SIMILAR PATTERNS OF AMINO ACIDS FOR 2DG9_A_RAPA501_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		6 TYR A 131
ASP A 142
VAL A 158
ILE A 159
TYR A 185
PHE A 202
 None
 0.57A 2dg9A-1fd9A:
15.9		 2dg9A-1fd9A:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fkk FK506 BINDING
PROTEIN

(Bos taurus) 		PF00254
(FKBP_C) 		7 TYR A  26
ASP A  37
ILE A  56
TYR A  82
HIS A  87
ILE A  90
PHE A  99
 None
 0.77A 2dg9A-1fkkA:
22.0		 2dg9A-1fkkA:
96.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fkk FK506 BINDING
PROTEIN

(Bos taurus) 		PF00254
(FKBP_C) 		9 TYR A  26
ASP A  37
PHE A  46
GLU A  54
VAL A  55
ILE A  56
TYR A  82
ILE A  90
PHE A  99
 None
 0.49A 2dg9A-1fkkA:
22.0		 2dg9A-1fkkA:
96.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fkk FK506 BINDING
PROTEIN

(Bos taurus) 		PF00254
(FKBP_C) 		5 TYR A  26
PHE A  46
GLU A  54
VAL A  55
ILE A  91
 None
 1.08A 2dg9A-1fkkA:
22.0		 2dg9A-1fkkA:
96.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR

(Trypanosoma
cruzi) 		PF00254
(FKBP_C) 		7 TYR A  92
ASP A 103
GLU A 118
VAL A 119
ILE A 120
TYR A 146
PHE A 163
 None
 0.71A 2dg9A-1jvwA:
15.2		 2dg9A-1jvwA:
41.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jvw MACROPHAGE
INFECTIVITY
POTENTIATOR

(Trypanosoma
cruzi) 		PF00254
(FKBP_C) 		5 TYR A  92
PHE A 114
ILE A 120
TYR A 146
PHE A 163
 None
 0.99A 2dg9A-1jvwA:
15.2		 2dg9A-1jvwA:
41.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kt1 FK506-BINDING
PROTEIN FKBP51

(Saimiri
boliviensis) 		PF00254
(FKBP_C)
PF00515
(TPR_1)
PF13181
(TPR_8) 		5 TYR A  57
PHE A  77
ILE A  87
ILE A 122
PHE A 130
 None
 1.02A 2dg9A-1kt1A:
15.5		 2dg9A-1kt1A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kt1 FK506-BINDING
PROTEIN FKBP51

(Saimiri
boliviensis) 		PF00254
(FKBP_C)
PF00515
(TPR_1)
PF13181
(TPR_8) 		5 TYR A  57
PHE A  77
ILE A  87
TYR A 113
PHE A 130
 None
 0.84A 2dg9A-1kt1A:
15.5		 2dg9A-1kt1A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kt1 FK506-BINDING
PROTEIN FKBP51

(Saimiri
boliviensis) 		PF00254
(FKBP_C)
PF00515
(TPR_1)
PF13181
(TPR_8) 		5 TYR A  57
PHE A  77
VAL A  86
TYR A 113
PHE A 130
 None
 0.76A 2dg9A-1kt1A:
15.5		 2dg9A-1kt1A:
23.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n1a FKBP52

(Homo sapiens) 		PF00254
(FKBP_C) 		7 TYR A  57
ASP A  68
PHE A  77
VAL A  86
ILE A  87
TYR A 113
PHE A 130
 None
 0.65A 2dg9A-1n1aA:
17.8		 2dg9A-1n1aA:
44.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n1a FKBP52

(Homo sapiens) 		PF00254
(FKBP_C) 		5 TYR A  57
ASP A  68
PHE A  77
VAL A  86
ILE A 122
 None
 1.03A 2dg9A-1n1aA:
17.8		 2dg9A-1n1aA:
44.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oi4 HYPOTHETICAL PROTEIN
YHBO

(Escherichia
coli) 		PF01965
(DJ-1_PfpI) 		5 ASP A  44
PHE A  39
VAL A  28
ILE A  26
LEU A  91
 None
 1.02A 2dg9A-1oi4A:
undetectable		 2dg9A-1oi4A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1osy IMMUNOMODULATORY
PROTEIN FIP-FVE

(Flammulina
velutipes) 		PF09259
(Fve) 		5 TYR A  79
VAL A  53
ILE A  91
ILE A 108
PHE A  76
 None
 1.18A 2dg9A-1osyA:
undetectable		 2dg9A-1osyA:
22.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pbk FKBP25

(Homo sapiens) 		PF00254
(FKBP_C) 		6 TYR A 135
ASP A 146
VAL A 171
ILE A 172
TYR A 198
PHE A 216
 RAP  A 225 (-3.9A)
RAP  A 225 (-3.0A)
RAP  A 225 (-3.5A)
RAP  A 225 (-3.9A)
RAP  A 225 (-4.6A)
None
 0.35A 2dg9A-1pbkA:
19.1		 2dg9A-1pbkA:
42.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1q6h FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA

(Escherichia
coli) 		PF00254
(FKBP_C)
PF01346
(FKBP_N) 		6 TYR A 146
ASP A 157
VAL A 173
ILE A 174
TYR A 200
PHE A 216
 None
 0.57A 2dg9A-1q6hA:
15.7		 2dg9A-1q6hA:
31.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r9h FK506 BINDING
PROTEIN FAMILY

(Caenorhabditis
elegans) 		PF00254
(FKBP_C) 		6 TYR A  40
ASP A  51
PHE A  60
VAL A  69
ILE A  70
PHE A 113
 None
 0.55A 2dg9A-1r9hA:
19.7		 2dg9A-1r9hA:
43.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r9h FK506 BINDING
PROTEIN FAMILY

(Caenorhabditis
elegans) 		PF00254
(FKBP_C) 		5 TYR A  40
ASP A  51
PHE A  60
VAL A  69
ILE A 105
 None
 1.15A 2dg9A-1r9hA:
19.7		 2dg9A-1r9hA:
43.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r9h FK506 BINDING
PROTEIN FAMILY

(Caenorhabditis
elegans) 		PF00254
(FKBP_C) 		6 TYR A  40
PHE A  60
VAL A  69
ILE A  70
TYR A  96
PHE A 113
 None
 0.28A 2dg9A-1r9hA:
19.7		 2dg9A-1r9hA:
43.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u79 FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
3

(Arabidopsis
thaliana) 		PF00254
(FKBP_C) 		7 TYR A  37
ASP A  48
GLU A  65
VAL A  66
ILE A  67
TYR A  99
PHE A 121
 None
 0.74A 2dg9A-1u79A:
17.2		 2dg9A-1u79A:
36.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1yat FK506 BINDING
PROTEIN

(Saccharomyces
cerevisiae) 		PF00254
(FKBP_C) 		7 TYR A  26
ASP A  37
PHE A  46
VAL A  55
ILE A  56
TYR A  82
PHE A  99
 FK5  A 108 ( 4.0A)
FK5  A 108 ( 3.3A)
FK5  A 108 ( 4.0A)
FK5  A 108 ( 3.4A)
FK5  A 108 ( 3.7A)
FK5  A 108 ( 4.7A)
None
 0.42A 2dg9A-1yatA:
20.1		 2dg9A-1yatA:
56.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygp YEAST GLYCOGEN
PHOSPHORYLASE

(Saccharomyces
cerevisiae) 		PF00343
(Phosphorylase) 		5 PHE A 777
VAL A 741
ILE A 745
LEU A 742
ILE A 623
 None
 1.13A 2dg9A-1ygpA:
undetectable		 2dg9A-1ygpA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dy0 ADENINE
PHOSPHORIBOSYLTRANSF
ERASE

(Escherichia
coli) 		PF00156
(Pribosyltran) 		5 ASP A 127
VAL A  74
ILE A  45
LEU A  48
TYR A  41
 None
 1.13A 2dg9A-2dy0A:
undetectable		 2dg9A-2dy0A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ec5 DERMONECROTIC TOXIN

(Pasteurella
multocida) 		PF11647
(MLD) 		5 TYR A1017
GLU A 845
VAL A 722
ILE A 723
PHE A 716
 None
 1.18A 2dg9A-2ec5A:
undetectable		 2dg9A-2ec5A:
9.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2pbc FK506-BINDING
PROTEIN 2

(Homo sapiens) 		PF00254
(FKBP_C) 		7 TYR A  56
ASP A  67
PHE A  76
VAL A  85
ILE A  86
TYR A 112
PHE A 129
 PEG  A 201 (-4.4A)
None
PEG  A 201 ( 3.9A)
PEG  A 201 (-3.6A)
PEG  A 201 (-3.8A)
None
None
 0.74A 2dg9A-2pbcA:
15.4		 2dg9A-2pbcA:
46.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2pbc FK506-BINDING
PROTEIN 2

(Homo sapiens) 		PF00254
(FKBP_C) 		5 TYR A  56
ASP A  67
PHE A  76
VAL A  85
ILE A 121
 PEG  A 201 (-4.4A)
None
PEG  A 201 ( 3.9A)
PEG  A 201 (-3.6A)
None
 0.96A 2dg9A-2pbcA:
15.4		 2dg9A-2pbcA:
46.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vn1 70 KDA
PEPTIDYLPROLYL
ISOMERASE

(Plasmodium
falciparum) 		PF00254
(FKBP_C) 		8 TYR A  44
ASP A  56
PHE A  65
GLU A  73
VAL A  74
ILE A  75
TYR A 101
PHE A 118
 FK5  A 501 (-4.1A)
FK5  A 501 (-3.4A)
FK5  A 501 (-4.1A)
None
FK5  A 501 (-3.5A)
FK5  A 501 (-4.3A)
FK5  A 501 (-4.7A)
FK5  A 501 (-4.8A)
 0.55A 2dg9A-2vn1A:
19.4		 2dg9A-2vn1A:
39.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2vn1 70 KDA
PEPTIDYLPROLYL
ISOMERASE

(Plasmodium
falciparum) 		PF00254
(FKBP_C) 		5 TYR A  44
PHE A  65
GLU A  73
VAL A  74
ILE A 110
 FK5  A 501 (-4.1A)
FK5  A 501 (-4.1A)
None
FK5  A 501 (-3.5A)
None
 1.16A 2dg9A-2vn1A:
19.4		 2dg9A-2vn1A:
39.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2y78 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Burkholderia
pseudomallei) 		PF00254
(FKBP_C) 		7 TYR A  33
ASP A  44
PHE A  53
VAL A  62
ILE A  63
TYR A  89
PHE A 106
 None
 0.70A 2dg9A-2y78A:
17.8		 2dg9A-2y78A:
46.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2y78 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Burkholderia
pseudomallei) 		PF00254
(FKBP_C) 		5 TYR A  33
ASP A  44
PHE A  53
VAL A  62
ILE A  98
 None
 1.18A 2dg9A-2y78A:
17.8		 2dg9A-2y78A:
46.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxl 450AA LONG
HYPOTHETICAL FMU
PROTEIN

(Pyrococcus
horikoshii) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N) 		5 GLU A 206
VAL A 212
ILE A 224
LEU A 222
TYR A 228
 None
 1.14A 2dg9A-2yxlA:
undetectable		 2dg9A-2yxlA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3beo UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Bacillus
anthracis) 		PF02350
(Epimerase_2) 		5 GLU A  26
VAL A 362
ILE A 365
LEU A 366
ILE A  37
 None
 1.16A 2dg9A-3beoA:
undetectable		 2dg9A-3beoA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cj1 ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE 2

(Rattus
norvegicus) 		PF01150
(GDA1_CD39) 		5 GLU A  63
ILE A 448
LEU A 442
TYR A 229
ILE A 181
 None
 0.96A 2dg9A-3cj1A:
undetectable		 2dg9A-3cj1A:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cq9 UNCHARACTERIZED
PROTEIN LP_1622

(Lactobacillus
plantarum) 		PF04263
(TPK_catalytic) 		5 ASP A  95
ILE A 129
HIS A  98
ILE A   4
PHE A  89
 None
 1.17A 2dg9A-3cq9A:
undetectable		 2dg9A-3cq9A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3etv PROTEIN TRANSPORT
PROTEIN TIP20,
PROTEIN TRANSPORT
PROTEIN DSL1 CHIMERA

(Saccharomyces
cerevisiae) 		PF11988
(Dsl1_N) 		5 TYR A 179
PHE A 191
VAL A 204
LEU A 208
ILE A 138
 None
 1.10A 2dg9A-3etvA:
undetectable		 2dg9A-3etvA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ez9 PARA

(Salmonella
enterica) 		PF13614
(AAA_31) 		5 GLU A 173
VAL A 192
ILE A 193
LEU A 188
ILE A 251
 None
 1.16A 2dg9A-3ez9A:
undetectable		 2dg9A-3ez9A:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f41 PHYTASE

(Mitsuokella
multacida) 		PF14566
(PTPlike_phytase) 		5 GLU A 107
ILE A 113
LEU A 114
HIS A 249
PHE A 124
 None
 0.99A 2dg9A-3f41A:
undetectable		 2dg9A-3f41A:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gre SERINE/THREONINE-PRO
TEIN KINASE VPS15

(Saccharomyces
cerevisiae) 		no annotation 5 GLU A1281
ILE A1304
LEU A1302
TYR A1286
PHE A1316
 None
 1.14A 2dg9A-3greA:
undetectable		 2dg9A-3greA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gsi N,N-DIMETHYLGLYCINE
OXIDASE

(Arthrobacter
globiformis) 		PF01266
(DAO)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF16350
(FAO_M) 		5 VAL A 555
ILE A 553
LEU A 565
ILE A 729
PHE A 576
 None
 1.11A 2dg9A-3gsiA:
undetectable		 2dg9A-3gsiA:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jxv 70 KDA
PEPTIDYL-PROLYL
ISOMERASE

(Triticum
aestivum) 		PF00254
(FKBP_C) 		5 PHE A 321
VAL A 330
ILE A 331
LEU A 334
TYR A 357
 None
 0.48A 2dg9A-3jxvA:
17.9		 2dg9A-3jxvA:
25.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mfq HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA

(Streptococcus
suis) 		PF01297
(ZnuA) 		5 VAL A 305
ILE A 186
LEU A 183
ILE A 240
PHE A 209
 None
 1.17A 2dg9A-3mfqA:
undetectable		 2dg9A-3mfqA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nio GUANIDINOBUTYRASE

(Pseudomonas
aeruginosa) 		PF00491
(Arginase) 		5 ASP A 284
VAL A 238
ILE A 281
LEU A 280
ILE A 135
 None
 0.95A 2dg9A-3nioA:
undetectable		 2dg9A-3nioA:
17.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o5d PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		6 TYR A  57
ASP A  68
PHE A  77
VAL A  86
ILE A  87
PHE A 130
 None
 0.62A 2dg9A-3o5dA:
18.5		 2dg9A-3o5dA:
32.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o5d PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		5 TYR A  57
ASP A  68
PHE A  77
VAL A  86
ILE A 122
 None
 1.12A 2dg9A-3o5dA:
18.5		 2dg9A-3o5dA:
32.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o5d PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		6 TYR A  57
PHE A  77
VAL A  86
ILE A  87
TYR A 113
PHE A 130
 None
 0.48A 2dg9A-3o5dA:
18.5		 2dg9A-3o5dA:
32.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o5e PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		7 TYR A  57
ASP A  68
PHE A  77
VAL A  86
ILE A  87
TYR A 113
PHE A 130
 None
 0.73A 2dg9A-3o5eA:
18.6		 2dg9A-3o5eA:
38.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o5e PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		5 TYR A  57
ASP A  68
PHE A  77
VAL A  86
ILE A 122
 None
 1.08A 2dg9A-3o5eA:
18.6		 2dg9A-3o5eA:
38.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pa7 70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE

(Plasmodium
vivax) 		PF00254
(FKBP_C) 		5 ASP A  55
PHE A  64
GLU A  72
VAL A  73
ILE A  74
 None
 1.05A 2dg9A-3pa7A:
19.2		 2dg9A-3pa7A:
38.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pa7 70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE

(Plasmodium
vivax) 		PF00254
(FKBP_C) 		5 PHE A  64
GLU A  72
VAL A  73
ILE A  74
TYR A 100
 None
 0.80A 2dg9A-3pa7A:
19.2		 2dg9A-3pa7A:
38.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pa7 70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE

(Plasmodium
vivax) 		PF00254
(FKBP_C) 		6 TYR A  43
ASP A  55
PHE A  64
VAL A  73
ILE A  74
PHE A 117
 None
 0.61A 2dg9A-3pa7A:
19.2		 2dg9A-3pa7A:
38.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pa7 70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE

(Plasmodium
vivax) 		PF00254
(FKBP_C) 		5 TYR A  43
ASP A  55
PHE A  64
VAL A  73
ILE A 109
 None
 1.04A 2dg9A-3pa7A:
19.2		 2dg9A-3pa7A:
38.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pa7 70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE

(Plasmodium
vivax) 		PF00254
(FKBP_C) 		6 TYR A  43
PHE A  64
VAL A  73
ILE A  74
TYR A 100
PHE A 117
 None
 0.35A 2dg9A-3pa7A:
19.2		 2dg9A-3pa7A:
38.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ue9 ADENYLOSUCCINATE
SYNTHETASE

(Burkholderia
thailandensis) 		PF00709
(Adenylsucc_synt) 		5 PHE A  43
VAL A  15
ILE A 272
LEU A 269
ILE A 339
 None
 1.10A 2dg9A-3ue9A:
undetectable		 2dg9A-3ue9A:
13.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bf8 FPR4

(Saccharomyces
cerevisiae) 		PF00254
(FKBP_C) 		7 TYR A 313
ASP A 324
GLU A 340
VAL A 341
ILE A 342
TYR A 368
PHE A 384
 None
 0.99A 2dg9A-4bf8A:
16.0		 2dg9A-4bf8A:
37.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4bf8 FPR4

(Saccharomyces
cerevisiae) 		PF00254
(FKBP_C) 		7 TYR A 313
ASP A 324
PHE A 332
GLU A 340
VAL A 341
ILE A 342
PHE A 384
 None
 1.13A 2dg9A-4bf8A:
16.0		 2dg9A-4bf8A:
37.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dz3 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Burkholderia
pseudomallei) 		PF00254
(FKBP_C) 		7 TYR A  33
ASP A  44
PHE A  53
VAL A  62
ILE A  63
TYR A  89
PHE A 106
 FK5  A 201 ( 3.9A)
FK5  A 201 (-3.5A)
FK5  A 201 (-4.1A)
FK5  A 201 ( 3.6A)
FK5  A 201 (-3.8A)
FK5  A 201 (-4.7A)
FK5  A 201 (-4.8A)
 0.38A 2dg9A-4dz3A:
18.6		 2dg9A-4dz3A:
53.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4iqc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B

(Homo sapiens) 		PF00254
(FKBP_C) 		7 TYR A  26
ASP A  37
PHE A  46
GLU A  54
ILE A  56
TYR A  82
PHE A  99
 None
 0.81A 2dg9A-4iqcA:
22.2		 2dg9A-4iqcA:
83.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4iqc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B

(Homo sapiens) 		PF00254
(FKBP_C) 		7 TYR A  26
ASP A  37
PHE A  46
ILE A  56
TYR A  82
HIS A  87
PHE A  99
 None
 0.78A 2dg9A-4iqcA:
22.2		 2dg9A-4iqcA:
83.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4iqc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B

(Homo sapiens) 		PF00254
(FKBP_C) 		7 TYR A  26
PHE A  46
GLU A  54
VAL A  55
ILE A  56
TYR A  82
PHE A  99
 None
 0.77A 2dg9A-4iqcA:
22.2		 2dg9A-4iqcA:
83.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4iqc PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B

(Homo sapiens) 		PF00254
(FKBP_C) 		7 TYR A  26
PHE A  46
VAL A  55
ILE A  56
TYR A  82
HIS A  87
PHE A  99
 None
 0.69A 2dg9A-4iqcA:
22.2		 2dg9A-4iqcA:
83.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jwx GLUN2A

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		5 VAL A 109
ILE A  11
LEU A   9
ILE A  66
PHE A  76
 None
 0.91A 2dg9A-4jwxA:
undetectable		 2dg9A-4jwxA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4

(Homo sapiens) 		PF00254
(FKBP_C) 		6 TYR A  57
ASP A  68
PHE A  77
VAL A  86
ILE A  87
PHE A 130
 None
None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
DMS  A 304 (-4.3A)
 0.52A 2dg9A-4lawA:
19.0		 2dg9A-4lawA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4

(Homo sapiens) 		PF00254
(FKBP_C) 		5 TYR A  57
ASP A  68
PHE A  77
VAL A  86
ILE A 122
 None
None
None
DMS  A 304 (-3.5A)
None
 0.92A 2dg9A-4lawA:
19.0		 2dg9A-4lawA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4

(Homo sapiens) 		PF00254
(FKBP_C) 		6 TYR A  57
PHE A  77
VAL A  86
ILE A  87
TYR A 113
PHE A 130
 None
None
DMS  A 304 (-3.5A)
DMS  A 304 (-3.8A)
None
DMS  A 304 (-4.3A)
 0.47A 2dg9A-4lawA:
19.0		 2dg9A-4lawA:
23.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nnr PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2

(Homo sapiens) 		PF00254
(FKBP_C) 		7 TYR A  56
ASP A  67
PHE A  76
VAL A  85
ILE A  86
TYR A 112
PHE A 129
 FK5  A 201 (-4.1A)
FK5  A 201 (-3.4A)
FK5  A 201 (-4.0A)
FK5  A 201 (-3.4A)
FK5  A 201 (-3.8A)
FK5  A 201 (-4.5A)
FK5  A 201 (-4.9A)
 0.43A 2dg9A-4nnrA:
15.9		 2dg9A-4nnrA:
39.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o0m CIRCADIAN CLOCK
PROTEIN KINASE KAIC

(Thermosynechococcus
elongatus) 		PF06745
(ATPase) 		5 PHE A 152
GLU A 198
ILE A 145
ILE A 128
PHE A  77
 None
 1.14A 2dg9A-4o0mA:
undetectable		 2dg9A-4o0mA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4odm PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD

(Thermus
thermophilus) 		PF00254
(FKBP_C) 		7 TYR A  13
ASP A  23
ILE A  37
LEU A  40
TYR A  63
HIS A 119
PHE A 128
 None
 1.03A 2dg9A-4odmA:
12.0		 2dg9A-4odmA:
23.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4odr PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA

(Homo sapiens;
Thermus
thermophilus) 		PF00254
(FKBP_C) 		7 TYR A  13
ASP A  23
ILE A  37
LEU A  36
TYR A  63
HIS A  68
ILE A  71
 FK5  A 201 ( 3.6A)
FK5  A 201 (-3.6A)
FK5  A 201 (-3.9A)
FK5  A 201 (-3.8A)
FK5  A 201 (-4.4A)
None
FK5  A 201 ( 4.1A)
 1.33A 2dg9A-4odrA:
13.6		 2dg9A-4odrA:
33.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4odr PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA

(Homo sapiens;
Thermus
thermophilus) 		PF00254
(FKBP_C) 		7 TYR A  13
ASP A  23
ILE A  37
LEU A  40
TYR A  63
ILE A  71
PHE A  80
 FK5  A 201 ( 3.6A)
FK5  A 201 (-3.6A)
FK5  A 201 (-3.9A)
FK5  A 201 (-4.5A)
FK5  A 201 (-4.4A)
FK5  A 201 ( 4.1A)
FK5  A 201 ( 4.8A)
 0.76A 2dg9A-4odrA:
13.6		 2dg9A-4odrA:
33.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovq TRAP DICARBOXYLATE
ABC TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Roseobacter
denitrificans) 		PF03480
(DctP) 		5 TYR A 308
PHE A 309
ILE A 108
LEU A 105
ILE A 126
 None
 1.17A 2dg9A-4ovqA:
undetectable		 2dg9A-4ovqA:
15.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r0x PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		6 TYR A  57
ASP A  68
PHE A  77
VAL A  86
ILE A  87
PHE A 130
 None
 0.62A 2dg9A-4r0xA:
18.9		 2dg9A-4r0xA:
44.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r0x PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		6 TYR A  57
PHE A  77
VAL A  86
ILE A  87
TYR A 113
PHE A 130
 None
 0.58A 2dg9A-4r0xA:
18.9		 2dg9A-4r0xA:
44.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ric FANCONI-ASSOCIATED
NUCLEASE 1

(Homo sapiens) 		PF08774
(VRR_NUC) 		5 TYR A 436
VAL A 446
ILE A 447
LEU A 443
ILE A 537
 None
 1.12A 2dg9A-4ricA:
undetectable		 2dg9A-4ricA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4trq NUCLEAR MRNA EXPORT
PROTEIN SAC3
NUCLEAR MRNA EXPORT
PROTEIN THP1

(Saccharomyces
cerevisiae) 		PF01399
(PCI)
PF03399
(SAC3_GANP) 		5 GLU B 336
ILE B 390
LEU A 400
TYR B 391
PHE A 391
 None
 0.98A 2dg9A-4trqB:
undetectable		 2dg9A-4trqB:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xnu INTEGRAL MEMBRANE
PROTEIN-DOPAMINE
TRANSPORTER

(Drosophila
melanogaster) 		PF00209
(SNF) 		5 GLU A 161
VAL A 381
ILE A 378
LEU A 367
PHE A 364
 None
 1.16A 2dg9A-4xnuA:
undetectable		 2dg9A-4xnuA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b6h ADENINE
PHOSPHORIBOSYLTRANSF
ERASE

(Yersinia
pseudotuberculosis) 		PF00156
(Pribosyltran) 		5 ASP A 131
VAL A  78
ILE A  49
LEU A  52
TYR A  45
 AMP  A 501 ( 2.8A)
None
None
None
None
 1.08A 2dg9A-5b6hA:
undetectable		 2dg9A-5b6hA:
25.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b86 TUMOR NECROSIS
FACTOR ALPHA-INDUCED
PROTEIN 2

(Mus musculus) 		PF06046
(Sec6) 		5 TYR A 600
VAL A 522
ILE A 526
ILE A 580
PHE A 644
 None
 1.17A 2dg9A-5b86A:
undetectable		 2dg9A-5b86A:
10.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5b8i PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Coccidioides
immitis) 		PF00254
(FKBP_C) 		7 TYR C  36
ASP C  56
PHE C  64
VAL C  73
ILE C  74
TYR C 100
PHE C 117
 FK5  C 201 (-4.1A)
FK5  C 201 ( 3.8A)
FK5  C 201 (-3.8A)
FK5  C 201 (-3.5A)
FK5  C 201 (-3.8A)
FK5  C 201 (-4.5A)
FK5  C 201 (-4.7A)
 0.46A 2dg9A-5b8iC:
19.6		 2dg9A-5b8iC:
42.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dm4 METHYLTRANSFERASE
DOMAIN FAMILY

(Bacillus
pumilus) 		PF13489
(Methyltransf_23) 		5 ASP A  65
ILE A 104
LEU A 102
ILE A  63
PHE A 108
 SAH  A 300 ( 4.4A)
None
None
None
None
 1.07A 2dg9A-5dm4A:
undetectable		 2dg9A-5dm4A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF09334
(tRNA-synt_1g) 		5 ASP A 605
ILE A 284
LEU A 281
HIS A 340
ILE A 339
 None
 1.17A 2dg9A-5gl7A:
undetectable		 2dg9A-5gl7A:
13.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i7p PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A,FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A

(Escherichia
coli;
Homo sapiens) 		PF00254
(FKBP_C) 		7 ASP A  37
GLU A  54
VAL A  55
ILE A  56
TYR A  82
HIS A 137
PHE A 146
 None
 1.06A 2dg9A-5i7pA:
20.2		 2dg9A-5i7pA:
62.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i7p PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A,FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A

(Escherichia
coli;
Homo sapiens) 		PF00254
(FKBP_C) 		8 TYR A  26
ASP A  37
PHE A  46
GLU A  54
VAL A  55
ILE A  56
TYR A  82
PHE A 146
 None
 0.66A 2dg9A-5i7pA:
20.2		 2dg9A-5i7pA:
62.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i7q PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A,FKBP-TYPE 16
KDA PEPTIDYL-PROLYL
CIS-TRANS
ISOMERASE,PEPTIDYL-P
ROLYL CIS-TRANS
ISOMERASE FKBP1A

(Escherichia
coli;
Homo sapiens) 		PF00254
(FKBP_C) 		9 TYR A  26
ASP A  37
PHE A  46
GLU A  54
VAL A  55
ILE A  56
TYR A  82
HIS A 138
PHE A 147
 None
 0.94A 2dg9A-5i7qA:
20.2		 2dg9A-5i7qA:
65.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i98 FK506-BINDING
PROTEIN 1

(Candida
albicans) 		PF00254
(FKBP_C) 		8 TYR A  30
ASP A  41
PHE A  50
VAL A  59
ILE A  60
TYR A  97
ILE A 105
PHE A 114
 None
 0.54A 2dg9A-5i98A:
18.8		 2dg9A-5i98A:
45.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5i98 FK506-BINDING
PROTEIN 1

(Candida
albicans) 		PF00254
(FKBP_C) 		6 TYR A  30
ASP A  41
PHE A  50
VAL A  59
ILE A 102
PHE A 114
 None
 1.14A 2dg9A-5i98A:
18.8		 2dg9A-5i98A:
45.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ij6 LIPOATE--PROTEIN
LIGASE

(Enterococcus
faecalis) 		PF03099
(BPL_LplA_LipB)
PF10437
(Lip_prot_lig_C) 		5 PHE A 317
GLU A 295
ILE A 283
ILE A 278
PHE A 331
 None
 1.05A 2dg9A-5ij6A:
undetectable		 2dg9A-5ij6A:
16.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j6e FK506-BINDING
PROTEIN 1A

(Aspergillus
fumigatus) 		PF00254
(FKBP_C) 		7 TYR A  27
ASP A  38
PHE A  47
VAL A  56
ILE A  57
TYR A  83
PHE A 100
 None
 0.56A 2dg9A-5j6eA:
20.5		 2dg9A-5j6eA:
56.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j6e FK506-BINDING
PROTEIN 1A

(Aspergillus
fumigatus) 		PF00254
(FKBP_C) 		5 TYR A  27
ASP A  38
PHE A  47
VAL A  56
ILE A  92
 None
 1.06A 2dg9A-5j6eA:
20.5		 2dg9A-5j6eA:
56.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j9r CHOLOYLGLYCINE
HYDROLASE

(Agrobacterium
tumefaciens) 		PF02275
(CBAH) 		5 ILE A 126
LEU A  96
TYR A 156
ILE A 163
PHE A 124
 None
 1.12A 2dg9A-5j9rA:
undetectable		 2dg9A-5j9rA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n81 TYROCIDINE SYNTHASE
1

(Brevibacillus
parabrevis) 		no annotation 5 VAL A 101
ILE A 104
TYR A 114
ILE A 186
PHE A 240
 None
 1.12A 2dg9A-5n81A:
undetectable		 2dg9A-5n81A:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olk RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE,
BETA SUBUNIT 1

(Leeuwenhoekiella
blandensis) 		no annotation 5 GLU A 390
VAL A 359
ILE A 360
ILE A 274
PHE A 347
 None
 1.10A 2dg9A-5olkA:
undetectable		 2dg9A-5olkA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8t UBIQUITIN-LIKE
PROTEIN
SMT3,PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Burkholderia
pseudomallei;
Saccharomyces
cerevisiae) 		no annotation 7 TYR A  33
ASP A  44
PHE A  53
VAL A  62
ILE A  63
TYR A  89
PHE A 106
 8ZV  A 201 (-3.8A)
8ZV  A 201 (-3.9A)
8ZV  A 201 (-3.9A)
8ZV  A 201 (-3.6A)
8ZV  A 201 (-4.0A)
8ZV  A 201 (-4.6A)
8ZV  A 201 (-4.6A)
 0.34A 2dg9A-5v8tA:
18.6		 2dg9A-5v8tA:
25.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xb0 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF00254
(FKBP_C) 		6 TYR A 147
ASP A 158
PHE A 166
ILE A 172
TYR A 198
PHE A 215
 TLA  A 301 ( 4.4A)
TLA  A 301 (-3.7A)
TLA  A 301 ( 4.6A)
TLA  A 301 (-3.4A)
None
None
 1.18A 2dg9A-5xb0A:
15.0		 2dg9A-5xb0A:
31.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xb0 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Pseudomonas
syringae group
genomosp. 3) 		PF00254
(FKBP_C) 		6 TYR A 147
ASP A 158
VAL A 171
ILE A 172
TYR A 198
PHE A 215
 TLA  A 301 ( 4.4A)
TLA  A 301 (-3.7A)
TLA  A 301 (-3.4A)
TLA  A 301 (-3.4A)
None
None
 0.72A 2dg9A-5xb0A:
15.0		 2dg9A-5xb0A:
31.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbq PEROXIREDOXIN

(Pyrococcus
horikoshii) 		no annotation 5 VAL A  13
ILE A  20
LEU A  22
HIS A  17
PHE A  26
 None
 1.13A 2dg9A-5xbqA:
undetectable		 2dg9A-5xbqA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2

(Saccharomyces
cerevisiae) 		no annotation 5 GLU B 181
VAL B 180
ILE B 158
LEU B 160
ILE B 107
 None
 1.20A 2dg9A-5y58B:
undetectable		 2dg9A-5y58B:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y59 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2

(Saccharomyces
cerevisiae) 		no annotation 5 GLU B 181
VAL B 180
ILE B 158
LEU B 160
ILE B 107
 None
 1.05A 2dg9A-5y59B:
undetectable		 2dg9A-5y59B:
20.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6b4p PEPTIDYLPROLYL
ISOMERASE

(Naegleria
fowleri) 		no annotation 7 ASP A  49
PHE A  58
GLU A  66
VAL A  67
ILE A  68
TYR A  94
PHE A 111
 None
 0.78A 2dg9A-6b4pA:
19.2		 2dg9A-6b4pA:
40.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6b4p PEPTIDYLPROLYL
ISOMERASE

(Naegleria
fowleri) 		no annotation 5 ASP A  49
PHE A  58
GLU A  66
VAL A  67
ILE A 103
 None
 1.19A 2dg9A-6b4pA:
19.2		 2dg9A-6b4pA:
40.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6b4p PEPTIDYLPROLYL
ISOMERASE

(Naegleria
fowleri) 		no annotation 7 TYR A  38
ASP A  49
PHE A  58
VAL A  67
ILE A  68
TYR A  94
PHE A 111
 None
 0.54A 2dg9A-6b4pA:
19.2		 2dg9A-6b4pA:
40.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6b4p PEPTIDYLPROLYL
ISOMERASE

(Naegleria
fowleri) 		no annotation 5 TYR A  38
ASP A  49
PHE A  58
VAL A  67
ILE A 103
 None
 1.08A 2dg9A-6b4pA:
19.2		 2dg9A-6b4pA:
40.94