SIMILAR PATTERNS OF AMINO ACIDS FOR 2DQY_B_CHDB2
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1d8c | MALATE SYNTHASE G (Escherichiacoli) |
PF01274(Malate_synthase) | 3 | TRP A 481LYS A 78PRO A 480 | None | 1.42A | 2dqyB-1d8cA:1.3 | 2dqyB-1d8cA:21.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1euz | GLUTAMATEDEHYDROGENASE (Thermococcusprofundus) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 3 | TRP A 355LYS A 177PRO A 137 | None | 1.48A | 2dqyB-1euzA:4.2 | 2dqyB-1euzA:20.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gju | MALTODEXTRINGLYCOSYLTRANSFERASE (Thermotogamaritima) |
PF00128(Alpha-amylase)PF09083(DUF1923) | 3 | TRP A 315LYS A 151PRO A 313 | None | 1.24A | 2dqyB-1gjuA:0.7 | 2dqyB-1gjuA:22.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hzv | NITRITE REDUCTASE (Pseudomonasaeruginosa) |
PF02239(Cytochrom_D1)PF13442(Cytochrome_CBB3) | 3 | TRP A 246LYS A 219PRO A 117 | None | 1.22A | 2dqyB-1hzvA:undetectable | 2dqyB-1hzvA:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1izo | CYTOCHROME P450152A1 (Bacillussubtilis) |
PF00067(p450) | 3 | TRP A 328LYS A 26PRO A 331 | None | 1.18A | 2dqyB-1izoA:undetectable | 2dqyB-1izoA:22.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k32 | TRICORN PROTEASE (Thermoplasmaacidophilum) |
PF03572(Peptidase_S41)PF07676(PD40)PF14684(Tricorn_C1)PF14685(Tricorn_PDZ) | 3 | TRP A 863LYS A 780PRO A 155 | None | 1.45A | 2dqyB-1k32A:2.1 | 2dqyB-1k32A:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o20 | GAMMA-GLUTAMYLPHOSPHATE REDUCTASE (Thermotogamaritima) |
PF00171(Aldedh) | 3 | TRP A 15LYS A 26PRO A 113 | None | 1.41A | 2dqyB-1o20A:undetectable | 2dqyB-1o20A:22.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ogy | PERIPLASMIC NITRATEREDUCTASE (Rhodobactersphaeroides) |
PF00384(Molybdopterin)PF01568(Molydop_binding)PF04879(Molybdop_Fe4S4) | 3 | TRP A 549LYS A 109PRO A 550 | None | 1.35A | 2dqyB-1ogyA:0.0 | 2dqyB-1ogyA:21.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q87 | 39 KDA INITIATORBINDING PROTEIN (Trichomonasvaginalis) |
PF11422(IBP39) | 3 | TRP A 275LYS A 226PRO A 259 | None | 1.29A | 2dqyB-1q87A:1.7 | 2dqyB-1q87A:17.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wp9 | ATP-DEPENDENT RNAHELICASE, PUTATIVE (Pyrococcusfuriosus) |
PF00270(DEAD)PF00271(Helicase_C) | 3 | TRP A 206LYS A 344PRO A 446 | None | 1.36A | 2dqyB-1wp9A:undetectable | 2dqyB-1wp9A:21.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g29 | NITRATE TRANSPORTPROTEIN NRTA (Synechocystissp.) |
PF13379(NMT1_2) | 3 | TRP A 243LYS A 269PRO A 222 | NoneNO3 A 700 (-2.8A)NO3 A 700 (-3.7A) | 1.46A | 2dqyB-2g29A:undetectable | 2dqyB-2g29A:20.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gt1 | LIPOPOLYSACCHARIDEHEPTOSYLTRANSFERASE-1 (Escherichiacoli) |
PF01075(Glyco_transf_9) | 3 | TRP A 116LYS A 136PRO A 122 | None | 1.45A | 2dqyB-2gt1A:1.7 | 2dqyB-2gt1A:23.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pgg | RNA-DIRECTED RNAPOLYMERASE (Infectiousbursal diseasevirus) |
PF04197(Birna_RdRp) | 3 | TRP A 504LYS A 523PRO A 510 | None | 1.28A | 2dqyB-2pggA:2.6 | 2dqyB-2pggA:22.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r3a | HISTONE-LYSINEN-METHYLTRANSFERASESUV39H2 (Homo sapiens) |
PF00856(SET)PF05033(Pre-SET) | 3 | TRP A 152LYS A 189PRO A 55 | NoneSAM A 304 (-3.9A)None | 1.08A | 2dqyB-2r3aA:undetectable | 2dqyB-2r3aA:22.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w7y | PROBABLE SUGAR ABCTRANSPORTER,SUGAR-BINDINGPROTEIN (Streptococcuspneumoniae) |
PF13416(SBP_bac_8) | 3 | TRP A 53LYS A 287PRO A 54 | None | 1.37A | 2dqyB-2w7yA:undetectable | 2dqyB-2w7yA:20.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ciy | TOLL-LIKE RECEPTOR 3 (Mus musculus) |
PF00560(LRR_1)PF13855(LRR_8) | 3 | TRP A 546LYS A 550PRO A 578 | None | 1.09A | 2dqyB-3ciyA:undetectable | 2dqyB-3ciyA:22.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k8z | NAD-SPECIFICGLUTAMATEDEHYDROGENASE (Bacillussubtilis) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 3 | TRP A 361LYS A 185PRO A 147 | None | 1.44A | 2dqyB-3k8zA:4.5 | 2dqyB-3k8zA:20.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k92 | NAD-SPECIFICGLUTAMATEDEHYDROGENASE (Bacillussubtilis) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 3 | TRP A 362LYS A 186PRO A 148 | None | 1.42A | 2dqyB-3k92A:4.7 | 2dqyB-3k92A:20.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ndy | ENDOGLUCANASE D (Clostridiumcellulovorans) |
PF00150(Cellulase) | 3 | TRP A 244LYS A 281PRO A 231 | None | 1.36A | 2dqyB-3ndyA:0.8 | 2dqyB-3ndyA:19.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ugg | SUCROSE:(SUCROSE/FRUCTAN)6-FRUCTOSYLTRANSFERASE (Pachysandraterminalis) |
PF00251(Glyco_hydro_32N)PF08244(Glyco_hydro_32C) | 3 | TRP A 302LYS A 240PRO A 34 | None | 1.49A | 2dqyB-3uggA:undetectable | 2dqyB-3uggA:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b3k | BETA-GLUCOSIDASE (Streptococcuspyogenes) |
PF00232(Glyco_hydro_1) | 3 | TRP A 247LYS A 302PRO A 319 | None | 1.46A | 2dqyB-4b3kA:1.8 | 2dqyB-4b3kA:22.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bqn | CAPSULARPOLYSACCHARIDEBIOSYNTHESIS PROTEIN (Burkholderiapseudomallei) |
no annotation | 3 | TRP A 279LYS A 267PRO A 117 | None | 1.29A | 2dqyB-4bqnA:undetectable | 2dqyB-4bqnA:20.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4im4 | ENDOGLUCANASE E (Ruminiclostridiumthermocellum) |
PF00150(Cellulase) | 3 | TRP A 285LYS A 322PRO A 272 | None | 1.45A | 2dqyB-4im4A:0.8 | 2dqyB-4im4A:20.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kh9 | HYPOTHETICAL PROTEIN (Legionellapneumophila) |
PF16024(DUF4785) | 3 | TRP A 256LYS A 376PRO A 222 | None | 1.10A | 2dqyB-4kh9A:undetectable | 2dqyB-4kh9A:20.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e59 | FRNE PROTEIN (Deinococcusradiodurans) |
PF01323(DSBA) | 3 | TRP A 24LYS A 73PRO A 23 | None | 1.29A | 2dqyB-5e59A:undetectable | 2dqyB-5e59A:19.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f8p | ALPHA-KETOGLUTARATE-DEPENDENTDIOXYGENASE FTO (Homo sapiens) |
PF12933(FTO_NTD)PF12934(FTO_CTD) | 3 | TRP A 395LYS A 128PRO A 117 | None | 1.39A | 2dqyB-5f8pA:undetectable | 2dqyB-5f8pA:20.53 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5fv4 | CARBOXYLIC ESTERHYDROLASE (Sus scrofa) |
PF00135(COesterase) | 3 | TRP A 339LYS A 395PRO A 442 | None | 0.76A | 2dqyB-5fv4A:66.5 | 2dqyB-5fv4A:79.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gzy | (R)-2-HALOACIDDEHALOGENASE (Pseudomonasputida) |
PF10778(DehI) | 3 | TRP A 283LYS A 142PRO A 15 | None | 1.26A | 2dqyB-5gzyA:undetectable | 2dqyB-5gzyA:20.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jwy | PHOSPHATIDYLGLYCEROPHOSPHATASE B (Escherichiacoli) |
PF01569(PAP2) | 3 | TRP A 52LYS A 153PRO A 51 | None | 1.42A | 2dqyB-5jwyA:undetectable | 2dqyB-5jwyA:18.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5med | ARACHIDONATE15-LIPOXYGENASE (Cyanothece sp.PCC 8801) |
PF00305(Lipoxygenase) | 3 | TRP A 198LYS A 147PRO A 200 | None | 1.30A | 2dqyB-5medA:0.4 | 2dqyB-5medA:22.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mjs | TUBULIN BETA CHAINMICROTUBULEINTEGRITY PROTEINMAL3 (Schizosaccharomycespombe;Schizosaccharomycespombe) |
no annotationno annotation | 3 | TRP D 62LYS A 174PRO D 80 | None | 0.89A | 2dqyB-5mjsD:undetectable | 2dqyB-5mjsD:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u7g | CREB-BINDING PROTEIN (Mus musculus) |
PF00439(Bromodomain)PF00569(ZZ)PF06001(DUF902)PF08214(HAT_KAT11) | 3 | TRP A1152LYS A1083PRO A1151 | None | 1.41A | 2dqyB-5u7gA:undetectable | 2dqyB-5u7gA:21.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uqc | DIHYDROPYRIMIDINASE-RELATED PROTEIN 2 (Mus musculus) |
PF01979(Amidohydro_1) | 3 | TRP A 412LYS A 23PRO A 414 | None | 1.38A | 2dqyB-5uqcA:undetectable | 2dqyB-5uqcA:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y3r | DNA-DEPENDENTPROTEIN KINASECATALYTIC SUBUNIT (Homo sapiens) |
PF00454(PI3_PI4_kinase)PF02259(FAT)PF02260(FATC)PF08163(NUC194) | 3 | TRP C4013LYS C4019PRO C4009 | None | 1.45A | 2dqyB-5y3rC:undetectable | 2dqyB-5y3rC:8.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6eoj | POLYADENYLATIONFACTOR SUBUNIT2,POLYADENYLATIONFACTOR SUBUNIT 2 (Saccharomycescerevisiae) |
no annotation | 3 | TRP D 312LYS D 142PRO D 271 | None | 1.21A | 2dqyB-6eojD:undetectable | 2dqyB-6eojD:21.75 |