SIMILAR PATTERNS OF AMINO ACIDS FOR 2DRD_A_MIYA2001_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a4s BETAINE ALDEHYDE
DEHYDROGENASE

(Gadus morhua) 		PF00171
(Aldedh) 		5 GLN A 295
GLY A 109
GLU A 104
ASN A 107
ALA A  44
 None
 1.19A 2drdA-1a4sA:
0.0		 2drdA-1a4sA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)

(Geobacillus
stearothermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		5 GLY A 147
GLU A 145
ASN A 144
ILE A  74
ALA A 107
 None
 1.28A 2drdA-1brwA:
0.0		 2drdA-1brwA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3c PROTEIN
(ADENYLOSUCCINATE
LYASE)

(Thermotoga
maritima) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		5 GLY A 178
GLU A 207
ILE A 180
ALA A 198
VAL A  30
 None
 1.36A 2drdA-1c3cA:
0.1		 2drdA-1c3cA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1chd CHEB METHYLESTERASE

(Salmonella
enterica) 		PF01339
(CheB_methylest) 		5 GLY A 323
ASN A 320
ILE A 319
ALA A 303
VAL A 327
 None
 1.36A 2drdA-1chdA:
0.0		 2drdA-1chdA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ef7 CATHEPSIN X

(Homo sapiens) 		PF00112
(Peptidase_C1) 		5 GLY A  29
GLU A  72
ILE A  63
ALA A  33
VAL A  59
 None
 1.04A 2drdA-1ef7A:
0.0		 2drdA-1ef7A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8k ARSENITE OXIDASE

(Alcaligenes
faecalis) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		5 GLN A 690
PHE A 752
GLY A 753
GLU A 747
ALA A 468
 None
 1.26A 2drdA-1g8kA:
0.0		 2drdA-1g8kA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpe PROTEIN (GLUCOSE
OXIDASE)

(Penicillium
amagasakiense) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 GLN A  83
GLY A 294
ILE A 301
ALA A  30
VAL A 254
 FAD  A 600 (-3.7A)
FAD  A 600 ( 3.8A)
None
FAD  A 600 ( 4.8A)
FAD  A 600 (-4.0A)
 1.39A 2drdA-1gpeA:
2.2		 2drdA-1gpeA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nvm ACETALDEHYDE
DEHYDROGENASE
(ACYLATING)

(Pseudomonas sp.
CF600) 		PF01118
(Semialdhyde_dh)
PF09290
(AcetDehyd-dimer) 		5 PHE B  76
GLU B  88
ASN B  87
ILE B  10
ALA B   8
 None
None
NAD  B3501 ( 4.3A)
NAD  B3501 (-4.9A)
None
 1.38A 2drdA-1nvmB:
2.8		 2drdA-1nvmB:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9j ALDEHYDE
DEHYDROGENASE,
CYTOSOLIC 1

(Elephantulus
edwardii) 		PF00171
(Aldedh) 		5 GLN A 300
GLY A 111
GLU A 106
ASN A 109
ALA A  43
 None
 1.09A 2drdA-1o9jA:
0.0		 2drdA-1o9jA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogo DEXTRANASE

(Talaromyces
minioluteus) 		PF03718
(Glyco_hydro_49)
PF17433
(Glyco_hydro_49N) 		5 GLY X 377
GLU X 379
ASN X 348
ALA X 370
PHE X 373
 None
None
None
None
GLC  X1576 ( 4.1A)
 1.28A 2drdA-1ogoX:
undetectable		 2drdA-1ogoX:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qdl PROTEIN
(ANTHRANILATE
SYNTHASE
(TRPE-SUBUNIT))

(Sulfolobus
solfataricus) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		5 PHE A 329
GLU A 371
ILE A 374
ALA A 331
VAL A 334
 None
 1.28A 2drdA-1qdlA:
2.5		 2drdA-1qdlA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rin PEA LECTIN

(Pisum sativum) 		PF00139
(Lectin_legB) 		5 GLY A 157
GLU A 159
ILE A  71
ALA A  73
VAL A  79
 None
 1.14A 2drdA-1rinA:
undetectable		 2drdA-1rinA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rk2 RIBOKINASE

(Escherichia
coli) 		PF00294
(PfkB) 		5 GLY A  44
ASN A  14
ILE A  13
ALA A  62
VAL A  87
 None
RIB  A 311 (-4.1A)
None
None
None
 1.22A 2drdA-1rk2A:
undetectable		 2drdA-1rk2A:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sr8 COBALAMIN
BIOSYNTHESIS PROTEIN
(CBID)

(Archaeoglobus
fulgidus) 		PF01888
(CbiD) 		5 GLY A 155
GLU A 112
ILE A  56
ALA A  52
VAL A  53
 None
 1.34A 2drdA-1sr8A:
undetectable		 2drdA-1sr8A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tlh 10 KDA ANTI-SIGMA
FACTOR

(Escherichia
virus T4) 		PF09010
(AsiA) 		5 GLY A  76
GLU A  78
ILE A  19
ALA A  15
PHE A  21
 None
 1.36A 2drdA-1tlhA:
undetectable		 2drdA-1tlhA:
6.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uj0 SIGNAL TRANSDUCING
ADAPTOR MOLECULE
(SH3 DOMAIN AND ITAM
MOTIF) 2

(Mus musculus) 		PF00018
(SH3_1) 		5 GLY A 249
GLU A 243
ASN A 244
ALA A 215
PHE A 255
 None
 1.39A 2drdA-1uj0A:
undetectable		 2drdA-1uj0A:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqp 8-OXOGUANINE DNA
GLYCOSYLASE

(Pyrobaculum
aerophilum) 		PF09171
(AGOG) 		5 GLY A 236
ILE A 242
ALA A 227
VAL A 228
PHE A 245
 None
 1.16A 2drdA-1xqpA:
undetectable		 2drdA-1xqpA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b7y FAVIN BETA CHAIN

(Vicia faba) 		PF00139
(Lectin_legB) 		5 GLY A 158
GLU A 160
ILE A  72
ALA A  74
VAL A  80
 None
 1.15A 2drdA-2b7yA:
undetectable		 2drdA-2b7yA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fgy CARBOXYSOME SHELL
POLYPEPTIDE

(Halothiobacillus
neapolitanus) 		PF08936
(CsoSCA) 		5 PHE A 159
GLY A 158
ASN A 227
VAL A 168
PHE A 165
 None
 1.24A 2drdA-2fgyA:
undetectable		 2drdA-2fgyA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fm8 CELL INVASION
PROTEIN SIPA

(Salmonella
enterica) 		PF09052
(SipA) 		5 PHE C  67
GLY C  70
ILE C 128
ALA C  75
VAL C  79
 None
 1.34A 2drdA-2fm8C:
undetectable		 2drdA-2fm8C:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fm9 CELL INVASION
PROTEIN SIPA

(Salmonella
enterica) 		PF09052
(SipA) 		5 PHE A  67
GLY A  70
ILE A 128
ALA A  75
VAL A  79
 None
 1.37A 2drdA-2fm9A:
undetectable		 2drdA-2fm9A:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ha9 UPF0210 PROTEIN
SP0239

(Streptococcus
pneumoniae) 		PF05167
(DUF711) 		5 GLY A 155
ASN A 157
ILE A 149
ALA A 383
PHE A 185
 None
 1.32A 2drdA-2ha9A:
undetectable		 2drdA-2ha9A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hhg HYPOTHETICAL PROTEIN
RPA3614

(Rhodopseudomonas
palustris) 		PF00581
(Rhodanese) 		5 GLY A  58
ILE A  41
ALA A  36
VAL A  39
PHE A  88
 None
 1.39A 2drdA-2hhgA:
undetectable		 2drdA-2hhgA:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jb7 HYPOTHETICAL PROTEIN
PAE2307

(Pyrobaculum
aerophilum) 		PF04008
(Adenosine_kin) 		5 GLU A  69
ASN A  72
ILE A  75
ALA A  51
VAL A  61
 None
 1.36A 2drdA-2jb7A:
4.2		 2drdA-2jb7A:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0m TRANSCRIPTIONAL
REGULATOR, SORC
FAMILY

(Enterococcus
faecalis) 		PF04198
(Sugar-bind) 		5 GLU A 143
ASN A 144
ILE A 146
ALA A 147
VAL A 148
 None
 1.28A 2drdA-2o0mA:
undetectable		 2drdA-2o0mA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pr1 UNCHARACTERIZED
N-ACETYLTRANSFERASE
YLBP

(Bacillus
subtilis) 		PF00583
(Acetyltransf_1) 		5 GLY A  97
GLU A 102
ALA A  58
VAL A  57
PHE A  52
 COA  A 206 (-2.6A)
None
None
None
None
 1.12A 2drdA-2pr1A:
undetectable		 2drdA-2pr1A:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pr1 UNCHARACTERIZED
N-ACETYLTRANSFERASE
YLBP

(Bacillus
subtilis) 		PF00583
(Acetyltransf_1) 		5 GLY A  97
ILE A  50
ALA A  58
VAL A  57
PHE A  52
 COA  A 206 (-2.6A)
None
None
None
None
 1.13A 2drdA-2pr1A:
undetectable		 2drdA-2pr1A:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q50 GLYOXYLATE
REDUCTASE/HYDROXYPYR
UVATE REDUCTASE

(Homo sapiens) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 GLY A 162
GLU A 191
ILE A 158
ALA A 215
VAL A 213
 None
 1.39A 2drdA-2q50A:
undetectable		 2drdA-2q50A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6z UROPORPHYRINOGEN
DECARBOXYLASE

(Homo sapiens) 		PF01208
(URO-D) 		5 GLY A 351
GLU A 348
ILE A 317
ALA A 356
VAL A 321
 None
 1.31A 2drdA-2q6zA:
undetectable		 2drdA-2q6zA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vr5 GLYCOGEN OPERON
PROTEIN GLGX

(Sulfolobus
solfataricus) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		5 PHE A 637
GLU A 441
ASN A 444
VAL A 613
PHE A 600
 None
 1.36A 2drdA-2vr5A:
undetectable		 2drdA-2vr5A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wrz L-ARABINOSE-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF00532
(Peripla_BP_1) 		5 PHE A  61
GLY A   6
GLU A  34
ILE A  38
VAL A  40
 None
 1.06A 2drdA-2wrzA:
undetectable		 2drdA-2wrzA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xa2 TREHALOSE-SYNTHASE
TRET

(Pyrococcus
horikoshii) 		PF00534
(Glycos_transf_1) 		5 GLN A 236
GLU A 334
ILE A 350
ALA A 326
VAL A 347
 None
UPG  A1415 (-3.0A)
None
None
None
 1.28A 2drdA-2xa2A:
undetectable		 2drdA-2xa2A:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN

(Thermosynechococcus
vulcanus) 		PF00421
(PSII) 		5 GLN B 281
GLY B 427
ALA B 344
VAL B 345
PHE B 355
 None
 1.38A 2drdA-3a0hB:
undetectable		 2drdA-3a0hB:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bl9 SCAVENGER
MRNA-DECAPPING
ENZYME DCPS

(Homo sapiens) 		PF05652
(DcpS)
PF11969
(DcpS_C) 		5 GLY A 248
ASN A 243
ILE A 244
ALA A 220
VAL A 278
 None
 1.35A 2drdA-3bl9A:
undetectable		 2drdA-3bl9A:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c2u XYLOSIDASE/ARABINOSI
DASE

(Selenomonas
ruminantium) 		PF04616
(Glyco_hydro_43)
PF07081
(DUF1349) 		5 GLY A 113
GLU A 109
ILE A 111
ALA A  52
VAL A  51
 None
 1.41A 2drdA-3c2uA:
undetectable		 2drdA-3c2uA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cyv UROPORPHYRINOGEN
DECARBOXYLASE

(Shigella
flexneri) 		PF01208
(URO-D) 		5 GLY A 339
GLU A 336
ILE A 304
ALA A 344
VAL A 308
 None
 1.20A 2drdA-3cyvA:
undetectable		 2drdA-3cyvA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqx FIC DOMAIN
CONTAINING
TRANSCRIPTIONAL
REGULATOR

(Shewanella
oneidensis) 		PF02661
(Fic)
PF13784
(Fic_N) 		5 GLY A 208
GLU A  73
ASN A 204
ALA A 123
VAL A 120
 None
 1.39A 2drdA-3eqxA:
undetectable		 2drdA-3eqxA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcg L0028 (MITOCHONDRIA
ASSOCIATED PROTEIN)

(Escherichia
coli) 		PF03278
(IpaB_EvcA) 		5 GLN B  57
GLY B  52
ASN B 177
ILE B 173
VAL B 169
 None
 1.29A 2drdA-3gcgB:
undetectable		 2drdA-3gcgB:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwm HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE

(Mycolicibacterium
smegmatis) 		PF01648
(ACPS) 		5 GLY A   5
GLU A 129
ILE A 126
ALA A 125
VAL A 124
 GLY  A   5 ( 0.0A)
GLU  A 129 ( 0.6A)
ILE  A 126 ( 0.7A)
ALA  A 125 ( 0.0A)
VAL  A 124 ( 0.6A)
 1.41A 2drdA-3gwmA:
undetectable		 2drdA-3gwmA:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jca INTEGRASE

(Mouse mammary
tumor virus) 		PF00552
(IN_DBD_C)
PF00665
(rve)
PF02022
(Integrase_Zn) 		5 GLY A 227
ILE C 261
ALA C 243
VAL C 256
PHE C 260
 None
 1.22A 2drdA-3jcaA:
undetectable		 2drdA-3jcaA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lq1 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE-1-CARBOXYLA
TE SYNTHASE

(Listeria
monocytogenes) 		PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
PF16582
(TPP_enzyme_M_2) 		5 GLU A 267
ILE A 251
ALA A 253
VAL A 228
PHE A 294
 None
 1.30A 2drdA-3lq1A:
undetectable		 2drdA-3lq1A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o7q L-FUCOSE-PROTON
SYMPORTER

(Escherichia
coli) 		PF07690
(MFS_1) 		5 ASN A 139
ILE A 387
ALA A 263
VAL A 264
PHE A 386
 None
 1.00A 2drdA-3o7qA:
2.3		 2drdA-3o7qA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r4r HYPOTHETICAL
FIMBRIAL ASSEMBLY
PROTEIN

(Parabacteroides
distasonis) 		PF06321
(P_gingi_FimA) 		5 GLU A 311
ASN A 306
ILE A 284
ALA A 232
VAL A 233
 None
 1.36A 2drdA-3r4rA:
undetectable		 2drdA-3r4rA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s38 CYTOCHROME C OXIDASE
SUBUNIT 2

(Thermus
thermophilus) 		PF00116
(COX2)
PF09125
(COX2-transmemb) 		5 GLY B 115
ILE B 107
ALA B  85
VAL B  83
PHE B 105
 None
 1.10A 2drdA-3s38B:
undetectable		 2drdA-3s38B:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqt D-ALANINE--D-ALANINE
LIGASE

(Coxiella
burnetii) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		5 PHE A 291
GLU A 231
ILE A 317
ALA A 290
VAL A 294
 None
 1.28A 2drdA-3tqtA:
undetectable		 2drdA-3tqtA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wq8 BETA-GLUCOSIDASE

(Pyrococcus
furiosus) 		PF00232
(Glyco_hydro_1) 		5 PHE A 227
GLY A 215
ASN A 218
ILE A 217
ALA A 233
 None
 1.39A 2drdA-3wq8A:
undetectable		 2drdA-3wq8A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4az7 BETA-N-ACETYLHEXOSAM
INIDASE

(Streptococcus
pneumoniae) 		PF00728
(Glyco_hydro_20) 		5 GLN A 273
ASN A 267
ALA A 194
VAL A 223
PHE A 230
 None
 1.22A 2drdA-4az7A:
undetectable		 2drdA-4az7A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dut NUCLEOSIDE
DIPHOSPHATE KINASE

(Burkholderia
thailandensis) 		PF00334
(NDK) 		5 GLN A  22
PHE A 107
ILE A  10
ALA A 115
VAL A 116
 None
 1.40A 2drdA-4dutA:
4.0		 2drdA-4dutA:
8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ff5 GLYCOSYL HYDROLASE
25

(Streptococcus
pneumoniae) 		PF01183
(Glyco_hydro_25) 		5 GLY A  54
ASN A 224
ILE A  56
ALA A  96
VAL A  97
 None
 1.22A 2drdA-4ff5A:
undetectable		 2drdA-4ff5A:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hb4 EXPORTIN-1

(Saccharomyces
cerevisiae) 		PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C) 		5 PHE C 933
GLU C 926
ASN C 925
ILE C 971
VAL C 966
 None
 1.04A 2drdA-4hb4C:
undetectable		 2drdA-4hb4C:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i84 HEME/HEMOPEXIN-BINDI
NG PROTEIN

(Haemophilus
influenzae) 		PF05860
(Haemagg_act) 		5 PHE A 148
ASN A 139
ILE A 143
ALA A 145
VAL A  98
 None
 1.28A 2drdA-4i84A:
undetectable		 2drdA-4i84A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxk OXIDOREDUCTASE

(Rhodococcus
opacus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 PHE A 259
GLY A 263
ILE A 235
ALA A 240
VAL A 241
 None
 1.33A 2drdA-4jxkA:
undetectable		 2drdA-4jxkA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxn OCTAPRENYL-DIPHOSPHA
TE SYNTHASE

(Roseobacter
denitrificans) 		PF00348
(polyprenyl_synt) 		5 PHE A 184
GLY A 209
GLU A 207
ALA A 187
VAL A  82
 None
 1.37A 2drdA-4jxnA:
1.2		 2drdA-4jxnA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k9q BENZOYLFORMATE
DECARBOXYLASE

(Polynucleobacter
necessarius) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 GLN A 433
PHE A 432
GLY A 428
ASN A 456
VAL A 521
 None
None
TPP  A 602 (-3.4A)
MG  A 601 ( 2.7A)
None
 1.37A 2drdA-4k9qA:
undetectable		 2drdA-4k9qA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4krt AUTOLYTIC LYSOZYME

(Clostridium
phage phiSM101) 		PF01183
(Glyco_hydro_25)
PF08239
(SH3_3) 		5 GLU A  88
ASN A  87
ILE A  83
ALA A  79
VAL A 124
 None
 1.35A 2drdA-4krtA:
undetectable		 2drdA-4krtA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kru AUTOLYTIC LYSOZYME

(Clostridium
phage phiSM101) 		PF01183
(Glyco_hydro_25) 		5 GLU A  88
ASN A  87
ILE A  83
ALA A  79
VAL A 124
 None
 1.33A 2drdA-4kruA:
undetectable		 2drdA-4kruA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mh1 SORBOSE
DEHYDROGENASE

(Ketogulonicigenium
vulgare) 		PF13360
(PQQ_2) 		5 GLN A 487
GLU A  38
ASN A  39
ILE A  35
VAL A 517
 None
 1.28A 2drdA-4mh1A:
undetectable		 2drdA-4mh1A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4od5 4-HYDROXYBENZOATE
OCTAPRENYLTRANSFERAS
E

(Aeropyrum
pernix) 		PF01040
(UbiA) 		5 GLY A 173
ASN A 261
ILE A 242
ALA A 214
VAL A 215
 None
 1.31A 2drdA-4od5A:
undetectable		 2drdA-4od5A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ou2 2-AMINOMUCONATE
6-SEMIALDEHYDE
DEHYDROGENASE

(Pseudomonas
fluorescens) 		PF00171
(Aldedh) 		5 GLY A  90
ILE A  87
ALA A 211
VAL A 213
PHE A 218
 None
 1.33A 2drdA-4ou2A:
undetectable		 2drdA-4ou2A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p22 UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 1

(Homo sapiens) 		PF00899
(ThiF)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		5 PHE A 195
GLY A 196
ASN A 398
ILE A 397
ALA A 428
 None
 1.38A 2drdA-4p22A:
3.6		 2drdA-4p22A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p69 ISOCITRATE
DEHYDROGENASE
KINASE/PHOSPHATASE

(Escherichia
coli) 		PF06315
(AceK) 		5 GLU A 296
ILE A 287
ALA A 261
VAL A 259
PHE A 257
 None
 1.39A 2drdA-4p69A:
undetectable		 2drdA-4p69A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pcg VP1

(Human
polyomavirus 6) 		PF00718
(Polyoma_coat) 		5 GLY A 140
ILE A 243
ALA A 100
VAL A 282
PHE A 280
 None
 1.03A 2drdA-4pcgA:
undetectable		 2drdA-4pcgA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pka PATATIN-17

(Solanum
cardiophyllum) 		PF01734
(Patatin) 		5 GLY X 346
GLU X 321
ILE X  42
ALA X  45
VAL X 103
 None
 1.36A 2drdA-4pkaX:
undetectable		 2drdA-4pkaX:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdv M7GPPPX
DIPHOSPHATASE

(Homo sapiens) 		PF05652
(DcpS)
PF11969
(DcpS_C) 		5 GLY A 248
ASN A 243
ILE A 244
ALA A 220
VAL A 278
 None
 1.39A 2drdA-4qdvA:
undetectable		 2drdA-4qdvA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rkz PUTATIVE
UNCHARACTERIZED
PROTEIN TA1305

(Thermoplasma
acidophilum) 		no annotation 5 PHE A 228
GLY A 226
ILE A 215
ALA A 231
VAL A  16
 None
 1.05A 2drdA-4rkzA:
3.4		 2drdA-4rkzA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rr5 MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Synechocystis
sp. PCC 6803) 		PF00698
(Acyl_transf_1) 		5 GLY A 161
GLU A 145
ILE A 159
ALA A 126
VAL A 158
 None
 1.36A 2drdA-4rr5A:
2.0		 2drdA-4rr5A:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN

(Haemophilus
influenzae) 		PF05860
(Haemagg_act) 		5 PHE A 150
ASN A 141
ILE A 145
ALA A 147
VAL A 100
 None
 1.30A 2drdA-4rt6A:
undetectable		 2drdA-4rt6A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2x ENDO-BETA-1,4-GLUCAN
ASE (CELLULASE B)

(Bacillus
halodurans) 		PF00150
(Cellulase)
PF03442
(CBM_X2) 		5 GLY A 301
GLU A 506
ASN A 259
ILE A 309
PHE A 266
 None
GOL  A1568 (-2.9A)
GOL  A1569 (-3.9A)
None
None
 1.22A 2drdA-4v2xA:
undetectable		 2drdA-4v2xA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yly PEPTIDYL-TRNA
HYDROLASE

(Staphylococcus
aureus) 		PF01195
(Pept_tRNA_hydro) 		5 GLY A  22
GLU A  60
ILE A 162
ALA A 165
VAL A 161
 None
 1.40A 2drdA-4ylyA:
undetectable		 2drdA-4ylyA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysh GLYCINE OXIDASE

(Geobacillus
kaustophilus) 		PF01266
(DAO) 		5 GLY A  12
GLU A 176
ILE A   9
ALA A 207
VAL A 205
 FAD  A 401 ( 4.8A)
None
None
None
None
 1.37A 2drdA-4yshA:
undetectable		 2drdA-4yshA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b4s CHITOSANASE

(Mitsuaria
chitosanitabida) 		PF13647
(Glyco_hydro_80) 		5 GLN A 204
GLY A 200
ILE A 269
ALA A  32
VAL A 282
 None
 1.27A 2drdA-5b4sA:
undetectable		 2drdA-5b4sA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5x LIMITING
CO2-INDUCIBLE
PROTEIN LCIC

(Chlamydomonas
reinhardtii) 		no annotation 5 GLY A 145
GLU A 234
ILE A 269
ALA A 265
PHE A 177
 ZN  A 500 ( 4.6A)
None
None
None
None
 1.12A 2drdA-5b5xA:
undetectable		 2drdA-5b5xA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2v HYDRAZINE SYNTHASE
BETA SUBUNIT

(Candidatus
Kuenenia
stuttgartiensis) 		PF02239
(Cytochrom_D1) 		5 GLN B  66
PHE B  50
GLU B  84
ALA B 371
PHE B 374
 None
 1.15A 2drdA-5c2vB:
undetectable		 2drdA-5c2vB:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwc DESIGNED HELICAL
REPEAT PROTEIN

(synthetic
construct) 		no annotation 5 PHE A  88
GLU A  65
ILE A 113
ALA A  87
PHE A 138
 None
 1.10A 2drdA-5cwcA:
2.9		 2drdA-5cwcA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e0c CELLULASE

(Bacillus sp.
BG-CS10) 		PF00150
(Cellulase)
PF03442
(CBM_X2) 		5 GLY A 276
GLU A 481
ASN A 234
ILE A 284
PHE A 241
 None
 1.28A 2drdA-5e0cA:
undetectable		 2drdA-5e0cA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5en4 17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14

(Homo sapiens) 		PF13561
(adh_short_C2) 		5 GLY A  45
GLU A  43
ILE A  38
ALA A  23
VAL A  26
 None
 1.28A 2drdA-5en4A:
undetectable		 2drdA-5en4A:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fad RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE

(Sulfolobus
islandicus) 		PF13847
(Methyltransf_31) 		5 GLY A  40
GLU A  59
ILE A  72
ALA A  81
VAL A  77
 None
SAH  A 201 (-2.9A)
None
None
None
 1.40A 2drdA-5fadA:
undetectable		 2drdA-5fadA:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fv4 CARBOXYLIC ESTER
HYDROLASE

(Sus scrofa) 		PF00135
(COesterase) 		5 GLN A 177
GLY A 207
GLU A 203
ALA A 233
VAL A 239
 None
 1.26A 2drdA-5fv4A:
undetectable		 2drdA-5fv4A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gwt 4-HYDROXYISOLECUINE
DEHYDROGENASE

(Bacillus
thuringiensis) 		no annotation 5 GLY A  11
ILE A  21
ALA A  33
VAL A  31
PHE A  24
 NAD  A 301 (-3.4A)
None
None
None
None
 1.22A 2drdA-5gwtA:
undetectable		 2drdA-5gwtA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6v TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11

(Homo sapiens) 		PF00017
(SH2)
PF00102
(Y_phosphatase) 		5 GLN A 510
ILE A 470
ALA A 329
VAL A 457
PHE A 469
 None
 1.24A 2drdA-5i6vA:
undetectable		 2drdA-5i6vA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihr PROBABLE
BETA-GALACTOSIDASE A

(Aspergillus
niger) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		5 GLY A 301
ILE A 344
ALA A 367
VAL A 368
PHE A 345
 None
 1.31A 2drdA-5ihrA:
undetectable		 2drdA-5ihrA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikg DYE-DECOLORIZING
PEROXIDASE

(Auricularia
auricula-judae) 		PF04261
(Dyp_perox) 		5 GLN A 218
PHE A 216
GLY A 431
ILE A 114
VAL A 117
 None
 1.16A 2drdA-5ikgA:
undetectable		 2drdA-5ikgA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikj CRYPTIC LOCI
REGULATOR 2

(Schizosaccharomyces
pombe) 		PF10383
(Clr2)
PF16761
(Clr2_transil) 		5 PHE A 372
GLY A 374
ILE A 319
ALA A 510
VAL A 511
 None
 1.08A 2drdA-5ikjA:
undetectable		 2drdA-5ikjA:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Saccharomyces
cerevisiae) 		PF00562
(RNA_pol_Rpb2_6)
PF00623
(RNA_pol_Rpb1_2)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		5 PHE A 662
GLY A 661
ILE B1085
ALA B 828
PHE B1069
 None
 1.18A 2drdA-5ip9A:
3.6		 2drdA-5ip9A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jb3 30S RIBOSOMAL
PROTEIN S3

(Pyrococcus
abyssi) 		PF00189
(Ribosomal_S3_C)
PF07650
(KH_2) 		5 GLN Z 148
GLY Z 127
ILE Z 182
ALA Z 181
VAL Z 180
 None
 1.39A 2drdA-5jb3Z:
4.3		 2drdA-5jb3Z:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jyd SHORT CHAIN
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF13561
(adh_short_C2) 		5 GLY A  99
GLU A 104
ALA A  97
VAL A  96
PHE A  89
 None
NAD  A 901 ( 2.6A)
None
None
None
 1.22A 2drdA-5jydA:
undetectable		 2drdA-5jydA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k5w LIMITING
CO2-INDUCIBLE
PROTEIN LCIB

(Chlamydomonas
reinhardtii) 		no annotation 5 GLY A 146
GLU A 235
ILE A 270
ALA A 266
PHE A 178
 ZN  A 500 ( 4.5A)
None
None
None
None
 1.07A 2drdA-5k5wA:
undetectable		 2drdA-5k5wA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcn UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF12146
(Hydrolase_4) 		5 PHE A 148
GLY A 151
GLU A 121
ALA A 170
VAL A 169
 None
 1.15A 2drdA-5lcnA:
undetectable		 2drdA-5lcnA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tz6 CURJ

(Moorea
producens) 		PF14765
(PS-DH) 		5 PHE A1119
GLY A1116
ILE A 979
ALA A 976
VAL A 984
 None
 1.35A 2drdA-5tz6A:
undetectable		 2drdA-5tz6A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7n CYTOCHROME C OXIDASE
SUBUNIT 2

(Thermus
thermophilus) 		no annotation 5 GLY A 115
ILE A 107
ALA A  85
VAL A  83
PHE A 105
 None
 1.13A 2drdA-5u7nA:
undetectable		 2drdA-5u7nA:
5.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5upy INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Listeria
monocytogenes) 		PF00478
(IMPDH) 		5 GLY A 357
GLU A 456
ILE A 338
ALA A 340
VAL A 300
 None
 1.12A 2drdA-5upyA:
undetectable		 2drdA-5upyA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vni PROTEIN TRANSPORT
PROTEIN SEC23A

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 GLY A 418
GLU A 437
ASN A 436
ALA A  39
VAL A  38
 None
 1.34A 2drdA-5vniA:
3.0		 2drdA-5vniA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2g CRISPR-ASSOCIATED
ENDONUCLEASE CAS9

(Campylobacter
jejuni) 		no annotation 5 GLY A  10
GLU A 479
ILE A 643
ALA A 455
VAL A 452
 None
 1.34A 2drdA-5x2gA:
3.0		 2drdA-5x2gA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7k LIPASE B

(Serratia
marcescens) 		no annotation 5 GLU A 424
ASN A 425
ILE A 476
ALA A 441
VAL A 446
 None
 1.40A 2drdA-5x7kA:
undetectable		 2drdA-5x7kA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xn8 GLYCEROL
DEHYDROGENASE

(unidentified) 		PF00465
(Fe-ADH) 		5 GLN A 361
GLY A 359
GLU A 301
ILE A 293
VAL A 284
 None
 1.29A 2drdA-5xn8A:
undetectable		 2drdA-5xn8A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aun PLA2G6, IPLA2BETA

(Cricetulus
griseus) 		no annotation 5 PHE A 372
GLY A 373
GLU A 375
ILE A 444
ALA A 481
 None
 1.30A 2drdA-6aunA:
undetectable		 2drdA-6aunA:
6.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5i RETINAL
DEHYDROGENASE 2

(Homo sapiens) 		no annotation 5 GLN A 318
GLY A 129
GLU A 124
ASN A 127
ALA A  61
 None
 1.10A 2drdA-6b5iA:
undetectable		 2drdA-6b5iA:
6.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqy TYROSINE--TRNA
LIGASE

(Acinetobacter
baumannii) 		no annotation 5 GLU A 133
ASN A 131
ILE A  81
ALA A 110
PHE A  49
 None
EDO  A 502 (-3.4A)
None
None
None
 1.37A 2drdA-6bqyA:
undetectable		 2drdA-6bqyA:
6.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cj0 TREHALOSE
PHOSPHATASE

(Pseudomonas
aeruginosa) 		no annotation 6 GLY A  89
GLU A 142
ILE A  84
ALA A 198
VAL A 199
PHE A 227
 None
 1.41A 2drdA-6cj0A:
4.2		 2drdA-6cj0A:
5.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fsa -

(-) 		no annotation 5 GLN A 315
GLY A 360
GLU A 380
ILE A 356
ALA A 428
 None
 1.38A 2drdA-6fsaA:
2.1		 2drdA-6fsaA:
undetectable