SIMILAR PATTERNS OF AMINO ACIDS FOR 2E7F_B_C2FB4000_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d8c MALATE SYNTHASE G

(Escherichia
coli) 		PF01274
(Malate_synthase) 		5 ILE A 642
LEU A 596
GLY A 602
GLN A 670
ILE A 603
 None
 1.22A 2e7fB-1d8cA:
8.5		 2e7fB-1d8cA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d8c MALATE SYNTHASE G

(Escherichia
coli) 		PF01274
(Malate_synthase) 		5 MET A 680
ILE A 642
LEU A 596
GLY A 602
ILE A 603
 None
 1.33A 2e7fB-1d8cA:
8.5		 2e7fB-1d8cA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dnp DNA PHOTOLYASE

(Escherichia
coli) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		5 ILE A  54
LEU A  53
GLY A 244
GLN A 250
ARG A 249
 None
 1.32A 2e7fB-1dnpA:
undetectable		 2e7fB-1dnpA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6y METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT

(Methanosarcina
barkeri) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		5 ILE B2420
LEU B2110
GLY B2414
SER B2410
ILE B2200
 None
 1.17A 2e7fB-1e6yB:
undetectable		 2e7fB-1e6yB:
18.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1f6y 5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE

(Moorella
thermoacetica) 		PF00809
(Pterin_bind) 		11 GLU A   6
MET A  11
PHE A  12
ASN A  96
ILE A 120
LEU A 122
GLY A 196
SER A 198
GLN A 202
ARG A 207
ILE A 227
 None
 0.64A 2e7fB-1f6yA:
45.4		 2e7fB-1f6yA:
99.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1f6y 5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE

(Moorella
thermoacetica) 		PF00809
(Pterin_bind) 		5 GLU A   6
MET A  11
PHE A  12
LEU A 162
ILE A 227
 None
 1.13A 2e7fB-1f6yA:
45.4		 2e7fB-1f6yA:
99.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1f6y 5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE

(Moorella
thermoacetica) 		PF00809
(Pterin_bind) 		7 MET A  11
PHE A  12
LEU A 122
SER A 198
ASN A 199
GLN A 202
ARG A 207
 None
 1.03A 2e7fB-1f6yA:
45.4		 2e7fB-1f6yA:
99.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ii0 ARSENICAL
PUMP-DRIVING ATPASE

(Escherichia
coli) 		PF02374
(ArsA_ATPase) 		5 GLU A  75
ILE A  65
GLY A  51
ASN A  49
ILE A  58
 None
None
None
ADP  A 590 ( 4.8A)
None
 1.02A 2e7fB-1ii0A:
undetectable		 2e7fB-1ii0A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k3g CYTOCHROME C-553

(Sporosarcina
pasteurii) 		PF13442
(Cytochrome_CBB3) 		5 GLU A  57
ILE A  48
LEU A  40
GLY A  52
ILE A  60
 None
HEC  A  93 (-3.8A)
None
None
HEC  A  93 (-3.5A)
 1.26A 2e7fB-1k3gA:
undetectable		 2e7fB-1k3gA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lq2 BETA-D-GLUCAN
GLUCOHYDROLASE
ISOENZYME EXO1

(Hordeum vulgare) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		5 ILE A 177
LEU A 180
SER A 162
ASN A 112
ILE A 148
 None
 1.14A 2e7fB-1lq2A:
9.4		 2e7fB-1lq2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 ILE A 866
LEU A1193
GLY A1111
ARG A 837
ILE A1177
 None
 1.25A 2e7fB-1ofeA:
7.9		 2e7fB-1ofeA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 ILE A1056
LEU A1035
GLY A1047
SER A 208
ARG A 206
 None
None
None
None
ONL  A2511 (-4.0A)
 1.26A 2e7fB-1ofeA:
7.9		 2e7fB-1ofeA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofu CELL DIVISION
PROTEIN FTSZ

(Pseudomonas
aeruginosa) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 GLU A 139
PHE A 183
ILE A 151
LEU A 154
GLY A 106
 GDP  A1318 (-2.8A)
GDP  A1318 (-3.8A)
None
None
GDP  A1318 ( 4.3A)
 1.31A 2e7fB-1ofuA:
2.7		 2e7fB-1ofuA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		5 ILE A 533
LEU A 543
GLY A 250
SER A 163
ILE A 249
 None
 1.25A 2e7fB-1ps9A:
9.1		 2e7fB-1ps9A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgz PROTEIN
(FERREDOXIN:NADP+
REDUCTASE)

(Nostoc sp. PCC
7119) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		5 ILE A 159
LEU A 189
GLY A 192
SER A 223
GLN A 226
 None
None
None
SO4  A 307 (-2.6A)
None
 1.18A 2e7fB-1qgzA:
undetectable		 2e7fB-1qgzA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rlh CONSERVED
HYPOTHETICAL PROTEIN

(Thermoplasma
acidophilum) 		PF04008
(Adenosine_kin) 		5 ILE A 110
LEU A 108
GLY A  12
SER A  99
GLN A  95
 None
 1.28A 2e7fB-1rlhA:
undetectable		 2e7fB-1rlhA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5u ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		no annotation 5 GLU A 140
ILE A  24
LEU A  20
ASN A   5
ARG A 229
 None
 1.20A 2e7fB-1u5uA:
undetectable		 2e7fB-1u5uA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5c CHITOSANASE

(Bacillus sp.
(in: Bacteria)) 		PF01270
(Glyco_hydro_8) 		5 PHE A 293
ASN A 223
ILE A 219
LEU A 163
GLY A 184
 None
 1.24A 2e7fB-1v5cA:
undetectable		 2e7fB-1v5cA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
RE-EXPORTER

(Saccharomyces
cerevisiae) 		PF03378
(CAS_CSE1)
PF03810
(IBN_N)
PF08506
(Cse1) 		5 GLU C 107
ILE C  44
LEU C  41
SER C 110
ARG C 153
 None
 1.16A 2e7fB-1wa5C:
undetectable		 2e7fB-1wa5C:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1b CRTF-RELATED PROTEIN

(Chlorobaculum
tepidum) 		PF00891
(Methyltransf_2) 		5 GLU A 147
ASN A  98
ILE A 158
GLY A 181
ASN A 211
 SAH  A4261 (-2.7A)
None
None
None
None
 1.27A 2e7fB-1x1bA:
undetectable		 2e7fB-1x1bA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yve ACETOHYDROXY ACID
ISOMEROREDUCTASE

(Spinacia
oleracea) 		PF01450
(IlvC)
PF07991
(IlvN) 		5 LEU I 224
GLY I 231
SER I 235
GLN I 238
ILE I 412
 None
 1.31A 2e7fB-1yveI:
undetectable		 2e7fB-1yveI:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bej SEGREGATION PROTEIN

(Thermus
thermophilus) 		PF13614
(AAA_31) 		5 GLU A 241
ILE A   9
LEU A  11
GLY A 173
ARG A 194
 None
 1.22A 2e7fB-2bejA:
3.0		 2e7fB-2bejA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2de2 DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME B

(Rhodococcus sp.
IGTS8) 		no annotation 5 GLU A 156
PHE A 103
GLY A 183
SER A 181
GLN A 210
 None
None
GOL  A 501 (-3.3A)
None
None
 1.21A 2e7fB-2de2A:
undetectable		 2e7fB-2de2A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f4o PEPTIDE N-GLYCANASE
XP-C REPAIR
COMPLEMENTING
COMPLEX 58 KDA
PROTEIN

(Mus musculus;
Mus musculus) 		PF01841
(Transglut_core)
PF09280
(XPC-binding) 		5 ILE A 176
LEU A 172
GLY A 413
ASN A 412
GLN B 290
 None
 1.32A 2e7fB-2f4oA:
undetectable		 2e7fB-2f4oA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g02 NISIN BIOSYNTHESIS
PROTEIN NISC

(Lactococcus
lactis) 		PF05147
(LANC_like) 		5 PHE A  34
ILE A  98
GLY A  93
SER A  86
ILE A  94
 None
 1.26A 2e7fB-2g02A:
undetectable		 2e7fB-2g02A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0m PHOSPHATE TRANSPORT
SYSTEM PROTEIN PHOU

(Streptococcus
pneumoniae) 		PF01895
(PhoU) 		5 ILE A 187
GLY A 180
SER A 176
ASN A 179
ILE A 166
 None
 1.21A 2e7fB-2i0mA:
undetectable		 2e7fB-2i0mA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j13 POLYSACCHARIDE
DEACETYLASE

(Bacillus
anthracis) 		PF01522
(Polysacc_deac_1) 		5 GLU A 121
PHE A 110
LEU A  90
GLY A  80
SER A 106
 None
 1.22A 2e7fB-2j13A:
3.1		 2e7fB-2j13A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyy IONOTROPIC GLUTAMATE
RECEPTOR BACTERIAL
HOMOLOGUE

(Nostoc
punctiforme) 		PF00497
(SBP_bac_3) 		5 PHE A 219
ILE A 198
LEU A  64
GLY A 185
ILE A  85
 None
 1.32A 2e7fB-2pyyA:
undetectable		 2e7fB-2pyyA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vaw CELL DIVISION
PROTEIN FTSZ

(Pseudomonas
aeruginosa) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 GLU A 139
PHE A 183
ILE A 151
LEU A 154
GLY A 106
 GDP  A1317 (-2.4A)
GDP  A1317 (-4.5A)
None
None
GDP  A1317 ( 4.0A)
 1.26A 2e7fB-2vawA:
2.7		 2e7fB-2vawA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C)
PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C) 		5 PHE A 475
ASN A 561
LEU A 613
GLY A 595
ILE A 559
 None
 1.28A 2e7fB-2vcaA:
8.4		 2e7fB-2vcaA:
13.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ycj 5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE

(Carboxydothermus
hydrogenoformans) 		PF00809
(Pterin_bind) 		11 GLU A   7
PHE A  13
ASN A  97
ILE A 121
LEU A 123
GLY A 197
SER A 199
ASN A 200
GLN A 203
ARG A 208
ILE A 228
 C2F  A3000 ( 4.1A)
C2F  A3000 (-3.9A)
C2F  A3000 (-3.0A)
C2F  A3000 ( 4.2A)
None
C2F  A3000 (-3.6A)
GOL  A1270 ( 3.9A)
C2F  A3000 (-3.1A)
C2F  A3000 (-3.9A)
C2F  A3000 ( 2.6A)
C2F  A3000 (-4.6A)
 0.38A 2e7fB-2ycjA:
43.2		 2e7fB-2ycjA:
60.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ycj 5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE

(Carboxydothermus
hydrogenoformans) 		PF00809
(Pterin_bind) 		5 GLU A   7
PHE A  13
LEU A 163
GLY A 197
ILE A 228
 C2F  A3000 ( 4.1A)
C2F  A3000 (-3.9A)
None
C2F  A3000 (-3.6A)
C2F  A3000 (-4.6A)
 1.11A 2e7fB-2ycjA:
43.2		 2e7fB-2ycjA:
60.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Mus musculus) 		PF11921
(DUF3439)
PF13306
(LRR_5)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 ILE A 165
LEU A 186
GLY A 157
ASN A 158
ILE A 156
 None
 1.32A 2e7fB-2z81A:
undetectable		 2e7fB-2z81A:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a18 ALDOXIME DEHYDRATASE

(Rhodococcus
erythropolis) 		PF13816
(Dehydratase_hem) 		5 GLY A 281
SER A 260
ASN A 261
ARG A 345
ILE A 280
 None
 1.26A 2e7fB-3a18A:
undetectable		 2e7fB-3a18A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1f PUTATIVE PREPHENATE
DEHYDROGENASE

(Streptococcus
mutans) 		PF02153
(PDH) 		5 PHE A  79
ILE A  22
LEU A 166
GLY A  15
ILE A   8
 None
 1.13A 2e7fB-3b1fA:
undetectable		 2e7fB-3b1fA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bit FACT COMPLEX SUBUNIT
SPT16

(Saccharomyces
cerevisiae) 		PF00557
(Peptidase_M24)
PF14826
(FACT-Spt16_Nlob) 		5 ILE A 225
LEU A 231
GLY A 190
SER A 188
ILE A 292
 None
 1.13A 2e7fB-3bitA:
undetectable		 2e7fB-3bitA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bol 5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE

(Thermotoga
maritima) 		PF00809
(Pterin_bind)
PF02574
(S-methyl_trans) 		6 ASN A 411
ILE A 435
LEU A 437
GLY A 505
SER A 507
ASN A 508
 None
 0.98A 2e7fB-3bolA:
26.3		 2e7fB-3bolA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bol 5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE

(Thermotoga
maritima) 		PF00809
(Pterin_bind)
PF02574
(S-methyl_trans) 		7 GLU A 320
ASN A 411
ILE A 435
LEU A 437
GLY A 505
SER A 507
ILE A 536
 None
 0.67A 2e7fB-3bolA:
26.3		 2e7fB-3bolA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		5 GLU A 140
ILE A  24
LEU A  20
ASN A   5
ARG A 229
 None
 1.21A 2e7fB-3dy5A:
undetectable		 2e7fB-3dy5A:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3elk PUTATIVE
TRANSCRIPTIONAL
REGULATOR TA0346

(Thermoplasma
acidophilum) 		PF03551
(PadR) 		5 ILE A  19
LEU A  23
GLY A  30
GLN A  75
ILE A  50
 None
 1.15A 2e7fB-3elkA:
undetectable		 2e7fB-3elkA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gm8 GLYCOSIDE HYDROLASE
FAMILY 2, CANDIDATE
BETA-GLYCOSIDASE

(Bacteroides
vulgatus) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		5 GLU A 490
ILE A 462
LEU A 459
GLY A 441
ARG A 159
 GOL  A   1 (-2.5A)
None
None
None
GOL  A   1 (-3.0A)
 1.25A 2e7fB-3gm8A:
5.8		 2e7fB-3gm8A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jz4 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
[NADP+]

(Escherichia
coli) 		PF00171
(Aldedh) 		5 GLU A 235
ILE A 152
LEU A 228
GLY A 237
ILE A 236
 None
NAP  A 482 ( 4.2A)
None
None
NAP  A 482 (-3.6A)
 0.98A 2e7fB-3jz4A:
undetectable		 2e7fB-3jz4A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k13 5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE

(Bacteroides
thetaiotaomicron) 		PF00809
(Pterin_bind) 		7 GLU A 358
ASN A 452
GLY A 558
SER A 560
ASN A 561
ARG A 573
ILE A 593
 THH  A 642 ( 3.5A)
THH  A 642 (-3.0A)
THH  A 642 (-3.3A)
K  A 644 ( 3.4A)
THH  A 642 ( 3.3A)
THH  A 642 (-3.1A)
THH  A 642 (-4.2A)
 0.26A 2e7fB-3k13A:
29.8		 2e7fB-3k13A:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kd8 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Thermoplasma
acidophilum) 		PF01676
(Metalloenzyme)
PF10143
(PhosphMutase) 		5 ILE A 390
GLY A  44
SER A 375
ASN A  43
ILE A 355
 None
 1.29A 2e7fB-3kd8A:
undetectable		 2e7fB-3kd8A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lop SUBSTRATE BINDING
PERIPLASMIC PROTEIN

(Ralstonia
solanacearum) 		PF13458
(Peripla_BP_6) 		5 GLU A 318
LEU A 346
GLY A 134
GLN A  40
ILE A 151
 None
 1.26A 2e7fB-3lopA:
3.6		 2e7fB-3lopA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ohm 1-PHOSPHATIDYLINOSIT
OL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3

(Homo sapiens) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		5 PHE B 805
LEU B 313
GLY B 688
ASN B 830
ILE B 810
 None
 1.32A 2e7fB-3ohmB:
7.0		 2e7fB-3ohmB:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oox PUTATIVE 2OG-FE(II)
OXYGENASE FAMILY
PROTEIN

(Caulobacter
vibrioides) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		5 ILE A 148
LEU A 145
GLY A 231
ASN A 194
ILE A 230
 None
 1.33A 2e7fB-3ooxA:
undetectable		 2e7fB-3ooxA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3orq N5-CARBOXYAMINOIMIDA
ZOLE RIBONUCLEOTIDE
SYNTHETASE

(Staphylococcus
aureus) 		PF02222
(ATP-grasp)
PF02826
(2-Hacid_dh_C) 		5 GLU A 254
PHE A 256
LEU A 316
GLN A 159
ARG A 108
 MG  A 375 ( 2.4A)
ADP  A 376 (-4.5A)
None
ADP  A 376 (-3.6A)
ADP  A 376 (-3.2A)
 1.18A 2e7fB-3orqA:
undetectable		 2e7fB-3orqA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0o CARNITINYL-COA
DEHYDRATASE

(Mycobacterium
avium) 		PF00378
(ECH_1) 		6 ILE A  24
LEU A  23
GLY A  63
SER A  68
ASN A 111
ILE A  26
 None
 1.49A 2e7fB-3r0oA:
undetectable		 2e7fB-3r0oA:
26.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rh9 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(NAD(P)(+))

(Marinobacter
hydrocarbonoclasticus) 		PF00171
(Aldedh) 		5 MET A 188
PHE A 192
LEU A 240
GLY A 150
SER A 176
 None
 1.28A 2e7fB-3rh9A:
undetectable		 2e7fB-3rh9A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufc PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF01881
(Cas_Cas6) 		5 GLU X  95
ILE X  28
LEU X  43
GLY X  93
ILE X  94
 None
 1.22A 2e7fB-3ufcX:
undetectable		 2e7fB-3ufcX:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8b PUTATIVE
DEHYDROGENASE,
POSSIBLY
3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		5 ILE A 234
LEU A  25
GLY A  18
SER A  15
ILE A  17
 None
 1.26A 2e7fB-3v8bA:
2.1		 2e7fB-3v8bA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w08 ALDOXIME DEHYDRATASE

(Pseudomonas
chlororaphis) 		PF13816
(Dehydratase_hem) 		5 GLY A 281
SER A 260
ASN A 261
ARG A 345
ILE A 280
 None
 1.28A 2e7fB-3w08A:
undetectable		 2e7fB-3w08A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5v FERREDOXIN

(Zea mays) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		5 ILE A 174
LEU A 200
GLY A 203
SER A 234
GLN A 237
 None
 1.17A 2e7fB-3w5vA:
undetectable		 2e7fB-3w5vA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4afr METACASPASE

(Trypanosoma
brucei) 		PF00656
(Peptidase_C14) 		5 MET A 254
ILE A  80
GLY A 159
SER A 215
ILE A 176
 None
 1.27A 2e7fB-4afrA:
undetectable		 2e7fB-4afrA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c23 L-FUCULOSE KINASE
FUCK

(Streptococcus
pneumoniae) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 ILE A  56
LEU A   9
GLY A  73
ASN A 432
ILE A  72
 None
 1.21A 2e7fB-4c23A:
undetectable		 2e7fB-4c23A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccz METHIONINE SYNTHASE

(Homo sapiens) 		PF00809
(Pterin_bind)
PF02574
(S-methyl_trans) 		7 GLU A 376
ASN A 470
GLY A 576
SER A 578
ASN A 579
ARG A 591
ILE A 611
 THG  A1652 (-3.5A)
THG  A1652 (-3.2A)
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
THG  A1652 (-3.1A)
THG  A1652 (-3.0A)
THG  A1652 (-4.2A)
 0.39A 2e7fB-4cczA:
30.1		 2e7fB-4cczA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cdb LISTERIOLYSIN O

(Listeria
monocytogenes) 		PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C) 		5 PHE A 464
ILE A 477
SER A 454
ASN A 456
ILE A 468
 None
 1.08A 2e7fB-4cdbA:
undetectable		 2e7fB-4cdbA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4drt DE NOVO DESIGNED
SERINE HYDROLASE,
OR89

(synthetic
construct) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		5 ILE A 237
LEU A 257
GLY A 212
ASN A 200
ILE A 213
 None
 1.20A 2e7fB-4drtA:
undetectable		 2e7fB-4drtA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e6e CELL DIVISION
PROTEIN FTSZ

(Thermobifida
fusca) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 GLU A 136
PHE A 180
ILE A 148
LEU A 151
GLY A 103
 None
 1.27A 2e7fB-4e6eA:
2.6		 2e7fB-4e6eA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f52 GLOMULIN

(Homo sapiens) 		PF08568
(Kinetochor_Ybp2) 		5 GLU E  38
ILE E  89
LEU E  93
GLY E  33
ILE E  37
 None
 1.08A 2e7fB-4f52E:
undetectable		 2e7fB-4f52E:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f92 U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		5 GLU B 890
PHE B 416
ILE B 617
LEU B 665
ILE B 889
 None
 1.17A 2e7fB-4f92B:
undetectable		 2e7fB-4f92B:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g8d ALPHA/BETA HYDROLASE
FOLD PROTEIN

(Ochrobactrum
sp. T63) 		PF00561
(Abhydrolase_1) 		5 PHE A 138
ILE A 211
LEU A 235
ASN A 215
ILE A 123
 None
 1.32A 2e7fB-4g8dA:
undetectable		 2e7fB-4g8dA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gba DCN1-LIKE PROTEIN 3

(Homo sapiens) 		PF03556
(Cullin_binding) 		5 PHE A 270
ASN A 231
GLY A 237
SER A 239
ILE A 235
 None
 1.12A 2e7fB-4gbaA:
undetectable		 2e7fB-4gbaA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gnk 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3

(Homo sapiens) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		5 PHE B 805
LEU B 308
GLY B 688
ASN B 830
ILE B 810
 None
 1.32A 2e7fB-4gnkB:
6.9		 2e7fB-4gnkB:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9d ADENYLOSUCCINATE
SYNTHETASE

(Bacillus
anthracis) 		PF00709
(Adenylsucc_synt) 		6 GLU A 295
ILE A 337
LEU A 340
GLY A 307
SER A 270
GLN A  10
 None
 1.44A 2e7fB-4m9dA:
undetectable		 2e7fB-4m9dA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9d ADENYLOSUCCINATE
SYNTHETASE

(Bacillus
anthracis) 		PF00709
(Adenylsucc_synt) 		6 GLU A 295
ILE A 337
LEU A 340
SER A 270
GLN A  10
ILE A 289
 None
 1.21A 2e7fB-4m9dA:
undetectable		 2e7fB-4m9dA:
18.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o1e DIHYDROPTEROATE
SYNTHASE DHPS

(Desulfitobacterium
hafniense) 		PF00809
(Pterin_bind) 		6 ASN A  97
ILE A 121
GLY A 196
SER A 198
ARG A 207
ILE A 227
 C2F  A3000 (-3.0A)
C2F  A3000 ( 4.1A)
C2F  A3000 (-3.5A)
C2F  A3000 ( 3.8A)
None
C2F  A3000 (-4.3A)
 1.10A 2e7fB-4o1eA:
34.0		 2e7fB-4o1eA:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o1e DIHYDROPTEROATE
SYNTHASE DHPS

(Desulfitobacterium
hafniense) 		PF00809
(Pterin_bind) 		7 ASN A  97
ILE A 121
LEU A 123
GLY A 196
ASN A 199
ARG A 207
ILE A 227
 C2F  A3000 (-3.0A)
C2F  A3000 ( 4.1A)
None
C2F  A3000 (-3.5A)
C2F  A3000 ( 4.3A)
None
C2F  A3000 (-4.3A)
 0.84A 2e7fB-4o1eA:
34.0		 2e7fB-4o1eA:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o1e DIHYDROPTEROATE
SYNTHASE DHPS

(Desulfitobacterium
hafniense) 		PF00809
(Pterin_bind) 		6 GLU A   7
ASN A  97
ILE A 121
LEU A 123
GLY A 196
ILE A 227
 C2F  A3000 (-3.6A)
C2F  A3000 (-3.0A)
C2F  A3000 ( 4.1A)
None
C2F  A3000 (-3.5A)
C2F  A3000 (-4.3A)
 0.50A 2e7fB-4o1eA:
34.0		 2e7fB-4o1eA:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oen SECOND SUBSTRATE
BINDING DOMAIN OF
PUTATIVE AMINO ACID
ABC TRANSPORTER

(Streptococcus
pneumoniae) 		PF00497
(SBP_bac_3) 		5 PHE A 277
ASN A 354
GLY A 447
SER A 335
ILE A 446
 ACT  A 507 (-3.4A)
None
None
ACT  A 506 (-3.4A)
None
 1.31A 2e7fB-4oenA:
undetectable		 2e7fB-4oenA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oua LATENT FORM OF PPO4
TYROSINASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		5 PHE B 257
ILE B 522
GLY B 475
ASN B 245
ILE B 451
 None
 1.31A 2e7fB-4ouaB:
undetectable		 2e7fB-4ouaB:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p63 PROBABLE
DEOXYHYPUSINE
SYNTHASE

(Pyrococcus
horikoshii) 		PF01916
(DS) 		5 GLU A 106
ILE A 235
LEU A 233
GLY A 218
SER A 216
 NAD  A 401 (-3.5A)
None
None
None
None
 1.10A 2e7fB-4p63A:
undetectable		 2e7fB-4p63A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pe5 GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 MET B 789
PHE B 784
ILE B 408
LEU B 478
ILE B 764
 None
 1.23A 2e7fB-4pe5B:
undetectable		 2e7fB-4pe5B:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q22 GLYCOSIDE HYDROLASE
FAMILY 18

(Serratia
proteamaculans) 		PF00704
(Glyco_hydro_18) 		5 GLU A 372
LEU A 389
SER A 376
GLN A 352
ILE A 273
 None
 1.32A 2e7fB-4q22A:
5.2		 2e7fB-4q22A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3

(Homo sapiens) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		5 PHE B 805
LEU B 313
GLY B 688
ASN B 830
ILE B 810
 None
 1.32A 2e7fB-4qj4B:
3.5		 2e7fB-4qj4B:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgk UNCHARACTERIZED
PROTEIN

(Yersinia pestis) 		PF07350
(DUF1479) 		5 ILE A  46
LEU A  50
SER A 341
ASN A 272
ILE A 274
 None
 1.29A 2e7fB-4rgkA:
undetectable		 2e7fB-4rgkA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s2t PROTEIN APP-1

(Caenorhabditis
elegans) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		5 ILE P 502
LEU P 513
SER P 558
ARG P 588
ILE P 521
 None
None
SO4  P 704 (-4.9A)
SO4  P 704 (-4.0A)
None
 1.30A 2e7fB-4s2tP:
undetectable		 2e7fB-4s2tP:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2x ENDO-BETA-1,4-GLUCAN
ASE (CELLULASE B)

(Bacillus
halodurans) 		PF00150
(Cellulase)
PF03442
(CBM_X2) 		5 ILE A 428
SER A 370
GLN A 310
ARG A 265
ILE A 373
 None
 1.28A 2e7fB-4v2xA:
12.6		 2e7fB-4v2xA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xqk LLABIII

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII)
PF13156
(Mrr_cat_2) 		5 GLU A 958
PHE A 936
ILE A 845
ARG A1003
ILE A 955
 None
 1.21A 2e7fB-4xqkA:
undetectable		 2e7fB-4xqkA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a42 UNCHARACTERIZED
LIPOPROTEIN YFHM

(Escherichia
coli) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF11974
(MG1) 		5 ILE A 422
LEU A 424
GLY A 407
ASN A 406
GLN A 971
 None
 1.18A 2e7fB-5a42A:
undetectable		 2e7fB-5a42A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
GAMMA

(Methanothermobacter
marburgensis) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		5 ILE B 422
LEU B 113
GLY B 416
SER B 412
ILE B 203
 None
 1.09A 2e7fB-5a8rB:
undetectable		 2e7fB-5a8rB:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 PHE A 298
ILE A 251
LEU A 231
GLY A 218
SER A 284
 None
None
None
FAD  A 701 (-3.1A)
FAD  A 701 (-3.6A)
 1.03A 2e7fB-5ahkA:
2.8		 2e7fB-5ahkA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dqp EDTA MONOOXYGENASE

(EDTA-degrading
bacterium BNC1) 		PF00296
(Bac_luciferase) 		5 ILE A  82
LEU A  55
GLY A  90
ARG A   5
ILE A  89
 None
 1.19A 2e7fB-5dqpA:
7.2		 2e7fB-5dqpA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dqp EDTA MONOOXYGENASE

(EDTA-degrading
bacterium BNC1) 		PF00296
(Bac_luciferase) 		5 PHE A 409
ILE A  82
LEU A  55
GLY A  90
ILE A  89
 None
 1.26A 2e7fB-5dqpA:
7.2		 2e7fB-5dqpA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epg ALDEHYDE OXIDASE

(Homo sapiens) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 ASN A  72
GLY A 346
ASN A 436
ARG A 429
ILE A 349
 FES  A3002 ( 3.8A)
None
None
FAD  A3004 (-4.1A)
FAD  A3004 ( 4.3A)
 1.22A 2e7fB-5epgA:
undetectable		 2e7fB-5epgA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey8 ACYL-COA SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00501
(AMP-binding) 		5 GLU A 347
PHE A 442
ILE A 480
LEU A 478
GLY A 344
 None
None
5SV  A 701 (-3.6A)
None
5SV  A 701 (-3.6A)
 1.29A 2e7fB-5ey8A:
undetectable		 2e7fB-5ey8A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey9 LONG-CHAIN-FATTY-ACI
D--AMP LIGASE FADD32

(Mycobacterium
marinum) 		PF00501
(AMP-binding) 		5 GLU A 346
PHE A 441
ILE A 479
LEU A 477
GLY A 343
 None
None
5SV  A 701 (-4.0A)
None
5SV  A 701 (-3.8A)
 1.31A 2e7fB-5ey9A:
undetectable		 2e7fB-5ey9A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g2v N-ACETYLGLUCOSAMINE-
6-SULFATASE

(Bacteroides
thetaiotaomicron) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		5 ILE A 344
LEU A 333
GLY A 327
ARG A 207
ILE A 326
 None
 0.94A 2e7fB-5g2vA:
undetectable		 2e7fB-5g2vA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gnd PUTATIVE SERINE
PROTEASE HHOA

(Synechocystis
sp. PCC 6803) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 GLU A 247
ILE A 226
LEU A 209
ASN A 181
ILE A 249
 None
 0.95A 2e7fB-5gndA:
undetectable		 2e7fB-5gndA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i4d SUPERANTIGEN-LIKE
PROTEIN

(Staphylococcus
aureus) 		PF02876
(Stap_Strp_tox_C)
PF09199
(SSL_OB) 		5 GLU A 262
ILE A 283
LEU A 293
SER A 264
ARG A 276
 None
 1.22A 2e7fB-5i4dA:
undetectable		 2e7fB-5i4dA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ksd ATPASE 2, PLASMA
MEMBRANE-TYPE

(Arabidopsis
thaliana) 		PF00122
(E1-E2_ATPase)
PF00690
(Cation_ATPase_N)
PF00702
(Hydrolase) 		5 GLU A 319
ILE A 628
LEU A 620
GLY A 602
ILE A 601
 None
 1.09A 2e7fB-5ksdA:
undetectable		 2e7fB-5ksdA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m59 PRE-MRNA SPLICING
HELICASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		5 GLU A 940
PHE A 465
ILE A 665
LEU A 713
ILE A 939
 None
 1.10A 2e7fB-5m59A:
2.1		 2e7fB-5m59A:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5p PRE-MRNA-SPLICING
HELICASE BRR2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		5 GLU A 909
PHE A 434
ILE A 636
LEU A 684
ILE A 908
 None
 1.23A 2e7fB-5m5pA:
undetectable		 2e7fB-5m5pA:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v0i TRYPTOPHAN--TRNA
LIGASE

(Escherichia
coli) 		PF00579
(tRNA-synt_1b) 		5 GLU A 211
ILE A 249
LEU A 246
SER A 215
ILE A 207
 None
 1.23A 2e7fB-5v0iA:
undetectable		 2e7fB-5v0iA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE

(Thermus
thermophilus) 		no annotation 8 GLU A 373
ASN A 464
LEU A 492
GLY A 570
SER A 572
ASN A 573
ARG A 583
ILE A 603
 C2F  A3001 (-3.7A)
C2F  A3001 (-2.2A)
None
C2F  A3001 (-3.5A)
C2F  A3001 ( 4.5A)
C2F  A3001 (-2.6A)
C2F  A3001 (-3.0A)
C2F  A3001 (-3.5A)
 0.26A 2e7fB-5vopA:
30.8		 2e7fB-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xni MCYF

(Microcystis
aeruginosa) 		no annotation 5 PHE A 137
ILE A  83
LEU A   8
GLY A  86
ILE A  85
 None
 1.18A 2e7fB-5xniA:
undetectable		 2e7fB-5xniA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5i RETINAL
DEHYDROGENASE 2

(Homo sapiens) 		no annotation 5 MET A 123
ILE A 197
LEU A 109
GLY A 223
ILE A 238
 None
 1.21A 2e7fB-6b5iA:
undetectable		 2e7fB-6b5iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c43 GAMMA-AMINOBUTYRALDE
HYDE DEHYDROGENASE

(Salmonella
enterica) 		no annotation 5 ILE A 386
LEU A 296
GLY A 301
ASN A 302
ILE A 347
 None
 1.18A 2e7fB-6c43A:
undetectable		 2e7fB-6c43A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6chs PUTATIVE CELL
DIVISION CONTROL
PROTEIN

(Chaetomium
thermophilum) 		no annotation 5 MET H 404
ILE H 222
LEU H 269
GLY H 424
ILE H 396
 None
None
AGS  H 901 (-4.4A)
AGS  H 901 (-3.5A)
AGS  H 901 ( 4.2A)
 1.20A 2e7fB-6chsH:
2.3		 2e7fB-6chsH:
undetectable