SIMILAR PATTERNS OF AMINO ACIDS FOR 2EGV_A_SAMA1300_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dys ENDOGLUCANASE

(Humicola
insolens) 		PF01341
(Glyco_hydro_6) 		5 LEU A  12
ASN A  14
VAL A  81
GLY A  82
ALA A  65
 None
 0.93A 2egvA-1dysA:
undetectable		 2egvA-1dysA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3m THE CONSERVED
HYPOTHETICAL PROTEIN
TT1751

(Thermus
thermophilus) 		PF03625
(DUF302) 		5 LEU A  82
LEU A  92
THR A   7
LEU A   8
ALA A  15
 None
 0.76A 2egvA-1j3mA:
undetectable		 2egvA-1j3mA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jlk RESPONSE REGULATOR
RCP1

(Synechocystis
sp. PCC 6803) 		PF00072
(Response_reg) 		5 VAL A  79
GLY A  76
LEU A  12
LEU A  40
ALA A  46
 None
 0.92A 2egvA-1jlkA:
3.1		 2egvA-1jlkA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jn0 GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
A

(Spinacia
oleracea) 		no annotation 5 VAL O 214
GLY O 209
LEU O 242
THR O 174
THR O 151
 None
SO4  O6337 (-3.7A)
None
None
None
 1.07A 2egvA-1jn0O:
2.7		 2egvA-1jn0O:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lam LEUCINE
AMINOPEPTIDASE

(Bos taurus) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 LEU A 299
VAL A 248
GLY A 249
GLY A 251
ALA A 342
 None
 0.88A 2egvA-1lamA:
undetectable		 2egvA-1lamA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mox EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		5 PHE A 335
GLY A 343
GLY A 315
LEU A 399
LEU A 381
 None
 0.91A 2egvA-1moxA:
undetectable		 2egvA-1moxA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ns5 HYPOTHETICAL PROTEIN
YBEA

(Escherichia
coli) 		PF02590
(SPOUT_MTase) 		5 LEU A  72
GLY A 103
GLY A 107
LEU A 122
LEU A 127
 None
 0.48A 2egvA-1ns5A:
8.3		 2egvA-1ns5A:
21.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nxz HYPOTHETICAL PROTEIN
HI0303

(Haemophilus
influenzae) 		PF04452
(Methyltrans_RNA) 		6 LEU A 171
GLY A 195
LEU A 218
LEU A 223
THR A 225
ALA A 228
 None
 0.87A 2egvA-1nxzA:
22.1		 2egvA-1nxzA:
30.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ooe DIHYDROPTERIDINE
REDUCTASE

(Caenorhabditis
elegans) 		PF00106
(adh_short) 		5 LEU A 125
VAL A  76
GLY A  75
LEU A 164
ALA A 115
 None
 1.01A 2egvA-1ooeA:
2.1		 2egvA-1ooeA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8i DNA POLYMERASE II

(Escherichia
coli) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 LEU A  96
VAL A 101
GLY A 100
LEU A  57
ALA A  53
 None
 1.05A 2egvA-1q8iA:
undetectable		 2egvA-1q8iA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rjw ALCOHOL
DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 VAL A  64
GLY A  65
LEU A 296
LEU A 138
ALA A 143
 None
 0.77A 2egvA-1rjwA:
2.9		 2egvA-1rjwA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1scj SUBTILISIN E

(Bacillus
subtilis) 		PF00082
(Peptidase_S8) 		5 VAL A 165
GLY A 166
GLY A 127
THR A 224
ALA A 176
 None
None
None
None
CA  A 382 (-3.8A)
 1.06A 2egvA-1scjA:
2.2		 2egvA-1scjA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t4o RIBONUCLEASE III

(Saccharomyces
cerevisiae) 		PF00035
(dsrm) 		5 ASN A 430
GLY A 424
GLY A 415
LEU A 432
ALA A 370
 None
 0.81A 2egvA-1t4oA:
undetectable		 2egvA-1t4oA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tlt PUTATIVE
OXIDOREDUCTASE
(VIRULENCE FACTOR
MVIM HOMOLOG)

(Escherichia
coli) 		PF01408
(GFO_IDH_MocA) 		5 LEU A  85
VAL A  90
GLY A  89
LEU A  59
ALA A  63
 None
 0.80A 2egvA-1tltA:
4.6		 2egvA-1tltA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ufr PYR MRNA-BINDING
ATTENUATION PROTEIN

(Thermus
thermophilus) 		PF00156
(Pribosyltran) 		5 LEU A  67
GLY A  38
GLY A  43
THR A  70
ALA A 115
 None
 1.02A 2egvA-1ufrA:
undetectable		 2egvA-1ufrA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ufr PYR MRNA-BINDING
ATTENUATION PROTEIN

(Thermus
thermophilus) 		PF00156
(Pribosyltran) 		5 LEU A  67
VAL A  37
GLY A  38
GLY A  43
THR A 111
 None
None
None
None
CL  A 182 (-4.2A)
 1.00A 2egvA-1ufrA:
undetectable		 2egvA-1ufrA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6z HYPOTHETICAL PROTEIN
TTHA0657

(Thermus
thermophilus) 		PF04452
(Methyltrans_RNA) 		6 VAL A 180
GLY A 181
GLY A 185
LEU A 204
LEU A 209
ALA A 214
 None
 0.38A 2egvA-1v6zA:
23.8		 2egvA-1v6zA:
28.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhk HYPOTHETICAL PROTEIN
YQEU

(Bacillus
subtilis) 		PF04452
(Methyltrans_RNA) 		6 GLY A 204
GLY A 208
LEU A 227
LEU A 232
THR A 234
ALA A 237
 None
 0.55A 2egvA-1vhkA:
23.9		 2egvA-1vhkA:
26.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b0l GTP-SENSING
TRANSCRIPTIONAL
PLEIOTROPIC
REPRESSOR CODY

(Bacillus
subtilis) 		PF08222
(HTH_CodY) 		5 LEU A 224
VAL A 229
GLY A 228
LEU A 179
ALA A 175
 None
 0.88A 2egvA-2b0lA:
undetectable		 2egvA-2b0lA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1

(Homo sapiens) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		5 LEU A 808
VAL A 813
GLY A 812
GLY A 878
ALA A 784
 None
 0.67A 2egvA-2b3xA:
undetectable		 2egvA-2b3xA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwg GMP REDUCTASE I

(Homo sapiens) 		PF00478
(IMPDH) 		5 VAL A 180
GLY A 181
GLY A 183
THR A 188
ALA A 287
 None
K  A1339 (-4.8A)
5GP  A1340 ( 3.2A)
5GP  A1340 ( 4.7A)
5GP  A1340 (-3.9A)
 1.04A 2egvA-2bwgA:
undetectable		 2egvA-2bwgA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwp 5-AMINOLEVULINATE
SYNTHASE

(Rhodobacter
capsulatus) 		PF00155
(Aminotran_1_2) 		5 LEU A 350
VAL A 356
GLY A 355
LEU A 396
ALA A 392
 None
 0.97A 2egvA-2bwpA:
undetectable		 2egvA-2bwpA:
19.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2egw UPF0088 PROTEIN
AQ_165

(Aquifex
aeolicus) 		PF04452
(Methyltrans_RNA) 		12 LEU A 161
ASN A 163
PHE A 164
VAL A 184
GLY A 185
GLY A 189
LEU A 207
LEU A 208
THR A 212
LEU A 213
THR A 215
ALA A 218
 SAH  A 300 ( 3.7A)
SAH  A 300 ( 3.9A)
SAH  A 300 ( 4.7A)
SAH  A 300 ( 3.7A)
SAH  A 300 ( 3.6A)
SAH  A 300 ( 3.6A)
None
SAH  A 300 ( 3.6A)
SAH  A 300 ( 4.0A)
SAH  A 300 ( 4.0A)
SAH  A 300 ( 4.5A)
SAH  A 300 ( 3.6A)
 0.33A 2egvA-2egwA:
35.9		 2egvA-2egwA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fj0 CARBOXYLIC ESTER
HYDROLASE

(Manduca sexta) 		PF00135
(COesterase) 		5 ASN A 174
VAL A  58
GLY A  57
GLY A  89
LEU A 202
 None
 1.05A 2egvA-2fj0A:
undetectable		 2egvA-2fj0A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g4o 3-ISOPROPYLMALATE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00180
(Iso_dh) 		5 GLY A  10
GLY A  12
LEU A  83
LEU A  78
ALA A  39
 None
 1.08A 2egvA-2g4oA:
undetectable		 2egvA-2g4oA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hj9 AUTOINDUCER
2-BINDING
PERIPLASMIC PROTEIN
LUXP

(Vibrio harveyi) 		PF13407
(Peripla_BP_4) 		5 VAL A 176
GLY A 177
LEU A  48
THR A 315
ALA A 318
 None
 0.66A 2egvA-2hj9A:
undetectable		 2egvA-2hj9A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9u CYTOSINE/GUANINE
DEAMINASE RELATED
PROTEIN

(Clostridium
acetobutylicum) 		PF01979
(Amidohydro_1) 		5 LEU A 132
VAL A 157
GLY A 158
LEU A 118
THR A 141
 None
 1.03A 2egvA-2i9uA:
undetectable		 2egvA-2i9uA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ij9 URIDYLATE KINASE

(Archaeoglobus
fulgidus) 		PF00696
(AA_kinase) 		5 LEU A   7
VAL A  11
LEU A   5
THR A 136
ALA A 135
 None
 1.05A 2egvA-2ij9A:
4.1		 2egvA-2ij9A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o78 PUTATIVE HISTIDINE
AMMONIA-LYASE

(Rhodobacter
sphaeroides) 		PF00221
(Lyase_aromatic) 		5 LEU A 369
VAL A 368
LEU A 222
LEU A 362
THR A 364
 None
 0.95A 2egvA-2o78A:
undetectable		 2egvA-2o78A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oa5 HYPOTHETICAL PROTEIN
BQLF2

(Murid
gammaherpesvirus
4) 		PF05812
(Herpes_BLRF2) 		5 LEU A  88
THR A  86
LEU A  85
THR A  81
ALA A  79
 None
 1.08A 2egvA-2oa5A:
undetectable		 2egvA-2oa5A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oda HYPOTHETICAL PROTEIN
PSPTO_2114

(Pseudomonas
syringae group
genomosp. 3) 		no annotation 5 LEU A 131
GLY A 135
GLY A  21
LEU A 176
LEU A  17
 None
 1.01A 2egvA-2odaA:
3.7		 2egvA-2odaA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r62 CELL DIVISION
PROTEASE FTSH
HOMOLOG

(Helicobacter
pylori) 		PF00004
(AAA) 		5 LEU A 314
GLY A 235
LEU A 207
LEU A 208
ALA A 220
 None
 0.85A 2egvA-2r62A:
undetectable		 2egvA-2r62A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rkv TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E

(Fusarium
graminearum) 		PF02458
(Transferase) 		5 LEU A 244
LEU A 327
THR A 249
THR A 261
ALA A 264
 None
None
None
COA  A 452 (-3.7A)
None
 0.77A 2egvA-2rkvA:
undetectable		 2egvA-2rkvA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2veo LIPASE A

(Moesziomyces
antarcticus) 		PF03583
(LIP) 		5 LEU A 166
ASN A 168
GLY A 162
GLY A  34
LEU A 172
 None
 0.94A 2egvA-2veoA:
undetectable		 2egvA-2veoA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynm LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT B

(Prochlorococcus
marinus) 		PF00148
(Oxidored_nitro)
PF08369
(PCP_red) 		5 LEU D  26
PHE D  84
LEU D  89
LEU D  90
THR D  21
 None
 0.91A 2egvA-2ynmD:
undetectable		 2egvA-2ynmD:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ynm LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT B

(Prochlorococcus
marinus) 		PF00148
(Oxidored_nitro)
PF08369
(PCP_red) 		5 PHE D  84
LEU D  89
LEU D  90
THR D  21
ALA D  20
 None
 1.08A 2egvA-2ynmD:
undetectable		 2egvA-2ynmD:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zba TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E

(Fusarium
sporotrichioides) 		PF02458
(Transferase) 		5 LEU A 252
LEU A 335
THR A 257
THR A 269
ALA A 272
 None
None
None
COA  A 462 (-3.7A)
None
 0.78A 2egvA-2zbaA:
undetectable		 2egvA-2zbaA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxo SINGLE-STRANDED DNA
SPECIFIC EXONUCLEASE
RECJ

(Thermus
thermophilus) 		PF01368
(DHH)
PF02272
(DHHA1) 		5 LEU A 589
GLY A 606
LEU A 587
LEU A 544
ALA A 549
 None
 1.04A 2egvA-2zxoA:
2.2		 2egvA-2zxoA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ab7 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0350

(Thermus
thermophilus) 		PF00582
(Usp) 		5 LEU A 208
VAL A 213
GLY A 212
LEU A 171
ALA A 175
 LEU  A 208 ( 0.6A)
VAL  A 213 ( 0.6A)
GLY  A 212 ( 0.0A)
LEU  A 171 ( 0.6A)
ALA  A 175 ( 0.0A)
 0.88A 2egvA-3ab7A:
3.0		 2egvA-3ab7A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3doc GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Brucella
abortus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 VAL A 217
GLY A 212
LEU A 245
THR A 178
THR A 155
 None
 1.09A 2egvA-3docA:
2.6		 2egvA-3docA:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqn GLUCAN
1,3-BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium) 		PF12708
(Pectate_lyase_3) 		5 VAL A 310
LEU A 629
THR A 717
LEU A 716
THR A 747
 None
 0.74A 2egvA-3eqnA:
undetectable		 2egvA-3eqnA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f7c PROTEIN OF UNKNOWN
FUNCTION (DUF416)

(Marinobacter
hydrocarbonoclasticus) 		PF04222
(DUF416) 		5 LEU A  22
LEU A  99
LEU A 121
THR A 123
ALA A 122
 None
 0.98A 2egvA-3f7cA:
undetectable		 2egvA-3f7cA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5j 3-ISOPROPYLMALATE
DEHYDRATASE SMALL
SUBUNIT

(Mycobacterium
tuberculosis) 		PF00694
(Aconitase_C) 		5 LEU A  65
VAL A  12
GLY A  11
GLY A   9
LEU A  84
 None
 0.96A 2egvA-3h5jA:
undetectable		 2egvA-3h5jA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4j AMINOTRANSFERASE,
CLASS III

(Deinococcus
radiodurans) 		PF00202
(Aminotran_3) 		5 LEU A 352
GLY A 350
GLY A 326
LEU A 402
ALA A 206
 None
 0.83A 2egvA-3i4jA:
undetectable		 2egvA-3i4jA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ifw UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L1

(Homo sapiens) 		PF01088
(Peptidase_C12) 		5 LEU A  17
VAL A  22
GLY A  21
LEU A  13
THR A  92
 None
 1.07A 2egvA-3ifwA:
undetectable		 2egvA-3ifwA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ij3 CYTOSOL
AMINOPEPTIDASE

(Coxiella
burnetii) 		PF00883
(Peptidase_M17) 		5 LEU A 275
VAL A 224
GLY A 225
GLY A 227
ALA A 318
 None
 0.85A 2egvA-3ij3A:
undetectable		 2egvA-3ij3A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2b GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
A, CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 VAL A 214
GLY A 209
LEU A 242
THR A 174
THR A 151
 None
SO4  A 337 (-4.0A)
None
None
None
 1.02A 2egvA-3k2bA:
3.7		 2egvA-3k2bA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l0d GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Bartonella
henselae) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 VAL A 217
GLY A 212
LEU A 245
THR A 178
THR A 155
 None
 1.05A 2egvA-3l0dA:
3.1		 2egvA-3l0dA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l76 ASPARTOKINASE

(Synechocystis
sp. PCC 6803) 		PF00696
(AA_kinase)
PF01842
(ACT)
PF13840
(ACT_7) 		5 LEU A 379
VAL A 384
GLY A 383
LEU A 412
ALA A 408
 None
 0.87A 2egvA-3l76A:
2.9		 2egvA-3l76A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwr A RUBISCO-LIKE
PROTEIN

(Paraburkholderia
fungorum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 PHE A 428
GLY A 383
LEU A 411
LEU A 421
ALA A 401
 GOL  A 437 ( 4.7A)
GOL  A 437 (-3.9A)
None
None
None
 0.97A 2egvA-3nwrA:
3.5		 2egvA-3nwrA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odt PROTEIN DOA1

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		5 ASN A  79
GLY A  73
LEU A  70
THR A  94
LEU A  95
 None
 1.09A 2egvA-3odtA:
undetectable		 2egvA-3odtA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pym GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
3

(Saccharomyces
cerevisiae) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 VAL A 215
GLY A 210
LEU A 243
THR A 175
THR A 152
 None
 1.09A 2egvA-3pymA:
3.3		 2egvA-3pymA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qld MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 VAL A 268
GLY A 271
LEU A 254
THR A 279
ALA A 282
 None
 0.85A 2egvA-3qldA:
2.5		 2egvA-3qldA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae) 		PF08659
(KR) 		5 LEU A 121
VAL A 126
GLY A 125
LEU A 117
LEU A  71
 None
 0.74A 2egvA-3qp9A:
undetectable		 2egvA-3qp9A:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rd5 MYPAA.01249.C

(Mycobacterium
avium) 		PF00106
(adh_short) 		5 LEU A 191
VAL A 133
LEU A 241
THR A 233
ALA A 236
 None
 1.09A 2egvA-3rd5A:
2.9		 2egvA-3rd5A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ri6 O-ACETYLHOMOSERINE
SULFHYDRYLASE

(Wolinella
succinogenes) 		PF01053
(Cys_Met_Meta_PP) 		5 LEU A 307
ASN A 303
THR A 328
LEU A 327
ALA A 290
 None
 1.04A 2egvA-3ri6A:
undetectable		 2egvA-3ri6A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s1t ASPARTOKINASE

(Mycobacterium
tuberculosis) 		PF01842
(ACT)
PF13840
(ACT_7) 		5 LEU A 119
VAL A 124
GLY A 123
LEU A 152
ALA A 148
 None
 0.92A 2egvA-3s1tA:
undetectable		 2egvA-3s1tA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3un9 NLR FAMILY MEMBER X1

(Homo sapiens) 		PF13516
(LRR_6) 		5 LEU A 703
ASN A 731
VAL A 706
GLY A 705
LEU A 701
 None
 0.91A 2egvA-3un9A:
undetectable		 2egvA-3un9A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zpx LIPASE

(Ustilago maydis) 		PF03583
(LIP) 		5 LEU A 166
ASN A 168
GLY A 162
GLY A  34
LEU A 172
 None
 0.91A 2egvA-3zpxA:
undetectable		 2egvA-3zpxA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4be9 STEROL ESTERASE

(Ophiostoma
piceae) 		PF00135
(COesterase) 		5 LEU A 111
ASN A 141
VAL A  38
GLY A  37
GLY A  69
 None
None
None
NO3  A1557 ( 4.1A)
NO3  A1557 ( 4.0A)
 0.87A 2egvA-4be9A:
undetectable		 2egvA-4be9A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ei8 PLASMID REPLICATION
PROTEIN REPX

(Bacillus cereus) 		PF00091
(Tubulin) 		5 LEU A 277
ASN A 275
GLY A 280
LEU A 273
LEU A 254
 None
 0.90A 2egvA-4ei8A:
undetectable		 2egvA-4ei8A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4o HAPTOGLOBIN

(Sus scrofa) 		PF00089
(Trypsin) 		5 LEU C 139
GLY C 297
GLY C 129
LEU C 190
THR C 141
 None
 0.80A 2egvA-4f4oC:
undetectable		 2egvA-4f4oC:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g2c DYP2

(Amycolatopsis
sp. ATCC 39116) 		no annotation 5 VAL A  90
GLY A  91
LEU A  40
LEU A 143
LEU A  43
 None
 1.07A 2egvA-4g2cA:
undetectable		 2egvA-4g2cA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gmf YERSINIABACTIN
BIOSYNTHETIC PROTEIN
YBTU

(Yersinia
enterocolitica) 		PF01408
(GFO_IDH_MocA) 		5 LEU A 239
VAL A 246
LEU A 170
LEU A 138
THR A 136
 None
 1.07A 2egvA-4gmfA:
3.1		 2egvA-4gmfA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4go5 ASPARTOKINASE

(Mycobacterium
tuberculosis) 		PF01842
(ACT)
PF13840
(ACT_7) 		5 LEU X 119
VAL X 124
GLY X 123
LEU X 152
ALA X 148
 None
 0.91A 2egvA-4go5X:
undetectable		 2egvA-4go5X:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hds ARSB

(Sporomusa ovata) 		PF02277
(DBI_PRT) 		5 GLY B 170
GLY B 304
LEU B 251
THR B 253
ALA B 252
 None
 0.99A 2egvA-4hdsB:
undetectable		 2egvA-4hdsB:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4isb LONG CHAIN FATTY
ACID COA LIGASE
FADD10

(Mycobacterium
tuberculosis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 LEU A 118
VAL A  71
LEU A  54
LEU A  81
THR A  79
 None
 1.00A 2egvA-4isbA:
undetectable		 2egvA-4isbA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3c RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Sinorhizobium
meliloti) 		PF04452
(Methyltrans_RNA) 		5 GLY A 195
GLY A 199
LEU A 219
LEU A 224
ALA A 229
 None
 0.36A 2egvA-4j3cA:
20.7		 2egvA-4j3cA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jwj TRNA
(GUANINE(9)-N1)-METH
YLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01746
(tRNA_m1G_MT) 		5 VAL A 205
GLY A 206
LEU A 232
LEU A 246
THR A 248
 SAH  A 302 (-3.6A)
SAH  A 302 (-3.1A)
SAH  A 302 (-3.8A)
SAH  A 302 (-4.2A)
SAH  A 302 ( 4.4A)
 0.56A 2egvA-4jwjA:
9.0		 2egvA-4jwjA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k5y CORTICOTROPIN-RELEAS
ING FACTOR RECEPTOR
1, T4-LYSOZYME
CHIMERIC CONSTRUCT

(Homo sapiens;
Escherichia
virus T4) 		PF00002
(7tm_2)
PF00959
(Phage_lysozyme) 		5 LEU A1039
GLY A1023
THR A1026
LEU A1033
ALA A1042
 None
 1.06A 2egvA-4k5yA:
undetectable		 2egvA-4k5yA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpn NUCLEOSIDE
N-RIBOHYDROLASE 1

(Physcomitrella
patens) 		PF01156
(IU_nuc_hydro) 		5 LEU A  48
VAL A  78
GLY A  81
THR A  61
ALA A  64
 None
 0.70A 2egvA-4kpnA:
4.4		 2egvA-4kpnA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpo NUCLEOSIDE
N-RIBOHYDROLASE 3

(Zea mays) 		PF01156
(IU_nuc_hydro) 		5 LEU A  31
VAL A  61
GLY A  64
THR A  44
ALA A  47
 None
 0.77A 2egvA-4kpoA:
4.4		 2egvA-4kpoA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l69 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Mycobacterium
tuberculosis) 		PF04452
(Methyltrans_RNA) 		6 LEU A 175
VAL A 198
GLY A 199
GLY A 203
LEU A 222
ALA A 232
 None
 0.61A 2egvA-4l69A:
23.3		 2egvA-4l69A:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p2b GLUTAMINE
AMINOACYL-TRNA
SYNTHETASE

(Toxoplasma
gondii) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C) 		5 LEU A 309
VAL A 314
GLY A 313
LEU A 303
THR A 572
 None
 0.99A 2egvA-4p2bA:
2.2		 2egvA-4p2bA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p8r GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE,
CYTOSOLIC

(Trypanosoma
brucei) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 VAL A 215
GLY A 210
LEU A 243
THR A 175
THR A 152
 None
 1.06A 2egvA-4p8rA:
undetectable		 2egvA-4p8rA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ppz SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Neisseria
meningitidis) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 LEU A 277
VAL A 282
GLY A 281
LEU A 216
ALA A 212
 None
 1.04A 2egvA-4ppzA:
undetectable		 2egvA-4ppzA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rg1 C9ORF114

(Homo sapiens) 		PF02598
(Methyltrn_RNA_3) 		5 GLY A 312
GLY A 316
THR A 350
THR A 353
ALA A 356
 SAH  A 401 (-3.1A)
SAH  A 401 (-3.3A)
SAH  A 401 (-4.2A)
SAH  A 401 (-4.3A)
SAH  A 401 (-3.4A)
 0.79A 2egvA-4rg1A:
13.2		 2egvA-4rg1A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4trb PURINE
PHOSPHORIBOSYLTRANSF
ERASE (GPT-1)

(Sulfolobus
solfataricus) 		PF00156
(Pribosyltran) 		5 LEU A  53
VAL A  52
LEU A  21
THR A  19
ALA A  22
 None
 1.05A 2egvA-4trbA:
undetectable		 2egvA-4trbA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjg HAPTOGLOBIN

(Homo sapiens) 		no annotation 5 LEU C 194
GLY C 352
GLY C 184
LEU C 245
THR C 196
 None
 0.82A 2egvA-4wjgC:
undetectable		 2egvA-4wjgC:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x0l HAPTOGLOBIN

(Homo sapiens) 		PF00089
(Trypsin) 		5 LEU C 198
GLY C 356
GLY C 188
LEU C 249
THR C 200
 None
 0.75A 2egvA-4x0lC:
2.5		 2egvA-4x0lC:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xni DI-OR TRIPEPTIDE:H+
SYMPORTER

(Streptococcus
thermophilus) 		PF00854
(PTR2) 		5 LEU A 125
ASN A 128
GLY A 123
GLY A  74
THR A 131
 None
 0.80A 2egvA-4xniA:
undetectable		 2egvA-4xniA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yfl 1B2530 LIGHT CHAIN

(Homo sapiens) 		no annotation 5 GLY L 101
GLY L  99
LEU L  46
LEU L  47
LEU L  73
 None
 0.77A 2egvA-4yflL:
undetectable		 2egvA-4yflL:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zow MULTIDRUG
TRANSPORTER MDFA

(Escherichia
coli) 		PF07690
(MFS_1) 		5 GLY A 354
LEU A 233
LEU A 236
THR A 362
LEU A  62
 None
None
CLM  A 500 (-4.9A)
None
None
 0.96A 2egvA-4zowA:
undetectable		 2egvA-4zowA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5apg TSR3

(Vulcanisaeta
distributa) 		PF04034
(Ribo_biogen_C) 		5 LEU A  45
LEU A  93
LEU A 110
THR A 112
ALA A 115
 EEM  A1185 (-3.9A)
EEM  A1185 (-3.9A)
EEM  A1185 (-4.1A)
EEM  A1185 (-3.9A)
EEM  A1185 (-3.4A)
 0.46A 2egvA-5apgA:
5.6		 2egvA-5apgA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp1 MYCOCEROSIC ACID
SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 LEU A 201
GLY A 204
LEU A 250
THR A 102
ALA A 106
 None
 0.94A 2egvA-5bp1A:
undetectable		 2egvA-5bp1A:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey0 GTP-SENSING
TRANSCRIPTIONAL
PLEIOTROPIC
REPRESSOR CODY

(Staphylococcus
aureus) 		no annotation 5 LEU B 224
VAL B 229
GLY B 228
LEU B 179
ALA B 175
 None
 0.94A 2egvA-5ey0B:
undetectable		 2egvA-5ey0B:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5im3 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Pseudomonas
aeruginosa) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		5 LEU A 236
VAL A 241
GLY A 240
LEU A 318
ALA A 257
 None
 1.02A 2egvA-5im3A:
undetectable		 2egvA-5im3A:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iwz SYNAPTONEMAL COMPLEX
PROTEIN 2

(Mus musculus) 		no annotation 5 LEU A 288
LEU A 371
LEU A 370
THR A 355
LEU A 356
 None
 1.07A 2egvA-5iwzA:
undetectable		 2egvA-5iwzA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum) 		PF00920
(ILVD_EDD) 		5 ASN A  60
GLY A 151
THR A  52
LEU A 124
THR A 149
 None
 1.01A 2egvA-5j84A:
undetectable		 2egvA-5j84A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jmv PROBABLE
BIFUNCTIONAL TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN

(Methanocaldococcus
jannaschii) 		PF00814
(Peptidase_M22) 		5 GLY A 286
GLY A  16
LEU A 116
LEU A 292
ALA A 109
 None
 0.89A 2egvA-5jmvA:
undetectable		 2egvA-5jmvA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5loe GTP-SENSING
TRANSCRIPTIONAL
PLEIOTROPIC
REPRESSOR CODY

(Bacillus
subtilis) 		PF06018
(CodY)
PF08222
(HTH_CodY) 		5 LEU A 224
VAL A 229
GLY A 228
LEU A 179
ALA A 175
 None
 0.93A 2egvA-5loeA:
undetectable		 2egvA-5loeA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq3 CMEB

(Campylobacter
jejuni) 		PF00873
(ACR_tran) 		5 LEU A1002
GLY A1004
GLY A 906
LEU A 928
LEU A 932
 None
 0.96A 2egvA-5lq3A:
undetectable		 2egvA-5lq3A:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lst ATP-DEPENDENT DNA
HELICASE Q4

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 LEU A 628
VAL A 634
GLY A 633
LEU A 584
LEU A 590
 None
 0.89A 2egvA-5lstA:
undetectable		 2egvA-5lstA:
16.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5o96 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Legionella
pneumophila) 		no annotation 6 GLY A 196
GLY A 200
LEU A 219
LEU A 224
THR A 226
ALA A 229
 SAM  A 501 (-4.1A)
SAM  A 501 (-2.9A)
SAM  A 501 (-4.9A)
SAM  A 501 (-4.5A)
SAM  A 501 (-3.7A)
SAM  A 501 (-3.3A)
 0.47A 2egvA-5o96A:
22.8		 2egvA-5o96A:
31.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5o96 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Legionella
pneumophila) 		no annotation 6 LEU A 173
GLY A 196
GLY A 200
LEU A 219
THR A 226
ALA A 229
 SAM  A 501 (-4.2A)
SAM  A 501 (-4.1A)
SAM  A 501 (-2.9A)
SAM  A 501 (-4.9A)
SAM  A 501 (-3.7A)
SAM  A 501 (-3.3A)
 0.94A 2egvA-5o96A:
22.8		 2egvA-5o96A:
31.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqr CONDENSIN COMPLEX
SUBUNIT 3

(Schizosaccharomyces
pombe) 		no annotation 5 LEU A 662
VAL A 661
LEU A 643
THR A 619
ALA A 622
 None
 0.86A 2egvA-5oqrA:
undetectable		 2egvA-5oqrA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tjz 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE

(Mycobacterium
tuberculosis) 		no annotation 5 LEU A 100
VAL A  73
LEU A 241
LEU A 223
ALA A 224
 None
None
None
SO4  A 315 (-3.8A)
None
 1.06A 2egvA-5tjzA:
2.9		 2egvA-5tjzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vba LYSOZYME, ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPG1
CHIMERA

(Mycobacterium
kansasii;
Escherichia
virus T4) 		PF00959
(Phage_lysozyme)
PF14011
(ESX-1_EspG) 		5 LEU A1039
GLY A1023
THR A1026
LEU A1033
ALA A1042
 None
 1.01A 2egvA-5vbaA:
undetectable		 2egvA-5vbaA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x06 DNAA REGULATORY
INACTIVATOR HDA

(Escherichia
coli) 		no annotation 5 LEU E  98
VAL E  74
LEU E 132
LEU E 133
LEU E  60
 None
 0.97A 2egvA-5x06E:
undetectable		 2egvA-5x06E:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c4q POLYKETIDE SYNTHASE
PKS13

(Mycobacterium
tuberculosis) 		no annotation 5 LEU A  27
THR A  83
LEU A  87
THR A  89
ALA A  88
 None
 1.09A 2egvA-6c4qA:
undetectable		 2egvA-6c4qA:
undetectable