SIMILAR PATTERNS OF AMINO ACIDS FOR 2DDW_A_PXLA1003_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cn3 COAT PROTEIN VP1

(Polyomavirus
sp.) 		PF00718
(Polyoma_coat) 		4 VAL A 283
LEU A 172
PRO A 229
ASP A 284
 None
 0.89A 2ddwA-1cn3A:
undetectable		 2ddwA-1cn3A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fn4 MONOCLONAL ANTIBODY
AGAINST
ACETYLCHOLINE
RECEPTOR

(Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 SER B 112
VAL B 114
VAL B 190
TYR B 138
 None
 1.05A 2ddwA-1fn4B:
undetectable		 2ddwA-1fn4B:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hg3 TRIOSEPHOSPHATE
ISOMERASE

(Pyrococcus
woesei) 		PF00121
(TIM)
PF05690
(ThiG) 		4 VAL A 170
VAL A 179
LEU A 169
PRO A 127
 None
 0.92A 2ddwA-1hg3A:
undetectable		 2ddwA-1hg3A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kp0 CREATINE
AMIDINOHYDROLASE

(Actinobacillus) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		4 VAL A  43
VAL A 147
HIS A  49
ASP A 146
 None
 1.08A 2ddwA-1kp0A:
undetectable		 2ddwA-1kp0A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lqw PEPTIDE DEFORMYLASE
PDF1

(Staphylococcus
aureus) 		PF01327
(Pep_deformylase) 		4 VAL A  75
VAL A 151
LEU A  76
PRO A  78
 None
 1.04A 2ddwA-1lqwA:
undetectable		 2ddwA-1lqwA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1psq PROBABLE THIOL
PEROXIDASE

(Streptococcus
pneumoniae) 		PF08534
(Redoxin) 		4 VAL A   2
LEU A 117
TYR A 143
ASP A 145
 None
 1.06A 2ddwA-1psqA:
undetectable		 2ddwA-1psqA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qnr ENDO-1,4-B-D-MANNANA
SE

(Trichoderma
reesei) 		PF00150
(Cellulase) 		4 VAL A  52
LEU A 106
HIS A 198
ASP A  15
 None
 1.01A 2ddwA-1qnrA:
undetectable		 2ddwA-1qnrA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rfv PYRIDOXAL KINASE

(Ovis aries) 		PF08543
(Phos_pyr_kin) 		4 SER A  12
VAL A  14
VAL A  19
ASP A 235
 None
 0.51A 2ddwA-1rfvA:
30.6		 2ddwA-1rfvA:
29.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1td2 PYRIDOXAMINE KINASE

(Escherichia
coli) 		PF08543
(Phos_pyr_kin) 		4 SER A  10
VAL A  12
TYR A  83
ASP A 224
 PXL  A 288 (-2.4A)
None
PXL  A 288 (-3.8A)
PXL  A 288 (-2.5A)
 0.47A 2ddwA-1td2A:
31.5		 2ddwA-1td2A:
28.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ub7 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
SYNTHASE

(Thermus
thermophilus) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 VAL A 163
VAL A  72
LEU A   5
ASP A  73
 None
 1.08A 2ddwA-1ub7A:
undetectable		 2ddwA-1ub7A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uw4 REGULATOR OF
NONSENSE TRANSCRIPTS
2

(Homo sapiens) 		PF02854
(MIF4G) 		4 VAL B 775
VAL B 809
LEU B 771
PRO B 799
 None
 1.01A 2ddwA-1uw4B:
undetectable		 2ddwA-1uw4B:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uz5 402AA LONG
HYPOTHETICAL
MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN

(Pyrococcus
horikoshii) 		PF00994
(MoCF_biosynth)
PF03453
(MoeA_N)
PF03454
(MoeA_C) 		4 VAL A 379
VAL A 394
LEU A 350
PRO A 361
 None
 0.82A 2ddwA-1uz5A:
undetectable		 2ddwA-1uz5A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE

(Thermotoga
maritima) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 SER A 239
VAL A 170
VAL A 150
HIS A 206
 None
 0.77A 2ddwA-1vknA:
3.7		 2ddwA-1vknA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vma CELL DIVISION
PROTEIN FTSY

(Thermotoga
maritima) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		4 VAL A 123
VAL A 117
LEU A 125
ASP A 118
 None
 1.03A 2ddwA-1vmaA:
undetectable		 2ddwA-1vmaA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w0m TRIOSEPHOSPHATE
ISOMERASE

(Thermoproteus
tenax) 		PF00121
(TIM)
PF05690
(ThiG) 		4 VAL A 167
VAL A 176
LEU A 166
PRO A 124
 None
 0.89A 2ddwA-1w0mA:
undetectable		 2ddwA-1w0mA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xip NUCLEOPORIN NUP159

(Saccharomyces
cerevisiae) 		PF16755
(NUP214) 		4 VAL A 139
VAL A 169
LEU A 138
ASP A 168
 None
 1.06A 2ddwA-1xipA:
undetectable		 2ddwA-1xipA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8a HYPOTHETICAL PROTEIN
AF1437

(Archaeoglobus
fulgidus) 		no annotation 4 SER A 293
VAL A 289
VAL A 241
LEU A 290
 None
 0.84A 2ddwA-1y8aA:
undetectable		 2ddwA-1y8aA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yad REGULATORY PROTEIN
TENI

(Bacillus
subtilis) 		PF02581
(TMP-TENI) 		4 VAL A  76
VAL A  65
PRO A  79
ASP A  66
 None
None
144  A 300 ( 3.3A)
None
 0.89A 2ddwA-1yadA:
undetectable		 2ddwA-1yadA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cou ECT2 PROTEIN

(Mus musculus) 		PF00533
(BRCT) 		4 VAL A  55
VAL A  73
LEU A  21
PRO A  64
 None
 1.07A 2ddwA-2couA:
undetectable		 2ddwA-2couA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e1m L-GLUTAMATE OXIDASE

(Streptomyces
sp. X-119-6) 		PF01593
(Amino_oxidase) 		4 VAL A  72
VAL C 658
LEU A  71
PRO A 337
 None
 0.94A 2ddwA-2e1mA:
undetectable		 2ddwA-2e1mA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e9y CARBAMATE KINASE

(Aeropyrum
pernix) 		PF00696
(AA_kinase) 		4 VAL A 241
VAL A 279
LEU A 253
TYR A 264
 None
 1.02A 2ddwA-2e9yA:
undetectable		 2ddwA-2e9yA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gre DEBLOCKING
AMINOPEPTIDASE

(Bacillus cereus) 		PF05343
(Peptidase_M42) 		4 VAL A 191
VAL A  70
LEU A 194
ASP A  71
 None
 0.94A 2ddwA-2greA:
undetectable		 2ddwA-2greA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2imr HYPOTHETICAL PROTEIN
DR_0824

(Deinococcus
radiodurans) 		PF01979
(Amidohydro_1) 		4 VAL A 174
VAL A 185
LEU A 175
PRO A 177
 None
 1.05A 2ddwA-2imrA:
undetectable		 2ddwA-2imrA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7n RNA-DEPENDENT RNA
POLYMERASE

(Neurospora
crassa) 		PF05183
(RdRP) 		4 VAL A 929
PRO A 980
HIS A 983
ASP A 751
 None
 1.01A 2ddwA-2j7nA:
undetectable		 2ddwA-2j7nA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ouc DUAL SPECIFICITY
PROTEIN PHOSPHATASE
10

(Homo sapiens) 		PF00581
(Rhodanese) 		4 VAL A 212
VAL A 255
LEU A 215
HIS A 193
 None
 0.79A 2ddwA-2oucA:
undetectable		 2ddwA-2oucA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2own PUTATIVE
OLEOYL-[ACYL-CARRIER
PROTEIN]
THIOESTERASE

(Lactobacillus
plantarum) 		PF01643
(Acyl-ACP_TE) 		4 VAL A 212
VAL A 241
HIS A 166
ASP A 242
 None
None
SO4  A 262 (-4.1A)
None
 0.99A 2ddwA-2ownA:
undetectable		 2ddwA-2ownA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ps3 HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA

(Escherichia
coli) 		PF01297
(ZnuA) 		4 SER A  31
VAL A  35
VAL A  81
HIS A 143
 None
 0.86A 2ddwA-2ps3A:
undetectable		 2ddwA-2ps3A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qf7 PYRUVATE CARBOXYLASE
PROTEIN

(Rhizobium etli) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 SER A 238
VAL A 217
PRO A 253
TYR A 452
 None
 0.86A 2ddwA-2qf7A:
undetectable		 2ddwA-2qf7A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vda TRANSLOCASE SUBUNIT
SECA

(Escherichia
coli) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		4 VAL A 208
VAL A 211
LEU A 207
ASP A 212
 None
 0.85A 2ddwA-2vdaA:
undetectable		 2ddwA-2vdaA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w9x PUTATIVE ACETYL
XYLAN ESTERASE

(Cellvibrio
japonicus) 		PF00657
(Lipase_GDSL) 		4 SER A 294
LEU A 328
PRO A 337
HIS A 336
 None
None
None
GOL  A1362 (-4.5A)
 0.94A 2ddwA-2w9xA:
4.2		 2ddwA-2w9xA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xa0 APOPTOSIS REGULATOR
BCL-2

(Homo sapiens) 		PF00452
(Bcl-2)
PF02180
(BH4) 		4 VAL A 162
VAL A 170
HIS A  20
ASP A 171
 None
 1.01A 2ddwA-2xa0A:
undetectable		 2ddwA-2xa0A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsz RUVB-LIKE 1

(Homo sapiens) 		PF06068
(TIP49) 		4 VAL A 269
LEU A 263
PRO A 258
HIS A 259
 None
 0.91A 2ddwA-2xszA:
undetectable		 2ddwA-2xszA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7c TYPE-1 RESTRICTION
ENZYME ECOKI
SPECIFICITY PROTEIN

(Escherichia
coli) 		PF01420
(Methylase_S) 		4 VAL A 263
VAL A 258
LEU A 306
TYR A 316
 None
 0.92A 2ddwA-2y7cA:
undetectable		 2ddwA-2y7cA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yia RNA-DIRECTED RNA
POLYMERASE

(Infectious
pancreatic
necrosis virus) 		PF04197
(Birna_RdRp) 		4 SER A 269
VAL A 265
LEU A 266
PRO A  96
 None
 0.93A 2ddwA-2yiaA:
undetectable		 2ddwA-2yiaA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yib RNA-DIRECTED RNA
POLYMERASE

(Infectious
pancreatic
necrosis virus) 		PF04197
(Birna_RdRp) 		4 SER D 269
VAL D 265
LEU D 266
PRO D  96
 None
 0.91A 2ddwA-2yibD:
undetectable		 2ddwA-2yibD:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3act CELLOBIOSE
PHOSPHORYLASE

(Cellulomonas
gilvus) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 VAL A 807
VAL A 797
LEU A 755
ASP A 798
 None
 1.00A 2ddwA-3actA:
undetectable		 2ddwA-3actA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3azq AMINOPEPTIDASE

(Streptomyces
morookaense) 		PF00326
(Peptidase_S9) 		4 SER A 519
LEU A 537
PRO A 535
ASP A 483
 None
 0.95A 2ddwA-3azqA:
undetectable		 2ddwA-3azqA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3beo UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Bacillus
anthracis) 		PF02350
(Epimerase_2) 		4 VAL A  24
VAL A  38
LEU A  25
ASP A  60
 None
 0.96A 2ddwA-3beoA:
3.7		 2ddwA-3beoA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3by9 SENSOR PROTEIN

(Vibrio cholerae) 		PF02743
(dCache_1) 		4 VAL A 201
VAL A 193
LEU A 210
PRO A 207
 None
 1.08A 2ddwA-3by9A:
undetectable		 2ddwA-3by9A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c18 NUCLEOTIDYLTRANSFERA
SE-LIKE PROTEIN

(Exiguobacterium
sibiricum) 		PF14540
(NTF-like) 		4 VAL A 164
VAL A 175
LEU A 165
HIS A 158
 None
 0.79A 2ddwA-3c18A:
undetectable		 2ddwA-3c18A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8) 		4 VAL A 312
VAL A 336
LEU A 286
HIS A 391
 None
 0.99A 2ddwA-3gcwA:
3.0		 2ddwA-3gcwA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gfo COBALT IMPORT
ATP-BINDING PROTEIN
CBIO 1

(Clostridium
perfringens) 		PF00005
(ABC_tran) 		4 VAL A 157
VAL A 104
LEU A 156
ASP A 103
 None
 0.92A 2ddwA-3gfoA:
undetectable		 2ddwA-3gfoA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ghf SEPTUM
SITE-DETERMINING
PROTEIN MINC

(Salmonella
enterica) 		PF05209
(MinC_N) 		4 VAL A  52
VAL A  78
LEU A  20
HIS A  65
 None
 0.98A 2ddwA-3ghfA:
undetectable		 2ddwA-3ghfA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gse MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE

(Yersinia pestis) 		PF00425
(Chorismate_bind) 		4 VAL A 307
LEU A 337
PRO A 326
ASP A 308
 None
 0.63A 2ddwA-3gseA:
undetectable		 2ddwA-3gseA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h8z FRAGILE X MENTAL
RETARDATION
SYNDROME-RELATED
PROTEIN 2

(Homo sapiens) 		PF05641
(Agenet) 		4 VAL A  31
VAL A  34
LEU A  15
TYR A  11
 None
 0.96A 2ddwA-3h8zA:
undetectable		 2ddwA-3h8zA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvn HEMOLYSIN

(Streptococcus
suis) 		PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C) 		4 VAL A 263
LEU A 103
PRO A 114
TYR A 359
 None
 0.96A 2ddwA-3hvnA:
undetectable		 2ddwA-3hvnA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldr FRUCTOSYLTRANSFERASE

(Aspergillus
japonicus) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 VAL A 202
VAL A 221
LEU A 203
ASP A 222
 None
 1.05A 2ddwA-3ldrA:
undetectable		 2ddwA-3ldrA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3le2 SERPIN-ZX

(Arabidopsis
thaliana) 		PF00079
(Serpin) 		4 VAL A 291
VAL A  21
LEU A 292
HIS A 327
 None
 0.67A 2ddwA-3le2A:
undetectable		 2ddwA-3le2A:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pbl D(3) DOPAMINE
RECEPTOR, LYSOZYME
CHIMERA

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 SER A 192
VAL A 111
PRO A 167
TYR A 191
 ETQ  A1200 (-3.3A)
ETQ  A1200 (-3.4A)
None
None
 1.08A 2ddwA-3pblA:
undetectable		 2ddwA-3pblA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI

(Mycobacterium
tuberculosis) 		PF00425
(Chorismate_bind) 		4 VAL A  64
VAL A  96
LEU A  66
ASP A  97
 None
 1.03A 2ddwA-3rv6A:
undetectable		 2ddwA-3rv6A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slu M23 PEPTIDASE DOMAIN
PROTEIN

(Neisseria
meningitidis) 		PF01551
(Peptidase_M23) 		4 VAL A  77
VAL A  68
LEU A  78
HIS A 103
 None
 1.02A 2ddwA-3sluA:
undetectable		 2ddwA-3sluA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umg HALOACID
DEHALOGENASE

(Rhodococcus
jostii) 		PF00702
(Hydrolase) 		4 VAL A  51
PRO A 220
HIS A 221
ASP A  49
 None
 1.06A 2ddwA-3umgA:
2.1		 2ddwA-3umgA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x3y PHENYLETHYLAMINE
OXIDASE

(Arthrobacter
globiformis) 		PF01179
(Cu_amine_oxid)
PF02728
(Cu_amine_oxidN3) 		4 VAL A 182
LEU A  98
PRO A  72
ASP A 180
 None
 0.98A 2ddwA-3x3yA:
undetectable		 2ddwA-3x3yA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zs7 PYRIDOXAL KINASE

(Trypanosoma
brucei) 		PF08543
(Phos_pyr_kin) 		4 SER A  11
VAL A  13
VAL A  18
TYR A  84
 None
 0.75A 2ddwA-3zs7A:
30.4		 2ddwA-3zs7A:
29.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zs7 PYRIDOXAL KINASE

(Trypanosoma
brucei) 		PF08543
(Phos_pyr_kin) 		4 VAL A  13
VAL A  18
LEU A  42
ASP A 229
 None
None
None
ATP  A1301 ( 4.5A)
 0.36A 2ddwA-3zs7A:
30.4		 2ddwA-3zs7A:
29.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zs7 PYRIDOXAL KINASE

(Trypanosoma
brucei) 		PF08543
(Phos_pyr_kin) 		4 VAL A  13
VAL A  18
TYR A  84
ASP A 229
 None
None
None
ATP  A1301 ( 4.5A)
 0.34A 2ddwA-3zs7A:
30.4		 2ddwA-3zs7A:
29.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00940
(RNA_pol)
PF14700
(RPOL_N) 		4 VAL A 717
VAL A 820
LEU A 720
ASP A 819
 None
 1.01A 2ddwA-4bocA:
undetectable		 2ddwA-4bocA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crn ERF3 IN RIBOSOME
BOUND
ERF1-ERF3-GDPNP
COMPLEX

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		4 VAL P 367
LEU P 366
HIS P 388
ASP P 269
 None
 1.08A 2ddwA-4crnP:
undetectable		 2ddwA-4crnP:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e5t MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME, C-TERMINAL
DOMAIN PROTEIN

(Labrenzia
alexandrii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 SER A 193
LEU A 190
PRO A 185
HIS A 183
 None
 1.06A 2ddwA-4e5tA:
undetectable		 2ddwA-4e5tA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fkz UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Bacillus
subtilis) 		PF02350
(Epimerase_2) 		4 VAL A  23
VAL A  36
LEU A  24
ASP A  58
 None
 0.93A 2ddwA-4fkzA:
5.8		 2ddwA-4fkzA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ftd UNCHARACTERIZED
PROTEIN

(Bacteroides
eggerthii) 		PF15416
(DUF4623) 		4 VAL A 223
LEU A 225
PRO A 183
HIS A 184
 None
 1.06A 2ddwA-4ftdA:
undetectable		 2ddwA-4ftdA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1g MATRIX PROTEIN

(Avian
avulavirus 1) 		PF00661
(Matrix) 		4 VAL A 186
VAL A 181
HIS A 354
ASP A  55
 None
 0.93A 2ddwA-4g1gA:
undetectable		 2ddwA-4g1gA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jem CMP/HYDROXYMETHYL
CMP HYDROLASE

(Streptomyces
rimofaciens) 		PF05014
(Nuc_deoxyrib_tr) 		4 VAL A 115
VAL A 156
LEU A 140
HIS A  47
 None
 1.04A 2ddwA-4jemA:
3.3		 2ddwA-4jemA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ke4 HYDROXYCINNAMOYL-COA
:SHIKIMATE
HYDROXYCINNAMOYL
TRANSFERASE

(Sorghum bicolor) 		PF02458
(Transferase) 		4 VAL A 317
LEU A 196
PRO A 310
ASP A 166
 None
 0.94A 2ddwA-4ke4A:
undetectable		 2ddwA-4ke4A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kw7 ARSENIC
METHYLTRANSFERASE

(Cyanidioschyzon
sp. 5508) 		PF13847
(Methyltransf_31) 		4 SER A 166
VAL A 192
VAL A 162
LEU A 193
 None
 1.04A 2ddwA-4kw7A:
undetectable		 2ddwA-4kw7A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lc9 GLUCOKINASE
REGULATORY PROTEIN

(Rattus
norvegicus) 		no annotation 4 VAL A  93
VAL A 174
LEU A  94
TYR A 134
 None
 0.94A 2ddwA-4lc9A:
2.6		 2ddwA-4lc9A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg9 F-BOX-LIKE/WD
REPEAT-CONTAINING
PROTEIN TBL1XR1

(Homo sapiens) 		PF00400
(WD40) 		4 VAL A 498
VAL A 489
LEU A 510
HIS A 467
 None
 1.00A 2ddwA-4lg9A:
undetectable		 2ddwA-4lg9A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mhc NUCLEOPORIN NUP157

(Saccharomyces
cerevisiae) 		PF08801
(Nucleoporin_N) 		4 VAL A 620
LEU A 624
PRO A 630
HIS A 633
 None
 0.95A 2ddwA-4mhcA:
undetectable		 2ddwA-4mhcA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8) 		4 VAL B 312
VAL B 336
LEU B 286
HIS B 391
 None
 1.01A 2ddwA-4ov6B:
5.9		 2ddwA-4ov6B:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT

(Aquincola
tertiaricarbonis) 		PF01642
(MM_CoA_mutase) 		4 VAL A 299
VAL A 411
LEU A 359
PRO A 404
 None
 0.97A 2ddwA-4r3uA:
2.3		 2ddwA-4r3uA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1i PYRIDOXAL KINASE

(Entamoeba
histolytica) 		PF08543
(Phos_pyr_kin) 		6 SER B  10
VAL B  12
VAL B  17
LEU B  41
TYR B  83
ASP B 218
 PLP  B 302 (-2.4A)
None
PLP  B 302 (-4.4A)
PLP  B 302 (-4.9A)
PLP  B 302 (-3.8A)
PLP  B 302 (-3.5A)
 0.54A 2ddwA-4s1iB:
33.1		 2ddwA-4s1iB:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txk PROTEIN-METHIONINE
SULFOXIDE OXIDASE
MICAL1

(Mus musculus) 		PF00307
(CH)
PF01494
(FAD_binding_3) 		4 VAL A 101
VAL A 167
LEU A 105
TYR A  48
 None
 0.97A 2ddwA-4txkA:
undetectable		 2ddwA-4txkA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4up7 LYSINE--TRNA LIGASE

(Entamoeba
histolytica) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 SER A  31
VAL A  56
PRO A 116
HIS A 115
 None
 1.07A 2ddwA-4up7A:
2.2		 2ddwA-4up7A:
16.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wy9 PUTATIVE MCP-TYPE
SIGNAL TRANSDUCTION
PROTEIN

(Campylobacter
jejuni) 		PF02743
(dCache_1) 		4 SER A 319
LEU A 324
TYR A 318
ASP A 293
 None
 0.98A 2ddwA-4wy9A:
undetectable		 2ddwA-4wy9A:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zm4 AMINOTRANSFERASE

(Streptomyces
pactum) 		PF00202
(Aminotran_3) 		4 VAL A 154
LEU A 155
TYR A 147
ASP A 248
 None
None
PLP  A 501 (-4.6A)
PLP  A 501 (-2.8A)
 0.79A 2ddwA-4zm4A:
undetectable		 2ddwA-4zm4A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		4 VAL A 123
VAL A 119
LEU A 154
ASP A 120
 None
 0.94A 2ddwA-5a31A:
undetectable		 2ddwA-5a31A:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c1i TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI

(Thermus
thermophilus) 		PF08704
(GCD14) 		4 VAL A 247
VAL A 201
LEU A 246
HIS A 242
 None
 1.06A 2ddwA-5c1iA:
2.9		 2ddwA-5c1iA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5doo PROTEIN LYSINE
METHYLTRANSFERASE 2

(Rickettsia
typhi) 		PF10119
(MethyTransf_Reg)
PF13847
(Methyltransf_31) 		4 SER A  68
VAL A  47
PRO A  26
TYR A  65
 None
 1.06A 2ddwA-5dooA:
2.3		 2ddwA-5dooA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5imt INTERMEDILYSIN

(Streptococcus
intermedius) 		PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C) 		4 VAL A 293
LEU A 134
PRO A 145
TYR A 389
 None
 1.08A 2ddwA-5imtA:
undetectable		 2ddwA-5imtA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5imw INTERMEDILYSIN

(Streptococcus
intermedius) 		PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C) 		4 VAL A 293
LEU A 134
PRO A 145
TYR A 389
 None
 1.08A 2ddwA-5imwA:
undetectable		 2ddwA-5imwA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jq9 DIHYDROPTEROATE
SYNTHASE

(Yersinia pestis) 		PF00809
(Pterin_bind) 		4 SER A 106
VAL A  78
VAL A  95
LEU A  75
 None
 0.94A 2ddwA-5jq9A:
2.9		 2ddwA-5jq9A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kjv HYDROXYCINNAMOYL
TRANSFERASE

(Plectranthus
scutellarioides) 		PF02458
(Transferase) 		4 VAL A 295
LEU A 187
PRO A 288
ASP A 157
 None
 0.91A 2ddwA-5kjvA:
undetectable		 2ddwA-5kjvA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcw ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		4 VAL A 123
VAL A 119
LEU A 154
ASP A 120
 None
 1.02A 2ddwA-5lcwA:
undetectable		 2ddwA-5lcwA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lgg ANAPHASE-PROMOTING
COMPLEX SUBUNIT
1,ANAPHASE-PROMOTING
COMPLEX SUBUNIT
1,ANAPHASE-PROMOTING
COMPLEX SUBUNIT
1,ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		4 VAL A 123
VAL A 119
LEU A 154
ASP A 120
 None
 1.04A 2ddwA-5lggA:
undetectable		 2ddwA-5lggA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkk MULTIDRUG RESISTANCE
ABC TRANSPORTER
ATP-BINDING AND
PERMEASE PROTEIN

(Thermus
thermophilus) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 VAL A 358
VAL A 417
LEU A 360
ASP A 423
 None
 0.86A 2ddwA-5mkkA:
undetectable		 2ddwA-5mkkA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oom ACYL CARRIER
PROTEIN,
MITOCHONDRIAL

(Homo sapiens) 		PF01016
(Ribosomal_L27) 		4 VAL w  83
VAL w 145
LEU w  84
ASP w 146
 None
 1.03A 2ddwA-5oomw:
undetectable		 2ddwA-5oomw:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thm ESTERASE-6

(Drosophila
melanogaster) 		PF00135
(COesterase) 		4 VAL A 432
VAL A 457
LEU A 433
HIS A 445
 None
None
None
7BZ  A 601 (-3.8A)
 1.08A 2ddwA-5thmA:
undetectable		 2ddwA-5thmA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uki RNA LARIAT
DEBRANCHING ENZYME,
PUTATIVE

(Entamoeba
histolytica) 		no annotation 4 SER A 177
VAL A 129
LEU A 218
PRO A 183
 None
 1.01A 2ddwA-5ukiA:
undetectable		 2ddwA-5ukiA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v57 SMOOTHENED
HOMOLOG,FLAVODOXIN,S
MOOTHENED HOMOLOG

(Desulfovibrio
vulgaris;
Homo sapiens) 		PF00258
(Flavodoxin_1)
PF01392
(Fz)
PF01534
(Frizzled) 		4 VAL A 411
VAL A 329
LEU A 412
HIS A 470
 None
None
None
836  A1201 ( 4.9A)
 0.96A 2ddwA-5v57A:
3.5		 2ddwA-5v57A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vkq NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L

(Drosophila
melanogaster) 		PF00023
(Ank)
PF00520
(Ion_trans)
PF12796
(Ank_2)
PF13637
(Ank_4) 		4 VAL A 878
LEU A 882
PRO A 866
HIS A 832
 None
 1.02A 2ddwA-5vkqA:
undetectable		 2ddwA-5vkqA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vkt CINNAMYL ALCOHOL
DEHYDROGENASES
(SBCAD4)

(Sorghum bicolor) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 VAL A 151
VAL A  72
LEU A 155
PRO A 156
 None
 0.93A 2ddwA-5vktA:
3.4		 2ddwA-5vktA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlh PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8)
PF05922
(Inhibitor_I9) 		4 VAL A 312
VAL A 336
LEU A 286
HIS A 391
 None
 1.00A 2ddwA-5vlhA:
4.6		 2ddwA-5vlhA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vni PROTEIN TRANSPORT
PROTEIN SEC24A

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 VAL B 903
VAL B 871
LEU B 907
HIS B1086
 None
 0.95A 2ddwA-5vniB:
3.3		 2ddwA-5vniB:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9q PUTATIVE
CYTIDYLYLTRANSFERASE

(Burkholderia
pseudomallei) 		no annotation 4 VAL A  91
VAL A  56
LEU A  88
HIS A  40
 None
 0.93A 2ddwA-5x9qA:
2.7		 2ddwA-5x9qA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgu RIBONUCLEASE R

(Escherichia
coli) 		no annotation 4 VAL B 544
VAL B 138
LEU B 548
ASP B 139
 None
 0.91A 2ddwA-5xguB:
undetectable		 2ddwA-5xguB:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmm BETA-2-MICROGLOBULIN
MHC CLASS I ANTIGEN
ALPHA CHAIN

(Felis catus) 		no annotation 4 SER A  93
VAL A  13
PRO B  33
HIS B  32
 None
 1.03A 2ddwA-5xmmA:
undetectable		 2ddwA-5xmmA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxa NON-STRUCTURAL
PROTEIN 1

(Yellow fever
virus) 		no annotation 4 SER A 155
VAL A 100
LEU A 102
PRO A  96
 None
 1.03A 2ddwA-5yxaA:
undetectable		 2ddwA-5yxaA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d ATP SYNTHASE ALPHA
CHAIN, MITOCHONDRIAL

(Trypanosoma
brucei) 		no annotation 4 VAL A 142
LEU A 119
PRO A 118
ASP A 143
 None
 1.06A 2ddwA-6f5dA:
undetectable		 2ddwA-6f5dA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9n CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
SUBUNIT 1
PRE-MRNA 3' END
PROCESSING PROTEIN
WDR33

(Homo sapiens) 		no annotation 4 VAL B  63
VAL A1227
PRO B  95
ASP A1226
 None
 1.07A 2ddwA-6f9nB:
undetectable		 2ddwA-6f9nB:
16.26