SIMILAR PATTERNS OF AMINO ACIDS FOR 2EIK_J_CHDJ60_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flo FLP RECOMBINASE

(Saccharomyces
cerevisiae) 		PF03930
(Flp_N)
PF05202
(Flp_C) 		4 ARG A 308
MET A 311
THR A 312
LEU A 315
 None
 0.86A 2eikA-1floA:
0.2
2eikJ-1floA:
0.0		 2eikA-1floA:
21.78
2eikJ-1floA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzk RAC-BETA
SERINE/THREONINE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 LEU A 380
PHE A 408
ARG A 251
MET A 344
 None
 1.03A 2eikA-1gzkA:
0.0
2eikJ-1gzkA:
undetectable		 2eikA-1gzkA:
20.42
2eikJ-1gzkA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus 1) 		PF00078
(RVT_1) 		4 LEU A 109
MET A 164
THR A 165
LEU A 168
 None
 0.67A 2eikA-1harA:
undetectable
2eikJ-1harA:
0.0		 2eikA-1harA:
18.00
2eikJ-1harA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jed SULFATE
ADENYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 LEU A  49
ARG A  40
THR A  38
LEU A  37
 None
 0.80A 2eikA-1jedA:
0.0
2eikJ-1jedA:
0.0		 2eikA-1jedA:
21.17
2eikJ-1jedA:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1khc DNA CYTOSINE-5
METHYLTRANSFERASE
3B2

(Mus musculus) 		PF00855
(PWWP) 		4 TYR A 305
ARG A 306
MET A 309
LEU A 313
 None
 1.04A 2eikA-1khcA:
undetectable
2eikJ-1khcA:
undetectable		 2eikA-1khcA:
13.81
2eikJ-1khcA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lb4 TNF
RECEPTOR-ASSOCIATED
FACTOR 6

(Homo sapiens) 		no annotation 4 LEU A 389
PHE A 380
THR A 433
LEU A 432
 None
 0.93A 2eikA-1lb4A:
undetectable
2eikJ-1lb4A:
0.0		 2eikA-1lb4A:
14.34
2eikJ-1lb4A:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nph GELSOLIN

(Mus musculus) 		PF00626
(Gelsolin) 		4 LEU A 674
PHE A 681
THR A 626
LEU A 630
 None
 1.08A 2eikA-1nphA:
undetectable
2eikJ-1nphA:
0.0		 2eikA-1nphA:
19.58
2eikJ-1nphA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozn RETICULON 4 RECEPTOR

(Homo sapiens) 		PF13855
(LRR_8) 		4 LEU A 112
ARG A  61
THR A  84
LEU A 107
 None
 1.11A 2eikA-1oznA:
undetectable
2eikJ-1oznA:
0.0		 2eikA-1oznA:
19.64
2eikJ-1oznA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6x ATP:SULFATE
ADENYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 LEU A  49
ARG A  40
THR A  38
LEU A  37
 None
 0.81A 2eikA-1r6xA:
0.0
2eikJ-1r6xA:
0.0		 2eikA-1r6xA:
21.48
2eikJ-1r6xA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sdd COAGULATION FACTOR V

(Bos taurus) 		PF00754
(F5_F8_type_C)
PF07732
(Cu-oxidase_3) 		4 LEU B1843
PHE B1859
MET B1833
LEU B1808
 None
 0.94A 2eikA-1sddB:
undetectable
2eikJ-1sddB:
undetectable		 2eikA-1sddB:
20.53
2eikJ-1sddB:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ska 3-PHYTASE A

(Aspergillus
fumigatus) 		PF00328
(His_Phos_2) 		4 LEU A 261
PHE A 262
THR A 230
LEU A 229
 None
 0.74A 2eikA-1skaA:
0.0
2eikJ-1skaA:
undetectable		 2eikA-1skaA:
19.89
2eikJ-1skaA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sr4 CYTOLETHAL
DISTENDING TOXIN
SUBUNIT A

([Haemophilus]
ducreyi) 		PF03498
(CDtoxinA) 		4 LEU A 145
ARG A 114
THR A  79
LEU A  80
 None
 0.97A 2eikA-1sr4A:
undetectable
2eikJ-1sr4A:
undetectable		 2eikA-1sr4A:
18.06
2eikJ-1sr4A:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 40 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF13177
(DNA_pol3_delta2) 		4 LEU E  40
MET E 158
THR E 157
LEU E 154
 None
 0.98A 2eikA-1sxjE:
undetectable
2eikJ-1sxjE:
undetectable		 2eikA-1sxjE:
19.27
2eikJ-1sxjE:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t33 PUTATIVE
TRANSCRIPTIONAL
REPRESSOR (TETR/ACRR
FAMILY)

(Salmonella
enterica) 		PF00440
(TetR_N)
PF09209
(DUF1956) 		4 LEU A  70
PHE A  69
THR A 111
LEU A 110
 None
 0.97A 2eikA-1t33A:
0.0
2eikJ-1t33A:
undetectable		 2eikA-1t33A:
17.32
2eikJ-1t33A:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uc7 THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBD

(Escherichia
coli) 		PF13899
(Thioredoxin_7) 		4 LEU A  93
PHE A  95
THR A  15
LEU A  80
 None
 1.03A 2eikA-1uc7A:
undetectable
2eikJ-1uc7A:
undetectable		 2eikA-1uc7A:
14.74
2eikJ-1uc7A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcz RNASE NGR3

(Nicotiana
glutinosa) 		PF00445
(Ribonuclease_T2) 		4 ARG A 116
MET A  72
THR A  71
LEU A  68
 None
 1.03A 2eikA-1vczA:
undetectable
2eikJ-1vczA:
undetectable		 2eikA-1vczA:
16.25
2eikJ-1vczA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfr PHEROMONE-BINDING
PROTEIN

(Bombyx mori) 		PF01395
(PBP_GOBP) 		4 LEU A  55
MET A  23
THR A  24
LEU A  25
 None
 1.07A 2eikA-1xfrA:
undetectable
2eikJ-1xfrA:
undetectable		 2eikA-1xfrA:
11.86
2eikJ-1xfrA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bx7 DIHYDROOROTATE
DEHYDROGENASE

(Lactococcus
lactis) 		PF01180
(DHO_dh) 		4 LEU A 128
TYR A 168
MET A 177
LEU A 181
 None
 1.00A 2eikA-2bx7A:
0.0
2eikJ-2bx7A:
undetectable		 2eikA-2bx7A:
19.78
2eikJ-2bx7A:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g2o MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Escherichia
coli) 		PF00698
(Acyl_transf_1) 		4 LEU A  44
PHE A  33
THR A  15
LEU A  56
 None
 1.01A 2eikA-2g2oA:
undetectable
2eikJ-2g2oA:
undetectable		 2eikA-2g2oA:
22.25
2eikJ-2g2oA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibn INOSITOL OXYGENASE

(Homo sapiens) 		PF05153
(MIOX) 		4 LEU A 131
PHE A 132
MET A  71
THR A  72
 None
 1.02A 2eikA-2ibnA:
undetectable
2eikJ-2ibnA:
undetectable		 2eikA-2ibnA:
17.97
2eikJ-2ibnA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3z C2 TOXIN COMPONENT I

(Clostridium
botulinum) 		PF03496
(ADPrib_exo_Tox) 		4 LEU A  89
ARG A  28
THR A  31
LEU A  33
 None
 1.03A 2eikA-2j3zA:
undetectable
2eikJ-2j3zA:
undetectable		 2eikA-2j3zA:
19.36
2eikJ-2j3zA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2la7 UNCHARACTERIZED
PROTEIN

(Paraburkholderia
xenovorans) 		PF03724
(META) 		4 LEU A 112
ARG A 117
THR A 137
LEU A 138
 None
 0.82A 2eikA-2la7A:
undetectable
2eikJ-2la7A:
undetectable		 2eikA-2la7A:
14.14
2eikJ-2la7A:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oby PUTATIVE QUINONE
OXIDOREDUCTASE

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A 286
PHE A 289
THR A 127
LEU A 126
 None
None
NAP  A1400 (-3.2A)
None
 1.09A 2eikA-2obyA:
undetectable
2eikJ-2obyA:
undetectable		 2eikA-2obyA:
21.43
2eikJ-2obyA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ooj HYPOTHETICAL PROTEIN

(Shewanella
oneidensis) 		PF11528
(DUF3224) 		4 PHE A  38
MET A 115
THR A 114
LEU A  97
 None
 1.10A 2eikA-2oojA:
undetectable
2eikJ-2oojA:
undetectable		 2eikA-2oojA:
13.29
2eikJ-2oojA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p14 HETERODIMERIC
RESTRICTION
ENDONUCLEASE
R.BSPD6I SMALL
SUBUNIT

(Bacillus sp. D6) 		PF09491
(RE_AlwI) 		4 LEU A 145
PHE A 152
TYR A  65
LEU A 161
 None
 1.03A 2eikA-2p14A:
undetectable
2eikJ-2p14A:
undetectable		 2eikA-2p14A:
16.34
2eikJ-2p14A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pzi PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNG

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase)
PF16918
(PknG_TPR)
PF16919
(PknG_rubred) 		4 LEU A 426
TYR A 592
THR A 579
LEU A 582
 None
 1.04A 2eikA-2pziA:
undetectable
2eikJ-2pziA:
undetectable		 2eikA-2pziA:
21.85
2eikJ-2pziA:
6.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rcb GLUTAMATE [NMDA]
RECEPTOR SUBUNIT 3B

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		4 LEU A  74
TYR A 271
ARG A 270
LEU A 264
 None
 1.08A 2eikA-2rcbA:
undetectable
2eikJ-2rcbA:
undetectable		 2eikA-2rcbA:
21.58
2eikJ-2rcbA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uvf EXOPOLYGALACTURONASE

(Yersinia
enterocolitica) 		PF00295
(Glyco_hydro_28)
PF12708
(Pectate_lyase_3) 		4 PHE A 347
MET A 334
THR A 335
LEU A 336
 None
 0.89A 2eikA-2uvfA:
undetectable
2eikJ-2uvfA:
undetectable		 2eikA-2uvfA:
22.56
2eikJ-2uvfA:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uw1 PLASTID DELTA4
MULTIFUNCTIONAL
ACYL-ACYL CARRIER
PROTEIN DESATURASE

(Hedera helix) 		PF03405
(FA_desaturase_2) 		4 LEU B 272
MET B 346
THR B 345
LEU B 358
 None
 1.00A 2eikA-2uw1B:
undetectable
2eikJ-2uw1B:
undetectable		 2eikA-2uw1B:
20.56
2eikJ-2uw1B:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w7a LINE-1 ORF1P

(Homo sapiens) 		PF02994
(Transposase_22) 		4 PHE A 186
ARG A 235
THR A 250
LEU A 158
 None
 1.03A 2eikA-2w7aA:
undetectable
2eikJ-2w7aA:
undetectable		 2eikA-2w7aA:
11.56
2eikJ-2w7aA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wok CLAVULANIC ACID
BIOSYNTHESIS
OLIGOPEPTIDE BINDING
PROTEIN 2

(Streptomyces
clavuligerus) 		PF00496
(SBP_bac_5) 		4 LEU A 186
TYR A 101
THR A  98
LEU A 176
 None
 1.04A 2eikA-2wokA:
3.1
2eikJ-2wokA:
undetectable		 2eikA-2wokA:
21.99
2eikJ-2wokA:
7.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ws9 P1

(Equine rhinitis
A virus) 		no annotation 4 LEU 1  84
PHE 1 156
THR 1 198
LEU 1 197
 None
 0.86A 2eikA-2ws91:
undetectable
2eikJ-2ws91:
undetectable		 2eikA-2ws91:
19.07
2eikJ-2ws91:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3c TOXIC EXTRACELLULAR
ENDOPEPTIDASE

(Aeromonas
salmonicida) 		PF14521
(Aspzincin_M35) 		4 LEU A  67
PHE A  68
THR A  43
LEU A  44
 None
 0.80A 2eikA-2x3cA:
undetectable
2eikJ-2x3cA:
undetectable		 2eikA-2x3cA:
20.64
2eikJ-2x3cA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xxl GRAM-POSITIVE
SPECIFIC SERINE
PROTEASE, ISOFORM B

(Drosophila
melanogaster) 		PF00089
(Trypsin)
PF12032
(CLIP) 		4 PHE A 104
ARG A 156
MET A 372
LEU A 226
 None
 1.10A 2eikA-2xxlA:
undetectable
2eikJ-2xxlA:
undetectable		 2eikA-2xxlA:
19.17
2eikJ-2xxlA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y69 CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1

(Bos taurus) 		PF02238
(COX7a) 		5 TYR J  32
ARG J  33
MET J  36
THR J  37
LEU J  40
 None
 0.40A 2eikA-2y69J:
undetectable
2eikJ-2y69J:
8.0		 2eikA-2y69J:
10.31
2eikJ-2y69J:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		4 LEU B 428
ARG B 441
THR B 436
LEU B 435
 None
 0.97A 2eikA-2z7xB:
undetectable
2eikJ-2z7xB:
undetectable		 2eikA-2z7xB:
23.01
2eikJ-2z7xB:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zgk ANTI-TUMOR LECTIN

(Agrocybe
aegerita) 		PF00337
(Gal-bind_lectin) 		4 PHE A  93
ARG A  63
THR A  46
LEU A  47
 None
 1.02A 2eikA-2zgkA:
undetectable
2eikJ-2zgkA:
undetectable		 2eikA-2zgkA:
15.56
2eikJ-2zgkA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ziu MUS81 PROTEIN

(Danio rerio) 		PF02732
(ERCC4) 		4 TYR A 471
MET A 475
THR A 476
LEU A 479
 None
 0.76A 2eikA-2ziuA:
undetectable
2eikJ-2ziuA:
undetectable		 2eikA-2ziuA:
18.55
2eikJ-2ziuA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4

(Homo sapiens) 		PF00168
(C2) 		5 PHE A 189
ARG A 124
MET A 248
THR A 249
LEU A 213
 None
 1.41A 2eikA-3b7yA:
undetectable
2eikJ-3b7yA:
undetectable		 2eikA-3b7yA:
13.39
2eikJ-3b7yA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dby UNCHARACTERIZED
PROTEIN

(Bacillus cereus) 		PF11155
(DUF2935) 		4 LEU A  53
PHE A  50
ARG A  77
LEU A 115
 None
 0.82A 2eikA-3dbyA:
3.1
2eikJ-3dbyA:
undetectable		 2eikA-3dbyA:
17.09
2eikJ-3dbyA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dcp HISTIDINOL-PHOSPHATA
SE

(Listeria
monocytogenes) 		PF02811
(PHP)
PF13263
(PHP_C) 		4 LEU A  30
PHE A  32
TYR A 255
THR A 271
 None
 0.78A 2eikA-3dcpA:
undetectable
2eikJ-3dcpA:
undetectable		 2eikA-3dcpA:
19.37
2eikJ-3dcpA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egj N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE

(Vibrio cholerae) 		PF01979
(Amidohydro_1) 		4 LEU A  60
PHE A  92
TYR A 114
THR A  73
 None
 1.11A 2eikA-3egjA:
undetectable
2eikJ-3egjA:
undetectable		 2eikA-3egjA:
22.35
2eikJ-3egjA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hi8 PROLIFERATING CELL
NUCLEAR ANTIGEN PCNA

(Haloferax
volcanii) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 LEU A  15
ARG A  37
THR A  50
LEU A  51
 None
 0.87A 2eikA-3hi8A:
undetectable
2eikJ-3hi8A:
undetectable		 2eikA-3hi8A:
20.53
2eikJ-3hi8A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iqd OCTOPINE
DEHYDROGENASE

(Pecten maximus) 		PF02317
(Octopine_DH) 		4 LEU B 184
PHE B 194
THR B  16
LEU B  17
 None
 0.92A 2eikA-3iqdB:
undetectable
2eikJ-3iqdB:
undetectable		 2eikA-3iqdB:
21.05
2eikJ-3iqdB:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k13 5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE

(Bacteroides
thetaiotaomicron) 		PF00809
(Pterin_bind) 		4 ARG A 407
MET A 410
THR A 411
LEU A 414
 None
 0.72A 2eikA-3k13A:
undetectable
2eikJ-3k13A:
undetectable		 2eikA-3k13A:
20.20
2eikJ-3k13A:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lki FRUCTOKINASE

(Xylella
fastidiosa) 		PF00294
(PfkB) 		4 LEU A 196
PHE A 173
MET A 148
THR A 149
 None
 1.03A 2eikA-3lkiA:
undetectable
2eikJ-3lkiA:
undetectable		 2eikA-3lkiA:
22.00
2eikJ-3lkiA:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7f E3 UBIQUITIN-PROTEIN
LIGASE NEDD4

(Mus musculus) 		PF00168
(C2) 		4 PHE B 229
MET B 248
THR B 249
LEU B 213
 None
 1.03A 2eikA-3m7fB:
undetectable
2eikJ-3m7fB:
undetectable		 2eikA-3m7fB:
16.56
2eikJ-3m7fB:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nmz APC VARIANT PROTEIN

(Homo sapiens) 		PF00514
(Arm) 		4 LEU A 572
ARG A 527
THR A 562
LEU A 563
 None
 1.00A 2eikA-3nmzA:
undetectable
2eikJ-3nmzA:
undetectable		 2eikA-3nmzA:
21.23
2eikJ-3nmzA:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o6x GLUTAMINE SYNTHETASE

(Bacteroides
fragilis) 		PF00120
(Gln-synt_C)
PF12437
(GSIII_N) 		4 LEU A 355
PHE A 356
MET A 493
LEU A 497
 None
 1.08A 2eikA-3o6xA:
1.3
2eikJ-3o6xA:
undetectable		 2eikA-3o6xA:
21.45
2eikJ-3o6xA:
6.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o96 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00169
(PH) 		4 LEU A 379
PHE A 407
ARG A 249
MET A 343
 LEU  A 379 ( 0.6A)
PHE  A 407 ( 1.3A)
ARG  A 249 ( 0.6A)
MET  A 343 ( 0.0A)
 1.01A 2eikA-3o96A:
0.5
2eikJ-3o96A:
undetectable		 2eikA-3o96A:
19.89
2eikJ-3o96A:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q0x CENTRIOLE PROTEIN

(Chlamydomonas
reinhardtii) 		PF16531
(SAS-6_N) 		4 LEU A 153
PHE A 155
ARG A  48
LEU A  63
 None
 0.79A 2eikA-3q0xA:
undetectable
2eikJ-3q0xA:
2.8		 2eikA-3q0xA:
16.90
2eikJ-3q0xA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3se7 VANA

(-) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 TYR A 315
MET A 319
THR A 320
LEU A 324
 None
 0.95A 2eikA-3se7A:
undetectable
2eikJ-3se7A:
undetectable		 2eikA-3se7A:
21.97
2eikJ-3se7A:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sto SERINE PROTEASE
INHIBITOR

(Schistosoma
haematobium) 		PF00079
(Serpin) 		4 LEU A  47
MET A 392
THR A 391
LEU A 390
 None
 0.96A 2eikA-3stoA:
undetectable
2eikJ-3stoA:
undetectable		 2eikA-3stoA:
20.56
2eikJ-3stoA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wa8 CRISPR-ASSOCIATED
PROTEIN, CSE2 FAMILY

(Meiothermus
ruber) 		PF09485
(CRISPR_Cse2) 		4 LEU A  68
ARG A 164
THR A 105
LEU A 106
 None
 0.74A 2eikA-3wa8A:
undetectable
2eikJ-3wa8A:
undetectable		 2eikA-3wa8A:
13.36
2eikJ-3wa8A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bob ERPP PROTEIN

(Borreliella
burgdorferi) 		PF02471
(OspE) 		4 PHE A  78
MET A  92
THR A  93
LEU A 160
 None
 0.72A 2eikA-4bobA:
undetectable
2eikJ-4bobA:
undetectable		 2eikA-4bobA:
15.65
2eikJ-4bobA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxm ERPC

(Borreliella
burgdorferi) 		PF02471
(OspE) 		4 PHE A  73
MET A  87
THR A  88
LEU A 153
 None
 0.75A 2eikA-4bxmA:
undetectable
2eikJ-4bxmA:
undetectable		 2eikA-4bxmA:
15.42
2eikJ-4bxmA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c6o CAD PROTEIN

(Homo sapiens) 		PF01979
(Amidohydro_1) 		4 LEU A1729
ARG A1722
THR A1716
LEU A1715
 None
 1.09A 2eikA-4c6oA:
undetectable
2eikJ-4c6oA:
undetectable		 2eikA-4c6oA:
23.84
2eikJ-4c6oA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9l 20.1 ANTI-BTN3A1
ANTIBODY FRAGMENT

(Mus musculus) 		no annotation 4 LEU D 142
ARG D 171
THR D 218
LEU D 217
 None
 0.90A 2eikA-4f9lD:
undetectable
2eikJ-4f9lD:
undetectable		 2eikA-4f9lD:
18.81
2eikJ-4f9lD:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g6q PUTATIVE
UNCHARACTERIZED
PROTEIN

(Kribbella
flavida) 		PF12840
(HTH_20) 		4 LEU A  82
ARG A  78
THR A  36
LEU A  39
 None
 0.99A 2eikA-4g6qA:
undetectable
2eikJ-4g6qA:
undetectable		 2eikA-4g6qA:
16.97
2eikJ-4g6qA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gnk 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3

(Homo sapiens) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		4 LEU B 118
PHE B 120
ARG B  44
THR B  55
 None
 1.11A 2eikA-4gnkB:
undetectable
2eikJ-4gnkB:
undetectable		 2eikA-4gnkB:
17.30
2eikJ-4gnkB:
6.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gv1 RAC-ALPHA
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 LEU A 379
PHE A 407
ARG A 249
MET A 343
 None
 1.03A 2eikA-4gv1A:
1.2
2eikJ-4gv1A:
undetectable		 2eikA-4gv1A:
20.00
2eikJ-4gv1A:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j38 OUTER SURFACE
PROTEIN E

(Borreliella
burgdorferi) 		PF02471
(OspE) 		4 PHE A  86
MET A 100
THR A 101
LEU A 166
 None
 0.77A 2eikA-4j38A:
undetectable
2eikJ-4j38A:
undetectable		 2eikA-4j38A:
13.32
2eikJ-4j38A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kem MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Azospirillum
lipoferum) 		PF13378
(MR_MLE_C) 		4 LEU A 275
ARG A 303
MET A 307
LEU A 308
 None
 0.84A 2eikA-4kemA:
undetectable
2eikJ-4kemA:
undetectable		 2eikA-4kemA:
21.75
2eikJ-4kemA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxr PROTEIN TOLL

(Drosophila
melanogaster) 		PF00560
(LRR_1)
PF01462
(LRRNT)
PF13306
(LRR_5)
PF13855
(LRR_8) 		4 PHE A 410
ARG A 396
MET A 421
LEU A 445
 None
 0.98A 2eikA-4lxrA:
undetectable
2eikJ-4lxrA:
undetectable		 2eikA-4lxrA:
20.28
2eikJ-4lxrA:
5.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p8s RETICULON-4
RECEPTOR-LIKE 2

(Rattus
norvegicus) 		PF13855
(LRR_8) 		4 LEU A 258
ARG A 207
THR A 230
LEU A 253
 None
 1.09A 2eikA-4p8sA:
undetectable
2eikJ-4p8sA:
undetectable		 2eikA-4p8sA:
18.85
2eikJ-4p8sA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia pestis) 		PF13407
(Peripla_BP_4) 		4 LEU A 259
MET A 201
THR A 202
LEU A 205
 None
 1.05A 2eikA-4rweA:
undetectable
2eikJ-4rweA:
undetectable		 2eikA-4rweA:
20.54
2eikJ-4rweA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rwt LEIOMODIN-2

(Homo sapiens) 		no annotation 4 ARG C 309
MET C 312
THR C 313
LEU C 316
 None
 0.90A 2eikA-4rwtC:
undetectable
2eikJ-4rwtC:
undetectable		 2eikA-4rwtC:
19.44
2eikJ-4rwtC:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8p TALIN-1
AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER
1-INTERACTING
PROTEIN

(Mus musculus;
Mus musculus) 		no annotation
no annotation 		4 LEU B  15
PHE B  12
THR A1562
LEU A1565
 EDO  A1701 ( 4.8A)
None
None
None
 0.91A 2eikA-4w8pB:
undetectable
2eikJ-4w8pB:
undetectable		 2eikA-4w8pB:
6.75
2eikJ-4w8pB:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w97 HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR KSTR2

(Mycobacterium
tuberculosis) 		PF00440
(TetR_N) 		4 LEU A  69
PHE A  70
ARG A 132
MET A 134
 None
None
UCA  A 301 (-4.1A)
None
 1.06A 2eikA-4w97A:
undetectable
2eikJ-4w97A:
undetectable		 2eikA-4w97A:
17.49
2eikJ-4w97A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y21 PROTEIN UNC-13
HOMOLOG A

(Rattus
norvegicus) 		PF06292
(DUF1041)
PF10540
(Membr_traf_MHD) 		4 LEU A 277
PHE A 274
ARG A 344
LEU A 367
 None
 1.08A 2eikA-4y21A:
undetectable
2eikJ-4y21A:
undetectable		 2eikA-4y21A:
21.36
2eikJ-4y21A:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yk6 ADENOMATOUS
POLYPOSIS COLI
PROTEIN

(Homo sapiens) 		PF00514
(Arm)
PF16629
(Arm_APC_u3) 		4 LEU A 572
ARG A 527
THR A 562
LEU A 563
 None
 0.94A 2eikA-4yk6A:
undetectable
2eikJ-4yk6A:
undetectable		 2eikA-4yk6A:
18.86
2eikJ-4yk6A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3v BILIVERDIN REDUCTASE

(Synechocystis
sp. PCC 6803) 		no annotation 4 LEU B 192
PHE B 193
THR B 256
LEU B 257
 None
 1.01A 2eikA-5b3vB:
undetectable
2eikJ-5b3vB:
undetectable		 2eikA-5b3vB:
19.96
2eikJ-5b3vB:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c9e SEPL

(Escherichia
coli) 		PF07201
(HrpJ) 		4 LEU A 315
PHE A 312
THR A 290
LEU A 289
 None
 0.83A 2eikA-5c9eA:
2.1
2eikJ-5c9eA:
undetectable		 2eikA-5c9eA:
19.39
2eikJ-5c9eA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cxw PENICILLIN-BINDING
PROTEIN 1A

(Mycobacterium
tuberculosis) 		PF00905
(Transpeptidase) 		4 LEU A 356
ARG A 505
THR A 468
LEU A 469
 None
 0.91A 2eikA-5cxwA:
undetectable
2eikJ-5cxwA:
undetectable		 2eikA-5cxwA:
23.22
2eikJ-5cxwA:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czc MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE

(Streptomyces
halstedii) 		no annotation 4 PHE A 237
MET A 127
THR A 128
LEU A 131
 None
 1.09A 2eikA-5czcA:
0.9
2eikJ-5czcA:
undetectable		 2eikA-5czcA:
20.00
2eikJ-5czcA:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d73 GLUTATHIONE
S-TRANSFERASE

(Wuchereria
bancrofti) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 LEU A 125
PHE A 128
ARG A  95
THR A  99
 None
None
GSH  A 301 (-3.8A)
None
 1.01A 2eikA-5d73A:
undetectable
2eikJ-5d73A:
undetectable		 2eikA-5d73A:
16.63
2eikJ-5d73A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF17137
(DUF5110) 		4 PHE A 186
ARG A 109
THR A  99
LEU A  98
 None
 0.79A 2eikA-5dkxA:
undetectable
2eikJ-5dkxA:
undetectable		 2eikA-5dkxA:
18.91
2eikJ-5dkxA:
5.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7p CELL DIVISION
CONTROL PROTEIN
CDC48

(Mycolicibacterium
smegmatis) 		PF00004
(AAA)
PF02359
(CDC48_N) 		4 LEU A 430
ARG A  37
THR A 464
LEU A 463
 None
 0.97A 2eikA-5e7pA:
undetectable
2eikJ-5e7pA:
undetectable		 2eikA-5e7pA:
22.32
2eikJ-5e7pA:
4.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5esp I-PANMI

(Podospora
anserina) 		PF00961
(LAGLIDADG_1) 		4 LEU A 114
ARG A  38
THR A  26
LEU A  25
 None
 1.07A 2eikA-5espA:
undetectable
2eikJ-5espA:
undetectable		 2eikA-5espA:
19.96
2eikJ-5espA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gs0 TOLL-LIKE RECEPTOR 3

(Homo sapiens) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		4 LEU A 279
PHE A 303
THR A 262
LEU A 260
 None
 1.00A 2eikA-5gs0A:
undetectable
2eikJ-5gs0A:
undetectable		 2eikA-5gs0A:
21.21
2eikJ-5gs0A:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hjp OXYSTEROLS RECEPTOR
LXR-BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU B 345
PHE B 340
ARG B 319
LEU B 313
 668  B 501 (-3.5A)
None
668  B 501 (-3.6A)
None
 1.11A 2eikA-5hjpB:
undetectable
2eikJ-5hjpB:
undetectable		 2eikA-5hjpB:
18.22
2eikJ-5hjpB:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6s ENDOPLASMIC
RETICULUM
AMINOPEPTIDASE 2

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 LEU A 928
PHE A 931
THR A 881
LEU A 884
 None
 0.70A 2eikA-5j6sA:
undetectable
2eikJ-5j6sA:
undetectable		 2eikA-5j6sA:
20.29
2eikJ-5j6sA:
5.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k6z PROTEIN
SIDEKICK-2,PROTEIN
SIDEKICK-1 CHIMERA

(Mus musculus) 		PF07679
(I-set)
PF13927
(Ig_3) 		4 LEU A 299
MET A 306
THR A 305
LEU A 350
 None
 1.11A 2eikA-5k6zA:
undetectable
2eikJ-5k6zA:
undetectable		 2eikA-5k6zA:
21.36
2eikJ-5k6zA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9t PROTEIN TRANSLOCASE
SUBUNIT SECA

(Escherichia
coli) 		PF01043
(SecA_PP_bind)
PF07517
(SecA_DEAD) 		4 LEU A 286
ARG A 277
THR A 275
LEU A 274
 None
 0.80A 2eikA-5k9tA:
undetectable
2eikJ-5k9tA:
undetectable		 2eikA-5k9tA:
21.11
2eikJ-5k9tA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3x NEGATIVE ELONGATION
FACTOR C/D

(Homo sapiens) 		PF04858
(TH1) 		4 LEU B 554
ARG B 531
THR B 535
LEU B 538
 None
 1.04A 2eikA-5l3xB:
undetectable
2eikJ-5l3xB:
undetectable		 2eikA-5l3xB:
21.91
2eikJ-5l3xB:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lmc ANAEROBIC NITRIC
OXIDE REDUCTASE
FLAVORUBREDOXIN

(Escherichia
coli) 		PF00258
(Flavodoxin_1)
PF00301
(Rubredoxin)
PF00753
(Lactamase_B) 		4 PHE A 365
ARG A 253
THR A 300
LEU A 299
 None
 0.94A 2eikA-5lmcA:
undetectable
2eikJ-5lmcA:
undetectable		 2eikA-5lmcA:
20.94
2eikJ-5lmcA:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbq OUTER SURFACE
PROTEIN E

(Borreliella
burgdorferi) 		no annotation 4 PHE G  86
MET G 100
THR G 101
LEU G 166
 None
 0.79A 2eikA-5nbqG:
undetectable
2eikJ-5nbqG:
undetectable		 2eikA-5nbqG:
undetectable
2eikJ-5nbqG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqd ARSENITE OXIDASE
LARGE SUBUNIT AIOA
[3FE-4S] CLUSTER,
MO-MOLYBDOPTERIN
COFACTOR-BINDING
ACTIVE SITE

(Rhizobium sp.
NT-26) 		no annotation 4 LEU A 163
ARG A 149
MET A 604
LEU A 600
 None
 0.93A 2eikA-5nqdA:
0.4
2eikJ-5nqdA:
undetectable		 2eikA-5nqdA:
undetectable
2eikJ-5nqdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nxk SERINE-RICH SECRETED
CELL WALL ANCHORED
(LPXTG-MOTIF )
PROTEIN

(Lactobacillus
reuteri) 		no annotation 4 LEU A 424
MET A 474
THR A 473
LEU A 472
 None
 1.09A 2eikA-5nxkA:
undetectable
2eikJ-5nxkA:
undetectable		 2eikA-5nxkA:
undetectable
2eikJ-5nxkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0l RETICULON-4 RECEPTOR

(Mus musculus) 		no annotation 4 LEU A 112
ARG A  61
THR A  84
LEU A 107
 None
 1.00A 2eikA-5o0lA:
undetectable
2eikJ-5o0lA:
undetectable		 2eikA-5o0lA:
20.26
2eikJ-5o0lA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5obu CHAPERONE PROTEIN
DNAK

(Mycoplasma
genitalium) 		no annotation 4 LEU A 392
PHE A 457
ARG A 437
LEU A 522
 None
 1.01A 2eikA-5obuA:
undetectable
2eikJ-5obuA:
undetectable		 2eikA-5obuA:
undetectable
2eikJ-5obuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqj RNA POLYMERASE II
TRANSCRIPTION FACTOR
B SUBUNIT 1

(Saccharomyces
cerevisiae) 		no annotation 4 LEU 1  60
PHE 1  91
THR 1  28
LEU 1  27
 None
 0.64A 2eikA-5oqj1:
undetectable
2eikJ-5oqj1:
undetectable		 2eikA-5oqj1:
undetectable
2eikJ-5oqj1:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqm GENERAL
TRANSCRIPTION AND
DNA REPAIR FACTOR
IIH SUBUNIT TFB1

(Saccharomyces
cerevisiae) 		no annotation 4 LEU 1  60
PHE 1  91
THR 1  28
LEU 1  27
 None
 0.67A 2eikA-5oqm1:
undetectable
2eikJ-5oqm1:
undetectable		 2eikA-5oqm1:
undetectable
2eikJ-5oqm1:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj3 ALKALINE PHOSPHATASE
PAFA

(Elizabethkingia
meningoseptica) 		PF01663
(Phosphodiest) 		4 PHE A  57
ARG A 324
THR A 273
LEU A 276
 None
 1.08A 2eikA-5tj3A:
undetectable
2eikJ-5tj3A:
undetectable		 2eikA-5tj3A:
22.47
2eikJ-5tj3A:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v6b PDZ
DOMAIN-CONTAINING
PROTEIN GIPC1

(Mus musculus) 		PF00595
(PDZ) 		4 ARG A 307
MET A 287
THR A 286
LEU A 283
 None
 1.06A 2eikA-5v6bA:
undetectable
2eikJ-5v6bA:
undetectable		 2eikA-5v6bA:
17.68
2eikJ-5v6bA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wug BETA-GLUCOSIDASE

(Paenibacillus
barengoltzii) 		no annotation 4 LEU A 243
TYR A  76
ARG A  78
LEU A 591
 None
 0.89A 2eikA-5wugA:
undetectable
2eikJ-5wugA:
undetectable		 2eikA-5wugA:
undetectable
2eikJ-5wugA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfa NAD-REDUCING
HYDROGENASE

(Hydrogenophilus
thermoluteolus) 		PF01257
(2Fe-2S_thioredx)
PF01512
(Complex1_51K)
PF10589
(NADH_4Fe-4S) 		4 LEU A 538
ARG A 511
THR A 505
LEU A 550
 None
 0.94A 2eikA-5xfaA:
undetectable
2eikJ-5xfaA:
undetectable		 2eikA-5xfaA:
22.80
2eikJ-5xfaA:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xk8 UNDECAPRENYL
DIPHOSPHATE SYNTHASE

(Streptomyces
sp. CNH189) 		no annotation 4 TYR A  26
MET A  29
THR A  30
LEU A  33
 None
 1.01A 2eikA-5xk8A:
undetectable
2eikJ-5xk8A:
undetectable		 2eikA-5xk8A:
undetectable
2eikJ-5xk8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xum HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE

(Thermotoga
maritima) 		no annotation 4 LEU A 123
PHE A 122
THR A 147
LEU A 148
 None
 1.05A 2eikA-5xumA:
undetectable
2eikJ-5xumA:
undetectable		 2eikA-5xumA:
undetectable
2eikJ-5xumA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yk2 PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER

(Mycobacterium
tuberculosis) 		no annotation 4 LEU A 268
PHE A 227
ARG A 278
LEU A 431
 None
 1.08A 2eikA-5yk2A:
undetectable
2eikJ-5yk2A:
undetectable		 2eikA-5yk2A:
21.51
2eikJ-5yk2A:
9.65