SIMILAR PATTERNS OF AMINO ACIDS FOR 2E7F_A_C2FA3000_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bkh MUCONATE LACTONIZING
ENZYME

(Pseudomonas
putida) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLU A 256
ILE A 295
LEU A 297
SER A 254
ASN A 277
 None
 1.13A 2e7fA-1bkhA:
8.4		 2e7fA-1bkhA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d8c MALATE SYNTHASE G

(Escherichia
coli) 		PF01274
(Malate_synthase) 		5 MET A 680
ILE A 642
LEU A 596
GLY A 602
ILE A 603
 None
 1.31A 2e7fA-1d8cA:
8.0		 2e7fA-1d8cA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6y METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT

(Methanosarcina
barkeri) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		5 ILE B2420
LEU B2110
GLY B2414
SER B2410
ILE B2200
 None
 1.21A 2e7fA-1e6yB:
undetectable		 2e7fA-1e6yB:
18.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1f6y 5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE

(Moorella
thermoacetica) 		PF00809
(Pterin_bind) 		11 GLU A   6
MET A  11
PHE A  12
ASP A  75
ASN A  96
ILE A 120
LEU A 122
GLY A 196
SER A 198
ARG A 207
ILE A 227
 None
 0.38A 2e7fA-1f6yA:
45.7		 2e7fA-1f6yA:
99.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1f6y 5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE

(Moorella
thermoacetica) 		PF00809
(Pterin_bind) 		5 GLU A   6
MET A  11
PHE A  12
LEU A 162
ILE A 227
 None
 1.13A 2e7fA-1f6yA:
45.7		 2e7fA-1f6yA:
99.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1f6y 5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE

(Moorella
thermoacetica) 		PF00809
(Pterin_bind) 		6 MET A  11
PHE A  12
LEU A 122
SER A 198
ASN A 199
ARG A 207
 None
 0.91A 2e7fA-1f6yA:
45.7		 2e7fA-1f6yA:
99.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ii0 ARSENICAL
PUMP-DRIVING ATPASE

(Escherichia
coli) 		PF02374
(ArsA_ATPase) 		5 GLU A  75
ILE A  65
GLY A  51
ASN A  49
ILE A  58
 None
None
None
ADP  A 590 ( 4.8A)
None
 1.12A 2e7fA-1ii0A:
undetectable		 2e7fA-1ii0A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k3g CYTOCHROME C-553

(Sporosarcina
pasteurii) 		PF13442
(Cytochrome_CBB3) 		5 GLU A  57
ILE A  48
LEU A  40
GLY A  52
ILE A  60
 None
HEC  A  93 (-3.8A)
None
None
HEC  A  93 (-3.5A)
 1.29A 2e7fA-1k3gA:
undetectable		 2e7fA-1k3gA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lq2 BETA-D-GLUCAN
GLUCOHYDROLASE
ISOENZYME EXO1

(Hordeum vulgare) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		5 ILE A 177
LEU A 180
SER A 162
ASN A 112
ILE A 148
 None
 1.13A 2e7fA-1lq2A:
9.2		 2e7fA-1lq2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 ILE A 866
LEU A1193
GLY A1111
ARG A 837
ILE A1177
 None
 1.27A 2e7fA-1ofeA:
7.5		 2e7fA-1ofeA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 ILE A1056
LEU A1035
GLY A1047
SER A 208
ARG A 206
 None
None
None
None
ONL  A2511 (-4.0A)
 1.25A 2e7fA-1ofeA:
7.5		 2e7fA-1ofeA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1poy SPERMIDINE/PUTRESCIN
E-BINDING PROTEIN

(Escherichia
coli) 		PF13416
(SBP_bac_8) 		5 GLU 1  36
LEU 1 304
GLY 1 292
SER 1 232
ILE 1 291
 SPD  1 400 (-3.5A)
None
None
None
None
 1.25A 2e7fA-1poy1:
undetectable		 2e7fA-1poy1:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ps9 2,4-DIENOYL-COA
REDUCTASE

(Escherichia
coli) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		5 ILE A 533
LEU A 543
GLY A 250
SER A 163
ILE A 249
 None
 1.26A 2e7fA-1ps9A:
9.1		 2e7fA-1ps9A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tjy SUGAR TRANSPORT
PROTEIN

(Salmonella
enterica) 		PF13407
(Peripla_BP_4) 		5 ASP A 118
ILE A 128
GLY A 320
ASN A 319
ILE A 321
 None
 1.04A 2e7fA-1tjyA:
2.2		 2e7fA-1tjyA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tww DHPS,
DIHYDROPTEROATE
SYNTHASE

(Bacillus
anthracis) 		PF00809
(Pterin_bind) 		5 ASP A 101
ASN A 120
ILE A 143
GLY A 216
SER A 218
 HH2  A 282 (-3.4A)
HH2  A 282 (-2.7A)
HH2  A 282 (-4.1A)
HH2  A 282 (-3.3A)
None
 0.63A 2e7fA-1twwA:
23.3		 2e7fA-1twwA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5u ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		no annotation 5 GLU A 140
ILE A  24
LEU A  20
ASN A   5
ARG A 229
 None
 1.26A 2e7fA-1u5uA:
undetectable		 2e7fA-1u5uA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
RE-EXPORTER

(Saccharomyces
cerevisiae) 		PF03378
(CAS_CSE1)
PF03810
(IBN_N)
PF08506
(Cse1) 		5 GLU C 107
ILE C  44
LEU C  41
SER C 110
ARG C 153
 None
 1.17A 2e7fA-1wa5C:
undetectable		 2e7fA-1wa5C:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1

(Saccharomyces
cerevisiae) 		PF00809
(Pterin_bind)
PF01288
(HPPK) 		5 ASP A 591
ASN A 655
ILE A 679
GLY A 803
SER A 805
 None
PMM  A1865 (-2.9A)
PMM  A1865 ( 4.7A)
PMM  A1865 (-3.5A)
None
 1.24A 2e7fA-2bmbA:
19.9		 2e7fA-2bmbA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bmb FOLIC ACID SYNTHESIS
PROTEIN FOL1

(Saccharomyces
cerevisiae) 		PF00809
(Pterin_bind)
PF01288
(HPPK) 		5 ASP A 636
ASN A 655
ILE A 679
GLY A 803
SER A 805
 PMM  A1865 (-3.3A)
PMM  A1865 (-2.9A)
PMM  A1865 ( 4.7A)
PMM  A1865 (-3.5A)
None
 0.59A 2e7fA-2bmbA:
19.9		 2e7fA-2bmbA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g02 NISIN BIOSYNTHESIS
PROTEIN NISC

(Lactococcus
lactis) 		PF05147
(LANC_like) 		5 PHE A  34
ILE A  98
GLY A  93
SER A  86
ILE A  94
 None
 1.23A 2e7fA-2g02A:
undetectable		 2e7fA-2g02A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0v RAC-LIKE GTP-BINDING
PROTEIN ARAC7

(Arabidopsis
thaliana) 		PF00071
(Ras) 		5 GLU A 155
ILE A 148
LEU A  97
GLY A 141
SER A 138
 None
 1.24A 2e7fA-2j0vA:
3.1		 2e7fA-2j0vA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j13 POLYSACCHARIDE
DEACETYLASE

(Bacillus
anthracis) 		PF01522
(Polysacc_deac_1) 		5 GLU A 121
PHE A 110
LEU A  90
GLY A  80
SER A 106
 None
 1.24A 2e7fA-2j13A:
3.2		 2e7fA-2j13A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j4d CRYPTOCHROME DASH

(Arabidopsis
thaliana) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		5 MET A 246
PHE A 248
ASN A 379
GLY A 278
SER A 285
 None
None
None
None
FAD  A1498 (-2.6A)
 1.29A 2e7fA-2j4dA:
undetectable		 2e7fA-2j4dA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2osa N-CHIMAERIN

(Homo sapiens) 		PF00620
(RhoGAP) 		5 GLU A 291
ASP A 335
ASN A 337
GLY A 296
SER A 294
 None
 1.15A 2e7fA-2osaA:
undetectable		 2e7fA-2osaA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyy IONOTROPIC GLUTAMATE
RECEPTOR BACTERIAL
HOMOLOGUE

(Nostoc
punctiforme) 		PF00497
(SBP_bac_3) 		5 PHE A 219
ILE A 198
LEU A  64
GLY A 185
ILE A  85
 None
 1.27A 2e7fA-2pyyA:
undetectable		 2e7fA-2pyyA:
20.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ycj 5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE

(Carboxydothermus
hydrogenoformans) 		PF00809
(Pterin_bind) 		11 GLU A   7
PHE A  13
ASP A  76
ASN A  97
ILE A 121
LEU A 123
GLY A 197
SER A 199
ASN A 200
ARG A 208
ILE A 228
 C2F  A3000 ( 4.1A)
C2F  A3000 (-3.9A)
C2F  A3000 (-3.4A)
C2F  A3000 (-3.0A)
C2F  A3000 ( 4.2A)
None
C2F  A3000 (-3.6A)
GOL  A1270 ( 3.9A)
C2F  A3000 (-3.1A)
C2F  A3000 ( 2.6A)
C2F  A3000 (-4.6A)
 0.26A 2e7fA-2ycjA:
42.9		 2e7fA-2ycjA:
60.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ycj 5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE

(Carboxydothermus
hydrogenoformans) 		PF00809
(Pterin_bind) 		5 MET A  12
ASP A  76
ASN A  97
ILE A 121
LEU A 123
 None
C2F  A3000 (-3.4A)
C2F  A3000 (-3.0A)
C2F  A3000 ( 4.2A)
None
 1.18A 2e7fA-2ycjA:
42.9		 2e7fA-2ycjA:
60.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a18 ALDOXIME DEHYDRATASE

(Rhodococcus
erythropolis) 		PF13816
(Dehydratase_hem) 		5 GLY A 281
SER A 260
ASN A 261
ARG A 345
ILE A 280
 None
 1.28A 2e7fA-3a18A:
undetectable		 2e7fA-3a18A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b05 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE

(Sulfolobus
shibatae) 		PF01070
(FMN_dh) 		5 PHE A 269
ASP A 150
ILE A 147
GLY A  93
ILE A 123
 None
 1.30A 2e7fA-3b05A:
7.7		 2e7fA-3b05A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1f PUTATIVE PREPHENATE
DEHYDROGENASE

(Streptococcus
mutans) 		PF02153
(PDH) 		5 PHE A  79
ILE A  22
LEU A 166
GLY A  15
ILE A   8
 None
 1.11A 2e7fA-3b1fA:
undetectable		 2e7fA-3b1fA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bit FACT COMPLEX SUBUNIT
SPT16

(Saccharomyces
cerevisiae) 		PF00557
(Peptidase_M24)
PF14826
(FACT-Spt16_Nlob) 		5 ILE A 225
LEU A 231
GLY A 190
SER A 188
ILE A 292
 None
 1.14A 2e7fA-3bitA:
undetectable		 2e7fA-3bitA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjb PROBABLE
TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY PROTEIN

(Rhodococcus
jostii) 		PF00440
(TetR_N) 		5 MET A  72
ILE A 189
LEU A 164
GLY A 170
ILE A 172
 None
 1.26A 2e7fA-3bjbA:
undetectable		 2e7fA-3bjbA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bol 5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE

(Thermotoga
maritima) 		PF00809
(Pterin_bind)
PF02574
(S-methyl_trans) 		6 ASN A 411
ILE A 435
LEU A 437
GLY A 505
SER A 507
ASN A 508
 None
 1.00A 2e7fA-3bolA:
26.4		 2e7fA-3bolA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bol 5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE

(Thermotoga
maritima) 		PF00809
(Pterin_bind)
PF02574
(S-methyl_trans) 		8 GLU A 320
ASP A 390
ASN A 411
ILE A 435
LEU A 437
GLY A 505
SER A 507
ILE A 536
 None
 0.66A 2e7fA-3bolA:
26.4		 2e7fA-3bolA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8p ACETYLTRANSFERASE OF
GNAT FAMILY

(Staphylococcus
aureus) 		PF13673
(Acetyltransf_10) 		5 PHE A 146
ASP A  39
ILE A  43
LEU A  16
GLY A  69
 None
 1.24A 2e7fA-3d8pA:
undetectable		 2e7fA-3d8pA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		5 GLU A 140
ILE A  24
LEU A  20
ASN A   5
ARG A 229
 None
 1.26A 2e7fA-3dy5A:
undetectable		 2e7fA-3dy5A:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gm8 GLYCOSIDE HYDROLASE
FAMILY 2, CANDIDATE
BETA-GLYCOSIDASE

(Bacteroides
vulgatus) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		5 GLU A 490
ILE A 462
LEU A 459
GLY A 441
ARG A 159
 GOL  A   1 (-2.5A)
None
None
None
GOL  A   1 (-3.0A)
 1.25A 2e7fA-3gm8A:
6.6		 2e7fA-3gm8A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jz4 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
[NADP+]

(Escherichia
coli) 		PF00171
(Aldedh) 		5 GLU A 235
ILE A 152
LEU A 228
GLY A 237
ILE A 236
 None
NAP  A 482 ( 4.2A)
None
None
NAP  A 482 (-3.6A)
 0.93A 2e7fA-3jz4A:
undetectable		 2e7fA-3jz4A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k13 5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE

(Bacteroides
thetaiotaomicron) 		PF00809
(Pterin_bind) 		5 ASP A 396
GLY A 558
SER A 560
ASN A 561
ARG A 573
 THH  A 642 ( 4.7A)
THH  A 642 (-3.3A)
K  A 644 ( 3.4A)
THH  A 642 ( 3.3A)
THH  A 642 (-3.1A)
 0.91A 2e7fA-3k13A:
29.7		 2e7fA-3k13A:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k13 5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE

(Bacteroides
thetaiotaomicron) 		PF00809
(Pterin_bind) 		8 GLU A 358
ASP A 431
ASN A 452
GLY A 558
SER A 560
ASN A 561
ARG A 573
ILE A 593
 THH  A 642 ( 3.5A)
THH  A 642 (-3.3A)
THH  A 642 (-3.0A)
THH  A 642 (-3.3A)
K  A 644 ( 3.4A)
THH  A 642 ( 3.3A)
THH  A 642 (-3.1A)
THH  A 642 (-4.2A)
 0.28A 2e7fA-3k13A:
29.7		 2e7fA-3k13A:
26.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kd8 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Thermoplasma
acidophilum) 		PF01676
(Metalloenzyme)
PF10143
(PhosphMutase) 		5 ILE A 390
GLY A  44
SER A 375
ASN A  43
ILE A 355
 None
 1.30A 2e7fA-3kd8A:
undetectable		 2e7fA-3kd8A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lun ULILYSIN

(Methanosarcina
acetivorans) 		PF05572
(Peptidase_M43) 		5 GLU A 229
ILE A 121
LEU A 313
GLY A 231
ILE A 230
 ZN  A 999 ( 3.8A)
None
None
None
None
 1.19A 2e7fA-3lunA:
undetectable		 2e7fA-3lunA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8l CAPSID PROTEIN

(Feline
calicivirus) 		PF00915
(Calici_coat) 		5 PHE A 641
LEU A 529
GLY A 351
ASN A 584
ILE A 350
 None
 1.32A 2e7fA-3m8lA:
undetectable		 2e7fA-3m8lA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozy PUTATIVE MANDELATE
RACEMASE

(Bordetella
bronchiseptica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ASP A 116
ILE A 310
LEU A  37
GLY A 109
ILE A 112
 None
 1.25A 2e7fA-3ozyA:
10.0		 2e7fA-3ozyA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rh9 SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE
(NAD(P)(+))

(Marinobacter
hydrocarbonoclasticus) 		PF00171
(Aldedh) 		5 MET A 188
PHE A 192
LEU A 240
GLY A 150
SER A 176
 None
 1.28A 2e7fA-3rh9A:
undetectable		 2e7fA-3rh9A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sn0 PUTATIVE
L-ALANINE-DL-GLUTAMA
TE EPIMERASE

(Paraburkholderia
xenovorans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLU A  34
PHE A 354
ASN A 317
ARG A 346
ILE A 292
 None
 1.28A 2e7fA-3sn0A:
11.0		 2e7fA-3sn0A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufc PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF01881
(Cas_Cas6) 		5 GLU X  95
ILE X  28
LEU X  43
GLY X  93
ILE X  94
 None
 1.25A 2e7fA-3ufcX:
undetectable		 2e7fA-3ufcX:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8b PUTATIVE
DEHYDROGENASE,
POSSIBLY
3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		5 ILE A 234
LEU A  25
GLY A  18
SER A  15
ILE A  17
 None
 1.27A 2e7fA-3v8bA:
undetectable		 2e7fA-3v8bA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va6 TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE

(Bacteroides
thetaiotaomicron) 		PF07494
(Reg_prop)
PF07495
(Y_Y_Y) 		5 ILE A 319
LEU A 280
GLY A 322
SER A  52
ARG A  91
 None
 1.28A 2e7fA-3va6A:
undetectable		 2e7fA-3va6A:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w08 ALDOXIME DEHYDRATASE

(Pseudomonas
chlororaphis) 		PF13816
(Dehydratase_hem) 		5 GLY A 281
SER A 260
ASN A 261
ARG A 345
ILE A 280
 None
 1.30A 2e7fA-3w08A:
undetectable		 2e7fA-3w08A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4afr METACASPASE

(Trypanosoma
brucei) 		PF00656
(Peptidase_C14) 		5 MET A 254
ILE A  80
GLY A 159
SER A 215
ILE A 176
 None
 1.23A 2e7fA-4afrA:
undetectable		 2e7fA-4afrA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bmr RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA

(Bacillus cereus) 		PF00268
(Ribonuc_red_sm) 		5 PHE A 256
ILE A 103
LEU A 107
GLY A 185
ILE A 188
 None
 1.22A 2e7fA-4bmrA:
undetectable		 2e7fA-4bmrA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c23 L-FUCULOSE KINASE
FUCK

(Streptococcus
pneumoniae) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 ILE A  56
LEU A   9
GLY A  73
ASN A 432
ILE A  72
 None
 1.23A 2e7fA-4c23A:
undetectable		 2e7fA-4c23A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccz METHIONINE SYNTHASE

(Homo sapiens) 		PF00809
(Pterin_bind)
PF02574
(S-methyl_trans) 		5 ASP A 414
GLY A 576
SER A 578
ASN A 579
ARG A 591
 None
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
THG  A1652 (-3.1A)
THG  A1652 (-3.0A)
 0.99A 2e7fA-4cczA:
30.0		 2e7fA-4cczA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccz METHIONINE SYNTHASE

(Homo sapiens) 		PF00809
(Pterin_bind)
PF02574
(S-methyl_trans) 		8 GLU A 376
ASP A 449
ASN A 470
GLY A 576
SER A 578
ASN A 579
ARG A 591
ILE A 611
 THG  A1652 (-3.5A)
THG  A1652 (-3.4A)
THG  A1652 (-3.2A)
THG  A1652 (-3.6A)
THG  A1652 (-4.2A)
THG  A1652 (-3.1A)
THG  A1652 (-3.0A)
THG  A1652 (-4.2A)
 0.41A 2e7fA-4cczA:
30.0		 2e7fA-4cczA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cdb LISTERIOLYSIN O

(Listeria
monocytogenes) 		PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C) 		5 PHE A 464
ILE A 477
SER A 454
ASN A 456
ILE A 468
 None
 1.10A 2e7fA-4cdbA:
undetectable		 2e7fA-4cdbA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dns FAD-LINKED
OXIDOREDUCTASE BG60

(Cynodon
dactylon) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 PHE A 166
ILE A 357
LEU A 361
SER A 342
ILE A 398
 FAD  A 501 (-4.1A)
None
None
None
None
 1.22A 2e7fA-4dnsA:
undetectable		 2e7fA-4dnsA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4drt DE NOVO DESIGNED
SERINE HYDROLASE,
OR89

(synthetic
construct) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		5 ILE A 237
LEU A 257
GLY A 212
ASN A 200
ILE A 213
 None
 1.17A 2e7fA-4drtA:
undetectable		 2e7fA-4drtA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dvj PUTATIVE
ZINC-DEPENDENT
ALCOHOL
DEHYDROGENASE
PROTEIN

(Rhizobium etli) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		5 ASP A 107
ILE A  55
GLY A 133
SER A 314
ASN A 311
 None
 1.09A 2e7fA-4dvjA:
3.2		 2e7fA-4dvjA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e6e CELL DIVISION
PROTEIN FTSZ

(Thermobifida
fusca) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 GLU A 136
PHE A 180
ILE A 148
LEU A 151
GLY A 103
 None
 1.28A 2e7fA-4e6eA:
2.6		 2e7fA-4e6eA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f52 GLOMULIN

(Homo sapiens) 		PF08568
(Kinetochor_Ybp2) 		5 GLU E  38
ILE E  89
LEU E  93
GLY E  33
ILE E  37
 None
 1.05A 2e7fA-4f52E:
undetectable		 2e7fA-4f52E:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f92 U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		5 GLU B 890
PHE B 416
ILE B 617
LEU B 665
ILE B 889
 None
 1.22A 2e7fA-4f92B:
undetectable		 2e7fA-4f92B:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gba DCN1-LIKE PROTEIN 3

(Homo sapiens) 		PF03556
(Cullin_binding) 		5 PHE A 270
ASN A 231
GLY A 237
SER A 239
ILE A 235
 None
 1.09A 2e7fA-4gbaA:
undetectable		 2e7fA-4gbaA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gnk 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3

(Homo sapiens) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		5 PHE B 805
LEU B 308
GLY B 688
ASN B 830
ILE B 810
 None
 1.31A 2e7fA-4gnkB:
6.6		 2e7fA-4gnkB:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l0o CYSTATHIONINE
GAMMA-SYNTHASE

(Helicobacter
pylori) 		no annotation 5 ASP H 170
ILE H 168
GLY H  77
SER H  73
ILE H  78
 PLP  H 401 (-3.2A)
None
None
PLP  H 401 (-3.5A)
None
 1.05A 2e7fA-4l0oH:
undetectable		 2e7fA-4l0oH:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m75 U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM1
U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM4

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF01423
(LSM)
PF01423
(LSM) 		5 GLU A 107
MET G  36
ASP A  72
ILE A  46
LEU A  68
 None
 1.21A 2e7fA-4m75A:
undetectable		 2e7fA-4m75A:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9d ADENYLOSUCCINATE
SYNTHETASE

(Bacillus
anthracis) 		PF00709
(Adenylsucc_synt) 		5 GLU A 295
ILE A 337
LEU A 340
SER A 270
ILE A 289
 None
 1.13A 2e7fA-4m9dA:
undetectable		 2e7fA-4m9dA:
18.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o1e DIHYDROPTEROATE
SYNTHASE DHPS

(Desulfitobacterium
hafniense) 		PF00809
(Pterin_bind) 		6 ASN A  97
ILE A 121
LEU A 123
GLY A 196
ASN A 199
ARG A 207
 C2F  A3000 (-3.0A)
C2F  A3000 ( 4.1A)
None
C2F  A3000 (-3.5A)
C2F  A3000 ( 4.3A)
None
 0.82A 2e7fA-4o1eA:
33.9		 2e7fA-4o1eA:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o1e DIHYDROPTEROATE
SYNTHASE DHPS

(Desulfitobacterium
hafniense) 		PF00809
(Pterin_bind) 		7 ASP A  76
ASN A  97
ILE A 121
GLY A 196
SER A 198
ARG A 207
ILE A 227
 C2F  A3000 (-3.6A)
C2F  A3000 (-3.0A)
C2F  A3000 ( 4.1A)
C2F  A3000 (-3.5A)
C2F  A3000 ( 3.8A)
None
C2F  A3000 (-4.3A)
 1.15A 2e7fA-4o1eA:
33.9		 2e7fA-4o1eA:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o1e DIHYDROPTEROATE
SYNTHASE DHPS

(Desulfitobacterium
hafniense) 		PF00809
(Pterin_bind) 		7 ASP A  76
ASN A  97
ILE A 121
LEU A 123
GLY A 196
ARG A 207
ILE A 227
 C2F  A3000 (-3.6A)
C2F  A3000 (-3.0A)
C2F  A3000 ( 4.1A)
None
C2F  A3000 (-3.5A)
None
C2F  A3000 (-4.3A)
 0.85A 2e7fA-4o1eA:
33.9		 2e7fA-4o1eA:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o1e DIHYDROPTEROATE
SYNTHASE DHPS

(Desulfitobacterium
hafniense) 		PF00809
(Pterin_bind) 		7 GLU A   7
ASP A  76
ASN A  97
ILE A 121
LEU A 123
GLY A 196
ILE A 227
 C2F  A3000 (-3.6A)
C2F  A3000 (-3.6A)
C2F  A3000 (-3.0A)
C2F  A3000 ( 4.1A)
None
C2F  A3000 (-3.5A)
C2F  A3000 (-4.3A)
 0.54A 2e7fA-4o1eA:
33.9		 2e7fA-4o1eA:
32.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oua LATENT FORM OF PPO4
TYROSINASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		5 PHE B 257
ILE B 522
GLY B 475
ASN B 245
ILE B 451
 None
 1.28A 2e7fA-4ouaB:
undetectable		 2e7fA-4ouaB:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pe5 GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 MET B 789
PHE B 784
ILE B 408
LEU B 478
ILE B 764
 None
 1.18A 2e7fA-4pe5B:
undetectable		 2e7fA-4pe5B:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3

(Homo sapiens) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		5 PHE B 805
LEU B 313
GLY B 688
ASN B 830
ILE B 810
 None
 1.29A 2e7fA-4qj4B:
5.8		 2e7fA-4qj4B:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3z ARGININE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		5 PHE B 416
ASN B 236
LEU B 319
GLY B 239
ASN B 202
 None
 1.22A 2e7fA-4r3zB:
undetectable		 2e7fA-4r3zB:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s2t PROTEIN APP-1

(Caenorhabditis
elegans) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		5 ILE P 502
LEU P 513
SER P 558
ARG P 588
ILE P 521
 None
None
SO4  P 704 (-4.9A)
SO4  P 704 (-4.0A)
None
 1.30A 2e7fA-4s2tP:
undetectable		 2e7fA-4s2tP:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uw9 BETA-PHOSPHOGLUCOMUT
ASE

(Pyrococcus sp.
ST04) 		PF13419
(HAD_2) 		5 GLU A 100
PHE A  14
LEU A 221
GLY A 214
SER A 212
 None
 1.29A 2e7fA-4uw9A:
undetectable		 2e7fA-4uw9A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xqk LLABIII

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII)
PF13156
(Mrr_cat_2) 		5 GLU A 958
PHE A 936
ILE A 845
ARG A1003
ILE A 955
 None
 1.30A 2e7fA-4xqkA:
undetectable		 2e7fA-4xqkA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xyb FORMATE
DEHYDROGENASE

(Granulicella
mallensis) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 GLU A 175
ASP A 182
ILE A 180
GLY A 177
ILE A 172
 None
 1.25A 2e7fA-4xybA:
undetectable		 2e7fA-4xybA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yo1 DEGQ

(Legionella
pneumophila) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 GLU A 200
ASP A 137
ILE A 179
LEU A 165
ILE A 202
 CD  A 401 (-2.1A)
None
None
None
None
 1.19A 2e7fA-4yo1A:
undetectable		 2e7fA-4yo1A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8r METHYL-COENZYME M
REDUCTASE II SUBUNIT
GAMMA

(Methanothermobacter
marburgensis) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		5 ILE B 422
LEU B 113
GLY B 416
SER B 412
ILE B 203
 None
 1.13A 2e7fA-5a8rB:
undetectable		 2e7fA-5a8rB:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dqp EDTA MONOOXYGENASE

(EDTA-degrading
bacterium BNC1) 		PF00296
(Bac_luciferase) 		5 ILE A  82
LEU A  55
GLY A  90
ARG A   5
ILE A  89
 None
 1.18A 2e7fA-5dqpA:
2.1		 2e7fA-5dqpA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dqp EDTA MONOOXYGENASE

(EDTA-degrading
bacterium BNC1) 		PF00296
(Bac_luciferase) 		5 PHE A 409
ILE A  82
LEU A  55
GLY A  90
ILE A  89
 None
 1.24A 2e7fA-5dqpA:
2.1		 2e7fA-5dqpA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epg ALDEHYDE OXIDASE

(Homo sapiens) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 ASN A  72
GLY A 346
ASN A 436
ARG A 429
ILE A 349
 FES  A3002 ( 3.8A)
None
None
FAD  A3004 (-4.1A)
FAD  A3004 ( 4.3A)
 1.20A 2e7fA-5epgA:
undetectable		 2e7fA-5epgA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g06 EXOSOME COMPLEX
COMPONENT SKI6

(Saccharomyces
cerevisiae) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 ASP B 173
GLY B 160
SER B 159
ASN B 141
ILE B 161
 None
 1.13A 2e7fA-5g06B:
undetectable		 2e7fA-5g06B:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g2v N-ACETYLGLUCOSAMINE-
6-SULFATASE

(Bacteroides
thetaiotaomicron) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		5 ILE A 344
LEU A 333
GLY A 327
ARG A 207
ILE A 326
 None
 0.93A 2e7fA-5g2vA:
undetectable		 2e7fA-5g2vA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gnd PUTATIVE SERINE
PROTEASE HHOA

(Synechocystis
sp. PCC 6803) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 GLU A 247
ILE A 226
LEU A 209
ASN A 181
ILE A 249
 None
 0.95A 2e7fA-5gndA:
undetectable		 2e7fA-5gndA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1

(Saccharomyces
cerevisiae) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		5 GLU A1411
ILE A 138
LEU A 113
GLY A 223
SER A1415
 None
 1.27A 2e7fA-5ip9A:
undetectable		 2e7fA-5ip9A:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxk ASP/GLU-SPECIFIC
DIPEPTIDYL-PEPTIDASE

(Porphyromonas
endodontalis) 		PF10459
(Peptidase_S46) 		5 GLU A 712
ILE A 693
LEU A 666
SER A  75
ILE A 713
 None
 1.28A 2e7fA-5jxkA:
undetectable		 2e7fA-5jxkA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ksd ATPASE 2, PLASMA
MEMBRANE-TYPE

(Arabidopsis
thaliana) 		PF00122
(E1-E2_ATPase)
PF00690
(Cation_ATPase_N)
PF00702
(Hydrolase) 		5 GLU A 319
ILE A 628
LEU A 620
GLY A 602
ILE A 601
 None
 1.07A 2e7fA-5ksdA:
undetectable		 2e7fA-5ksdA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m59 PRE-MRNA SPLICING
HELICASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		5 GLU A 940
PHE A 465
ILE A 665
LEU A 713
ILE A 939
 None
 1.15A 2e7fA-5m59A:
undetectable		 2e7fA-5m59A:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5p PRE-MRNA-SPLICING
HELICASE BRR2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		5 GLU A 909
PHE A 434
ILE A 636
LEU A 684
ILE A 908
 None
 1.28A 2e7fA-5m5pA:
undetectable		 2e7fA-5m5pA:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5me3 SISTER CHROMATID
COHESION PROTEIN 2

(Eremothecium
gossypii) 		PF12765
(Cohesin_HEAT)
PF12830
(Nipped-B_C) 		5 MET A 719
LEU A 535
GLY A 560
SER A 561
ILE A 563
 None
 1.26A 2e7fA-5me3A:
undetectable		 2e7fA-5me3A:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5suo EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF12010
(DUF3502) 		5 ASN A 161
ILE A 305
LEU A 295
GLY A 286
ASN A 155
 None
 1.25A 2e7fA-5suoA:
undetectable		 2e7fA-5suoA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE

(Thermus
thermophilus) 		no annotation 9 GLU A 373
ASP A 443
ASN A 464
LEU A 492
GLY A 570
SER A 572
ASN A 573
ARG A 583
ILE A 603
 C2F  A3001 (-3.7A)
C2F  A3001 (-2.5A)
C2F  A3001 (-2.2A)
None
C2F  A3001 (-3.5A)
C2F  A3001 ( 4.5A)
C2F  A3001 (-2.6A)
C2F  A3001 (-3.0A)
C2F  A3001 (-3.5A)
 0.28A 2e7fA-5vopA:
30.7		 2e7fA-5vopA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xni MCYF

(Microcystis
aeruginosa) 		no annotation 5 PHE A 137
ILE A  83
LEU A   8
GLY A  86
ILE A  85
 None
 1.19A 2e7fA-5xniA:
undetectable		 2e7fA-5xniA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4g AMBP3

(Fischerella
ambigua) 		no annotation 5 GLU A 207
PHE A 288
ILE A 185
LEU A 186
ILE A 208
 None
 1.17A 2e7fA-5y4gA:
undetectable		 2e7fA-5y4gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5i RETINAL
DEHYDROGENASE 2

(Homo sapiens) 		no annotation 5 MET A 123
ILE A 197
LEU A 109
GLY A 223
ILE A 238
 None
 1.26A 2e7fA-6b5iA:
undetectable		 2e7fA-6b5iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c1d UNCONVENTIONAL
MYOSIN-IB

(Rattus
norvegicus) 		no annotation 5 GLU P 392
PHE P 394
LEU P 621
GLY P 108
SER P 110
 None
 1.10A 2e7fA-6c1dP:
2.8		 2e7fA-6c1dP:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6chs PUTATIVE CELL
DIVISION CONTROL
PROTEIN

(Chaetomium
thermophilum) 		no annotation 5 MET H 404
ILE H 222
LEU H 269
GLY H 424
ILE H 396
 None
None
AGS  H 901 (-4.4A)
AGS  H 901 (-3.5A)
AGS  H 901 ( 4.2A)
 1.26A 2e7fA-6chsH:
2.3		 2e7fA-6chsH:
undetectable