SIMILAR PATTERNS OF AMINO ACIDS FOR 2E1Q_C_SALC4006_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj2 ADENYLOSUCCINATE
SYNTHETASE

(Arabidopsis
thaliana) 		PF00709
(Adenylsucc_synt) 		4 PHE A  45
VAL A  24
LEU A  37
ALA A  42
 None
 1.01A 2e1qC-1dj2A:
0.0		 2e1qC-1dj2A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj3 ADENYLOSUCCINATE
SYNTHETASE

(Triticum
aestivum) 		PF00709
(Adenylsucc_synt) 		4 PHE A  44
VAL A  23
LEU A  36
ALA A  41
 None
 1.00A 2e1qC-1dj3A:
undetectable		 2e1qC-1dj3A:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e33 ARYLSULFATASE A

(Homo sapiens) 		PF00884
(Sulfatase)
PF14707
(Sulfatase_C) 		4 PHE P 141
THR P 106
VAL P 107
LEU P 111
 None
 1.05A 2e1qC-1e33P:
undetectable		 2e1qC-1e33P:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ih5 AQUAPORIN-1

(Homo sapiens) 		PF00230
(MIP) 		4 PHE A 197
THR A 109
VAL A 107
ALA A 194
 None
 1.04A 2e1qC-1ih5A:
0.0		 2e1qC-1ih5A:
13.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		6 ARG A 880
PHE A 914
THR A1010
VAL A1011
LEU A1014
ALA A1079
 TEI  A3006 (-3.5A)
TEI  A3006 (-3.6A)
TEI  A3006 (-2.8A)
TEI  A3006 (-4.8A)
None
TEI  A3006 ( 3.8A)
 0.26A 2e1qC-1n5xA:
45.7		 2e1qC-1n5xA:
89.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oa1 HYDROXYLAMINE
REDUCTASE

(Desulfovibrio
vulgaris) 		PF03063
(Prismane) 		4 ARG A 171
VAL A  62
LEU A  66
ALA A 162
 None
 0.82A 2e1qC-1oa1A:
undetectable		 2e1qC-1oa1A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pby QUINOHEMOPROTEIN
AMINE DEHYDROGENASE
60 KDA SUBUNIT

(Paracoccus
denitrificans) 		PF09098
(Dehyd-heme_bind)
PF09099
(Qn_am_d_aIII)
PF09100
(Qn_am_d_aIV)
PF14930
(Qn_am_d_aII) 		4 THR A 411
VAL A 459
LEU A 476
ALA A 427
 None
 0.98A 2e1qC-1pbyA:
undetectable		 2e1qC-1pbyA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qwj CYTIDINE
MONOPHOSPHO-N-ACETYL
NEURAMINIC ACID
SYNTHETASE

(Mus musculus) 		PF02348
(CTP_transf_3) 		4 PHE A  83
VAL A  73
LEU A 147
ALA A  80
 None
 1.00A 2e1qC-1qwjA:
0.0		 2e1qC-1qwjA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ug3 EUKARYOTIC PROTEIN
SYNTHESIS INITIATION
FACTOR 4G

(Homo sapiens) 		PF02020
(W2)
PF02847
(MA3) 		4 PHE A1561
VAL A1555
LEU A1516
ALA A1560
 None
 0.88A 2e1qC-1ug3A:
0.0		 2e1qC-1ug3A:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1us4 PUTATIVE GLUR0
LIGAND BINDING CORE

(Thermus
thermophilus) 		PF16868
(NMT1_3) 		4 ARG A 118
VAL A 134
LEU A 129
ALA A 121
 None
 1.05A 2e1qC-1us4A:
undetectable		 2e1qC-1us4A:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6h DIVALENT CATION
TOLERANCE PROTEIN
CUTA1

(Thermus
thermophilus) 		PF03091
(CutA1) 		4 PHE A  64
VAL A  57
LEU A  22
ALA A  63
 None
 1.00A 2e1qC-1v6hA:
undetectable		 2e1qC-1v6hA:
6.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9p DNA LIGASE

(Thermus
filiformis) 		PF01653
(DNA_ligase_aden)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		4 ARG A 209
THR A 138
VAL A 124
ALA A 205
 None
 1.06A 2e1qC-1v9pA:
undetectable		 2e1qC-1v9pA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w45 ANNEXIN A8

(Homo sapiens) 		PF00191
(Annexin) 		4 ARG A 167
THR A 251
VAL A 248
ALA A 121
 None
 1.04A 2e1qC-1w45A:
undetectable		 2e1qC-1w45A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1

(Thermus
thermophilus) 		PF02347
(GDC-P) 		4 PHE A 378
VAL A 366
LEU A 382
ALA A 379
 None
 0.98A 2e1qC-1wytA:
undetectable		 2e1qC-1wytA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcc GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE

(Agrobacterium
fabrum) 		PF03009
(GDPD) 		4 PHE A  19
VAL A  47
LEU A  35
ALA A  22
 None
 1.00A 2e1qC-1zccA:
undetectable		 2e1qC-1zccA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1g ACID PHOSPHATASE

(Francisella
tularensis) 		PF04185
(Phosphoesterase) 		4 ARG A  94
THR A 150
VAL A 151
ALA A  57
 None
 0.97A 2e1qC-2d1gA:
undetectable		 2e1qC-2d1gA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwg 52 KDA RO PROTEIN

(Homo sapiens) 		PF00622
(SPRY)
PF13765
(PRY) 		5 ARG B 160
THR B  12
VAL B  48
LEU B   8
ALA B  51
 None
 1.47A 2e1qC-2iwgB:
undetectable		 2e1qC-2iwgB:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n57 ACYL CARRIER PROTEIN

(Brucella
melitensis) 		PF00550
(PP-binding) 		4 THR A  40
VAL A  41
LEU A  38
ALA A  35
 None
 1.01A 2e1qC-2n57A:
undetectable		 2e1qC-2n57A:
4.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2or0 HYDROXYLASE

(Rhodococcus
jostii) 		PF08028
(Acyl-CoA_dh_2) 		4 PHE A  90
VAL A  83
LEU A  45
ALA A  89
 None
 1.06A 2e1qC-2or0A:
undetectable		 2e1qC-2or0A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p8t HYPOTHETICAL PROTEIN
PH0730

(Pyrococcus
horikoshii) 		PF14544
(DUF4443) 		4 PHE A 120
THR A  16
VAL A  17
LEU A  21
 None
 0.97A 2e1qC-2p8tA:
2.3		 2e1qC-2p8tA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p8u HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
CYTOPLASMIC

(Homo sapiens) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		4 THR A 389
VAL A 388
LEU A 187
ALA A 397
 None
 0.97A 2e1qC-2p8uA:
undetectable		 2e1qC-2p8uA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6u NIKD PROTEIN

(Streptomyces
tendae) 		PF01266
(DAO) 		4 PHE A 132
THR A 310
VAL A 311
LEU A 304
 None
 1.04A 2e1qC-2q6uA:
undetectable		 2e1qC-2q6uA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qnr SEPTIN-2

(Homo sapiens) 		PF00735
(Septin) 		4 ARG A 145
PHE A 126
THR A 291
LEU A 294
 None
 1.01A 2e1qC-2qnrA:
undetectable		 2e1qC-2qnrA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qq4 IRON-SULFUR CLUSTER
BIOSYNTHESIS PROTEIN
ISCU

(Thermus
thermophilus) 		PF01592
(NifU_N) 		4 PHE A  59
THR A  75
LEU A  73
ALA A 129
 None
 0.97A 2e1qC-2qq4A:
4.8		 2e1qC-2qq4A:
7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgj FLAVIN-CONTAINING
MONOOXYGENASE

(Pseudomonas
aeruginosa) 		PF01494
(FAD_binding_3) 		4 ARG A 282
THR A 194
VAL A 193
LEU A 232
 None
 1.01A 2e1qC-2rgjA:
undetectable		 2e1qC-2rgjA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w55 XANTHINE
DEHYDROGENASE

(Rhodobacter
capsulatus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 ARG B 310
PHE B 344
THR B 460
LEU B 464
ALA B 529
 HPA  B1780 (-3.4A)
HPA  B1780 (-3.4A)
HPA  B1780 (-3.6A)
None
HPA  B1780 ( 3.2A)
 0.41A 2e1qC-2w55B:
56.8		 2e1qC-2w55B:
26.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wvq SMALL S PROTEIN

(Podospora
anserina) 		PF14479
(HeLo) 		4 PHE A  91
VAL A 160
LEU A 156
ALA A  94
 None
 0.93A 2e1qC-2wvqA:
undetectable		 2e1qC-2wvqA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1a 5'-NUCLEOTIDASE

(Thermus
thermophilus) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		4 ARG A 226
VAL A 260
LEU A 270
ALA A 225
 None
 1.00A 2e1qC-2z1aA:
undetectable		 2e1qC-2z1aA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5r BENZALACETONE
SYNTHASE

(Rheum palmatum) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 ARG A 178
VAL A  12
LEU A 232
ALA A 171
 None
 1.01A 2e1qC-3a5rA:
undetectable		 2e1qC-3a5rA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aiz DNA POLYMERASE
SLIDING CLAMP B

(Sulfurisphaera
tokodaii) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 ARG A 103
THR A 101
VAL A 100
LEU A  91
 SO4  A 249 (-3.2A)
SO4  A 249 ( 4.1A)
None
None
 1.05A 2e1qC-3aizA:
undetectable		 2e1qC-3aizA:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b0z FLAGELLAR
BIOSYNTHETIC PROTEIN
FLHB

(Salmonella
enterica) 		PF01312
(Bac_export_2) 		4 ARG B 302
THR A 268
VAL A 267
ALA B 298
 None
 1.05A 2e1qC-3b0zB:
undetectable		 2e1qC-3b0zB:
6.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8i PA4872 OXALOACETATE
DECARBOXYLASE

(Pseudomonas
aeruginosa) 		PF13714
(PEP_mutase) 		4 ARG A 108
VAL A 103
LEU A 114
ALA A 109
 None
 1.06A 2e1qC-3b8iA:
undetectable		 2e1qC-3b8iA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3buj CALO2

(Micromonospora
echinospora) 		PF00067
(p450) 		4 PHE A  81
THR A  63
VAL A  66
LEU A  71
 None
 1.00A 2e1qC-3bujA:
0.8		 2e1qC-3bujA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3chl ALPHA-14 GIARDIN

(Giardia
intestinalis) 		PF00191
(Annexin) 		4 PHE A 249
VAL A 105
LEU A 109
ALA A 246
 None
 0.97A 2e1qC-3chlA:
undetectable		 2e1qC-3chlA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddm PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Bordetella
bronchiseptica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ARG A  71
THR A  75
VAL A  76
LEU A  77
 None
 0.94A 2e1qC-3ddmA:
2.1		 2e1qC-3ddmA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1s EXODEOXYRIBONUCLEASE
V, SUBUNIT RECD

(Deinococcus
radiodurans) 		PF13538
(UvrD_C_2)
PF13604
(AAA_30)
PF14490
(HHH_4) 		4 PHE A 603
THR A 407
VAL A 408
LEU A 412
 None
 1.03A 2e1qC-3e1sA:
undetectable		 2e1qC-3e1sA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 THR A 379
VAL A 378
LEU A 349
ALA A 386
 None
FAB  A 701 ( 4.7A)
None
None
 0.96A 2e1qC-3e9yA:
undetectable		 2e1qC-3e9yA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		4 ARG A 140
THR A 138
VAL A 137
LEU A 150
 None
 1.02A 2e1qC-3ecqA:
undetectable		 2e1qC-3ecqA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ffr PHOSPHOSERINE
AMINOTRANSFERASE
SERC

(Cytophaga
hutchinsonii) 		PF00266
(Aminotran_5) 		4 THR A  17
VAL A  18
LEU A  14
ALA A 343
 None
 1.01A 2e1qC-3ffrA:
undetectable		 2e1qC-3ffrA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fw8 RETICULINE OXIDASE

(Eschscholzia
californica) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 PHE A 313
VAL A 281
LEU A 389
ALA A 270
 None
 1.04A 2e1qC-3fw8A:
2.4		 2e1qC-3fw8A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gfh ETHANOLAMINE
UTILIZATION PROTEIN
EUTL

(Escherichia
coli) 		PF00936
(BMC) 		4 PHE A 189
VAL A 152
LEU A 125
ALA A 149
 None
None
None
HG  A 800 (-2.4A)
 0.88A 2e1qC-3gfhA:
undetectable		 2e1qC-3gfhA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gq9 PRENECK APPENDAGE
PROTEIN

(Bacillus virus
phi29) 		PF11962
(Peptidase_G2)
PF12708
(Pectate_lyase_3) 		4 ARG A 537
THR A 534
VAL A 535
LEU A 514
 None
 1.04A 2e1qC-3gq9A:
undetectable		 2e1qC-3gq9A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8o IMMUNOGLOBULIN A1
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ARG H 170
THR H 168
VAL H 167
LEU H 191
 None
 0.99A 2e1qC-3m8oH:
undetectable		 2e1qC-3m8oH:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mem PUTATIVE SIGNAL
TRANSDUCTION PROTEIN

(Marinobacter
hydrocarbonoclasticus) 		PF04073
(tRNA_edit)
PF08668
(HDOD) 		4 THR A 374
VAL A 373
LEU A 313
ALA A 360
 None
 0.95A 2e1qC-3memA:
undetectable		 2e1qC-3memA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvc GLOBIN PROTEIN 6

(Caenorhabditis
elegans) 		PF00042
(Globin) 		4 PHE A 306
THR A 339
VAL A 338
LEU A 279
 HEM  A 500 ( 4.1A)
None
None
None
 0.93A 2e1qC-3mvcA:
undetectable		 2e1qC-3mvcA:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pbl D(3) DOPAMINE
RECEPTOR, LYSOZYME
CHIMERA

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 PHE A1153
VAL A1087
LEU A1118
ALA A1129
 None
 0.94A 2e1qC-3pblA:
undetectable		 2e1qC-3pblA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 PHE A1153
VAL A1087
LEU A1118
ALA A1129
 None
 0.99A 2e1qC-3pdsA:
undetectable		 2e1qC-3pdsA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3puk SYNTAXIN-BINDING
PROTEIN 3

(Mus musculus) 		PF00995
(Sec1) 		4 ARG A 240
THR A 247
VAL A 248
LEU A 249
 None
 1.01A 2e1qC-3pukA:
undetectable		 2e1qC-3pukA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae) 		PF08659
(KR) 		4 THR A 189
VAL A 190
LEU A 191
ALA A  53
 None
 0.86A 2e1qC-3qp9A:
undetectable		 2e1qC-3qp9A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rg2 ENTEROBACTIN
SYNTHASE COMPONENT E
(ENTE),
2,3-DIHYDRO-2,3-DIHY
DROXYBENZOATE
SYNTHETASE,
ISOCHROISMATASE
(ENTB)

(Escherichia
coli) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF13193
(AMP-binding_C) 		4 ARG A  66
VAL A  98
LEU A  93
ALA A  62
 None
 0.86A 2e1qC-3rg2A:
undetectable		 2e1qC-3rg2A:
18.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		6 ARG C 880
PHE C 914
THR C1010
VAL C1011
LEU C1014
ALA C1079
 None
RMO  C1317 (-3.6A)
None
None
None
RMO  C1317 ( 3.6A)
 0.34A 2e1qC-3sr6C:
64.8		 2e1qC-3sr6C:
61.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3suc PRENECK APPENDAGE
PROTEIN

(Bacillus virus
phi29) 		PF11962
(Peptidase_G2)
PF12708
(Pectate_lyase_3) 		4 ARG A 537
THR A 534
VAL A 535
LEU A 514
 None
 0.95A 2e1qC-3sucA:
undetectable		 2e1qC-3sucA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ups IOJAP-LIKE PROTEIN

(Zymomonas
mobilis) 		PF02410
(RsfS) 		4 THR A  24
VAL A  23
LEU A  68
ALA A  32
 None
 1.04A 2e1qC-3upsA:
undetectable		 2e1qC-3upsA:
7.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v2y SPHINGOSINE
1-PHOSPHATE RECEPTOR
1, LYSOZYME CHIMERA
(E.C.3.2.1.17)

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 PHE A1153
VAL A1087
LEU A1118
ALA A1129
 None
 1.01A 2e1qC-3v2yA:
undetectable		 2e1qC-3v2yA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4z ANTIVIRAL HELICASE
SKI2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		4 THR A 793
VAL A 792
LEU A 752
ALA A 761
 None
 0.96A 2e1qC-4a4zA:
undetectable		 2e1qC-4a4zA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bin N-ACETYLMURAMOYL-L-A
LANINE AMIDASE AMIC

(Escherichia
coli) 		PF01520
(Amidase_3)
PF11741
(AMIN) 		4 ARG A  40
THR A  51
VAL A 139
LEU A 128
 None
 1.06A 2e1qC-4binA:
undetectable		 2e1qC-4binA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4by6 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1
GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 2

(Saccharomyces
cerevisiae) 		PF04054
(Not1)
PF04153
(NOT2_3_5) 		4 PHE B  56
THR A1755
VAL A1754
LEU A1757
 None
 0.90A 2e1qC-4by6B:
undetectable		 2e1qC-4by6B:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d3y LEGUMAIN

(Cricetulus
griseus) 		PF01650
(Peptidase_C13) 		4 PHE A 391
VAL A 412
LEU A 416
ALA A 387
 None
 0.82A 2e1qC-4d3yA:
undetectable		 2e1qC-4d3yA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ea1 DEHYDROSQUALENE
SYNTHASE

(Staphylococcus
aureus) 		PF00494
(SQS_PSY) 		4 ARG A 158
VAL A 140
LEU A 141
ALA A 157
 None
 0.99A 2e1qC-4ea1A:
undetectable		 2e1qC-4ea1A:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i7l LYSOZYME

(Escherichia
virus T4) 		PF00959
(Phage_lysozyme) 		4 PHE A 153
VAL A  87
LEU A 118
ALA A 129
 IPH  A 202 (-4.4A)
IPH  A 202 ( 4.4A)
None
None
 1.02A 2e1qC-4i7lA:
undetectable		 2e1qC-4i7lA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jg9 LIPOPROTEIN

(Bacillus
anthracis) 		PF16167
(DUF4871) 		4 THR A 115
VAL A 114
LEU A  47
ALA A  41
 None
 0.93A 2e1qC-4jg9A:
undetectable		 2e1qC-4jg9A:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9d RIK1-ASSOCIATED
FACTOR 1

(Schizosaccharomyces
pombe) 		no annotation 4 THR B 504
VAL B 514
LEU B 527
ALA B 552
 None
 1.05A 2e1qC-4o9dB:
undetectable		 2e1qC-4o9dB:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ons CATENIN ALPHA-2

(Mus musculus) 		PF01044
(Vinculin) 		4 ARG A  53
VAL A  59
LEU A  60
ALA A 111
 None
 0.82A 2e1qC-4onsA:
undetectable		 2e1qC-4onsA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 PHE A3136
THR A2636
VAL A2637
LEU A2641
ALA A3133
 None
 1.26A 2e1qC-4qyrA:
undetectable		 2e1qC-4qyrA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r85 CYTOSINE DEAMINASE

(Klebsiella
pneumoniae) 		PF07969
(Amidohydro_3) 		4 ARG A 395
VAL A 114
LEU A 144
ALA A 139
 None
 1.05A 2e1qC-4r85A:
undetectable		 2e1qC-4r85A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rly NAV1.2 - ANKB
CHIMERA

(Homo sapiens;
Mus musculus) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4) 		4 PHE A2035
VAL A2048
LEU A2044
ALA A2038
 None
 0.94A 2e1qC-4rlyA:
undetectable		 2e1qC-4rlyA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxl MOLYBDENUM ABC
TRANSPORTER,
PERIPLASMIC
MOLYBDENUM-BINDING
PROTEIN

(Vibrio cholerae) 		PF13531
(SBP_bac_11) 		4 PHE A 207
VAL A 159
LEU A 163
ALA A 150
 None
 1.06A 2e1qC-4rxlA:
undetectable		 2e1qC-4rxlA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wcj POLYSACCHARIDE
DEACETYLASE

(Ammonifex
degensii) 		PF01522
(Polysacc_deac_1) 		4 ARG A 261
PHE A 244
THR A 112
ALA A 221
 None
 1.06A 2e1qC-4wcjA:
undetectable		 2e1qC-4wcjA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wy5 ESTERASE

(Rhizomucor
miehei) 		PF07859
(Abhydrolase_3) 		4 THR A 114
VAL A 113
LEU A  80
ALA A 110
 None
 1.05A 2e1qC-4wy5A:
undetectable		 2e1qC-4wy5A:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xee NEUROTENSIN RECEPTOR
TYPE 1, ENDOLYSIN
CHIMERA

(Escherichia
virus T4;
Rattus
norvegicus) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 PHE A1153
VAL A1087
LEU A1118
ALA A1129
 None
 1.04A 2e1qC-4xeeA:
0.2		 2e1qC-4xeeA:
18.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ysw XANTHINE
DEHYDROGENASE/OXIDAS
E

(Rattus
norvegicus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 ARG A 880
PHE A 914
THR A1010
LEU A1014
ALA A1079
 URC  A3007 (-3.7A)
URC  A3007 ( 3.4A)
URC  A3007 (-3.5A)
None
URC  A3007 (-3.4A)
 0.24A 2e1qC-4yswA:
45.9		 2e1qC-4yswA:
90.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yxc FLAGELLAR ASSEMBLY
PROTEIN H,ENDOLYSIN

(Escherichia
virus T4;
Salmonella
enterica) 		PF00959
(Phage_lysozyme) 		4 PHE A 174
VAL A 108
LEU A 139
ALA A 150
 None
 1.00A 2e1qC-4yxcA:
undetectable		 2e1qC-4yxcA:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yyf BETA-N-ACETYLHEXOSAM
INIDASE

(Mycolicibacterium
smegmatis) 		PF00933
(Glyco_hydro_3) 		4 ARG A 355
VAL A 330
LEU A 334
ALA A 359
 None
 0.96A 2e1qC-4yyfA:
undetectable		 2e1qC-4yyfA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zk7 DIVALENT-CATION
TOLERANCE PROTEIN
CUTA

(Thermus
thermophilus) 		PF03091
(CutA1) 		4 PHE M  64
VAL M  57
LEU M  22
ALA M  63
 None
 0.97A 2e1qC-4zk7M:
undetectable		 2e1qC-4zk7M:
7.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bz6 LYSOZYME,CALCIUM
UNIPORTER PROTEIN,
MITOCHONDRIAL

(Escherichia
virus T4;
Homo sapiens) 		PF00959
(Phage_lysozyme) 		4 PHE A 153
VAL A  87
LEU A 118
ALA A 129
 None
 1.00A 2e1qC-5bz6A:
undetectable		 2e1qC-5bz6A:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c6u AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF12897
(Aminotran_MocR) 		4 ARG A 392
THR A 374
VAL A 373
ALA A 394
 None
 0.90A 2e1qC-5c6uA:
undetectable		 2e1qC-5c6uA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ccx TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRMT61A

(Homo sapiens) 		PF08704
(GCD14) 		4 ARG A 160
THR A 158
VAL A 157
LEU A 131
 None
 1.05A 2e1qC-5ccxA:
undetectable		 2e1qC-5ccxA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dsg MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 PHE A1110
VAL A1044
LEU A1075
ALA A1086
 None
 0.99A 2e1qC-5dsgA:
undetectable		 2e1qC-5dsgA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8e IGA FAB HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ARG B 176
THR B 174
VAL B 173
LEU B 197
 None
 0.99A 2e1qC-5e8eB:
undetectable		 2e1qC-5e8eB:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5et1 ESPIN

(Mus musculus) 		PF12796
(Ank_2)
PF13637
(Ank_4)
PF13857
(Ank_5) 		4 THR A 326
VAL A 327
LEU A 298
ALA A 309
 None
 1.03A 2e1qC-5et1A:
undetectable		 2e1qC-5et1A:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ewx ENDOLYSIN,IMMUNOGLOB
ULIN G-BINDING
PROTEIN A,ENDOLYSIN

(Escherichia
virus T4;
Staphylococcus
aureus) 		PF00959
(Phage_lysozyme)
PF02216
(B) 		4 PHE A 153
VAL A  87
LEU A 118
ALA A 129
 None
 1.04A 2e1qC-5ewxA:
undetectable		 2e1qC-5ewxA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g51 DWV-VP3-P-DOMAIN

(Deformed wing
virus) 		no annotation 4 ARG A 352
VAL A 393
LEU A 312
ALA A 351
 None
 0.96A 2e1qC-5g51A:
undetectable		 2e1qC-5g51A:
7.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gli ENDOTHELIN RECEPTOR
SUBTYPE-B

(Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 PHE A1110
VAL A1044
LEU A1075
ALA A1086
 None
 1.03A 2e1qC-5gliA:
undetectable		 2e1qC-5gliA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i14 MUTATED AND
TRUNCATED T4
LYSOZYME

(Escherichia
virus T4) 		PF00959
(Phage_lysozyme) 		4 PHE A 110
VAL A  44
LEU A  75
ALA A  86
 None
 0.97A 2e1qC-5i14A:
undetectable		 2e1qC-5i14A:
6.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5if3 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Burkholderia
vietnamiensis) 		PF00106
(adh_short) 		4 THR A  15
VAL A  39
LEU A  60
ALA A 120
 None
 1.03A 2e1qC-5if3A:
undetectable		 2e1qC-5if3A:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jpn COMPLEMENT C4-A

(Homo sapiens) 		PF01759
(NTR)
PF07677
(A2M_recep) 		4 ARG C1498
THR C1517
VAL C1522
LEU C1490
 None
 1.07A 2e1qC-5jpnC:
undetectable		 2e1qC-5jpnC:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxk ASP/GLU-SPECIFIC
DIPEPTIDYL-PEPTIDASE

(Porphyromonas
endodontalis) 		PF10459
(Peptidase_S46) 		4 ARG A 694
VAL A 639
LEU A 598
ALA A 631
 CL  A 801 (-3.8A)
None
CL  A 802 (-4.9A)
None
 1.04A 2e1qC-5jxkA:
undetectable		 2e1qC-5jxkA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m59 PRE-MRNA SPLICING
HELICASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		4 ARG A1640
PHE A1641
THR A1603
LEU A1712
 None
 1.06A 2e1qC-5m59A:
undetectable		 2e1qC-5m59A:
22.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mju EXCITATORY AMINO
ACID TRANSPORTER
1,NEUTRAL AMINO ACID
TRANSPORTER
B(0),EXCITATORY
AMINO ACID
TRANSPORTER 1

(Homo sapiens) 		PF00375
(SDF) 		4 PHE A 392
VAL A 451
LEU A 455
ALA A 389
 None
 0.96A 2e1qC-5mjuA:
undetectable		 2e1qC-5mjuA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msc CARBOXYLIC ACID
REDUCTASE

(Nocardia
iowensis) 		PF00501
(AMP-binding) 		5 ARG A 304
THR A 142
VAL A 141
LEU A 249
ALA A 272
 None
 1.48A 2e1qC-5mscA:
undetectable		 2e1qC-5mscA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5twx BROMODOMAIN-CONTAINI
NG PROTEIN 9

(Homo sapiens) 		PF00439
(Bromodomain) 		4 THR A 220
VAL A 221
LEU A 225
ALA A 212
 7P7  A4000 ( 4.1A)
None
None
7P7  A4000 ( 3.8A)
 1.01A 2e1qC-5twxA:
undetectable		 2e1qC-5twxA:
7.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vb0 FOSFOMYCIN
RESISTANCE PROTEIN
FOSA3

(Escherichia
coli) 		PF00903
(Glyoxalase) 		4 PHE A 104
VAL A  80
LEU A  83
ALA A  89
 None
 1.01A 2e1qC-5vb0A:
undetectable		 2e1qC-5vb0A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdd BCL-2-RELATED
OVARIAN KILLER
PROTEIN

(Gallus gallus) 		no annotation 4 PHE A 115
VAL A 158
LEU A 154
ALA A 111
 None
 0.78A 2e1qC-5wddA:
undetectable		 2e1qC-5wddA:
5.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wyp DNA POLYMERASE III
SUBUNIT BETA

(Caulobacter
vibrioides) 		no annotation 4 THR A 219
VAL A 131
LEU A 136
ALA A 216
 None
 0.90A 2e1qC-5wypA:
undetectable		 2e1qC-5wypA:
4.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xez GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR

(Escherichia
virus T4;
Homo sapiens) 		PF00002
(7tm_2)
PF00959
(Phage_lysozyme)
PF02793
(HRM) 		4 PHE A1153
VAL A1087
LEU A1118
ALA A1129
 None
 1.04A 2e1qC-5xezA:
undetectable		 2e1qC-5xezA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yqr ENDOLYSIN/MEMBRANE-A
NCHORED
LIPID-BINDING
PROTEIN LAM6 FUSION
PROTEIN

(Escherichia
virus T4;
Saccharomyces
cerevisiae) 		no annotation 4 PHE A 153
VAL A  87
LEU A 118
ALA A 129
 None
 1.02A 2e1qC-5yqrA:
undetectable		 2e1qC-5yqrA:
6.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6au1 PUTATIVE HEMIN
STORAGE PROTEIN

(Bordetella
bronchiseptica) 		no annotation 4 PHE A 612
VAL A 576
LEU A 548
ALA A 580
 None
 1.04A 2e1qC-6au1A:
undetectable		 2e1qC-6au1A:
5.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA

(Escherichia
virus T4;
Homo sapiens) 		no annotation 4 PHE A1153
VAL A1087
LEU A1118
ALA A1129
 None
 1.06A 2e1qC-6cm4A:
undetectable		 2e1qC-6cm4A:
5.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eic MYCOBACTERIUM
TUBERCULOSIS
MONOGLYCERIDE LIPASE

(Mycobacterium
tuberculosis) 		no annotation 4 ARG C  52
VAL C 271
LEU C 275
ALA C  56
 None
 0.98A 2e1qC-6eicC:
undetectable		 2e1qC-6eicC:
4.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fwh IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE

(Acanthamoeba
castellanii) 		no annotation 4 PHE A  80
VAL A 109
LEU A 151
ALA A 147
 None
 1.00A 2e1qC-6fwhA:
undetectable		 2e1qC-6fwhA:
undetectable