SIMILAR PATTERNS OF AMINO ACIDS FOR 2E1Q_A_SALA2006_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj2 ADENYLOSUCCINATE
SYNTHETASE

(Arabidopsis
thaliana) 		PF00709
(Adenylsucc_synt) 		4 PHE A  45
VAL A  24
LEU A  37
ALA A  42
 None
 1.03A 2e1qA-1dj2A:
1.2		 2e1qA-1dj2A:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj3 ADENYLOSUCCINATE
SYNTHETASE

(Triticum
aestivum) 		PF00709
(Adenylsucc_synt) 		4 PHE A  44
VAL A  23
LEU A  36
ALA A  41
 None
 1.00A 2e1qA-1dj3A:
1.1		 2e1qA-1dj3A:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ih5 AQUAPORIN-1

(Homo sapiens) 		PF00230
(MIP) 		4 PHE A 197
THR A 109
VAL A 107
ALA A 194
 None
 1.05A 2e1qA-1ih5A:
0.0		 2e1qA-1ih5A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus) 		PF01425
(Amidase) 		4 ARG A 344
THR A 513
VAL A 543
ALA A 341
 None
 1.08A 2e1qA-1mt5A:
undetectable		 2e1qA-1mt5A:
18.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		6 ARG A 880
PHE A 914
THR A1010
VAL A1011
LEU A1014
ALA A1079
 TEI  A3006 (-3.5A)
TEI  A3006 (-3.6A)
TEI  A3006 (-2.8A)
TEI  A3006 (-4.8A)
None
TEI  A3006 ( 3.8A)
 0.30A 2e1qA-1n5xA:
45.7		 2e1qA-1n5xA:
89.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oa1 HYDROXYLAMINE
REDUCTASE

(Desulfovibrio
vulgaris) 		PF03063
(Prismane) 		4 ARG A 171
VAL A  62
LEU A  66
ALA A 162
 None
 0.91A 2e1qA-1oa1A:
0.0		 2e1qA-1oa1A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pby QUINOHEMOPROTEIN
AMINE DEHYDROGENASE
60 KDA SUBUNIT

(Paracoccus
denitrificans) 		PF09098
(Dehyd-heme_bind)
PF09099
(Qn_am_d_aIII)
PF09100
(Qn_am_d_aIV)
PF14930
(Qn_am_d_aII) 		4 THR A 411
VAL A 459
LEU A 476
ALA A 427
 None
 0.93A 2e1qA-1pbyA:
undetectable		 2e1qA-1pbyA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qwj CYTIDINE
MONOPHOSPHO-N-ACETYL
NEURAMINIC ACID
SYNTHETASE

(Mus musculus) 		PF02348
(CTP_transf_3) 		4 PHE A  83
VAL A  73
LEU A 147
ALA A  80
 None
 1.00A 2e1qA-1qwjA:
undetectable		 2e1qA-1qwjA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ug3 EUKARYOTIC PROTEIN
SYNTHESIS INITIATION
FACTOR 4G

(Homo sapiens) 		PF02020
(W2)
PF02847
(MA3) 		4 PHE A1561
VAL A1555
LEU A1516
ALA A1560
 None
 0.93A 2e1qA-1ug3A:
undetectable		 2e1qA-1ug3A:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1us4 PUTATIVE GLUR0
LIGAND BINDING CORE

(Thermus
thermophilus) 		PF16868
(NMT1_3) 		4 ARG A 118
VAL A 134
LEU A 129
ALA A 121
 None
 1.07A 2e1qA-1us4A:
undetectable		 2e1qA-1us4A:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6h DIVALENT CATION
TOLERANCE PROTEIN
CUTA1

(Thermus
thermophilus) 		PF03091
(CutA1) 		4 PHE A  64
VAL A  57
LEU A  22
ALA A  63
 None
 1.01A 2e1qA-1v6hA:
undetectable		 2e1qA-1v6hA:
6.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9p DNA LIGASE

(Thermus
filiformis) 		PF01653
(DNA_ligase_aden)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		4 ARG A 209
THR A 138
VAL A 124
ALA A 205
 None
 1.06A 2e1qA-1v9pA:
2.5		 2e1qA-1v9pA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w45 ANNEXIN A8

(Homo sapiens) 		PF00191
(Annexin) 		4 ARG A 167
THR A 251
VAL A 248
ALA A 121
 None
 1.00A 2e1qA-1w45A:
undetectable		 2e1qA-1w45A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1

(Thermus
thermophilus) 		PF02347
(GDC-P) 		4 PHE A 378
VAL A 366
LEU A 382
ALA A 379
 None
 0.99A 2e1qA-1wytA:
undetectable		 2e1qA-1wytA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcc GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE

(Agrobacterium
fabrum) 		PF03009
(GDPD) 		4 PHE A  19
VAL A  47
LEU A  35
ALA A  22
 None
 1.01A 2e1qA-1zccA:
undetectable		 2e1qA-1zccA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1g ACID PHOSPHATASE

(Francisella
tularensis) 		PF04185
(Phosphoesterase) 		4 ARG A  94
THR A 150
VAL A 151
ALA A  57
 None
 1.05A 2e1qA-2d1gA:
undetectable		 2e1qA-2d1gA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2evr COG0791: CELL
WALL-ASSOCIATED
HYDROLASES
(INVASION-ASSOCIATED
PROTEINS)

(Nostoc
punctiforme) 		PF00877
(NLPC_P60) 		4 PHE A 167
THR A 152
VAL A 225
ALA A 222
 None
 1.06A 2e1qA-2evrA:
undetectable		 2e1qA-2evrA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gas ISOFLAVONE REDUCTASE

(Medicago sativa) 		PF05368
(NmrA) 		4 ARG A 138
VAL A 128
LEU A 126
ALA A 133
 None
 1.08A 2e1qA-2gasA:
undetectable		 2e1qA-2gasA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n57 ACYL CARRIER PROTEIN

(Brucella
melitensis) 		PF00550
(PP-binding) 		4 THR A  40
VAL A  41
LEU A  38
ALA A  35
 None
 0.97A 2e1qA-2n57A:
undetectable		 2e1qA-2n57A:
4.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p8t HYPOTHETICAL PROTEIN
PH0730

(Pyrococcus
horikoshii) 		PF14544
(DUF4443) 		4 PHE A 120
THR A  16
VAL A  17
LEU A  21
 None
 1.02A 2e1qA-2p8tA:
undetectable		 2e1qA-2p8tA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p8u HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
CYTOPLASMIC

(Homo sapiens) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		4 THR A 389
VAL A 388
LEU A 187
ALA A 397
 None
 1.04A 2e1qA-2p8uA:
undetectable		 2e1qA-2p8uA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6u NIKD PROTEIN

(Streptomyces
tendae) 		PF01266
(DAO) 		4 PHE A 132
THR A 310
VAL A 311
LEU A 304
 None
 1.01A 2e1qA-2q6uA:
undetectable		 2e1qA-2q6uA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qnr SEPTIN-2

(Homo sapiens) 		PF00735
(Septin) 		4 ARG A 145
PHE A 126
THR A 291
LEU A 294
 None
 0.93A 2e1qA-2qnrA:
undetectable		 2e1qA-2qnrA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qq4 IRON-SULFUR CLUSTER
BIOSYNTHESIS PROTEIN
ISCU

(Thermus
thermophilus) 		PF01592
(NifU_N) 		4 PHE A  59
THR A  75
LEU A  73
ALA A 129
 None
 0.97A 2e1qA-2qq4A:
4.6		 2e1qA-2qq4A:
7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgj FLAVIN-CONTAINING
MONOOXYGENASE

(Pseudomonas
aeruginosa) 		PF01494
(FAD_binding_3) 		4 ARG A 282
THR A 194
VAL A 193
LEU A 232
 None
 1.06A 2e1qA-2rgjA:
undetectable		 2e1qA-2rgjA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w55 XANTHINE
DEHYDROGENASE

(Rhodobacter
capsulatus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 ARG B 310
PHE B 344
THR B 460
LEU B 464
ALA B 529
 HPA  B1780 (-3.4A)
HPA  B1780 (-3.4A)
HPA  B1780 (-3.6A)
None
HPA  B1780 ( 3.2A)
 0.43A 2e1qA-2w55B:
43.5		 2e1qA-2w55B:
26.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wk1 NOVP

(Actinoalloteichus
cyanogriseus) 		PF05711
(TylF) 		4 ARG A  52
THR A  29
VAL A  30
ALA A  62
 None
 0.98A 2e1qA-2wk1A:
undetectable		 2e1qA-2wk1A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x8x TLR1789 PROTEIN

(Thermosynechococcus
elongatus) 		PF07244
(POTRA)
PF08479
(POTRA_2) 		5 ARG X 226
THR X 224
VAL X 223
LEU X 292
ALA X 280
 None
 1.40A 2e1qA-2x8xX:
undetectable		 2e1qA-2x8xX:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z1a 5'-NUCLEOTIDASE

(Thermus
thermophilus) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		4 ARG A 226
VAL A 260
LEU A 270
ALA A 225
 None
 1.02A 2e1qA-2z1aA:
undetectable		 2e1qA-2z1aA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5r BENZALACETONE
SYNTHASE

(Rheum palmatum) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 ARG A 178
VAL A  12
LEU A 232
ALA A 171
 None
 1.02A 2e1qA-3a5rA:
undetectable		 2e1qA-3a5rA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3chl ALPHA-14 GIARDIN

(Giardia
intestinalis) 		PF00191
(Annexin) 		4 PHE A 249
VAL A 105
LEU A 109
ALA A 246
 None
 0.98A 2e1qA-3chlA:
undetectable		 2e1qA-3chlA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cz5 TWO-COMPONENT
RESPONSE REGULATOR,
LUXR FAMILY

(Aurantimonas
manganoxydans) 		PF00072
(Response_reg) 		4 PHE A  98
VAL A 106
LEU A  83
ALA A 102
 None
 1.08A 2e1qA-3cz5A:
undetectable		 2e1qA-3cz5A:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddm PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Bordetella
bronchiseptica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ARG A  71
THR A  75
VAL A  76
LEU A  77
 None
 1.02A 2e1qA-3ddmA:
1.6		 2e1qA-3ddmA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1s EXODEOXYRIBONUCLEASE
V, SUBUNIT RECD

(Deinococcus
radiodurans) 		PF13538
(UvrD_C_2)
PF13604
(AAA_30)
PF14490
(HHH_4) 		4 PHE A 603
THR A 407
VAL A 408
LEU A 412
 None
 1.08A 2e1qA-3e1sA:
undetectable		 2e1qA-3e1sA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		4 ARG A 140
THR A 138
VAL A 137
LEU A 150
 None
 1.03A 2e1qA-3ecqA:
undetectable		 2e1qA-3ecqA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ffr PHOSPHOSERINE
AMINOTRANSFERASE
SERC

(Cytophaga
hutchinsonii) 		PF00266
(Aminotran_5) 		4 THR A  17
VAL A  18
LEU A  14
ALA A 343
 None
 1.04A 2e1qA-3ffrA:
undetectable		 2e1qA-3ffrA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fw8 RETICULINE OXIDASE

(Eschscholzia
californica) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 PHE A 313
VAL A 281
LEU A 389
ALA A 270
 None
 1.05A 2e1qA-3fw8A:
3.2		 2e1qA-3fw8A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gfh ETHANOLAMINE
UTILIZATION PROTEIN
EUTL

(Escherichia
coli) 		PF00936
(BMC) 		4 PHE A 189
VAL A 152
LEU A 125
ALA A 149
 None
None
None
HG  A 800 (-2.4A)
 0.89A 2e1qA-3gfhA:
undetectable		 2e1qA-3gfhA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn2 2-DEHYDROPANTOATE
2-REDUCTASE

(Geobacter
metallireducens) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		4 ARG A 181
THR A  99
VAL A  73
LEU A  75
 None
 1.06A 2e1qA-3hn2A:
undetectable		 2e1qA-3hn2A:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG

(Clostridium
acetobutylicum) 		PF06838
(Met_gamma_lyase) 		4 PHE A  86
VAL A  93
LEU A  78
ALA A  83
 None
 1.08A 2e1qA-3hvyA:
undetectable		 2e1qA-3hvyA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8o IMMUNOGLOBULIN A1
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ARG H 170
THR H 168
VAL H 167
LEU H 191
 None
 1.03A 2e1qA-3m8oH:
undetectable		 2e1qA-3m8oH:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mem PUTATIVE SIGNAL
TRANSDUCTION PROTEIN

(Marinobacter
hydrocarbonoclasticus) 		PF04073
(tRNA_edit)
PF08668
(HDOD) 		4 THR A 374
VAL A 373
LEU A 313
ALA A 360
 None
 0.91A 2e1qA-3memA:
undetectable		 2e1qA-3memA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvc GLOBIN PROTEIN 6

(Caenorhabditis
elegans) 		PF00042
(Globin) 		4 PHE A 306
THR A 339
VAL A 338
LEU A 279
 HEM  A 500 ( 4.1A)
None
None
None
 0.98A 2e1qA-3mvcA:
2.7		 2e1qA-3mvcA:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqb OXIDOREDUCTASE

(Bradyrhizobium
diazoefficiens) 		PF01408
(GFO_IDH_MocA) 		4 ARG A 156
VAL A 209
LEU A 149
ALA A 153
 None
 1.09A 2e1qA-3oqbA:
undetectable		 2e1qA-3oqbA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pbl D(3) DOPAMINE
RECEPTOR, LYSOZYME
CHIMERA

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 PHE A1153
VAL A1087
LEU A1118
ALA A1129
 None
 0.96A 2e1qA-3pblA:
undetectable		 2e1qA-3pblA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 PHE A1153
VAL A1087
LEU A1118
ALA A1129
 None
 0.99A 2e1qA-3pdsA:
undetectable		 2e1qA-3pdsA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3puk SYNTAXIN-BINDING
PROTEIN 3

(Mus musculus) 		PF00995
(Sec1) 		4 ARG A 240
THR A 247
VAL A 248
LEU A 249
 None
 1.03A 2e1qA-3pukA:
undetectable		 2e1qA-3pukA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae) 		PF08659
(KR) 		4 THR A 189
VAL A 190
LEU A 191
ALA A  53
 None
 0.92A 2e1qA-3qp9A:
undetectable		 2e1qA-3qp9A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rg2 ENTEROBACTIN
SYNTHASE COMPONENT E
(ENTE),
2,3-DIHYDRO-2,3-DIHY
DROXYBENZOATE
SYNTHETASE,
ISOCHROISMATASE
(ENTB)

(Escherichia
coli) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF13193
(AMP-binding_C) 		4 ARG A  66
VAL A  98
LEU A  93
ALA A  62
 None
 0.80A 2e1qA-3rg2A:
undetectable		 2e1qA-3rg2A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rx8 CELLULASE

(Alicyclobacillus
acidocaldarius) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		4 ARG A 275
THR A 320
LEU A 257
ALA A 271
 None
 1.05A 2e1qA-3rx8A:
undetectable		 2e1qA-3rx8A:
18.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		6 ARG C 880
PHE C 914
THR C1010
VAL C1011
LEU C1014
ALA C1079
 None
RMO  C1317 (-3.6A)
None
None
None
RMO  C1317 ( 3.6A)
 0.40A 2e1qA-3sr6C:
53.4		 2e1qA-3sr6C:
61.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3suc PRENECK APPENDAGE
PROTEIN

(Bacillus virus
phi29) 		PF11962
(Peptidase_G2)
PF12708
(Pectate_lyase_3) 		4 ARG A 537
THR A 534
VAL A 535
LEU A 514
 None
 1.04A 2e1qA-3sucA:
undetectable		 2e1qA-3sucA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ut2 CATALASE-PEROXIDASE
2

(Magnaporthe
oryzae) 		PF00141
(peroxidase) 		4 PHE A 699
VAL A 740
LEU A 747
ALA A 751
 None
 0.99A 2e1qA-3ut2A:
undetectable		 2e1qA-3ut2A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ut3 PLASMINOGEN
ACTIVATOR INHIBITOR
1

(Homo sapiens) 		PF00079
(Serpin) 		4 ARG A  18
VAL A  39
LEU A  43
ALA A  61
 None
 1.09A 2e1qA-3ut3A:
undetectable		 2e1qA-3ut3A:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v2y SPHINGOSINE
1-PHOSPHATE RECEPTOR
1, LYSOZYME CHIMERA
(E.C.3.2.1.17)

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 PHE A1153
VAL A1087
LEU A1118
ALA A1129
 None
 1.02A 2e1qA-3v2yA:
undetectable		 2e1qA-3v2yA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4z ANTIVIRAL HELICASE
SKI2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		4 THR A 793
VAL A 792
LEU A 752
ALA A 761
 None
 0.95A 2e1qA-4a4zA:
2.3		 2e1qA-4a4zA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1n CO
DEHYDROGENASE/ACETYL
-COA SYNTHASE,
IRON-SULFUR PROTEIN

(Carboxydothermus
hydrogenoformans) 		PF03599
(CdhD) 		4 THR B 276
VAL B 277
LEU B 213
ALA B 250
 None
 0.92A 2e1qA-4c1nB:
undetectable		 2e1qA-4c1nB:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d3y LEGUMAIN

(Cricetulus
griseus) 		PF01650
(Peptidase_C13) 		4 PHE A 391
VAL A 412
LEU A 416
ALA A 387
 None
 0.84A 2e1qA-4d3yA:
undetectable		 2e1qA-4d3yA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4djh KAPPA-TYPE OPIOID
RECEPTOR, LYSOZYME

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 PHE A1153
VAL A1087
LEU A1118
ALA A1129
 None
 1.07A 2e1qA-4djhA:
undetectable		 2e1qA-4djhA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gax AMORPHA-4,11-DIENE
SYNTHASE

(Artemisia annua) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 ARG A 262
PHE A 525
THR A 296
VAL A 295
 None
 1.08A 2e1qA-4gaxA:
1.9		 2e1qA-4gaxA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jg9 LIPOPROTEIN

(Bacillus
anthracis) 		PF16167
(DUF4871) 		4 THR A 115
VAL A 114
LEU A  47
ALA A  41
 None
 0.99A 2e1qA-4jg9A:
undetectable		 2e1qA-4jg9A:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jkz TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Mycolicibacterium
smegmatis) 		PF00440
(TetR_N)
PF16859
(TetR_C_11) 		4 ARG A 181
THR A  83
VAL A  82
ALA A 180
 None
 1.07A 2e1qA-4jkzA:
undetectable		 2e1qA-4jkzA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 PHE A1018
VAL A 952
LEU A 983
ALA A 994
 None
 1.07A 2e1qA-4ldeA:
undetectable		 2e1qA-4ldeA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n9n STEROL UPTAKE
CONTROL PROTEIN 2,
LYSOZYME

(Escherichia
virus T4;
Saccharomyces
cerevisiae) 		PF00959
(Phage_lysozyme)
PF11951
(Fungal_trans_2) 		4 PHE A1153
VAL A1087
LEU A1118
ALA A1129
 None
 1.08A 2e1qA-4n9nA:
undetectable		 2e1qA-4n9nA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ons CATENIN ALPHA-2

(Mus musculus) 		PF01044
(Vinculin) 		4 ARG A  53
VAL A  59
LEU A  60
ALA A 111
 None
 0.82A 2e1qA-4onsA:
undetectable		 2e1qA-4onsA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ope NRPS/PKS

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 ARG A4405
THR A4485
VAL A4648
LEU A4397
 None
 1.09A 2e1qA-4opeA:
undetectable		 2e1qA-4opeA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p4g SHIKIMATE
5-DEHYDROGENASE AROE
(5-DEHYDROSHIKIMATE
REDUCTASE)

(Mycobacterium
tuberculosis) 		PF08501
(Shikimate_dh_N) 		4 PHE A  75
VAL A  62
LEU A  11
ALA A  72
 None
 1.07A 2e1qA-4p4gA:
undetectable		 2e1qA-4p4gA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p7c TRNA
(MO5U34)-METHYLTRANS
FERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF08003
(Methyltransf_9) 		4 ARG A 135
VAL A 111
LEU A 115
ALA A 139
 None
 1.02A 2e1qA-4p7cA:
undetectable		 2e1qA-4p7cA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q85 RIBOSOMAL PROTEIN
S12
METHYLTHIOTRANSFERAS
E ACCESSORY FACTOR
YCAO

(Escherichia
coli) 		PF02624
(YcaO) 		4 ARG A 286
VAL A 194
LEU A 359
ALA A 276
 APC  A 601 ( 3.1A)
None
None
None
 1.07A 2e1qA-4q85A:
undetectable		 2e1qA-4q85A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r85 CYTOSINE DEAMINASE

(Klebsiella
pneumoniae) 		PF07969
(Amidohydro_3) 		4 ARG A 395
VAL A 114
LEU A 144
ALA A 139
 None
 1.05A 2e1qA-4r85A:
undetectable		 2e1qA-4r85A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rly NAV1.2 - ANKB
CHIMERA

(Homo sapiens;
Mus musculus) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4) 		4 PHE A2035
VAL A2048
LEU A2044
ALA A2038
 None
 0.99A 2e1qA-4rlyA:
undetectable		 2e1qA-4rlyA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxl MOLYBDENUM ABC
TRANSPORTER,
PERIPLASMIC
MOLYBDENUM-BINDING
PROTEIN

(Vibrio cholerae) 		PF13531
(SBP_bac_11) 		4 PHE A 207
VAL A 159
LEU A 163
ALA A 150
 None
 1.08A 2e1qA-4rxlA:
undetectable		 2e1qA-4rxlA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xee NEUROTENSIN RECEPTOR
TYPE 1, ENDOLYSIN
CHIMERA

(Escherichia
virus T4;
Rattus
norvegicus) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 PHE A1153
VAL A1087
LEU A1118
ALA A1129
 None
 1.04A 2e1qA-4xeeA:
undetectable		 2e1qA-4xeeA:
18.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ysw XANTHINE
DEHYDROGENASE/OXIDAS
E

(Rattus
norvegicus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 ARG A 880
PHE A 914
THR A1010
LEU A1014
ALA A1079
 URC  A3007 (-3.7A)
URC  A3007 ( 3.4A)
URC  A3007 (-3.5A)
None
URC  A3007 (-3.4A)
 0.17A 2e1qA-4yswA:
46.1		 2e1qA-4yswA:
90.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yxc FLAGELLAR ASSEMBLY
PROTEIN H,ENDOLYSIN

(Escherichia
virus T4;
Salmonella
enterica) 		PF00959
(Phage_lysozyme) 		4 PHE A 174
VAL A 108
LEU A 139
ALA A 150
 None
 1.00A 2e1qA-4yxcA:
undetectable		 2e1qA-4yxcA:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yyf BETA-N-ACETYLHEXOSAM
INIDASE

(Mycolicibacterium
smegmatis) 		PF00933
(Glyco_hydro_3) 		4 ARG A 355
VAL A 330
LEU A 334
ALA A 359
 None
 0.99A 2e1qA-4yyfA:
undetectable		 2e1qA-4yyfA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zk7 DIVALENT-CATION
TOLERANCE PROTEIN
CUTA

(Thermus
thermophilus) 		PF03091
(CutA1) 		4 PHE M  64
VAL M  57
LEU M  22
ALA M  63
 None
 0.98A 2e1qA-4zk7M:
undetectable		 2e1qA-4zk7M:
7.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bz6 LYSOZYME,CALCIUM
UNIPORTER PROTEIN,
MITOCHONDRIAL

(Escherichia
virus T4;
Homo sapiens) 		PF00959
(Phage_lysozyme) 		4 PHE A 153
VAL A  87
LEU A 118
ALA A 129
 None
 1.01A 2e1qA-5bz6A:
undetectable		 2e1qA-5bz6A:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c59 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Escherichia
coli) 		PF12704
(MacB_PCD) 		4 PHE A  81
VAL A 156
LEU A 108
ALA A 141
 None
 1.08A 2e1qA-5c59A:
2.1		 2e1qA-5c59A:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c6u AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF12897
(Aminotran_MocR) 		4 ARG A 392
THR A 374
VAL A 373
ALA A 394
 None
 0.93A 2e1qA-5c6uA:
undetectable		 2e1qA-5c6uA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dsg MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 PHE A1110
VAL A1044
LEU A1075
ALA A1086
 None
 0.99A 2e1qA-5dsgA:
undetectable		 2e1qA-5dsgA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8e IGA FAB HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ARG B 176
THR B 174
VAL B 173
LEU B 197
 None
 1.03A 2e1qA-5e8eB:
undetectable		 2e1qA-5e8eB:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ec0 ALP7A

(Bacillus
subtilis) 		no annotation 4 PHE A 151
THR A 127
LEU A 129
ALA A 148
 None
 1.01A 2e1qA-5ec0A:
undetectable		 2e1qA-5ec0A:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5et1 ESPIN

(Mus musculus) 		PF12796
(Ank_2)
PF13637
(Ank_4)
PF13857
(Ank_5) 		4 THR A 326
VAL A 327
LEU A 298
ALA A 309
 None
 1.07A 2e1qA-5et1A:
undetectable		 2e1qA-5et1A:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ewx ENDOLYSIN,IMMUNOGLOB
ULIN G-BINDING
PROTEIN A,ENDOLYSIN

(Escherichia
virus T4;
Staphylococcus
aureus) 		PF00959
(Phage_lysozyme)
PF02216
(B) 		4 PHE A 153
VAL A  87
LEU A 118
ALA A 129
 None
 1.05A 2e1qA-5ewxA:
undetectable		 2e1qA-5ewxA:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gli ENDOTHELIN RECEPTOR
SUBTYPE-B

(Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 PHE A1110
VAL A1044
LEU A1075
ALA A1086
 None
 1.03A 2e1qA-5gliA:
undetectable		 2e1qA-5gliA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i14 MUTATED AND
TRUNCATED T4
LYSOZYME

(Escherichia
virus T4) 		PF00959
(Phage_lysozyme) 		4 PHE A 110
VAL A  44
LEU A  75
ALA A  86
 None
 0.98A 2e1qA-5i14A:
undetectable		 2e1qA-5i14A:
6.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5if3 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Burkholderia
vietnamiensis) 		PF00106
(adh_short) 		4 THR A  15
VAL A  39
LEU A  60
ALA A 120
 None
 1.08A 2e1qA-5if3A:
undetectable		 2e1qA-5if3A:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxk ASP/GLU-SPECIFIC
DIPEPTIDYL-PEPTIDASE

(Porphyromonas
endodontalis) 		PF10459
(Peptidase_S46) 		4 ARG A 694
VAL A 639
LEU A 598
ALA A 631
 CL  A 801 (-3.8A)
None
CL  A 802 (-4.9A)
None
 1.06A 2e1qA-5jxkA:
3.3		 2e1qA-5jxkA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m59 PRE-MRNA SPLICING
HELICASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		4 ARG A1640
PHE A1641
THR A1603
LEU A1712
 None
 1.08A 2e1qA-5m59A:
2.7		 2e1qA-5m59A:
22.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mju EXCITATORY AMINO
ACID TRANSPORTER
1,NEUTRAL AMINO ACID
TRANSPORTER
B(0),EXCITATORY
AMINO ACID
TRANSPORTER 1

(Homo sapiens) 		PF00375
(SDF) 		4 PHE A 392
VAL A 451
LEU A 455
ALA A 389
 None
 0.98A 2e1qA-5mjuA:
undetectable		 2e1qA-5mjuA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v88 LYSOZYME,DCN1-LIKE
PROTEIN 1

(Escherichia
virus T4;
Homo sapiens) 		PF00959
(Phage_lysozyme)
PF03556
(Cullin_binding) 		4 PHE A 153
VAL A  87
LEU A 118
ALA A 129
 None
 1.08A 2e1qA-5v88A:
undetectable		 2e1qA-5v88A:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vb0 FOSFOMYCIN
RESISTANCE PROTEIN
FOSA3

(Escherichia
coli) 		PF00903
(Glyoxalase) 		4 PHE A 104
VAL A  80
LEU A  83
ALA A  89
 None
 1.06A 2e1qA-5vb0A:
undetectable		 2e1qA-5vb0A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdd BCL-2-RELATED
OVARIAN KILLER
PROTEIN

(Gallus gallus) 		no annotation 4 PHE A 115
VAL A 158
LEU A 154
ALA A 111
 None
 0.80A 2e1qA-5wddA:
undetectable		 2e1qA-5wddA:
5.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5woy PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE

(Caldanaerobacter
subterraneus) 		no annotation 4 THR A  20
VAL A 147
LEU A 149
ALA A 160
 None
 1.08A 2e1qA-5woyA:
undetectable		 2e1qA-5woyA:
4.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wyp DNA POLYMERASE III
SUBUNIT BETA

(Caulobacter
vibrioides) 		no annotation 4 THR A 219
VAL A 131
LEU A 136
ALA A 216
 None
 0.95A 2e1qA-5wypA:
undetectable		 2e1qA-5wypA:
4.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yqr ENDOLYSIN/MEMBRANE-A
NCHORED
LIPID-BINDING
PROTEIN LAM6 FUSION
PROTEIN

(Escherichia
virus T4;
Saccharomyces
cerevisiae) 		no annotation 4 PHE A 153
VAL A  87
LEU A 118
ALA A 129
 None
 1.02A 2e1qA-5yqrA:
undetectable		 2e1qA-5yqrA:
6.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA

(Escherichia
virus T4;
Homo sapiens) 		no annotation 4 PHE A1153
VAL A1087
LEU A1118
ALA A1129
 None
 1.06A 2e1qA-6cm4A:
undetectable		 2e1qA-6cm4A:
5.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eic MYCOBACTERIUM
TUBERCULOSIS
MONOGLYCERIDE LIPASE

(Mycobacterium
tuberculosis) 		no annotation 4 ARG C  52
VAL C 271
LEU C 275
ALA C  56
 None
 1.01A 2e1qA-6eicC:
undetectable		 2e1qA-6eicC:
4.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fwh IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE

(Acanthamoeba
castellanii) 		no annotation 4 PHE A  80
VAL A 109
LEU A 151
ALA A 147
 None
 1.00A 2e1qA-6fwhA:
undetectable		 2e1qA-6fwhA:
undetectable