SIMILAR PATTERNS OF AMINO ACIDS FOR 2DU8_G_BEZG2352_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cwu ENOYL ACP REDUCTASE

(Brassica napus) 		PF13561
(adh_short_C2) 		4 TYR A 188
TYR A 198
ILE A 244
GLY A 234
 TDB  A 502 (-3.2A)
TDB  A 502 (-4.5A)
None
None
 1.12A 2du8G-1cwuA:
4.7		 2du8G-1cwuA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e8t HEMAGGLUTININ-NEURAM
INIDASE

(Avian
avulavirus 1) 		PF00423
(HN) 		4 TYR A 470
TYR A 526
ILE A 175
GLY A 402
 None
 1.05A 2du8G-1e8tA:
undetectable		 2du8G-1e8tA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fbw ENDO-1,4-BETA-GLUCAN
ASE F

([Clostridium]
cellulolyticum) 		PF02011
(Glyco_hydro_48) 		4 TYR A 300
TYR A 269
ILE A 136
GLY A 151
 None
 1.37A 2du8G-1fbwA:
undetectable		 2du8G-1fbwA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fbw ENDO-1,4-BETA-GLUCAN
ASE F

([Clostridium]
cellulolyticum) 		PF02011
(Glyco_hydro_48) 		4 TYR A 382
TYR A 275
ILE A 314
GLY A 380
 None
GLC  A3095 (-4.7A)
GLC  A3095 ( 4.6A)
None
 1.35A 2du8G-1fbwA:
undetectable		 2du8G-1fbwA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flc HAEMAGGLUTININ-ESTER
ASE-FUSION
GLYCOPROTEIN

(Influenza C
virus) 		PF02710
(Hema_HEFG)
PF03996
(Hema_esterase) 		4 TYR A 103
TYR A 301
ILE A 142
GLY A  86
 None
 1.29A 2du8G-1flcA:
undetectable		 2du8G-1flcA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h14 ENDO-1,4-BETA-XYLANA
SE

(Pseudoalteromonas
haloplanktis) 		PF01270
(Glyco_hydro_8) 		4 TYR A  53
TYR A  63
ILE A  75
GLY A 132
 None
 1.09A 2du8G-1h14A:
undetectable		 2du8G-1h14A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jed SULFATE
ADENYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 TYR A 473
ILE A 398
ARG A 391
GLY A 507
 None
 1.07A 2du8G-1jedA:
2.1		 2du8G-1jedA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nhw ENOYL-ACYL CARRIER
REDUCTASE

(Plasmodium
falciparum) 		PF13561
(adh_short_C2) 		4 TYR A 267
TYR A 277
ILE A 323
GLY A 313
 TCC  A 600 ( 4.0A)
TCC  A 600 (-4.5A)
TCC  A 600 (-4.8A)
None
 1.05A 2du8G-1nhwA:
2.8		 2du8G-1nhwA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nzj HYPOTHETICAL PROTEIN
YADB

(Escherichia
coli) 		PF00749
(tRNA-synt_1c) 		4 TYR A  99
ILE A 163
ARG A 120
GLY A 117
 None
 1.33A 2du8G-1nzjA:
2.0		 2du8G-1nzjA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogp SULFITE OXIDASE

(Arabidopsis
thaliana) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		4 TYR A 241
ILE A 214
ARG A 103
GLY A 375
 MTQ  A1394 (-4.3A)
MTQ  A1394 ( 4.5A)
None
None
 1.20A 2du8G-1ogpA:
undetectable		 2du8G-1ogpA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s4f RNA-DEPENDENT RNA
POLYMERASE

(Pestivirus A) 		PF00998
(RdRP_3) 		4 TYR A 256
ILE A 380
ARG A 399
GLY A 401
 None
 1.03A 2du8G-1s4fA:
undetectable		 2du8G-1s4fA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bdz MEXICAIN

(Jacaratia
mexicana) 		PF00112
(Peptidase_C1) 		4 TYR A 166
TYR A   1
ARG A 191
GLY A 167
 None
 1.36A 2du8G-2bdzA:
undetectable		 2du8G-2bdzA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxi PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Pyrococcus
horikoshii) 		PF03483
(B3_4)
PF03484
(B5) 		4 TYR A 103
TYR A 268
ILE A 273
GLY A 237
 None
 1.37A 2du8G-2cxiA:
undetectable		 2du8G-2cxiA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dul N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE

(Pyrococcus
horikoshii) 		PF02005
(TRM) 		4 TYR A 273
ILE A 250
ARG A 188
GLY A 189
 None
 1.27A 2du8G-2dulA:
3.4		 2du8G-2dulA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2exh BETA-D-XYLOSIDASE

(Geobacillus
stearothermophilus) 		PF04616
(Glyco_hydro_43) 		4 TYR A  41
ILE A  27
ARG A 384
GLY A  11
 None
 1.18A 2du8G-2exhA:
undetectable		 2du8G-2exhA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2foi ENOYL-ACYL CARRIER
REDUCTASE

(Plasmodium
falciparum) 		PF13561
(adh_short_C2) 		4 TYR A 267
TYR A 277
ILE A 323
GLY A 313
 JPA  A 500 (-3.7A)
JPA  A 500 (-4.4A)
JPA  A 500 (-4.1A)
NAD  A 450 (-4.9A)
 1.01A 2du8G-2foiA:
2.8		 2du8G-2foiA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fzv PUTATIVE ARSENICAL
RESISTANCE PROTEIN

(Shigella
flexneri) 		PF03358
(FMN_red) 		4 TYR A 195
ILE A 198
ARG A 188
GLY A 187
 None
 1.00A 2du8G-2fzvA:
3.8		 2du8G-2fzvA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mdi HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2

(Homo sapiens) 		PF00397
(WW) 		4 TYR A  34
TYR A  32
ILE A  31
GLY A   1
 None
 1.09A 2du8G-2mdiA:
undetectable		 2du8G-2mdiA:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q03 UNCHARACTERIZED
PROTEIN

(Shewanella
denitrificans) 		PF11528
(DUF3224) 		4 TYR A  42
TYR A 130
ILE A 132
GLY A  48
 None
 1.08A 2du8G-2q03A:
undetectable		 2du8G-2q03A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r7e COAGULATION FACTOR
VIII

(Homo sapiens) 		PF00754
(F5_F8_type_C)
PF07731
(Cu-oxidase_2) 		4 TYR B2115
TYR B2105
ILE B2145
GLY B2117
 None
 0.92A 2du8G-2r7eB:
undetectable		 2du8G-2r7eB:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2va8 SKI2-TYPE HELICASE

(Sulfolobus
solfataricus) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 TYR A 237
ILE A 353
ARG A 350
GLY A 246
 None
 1.06A 2du8G-2va8A:
undetectable		 2du8G-2va8A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vy0 ENDO-BETA-1,3-GLUCAN
ASE

(Pyrococcus
furiosus) 		PF00722
(Glyco_hydro_16) 		4 TYR A 250
TYR A 193
ILE A 199
GLY A 249
 None
 1.17A 2du8G-2vy0A:
undetectable		 2du8G-2vy0A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3s TAML

(Streptomyces
sp. 307-9) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 TYR A 423
TYR A 402
ILE A 400
GLY A 432
 None
 1.19A 2du8G-2y3sA:
undetectable		 2du8G-2y3sA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8v CLASS III CHITINASE,
PUTATIVE

(Aspergillus
fumigatus) 		PF00704
(Glyco_hydro_18) 		4 TYR A 223
TYR A 208
ILE A 211
GLY A 224
 None
 1.08A 2du8G-2y8vA:
undetectable		 2du8G-2y8vA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzr PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS

(Methanocaldococcus
jannaschii) 		PF01680
(SOR_SNZ)
PF05690
(ThiG) 		4 TYR A 116
TYR A 216
ILE A 224
GLY A 141
 None
 1.07A 2du8G-2yzrA:
undetectable		 2du8G-2yzrA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbm PROTEIN-TYROSINE-PHO
SPHATASE

(Shewanella sp.) 		PF00149
(Metallophos) 		4 TYR A 257
TYR A 260
ILE A 273
GLY A 253
 None
 1.28A 2du8G-2zbmA:
undetectable		 2du8G-2zbmA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3am3 ENOYL-ACP REDUCTASE

(Plasmodium
falciparum) 		PF13561
(adh_short_C2) 		4 TYR A 267
TYR A 277
ILE A 323
GLY A 313
 TCL  A 802 (-3.6A)
TCL  A 802 (-4.4A)
None
NAD  A 801 (-4.8A)
 1.03A 2du8G-3am3A:
4.5		 2du8G-3am3A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bga BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 TYR A 563
TYR A 549
ILE A 578
GLY A 559
 None
 1.38A 2du8G-3bgaA:
undetectable		 2du8G-3bgaA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3chi P-AMINOBENZOATE
N-OXYGENASE

(Streptomyces
thioluteus) 		PF11583
(AurF) 		4 TYR A  93
TYR A  61
ILE A  65
ARG A  96
 None
 1.08A 2du8G-3chiA:
undetectable		 2du8G-3chiA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dec BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 TYR A 539
TYR A 525
ILE A 554
GLY A 535
 None
 1.37A 2du8G-3decA:
undetectable		 2du8G-3decA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwk PENICILLIN-BINDING
PROTEIN 2

(Staphylococcus
aureus) 		PF00905
(Transpeptidase)
PF00912
(Transgly) 		4 TYR A 240
ILE A 239
ARG A  93
GLY A 200
 None
None
SO4  A  22 (-3.5A)
None
 1.28A 2du8G-3dwkA:
undetectable		 2du8G-3dwkA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efv PUTATIVE
SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE

(Salmonella
enterica) 		PF00171
(Aldedh) 		4 TYR A 157
TYR A 186
ILE A 172
GLY A 146
 None
 1.32A 2du8G-3efvA:
3.6		 2du8G-3efvA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehm SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		4 TYR A 277
TYR A 440
ILE A  62
GLY A 276
 None
 1.31A 2du8G-3ehmA:
undetectable		 2du8G-3ehmA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ek5 URIDYLATE KINASE

(Xanthomonas
campestris) 		PF00696
(AA_kinase) 		4 TYR A 186
ILE A 151
ARG A 239
GLY A 238
 None
 1.36A 2du8G-3ek5A:
2.7		 2du8G-3ek5A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewi N-ACYLNEURAMINATE
CYTIDYLYLTRANSFERASE

(Mus musculus) 		no annotation 4 TYR A  26
ILE A  25
ARG A 145
GLY A 144
 None
 1.22A 2du8G-3ewiA:
4.4		 2du8G-3ewiA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f4b ENOYL-ACYL CARRIER
PROTEIN REDUCTASE

(Plasmodium
berghei) 		PF13561
(adh_short_C2) 		4 TYR A 252
TYR A 262
ILE A 308
GLY A 298
 TCL  A 400 (-3.6A)
TCL  A 400 (-4.7A)
None
NAD  A 450 (-4.9A)
 1.11A 2du8G-3f4bA:
4.5		 2du8G-3f4bA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ga7 ACETYL ESTERASE

(Salmonella
enterica) 		PF07859
(Abhydrolase_3) 		4 TYR A 240
TYR A 131
ILE A 135
GLY A 199
 None
 1.05A 2du8G-3ga7A:
undetectable		 2du8G-3ga7A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gec PERIOD CIRCADIAN
PROTEIN

(Drosophila
melanogaster) 		PF00989
(PAS)
PF14598
(PAS_11) 		4 TYR A 264
ILE A 258
ARG A 272
GLY A 271
 None
 0.98A 2du8G-3gecA:
undetectable		 2du8G-3gecA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hwk METHYLCITRATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF00285
(Citrate_synt) 		4 TYR A 340
ILE A 346
ARG A 309
GLY A 257
 None
 1.06A 2du8G-3hwkA:
undetectable		 2du8G-3hwkA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icx PRE MRNA SPLICING
PROTEIN

(Sulfolobus
solfataricus) 		PF01798
(Nop) 		4 TYR A 165
TYR A 182
ILE A 176
GLY A 190
 None
 1.34A 2du8G-3icxA:
undetectable		 2du8G-3icxA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3id6 PRE MRNA SPLICING
PROTEIN

(Sulfolobus
solfataricus) 		PF01798
(Nop) 		4 TYR A 165
TYR A 182
ILE A 176
GLY A 190
 None
 1.33A 2du8G-3id6A:
undetectable		 2du8G-3id6A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 5

(Homo sapiens) 		PF00443
(UCH)
PF00627
(UBA)
PF02148
(zf-UBP) 		4 TYR A 778
TYR A 830
ILE A 571
GLY A 776
 None
 1.23A 2du8G-3ihpA:
undetectable		 2du8G-3ihpA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdu N-FORMIMINO-L-GLUTAM
ATE IMINOHYDROLASE

(Pseudomonas
aeruginosa) 		PF01979
(Amidohydro_1) 		4 TYR A 159
ILE A 177
ARG A 209
GLY A 163
 None
None
NGQ  A 455 (-3.1A)
None
 1.29A 2du8G-3mduA:
undetectable		 2du8G-3mduA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n5m ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Bacillus
anthracis) 		PF00202
(Aminotran_3) 		4 TYR A 128
TYR A 127
ILE A 299
GLY A 246
 None
 1.13A 2du8G-3n5mA:
undetectable		 2du8G-3n5mA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opu SPAP

(Streptococcus
mutans) 		PF16364
(Antigen_C) 		4 TYR A1361
ILE A1457
ARG A1461
GLY A1389
 None
 1.20A 2du8G-3opuA:
undetectable		 2du8G-3opuA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE GAMMA-SUBUNIT

(Komagataella
pastoris) 		no annotation 4 TYR I 292
TYR I 332
ILE I 346
GLY I 326
 None
 1.36A 2du8G-3opyI:
2.2		 2du8G-3opyI:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3plr UDP-GLUCOSE
6-DEHYDROGENASE

(Klebsiella
pneumoniae) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 TYR A 380
ILE A 291
ARG A 283
GLY A 248
 None
 1.18A 2du8G-3plrA:
4.2		 2du8G-3plrA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3plr UDP-GLUCOSE
6-DEHYDROGENASE

(Klebsiella
pneumoniae) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 TYR A 380
ILE A 364
ARG A 283
GLY A 248
 None
 1.32A 2du8G-3plrA:
4.2		 2du8G-3plrA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pop GILR OXIDASE

(Streptomyces
griseoflavus) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		4 TYR A 474
TYR A 470
ILE A 446
GLY A 497
 None
 1.26A 2du8G-3popA:
undetectable		 2du8G-3popA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsm OCCLUSION-DERIVED
VIRUS ENVELOPE
PROTEIN E66

(Autographa
californica
multiple
nucleopolyhedrovirus) 		PF04850
(Baculo_E66) 		4 TYR A 288
TYR A 297
ILE A 328
GLY A 281
 None
 1.25A 2du8G-3vsmA:
undetectable		 2du8G-3vsmA:
19.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3w4k D-AMINO-ACID OXIDASE

(Homo sapiens) 		PF01266
(DAO) 		5 TYR A 224
TYR A 228
ILE A 230
ARG A 283
GLY A 313
 3LD  A 402 (-3.6A)
3LD  A 402 (-3.8A)
None
3LD  A 402 (-3.7A)
3LD  A 402 ( 3.6A)
 0.68A 2du8G-3w4kA:
55.1		 2du8G-3w4kA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crm EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF03464
(eRF1_2)
PF03465
(eRF1_3) 		4 TYR X 198
ILE X 146
ARG X 195
GLY X 150
 None
 1.21A 2du8G-4crmX:
undetectable		 2du8G-4crmX:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dgk PHYTOENE
DEHYDROGENASE

(Pantoea
ananatis) 		PF01593
(Amino_oxidase) 		4 TYR A 136
TYR A 201
ILE A 204
GLY A 135
 None
 1.31A 2du8G-4dgkA:
10.7		 2du8G-4dgkA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4el8 GLYCOSIDE HYDROLASE
FAMILY 48

(Caldicellulosiruptor
bescii) 		PF02011
(Glyco_hydro_48) 		4 TYR A 383
TYR A 273
ILE A 315
GLY A 381
 None
 1.36A 2du8G-4el8A:
undetectable		 2du8G-4el8A:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fir PYRIDOXAL
BIOSYNTHESIS LYASE
PDXS

(Pyrococcus
horikoshii) 		PF01680
(SOR_SNZ)
PF05690
(ThiG) 		4 TYR A 123
TYR A 223
ILE A 231
GLY A 148
 None
 1.09A 2du8G-4firA:
undetectable		 2du8G-4firA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4flm S-FORMYLGLUTATHIONE
HYDROLASE

(Saccharomyces
cerevisiae) 		PF00756
(Esterase) 		4 TYR A 111
TYR A 165
ILE A 189
GLY A 109
 None
None
SDP  A 161 ( 4.7A)
None
 1.01A 2du8G-4flmA:
undetectable		 2du8G-4flmA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE

(Escherichia
coli;
Escherichia
virus Qbeta) 		PF00009
(GTP_EFTU)
PF00889
(EF_TS)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2)
PF03431
(RNA_replicase_B) 		4 TYR A 616
ILE A1239
ARG A 573
GLY A 574
 None
 1.15A 2du8G-4fwtA:
2.7		 2du8G-4fwtA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gb7 6-AMINOHEXANOATE-DIM
ER HYDROLASE

(Bacillus
anthracis) 		PF00144
(Beta-lactamase) 		4 TYR A 403
TYR A 407
ILE A 386
GLY A 373
 None
 1.20A 2du8G-4gb7A:
undetectable		 2du8G-4gb7A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyj RHODOPSIN

(Exiguobacterium
sibiricum) 		PF01036
(Bac_rhodopsin) 		4 TYR A  83
ILE A 123
ARG A 213
GLY A 197
 None
None
None
LFA  A 308 ( 4.0A)
 1.38A 2du8G-4hyjA:
undetectable		 2du8G-4hyjA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jx8 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH] FABI

(Escherichia
coli) 		PF13561
(adh_short_C2) 		4 TYR A 146
TYR A 156
ILE A 200
GLY A 190
 AE6  A 301 ( 4.0A)
AE6  A 301 (-3.8A)
AE6  A 301 (-4.2A)
None
 1.33A 2du8G-4jx8A:
4.5		 2du8G-4jx8A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0v EXONUCLEASE SUBUNIT
SBCD

(Escherichia
coli) 		PF00149
(Metallophos)
PF12320
(SbcD_C) 		4 TYR A 161
TYR A 160
ILE A 137
GLY A 183
 None
 1.02A 2du8G-4m0vA:
undetectable		 2du8G-4m0vA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mmh HEPARINASE III
PROTEIN

(Pedobacter
heparinus) 		PF07940
(Hepar_II_III)
PF16889
(Hepar_II_III_N) 		4 TYR A 306
TYR A 322
ILE A 270
GLY A 307
 None
 1.12A 2du8G-4mmhA:
undetectable		 2du8G-4mmhA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfu SENESCENCE-ASSOCIATE
D CARBOXYLESTERASE
101

(Arabidopsis
thaliana) 		PF01764
(Lipase_3) 		4 TYR B 393
TYR B 394
ILE B 453
GLY B 405
 None
None
None
IPA  B 602 (-4.0A)
 1.33A 2du8G-4nfuB:
undetectable		 2du8G-4nfuB:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nk5 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]

(Candidatus
Liberibacter
asiaticus) 		PF13561
(adh_short_C2) 		4 TYR A 146
TYR A 156
ILE A 200
GLY A 190
 None
 1.17A 2du8G-4nk5A:
5.1		 2du8G-4nk5A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nob POLYMERIC
IMMUNOGLOBULIN
RECEPTOR

(Mus musculus) 		PF07686
(V-set) 		4 TYR A  54
ILE A  95
ARG A  52
GLY A 113
 None
 1.34A 2du8G-4nobA:
undetectable		 2du8G-4nobA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oic BET V I
ALLERGEN-LIKE

(Oryza sativa) 		PF10604
(Polyketide_cyc2) 		4 TYR A  73
ILE A  63
ARG A  94
GLY A  68
 None
 1.06A 2du8G-4oicA:
undetectable		 2du8G-4oicA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ose PUTATIVE HYDROLASE

(Rickettsia
typhi) 		PF00561
(Abhydrolase_1) 		4 TYR A  85
ILE A  20
ARG A  73
GLY A  72
 None
 0.91A 2du8G-4oseA:
undetectable		 2du8G-4oseA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rkk LAFORIN

(Homo sapiens) 		PF00686
(CBM_20)
PF00782
(DSPc) 		4 TYR A 157
TYR A 263
ILE A 186
GLY A  48
 None
 1.30A 2du8G-4rkkA:
undetectable		 2du8G-4rkkA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tr4 TYPE III
IODOTHYRONINE
DEIODINASE

(Mus musculus) 		PF00837
(T4_deiodinase) 		4 TYR A 262
ILE A 269
ARG A 275
GLY A 274
 None
 1.19A 2du8G-4tr4A:
2.4		 2du8G-4tr4A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wz9 AGAP004809-PA

(Anopheles
gambiae) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 TYR A 740
TYR A 708
ILE A 731
GLY A 739
 None
 1.18A 2du8G-4wz9A:
2.3		 2du8G-4wz9A:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x4w CCA TRNA
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL

(Homo sapiens) 		PF01743
(PolyA_pol)
PF12627
(PolyA_pol_RNAbd) 		4 TYR A 179
TYR A 175
ILE A 197
GLY A 187
 None
 1.29A 2du8G-4x4wA:
undetectable		 2du8G-4x4wA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xeu TRANSKETOLASE

(Pseudomonas
aeruginosa) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 TYR A 589
TYR A 622
ILE A 555
GLY A 539
 None
 1.33A 2du8G-4xeuA:
2.5		 2du8G-4xeuA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhj ENVELOPE
GLYCOPROTEIN H

(Human
alphaherpesvirus
3) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		4 TYR A 364
TYR A 365
ILE A 271
GLY A 248
 None
 0.90A 2du8G-4xhjA:
undetectable		 2du8G-4xhjA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwl EXOGLUCANASE S

(Clostridium
cellulovorans) 		PF02011
(Glyco_hydro_48) 		4 TYR A 374
TYR A 267
ILE A 306
GLY A 372
 None
 1.34A 2du8G-4xwlA:
undetectable		 2du8G-4xwlA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN

(Homo sapiens;
Mus musculus;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00339
(Arrestin_N)
PF00959
(Phage_lysozyme)
PF02752
(Arrestin_C)
PF10413
(Rhodopsin_N) 		4 TYR A 192
TYR A 191
ILE A 189
GLY A 182
 None
 1.25A 2du8G-4zwjA:
undetectable		 2du8G-4zwjA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a29 EXOPOLYGALACTURONATE
LYASE

(Vibrio
vulnificus) 		PF06917
(Pectate_lyase_2) 		4 TYR A 367
TYR A 363
ILE A 416
GLY A 372
 EDO  A1579 (-4.9A)
None
None
None
 1.12A 2du8G-5a29A:
undetectable		 2du8G-5a29A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A

(Mus musculus) 		PF00149
(Metallophos) 		4 TYR A 337
TYR A 245
ILE A 202
GLY A 340
 None
 1.37A 2du8G-5fcaA:
undetectable		 2du8G-5fcaA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2h O-METHYLTRANSFERASE
FAMILY 2

(Planctopirus
limnophila) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		4 TYR A 327
TYR A 332
ILE A 296
GLY A 324
 None
 1.24A 2du8G-5i2hA:
3.1		 2du8G-5i2hA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6s ENDOGLUCANASE

(Talaromyces
verruculosus) 		PF00150
(Cellulase) 		4 TYR A 209
TYR A 293
ILE A 292
GLY A 214
 None
 1.37A 2du8G-5i6sA:
undetectable		 2du8G-5i6sA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iuy MULTIDRUG EFFLUX
OUTER MEMBRANE
PROTEIN OPRN

(Pseudomonas
aeruginosa) 		PF02321
(OEP) 		4 TYR A 369
TYR A  25
ILE A 255
GLY A 431
 None
 1.05A 2du8G-5iuyA:
undetectable		 2du8G-5iuyA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jsi BACTERIORHODOPSIN

(Candidatus
Actinomarina
minuta) 		PF01036
(Bac_rhodopsin) 		4 TYR A  70
ILE A 109
ARG A 188
GLY A 175
 None
LYR  A 200 ( 4.8A)
IOD  A 316 (-3.6A)
None
 1.21A 2du8G-5jsiA:
undetectable		 2du8G-5jsiA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jsi BACTERIORHODOPSIN

(Candidatus
Actinomarina
minuta) 		PF01036
(Bac_rhodopsin) 		4 TYR A 192
ILE A 109
ARG A 188
GLY A 175
 None
LYR  A 200 ( 4.8A)
IOD  A 316 (-3.6A)
None
 1.31A 2du8G-5jsiA:
undetectable		 2du8G-5jsiA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8d COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION

(Homo sapiens) 		PF00754
(F5_F8_type_C)
PF07731
(Cu-oxidase_2) 		4 TYR B2115
TYR B2105
ILE B2145
GLY B2117
 None
 0.89A 2du8G-5k8dB:
undetectable		 2du8G-5k8dB:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kis RHS2

(Yersinia
entomophaga) 		no annotation 4 TYR B 584
TYR B 586
ILE B 300
GLY B 295
 None
 1.30A 2du8G-5kisB:
undetectable		 2du8G-5kisB:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5koi ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]

(Brucella
abortus) 		PF13561
(adh_short_C2) 		4 TYR A 147
TYR A 157
ILE A 201
GLY A 191
 NAD  A 300 ( 4.8A)
None
None
None
 1.13A 2du8G-5koiA:
5.5		 2du8G-5koiA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5koj NITROGENASE PROTEIN
ALPHA CHAIN

(Gluconacetobacter
diazotrophicus) 		PF00148
(Oxidored_nitro) 		4 TYR A 370
TYR A 417
ILE A 416
GLY A 372
 None
None
None
ICS  A 502 (-3.5A)
 1.18A 2du8G-5kojA:
2.8		 2du8G-5kojA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5koj NITROGENASE PROTEIN
ALPHA CHAIN

(Gluconacetobacter
diazotrophicus) 		PF00148
(Oxidored_nitro) 		4 TYR A 395
TYR A 403
ILE A 416
GLY A 372
 None
None
None
ICS  A 502 (-3.5A)
 1.32A 2du8G-5kojA:
2.8		 2du8G-5kojA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mju EXCITATORY AMINO
ACID TRANSPORTER
1,NEUTRAL AMINO ACID
TRANSPORTER
B(0),EXCITATORY
AMINO ACID
TRANSPORTER 1

(Homo sapiens) 		PF00375
(SDF) 		4 TYR A 127
TYR A 126
ILE A 473
GLY A 374
 6Z6  A 601 (-4.3A)
None
None
None
 1.25A 2du8G-5mjuA:
undetectable		 2du8G-5mjuA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncl CBK1 KINASE
ACTIVATOR PROTEIN
MOB2

(Saccharomyces
cerevisiae) 		no annotation 4 TYR B 164
TYR B 181
ILE B 182
GLY B 159
 None
 1.34A 2du8G-5nclB:
undetectable		 2du8G-5nclB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5suo EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF12010
(DUF3502) 		4 TYR A 115
TYR A 106
ILE A 107
GLY A 113
 None
 1.20A 2du8G-5suoA:
undetectable		 2du8G-5suoA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ugz PUTATIVE
THIOESTERASE

(Escherichia
coli) 		PF00975
(Thioesterase) 		4 TYR A  67
TYR A   7
ILE A  74
GLY A  70
 None
 1.23A 2du8G-5ugzA:
undetectable		 2du8G-5ugzA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wlz DNA REPAIR PROTEIN
XRCC4,MYOSIN-7

(Homo sapiens) 		no annotation 4 TYR C  84
TYR C  94
ILE C  34
GLY C  77
 None
 1.16A 2du8G-5wlzC:
undetectable		 2du8G-5wlzC:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xd7 3,6-ANHYDRO-ALPHA-L-
GALACTONATE
CYCLOISOMERASE

(Vibrio sp. EJY3) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 TYR A  52
TYR A  50
ILE A 110
GLY A 301
 None
 0.99A 2du8G-5xd7A:
undetectable		 2du8G-5xd7A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xsx CHITINASE

(Thermococcus
chitonophagus) 		no annotation 4 TYR A 431
ILE A 471
ARG A 425
GLY A 426
 None
 1.15A 2du8G-5xsxA:
undetectable		 2du8G-5xsxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN

(Ruminiclostridium
thermocellum) 		no annotation 4 TYR A 410
TYR A 302
ILE A 342
GLY A 408
 None
 1.32A 2du8G-5yj6A:
undetectable		 2du8G-5yj6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cey BIFUNCTIONAL AAC/APH

(Staphylococcus
aureus) 		no annotation 4 TYR A 403
TYR A 440
ILE A 443
GLY A 366
 None
 1.06A 2du8G-6ceyA:
undetectable		 2du8G-6ceyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cr0 (S)-6-HYDROXYNICOTIN
E OXIDASE

(Shinella sp.
HZN7) 		no annotation 4 TYR A 367
ILE A  56
ARG A  37
GLY A  42
 None
None
FAD  A 507 (-4.4A)
FAD  A 507 (-3.1A)
 1.29A 2du8G-6cr0A:
12.5		 2du8G-6cr0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eo5 PPBBE-LIKE 1 D396N

(Physcomitrella
patens) 		no annotation 4 TYR A 472
TYR A 471
ILE A 462
GLY A 229
 None
 1.37A 2du8G-6eo5A:
undetectable		 2du8G-6eo5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f34 AMINO ACID
TRANSPORTER

(Geobacillus
kaustophilus) 		no annotation 4 TYR A  95
TYR A  79
ILE A 257
GLY A  90
 None
 1.21A 2du8G-6f34A:
undetectable		 2du8G-6f34A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f74 ALCOHOL OXIDASE

(Thermothelomyces
thermophila) 		no annotation 4 TYR A 419
TYR A 415
ILE A 225
GLY A 230
 None
None
None
FAD  A 601 (-3.6A)
 1.27A 2du8G-6f74A:
undetectable		 2du8G-6f74A:
undetectable