SIMILAR PATTERNS OF AMINO ACIDS FOR 2DPZ_A_TYLA2001_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1a2a PHOSPHOLIPASE A2

(Gloydius halys) 		PF00068
(Phospholip_A2_1) 		5 LEU A   2
ALA A  18
HIS A  48
ASP A  49
TYR A  52
 None
 0.52A 2dpzA-1a2aA:
22.3		 2dpzA-1a2aA:
62.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ae7 PHOSPHOLIPASE A2

(Notechis
scutatus) 		PF00068
(Phospholip_A2_1) 		4 LEU A   2
HIS A  48
ASP A  49
TYR A  52
 None
 0.66A 2dpzA-1ae7A:
16.4		 2dpzA-1ae7A:
36.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1aok VIPOXIN COMPLEX

(Vipera
ammodytes) 		PF00068
(Phospholip_A2_1) 		4 LEU B   2
HIS B  48
ASP B  49
TYR B  52
 None
ACT  B 134 (-3.6A)
ACT  B 134 ( 4.9A)
None
 0.32A 2dpzA-1aokB:
21.1		 2dpzA-1aokB:
56.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bpq PHOSPHOLIPASE A2

(Bos taurus) 		PF00068
(Phospholip_A2_1) 		4 LEU A   2
HIS A  48
ASP A  49
TYR A  52
 None
None
CA  A 124 (-2.1A)
None
 0.54A 2dpzA-1bpqA:
18.1		 2dpzA-1bpqA:
39.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dpy PHOSPHOLIPASE A2

(Bungarus
caeruleus) 		PF00068
(Phospholip_A2_1) 		4 LEU A   2
HIS A  48
ASP A  49
TYR A  52
 None
None
NA  A 150 (-2.5A)
None
 0.48A 2dpzA-1dpyA:
17.5		 2dpzA-1dpyA:
39.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1g0z PHOSPHOLIPASE A2

(Bungarus
caeruleus) 		PF00068
(Phospholip_A2_1) 		4 LEU A   2
HIS A  48
ASP A  49
TYR A  52
 None
 0.48A 2dpzA-1g0zA:
17.3		 2dpzA-1g0zA:
39.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gdh D-GLYCERATE
DEHYDROGENASE

(Hyphomicrobium
methylovorum) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 LEU A 320
ALA A  97
HIS A  81
ASP A  80
 None
 1.12A 2dpzA-1gdhA:
undetectable		 2dpzA-1gdhA:
16.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gmz PHOSPHOLIPASE A2

(Bothrops
pirajai) 		PF00068
(Phospholip_A2_1) 		4 LEU A   2
HIS A  47
ASP A  48
TYR A  51
 None
 0.34A 2dpzA-1gmzA:
20.7		 2dpzA-1gmzA:
64.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gp7 PHOSPHOLIPASE A2

(Ophiophagus
hannah) 		PF00068
(Phospholip_A2_1) 		4 LEU A   2
HIS A  48
ASP A  49
TYR A  52
 None
None
CA  A1125 (-2.4A)
None
 0.58A 2dpzA-1gp7A:
17.0		 2dpzA-1gp7A:
35.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqj ALPHA-D-GLUCURONIDAS
E

(Cellvibrio
japonicus) 		PF03648
(Glyco_hydro_67N)
PF07477
(Glyco_hydro_67C)
PF07488
(Glyco_hydro_67M) 		4 LEU A 538
ALA A 545
HIS A 528
ASP A 527
 None
None
XYP  A1719 (-4.4A)
None
 1.09A 2dpzA-1gqjA:
undetectable		 2dpzA-1gqjA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hww ALPHA-MANNOSIDASE II

(Drosophila
melanogaster) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		4 LEU A 508
ALA A 444
HIS A 950
ASP A 949
 None
 1.35A 2dpzA-1hwwA:
undetectable		 2dpzA-1hwwA:
7.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ijl PHOSPHOLIPASE A2

(Deinagkistrodon
acutus) 		PF00068
(Phospholip_A2_1) 		4 LEU A   2
HIS A  47
ASP A  48
TYR A  51
 None
None
CA  A 203 (-2.6A)
None
 0.58A 2dpzA-1ijlA:
20.9		 2dpzA-1ijlA:
52.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jne IMAGINAL DISC GROWTH
FACTOR-2

(Drosophila
melanogaster) 		PF00704
(Glyco_hydro_18) 		4 LEU A 315
ALA A 277
HIS A  87
LYS A 312
 None
 1.11A 2dpzA-1jneA:
undetectable		 2dpzA-1jneA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js1 TRANSCARBAMYLASE

(Bacteroides
fragilis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 LEU X 155
ALA X  16
ASP X 196
TYR X 197
 None
 1.17A 2dpzA-1js1X:
undetectable		 2dpzA-1js1X:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lsh LIPOVITELLIN (LV-1N,
LV-1C)

(Ichthyomyzon
unicuspis) 		PF01347
(Vitellogenin_N)
PF09172
(DUF1943) 		4 LEU A 546
ALA A 514
ASP A 504
LYS A 543
 None
 1.21A 2dpzA-1lshA:
undetectable		 2dpzA-1lshA:
7.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1m8r PHOSPHOLIPASE A2

(Gloydius halys) 		PF00068
(Phospholip_A2_1) 		4 LEU A   2
HIS A  48
ASP A  49
TYR A  52
 None
None
CD  A1001 (-2.4A)
None
 0.59A 2dpzA-1m8rA:
20.9		 2dpzA-1m8rA:
54.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1m8t PHOSPHOLIPASE A2

(Ophiophagus
hannah) 		PF00068
(Phospholip_A2_1) 		4 LEU A   2
HIS A  48
ASP A  49
TYR A  52
 HEZ  A1002 (-4.0A)
None
CA  A1001 (-2.1A)
None
 0.52A 2dpzA-1m8tA:
18.3		 2dpzA-1m8tA:
40.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mcw IMMUNOGLOBULIN WEIR
(LIGHT CHAIN)

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU W 182
ALA W 134
HIS W 192
ASP W 155
 None
 1.22A 2dpzA-1mcwW:
undetectable		 2dpzA-1mcwW:
20.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mh2 PHOSPHOLIPASE A2

(Naja
sagittifera) 		PF00068
(Phospholip_A2_1) 		4 ALA A  23
HIS A  48
TYR A  52
LYS A  64
 None
ACY  A 302 (-3.4A)
None
ACY  A 302 (-2.7A)
 1.18A 2dpzA-1mh2A:
18.4		 2dpzA-1mh2A:
36.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mh2 PHOSPHOLIPASE A2

(Naja
sagittifera) 		PF00068
(Phospholip_A2_1) 		4 HIS A  48
ASP A  49
TYR A  52
LYS A  64
 ACY  A 302 (-3.4A)
ACY  A 302 (-3.4A)
None
ACY  A 302 (-2.7A)
 0.66A 2dpzA-1mh2A:
18.4		 2dpzA-1mh2A:
36.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mh8 PHOSPHOLIPASE A2

(Naja
sagittifera) 		PF00068
(Phospholip_A2_1) 		4 ALA A  23
HIS A  48
TYR A  52
LYS A  64
 None
 0.88A 2dpzA-1mh8A:
18.9		 2dpzA-1mh8A:
38.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mh8 PHOSPHOLIPASE A2

(Naja
sagittifera) 		PF00068
(Phospholip_A2_1) 		4 HIS A  48
ASP A  49
TYR A  52
LYS A  64
 None
 0.41A 2dpzA-1mh8A:
18.9		 2dpzA-1mh8A:
38.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ozy PHOSPHOLIPASE A2

(Micropechis
ikaheca) 		PF00068
(Phospholip_A2_1) 		4 LEU A   2
HIS A  48
ASP A  49
TYR A  52
 None
 0.52A 2dpzA-1ozyA:
15.9		 2dpzA-1ozyA:
37.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1p7o PHOSPHOLIPASE A2

(Micropechis
ikaheca) 		PF00068
(Phospholip_A2_1) 		4 LEU A   2
HIS A  48
ASP A  49
TYR A  52
 None
 0.43A 2dpzA-1p7oA:
18.3		 2dpzA-1p7oA:
38.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1po8 PHOSPHOLIPASE A2

(Bungarus
caeruleus) 		PF00068
(Phospholip_A2_1) 		4 LEU A   2
HIS A  48
ASP A  49
TYR A  52
 None
SHV  A 122 (-4.1A)
NA  A 121 (-2.4A)
None
 0.41A 2dpzA-1po8A:
17.5		 2dpzA-1po8A:
38.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pp2 CALCIUM-FREE
PHOSPHOLIPASE A2

(Crotalus atrox) 		no annotation 4 LEU R   2
HIS R  48
ASP R  49
TYR R  52
 None
 0.71A 2dpzA-1pp2R:
21.3		 2dpzA-1pp2R:
54.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pwo PHOSPHOLIPASE A2

(Micropechis
ikaheca) 		PF00068
(Phospholip_A2_1) 		4 LEU A   2
HIS A  48
ASP A  49
TYR A  52
 None
 0.74A 2dpzA-1pwoA:
17.9		 2dpzA-1pwoA:
36.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q6v PHOSPHOLIPASE A2
VRV-PL-VIIIA

(Daboia russelii) 		PF00068
(Phospholip_A2_1) 		5 LEU A   2
ALA A  18
HIS A  48
TYR A  52
LYS A  69
 None
 0.73A 2dpzA-1q6vA:
25.7		 2dpzA-1q6vA:
95.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qle CYTOCHROME C OXIDASE
POLYPEPTIDE III

(Paracoccus
denitrificans) 		PF00510
(COX3) 		4 LEU C 227
ALA C 158
HIS C 255
ASP C 258
 None
 1.35A 2dpzA-1qleC:
undetectable		 2dpzA-1qleC:
15.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1s8h PHOSPHOLIPASE A2
HOMOLOG

(Agkistrodon
contortrix) 		PF00068
(Phospholip_A2_1) 		4 LEU A   2
ALA A  18
HIS A  48
TYR A  52
 None
 1.27A 2dpzA-1s8hA:
21.0		 2dpzA-1s8hA:
64.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sh2 RNA POLYMERASE

(Norwalk virus) 		PF00680
(RdRP_1) 		4 LEU A 279
ALA A 198
ASP A 188
TYR A 161
 None
 1.34A 2dpzA-1sh2A:
undetectable		 2dpzA-1sh2A:
14.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vap PHOSPHOLIPASE A2

(Agkistrodon
piscivorus) 		PF00068
(Phospholip_A2_1) 		4 LEU A   2
HIS A  47
ASP A  48
TYR A  51
 None
 0.36A 2dpzA-1vapA:
21.8		 2dpzA-1vapA:
60.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vip PHOSPHOLIPASE A2

(Daboia russelii) 		PF00068
(Phospholip_A2_1) 		4 LEU A   2
HIS A  48
ASP A  49
TYR A  52
 None
 0.58A 2dpzA-1vipA:
22.2		 2dpzA-1vipA:
57.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vpi PHOSPHOLIPASE A2
INHIBITOR

(Vipera
ammodytes) 		PF00068
(Phospholip_A2_1) 		4 LEU A   2
ALA A  18
ASP A  49
TYR A  52
 None
 0.78A 2dpzA-1vpiA:
21.5		 2dpzA-1vpiA:
54.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xrs D-LYSINE
5,6-AMINOMUTASE BETA
SUBUNIT

(Acetoanaerobium
sticklandii) 		PF02310
(B12-binding)
PF16554
(OAM_dimer) 		4 LEU B 207
ALA B 176
ASP B 236
TYR B 235
 None
 1.23A 2dpzA-1xrsB:
undetectable		 2dpzA-1xrsB:
16.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1y75 PHOSPHOLIPASE A2
ISOFORM 5

(Naja
sagittifera) 		PF00068
(Phospholip_A2_1) 		4 ALA A  23
HIS A  48
TYR A  52
LYS A  64
 None
NAG  A 301 (-3.9A)
None
NAG  A 301 (-2.8A)
 0.98A 2dpzA-1y75A:
17.6		 2dpzA-1y75A:
37.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1y75 PHOSPHOLIPASE A2
ISOFORM 6

(Naja
sagittifera) 		PF00068
(Phospholip_A2_1) 		4 ALA B  23
HIS B  48
TYR B  52
LYS B  64
 None
 0.91A 2dpzA-1y75B:
18.1		 2dpzA-1y75B:
36.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1y75 PHOSPHOLIPASE A2
ISOFORM 6

(Naja
sagittifera) 		PF00068
(Phospholip_A2_1) 		4 HIS B  48
ASP B  49
TYR B  52
LYS B  64
 None
 0.46A 2dpzA-1y75B:
18.1		 2dpzA-1y75B:
36.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zl7 HYPOTENSIVE
PHOSPHOLIPASE A2

(Bothrops
jararacussu) 		PF00068
(Phospholip_A2_1) 		4 LEU A   2
HIS A  47
ASP A  48
TYR A  51
 None
None
CA  A1001 ( 2.3A)
None
 0.80A 2dpzA-1zl7A:
19.2		 2dpzA-1zl7A:
53.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bng MB2760

(Mycobacterium
tuberculosis) 		PF07858
(LEH) 		4 LEU A  40
ALA A  27
ASP A 122
TYR A  46
 None
 1.25A 2dpzA-2bngA:
undetectable		 2dpzA-2bngA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1o IGK-C PROTEIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU A 179
ALA A 130
HIS A 189
ASP A 151
 None
 1.35A 2dpzA-2c1oA:
undetectable		 2dpzA-2c1oA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dvz PUTATIVE EXPORTED
PROTEIN

(Bordetella
pertussis) 		PF03401
(TctC) 		4 LEU A  48
ALA A 263
ASP A 254
TYR A  16
 None
 1.19A 2dpzA-2dvzA:
undetectable		 2dpzA-2dvzA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f4p HYPOTHETICAL PROTEIN
TM1010

(Thermotoga
maritima) 		PF07883
(Cupin_2) 		4 ALA A  47
HIS A 105
ASP A  40
TYR A  39
 None
None
None
UNL  A 136 (-3.5A)
 1.26A 2dpzA-2f4pA:
undetectable		 2dpzA-2f4pA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gdu SUCROSE
PHOSPHORYLASE

(Bifidobacterium
adolescentis) 		PF00128
(Alpha-amylase)
PF09244
(DUF1964) 		4 LEU A 341
ALA A  49
HIS A  88
ASP A 162
 SUC  A2064 (-4.7A)
None
SUC  A2064 (-3.9A)
None
 1.13A 2dpzA-2gduA:
undetectable		 2dpzA-2gduA:
12.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h4c PHOSPHOLIPASE A2-II

(Daboia
siamensis) 		PF00068
(Phospholip_A2_1) 		4 ALA B   6
HIS B  48
ASP B  49
TYR B  52
 None
 1.07A 2dpzA-2h4cB:
19.5		 2dpzA-2h4cB:
55.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h4c PHOSPHOLIPASE A2-II

(Daboia
siamensis) 		PF00068
(Phospholip_A2_1) 		4 LEU B   2
HIS B  48
ASP B  49
TYR B  52
 None
 0.69A 2dpzA-2h4cB:
19.5		 2dpzA-2h4cB:
55.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h4c PHOSPHOLIPASE A2-III

(Daboia
siamensis) 		PF00068
(Phospholip_A2_1) 		4 ALA A  18
HIS A  48
ASP A  49
TYR A  52
 None
 0.77A 2dpzA-2h4cA:
20.4		 2dpzA-2h4cA:
55.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m6k FERRIENTEROBACTIN-BI
NDING PERIPLASMIC
PROTEIN

(Escherichia
coli) 		PF01497
(Peripla_BP_2) 		4 LEU A 115
ALA A 137
HIS A  37
ASP A  32
 None
 1.32A 2dpzA-2m6kA:
undetectable		 2dpzA-2m6kA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ory LIPASE

(Photobacterium
sp. M37) 		PF01764
(Lipase_3) 		4 LEU A 133
ALA A 211
ASP A 189
TYR A 115
 None
 1.16A 2dpzA-2oryA:
undetectable		 2dpzA-2oryA:
15.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2osn PHOSPHOLIPASE A2
ISOFORM 3

(Bungarus
caeruleus) 		PF00068
(Phospholip_A2_1) 		4 LEU A   4
HIS A  48
ASP A  49
TYR A  52
 None
 0.92A 2dpzA-2osnA:
17.3		 2dpzA-2osnA:
36.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qog PHOSPHOLIPASE A2 CB2

(Crotalus
durissus) 		PF00068
(Phospholip_A2_1) 		4 LEU A   2
ALA A  18
HIS A  48
TYR A  52
 None
 0.80A 2dpzA-2qogA:
20.2		 2dpzA-2qogA:
59.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qog PHOSPHOLIPASE A2 CB2

(Crotalus
durissus) 		PF00068
(Phospholip_A2_1) 		4 LEU A   2
ALA A  23
HIS A  48
TYR A  52
 None
 1.19A 2dpzA-2qogA:
20.2		 2dpzA-2qogA:
59.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qog PHOSPHOLIPASE A2 CB2

(Crotalus
durissus) 		PF00068
(Phospholip_A2_1) 		4 LEU A   2
HIS A  48
ASP A  49
TYR A  52
 None
 1.10A 2dpzA-2qogA:
20.2		 2dpzA-2qogA:
59.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvw GLP_546_48378_50642

(Giardia
intestinalis) 		PF00636
(Ribonuclease_3)
PF02170
(PAZ) 		4 LEU A 517
ALA A 428
HIS A 532
ASP A 528
 None
 1.23A 2dpzA-2qvwA:
undetectable		 2dpzA-2qvwA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wgy CYTOCHROME P450 130

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		4 ALA A  59
HIS A  52
ASP A 324
TYR A 328
 None
 1.31A 2dpzA-2wgyA:
undetectable		 2dpzA-2wgyA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III

(Thermus
thermophilus) 		PF00115
(COX1)
PF00510
(COX3) 		4 LEU A 747
ALA A 677
HIS A 775
ASP A 778
 None
 1.37A 2dpzA-2yevA:
undetectable		 2dpzA-2yevA:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxe PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Methanocaldococcus
jannaschii) 		PF01135
(PCMT) 		4 LEU A  75
ALA A  28
HIS A  91
TYR A 151
 None
 1.30A 2dpzA-2yxeA:
undetectable		 2dpzA-2yxeA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfh MANDELATE RACEMASE

(Vibrionales
bacterium
SWAT-3) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 212
ALA A 221
HIS A 206
ASP A 207
 None
 1.34A 2dpzA-3dfhA:
undetectable		 2dpzA-3dfhA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfh MANDELATE RACEMASE

(Vibrionales
bacterium
SWAT-3) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 359
ALA A 319
HIS A 337
TYR A 149
 None
 1.37A 2dpzA-3dfhA:
undetectable		 2dpzA-3dfhA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmk DOWN SYNDROME CELL
ADHESION MOLECULE
(DSCAM) ISOFORM
1.30.30, N-TERMINAL
EIGHT IG DOMAINS

(Drosophila
melanogaster) 		PF07679
(I-set)
PF13927
(Ig_3) 		4 LEU A 430
ALA A 516
ASP A 439
TYR A 441
 None
 1.32A 2dpzA-3dmkA:
undetectable		 2dpzA-3dmkA:
10.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g8g PHOSPHOLIPASE A2,
AMMODYTOXIN A

(Vipera
ammodytes) 		PF00068
(Phospholip_A2_1) 		4 LEU A   2
HIS A  47
ASP A  48
TYR A  51
 None
 0.45A 2dpzA-3g8gA:
22.5		 2dpzA-3g8gA:
80.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4i GLYCOSYLTRANSFERASE
GTFA,
GLYCOSYLTRANSFERASE

(Actinoplanes
teichomyceticus;
Amycolatopsis
orientalis) 		PF03033
(Glyco_transf_28)
PF04101
(Glyco_tran_28_C) 		4 LEU A 185
ALA A 200
ASP A 315
TYR A 318
 None
None
U2F  A 547 (-2.7A)
None
 0.83A 2dpzA-3h4iA:
undetectable		 2dpzA-3h4iA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF00128
(Alpha-amylase)
PF09196
(DUF1953) 		4 ALA A 454
ASP A 671
TYR A 672
LYS A 666
 None
 1.30A 2dpzA-3hjeA:
undetectable		 2dpzA-3hjeA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4x TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE

(Aspergillus
fumigatus) 		PF11991
(Trp_DMAT) 		4 LEU A 395
ALA A 357
HIS A 389
ASP A 388
 None
 1.23A 2dpzA-3i4xA:
undetectable		 2dpzA-3i4xA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jc7 DNA REPLICATION
COMPLEX GINS PROTEIN
PSF2

(Saccharomyces
cerevisiae) 		PF05916
(Sld5) 		4 LEU B  93
ALA B 130
HIS B 135
ASP B 136
 None
 1.19A 2dpzA-3jc7B:
undetectable		 2dpzA-3jc7B:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kwl UNCHARACTERIZED
PROTEIN

(Helicobacter
pylori) 		no annotation 4 LEU A 245
ALA A 404
ASP A 273
TYR A 272
 None
 1.15A 2dpzA-3kwlA:
undetectable		 2dpzA-3kwlA:
11.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p2p PHOSPHOLIPASE A2

(Sus scrofa) 		PF00068
(Phospholip_A2_1) 		4 LEU A   2
HIS A  48
ASP A  49
TYR A  52
 None
None
CA  A 125 (-2.1A)
None
 0.75A 2dpzA-3p2pA:
18.3		 2dpzA-3p2pA:
41.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qpx FAB C2507 LIGHT
CHAIN

(Homo sapiens;
Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 178
ALA L 129
HIS L 188
ASP L 150
 None
None
CD  L 226 (-3.4A)
CD  L 226 (-3.4A)
 1.25A 2dpzA-3qpxL:
undetectable		 2dpzA-3qpxL:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ucx SHORT CHAIN
DEHYDROGENASE

(Mycolicibacterium
smegmatis) 		PF13561
(adh_short_C2) 		4 LEU A  59
ALA A  37
HIS A  73
ASP A  76
 None
 1.34A 2dpzA-3ucxA:
undetectable		 2dpzA-3ucxA:
18.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v9m PHOSPHOLIPASE A2
ISOZYME PA-11

(Pseudechis
australis) 		PF00068
(Phospholip_A2_1) 		4 LEU A   2
HIS A  48
ASP A  49
TYR A  52
 EDO  A 201 ( 4.7A)
EDO  A 201 ( 4.0A)
CA  A 205 (-2.2A)
EDO  A 201 ( 4.8A)
 0.53A 2dpzA-3v9mA:
18.0		 2dpzA-3v9mA:
41.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vbz PHOSPHOLIPASE A2
HOMOLOG, TAIPOXIN
BETA CHAIN

(Oxyuranus
scutellatus) 		PF00068
(Phospholip_A2_1) 		4 ALA A  19
HIS A  48
ASP A  49
TYR A  52
 None
 0.67A 2dpzA-3vbzA:
18.1		 2dpzA-3vbzA:
36.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vbz PHOSPHOLIPASE A2
HOMOLOG, TAIPOXIN
BETA CHAIN

(Oxyuranus
scutellatus) 		PF00068
(Phospholip_A2_1) 		4 LEU A   2
HIS A  48
ASP A  49
TYR A  52
 None
 0.71A 2dpzA-3vbzA:
18.1		 2dpzA-3vbzA:
36.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vzu OUTER MEMBRANE
PROTEIN

(Neisseria
meningitidis) 		PF00267
(Porin_1) 		4 LEU X 121
ALA X 236
ASP X 296
TYR X 295
 None
 1.27A 2dpzA-3vzuX:
undetectable		 2dpzA-3vzuX:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci6 PROTEIN KINASE YOPO

(Yersinia
enterocolitica) 		PF00069
(Pkinase)
PF09632
(Rac1) 		4 LEU B 190
ALA B 176
HIS B 265
ASP B 321
 None
 1.30A 2dpzA-4ci6B:
undetectable		 2dpzA-4ci6B:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d1e ALPHA-ACTININ-2

(Homo sapiens) 		PF00307
(CH)
PF00435
(Spectrin)
PF08726
(EFhand_Ca_insen) 		4 LEU A 565
ALA A 535
HIS A 558
ASP A 622
 MLZ  A 562 ( 4.2A)
None
MLZ  A 562 ( 4.1A)
MLZ  A 562 ( 3.8A)
 1.34A 2dpzA-4d1eA:
undetectable		 2dpzA-4d1eA:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fuv PORIN PROTEIN
ASSOCIATED WITH
IMIPENEM RESISTANCE

(Acinetobacter
baumannii) 		no annotation 4 LEU A 214
ALA A 102
ASP A 107
TYR A 108
 None
None
None
C8E  A 303 ( 4.4A)
 1.14A 2dpzA-4fuvA:
undetectable		 2dpzA-4fuvA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfh DNA TOPOISOMERASE 2

(Saccharomyces
cerevisiae) 		PF00204
(DNA_gyraseB)
PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF02518
(HATPase_c)
PF16898
(TOPRIM_C) 		4 ALA A 459
ASP A 526
TYR A 602
LYS A 607
 None
 1.26A 2dpzA-4gfhA:
undetectable		 2dpzA-4gfhA:
7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gis ENOLASE

(Vibrio harveyi) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 210
ALA A 219
HIS A 204
ASP A 205
 None
None
None
MG  A 405 (-2.7A)
 1.37A 2dpzA-4gisA:
undetectable		 2dpzA-4gisA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jfz FAB LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 179
ALA L 130
HIS L 189
ASP L 151
 None
 1.35A 2dpzA-4jfzL:
undetectable		 2dpzA-4jfzL:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxk OXIDOREDUCTASE

(Rhodococcus
opacus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A 286
ALA A 133
HIS A  89
ASP A  67
 None
 1.30A 2dpzA-4jxkA:
undetectable		 2dpzA-4jxkA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kqn D-HYDANTOINASE

(Bacillus sp.
AR9) 		PF01979
(Amidohydro_1) 		4 ALA A 154
HIS A 239
ASP A 315
LYS A 150
 ALA  A 154 ( 0.0A)
HIS  A 239 (-1.0A)
ASP  A 315 (-0.6A)
LYS  A 150 ( 0.0A)
 1.19A 2dpzA-4kqnA:
undetectable		 2dpzA-4kqnA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kyz DESIGNED PROTEIN
OR327

(synthetic
construct) 		no annotation 4 LEU A  36
ALA A  45
ASP A  18
TYR A  19
 None
 1.36A 2dpzA-4kyzA:
undetectable		 2dpzA-4kyzA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lct COP9 SIGNALOSOME
COMPLEX SUBUNIT 1

(Arabidopsis
thaliana) 		PF01399
(PCI)
PF10602
(RPN7) 		4 LEU A 322
ASP A 336
TYR A 335
LYS A 318
 None
 1.25A 2dpzA-4lctA:
undetectable		 2dpzA-4lctA:
17.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rfp ACIDIC PHOSPHOLIPASE
A2 5

(Trimeresurus
stejnegeri) 		PF00068
(Phospholip_A2_1) 		4 LEU A   2
HIS A  47
ASP A  48
TYR A  51
 None
 0.72A 2dpzA-4rfpA:
20.3		 2dpzA-4rfpA:
53.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ufs LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 5
R-SPONDIN-2

(Homo sapiens) 		PF00560
(LRR_1)
PF01462
(LRRNT)
PF13855
(LRR_8)
PF15913
(Furin-like_2) 		4 ALA B  87
HIS A 265
ASP A 290
TYR A 289
 None
 1.12A 2dpzA-4ufsB:
undetectable		 2dpzA-4ufsB:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xqk LLABIII

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII)
PF13156
(Mrr_cat_2) 		4 LEU A1351
ALA A1518
HIS A1417
TYR A1413
 None
 1.36A 2dpzA-4xqkA:
undetectable		 2dpzA-4xqkA:
6.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ye4 LIGHT CHAIN OF HJ16

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 186
ALA L 137
HIS L 196
ASP L 158
 None
 1.23A 2dpzA-4ye4L:
undetectable		 2dpzA-4ye4L:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yke MRE11

(Chaetomium
thermophilum) 		PF00149
(Metallophos)
PF04152
(Mre11_DNA_bind) 		4 LEU A 270
ALA A 275
ASP A  32
TYR A  22
 None
 1.29A 2dpzA-4ykeA:
undetectable		 2dpzA-4ykeA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yue S4B6 FAB LIGHT CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU L 182
ALA L 133
HIS L 192
ASP L 154
 None
 1.28A 2dpzA-4yueL:
undetectable		 2dpzA-4yueL:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eb5 HNL ISOENZYME 5

(Prunus dulcis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 LEU A 320
ALA A 115
HIS A 460
TYR A 458
 None
None
FAD  A 601 (-4.0A)
010  A 609 (-4.5A)
 1.37A 2dpzA-5eb5A:
undetectable		 2dpzA-5eb5A:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fuk MROUPO

(Marasmius
rotula) 		PF01328
(Peroxidase_2) 		4 LEU A 138
ALA A  88
HIS A 131
ASP A 219
 None
 1.34A 2dpzA-5fukA:
undetectable		 2dpzA-5fukA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i7n MAOC-LIKE
DEHYDRATASE

(Mycobacteroides
abscessus) 		PF01575
(MaoC_dehydratas)
PF13452
(MaoC_dehydrat_N) 		4 LEU A  89
ALA A 251
HIS A 242
ASP A 237
 None
 1.29A 2dpzA-5i7nA:
undetectable		 2dpzA-5i7nA:
14.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tfv BASIC PHOSPHOLIPASE
A2 MYOTOXIN III

(Bothrops asper) 		PF00068
(Phospholip_A2_1) 		4 LEU A   2
HIS A  48
ASP A  49
TYR A  52
 None
 0.83A 2dpzA-5tfvA:
21.0		 2dpzA-5tfvA:
68.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ucd NAD(P)-DEPENDENT
BENZALDEHYDE
DEHYDROGENASE

(Pseudomonas
putida) 		PF00171
(Aldedh) 		4 LEU A 125
ALA A  67
HIS A 418
TYR A 417
 ZBZ  A 249 ( 4.6A)
None
None
None
 1.15A 2dpzA-5ucdA:
undetectable		 2dpzA-5ucdA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4z RIBOFLAVIN LYASE

(Herbiconiux) 		no annotation 4 ALA A 345
HIS A 158
ASP A 159
TYR A 162
 None
9WY  A 501 (-3.8A)
None
None
 0.84A 2dpzA-5w4zA:
undetectable		 2dpzA-5w4zA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z06 BDI_3064 PROTEIN

(Parabacteroides
distasonis) 		no annotation 4 LEU A 683
ALA A 327
HIS A 387
ASP A 408
 GOL  A 807 (-4.3A)
None
GOL  A 807 ( 4.6A)
None
 1.26A 2dpzA-5z06A:
undetectable		 2dpzA-5z06A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk1 UDP-GLYCOSYLTRANSFER
ASE 79

(Oryza sativa) 		no annotation 4 LEU A 210
ALA A 238
ASP A 120
TYR A 119
 None
 1.12A 2dpzA-6bk1A:
undetectable		 2dpzA-6bk1A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dk2 -

(-) 		no annotation 4 LEU A 135
ALA A 496
HIS A  59
TYR A  55
 None
 1.31A 2dpzA-6dk2A:
undetectable		 2dpzA-6dk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ek6 LYSINE-SPECIFIC
DEMETHYLASE
5B,LYSINE-SPECIFIC
DEMETHYLASE 5B

(Homo sapiens) 		no annotation 4 LEU A 472
ALA A 477
HIS A 503
ASP A 502
 None
 1.35A 2dpzA-6ek6A:
undetectable		 2dpzA-6ek6A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d ATP SYNTHASE ALPHA
CHAIN, MITOCHONDRIAL

(Trypanosoma
brucei) 		no annotation 4 LEU A 103
ALA A 262
HIS A 121
ASP A  85
 None
 1.37A 2dpzA-6f5dA:
undetectable		 2dpzA-6f5dA:
15.70