SIMILAR PATTERNS OF AMINO ACIDS FOR 2DTT_C_H4BC1002_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cii COLICIN IA

(Escherichia
coli) 		PF01024
(Colicin)
PF11504
(Colicin_Ia) 		4 TYR A  30
ASP A  28
THR A 449
GLU A  23
 None
 1.17A 2dttB-1ciiA:
0.6
2dttC-1ciiA:
0.5		 2dttB-1ciiA:
11.33
2dttC-1ciiA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k32 TRICORN PROTEASE

(Thermoplasma
acidophilum) 		PF03572
(Peptidase_S41)
PF07676
(PD40)
PF14684
(Tricorn_C1)
PF14685
(Tricorn_PDZ) 		4 ASP A 227
THR A 985
GLU A1032
GLU A 961
 None
 1.27A 2dttB-1k32A:
1.2
2dttC-1k32A:
1.6		 2dttB-1k32A:
8.45
2dttC-1k32A:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m53 ISOMALTULOSE
SYNTHASE

(Klebsiella sp.
LX3) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 TYR A 105
ASP A 102
PHE A 205
THR A 242
 None
 1.10A 2dttB-1m53A:
0.0
2dttC-1m53A:
0.0		 2dttB-1m53A:
13.43
2dttC-1m53A:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q2e EXOCELLOBIOHYDROLASE
I

(Trichoderma
reesei) 		PF00840
(Glyco_hydro_7) 		4 TYR A 167
ASP A  74
THR A  10
GLU A   9
 None
 1.50A 2dttB-1q2eA:
0.0
2dttC-1q2eA:
0.0		 2dttB-1q2eA:
13.38
2dttC-1q2eA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6v SUBTILISIN-LIKE
SERINE PROTEASE

(Fervidobacterium
pennivorans) 		PF00082
(Peptidase_S8) 		4 TYR A  37
ASP A  34
THR A  81
GLU A  39
 None
 1.03A 2dttB-1r6vA:
0.6
2dttC-1r6vA:
undetectable		 2dttB-1r6vA:
9.16
2dttC-1r6vA:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svi GTP-BINDING PROTEIN
YSXC

(Bacillus
subtilis) 		PF01926
(MMR_HSR1) 		4 TYR A 132
PHE A 129
THR A 101
GLU A  97
 None
 1.40A 2dttB-1sviA:
undetectable
2dttC-1sviA:
0.0		 2dttB-1sviA:
20.20
2dttC-1sviA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svz SINGLE-CHAIN FV
FRAGMENT 1696

(Mus musculus) 		PF07686
(V-set) 		4 TYR A 230
ASP A 229
THR A 235
GLU A 232
 None
 1.46A 2dttB-1svzA:
0.0
2dttC-1svzA:
0.0		 2dttB-1svzA:
15.98
2dttC-1svzA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ur4 GALACTANASE

(Bacillus
licheniformis) 		PF07745
(Glyco_hydro_53) 		4 ASP A 376
PHE A 377
THR A 269
GLU A 271
 None
 1.35A 2dttB-1ur4A:
0.0
2dttC-1ur4A:
0.0		 2dttB-1ur4A:
12.75
2dttC-1ur4A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdt ELONGATION FACTOR G
HOMOLOG

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		4 TYR A 181
ASP A 174
GLU A 188
GLU A 266
 None
 1.29A 2dttB-1wdtA:
0.0
2dttC-1wdtA:
0.0		 2dttB-1wdtA:
10.83
2dttC-1wdtA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x7f OUTER SURFACE
PROTEIN

(Bacillus cereus) 		PF05913
(DUF871) 		4 TYR A 350
ASP A 349
PHE A 346
GLU A 201
 None
 1.08A 2dttB-1x7fA:
undetectable
2dttC-1x7fA:
undetectable		 2dttB-1x7fA:
15.57
2dttC-1x7fA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xnj BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1

(Homo sapiens) 		no annotation 4 ASP B 394
THR B 399
GLU B 402
GLU B 272
 None
 1.16A 2dttB-1xnjB:
undetectable
2dttC-1xnjB:
undetectable		 2dttB-1xnjB:
11.24
2dttC-1xnjB:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z0u PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE

(Archaeoglobus
fulgidus) 		PF01513
(NAD_kinase) 		4 ASP A 135
THR A 221
GLU A 198
GLU A 223
 None
 1.35A 2dttB-1z0uA:
undetectable
2dttC-1z0uA:
undetectable		 2dttB-1z0uA:
17.08
2dttC-1z0uA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zdr DIHYDROFOLATE
REDUCTASE

(Geobacillus
stearothermophilus) 		PF00186
(DHFR_1) 		4 TYR A  30
ASP A  27
PHE A  31
THR A  35
 None
None
SO4  A3486 (-4.1A)
None
 1.28A 2dttB-1zdrA:
undetectable
2dttC-1zdrA:
undetectable		 2dttB-1zdrA:
22.22
2dttC-1zdrA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ayi AMINOPEPTIDASE T

(Thermus
thermophilus) 		PF02073
(Peptidase_M29) 		4 TYR A 352
PHE A 252
GLU A 354
GLU A 250
 None
ZN  A 501 ( 4.8A)
None
ZN  A 501 (-2.3A)
 1.38A 2dttB-2ayiA:
undetectable
2dttC-2ayiA:
undetectable		 2dttB-2ayiA:
14.04
2dttC-2ayiA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ayu NUCLEOSOME ASSEMBLY
PROTEIN

(Saccharomyces
cerevisiae) 		PF00956
(NAP) 		4 ASP A 267
PHE A 253
THR A 251
GLU A 270
 None
 1.32A 2dttB-2ayuA:
undetectable
2dttC-2ayuA:
undetectable		 2dttB-2ayuA:
15.11
2dttC-2ayuA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2blb DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
vivax) 		PF00186
(DHFR_1) 		4 TYR A  56
ASP A  53
PHE A  57
THR A  61
 None
CP7  A1240 (-3.1A)
CP7  A1240 ( 4.1A)
None
 1.21A 2dttB-2blbA:
undetectable
2dttC-2blbA:
undetectable		 2dttB-2blbA:
19.82
2dttC-2blbA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cai GLUTATHIONE
S-TRANSFERASE 28 KDA

(Schistosoma
haematobium) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 TYR A 109
ASP A 172
GLU A 106
GLU A  18
 None
None
None
PG4  A1217 ( 4.9A)
 1.35A 2dttB-2caiA:
undetectable
2dttC-2caiA:
undetectable		 2dttB-2caiA:
19.42
2dttC-2caiA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4e 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
SEMIALDEHYDE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00171
(Aldedh) 		4 ASP A 445
PHE A 281
GLU A 423
GLU A 314
 None
 1.42A 2dttB-2d4eA:
undetectable
2dttC-2d4eA:
undetectable		 2dttB-2d4eA:
11.05
2dttC-2d4eA:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfk COLLYBISTIN II

(Rattus
norvegicus) 		PF00169
(PH)
PF00621
(RhoGEF) 		4 ASP A 314
THR A 346
GLU A 348
GLU A 345
 None
 1.20A 2dttB-2dfkA:
undetectable
2dttC-2dfkA:
undetectable		 2dttB-2dfkA:
15.00
2dttC-2dfkA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpn GLYCEROL KINASE

(Thermus
thermophilus) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 ASP A 242
PHE A 267
GLU A  82
GLU A 300
 None
 1.49A 2dttB-2dpnA:
undetectable
2dttC-2dpnA:
undetectable		 2dttB-2dpnA:
11.31
2dttC-2dpnA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e63 KIAA1787 PROTEIN

(Homo sapiens) 		PF07177
(Neuralized) 		4 ASP A 142
THR A 129
GLU A 127
GLU A 133
 None
 1.23A 2dttB-2e63A:
undetectable
2dttC-2e63A:
undetectable		 2dttB-2e63A:
22.09
2dttC-2e63A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2een HYPOTHETICAL PROTEIN
PH1819

(Pyrococcus
horikoshii) 		PF01928
(CYTH) 		4 ASP A  12
PHE A  15
GLU A 126
GLU A 112
 None
 1.30A 2dttB-2eenA:
undetectable
2dttC-2eenA:
undetectable		 2dttB-2eenA:
23.12
2dttC-2eenA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ja2 GLUTAMYL-TRNA
SYNTHETASE

(Mycobacterium
tuberculosis) 		PF00749
(tRNA-synt_1c) 		4 TYR A 132
ASP A 133
THR A 113
GLU A 116
 None
 1.28A 2dttB-2ja2A:
undetectable
2dttC-2ja2A:
undetectable		 2dttB-2ja2A:
13.18
2dttC-2ja2A:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfn GLUTAMATE RACEMASE

(Escherichia
coli) 		PF01177
(Asp_Glu_race) 		4 ASP A 250
THR A 277
GLU A 276
GLU A 279
 None
 1.25A 2dttB-2jfnA:
undetectable
2dttC-2jfnA:
undetectable		 2dttB-2jfnA:
18.51
2dttC-2jfnA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjq UNCHARACTERIZED RNA
METHYLTRANSFERASE
PYRAB10780

(Pyrococcus
abyssi) 		PF05958
(tRNA_U5-meth_tr) 		4 ASP A 207
PHE A 206
THR A 143
GLU A 146
 None
 1.34A 2dttB-2jjqA:
undetectable
2dttC-2jjqA:
undetectable		 2dttB-2jjqA:
13.92
2dttC-2jjqA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pwh SUCROSE ISOMERASE

([Pseudomonas]
mesoacidophila) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		4 TYR A  64
ASP A  61
PHE A 164
THR A 201
 None
 1.13A 2dttB-2pwhA:
undetectable
2dttC-2pwhA:
undetectable		 2dttB-2pwhA:
11.68
2dttC-2pwhA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qks KIR3.1-PROKARYOTIC
KIR CHANNEL CHIMERA

(Mus musculus;
Paraburkholderia
xenovorans) 		PF01007
(IRK) 		4 PHE A  85
THR A  89
GLU A 112
GLU A  88
 None
 1.43A 2dttB-2qksA:
undetectable
2dttC-2qksA:
undetectable		 2dttB-2qksA:
16.84
2dttC-2qksA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qtp UNCHARACTERIZED
PROTEIN

(Ruegeria
pomeroyi) 		PF06684
(AA_synth) 		4 ASP A 147
THR A  14
GLU A  17
GLU A  12
 None
 1.29A 2dttB-2qtpA:
undetectable
2dttC-2qtpA:
undetectable		 2dttB-2qtpA:
24.38
2dttC-2qtpA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vc6 DIHYDRODIPICOLINATE
SYNTHASE

(Sinorhizobium
meliloti) 		PF00701
(DHDPS) 		4 ASP A 265
PHE A  13
THR A  49
GLU A  46
 None
 1.37A 2dttB-2vc6A:
undetectable
2dttC-2vc6A:
undetectable		 2dttB-2vc6A:
15.36
2dttC-2vc6A:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yb4 AMIDOHYDROLASE

(Chromobacterium
violaceum) 		PF02811
(PHP) 		4 ASP A 127
THR A  20
GLU A  21
GLU A  47
 None
 1.46A 2dttB-2yb4A:
undetectable
2dttC-2yb4A:
undetectable		 2dttB-2yb4A:
17.99
2dttC-2yb4A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yok EXOGLUCANASE 1

(Trichoderma
harzianum) 		PF00840
(Glyco_hydro_7) 		4 TYR A 180
ASP A  90
THR A  27
GLU A  26
 None
 1.44A 2dttB-2yokA:
undetectable
2dttC-2yokA:
undetectable		 2dttB-2yokA:
12.41
2dttC-2yokA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2r NUCLEOSOME ASSEMBLY
PROTEIN

(Saccharomyces
cerevisiae) 		PF00956
(NAP) 		4 ASP A 267
PHE A 253
THR A 251
GLU A 270
 None
 1.41A 2dttB-2z2rA:
undetectable
2dttC-2z2rA:
undetectable		 2dttB-2z2rA:
19.84
2dttC-2z2rA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a98 DEDICATOR OF
CYTOKINESIS PROTEIN
2

(Homo sapiens) 		PF07653
(SH3_2)
PF16172
(DOCK_N) 		4 ASP A 162
THR A  94
GLU A  97
GLU A  90
 None
 1.38A 2dttB-3a98A:
undetectable
2dttC-3a98A:
undetectable		 2dttB-3a98A:
21.93
2dttC-3a98A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3brq HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ASCG

(Escherichia
coli) 		PF13377
(Peripla_BP_3) 		4 ASP A 235
THR A 254
GLU A  36
GLU A 255
 None
 1.31A 2dttB-3brqA:
undetectable
2dttC-3brqA:
undetectable		 2dttB-3brqA:
16.89
2dttC-3brqA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c9h ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN

(Agrobacterium
fabrum) 		PF13416
(SBP_bac_8) 		4 PHE A  24
THR A  48
GLU A  52
GLU A  44
 None
 1.41A 2dttB-3c9hA:
undetectable
2dttC-3c9hA:
undetectable		 2dttB-3c9hA:
14.40
2dttC-3c9hA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dg8 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
falciparum) 		PF00186
(DHFR_1) 		4 TYR A  57
ASP A  54
PHE A  58
THR A  62
 None
RJ6  A 609 (-3.0A)
RJ6  A 609 (-4.3A)
None
 1.24A 2dttB-3dg8A:
undetectable
2dttC-3dg8A:
undetectable		 2dttB-3dg8A:
15.25
2dttC-3dg8A:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmk DOWN SYNDROME CELL
ADHESION MOLECULE
(DSCAM) ISOFORM
1.30.30, N-TERMINAL
EIGHT IG DOMAINS

(Drosophila
melanogaster) 		PF07679
(I-set)
PF13927
(Ig_3) 		4 TYR A 158
ASP A 155
THR A 142
GLU A 144
 None
 1.47A 2dttB-3dmkA:
undetectable
2dttC-3dmkA:
undetectable		 2dttB-3dmkA:
10.18
2dttC-3dmkA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fbu ACETYLTRANSFERASE,
GNAT FAMILY

(Bacillus
anthracis) 		PF13302
(Acetyltransf_3) 		4 TYR A  78
THR A 123
GLU A  85
GLU A 159
 None
 0.99A 2dttB-3fbuA:
undetectable
2dttC-3fbuA:
undetectable		 2dttB-3fbuA:
25.15
2dttC-3fbuA:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3flo DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A

(Saccharomyces
cerevisiae) 		PF08996
(zf-DNA_Pol) 		4 TYR B1410
ASP B1416
THR B1282
GLU B1284
 None
 1.37A 2dttB-3floB:
undetectable
2dttC-3floB:
undetectable		 2dttB-3floB:
15.46
2dttC-3floB:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbd SUCROSE ISOMERASE
SMUA FROM
PROTAMINOBACTER
RUBRUM

(Serratia
plymuthica) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 TYR A  78
ASP A  75
PHE A 178
THR A 215
 EDO  A8003 ( 4.4A)
EDO  A8003 (-2.8A)
EDO  A8003 ( 3.9A)
EDO  A8001 ( 4.2A)
 1.16A 2dttB-3gbdA:
undetectable
2dttC-3gbdA:
undetectable		 2dttB-3gbdA:
11.89
2dttC-3gbdA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gpu DNA GLYCOSYLASE

(Geobacillus
stearothermophilus) 		PF01149
(Fapy_DNA_glyco)
PF06827
(zf-FPG_IleRS)
PF06831
(H2TH) 		4 TYR A 240
THR A 210
GLU A 179
GLU A 213
 None
 1.43A 2dttB-3gpuA:
undetectable
2dttC-3gpuA:
undetectable		 2dttB-3gpuA:
18.22
2dttC-3gpuA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i27 HEMAGGLUTININ-ESTERA
SE

(Bovine
torovirus) 		PF02710
(Hema_HEFG)
PF03996
(Hema_esterase) 		4 TYR A 248
ASP A 247
THR A 121
GLU A 118
 None
 1.22A 2dttB-3i27A:
undetectable
2dttC-3i27A:
undetectable		 2dttB-3i27A:
12.57
2dttC-3i27A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2s COAGULATION FACTOR
VIII LIGHT CHAIN

(Homo sapiens) 		PF00754
(F5_F8_type_C)
PF07731
(Cu-oxidase_2) 		4 ASP B1831
PHE B1830
THR B1964
GLU B1970
 None
 1.27A 2dttB-3j2sB:
undetectable
2dttC-3j2sB:
undetectable		 2dttB-3j2sB:
11.77
2dttC-3j2sB:
11.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l07 BIFUNCTIONAL PROTEIN
FOLD

(Francisella
tularensis) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		4 TYR A 271
THR A 147
GLU A 268
GLU A 151
 EDO  A 506 (-3.5A)
EDO  A 506 ( 3.5A)
EDO  A 506 (-2.8A)
None
 1.35A 2dttB-3l07A:
undetectable
2dttC-3l07A:
undetectable		 2dttB-3l07A:
18.79
2dttC-3l07A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2t PUTATIVE
OXIDOREDUCTASE

(Gluconobacter
oxydans) 		PF00248
(Aldo_ket_red) 		4 ASP A 114
THR A  83
GLU A  65
GLU A 127
 None
 1.20A 2dttB-3n2tA:
undetectable
2dttC-3n2tA:
undetectable		 2dttB-3n2tA:
18.83
2dttC-3n2tA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nra ASPARTATE
AMINOTRANSFERASE

(Rhodobacter
sphaeroides) 		PF00155
(Aminotran_1_2) 		4 TYR A 338
PHE A 371
THR A 366
GLU A 370
 None
 1.46A 2dttB-3nraA:
undetectable
2dttC-3nraA:
undetectable		 2dttB-3nraA:
15.10
2dttC-3nraA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE ALPHA-SUBUNIT

(Komagataella
pastoris) 		PF00365
(PFK) 		4 ASP A 675
THR A 702
GLU A 706
GLU A 699
 None
None
None
SO4  A 998 ( 4.7A)
 1.26A 2dttB-3opyA:
undetectable
2dttC-3opyA:
undetectable		 2dttB-3opyA:
8.46
2dttC-3opyA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p27 ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3) 		4 ASP A 319
THR A 365
GLU A 367
GLU A 357
 None
 1.40A 2dttB-3p27A:
undetectable
2dttC-3p27A:
undetectable		 2dttB-3p27A:
13.18
2dttC-3p27A:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3plr UDP-GLUCOSE
6-DEHYDROGENASE

(Klebsiella
pneumoniae) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 ASP A 126
PHE A 123
THR A  94
GLU A  98
 None
 1.43A 2dttB-3plrA:
undetectable
2dttC-3plrA:
undetectable		 2dttB-3plrA:
15.57
2dttC-3plrA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppo GLYCINE
BETAINE/CARNITINE/CH
OLINE-BINDING
PROTEIN

(Bacillus
subtilis) 		PF04069
(OpuAC) 		4 ASP A 134
PHE A 133
THR A  89
GLU A  43
 None
 1.12A 2dttB-3ppoA:
undetectable
2dttC-3ppoA:
undetectable		 2dttB-3ppoA:
19.93
2dttC-3ppoA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppo GLYCINE
BETAINE/CARNITINE/CH
OLINE-BINDING
PROTEIN

(Bacillus
subtilis) 		PF04069
(OpuAC) 		4 TYR A 203
ASP A 282
THR A 219
GLU A  43
 None
 1.44A 2dttB-3ppoA:
undetectable
2dttC-3ppoA:
undetectable		 2dttB-3ppoA:
19.93
2dttC-3ppoA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r2i EXOTOXIN 5

(Staphylococcus
aureus) 		PF02876
(Stap_Strp_tox_C)
PF09199
(SSL_OB) 		4 TYR A  94
ASP A  90
THR A 123
GLU A 162
 None
 1.44A 2dttB-3r2iA:
undetectable
2dttC-3r2iA:
undetectable		 2dttB-3r2iA:
18.88
2dttC-3r2iA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3trp CALSEQUESTRIN-1

(Oryctolagus
cuniculus) 		PF01216
(Calsequestrin) 		4 ASP A 291
THR A 114
GLU A 109
GLU A 117
 None
None
CA  A 362 (-2.7A)
None
 1.22A 2dttB-3trpA:
undetectable
2dttC-3trpA:
undetectable		 2dttB-3trpA:
15.79
2dttC-3trpA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7b ENDO-1,4-BETA-XYLANA
SE

(Fusarium
oxysporum) 		PF00331
(Glyco_hydro_10) 		4 TYR A 170
ASP A 240
THR A 124
GLU A  78
 None
 1.42A 2dttB-3u7bA:
undetectable
2dttC-3u7bA:
undetectable		 2dttB-3u7bA:
17.39
2dttC-3u7bA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulk KETOL-ACID
REDUCTOISOMERASE

(Escherichia
coli) 		PF01450
(IlvC)
PF07991
(IlvN) 		4 ASP A 356
PHE A 355
THR A 260
GLU A 351
 ASP  A 356 ( 0.6A)
PHE  A 355 ( 1.3A)
THR  A 260 ( 0.8A)
GLU  A 351 ( 0.5A)
 1.48A 2dttB-3ulkA:
undetectable
2dttC-3ulkA:
undetectable		 2dttB-3ulkA:
14.26
2dttC-3ulkA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3um6 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
falciparum) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		4 TYR A  57
ASP A  54
PHE A  58
THR A  62
 None
1CY  A 609 (-2.9A)
1CY  A 609 (-3.5A)
None
 1.28A 2dttB-3um6A:
undetectable
2dttC-3um6A:
undetectable		 2dttB-3um6A:
10.82
2dttC-3um6A:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w3s TYPE-2 SERINE--TRNA
LIGASE

(Methanopyrus
kandleri) 		PF00587
(tRNA-synt_2b) 		4 ASP A 328
PHE A 464
THR A 255
GLU A 324
 None
 1.37A 2dttB-3w3sA:
undetectable
2dttC-3w3sA:
undetectable		 2dttB-3w3sA:
12.38
2dttC-3w3sA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrt BETA-LACTAMASE

(Chromohalobacter
sp. 560) 		PF00144
(Beta-lactamase) 		4 TYR A  93
ASP A  85
THR A 163
GLU A 162
 None
 1.35A 2dttB-3wrtA:
undetectable
2dttC-3wrtA:
undetectable		 2dttB-3wrtA:
16.29
2dttC-3wrtA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wy2 ALPHA-GLUCOSIDASE

(Halomonas sp.
H11) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		4 TYR A  65
ASP A  62
PHE A 166
THR A 203
 BGC  A 605 (-3.7A)
BGC  A 605 (-2.7A)
BGC  A 605 ( 3.8A)
BGC  A 605 ( 4.2A)
 1.26A 2dttB-3wy2A:
undetectable
2dttC-3wy2A:
undetectable		 2dttB-3wy2A:
14.55
2dttC-3wy2A:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b1l LEVANASE

(Bacillus
subtilis) 		PF06439
(DUF1080) 		4 ASP A 643
THR A 559
GLU A 561
GLU A 631
 None
 1.46A 2dttB-4b1lA:
undetectable
2dttC-4b1lA:
undetectable		 2dttB-4b1lA:
20.12
2dttC-4b1lA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b1m LEVANASE

(Bacillus
subtilis) 		PF06439
(DUF1080) 		4 ASP A 643
THR A 559
GLU A 561
GLU A 631
 None
 1.18A 2dttB-4b1mA:
undetectable
2dttC-4b1mA:
undetectable		 2dttB-4b1mA:
20.53
2dttC-4b1mA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4chg PROBABLE
RIBONUCLEASE VAPC15

(Mycobacterium
tuberculosis) 		PF01850
(PIN) 		4 TYR A 117
ASP A 116
THR A   5
GLU A  42
 None
MN  A1133 (-3.0A)
None
MG  A1134 ( 3.8A)
 0.99A 2dttB-4chgA:
undetectable
2dttC-4chgA:
undetectable		 2dttB-4chgA:
20.29
2dttC-4chgA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ctd OUTER MEMBRANE
PROTEIN G

(Escherichia
coli) 		PF09381
(Porin_OmpG) 		4 ASP A 220
PHE A 221
THR A 190
GLU A 192
 None
 1.27A 2dttB-4ctdA:
undetectable
2dttC-4ctdA:
2.1		 2dttB-4ctdA:
23.83
2dttC-4ctdA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d51 CYMA

(Klebsiella
oxytoca) 		PF16941
(CymA) 		4 ASP A   3
THR A  48
GLU A  32
GLU A  74
 None
 1.31A 2dttB-4d51A:
0.9
2dttC-4d51A:
1.0		 2dttB-4d51A:
16.24
2dttC-4d51A:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d51 CYMA

(Klebsiella
oxytoca) 		PF16941
(CymA) 		4 ASP A   3
THR A  50
GLU A  30
GLU A  74
 None
 1.15A 2dttB-4d51A:
0.9
2dttC-4d51A:
1.0		 2dttB-4d51A:
16.24
2dttC-4d51A:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d51 CYMA

(Klebsiella
oxytoca) 		PF16941
(CymA) 		4 ASP A   3
THR A 315
GLU A  30
GLU A 289
 None
 1.39A 2dttB-4d51A:
0.9
2dttC-4d51A:
1.0		 2dttB-4d51A:
16.24
2dttC-4d51A:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gk8 HISTIDINOL-PHOSPHATA
SE

(Lactococcus
lactis) 		PF02811
(PHP) 		4 ASP A  17
THR A  40
GLU A  41
GLU A  81
 ZN  A 302 ( 2.2A)
None
None
ZN  A 301 (-2.5A)
 1.44A 2dttB-4gk8A:
undetectable
2dttC-4gk8A:
undetectable		 2dttB-4gk8A:
19.71
2dttC-4gk8A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gqo LMO0859 PROTEIN

(Listeria
monocytogenes) 		PF13416
(SBP_bac_8) 		4 ASP A 304
THR A 244
GLU A 241
GLU A 248
 None
 1.48A 2dttB-4gqoA:
undetectable
2dttC-4gqoA:
undetectable		 2dttB-4gqoA:
11.75
2dttC-4gqoA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hoz SUCROSE ISOMERASE

(Erwinia
rhapontici) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 TYR A 105
ASP A 102
PHE A 205
THR A 242
 GLC  A 703 (-3.5A)
GLC  A 703 (-2.7A)
GLC  A 703 (-3.7A)
None
 1.15A 2dttB-4hozA:
undetectable
2dttC-4hozA:
undetectable		 2dttB-4hozA:
14.29
2dttC-4hozA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4knh NUP192P

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		4 ASP A 431
THR A 289
GLU A 335
GLU A 295
 SO4  A1001 ( 4.9A)
SO4  A1001 ( 4.5A)
SO4  A1001 (-3.2A)
None
 1.28A 2dttB-4knhA:
undetectable
2dttC-4knhA:
undetectable		 2dttB-4knhA:
8.57
2dttC-4knhA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mt6 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 9

(Rattus
norvegicus) 		PF00018
(SH3_1)
PF00169
(PH)
PF00621
(RhoGEF) 		4 ASP A 374
THR A 406
GLU A 408
GLU A 405
 None
 1.21A 2dttB-4mt6A:
undetectable
2dttC-4mt6A:
undetectable		 2dttB-4mt6A:
14.99
2dttC-4mt6A:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p5x CALCIUM-BINDING
MITOCHONDRIAL
CARRIER PROTEIN
ARALAR1

(Homo sapiens) 		no annotation 4 TYR A 272
ASP A 276
THR A 285
GLU A 247
 None
 1.48A 2dttB-4p5xA:
undetectable
2dttC-4p5xA:
undetectable		 2dttB-4p5xA:
15.34
2dttC-4p5xA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pe8 TAT-LINKED QUALITY
CONTROL PROTEIN TATD

(Escherichia
coli) 		PF01026
(TatD_DNase) 		4 ASP A 130
THR A 157
GLU A 160
GLU A 185
 None
 1.23A 2dttB-4pe8A:
undetectable
2dttC-4pe8A:
undetectable		 2dttB-4pe8A:
19.07
2dttC-4pe8A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1v PUTATIVE DIPEPTIDYL
AMINOPEPTIDASE IV

(Bacteroides
ovatus) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 ASP A 262
THR A 646
GLU A 641
GLU A 648
 None
 1.36A 2dttB-4q1vA:
undetectable
2dttC-4q1vA:
undetectable		 2dttB-4q1vA:
10.79
2dttC-4q1vA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w2q ANTI-MARBURGVIRUS
NUCLEOPROTEIN SINGLE
DOMAIN ANTIBODY C
NUCLEOPROTEIN

(Lama glama;
Marburg
marburgvirus) 		no annotation 4 ASP B 679
PHE A  29
GLU B 687
GLU A  97
 None
 1.24A 2dttB-4w2qB:
undetectable
2dttC-4w2qB:
undetectable		 2dttB-4w2qB:
16.24
2dttC-4w2qB:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xeb GLUCANASE

(Talaromyces
funiculosus) 		PF00840
(Glyco_hydro_7) 		4 TYR A 164
ASP A  74
THR A  10
GLU A   9
 None
 1.46A 2dttB-4xebA:
undetectable
2dttC-4xebA:
undetectable		 2dttB-4xebA:
14.02
2dttC-4xebA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xqk LLABIII

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII)
PF13156
(Mrr_cat_2) 		4 TYR A1037
ASP A1041
THR A 986
GLU A 987
 None
 1.48A 2dttB-4xqkA:
undetectable
2dttC-4xqkA:
undetectable		 2dttB-4xqkA:
5.55
2dttC-4xqkA:
5.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yoo RETINOBLASTOMA-LIKE
PROTEIN
1,RETINOBLASTOMA-LIK
E PROTEIN 1

(Homo sapiens) 		PF01857
(RB_B)
PF01858
(RB_A) 		4 TYR A 849
PHE A 848
THR A 860
GLU A 858
 None
 1.48A 2dttB-4yooA:
undetectable
2dttC-4yooA:
1.9		 2dttB-4yooA:
15.48
2dttC-4yooA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zng PROLIDASE

(Lactococcus
lactis) 		no annotation 4 ASP C 301
THR C 125
GLU C 129
GLU C 100
 None
 1.46A 2dttB-4zngC:
undetectable
2dttC-4zngC:
undetectable		 2dttB-4zngC:
16.02
2dttC-4zngC:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5amp CELLOBIOHYDROLASE I

(Galactomyces
candidus) 		PF00840
(Glyco_hydro_7) 		4 TYR A 167
ASP A  74
THR A  10
GLU A   9
 None
 1.45A 2dttB-5ampA:
undetectable
2dttC-5ampA:
undetectable		 2dttB-5ampA:
12.87
2dttC-5ampA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bmq ERFK/YBIS/YCFS/YNHG
FAMILY PROTEIN

(Stackebrandtia
nassauensis) 		PF03734
(YkuD) 		4 ASP A 133
PHE A 131
THR A 129
GLU A 139
 None
 1.17A 2dttB-5bmqA:
undetectable
2dttC-5bmqA:
undetectable		 2dttB-5bmqA:
17.84
2dttC-5bmqA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dl5 MEMBRANE PROTEIN

(Acinetobacter
baumannii) 		PF03573
(OprD) 		4 TYR A 397
ASP A 310
PHE A 311
GLU A 361
 None
 1.39A 2dttB-5dl5A:
0.4
2dttC-5dl5A:
1.3		 2dttB-5dl5A:
11.22
2dttC-5dl5A:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dx9 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE

(Cryptococcus
neoformans) 		PF02358
(Trehalose_PPase) 		4 ASP A  26
THR A 138
GLU A 180
GLU A 131
 T6P  A 402 ( 2.9A)
T6P  A 402 (-3.1A)
T6P  A 402 (-2.7A)
T6P  A 402 (-2.4A)
 1.46A 2dttB-5dx9A:
undetectable
2dttC-5dx9A:
undetectable		 2dttB-5dx9A:
19.30
2dttC-5dx9A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fku DNA POLYMERASE III
SUBUNIT ALPHA

(Escherichia
coli) 		PF01336
(tRNA_anti-codon)
PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 ASP A 790
THR A 606
GLU A 612
GLU A 803
 None
 1.38A 2dttB-5fkuA:
undetectable
2dttC-5fkuA:
undetectable		 2dttB-5fkuA:
6.64
2dttC-5fkuA:
6.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fqe BETA-N-ACETYLGALACTO
SAMINIDASE

(Clostridium
perfringens) 		PF13320
(DUF4091) 		4 TYR A 383
ASP A 387
THR A 411
GLU A 415
 None
 1.50A 2dttB-5fqeA:
undetectable
2dttC-5fqeA:
undetectable		 2dttB-5fqeA:
12.72
2dttC-5fqeA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		4 ASP B 431
THR B 289
GLU B 335
GLU B 295
 None
 1.28A 2dttB-5hb4B:
undetectable
2dttC-5hb4B:
undetectable		 2dttB-5hb4B:
6.05
2dttC-5hb4B:
6.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hca CALRETICULIN,CALRETI
CULIN

(Entamoeba
histolytica) 		no annotation 4 ASP C  26
THR C  21
GLU C  20
GLU C  23
 None
 1.18A 2dttB-5hcaC:
undetectable
2dttC-5hcaC:
undetectable		 2dttB-5hcaC:
18.35
2dttC-5hcaC:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hmp UNCONVENTIONAL
MYOSIN-VC

(Homo sapiens) 		PF00063
(Myosin_head) 		4 ASP A 443
PHE A 442
THR A 209
GLU A 254
 None
 1.20A 2dttB-5hmpA:
undetectable
2dttC-5hmpA:
undetectable		 2dttB-5hmpA:
10.46
2dttC-5hmpA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jp6 PUTATIVE
POLYSACCHARIDE
DEACETYLASE

(Bdellovibrio
bacteriovorus) 		PF01522
(Polysacc_deac_1) 		4 ASP A 122
PHE A 121
THR A  91
GLU A  94
 None
 1.16A 2dttB-5jp6A:
undetectable
2dttC-5jp6A:
undetectable		 2dttB-5jp6A:
13.68
2dttC-5jp6A:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8d COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION

(Homo sapiens) 		PF00754
(F5_F8_type_C)
PF07731
(Cu-oxidase_2) 		4 ASP B1831
PHE B1830
THR B1964
GLU B1970
 None
 1.29A 2dttB-5k8dB:
undetectable
2dttC-5k8dB:
undetectable		 2dttB-5k8dB:
11.24
2dttC-5k8dB:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5knn ALANINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF01411
(tRNA-synt_2c) 		4 ASP A 359
PHE A 361
THR A  72
GLU A  99
 None
 1.18A 2dttB-5knnA:
undetectable
2dttC-5knnA:
undetectable		 2dttB-5knnA:
15.16
2dttC-5knnA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqa POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 4

(Homo sapiens) 		no annotation 4 ASP A 521
THR A 489
GLU A 439
GLU A 493
 None
 1.47A 2dttB-5nqaA:
undetectable
2dttC-5nqaA:
undetectable		 2dttB-5nqaA:
25.69
2dttC-5nqaA:
25.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqa POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 4

(Homo sapiens) 		no annotation 4 ASP A 521
THR A 489
GLU A 493
GLU A 439
 None
 1.43A 2dttB-5nqaA:
undetectable
2dttC-5nqaA:
undetectable		 2dttB-5nqaA:
25.69
2dttC-5nqaA:
25.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT) 		4 TYR T3388
ASP T3460
THR T3384
GLU T3469
 None
 1.40A 2dttB-5ojsT:
undetectable
2dttC-5ojsT:
undetectable		 2dttB-5ojsT:
2.79
2dttC-5ojsT:
2.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wee VENOM ALLERGEN LIKE
PROTEIN 4

(Heligmosomoides
polygyrus) 		no annotation 4 ASP A  25
PHE A  22
THR A 102
GLU A  99
 None
 1.19A 2dttB-5weeA:
undetectable
2dttC-5weeA:
undetectable		 2dttB-5weeA:
19.20
2dttC-5weeA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zqz TRIFUNCTIONAL ENZYME
SUBUNIT ALPHA,
MITOCHONDRIAL

(Homo sapiens) 		no annotation 4 ASP A 541
PHE A 545
THR A 547
GLU A 510
 None
 1.26A 2dttB-5zqzA:
undetectable
2dttC-5zqzA:
undetectable		 2dttB-5zqzA:
18.75
2dttC-5zqzA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cg0 V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1

(Mus musculus) 		no annotation 4 TYR A 725
ASP A 774
THR A 732
GLU A 736
 None
 1.45A 2dttB-6cg0A:
1.8
2dttC-6cg0A:
1.7		 2dttB-6cg0A:
18.49
2dttC-6cg0A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cp0 -

(-) 		no annotation 4 ASP A 172
PHE A 171
THR A  47
GLU A 443
 None
 1.43A 2dttB-6cp0A:
0.7
2dttC-6cp0A:
undetectable		 2dttB-6cp0A:
undetectable
2dttC-6cp0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5o RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza B
virus) 		no annotation 4 ASP B 210
THR B 213
GLU B 178
GLU B 216
 None
 1.45A 2dttB-6f5oB:
undetectable
2dttC-6f5oB:
undetectable		 2dttB-6f5oB:
17.54
2dttC-6f5oB:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhs INO80
RUVB-LIKE HELICASE

(Chaetomium
thermophilum) 		no annotation 4 PHE G1288
THR A 128
GLU A 127
GLU G1290
 None
 1.32A 2dttB-6fhsG:
undetectable
2dttC-6fhsG:
undetectable		 2dttB-6fhsG:
16.10
2dttC-6fhsG:
16.10