SIMILAR PATTERNS OF AMINO ACIDS FOR 2D55_C_DVAC8_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ajz DIHYDROPTEROATE
SYNTHASE

(Escherichia
coli) 		PF00809
(Pterin_bind) 		3 PRO A  64
THR A 147
PRO A 145
 None
 0.80A 2d55C-1ajzA:
undetectable		 2d55C-1ajzA:
5.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bvu PROTEIN (GLUTAMATE
DEHYDROGENASE)

(Thermococcus
litoralis) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		3 PRO A 143
THR A 174
PRO A 141
 None
 0.80A 2d55C-1bvuA:
undetectable		 2d55C-1bvuA:
3.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e19 CARBAMATE KINASE

(Pyrococcus
furiosus) 		PF00696
(AA_kinase) 		3 PRO A 132
THR A 130
PRO A 166
 None
 0.86A 2d55C-1e19A:
undetectable		 2d55C-1e19A:
5.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1evl THREONYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		3 PRO A 464
THR A 422
PRO A 424
 None
 0.58A 2d55C-1evlA:
undetectable		 2d55C-1evlA:
2.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g7c ELONGATION FACTOR
1-ALPHA

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		3 PRO A 187
THR A 185
PRO A 183
 None
 0.84A 2d55C-1g7cA:
undetectable		 2d55C-1g7cA:
6.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gju MALTODEXTRIN
GLYCOSYLTRANSFERASE

(Thermotoga
maritima) 		PF00128
(Alpha-amylase)
PF09083
(DUF1923) 		3 PRO A 340
THR A 267
PRO A 269
 None
 0.83A 2d55C-1gjuA:
undetectable		 2d55C-1gjuA:
2.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyo CYTOCHROME C3, A
DIMERIC CLASS III
C-TYPE CYTOCHROME

(Desulfovibrio
gigas) 		PF02085
(Cytochrom_CIII) 		3 PRO A  17
THR A  10
PRO A  12
 None
 0.81A 2d55C-1gyoA:
undetectable		 2d55C-1gyoA:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h74 HOMOSERINE KINASE

(Methanocaldococcus
jannaschii) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		3 PRO A  59
THR A  57
PRO A  56
 None
None
ADP  A 400 (-4.8A)
 0.79A 2d55C-1h74A:
undetectable		 2d55C-1h74A:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jkm BREFELDIN A ESTERASE

(Bacillus
subtilis) 		PF07859
(Abhydrolase_3) 		3 PRO A  27
THR A  25
PRO A  23
 None
 0.78A 2d55C-1jkmA:
undetectable		 2d55C-1jkmA:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k18 DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT

(Homo sapiens) 		no annotation 3 PRO A  26
THR A  21
PRO A  23
 None
 0.80A 2d55C-1k18A:
undetectable		 2d55C-1k18A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1no7 MAJOR CAPSID PROTEIN

(Human
alphaherpesvirus
1) 		PF03122
(Herpes_MCP) 		3 PRO A 861
THR A 859
PRO A 857
 None
 0.62A 2d55C-1no7A:
undetectable		 2d55C-1no7A:
2.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qf6 THREONYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF00587
(tRNA-synt_2b)
PF02824
(TGS)
PF03129
(HGTP_anticodon)
PF07973
(tRNA_SAD) 		3 PRO A 464
THR A 422
PRO A 424
 None
 0.71A 2d55C-1qf6A:
undetectable		 2d55C-1qf6A:
1.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qpp PAPD CHAPERONE

(Escherichia
coli) 		PF00345
(PapD_N)
PF02753
(PapD_C) 		3 PRO A  49
THR A  71
PRO A  73
 None
 0.84A 2d55C-1qppA:
undetectable		 2d55C-1qppA:
4.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wkr POLYPOROPEPSIN

(Irpex lacteus) 		PF00026
(Asp) 		3 PRO A 275
THR A 150
PRO A 149
 None
 0.84A 2d55C-1wkrA:
undetectable		 2d55C-1wkrA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x5k NEOGENIN

(Homo sapiens) 		PF00041
(fn3) 		3 PRO A  21
THR A  19
PRO A  18
 None
 0.82A 2d55C-1x5kA:
undetectable		 2d55C-1x5kA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xpg 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Thermotoga
maritima) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		3 PRO A 579
THR A 531
PRO A 533
 None
 0.79A 2d55C-1xpgA:
undetectable		 2d55C-1xpgA:
1.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zzm PUTATIVE
DEOXYRIBONUCLEASE
YJJV

(Escherichia
coli) 		PF01026
(TatD_DNase) 		3 PRO A 129
THR A 153
PRO A 151
 None
 0.68A 2d55C-1zzmA:
undetectable		 2d55C-1zzmA:
4.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2coa PROTEIN KINASE C, D2
TYPE

(Homo sapiens) 		PF00169
(PH) 		3 PRO A  92
THR A  72
PRO A  74
 None
 0.79A 2d55C-2coaA:
undetectable		 2d55C-2coaA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ece 462AA LONG
HYPOTHETICAL
SELENIUM-BINDING
PROTEIN

(Sulfurisphaera
tokodaii) 		PF05694
(SBP56) 		3 PRO A 120
THR A 113
PRO A 115
 None
 0.81A 2d55C-2eceA:
undetectable		 2d55C-2eceA:
5.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwc GLUTAMATE CYSTEINE
LIGASE

(Brassica juncea) 		PF04107
(GCS2) 		3 PRO A 160
THR A 215
PRO A 217
 BSC  A   2 (-4.4A)
None
None
 0.76A 2d55C-2gwcA:
undetectable		 2d55C-2gwcA:
4.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2imr HYPOTHETICAL PROTEIN
DR_0824

(Deinococcus
radiodurans) 		PF01979
(Amidohydro_1) 		3 PRO A 277
THR A 251
PRO A 279
 None
 0.82A 2d55C-2imrA:
undetectable		 2d55C-2imrA:
3.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kk2 EN-A1

(Euplotes
nobilii) 		no annotation 3 PRO A  13
THR A  11
PRO A   9
 None
 0.69A 2d55C-2kk2A:
undetectable		 2d55C-2kk2A:
7.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ldk UNCHARACTERIZED
PROTEIN

(Paenarthrobacter
aurescens) 		PF08327
(AHSA1) 		3 PRO A  68
THR A  45
PRO A  47
 None
 0.81A 2d55C-2ldkA:
undetectable		 2d55C-2ldkA:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n9p LARGE PROLINE-RICH
PROTEIN BAG6

(Homo sapiens) 		PF00240
(ubiquitin) 		3 PRO C  95
THR C  92
PRO C  90
 None
 0.78A 2d55C-2n9pC:
undetectable		 2d55C-2n9pC:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8r POLYPHOSPHATE KINASE

(Porphyromonas
gingivalis) 		PF02503
(PP_kinase)
PF13089
(PP_kinase_N)
PF13090
(PP_kinase_C) 		3 PRO A 123
THR A 121
PRO A 120
 None
SO4  A 709 (-3.9A)
SO4  A 709 (-4.7A)
 0.85A 2d55C-2o8rA:
undetectable		 2d55C-2o8rA:
1.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ov9 HYPOTHETICAL PROTEIN

(Rhodococcus
jostii) 		PF03061
(4HBT) 		3 PRO A 101
THR A  92
PRO A  90
 None
 0.78A 2d55C-2ov9A:
undetectable		 2d55C-2ov9A:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qv5 UNCHARACTERIZED
PROTEIN ATU2773

(Agrobacterium
fabrum) 		PF04748
(Polysacc_deac_2) 		3 PRO A 243
THR A 241
PRO A 239
 None
 0.72A 2d55C-2qv5A:
undetectable		 2d55C-2qv5A:
6.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6h NADH:UBIQUINONE
OXIDOREDUCTASE, NA
TRANSLOCATING, F
SUBUNIT

(Porphyromonas
gingivalis) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		3 PRO A 247
THR A 231
PRO A 233
 FAD  A   1 ( 4.7A)
None
FAD  A   1 ( 4.8A)
 0.58A 2d55C-2r6hA:
undetectable		 2d55C-2r6hA:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v2f PENICILLIN BINDING
PROTEIN 1A

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		3 PRO F 380
THR F 376
PRO F 374
 None
 0.85A 2d55C-2v2fF:
undetectable		 2d55C-2v2fF:
3.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4j SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA

(Desulfovibrio
vulgaris) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		3 PRO A 261
THR A 312
PRO A 314
 None
 0.79A 2d55C-2v4jA:
undetectable		 2d55C-2v4jA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2we5 CARBAMATE KINASE 1

(Enterococcus
faecalis) 		PF00696
(AA_kinase) 		3 PRO A 129
THR A 127
PRO A 162
 None
 0.77A 2d55C-2we5A:
undetectable		 2d55C-2we5A:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsx L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER

(Escherichia
coli) 		PF02028
(BCCT) 		3 PRO A 125
THR A 118
PRO A 120
 None
 0.67A 2d55C-2wsxA:
undetectable		 2d55C-2wsxA:
2.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yyl 4-HYDROXYPHENYLACETA
TE-3-HYDROXYLASE

(Thermus
thermophilus) 		PF03241
(HpaB)
PF11794
(HpaB_N) 		3 PRO A  33
THR A  31
PRO A  29
 None
 0.74A 2d55C-2yylA:
undetectable		 2d55C-2yylA:
3.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a68 FERRITIN-4,
CHLOROPLASTIC

(Glycine max) 		PF00210
(Ferritin) 		3 PRO A  32
THR A  30
PRO A  29
 None
 0.83A 2d55C-3a68A:
undetectable		 2d55C-3a68A:
5.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3drk OLIGOPEPTIDE-BINDING
PROTEIN OPPA

(Lactococcus
lactis) 		PF00496
(SBP_bac_5) 		3 PRO A 218
THR A 214
PRO A 212
 None
 0.72A 2d55C-3drkA:
undetectable		 2d55C-3drkA:
1.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7u CYTOSINE-SPECIFIC
METHYLTRANSFERASE

(Escherichia
coli) 		PF00145
(DNA_methylase) 		3 PRO A 188
THR A 190
PRO A 157
 None
 0.85A 2d55C-3g7uA:
undetectable		 2d55C-3g7uA:
3.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gaa UNCHARACTERIZED
PROTEIN TA1441

(Thermoplasma
acidophilum) 		PF09754
(PAC2) 		3 PRO A 129
THR A 189
PRO A 188
 None
 0.85A 2d55C-3gaaA:
undetectable		 2d55C-3gaaA:
4.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7y ML50

(Homo sapiens) 		PF01281
(Ribosomal_L9_N) 		3 PRO h 133
THR h  61
PRO h  63
 None
 0.82A 2d55C-3j7yh:
undetectable		 2d55C-3j7yh:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l5h INTERLEUKIN-6
RECEPTOR SUBUNIT
BETA

(Homo sapiens) 		PF00041
(fn3)
PF06328
(Lep_receptor_Ig)
PF09240
(IL6Ra-bind) 		3 PRO A 308
THR A 331
PRO A 333
 None
 0.80A 2d55C-3l5hA:
undetectable		 2d55C-3l5hA:
2.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3loy COPPER AMINE OXIDASE

(Ogataea angusta) 		PF01179
(Cu_amine_oxid) 		3 PRO A 486
THR A 549
PRO A 587
 None
 0.82A 2d55C-3loyA:
undetectable		 2d55C-3loyA:
3.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3luu UNCHARACTERIZED
PROTEIN

(Acidithiobacillus
ferrooxidans) 		PF06155
(DUF971) 		3 PRO A   8
THR A   6
PRO A   4
 None
 0.73A 2d55C-3luuA:
undetectable		 2d55C-3luuA:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nad FERULATE
DECARBOXYLASE

(Bacillus
pumilus) 		PF05870
(PA_decarbox) 		3 PRO A  88
THR A 118
PRO A 120
 None
 0.82A 2d55C-3nadA:
undetectable		 2d55C-3nadA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3noq THIJ/PFPI FAMILY
PROTEIN

(Pseudomonas
fluorescens) 		PF01965
(DJ-1_PfpI) 		3 PRO A 196
THR A 194
PRO A 192
 None
 0.85A 2d55C-3noqA:
undetectable		 2d55C-3noqA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L

(Homo sapiens) 		PF00856
(SET) 		3 PRO A2123
THR A2121
PRO A2119
 None
 0.75A 2d55C-3opeA:
undetectable		 2d55C-3opeA:
6.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r6k VP1 PROTEIN

(Norwalk virus) 		PF08435
(Calici_coat_C) 		3 PRO A 422
THR A 420
PRO A 419
 None
 0.80A 2d55C-3r6kA:
undetectable		 2d55C-3r6kA:
4.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqi KLLA0E03807P

(Kluyveromyces
lactis) 		PF16787
(NDC10_II) 		3 PRO A 198
THR A 196
PRO A 194
 None
 0.85A 2d55C-3sqiA:
undetectable		 2d55C-3sqiA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t79 KLLA0E03807P

(Kluyveromyces
lactis) 		PF16787
(NDC10_II) 		3 PRO A 198
THR A 196
PRO A 194
 None
 0.85A 2d55C-3t79A:
undetectable		 2d55C-3t79A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vmn DEXTRANASE

(Streptococcus
mutans) 		PF13199
(Glyco_hydro_66) 		3 PRO A 671
THR A 673
PRO A 715
 None
 0.81A 2d55C-3vmnA:
undetectable		 2d55C-3vmnA:
1.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfa ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		3 PRO A 548
THR A 545
PRO A 634
 None
 0.75A 2d55C-3wfaA:
undetectable		 2d55C-3wfaA:
2.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3whp PROBABLE
TRANSCRIPTIONAL
REGULATOR

(Thermus
thermophilus) 		PF02310
(B12-binding)
PF02607
(B12-binding_2) 		3 PRO A 173
THR A 202
PRO A 200
 None
 0.72A 2d55C-3whpA:
undetectable		 2d55C-3whpA:
4.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wjs NADH OXIDASE

(Gluconobacter
oxydans) 		PF00724
(Oxidored_FMN) 		3 PRO A 245
THR A 241
PRO A 239
 None
 0.83A 2d55C-3wjsA:
undetectable		 2d55C-3wjsA:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx9 CAPSID PROTEIN

(Turnip crinkle
virus) 		PF00729
(Viral_coat) 		3 PRO A 140
THR A 182
PRO A 180
 None
 0.68A 2d55C-3zx9A:
undetectable		 2d55C-3zx9A:
4.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		3 PRO A 283
THR A 281
PRO A 279
 None
 0.82A 2d55C-4bc6A:
undetectable		 2d55C-4bc6A:
7.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4efh ACTIN-1

(Acanthamoeba
castellanii) 		PF00022
(Actin) 		3 PRO A  98
THR A 129
PRO A 102
 None
 0.86A 2d55C-4efhA:
undetectable		 2d55C-4efhA:
5.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eo4 THREONINE--TRNA
LIGASE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		3 PRO A 272
THR A 230
PRO A 232
 None
 0.65A 2d55C-4eo4A:
undetectable		 2d55C-4eo4A:
6.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f1n KPAGO

(Vanderwaltozyma
polyspora) 		PF02171
(Piwi) 		3 PRO A 834
THR A 869
PRO A 871
 None
 0.80A 2d55C-4f1nA:
undetectable		 2d55C-4f1nA:
1.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9z ENDOPLASMIC
RETICULUM RESIDENT
PROTEIN 27

(Homo sapiens) 		no annotation 3 PRO D 236
THR D 237
PRO D 220
 None
 0.84A 2d55C-4f9zD:
undetectable		 2d55C-4f9zD:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fi9 SUN
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		PF07738
(Sad1_UNC) 		3 PRO A 607
THR A 696
PRO A 643
 None
 0.79A 2d55C-4fi9A:
undetectable		 2d55C-4fi9A:
7.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1p CYS-GLY
METALLODIPEPTIDASE
DUG1

(Saccharomyces
cerevisiae) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		3 PRO A 317
THR A 349
PRO A 351
 None
 0.83A 2d55C-4g1pA:
undetectable		 2d55C-4g1pA:
3.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwt THREONINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon) 		3 PRO A 575
THR A 533
PRO A 535
 None
 0.62A 2d55C-4hwtA:
undetectable		 2d55C-4hwtA:
3.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ixw HALOHYDRIN
DEHALOGENASE

(Agrobacterium
tumefaciens) 		PF13561
(adh_short_C2) 		3 PRO A 196
THR A 194
PRO A 191
 None
 0.83A 2d55C-4ixwA:
undetectable		 2d55C-4ixwA:
2.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4knh NUP192P

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		3 PRO A 701
THR A 676
PRO A 678
 None
 0.65A 2d55C-4knhA:
undetectable		 2d55C-4knhA:
1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgl GLYCINE
DEHYDROGENASE
[DECARBOXYLATING]

(Synechocystis
sp. PCC 6803) 		PF02347
(GDC-P) 		3 PRO A 777
THR A 755
PRO A 753
 None
 0.80A 2d55C-4lglA:
undetectable		 2d55C-4lglA:
1.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n1a CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata) 		PF01580
(FtsK_SpoIIIE) 		3 PRO A 854
THR A1064
PRO A1066
 None
 0.65A 2d55C-4n1aA:
undetectable		 2d55C-4n1aA:
2.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n2z GH62
ARABINOFURANOSIDASE

(Podospora
anserina) 		PF03664
(Glyco_hydro_62) 		3 PRO A  96
THR A 140
PRO A 142
 None
 0.58A 2d55C-4n2zA:
undetectable		 2d55C-4n2zA:
5.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n7t PHOSPHOPENTOMUTASE

(Streptococcus
mutans) 		PF01676
(Metalloenzyme) 		3 PRO A  62
THR A  81
PRO A 357
 GOL  A 505 (-4.8A)
None
None
 0.83A 2d55C-4n7tA:
undetectable		 2d55C-4n7tA:
3.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata) 		PF01580
(FtsK_SpoIIIE) 		3 PRO A 854
THR A1064
PRO A1066
 None
 0.62A 2d55C-4nh0A:
undetectable		 2d55C-4nh0A:
2.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F

(Vibrio cholerae) 		PF00111
(Fer2)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		3 PRO F 242
THR F 232
PRO F 234
 None
None
FAD  F 502 (-4.7A)
 0.46A 2d55C-4p6vF:
undetectable		 2d55C-4p6vF:
3.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pka PATATIN-17

(Solanum
cardiophyllum) 		PF01734
(Patatin) 		3 PRO X 191
THR X 192
PRO X 123
 None
 0.84A 2d55C-4pkaX:
undetectable		 2d55C-4pkaX:
3.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pvi GH62 HYDROLASE

(Mycothermus
thermophilus) 		PF03664
(Glyco_hydro_62) 		3 PRO A 102
THR A 146
PRO A 148
 None
None
PO4  A 602 ( 4.5A)
 0.52A 2d55C-4pviA:
undetectable		 2d55C-4pviA:
2.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rns PCP DEGRADATION
TRANSCRIPTIONAL
ACTIVATION PROTEIN

(Sphingobium
chlorophenolicum) 		PF03466
(LysR_substrate) 		3 PRO A  92
THR A 122
PRO A 124
 None
 0.70A 2d55C-4rnsA:
undetectable		 2d55C-4rnsA:
54.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ru0 PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC
BRANCHED-CHAIN AMINO
ACID-BINDING PROTEIN

(Pseudomonas
protegens) 		PF13458
(Peripla_BP_6) 		3 PRO A 437
THR A 142
PRO A 145
 None
 0.81A 2d55C-4ru0A:
undetectable		 2d55C-4ru0A:
2.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9u NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F

(Vibrio cholerae) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		3 PRO A 242
THR A 232
PRO A 234
 FAD  A1501 (-4.8A)
None
None
 0.44A 2d55C-4u9uA:
undetectable		 2d55C-4u9uA:
2.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztu DNA POLYMERASE
SUBUNIT GAMMA-2,
MITOCHONDRIAL

(Homo sapiens) 		PF03129
(HGTP_anticodon) 		3 PRO B 205
THR B 243
PRO B 333
 None
 0.79A 2d55C-4ztuB:
undetectable		 2d55C-4ztuB:
1.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b6t GLYCOSYL HYDROLASE
FAMILY 62 PROTEIN

(Coprinopsis
cinerea) 		PF03664
(Glyco_hydro_62) 		3 PRO A 156
THR A 200
PRO A 202
 None
 0.50A 2d55C-5b6tA:
undetectable		 2d55C-5b6tA:
3.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c53 POL GAMMA B

(Homo sapiens) 		PF03129
(HGTP_anticodon) 		3 PRO B 205
THR B 243
PRO B 333
 None
 0.77A 2d55C-5c53B:
undetectable		 2d55C-5c53B:
1.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c8a LIGHT-DEPENDENT
TRANSCRIPTIONAL
REGULATOR CARH

(Thermus
thermophilus) 		PF02310
(B12-binding)
PF02607
(B12-binding_2) 		3 PRO A 173
THR A 202
PRO A 200
 None
 0.76A 2d55C-5c8aA:
undetectable		 2d55C-5c8aA:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmq REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H P80

(Murine leukemia
virus) 		PF00075
(RNase_H)
PF00078
(RVT_1) 		3 PRO A 130
THR A 128
PRO A 127
 None
 0.81A 2d55C-5dmqA:
undetectable		 2d55C-5dmqA:
2.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4s CONTACTIN-4

(Mus musculus) 		PF00041
(fn3) 		3 PRO A 703
THR A 722
PRO A 724
 None
 0.74A 2d55C-5e4sA:
undetectable		 2d55C-5e4sA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e52 CONTACTIN-5

(Homo sapiens) 		PF00041
(fn3) 		3 PRO A 861
THR A 775
PRO A 777
 None
 0.85A 2d55C-5e52A:
undetectable		 2d55C-5e52A:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ecu CELLULASE

(Caldicellulosiruptor
saccharolyticus) 		PF00150
(Cellulase)
PF03424
(CBM_17_28) 		3 PRO A 231
THR A 197
PRO A 191
 None
 0.86A 2d55C-5ecuA:
undetectable		 2d55C-5ecuA:
6.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ed8 MKIAA0668 PROTEIN

(Mus musculus) 		PF07738
(Sad1_UNC) 		3 PRO A 589
THR A 678
PRO A 625
 None
 0.76A 2d55C-5ed8A:
undetectable		 2d55C-5ed8A:
5.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fhy B-TYPE FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 2

(Pseudomonas
aeruginosa) 		PF07195
(FliD_C)
PF07196
(Flagellin_IN) 		3 PRO A 215
THR A 213
PRO A 211
 None
 0.82A 2d55C-5fhyA:
undetectable		 2d55C-5fhyA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fp2 FERRIC ENTEROBACTIN
RECEPTOR PIRA

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 PRO A 191
THR A 159
PRO A 158
 None
 0.78A 2d55C-5fp2A:
undetectable		 2d55C-5fp2A:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASA

(Escherichia
coli) 		PF09481
(CRISPR_Cse1) 		3 PRO A 171
THR A 173
PRO A 283
 None
 0.85A 2d55C-5h9fA:
undetectable		 2d55C-5h9fA:
2.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iu9 PROTOCADHERIN-19
ISOFORM 1

(Danio rerio) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		3 PRO A 242
THR A 240
PRO A 213
 None
 0.64A 2d55C-5iu9A:
undetectable		 2d55C-5iu9A:
3.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j4r WELO5

(Hapalosiphon
welwitschii) 		no annotation 3 PRO A 246
THR A 195
PRO A 197
 None
 0.87A 2d55C-5j4rA:
undetectable		 2d55C-5j4rA:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq3 CMEB

(Campylobacter
jejuni) 		PF00873
(ACR_tran) 		3 PRO A 719
THR A 717
PRO A 807
 None
 0.76A 2d55C-5lq3A:
undetectable		 2d55C-5lq3A:
2.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nyy NON-SPECIFIC
SERINE/THREONINE
PROTEIN KINASE

(Thermomonospora
curvata) 		PF03781
(FGE-sulfatase) 		3 PRO A 251
THR A 247
PRO A 245
 None
 0.80A 2d55C-5nyyA:
undetectable		 2d55C-5nyyA:
4.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5the UNCHARACTERIZED
PROTEIN

(Vanderwaltozyma
polyspora) 		no annotation 3 PRO A 834
THR A 869
PRO A 871
 None
 0.78A 2d55C-5theA:
undetectable		 2d55C-5theA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpk PROTOCADHERIN-15

(Mus musculus) 		no annotation 3 PRO A 723
THR A 721
PRO A 694
 None
 0.81A 2d55C-5tpkA:
undetectable		 2d55C-5tpkA:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uhe DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA'

(Mycobacterium
tuberculosis) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		3 PRO D 398
THR D 392
PRO D 394
 None
 0.81A 2d55C-5uheD:
undetectable		 2d55C-5uheD:
0.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfa NAD-REDUCING
HYDROGENASE

(Hydrogenophilus
thermoluteolus) 		PF01257
(2Fe-2S_thioredx)
PF01512
(Complex1_51K)
PF10589
(NADH_4Fe-4S) 		3 PRO A 340
THR A 350
PRO A 349
 None
 0.75A 2d55C-5xfaA:
undetectable		 2d55C-5xfaA:
2.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfa NAD-REDUCING
HYDROGENASE

(Hydrogenophilus
thermoluteolus) 		PF01257
(2Fe-2S_thioredx)
PF01512
(Complex1_51K)
PF10589
(NADH_4Fe-4S) 		3 PRO A 349
THR A 342
PRO A 340
 None
 0.76A 2d55C-5xfaA:
undetectable		 2d55C-5xfaA:
2.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjy ATP-BINDING CASSETTE
SUB-FAMILY A MEMBER
1

(Homo sapiens) 		PF00005
(ABC_tran)
PF12698
(ABC2_membrane_3) 		3 PRO A  62
THR A  66
PRO A  68
 None
 0.81A 2d55C-5xjyA:
undetectable		 2d55C-5xjyA:
0.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ybb RESTRICTION
ENDONUCLEASE S
SUBUNITS

(Caldanaerobacter
subterraneus) 		no annotation 3 PRO D 143
THR D  81
PRO D  83
 None
 0.48A 2d55C-5ybbD:
undetectable		 2d55C-5ybbD:
3.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE

(Methanosarcinales) 		no annotation 3 PRO A 213
THR A  93
PRO A  92
 None
 0.83A 2d55C-6c8zA:
undetectable		 2d55C-6c8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cza -

(-) 		no annotation 3 PRO A 121
THR A 119
PRO A 129
 None
 0.83A 2d55C-6czaA:
undetectable		 2d55C-6czaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6elc VARIANT SURFACE
GLYCOPROTEIN

(Trypanosoma
brucei) 		no annotation 3 PRO A 172
THR A  48
PRO A  50
 None
 0.75A 2d55C-6elcA:
undetectable		 2d55C-6elcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eom MUTT/NUDIX FAMILY
PROTEIN

(Caldithrix
abyssi) 		no annotation 3 PRO A 546
THR A  42
PRO A  41
 None
 0.83A 2d55C-6eomA:
undetectable		 2d55C-6eomA:
undetectable