-3c9bA:
undetectable
2eilW-3c9bA:
undetectable		 2eilP-3c9bA:
17.54
2eilW-3c9bA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cr8 SULFATE
ADENYLYLTRANSFERASE,
ADENYLYLSULFATE
KINASE

(Thiobacillus
denitrificans) 		PF01583
(APS_kinase)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 LEU A  74
GLN A  73
PHE A  79
LEU A  56
 None
 0.91A 2eilP-3cr8A:
undetectable
2eilW-3cr8A:
undetectable		 2eilP-3cr8A:
20.53
2eilW-3cr8A:
6.16