SIMILAR PATTERNS OF AMINO ACIDS FOR 2DU8_B_BEZB1352

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1akm ORNITHINE
TRANSCARBAMYLASE

(Escherichia
coli) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 LEU A 116
TYR A 105
ILE A  50
GLY A  84
 None
 0.84A 2du8B-1akmA:
4.3		 2du8B-1akmA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6s O-ACETYLSERINE
SULFHYDRYLASE

(Salmonella
enterica) 		PF00291
(PALP) 		4 LEU A  64
TYR A  85
ILE A  49
GLY A  56
 None
 0.94A 2du8B-1d6sA:
1.5		 2du8B-1d6sA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fn9 OUTER-CAPSID PROTEIN
SIGMA 3

(Reovirus sp.) 		PF00979
(Reovirus_cap) 		4 LEU A 228
TYR A 225
ILE A 180
GLY A 350
 None
 0.76A 2du8B-1fn9A:
undetectable		 2du8B-1fn9A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gwi CYTOCHROME P450
154C1

(Streptomyces
coelicolor) 		PF00067
(p450) 		4 LEU A 321
TYR A 318
ILE A 346
ARG A 295
 None
HEM  A1414 (-3.9A)
None
HEM  A1414 (-2.9A)
 0.89A 2du8B-1gwiA:
undetectable		 2du8B-1gwiA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2d ATP SULFURYLASE

(Penicillium
chrysogenum) 		PF01583
(APS_kinase)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 LEU A 323
TYR A 319
ILE A 274
GLY A  76
 None
 0.93A 2du8B-1i2dA:
5.0		 2du8B-1i2dA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iuq GLYCEROL-3-PHOSPHATE
ACYLTRANSFERASE

(Cucurbita
moschata) 		PF01553
(Acyltransferase)
PF14829
(GPAT_N) 		4 LEU A  41
TYR A  45
ILE A 298
GLY A  99
 None
 0.90A 2du8B-1iuqA:
undetectable		 2du8B-1iuqA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1khw RNA-DIRECTED RNA
POLYMERASE

(Rabbit
hemorrhagic
disease virus) 		PF00680
(RdRP_1) 		4 LEU A  99
TYR A  98
ILE A 319
GLY A 219
 None
 0.94A 2du8B-1khwA:
undetectable		 2du8B-1khwA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n61 CARBON MONOXIDE
DEHYDROGENASE MEDIUM
CHAIN

(Oligotropha
carboxidovorans) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		4 LEU C 128
ILE C  94
ARG C 285
GLY C 180
 None
 0.92A 2du8B-1n61C:
undetectable		 2du8B-1n61C:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nw1 CHOLINE KINASE (49.2
KD)

(Caenorhabditis
elegans) 		PF01633
(Choline_kinase) 		4 TYR A 407
TYR A 333
ILE A 335
GLY A 388
 None
 0.88A 2du8B-1nw1A:
undetectable		 2du8B-1nw1A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p8r ARGINASE 1

(Rattus
norvegicus) 		PF00491
(Arginase) 		4 LEU A 179
TYR A 176
ILE A 190
GLY A 142
 None
None
None
S2C  A 551 ( 3.9A)
 0.79A 2du8B-1p8rA:
3.1		 2du8B-1p8rA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		4 LEU A 189
TYR A 187
ILE A 209
GLY A 176
 None
NAG  A 801 (-4.2A)
None
None
 0.79A 2du8B-1q5aA:
undetectable		 2du8B-1q5aA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5d P450 EPOXIDASE

(Sorangium
cellulosum) 		PF00067
(p450) 		4 LEU A 295
TYR A 358
ILE A 300
GLY A 367
 HEM  A 440 ( 4.8A)
HEM  A 440 (-4.4A)
None
HEM  A 440 (-3.6A)
 0.84A 2du8B-1q5dA:
undetectable		 2du8B-1q5dA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sgq STREPTOMYCES GRISEUS
PROTEINASE B

(Streptomyces
griseus) 		PF00089
(Trypsin) 		4 LEU E  85
TYR E 108
ILE E 113
GLY E  18
 None
 0.92A 2du8B-1sgqE:
undetectable		 2du8B-1sgqE:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0l PROBABLE GTPASE ENGC

(Thermotoga
maritima) 		PF03193
(RsgA_GTPase)
PF16745
(RsgA_N) 		4 LEU A 210
TYR A 218
ILE A 165
GLY A   7
 None
 0.89A 2du8B-1u0lA:
undetectable		 2du8B-1u0lA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yad REGULATORY PROTEIN
TENI

(Bacillus
subtilis) 		PF02581
(TMP-TENI) 		4 LEU A   3
TYR A 192
ILE A 179
GLY A 155
 None
None
None
SO4  A 291 ( 4.0A)
 0.95A 2du8B-1yadA:
undetectable		 2du8B-1yadA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zvf 3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE

(Saccharomyces
cerevisiae) 		PF06052
(3-HAO) 		4 LEU A  29
ILE A   9
ARG A 101
GLY A  40
 None
 0.95A 2du8B-1zvfA:
undetectable		 2du8B-1zvfA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a3s MYOCYTE NUCLEAR
FACTOR

(Mus musculus) 		PF00250
(Forkhead) 		4 LEU A  11
TYR A   8
ILE A  29
GLY A  46
 None
 0.86A 2du8B-2a3sA:
undetectable		 2du8B-2a3sA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aqw PUTATIVE
OROTIDINE-MONOPHOSPH
ATE-DECARBOXYLASE

(Plasmodium
yoelii) 		PF00215
(OMPdecase) 		4 LEU A  18
TYR A 312
ILE A 299
GLY A 268
 None
None
None
SO4  A2002 ( 4.9A)
 0.93A 2du8B-2aqwA:
undetectable		 2du8B-2aqwA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epk N-ACETYL-BETA-D-GLUC
OSAMINIDASE

(Streptococcus
gordonii) 		PF00728
(Glyco_hydro_20) 		4 LEU X  65
TYR X  48
ILE X  27
GLY X  72
 None
 0.89A 2du8B-2epkX:
undetectable		 2du8B-2epkX:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5u VIRION PROTEIN UL25

(Human
alphaherpesvirus
1) 		PF01499
(Herpes_UL25) 		4 LEU A 443
TYR A 447
ILE A 140
GLY A 466
 None
 0.70A 2du8B-2f5uA:
undetectable		 2du8B-2f5uA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fzv PUTATIVE ARSENICAL
RESISTANCE PROTEIN

(Shigella
flexneri) 		PF03358
(FMN_red) 		4 TYR A 195
ILE A 198
ARG A 188
GLY A 187
 None
 0.95A 2du8B-2fzvA:
3.9		 2du8B-2fzvA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ghs AGR_C_1268P

(Agrobacterium
fabrum) 		PF08450
(SGL) 		4 LEU A  99
TYR A 312
ILE A 137
GLY A 133
 None
 0.91A 2du8B-2ghsA:
undetectable		 2du8B-2ghsA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2guu ODCASE

(Plasmodium
vivax) 		PF00215
(OMPdecase) 		4 LEU A  36
TYR A 340
ILE A 327
GLY A 296
 None
 0.87A 2du8B-2guuA:
undetectable		 2du8B-2guuA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxg L-ARABINOSE
ISOMERASE

(Escherichia
coli) 		PF02610
(Arabinose_Isome)
PF11762
(Arabinose_Iso_C) 		4 LEU A 396
TYR A 403
ILE A 471
GLY A 203
 None
 0.94A 2du8B-2hxgA:
undetectable		 2du8B-2hxgA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i34 ACID PHOSPHATASE

(Bacillus
anthracis) 		PF03767
(Acid_phosphat_B) 		4 LEU A  66
TYR A 122
ILE A 151
GLY A 142
 WO4  A 401 (-4.1A)
None
None
None
 0.67A 2du8B-2i34A:
undetectable		 2du8B-2i34A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iht CARBOXYETHYLARGININE
SYNTHASE

(Streptomyces
clavuligerus) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 LEU A 498
TYR A 499
ILE A 502
GLY A 270
 None
 0.77A 2du8B-2ihtA:
undetectable		 2du8B-2ihtA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j42 C2 TOXIN
COMPONENT-II

(Clostridium
botulinum) 		PF03495
(Binary_toxB)
PF07691
(PA14)
PF17475
(Binary_toxB_2)
PF17476
(Binary_toxB_3) 		4 LEU A  92
TYR A 115
ILE A  71
GLY A  77
 None
 0.91A 2du8B-2j42A:
undetectable		 2du8B-2j42A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j66 BTRK

(Bacillus
circulans) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 LEU A  34
TYR A 273
ILE A 268
GLY A 230
 None
 0.95A 2du8B-2j66A:
undetectable		 2du8B-2j66A:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		4 LEU A 311
ILE A 313
ARG A 360
GLY A 359
 None
 0.75A 2du8B-2nq5A:
undetectable		 2du8B-2nq5A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1f URIDINE
5'-MONOPHOSPHATE
SYNTHASE

(Homo sapiens) 		PF00215
(OMPdecase) 		4 LEU A  65
TYR A 277
ILE A 264
GLY A 229
 None
 0.86A 2du8B-2p1fA:
undetectable		 2du8B-2p1fA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qcm URIDINE
5'-MONOPHOSPHATE
SYNTHASE (UMP
SYNTHASE)

(Homo sapiens) 		PF00215
(OMPdecase) 		4 LEU A 254
TYR A 466
ILE A 453
GLY A 418
 None
None
None
JW5  A 482 ( 4.9A)
 0.84A 2du8B-2qcmA:
undetectable		 2du8B-2qcmA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt3 N-ISOPROPYLAMMELIDE
ISOPROPYL
AMIDOHYDROLASE

(Pseudomonas sp.
ADP) 		PF01979
(Amidohydro_1) 		4 LEU A 232
TYR A 216
ILE A 214
GLY A 198
 None
 0.85A 2du8B-2qt3A:
undetectable		 2du8B-2qt3A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qz6 BETA-LACTAMASE

(Pseudomonas
fluorescens) 		PF00144
(Beta-lactamase) 		4 LEU A  96
TYR A 135
ILE A 132
GLY A 159
 None
 0.77A 2du8B-2qz6A:
undetectable		 2du8B-2qz6A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wcv L-FUCOSE MUTAROTASE

(Escherichia
coli) 		PF05025
(RbsD_FucU) 		4 LEU A  54
TYR A  89
ILE A 132
GLY A 124
 None
 0.95A 2du8B-2wcvA:
undetectable		 2du8B-2wcvA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9f HEMOLYTIC LECTIN
LSLA

(Laetiporus
sulphureus) 		no annotation 4 LEU A  50
TYR A  52
TYR A  61
ILE A  98
 None
 0.91A 2du8B-2y9fA:
undetectable		 2du8B-2y9fA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2za1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Plasmodium
falciparum) 		PF00215
(OMPdecase) 		4 LEU A  18
TYR A 309
ILE A 296
GLY A 265
 None
 0.92A 2du8B-2za1A:
undetectable		 2du8B-2za1A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3chi P-AMINOBENZOATE
N-OXYGENASE

(Streptomyces
thioluteus) 		PF11583
(AurF) 		5 LEU A 206
TYR A  93
TYR A  61
ILE A  65
ARG A  96
 None
 1.29A 2du8B-3chiA:
undetectable		 2du8B-3chiA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cue TRANSPORT PROTEIN
PARTICLE 31 KDA
SUBUNIT
TRANSPORT PROTEIN
PARTICLE 22 KDA
SUBUNIT

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF04051
(TRAPP)
PF04051
(TRAPP) 		4 LEU B  65
TYR D  34
ILE D  37
GLY D 146
 None
 0.87A 2du8B-3cueB:
undetectable		 2du8B-3cueB:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmk DOWN SYNDROME CELL
ADHESION MOLECULE
(DSCAM) ISOFORM
1.30.30, N-TERMINAL
EIGHT IG DOMAINS

(Drosophila
melanogaster) 		PF07679
(I-set)
PF13927
(Ig_3) 		4 LEU A 457
TYR A 441
ILE A 435
GLY A 468
 None
 0.89A 2du8B-3dmkA:
undetectable		 2du8B-3dmkA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e59 PYOVERDINE
BIOSYNTHESIS PROTEIN
PVCA

(Pseudomonas
aeruginosa) 		PF05141
(DIT1_PvcA) 		4 LEU A  94
ILE A 108
ARG A  22
GLY A 265
 None
 0.93A 2du8B-3e59A:
undetectable		 2du8B-3e59A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fk5 3-OXOACYL-SYNTHASE
III

(Xanthomonas
oryzae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 LEU A 305
ILE A 320
ARG A 313
GLY A 312
 None
 0.88A 2du8B-3fk5A:
undetectable		 2du8B-3fk5A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7k AGMATINE DEIMINASE

(Arabidopsis
thaliana) 		PF04371
(PAD_porph) 		4 LEU A 203
ILE A 118
ARG A  93
GLY A 164
 None
None
None
AGT  A 366 ( 3.5A)
 0.79A 2du8B-3h7kA:
undetectable		 2du8B-3h7kA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i1l HEMAGGLUTININ-ESTERA
SE PROTEIN

(Porcine
torovirus) 		PF02710
(Hema_HEFG)
PF03996
(Hema_esterase) 		4 LEU A 136
TYR A 133
TYR A 137
GLY A 106
 None
 0.87A 2du8B-3i1lA:
undetectable		 2du8B-3i1lA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i27 HEMAGGLUTININ-ESTERA
SE

(Bovine
torovirus) 		PF02710
(Hema_HEFG)
PF03996
(Hema_esterase) 		4 LEU A 127
TYR A 124
TYR A 128
GLY A  97
 None
 0.89A 2du8B-3i27A:
undetectable		 2du8B-3i27A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6k ESTERASE/LIPASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		4 LEU A 106
TYR A  85
ILE A 300
GLY A 159
 None
 0.94A 2du8B-3k6kA:
1.7		 2du8B-3k6kA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kiz PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Cytophaga
hutchinsonii) 		PF02769
(AIRS_C) 		4 LEU A 380
TYR A 392
ILE A 382
GLY A 291
 None
 0.89A 2du8B-3kizA:
undetectable		 2du8B-3kizA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kvt POTASSIUM CHANNEL
PROTEIN SHAW

(Aplysia
californica) 		PF02214
(BTB_2) 		4 LEU A  74
TYR A  76
ILE A  65
GLY A  82
 None
 0.83A 2du8B-3kvtA:
undetectable		 2du8B-3kvtA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdo PUTATIVE
PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Parabacteroides
distasonis) 		PF02769
(AIRS_C) 		4 LEU A 377
TYR A 388
ILE A 379
GLY A 290
 None
 0.90A 2du8B-3mdoA:
undetectable		 2du8B-3mdoA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pk1 INDUCED MYELOID
LEUKEMIA CELL
DIFFERENTIATION
PROTEIN MCL-1

(Homo sapiens) 		PF00452
(Bcl-2) 		4 LEU A 186
TYR A 185
ILE A 294
GLY A 217
 None
 0.89A 2du8B-3pk1A:
undetectable		 2du8B-3pk1A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qye TBC1 DOMAIN FAMILY
MEMBER 1

(Homo sapiens) 		PF00566
(RabGAP-TBC) 		4 LEU A 922
TYR A 926
ILE A 998
GLY A 892
 None
 0.94A 2du8B-3qyeA:
undetectable		 2du8B-3qyeA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sr7 ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE

(Streptococcus
mutans) 		PF01070
(FMN_dh) 		4 LEU A  27
TYR A 319
ILE A  25
GLY A 266
 None
 0.87A 2du8B-3sr7A:
undetectable		 2du8B-3sr7A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v6o LEPTIN RECEPTOR

(Homo sapiens) 		no annotation 4 LEU A 462
TYR A 496
ILE A 432
GLY A 494
 None
EDO  A 708 ( 4.1A)
None
None
 0.93A 2du8B-3v6oA:
undetectable		 2du8B-3v6oA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpy FHA
DOMAIN-CONTAINING
PROTEIN DDL

(Arabidopsis
thaliana) 		PF00498
(FHA) 		4 LEU A  19
TYR A 126
ILE A 117
GLY A  43
 None
 0.94A 2du8B-3vpyA:
undetectable		 2du8B-3vpyA:
17.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3w4k D-AMINO-ACID OXIDASE

(Homo sapiens) 		PF01266
(DAO) 		5 LEU A 215
TYR A 228
ILE A 230
ARG A 283
GLY A 313
 3LD  A 402 (-4.1A)
3LD  A 402 (-3.8A)
None
3LD  A 402 (-3.7A)
3LD  A 402 ( 3.6A)
 0.34A 2du8B-3w4kA:
55.5		 2du8B-3w4kA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrt BETA-LACTAMASE

(Chromohalobacter
sp. 560) 		PF00144
(Beta-lactamase) 		4 LEU A 120
TYR A 151
ILE A 293
GLY A  64
 None
 0.76A 2du8B-3wrtA:
undetectable		 2du8B-3wrtA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx2 ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE 1

(Rattus
norvegicus) 		PF01150
(GDA1_CD39) 		4 LEU A 105
TYR A 104
ILE A 101
GLY A  56
 None
 0.95A 2du8B-3zx2A:
undetectable		 2du8B-3zx2A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ap3 STEROID
MONOOXYGENASE

(Rhodococcus
rhodochrous) 		PF00743
(FMO-like) 		4 LEU A 105
TYR A  79
TYR A 104
ILE A 101
 None
 0.94A 2du8B-4ap3A:
7.0		 2du8B-4ap3A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxs VENOM PROTHROMBIN
ACTIVATOR
PSEUTARIN-C
NON-CATALYTIC
SUBUNIT

(Pseudonaja
textilis) 		PF00754
(F5_F8_type_C)
PF07732
(Cu-oxidase_3) 		4 LEU V 163
TYR V 143
ILE V 165
GLY V1056
 None
 0.92A 2du8B-4bxsV:
undetectable		 2du8B-4bxsV:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czt CBL-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 23

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		4 LEU A 240
TYR A 241
ILE A 244
GLY A 193
 None
 0.82A 2du8B-4cztA:
undetectable		 2du8B-4cztA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d1i BETA-GALACTOSIDASE,
PUTATIVE, BGL35A

(Cellvibrio
japonicus) 		PF02449
(Glyco_hydro_42) 		4 LEU A  51
TYR A  58
ILE A 198
GLY A  62
 None
 0.91A 2du8B-4d1iA:
undetectable		 2du8B-4d1iA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d28 CBL-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 24

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		4 LEU A 218
TYR A 219
ILE A 222
GLY A 171
 None
 0.95A 2du8B-4d28A:
undetectable		 2du8B-4d28A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ddq DNA GYRASE SUBUNIT A

(Bacillus
subtilis) 		PF00521
(DNA_topoisoIV) 		4 LEU A 347
TYR A 234
ILE A 213
GLY A 171
 None
 0.94A 2du8B-4ddqA:
undetectable		 2du8B-4ddqA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4djm DRAB

(Escherichia
coli) 		PF00345
(PapD_N)
PF02753
(PapD_C) 		4 LEU A 145
TYR A  33
ILE A  88
GLY A  92
 None
 0.94A 2du8B-4djmA:
undetectable		 2du8B-4djmA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4es4 PUTATIVE CYCLIC
DI-GMP REGULATOR
CDGR

(Escherichia
coli) 		PF00563
(EAL) 		4 LEU A 121
TYR A 118
ILE A 114
GLY A 129
 None
 0.95A 2du8B-4es4A:
undetectable		 2du8B-4es4A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fom POLIOVIRUS
RECEPTOR-RELATED
PROTEIN 3

(Homo sapiens) 		PF07686
(V-set)
PF08205
(C2-set_2) 		4 LEU A 289
TYR A 336
ILE A 353
GLY A 314
 None
 0.92A 2du8B-4fomA:
undetectable		 2du8B-4fomA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g0b HYDROXYCINNAMOYL-COA
SHIKIMATE/QUINATE
HYDROXYCINNAMOYLTRAN
SFERASE

(Coffea
canephora) 		PF02458
(Transferase) 		5 LEU A 147
TYR A  42
TYR A  40
ILE A 165
GLY A 385
 None
 1.43A 2du8B-4g0bA:
undetectable		 2du8B-4g0bA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrn RHOPTRY KINASE
FAMILY PROTEIN

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		4 LEU A 389
TYR A 388
ILE A 204
ARG A 321
 None
 0.90A 2du8B-4jrnA:
undetectable		 2du8B-4jrnA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4luj OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Methanocaldococcus
jannaschii) 		PF00215
(OMPdecase) 		4 LEU A  24
TYR A 227
ILE A 214
GLY A 187
 None
 0.91A 2du8B-4lujA:
undetectable		 2du8B-4lujA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mjz OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Toxoplasma
gondii) 		PF00215
(OMPdecase) 		4 LEU A  40
TYR A 302
ILE A 289
GLY A 258
 None
 0.85A 2du8B-4mjzA:
undetectable		 2du8B-4mjzA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6c UNCHARACTERIZED
PROTEIN

(Streptococcus
pneumoniae) 		PF08020
(DUF1706) 		4 LEU A 106
TYR A  21
ILE A 110
GLY A 158
 None
 0.94A 2du8B-4n6cA:
undetectable		 2du8B-4n6cA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8s PUTATIVE

(Helicobacter
pylori) 		PF08843
(AbiEii) 		4 LEU A 112
TYR A  95
ILE A 114
GLY A  68
 None
 0.79A 2du8B-4o8sA:
undetectable		 2du8B-4o8sA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ok0 PUTATIVE

(Helicobacter
pylori) 		PF08843
(AbiEii) 		4 LEU A 112
TYR A  95
ILE A 114
GLY A  68
 None
 0.74A 2du8B-4ok0A:
undetectable		 2du8B-4ok0A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3r ARGINASE

(Schistosoma
mansoni) 		PF00491
(Arginase) 		4 LEU A 209
TYR A 206
ILE A 220
GLY A 172
 None
None
None
XA2  A 407 ( 3.8A)
 0.89A 2du8B-4q3rA:
2.4		 2du8B-4q3rA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgi UNCHARACTERIZED
PROTEIN

(Yersinia pestis) 		PF13619
(KTSC) 		4 LEU A  23
TYR A  35
ILE A  25
GLY A  58
 None
 0.84A 2du8B-4rgiA:
undetectable		 2du8B-4rgiA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4weo PUTATIVE
ACETOIN(DIACETYL)
REDUCTASE

(Burkholderia
cenocepacia) 		PF00106
(adh_short) 		4 LEU A 153
TYR A 156
ILE A  95
GLY A 187
 None
 0.79A 2du8B-4weoA:
6.4		 2du8B-4weoA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xeu TRANSKETOLASE

(Pseudomonas
aeruginosa) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 LEU A 601
TYR A 589
TYR A 622
ILE A 555
GLY A 539
 None
 1.20A 2du8B-4xeuA:
2.5		 2du8B-4xeuA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah0 LIPASE

(Pelosinus
fermentans) 		no annotation 4 LEU A 367
TYR A 277
ILE A 174
GLY A 390
 None
 0.88A 2du8B-5ah0A:
undetectable		 2du8B-5ah0A:
25.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b37 TRYPTOPHAN
DEHYDROGENASE

(Nostoc
punctiforme) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 LEU A 270
TYR A 277
ILE A 252
GLY A 237
 None
 0.74A 2du8B-5b37A:
3.7		 2du8B-5b37A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ckm MANNAN-BINDING
LECTIN SERINE
PEPTIDASE 2

(Rattus
norvegicus) 		PF00431
(CUB)
PF07645
(EGF_CA) 		4 LEU A 177
TYR A 194
ILE A 257
GLY A 269
 None
 0.93A 2du8B-5ckmA:
undetectable		 2du8B-5ckmA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlk TQAA

(Penicillium
aethiopicum) 		PF00668
(Condensation) 		4 LEU A 213
TYR A 212
ARG A 314
GLY A 313
 None
 0.87A 2du8B-5dlkA:
undetectable		 2du8B-5dlkA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e3x THERMOSTABLE
CARBOXYPEPTIDASE 1

(Fervidobacterium
islandicum) 		PF02074
(Peptidase_M32) 		4 LEU A 208
TYR A 207
ILE A 252
GLY A 302
 None
 0.94A 2du8B-5e3xA:
undetectable		 2du8B-5e3xA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es6 LINEAR GRAMICIDIN
SYNTHASE SUBUNIT A

(Brevibacillus
parabrevis) 		PF00501
(AMP-binding)
PF00551
(Formyl_trans_N) 		4 LEU A 400
TYR A 439
ILE A 460
GLY A 482
 None
 0.91A 2du8B-5es6A:
3.7		 2du8B-5es6A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es9 LINEAR GRAMICIDIN
SYNTHETASE SUBUNIT A

(Brevibacillus
parabrevis) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00551
(Formyl_trans_N)
PF13193
(AMP-binding_C) 		4 LEU A 400
TYR A 439
ILE A 460
GLY A 482
 None
 0.87A 2du8B-5es9A:
2.9		 2du8B-5es9A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f0l VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 26A

(Homo sapiens) 		PF03643
(Vps26) 		4 LEU B 252
TYR B 185
ILE B 292
GLY B 193
 None
 0.95A 2du8B-5f0lB:
undetectable		 2du8B-5f0lB:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjw VOLTAGE-DEPENDENT
CALCIUM CHANNEL
SUBUNIT
ALPHA-2/DELTA-1

(Oryctolagus
cuniculus) 		PF00092
(VWA)
PF08399
(VWA_N)
PF08473
(VGCC_alpha2) 		4 LEU F 889
TYR F 895
ILE F1019
GLY F 859
 None
 0.92A 2du8B-5gjwF:
2.6		 2du8B-5gjwF:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hwq HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Myxococcus
xanthus) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		4 LEU A 122
TYR A 349
ILE A   7
GLY A 336
 None
 0.91A 2du8B-5hwqA:
undetectable		 2du8B-5hwqA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jnf LINEAR GRAMICIDIN
SYNTHASE SUBUNIT A

(Brevibacillus
parabrevis) 		no annotation 4 LEU C 400
TYR C 439
ILE C 460
GLY C 482
 None
FMT  C 604 (-4.9A)
None
None
 0.90A 2du8B-5jnfC:
3.7		 2du8B-5jnfC:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jnm MANNITOL-1-PHOSPHATE
5-DEHYDROGENASE

(Staphylococcus
aureus) 		no annotation 4 LEU A  40
TYR A  46
ILE A  36
GLY A  14
 None
 0.87A 2du8B-5jnmA:
4.4		 2du8B-5jnmA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jsb INDUCED MYELOID
LEUKEMIA CELL
DIFFERENTIATION
PROTEIN MCL-1

(Homo sapiens) 		PF00452
(Bcl-2) 		4 LEU A 186
TYR A 185
ILE A 294
GLY A 217
 None
 0.88A 2du8B-5jsbA:
undetectable		 2du8B-5jsbA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kju SHIKIMATE
O-HYDROXYCINNAMOYLTR
ANSFERASE

(Arabidopsis
thaliana) 		PF02458
(Transferase) 		5 LEU A 147
TYR A  42
TYR A  40
ILE A 165
GLY A 384
 None
 1.49A 2du8B-5kjuA:
undetectable		 2du8B-5kjuA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kjv HYDROXYCINNAMOYL
TRANSFERASE

(Plectranthus
scutellarioides) 		PF02458
(Transferase) 		5 LEU A 147
TYR A  42
TYR A  40
ILE A 165
GLY A 378
 None
 1.45A 2du8B-5kjvA:
undetectable		 2du8B-5kjvA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kp7 CURD

(Moorea
producens) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		4 LEU A 121
TYR A 335
ILE A   6
GLY A 322
 None
 0.94A 2du8B-5kp7A:
undetectable		 2du8B-5kp7A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l8s AMINO ACYL PEPTIDASE

(Sporosarcina
psychrophila) 		PF00326
(Peptidase_S9) 		4 LEU A 272
TYR A 261
ILE A 305
GLY A 301
 None
 0.94A 2du8B-5l8sA:
undetectable		 2du8B-5l8sA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5min QUINOPROTEIN GLUCOSE
DEHYDROGENASE B

(Acinetobacter
calcoaceticus) 		no annotation 4 LEU A 149
TYR A  95
ILE A 151
GLY A 206
 None
 0.95A 2du8B-5minA:
undetectable		 2du8B-5minA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 LEU A1615
TYR A1618
ILE A1557
GLY A1642
 None
 0.88A 2du8B-5nugA:
undetectable		 2du8B-5nugA:
5.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ool 39S RIBOSOMAL
PROTEIN L37,
MITOCHONDRIAL

(Homo sapiens) 		PF07147
(PDCD9) 		4 LEU 5 382
TYR 5 383
ILE 5 158
ARG 5 173
 None
None
None
A  A2395 ( 3.0A)
 0.95A 2du8B-5ool5:
undetectable		 2du8B-5ool5:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tr1 CHLORIDE CHANNEL
PROTEIN

(Bos taurus) 		PF00654
(Voltage_CLC) 		4 LEU A 139
TYR A 138
ILE A 129
GLY A 204
 None
 0.91A 2du8B-5tr1A:
undetectable		 2du8B-5tr1A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vkq NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L

(Drosophila
melanogaster) 		PF00023
(Ank)
PF00520
(Ion_trans)
PF12796
(Ank_2)
PF13637
(Ank_4) 		4 LEU A1016
TYR A1011
ILE A1007
GLY A 971
 None
 0.93A 2du8B-5vkqA:
undetectable		 2du8B-5vkqA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6any BM4233, ISOFORM B

(Brugia malayi) 		no annotation 4 LEU A 176
TYR A 100
ILE A 166
GLY A 120
 None
 0.67A 2du8B-6anyA:
undetectable		 2du8B-6anyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dm8 -

(-) 		no annotation 4 LEU A 167
TYR A 166
ILE A 275
GLY A 198
 None
None
6AK  A 401 ( 4.9A)
None
 0.91A 2du8B-6dm8A:
undetectable		 2du8B-6dm8A:
undetectable