SIMILAR PATTERNS OF AMINO ACIDS FOR 2EIK_W_CHDW1060

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aih HP1 INTEGRASE

(Haemophilus
virus HP1) 		PF00589
(Phage_integrase) 		4 ILE A 239
LEU A 243
THR A 215
LEU A 214
 None
None
SO4  A 109 (-4.1A)
None
 0.88A 2eikN-1aihA:
0.0
2eikW-1aihA:
0.0		 2eikN-1aihA:
15.90
2eikW-1aihA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bsf THYMIDYLATE SYNTHASE
A

(Bacillus
subtilis) 		PF00303
(Thymidylat_synt) 		4 ILE A  12
LEU A 231
THR A  59
LEU A  58
 None
 0.93A 2eikN-1bsfA:
undetectable
2eikW-1bsfA:
undetectable		 2eikN-1bsfA:
18.60
2eikW-1bsfA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flo FLP RECOMBINASE

(Saccharomyces
cerevisiae) 		PF03930
(Flp_N)
PF05202
(Flp_C) 		4 ILE A 350
MET A 311
THR A 312
LEU A 315
 None
 0.83A 2eikN-1floA:
0.3
2eikW-1floA:
0.0		 2eikN-1floA:
21.78
2eikW-1floA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl6 ATPASE

(Escherichia
coli) 		PF10412
(TrwB_AAD_bind) 		4 ILE A 355
LEU A 358
ARG A 380
LEU A 371
 None
 0.89A 2eikN-1gl6A:
undetectable
2eikW-1gl6A:
0.0		 2eikN-1gl6A:
21.30
2eikW-1gl6A:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus 1) 		PF00078
(RVT_1) 		4 LEU A 109
MET A 164
THR A 165
LEU A 168
 None
 0.70A 2eikN-1harA:
undetectable
2eikW-1harA:
0.0		 2eikN-1harA:
18.00
2eikW-1harA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jed SULFATE
ADENYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 LEU A  49
ARG A  40
THR A  38
LEU A  37
 None
 0.88A 2eikN-1jedA:
0.0
2eikW-1jedA:
0.0		 2eikN-1jedA:
21.17
2eikW-1jedA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01063
(Aminotran_4) 		4 ILE A 332
MET A 293
THR A 292
LEU A 235
 None
 0.77A 2eikN-1kt8A:
0.0
2eikW-1kt8A:
0.0		 2eikN-1kt8A:
22.71
2eikW-1kt8A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lb4 TNF
RECEPTOR-ASSOCIATED
FACTOR 6

(Homo sapiens) 		no annotation 4 LEU A 389
PHE A 380
THR A 433
LEU A 432
 None
 0.94A 2eikN-1lb4A:
undetectable
2eikW-1lb4A:
undetectable		 2eikN-1lb4A:
14.34
2eikW-1lb4A:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6x ATP:SULFATE
ADENYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 LEU A  49
ARG A  40
THR A  38
LEU A  37
 None
 0.88A 2eikN-1r6xA:
0.0
2eikW-1r6xA:
0.0		 2eikN-1r6xA:
21.48
2eikW-1r6xA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rtg HUMAN GELATINASE A

(Homo sapiens) 		PF00045
(Hemopexin) 		4 ILE A 478
PHE A 632
ARG A 500
LEU A 623
 None
 0.91A 2eikN-1rtgA:
undetectable
2eikW-1rtgA:
undetectable		 2eikN-1rtgA:
17.56
2eikW-1rtgA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ska 3-PHYTASE A

(Aspergillus
fumigatus) 		PF00328
(His_Phos_2) 		4 LEU A 261
PHE A 262
THR A 230
LEU A 229
 None
 0.76A 2eikN-1skaA:
0.0
2eikW-1skaA:
undetectable		 2eikN-1skaA:
19.89
2eikW-1skaA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1su1 HYPOTHETICAL PROTEIN
YFCE

(Escherichia
coli) 		PF12850
(Metallophos_2) 		4 ILE A  34
PHE A  85
ARG A  59
LEU A  39
 None
 0.93A 2eikN-1su1A:
undetectable
2eikW-1su1A:
undetectable		 2eikN-1su1A:
19.04
2eikW-1su1A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zv4 REGULATOR OF
G-PROTEIN SIGNALING
17

(Homo sapiens) 		PF00615
(RGS) 		4 ILE X 178
LEU X 181
ARG X  95
LEU X 102
 None
 0.88A 2eikN-1zv4X:
0.0
2eikW-1zv4X:
undetectable		 2eikN-1zv4X:
13.67
2eikW-1zv4X:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2idc ANTI-SILENCING
PROTEIN 1 AND
HISTONE H3 CHIMERA

(Saccharomyces
cerevisiae) 		PF04729
(ASF1_hist_chap) 		4 ILE A   9
ARG A 108
THR A  43
LEU A  42
 None
 0.88A 2eikN-2idcA:
undetectable
2eikW-2idcA:
undetectable		 2eikN-2idcA:
13.97
2eikW-2idcA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2la7 UNCHARACTERIZED
PROTEIN

(Paraburkholderia
xenovorans) 		PF03724
(META) 		4 LEU A 112
ARG A 117
THR A 137
LEU A 138
 None
 0.85A 2eikN-2la7A:
undetectable
2eikW-2la7A:
undetectable		 2eikN-2la7A:
14.14
2eikW-2la7A:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6q VARIABLE LYMPHOCYTE
RECEPTOR A

(Eptatretus
burgeri) 		PF13855
(LRR_8) 		4 ILE A  53
PHE A  79
THR A  97
LEU A  95
 None
 0.91A 2eikN-2o6qA:
undetectable
2eikW-2o6qA:
undetectable		 2eikN-2o6qA:
18.29
2eikW-2o6qA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0d RHO
GTPASE-ACTIVATING
PROTEIN 9

(Homo sapiens) 		PF00169
(PH) 		4 ILE A 405
LEU A 390
THR A 353
LEU A 352
 None
 0.76A 2eikN-2p0dA:
undetectable
2eikW-2p0dA:
undetectable		 2eikN-2p0dA:
12.67
2eikW-2p0dA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q7s N-FORMYLGLUTAMATE
AMIDOHYDROLASE

(Cupriavidus
pinatubonensis) 		PF05013
(FGase) 		4 ILE A 250
PHE A 192
ARG A 272
THR A 275
 None
 0.95A 2eikN-2q7sA:
undetectable
2eikW-2q7sA:
undetectable		 2eikN-2q7sA:
19.19
2eikW-2q7sA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqo NEUROPILIN-2

(Homo sapiens) 		PF00431
(CUB)
PF00754
(F5_F8_type_C) 		4 ILE A 566
PHE A 563
ARG A 572
LEU A 492
 None
 0.93A 2eikN-2qqoA:
undetectable
2eikW-2qqoA:
undetectable		 2eikN-2qqoA:
20.44
2eikW-2qqoA:
8.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvf EXOPOLYGALACTURONASE

(Yersinia
enterocolitica) 		PF00295
(Glyco_hydro_28)
PF12708
(Pectate_lyase_3) 		4 PHE A 347
MET A 334
THR A 335
LEU A 336
 None
 0.85A 2eikN-2uvfA:
undetectable
2eikW-2uvfA:
undetectable		 2eikN-2uvfA:
22.56
2eikW-2uvfA:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ws9 P1

(Equine rhinitis
A virus) 		no annotation 4 LEU 1  84
PHE 1 156
THR 1 198
LEU 1 197
 None
 0.87A 2eikN-2ws91:
undetectable
2eikW-2ws91:
undetectable		 2eikN-2ws91:
19.07
2eikW-2ws91:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wy0 ANGIOTENSINOGEN

(Mus musculus) 		PF00079
(Serpin) 		4 LEU C 309
ARG C 345
THR C 423
LEU C 424
 None
 0.74A 2eikN-2wy0C:
undetectable
2eikW-2wy0C:
undetectable		 2eikN-2wy0C:
21.21
2eikW-2wy0C:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3c TOXIC EXTRACELLULAR
ENDOPEPTIDASE

(Aeromonas
salmonicida) 		PF14521
(Aspzincin_M35) 		4 LEU A  67
PHE A  68
THR A  43
LEU A  44
 None
 0.84A 2eikN-2x3cA:
0.5
2eikW-2x3cA:
undetectable		 2eikN-2x3cA:
20.64
2eikW-2x3cA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y69 CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1

(Bos taurus) 		PF02238
(COX7a) 		5 TYR J  32
ARG J  33
MET J  36
THR J  37
LEU J  40
 None
 0.48A 2eikN-2y69J:
undetectable
2eikW-2y69J:
8.0		 2eikN-2y69J:
10.31
2eikW-2y69J:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		4 LEU B 428
ARG B 441
THR B 436
LEU B 435
 None
 0.94A 2eikN-2z7xB:
undetectable
2eikW-2z7xB:
undetectable		 2eikN-2z7xB:
23.01
2eikW-2z7xB:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ze0 ALPHA-GLUCOSIDASE

(Geobacillus sp.
HTA-462) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 ILE A 193
LEU A  97
PHE A 196
MET A 184
 None
 0.77A 2eikN-2ze0A:
undetectable
2eikW-2ze0A:
undetectable		 2eikN-2ze0A:
19.59
2eikW-2ze0A:
7.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zts PUTATIVE
UNCHARACTERIZED
PROTEIN PH0186

(Pyrococcus
horikoshii) 		PF06745
(ATPase) 		4 ILE A 127
PHE A 123
THR A 178
LEU A 177
 None
 0.74A 2eikN-2ztsA:
undetectable
2eikW-2ztsA:
undetectable		 2eikN-2ztsA:
17.81
2eikW-2ztsA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4

(Homo sapiens) 		PF00168
(C2) 		5 PHE A 189
ARG A 124
MET A 248
THR A 249
LEU A 213
 None
 1.37A 2eikN-3b7yA:
undetectable
2eikW-3b7yA:
undetectable		 2eikN-3b7yA:
13.39
2eikW-3b7yA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4

(Homo sapiens) 		PF00168
(C2) 		5 PHE A 229
ARG A 124
MET A 248
THR A 249
LEU A 213
 None
 1.50A 2eikN-3b7yA:
undetectable
2eikW-3b7yA:
undetectable		 2eikN-3b7yA:
13.39
2eikW-3b7yA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bn1 PEROSAMINE
SYNTHETASE

(Caulobacter
vibrioides) 		PF01041
(DegT_DnrJ_EryC1) 		4 ILE A 312
TYR A 261
THR A 289
LEU A 346
 None
 0.92A 2eikN-3bn1A:
undetectable
2eikW-3bn1A:
undetectable		 2eikN-3bn1A:
21.12
2eikW-3bn1A:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dby UNCHARACTERIZED
PROTEIN

(Bacillus cereus) 		PF11155
(DUF2935) 		4 LEU A  53
PHE A  50
ARG A  77
LEU A 115
 None
 0.84A 2eikN-3dbyA:
1.8
2eikW-3dbyA:
undetectable		 2eikN-3dbyA:
17.09
2eikW-3dbyA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dcp HISTIDINOL-PHOSPHATA
SE

(Listeria
monocytogenes) 		PF02811
(PHP)
PF13263
(PHP_C) 		4 LEU A  30
PHE A  32
TYR A 255
THR A 271
 None
 0.77A 2eikN-3dcpA:
undetectable
2eikW-3dcpA:
undetectable		 2eikN-3dcpA:
19.37
2eikW-3dcpA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg4 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 ILE A 462
ARG A 397
THR A 395
LEU A 410
 None
 0.85A 2eikN-3fg4A:
1.9
2eikW-3fg4A:
undetectable		 2eikN-3fg4A:
20.56
2eikW-3fg4A:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fss HISTONE CHAPERONE
RTT106

(Saccharomyces
cerevisiae) 		PF08512
(Rtt106) 		4 ILE A 200
MET A 158
THR A 159
LEU A 160
 None
 0.91A 2eikN-3fssA:
undetectable
2eikW-3fssA:
undetectable		 2eikN-3fssA:
19.04
2eikW-3fssA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gju PUTATIVE
AMINOTRANSFERASE

(Mesorhizobium
japonicum) 		PF00202
(Aminotran_3) 		4 ILE A 131
MET A 159
THR A 160
LEU A 163
 None
 0.85A 2eikN-3gjuA:
undetectable
2eikW-3gjuA:
undetectable		 2eikN-3gjuA:
22.26
2eikW-3gjuA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hi8 PROLIFERATING CELL
NUCLEAR ANTIGEN PCNA

(Haloferax
volcanii) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 LEU A  15
ARG A  37
THR A  50
LEU A  51
 None
 0.88A 2eikN-3hi8A:
undetectable
2eikW-3hi8A:
undetectable		 2eikN-3hi8A:
20.53
2eikW-3hi8A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 5

(Homo sapiens) 		PF00443
(UCH)
PF00627
(UBA)
PF02148
(zf-UBP) 		4 ILE A 599
LEU A 602
PHE A 562
LEU A 489
 None
 0.95A 2eikN-3ihpA:
undetectable
2eikW-3ihpA:
undetectable		 2eikN-3ihpA:
18.99
2eikW-3ihpA:
6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4p CAPSID PROTEIN VP1

(Adeno-associated
virus) 		PF00740
(Parvo_coat) 		4 ILE A 374
LEU A 249
ARG A 245
LEU A 317
 None
 0.86A 2eikN-3j4pA:
undetectable
2eikW-3j4pA:
undetectable		 2eikN-3j4pA:
22.36
2eikW-3j4pA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF10

(Schizosaccharomyces
pombe) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF16004
(EFTUD2) 		4 ILE B 544
ARG B 509
MET B 490
LEU B 488
 None
 0.95A 2eikN-3jb9B:
undetectable
2eikW-3jb9B:
undetectable		 2eikN-3jb9B:
17.37
2eikW-3jb9B:
5.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE

(Cupriavidus
pinatubonensis) 		PF00465
(Fe-ADH) 		4 ILE A 343
LEU A 346
ARG A 322
LEU A 248
 None
 0.85A 2eikN-3jzdA:
undetectable
2eikW-3jzdA:
undetectable		 2eikN-3jzdA:
22.15
2eikW-3jzdA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k13 5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE

(Bacteroides
thetaiotaomicron) 		PF00809
(Pterin_bind) 		4 ARG A 407
MET A 410
THR A 411
LEU A 414
 None
 0.65A 2eikN-3k13A:
0.4
2eikW-3k13A:
undetectable		 2eikN-3k13A:
20.20
2eikW-3k13A:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3muu STRUCTURAL
POLYPROTEIN

(Sindbis virus) 		PF00943
(Alpha_E2_glycop)
PF01589
(Alpha_E1_glycop) 		4 ILE A 283
ARG A 298
THR A 296
LEU A 295
 None
 0.74A 2eikN-3muuA:
undetectable
2eikW-3muuA:
undetectable		 2eikN-3muuA:
21.45
2eikW-3muuA:
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ng9 CAPSID PROTEIN

(Adeno-associated
dependoparvovirus
A) 		PF00740
(Parvo_coat) 		4 ILE A 373
LEU A 249
ARG A 245
LEU A 316
 None
 0.92A 2eikN-3ng9A:
undetectable
2eikW-3ng9A:
undetectable		 2eikN-3ng9A:
21.77
2eikW-3ng9A:
7.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nws CELL DIVISION
CONTROL PROTEIN 13

(Saccharomyces
cerevisiae) 		PF16853
(CDC13_N) 		4 ILE A  89
ARG A 116
THR A  42
LEU A  41
 None
 0.86A 2eikN-3nwsA:
undetectable
2eikW-3nwsA:
undetectable		 2eikN-3nwsA:
15.67
2eikW-3nwsA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pf2 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF16569
(GramPos_pilinBB)
PF16570
(GramPos_pilinD3) 		4 ILE A 236
LEU A 240
THR A 270
LEU A 271
 None
 0.70A 2eikN-3pf2A:
undetectable
2eikW-3pf2A:
undetectable		 2eikN-3pf2A:
18.65
2eikW-3pf2A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q0x CENTRIOLE PROTEIN

(Chlamydomonas
reinhardtii) 		PF16531
(SAS-6_N) 		4 LEU A 153
PHE A 155
ARG A  48
LEU A  63
 None
 0.75A 2eikN-3q0xA:
undetectable
2eikW-3q0xA:
2.9		 2eikN-3q0xA:
16.90
2eikW-3q0xA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u15 PROTEIN MDM4

(Homo sapiens) 		PF02201
(SWIB) 		4 ILE A  36
ARG A  87
MET A 101
LEU A 102
 None
 0.84A 2eikN-3u15A:
undetectable
2eikW-3u15A:
undetectable		 2eikN-3u15A:
11.22
2eikW-3u15A:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uv0 MUTATOR 2, ISOFORM B

(Drosophila
melanogaster) 		no annotation 4 ILE A  24
PHE A  89
ARG A  55
LEU A  16
 None
 0.88A 2eikN-3uv0A:
undetectable
2eikW-3uv0A:
undetectable		 2eikN-3uv0A:
10.43
2eikW-3uv0A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wa8 CRISPR-ASSOCIATED
PROTEIN, CSE2 FAMILY

(Meiothermus
ruber) 		PF09485
(CRISPR_Cse2) 		4 LEU A  68
ARG A 164
THR A 105
LEU A 106
 None
 0.81A 2eikN-3wa8A:
undetectable
2eikW-3wa8A:
undetectable		 2eikN-3wa8A:
13.36
2eikW-3wa8A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8c GLUCOSE-REPRESSIBLE
ALCOHOL
DEHYDROGENASE
TRANSCRIPTIONAL
EFFECTOR

(Saccharomyces
cerevisiae) 		PF03372
(Exo_endo_phos)
PF13855
(LRR_8) 		4 ILE D 376
LEU D 399
THR D 370
LEU D 392
 None
 0.84A 2eikN-4b8cD:
undetectable
2eikW-4b8cD:
undetectable		 2eikN-4b8cD:
21.05
2eikW-4b8cD:
6.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4biz SENSOR PROTEIN CPXA

(Escherichia
coli) 		PF00512
(HisKA)
PF00672
(HAMP)
PF02518
(HATPase_c) 		4 ILE A 399
LEU A 421
PHE A 400
THR A 383
 ADP  A 501 (-4.4A)
ADP  A 501 (-3.8A)
None
None
 0.88A 2eikN-4bizA:
2.3
2eikW-4bizA:
undetectable		 2eikN-4bizA:
17.40
2eikW-4bizA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bob ERPP PROTEIN

(Borreliella
burgdorferi) 		PF02471
(OspE) 		4 PHE A  78
MET A  92
THR A  93
LEU A 160
 None
 0.72A 2eikN-4bobA:
undetectable
2eikW-4bobA:
undetectable		 2eikN-4bobA:
15.65
2eikW-4bobA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxm ERPC

(Borreliella
burgdorferi) 		PF02471
(OspE) 		4 PHE A  73
MET A  87
THR A  88
LEU A 153
 None
 0.75A 2eikN-4bxmA:
undetectable
2eikW-4bxmA:
undetectable		 2eikN-4bxmA:
15.42
2eikW-4bxmA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c00 TRANSLOCATION AND
ASSEMBLY MODULE TAMA

(Escherichia
coli) 		PF01103
(Bac_surface_Ag)
PF07244
(POTRA)
PF17243
(POTRA_TamA_1) 		4 ILE A  79
PHE A  81
ARG A  60
LEU A  43
 None
 0.92A 2eikN-4c00A:
undetectable
2eikW-4c00A:
undetectable		 2eikN-4c00A:
20.17
2eikW-4c00A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9l 20.1 ANTI-BTN3A1
ANTIBODY FRAGMENT

(Mus musculus) 		no annotation 4 LEU D 142
ARG D 171
THR D 218
LEU D 217
 None
 0.91A 2eikN-4f9lD:
undetectable
2eikW-4f9lD:
undetectable		 2eikN-4f9lD:
18.81
2eikW-4f9lD:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fha DIHYDRODIPICOLINATE
SYNTHASE

(Streptococcus
pneumoniae) 		PF00701
(DHDPS) 		4 ILE A 164
PHE A 187
THR A 151
LEU A 150
 None
 0.92A 2eikN-4fhaA:
undetectable
2eikW-4fhaA:
undetectable		 2eikN-4fhaA:
21.36
2eikW-4fhaA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fi9 SUN
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF07738
(Sad1_UNC) 		4 ILE A 648
PHE A 679
ARG A 710
LEU A 615
 None
 0.86A 2eikN-4fi9A:
undetectable
2eikW-4fi9A:
undetectable		 2eikN-4fi9A:
17.12
2eikW-4fi9A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfj TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24)
PF14520
(HHH_5) 		4 ILE A 285
ARG A 276
THR A 274
LEU A 273
 None
 0.95A 2eikN-4gfjA:
1.8
2eikW-4gfjA:
undetectable		 2eikN-4gfjA:
20.06
2eikW-4gfjA:
5.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htf S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE

(Escherichia
coli) 		PF13847
(Methyltransf_31) 		4 ILE B 116
LEU B 135
THR B 111
LEU B 109
 None
 0.90A 2eikN-4htfB:
undetectable
2eikW-4htfB:
undetectable		 2eikN-4htfB:
18.97
2eikW-4htfB:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j38 OUTER SURFACE
PROTEIN E

(Borreliella
burgdorferi) 		PF02471
(OspE) 		4 PHE A  86
MET A 100
THR A 101
LEU A 166
 None
 0.75A 2eikN-4j38A:
undetectable
2eikW-4j38A:
undetectable		 2eikN-4j38A:
13.32
2eikW-4j38A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kem MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Azospirillum
lipoferum) 		PF13378
(MR_MLE_C) 		4 LEU A 275
ARG A 303
MET A 307
LEU A 308
 None
 0.84A 2eikN-4kemA:
undetectable
2eikW-4kemA:
undetectable		 2eikN-4kemA:
21.75
2eikW-4kemA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l37 ARYLPHORIN

(Bombyx mori) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 ILE B 512
LEU B 537
PHE B 558
LEU B 452
 None
 0.88A 2eikN-4l37B:
undetectable
2eikW-4l37B:
undetectable		 2eikN-4l37B:
18.83
2eikW-4l37B:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m1a HYPOTHETICAL PROTEIN

(Sebaldella
termitidis) 		PF08921
(DUF1904) 		4 ILE A  73
PHE A  77
ARG A   5
THR A  37
 None
 0.77A 2eikN-4m1aA:
undetectable
2eikW-4m1aA:
undetectable		 2eikN-4m1aA:
12.03
2eikW-4m1aA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4om9 SERINE PROTEASE PET

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		4 ILE A 662
LEU A 683
THR A 674
LEU A 672
 None
 0.72A 2eikN-4om9A:
undetectable
2eikW-4om9A:
undetectable		 2eikN-4om9A:
19.71
2eikW-4om9A:
5.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pk1 CHIMERA PROTEIN OF
OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTORS BAMA AND
BAMB

(Escherichia
coli) 		PF07244
(POTRA)
PF13360
(PQQ_2) 		4 ILE A1349
PHE A1356
ARG A1304
LEU A1327
 None
 0.92A 2eikN-4pk1A:
undetectable
2eikW-4pk1A:
undetectable		 2eikN-4pk1A:
21.54
2eikW-4pk1A:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r58 LEUCINE RICH REPEAT
PROTEIN

(synthetic
construct) 		PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6) 		4 ILE A  22
PHE A  18
THR A  67
LEU A  65
 None
 0.94A 2eikN-4r58A:
undetectable
2eikW-4r58A:
undetectable		 2eikN-4r58A:
18.29
2eikW-4r58A:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rrp ANTIGEN ASF1P

(Saccharomyces
cerevisiae) 		PF04729
(ASF1_hist_chap) 		4 ILE M   9
ARG M 108
THR M  43
LEU M  42
 None
 0.74A 2eikN-4rrpM:
undetectable
2eikW-4rrpM:
undetectable		 2eikN-4rrpM:
13.87
2eikW-4rrpM:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rwt LEIOMODIN-2

(Homo sapiens) 		no annotation 4 ARG C 309
MET C 312
THR C 313
LEU C 316
 None
 0.84A 2eikN-4rwtC:
undetectable
2eikW-4rwtC:
undetectable		 2eikN-4rwtC:
19.44
2eikW-4rwtC:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8p TALIN-1
AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER
1-INTERACTING
PROTEIN

(Mus musculus;
Mus musculus) 		no annotation
no annotation 		4 LEU B  15
PHE B  12
THR A1562
LEU A1565
 EDO  A1701 ( 4.8A)
None
None
None
 0.93A 2eikN-4w8pB:
undetectable
2eikW-4w8pB:
undetectable		 2eikN-4w8pB:
6.75
2eikW-4w8pB:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yk6 ADENOMATOUS
POLYPOSIS COLI
PROTEIN

(Homo sapiens) 		PF00514
(Arm)
PF16629
(Arm_APC_u3) 		4 LEU A 572
ARG A 527
THR A 562
LEU A 563
 None
 0.95A 2eikN-4yk6A:
2.3
2eikW-4yk6A:
undetectable		 2eikN-4yk6A:
18.86
2eikW-4yk6A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A

(Oryctolagus
cuniculus) 		PF01399
(PCI) 		4 ILE A 484
LEU A 491
PHE A 452
LEU A 440
 None
 0.92A 2eikN-5a5tA:
undetectable
2eikW-5a5tA:
undetectable		 2eikN-5a5tA:
13.37
2eikW-5a5tA:
5.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aeo R. EQUI VAPG PROTEIN

(Rhodococcus
hoagii) 		PF05526
(R_equi_Vir) 		4 ILE A 132
LEU A 112
THR A  61
LEU A  60
 None
 0.78A 2eikN-5aeoA:
undetectable
2eikW-5aeoA:
undetectable		 2eikN-5aeoA:
15.81
2eikW-5aeoA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF17137
(DUF5110) 		4 PHE A 186
ARG A 109
THR A  99
LEU A  98
 None
 0.85A 2eikN-5dkxA:
undetectable
2eikW-5dkxA:
undetectable		 2eikN-5dkxA:
18.91
2eikW-5dkxA:
5.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dtc RIBOSOME BIOGENESIS
PROTEIN YTM1

(Saccharomyces
cerevisiae) 		PF08154
(NLE) 		4 ILE A  42
PHE A  12
ARG A  36
LEU A  68
 None
 0.91A 2eikN-5dtcA:
undetectable
2eikW-5dtcA:
undetectable		 2eikN-5dtcA:
9.94
2eikW-5dtcA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ed8 MKIAA0668 PROTEIN

(Mus musculus) 		PF07738
(Sad1_UNC) 		4 ILE A 630
PHE A 661
ARG A 692
LEU A 597
 None
 0.88A 2eikN-5ed8A:
undetectable
2eikW-5ed8A:
undetectable		 2eikN-5ed8A:
19.08
2eikW-5ed8A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5edj FRPC OPERON PROTEIN

(Neisseria
meningitidis) 		PF06901
(FrpC) 		4 ILE A  72
PHE A  63
ARG A  79
THR A  81
 None
 0.86A 2eikN-5edjA:
undetectable
2eikW-5edjA:
undetectable		 2eikN-5edjA:
16.42
2eikW-5edjA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzy (R)-2-HALOACID
DEHALOGENASE

(Pseudomonas
putida) 		PF10778
(DehI) 		4 ILE A 126
PHE A 127
ARG A 211
MET A 176
 None
 0.88A 2eikN-5gzyA:
0.5
2eikW-5gzyA:
undetectable		 2eikN-5gzyA:
20.49
2eikW-5gzyA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h2t TREHALOSE SYNTHASE

(Thermomonospora
curvata) 		no annotation 4 ILE A 305
LEU A 493
ARG A 298
LEU A 377
 None
 0.92A 2eikN-5h2tA:
undetectable
2eikW-5h2tA:
undetectable		 2eikN-5h2tA:
20.56
2eikW-5h2tA:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdh TOLL-LIKE RECEPTOR 8

(Homo sapiens) 		PF13855
(LRR_8) 		4 ILE A 671
LEU A 695
THR A 667
LEU A 690
 None
 0.84A 2eikN-5hdhA:
undetectable
2eikW-5hdhA:
undetectable		 2eikN-5hdhA:
19.75
2eikW-5hdhA:
6.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2q EF-HAND
DOMAIN-CONTAINING
PROTEIN D2

(Homo sapiens) 		PF13405
(EF-hand_6) 		4 ILE A 156
LEU A 171
MET A 121
LEU A 117
 None
 0.82A 2eikN-5i2qA:
undetectable
2eikW-5i2qA:
undetectable		 2eikN-5i2qA:
11.61
2eikW-5i2qA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE

(Thermotoga
neapolitana) 		PF00232
(Glyco_hydro_1) 		4 ILE A 253
LEU A 250
ARG A 197
LEU A 165
 None
 0.89A 2eikN-5idiA:
undetectable
2eikW-5idiA:
undetectable		 2eikN-5idiA:
21.38
2eikW-5idiA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 LEU A 928
PHE A 931
THR A 881
LEU A 884
 None
 0.69A 2eikN-5j6sA:
undetectable
2eikW-5j6sA:
undetectable		 2eikN-5j6sA:
20.29
2eikW-5j6sA:
5.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jw7 E3 UBIQUITIN-PROTEIN
LIGASE TRIM56

(Homo sapiens) 		PF13445
(zf-RING_UBOX) 		4 ILE B  23
LEU B  48
THR B  33
LEU B  34
 None
 0.80A 2eikN-5jw7B:
undetectable
2eikW-5jw7B:
undetectable		 2eikN-5jw7B:
10.76
2eikW-5jw7B:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jwf ASP/GLU-SPECIFIC
DIPEPTIDYL-PEPTIDASE

(Porphyromonas
gingivalis) 		PF10459
(Peptidase_S46) 		4 ILE A 703
LEU A 700
THR A  82
LEU A  81
 None
 0.82A 2eikN-5jwfA:
0.6
2eikW-5jwfA:
undetectable		 2eikN-5jwfA:
20.60
2eikW-5jwfA:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli) 		PF01043
(SecA_PP_bind)
PF07517
(SecA_DEAD) 		4 LEU A 286
ARG A 277
THR A 275
LEU A 274
 None
 0.73A 2eikN-5k9tA:
undetectable
2eikW-5k9tA:
undetectable		 2eikN-5k9tA:
21.11
2eikW-5k9tA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqm GLYCOSYL HYDROLASES
FAMILY 2, SUGAR
BINDING DOMAIN

(Bacteroides
thetaiotaomicron) 		PF17132
(Glyco_hydro_106) 		4 ILE A 155
LEU A 158
THR A 370
LEU A 175
 None
 0.77A 2eikN-5mqmA:
undetectable
2eikW-5mqmA:
undetectable		 2eikN-5mqmA:
19.15
2eikW-5mqmA:
4.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbq OUTER SURFACE
PROTEIN E

(Borreliella
burgdorferi) 		no annotation 4 PHE G  86
MET G 100
THR G 101
LEU G 166
 None
 0.79A 2eikN-5nbqG:
undetectable
2eikW-5nbqG:
undetectable		 2eikN-5nbqG:
undetectable
2eikW-5nbqG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqd ARSENITE OXIDASE
LARGE SUBUNIT AIOA
[3FE-4S] CLUSTER,
MO-MOLYBDOPTERIN
COFACTOR-BINDING
ACTIVE SITE

(Rhizobium sp.
NT-26) 		no annotation 4 LEU A 163
ARG A 149
MET A 604
LEU A 600
 None
 0.88A 2eikN-5nqdA:
undetectable
2eikW-5nqdA:
undetectable		 2eikN-5nqdA:
undetectable
2eikW-5nqdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ny0 L. REUTERIS SRRP
BINDING REGION

(Lactobacillus
reuteri) 		no annotation 4 ILE A 427
MET A 477
THR A 476
LEU A 475
 None
 0.78A 2eikN-5ny0A:
undetectable
2eikW-5ny0A:
undetectable		 2eikN-5ny0A:
undetectable
2eikW-5ny0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0l RETICULON-4 RECEPTOR

(Mus musculus) 		no annotation 4 LEU A 112
ARG A  61
THR A  84
LEU A 107
 None
 0.92A 2eikN-5o0lA:
undetectable
2eikW-5o0lA:
undetectable		 2eikN-5o0lA:
20.26
2eikW-5o0lA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqj RNA POLYMERASE II
TRANSCRIPTION FACTOR
B SUBUNIT 1

(Saccharomyces
cerevisiae) 		no annotation 4 LEU 1  60
PHE 1  91
THR 1  28
LEU 1  27
 None
 0.63A 2eikN-5oqj1:
undetectable
2eikW-5oqj1:
undetectable		 2eikN-5oqj1:
undetectable
2eikW-5oqj1:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqm GENERAL
TRANSCRIPTION AND
DNA REPAIR FACTOR
IIH SUBUNIT TFB1

(Saccharomyces
cerevisiae) 		no annotation 4 LEU 1  60
PHE 1  91
THR 1  28
LEU 1  27
 None
 0.67A 2eikN-5oqm1:
undetectable
2eikW-5oqm1:
undetectable		 2eikN-5oqm1:
undetectable
2eikW-5oqm1:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tjt MAJOR CAPSID PROTEIN

(Escherichia
virus T5) 		PF05065
(Phage_capsid) 		4 ILE A 347
MET A 288
THR A 289
LEU A 300
 None
 0.94A 2eikN-5tjtA:
undetectable
2eikW-5tjtA:
undetectable		 2eikN-5tjtA:
21.23
2eikW-5tjtA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpw GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2A

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 ILE B 127
PHE B 147
THR B 300
LEU B 299
 None
 0.84A 2eikN-5tpwB:
undetectable
2eikW-5tpwB:
undetectable		 2eikN-5tpwB:
20.58
2eikW-5tpwB:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vob ENVELOPE
GLYCOPROTEIN UL128

(Human
betaherpesvirus
5) 		no annotation 4 ILE C 109
LEU C 103
THR C  85
LEU C  84
 None
 0.88A 2eikN-5vobC:
undetectable
2eikW-5vobC:
undetectable		 2eikN-5vobC:
14.92
2eikW-5vobC:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wug BETA-GLUCOSIDASE

(Paenibacillus
barengoltzii) 		no annotation 4 LEU A 243
TYR A  76
ARG A  78
LEU A 591
 None
 0.85A 2eikN-5wugA:
undetectable
2eikW-5wugA:
undetectable		 2eikN-5wugA:
undetectable
2eikW-5wugA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xag TUBULIN TYROSINE
LIGASE

(Gallus gallus) 		no annotation 4 ILE F 201
LEU F 221
THR F 278
LEU F 271
 None
 0.79A 2eikN-5xagF:
undetectable
2eikW-5xagF:
undetectable		 2eikN-5xagF:
undetectable
2eikW-5xagF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xe0 GENOME POLYPROTEIN

(Enterovirus D) 		PF00680
(RdRP_1) 		4 ILE A 291
PHE A 194
TYR A  77
LEU A 249
 None
 0.92A 2eikN-5xe0A:
undetectable
2eikW-5xe0A:
undetectable		 2eikN-5xe0A:
20.98
2eikW-5xe0A:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfa NAD-REDUCING
HYDROGENASE

(Hydrogenophilus
thermoluteolus) 		PF01257
(2Fe-2S_thioredx)
PF01512
(Complex1_51K)
PF10589
(NADH_4Fe-4S) 		4 LEU A 538
ARG A 511
THR A 505
LEU A 550
 None
 0.85A 2eikN-5xfaA:
undetectable
2eikW-5xfaA:
undetectable		 2eikN-5xfaA:
22.80
2eikW-5xfaA:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xu1 ABC TRANSPORTER
ATP-BINDING PROTEIN

(Streptococcus
pneumoniae) 		no annotation 4 ILE A  88
LEU A 167
PHE A  90
THR A  59
 None
 0.83A 2eikN-5xu1A:
undetectable
2eikW-5xu1A:
undetectable		 2eikN-5xu1A:
undetectable
2eikW-5xu1A:
undetectable