SIMILAR PATTERNS OF AMINO ACIDS FOR 2D55_C_DVAC2_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5l UREASE (ALPHA
SUBUNIT)


(Klebsiella
aerogenes)
PF00449
(Urease_alpha)
PF01979
(Amidohydro_1)
3 THR C 301
PRO C 303
PRO C 300
None
0.86A 2d55C-1a5lC:
undetectable
2d55C-1a5lC:
5.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ai1 IGG1-KAPPA 59.1 FAB
(HEAVY CHAIN)


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
3 THR H 117
PRO H 149
PRO H 118
None
0.90A 2d55C-1ai1H:
undetectable
2d55C-1ai1H:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1as4 ANTICHYMOTRYPSIN

(Homo sapiens)
PF00079
(Serpin)
3 THR B 389
PRO B 391
PRO B 369
None
0.77A 2d55C-1as4B:
undetectable
2d55C-1as4B:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bjw ASPARTATE
AMINOTRANSFERASE


(Thermus
thermophilus)
PF00155
(Aminotran_1_2)
3 THR A 265
PRO A 267
PRO A  67
None
0.84A 2d55C-1bjwA:
undetectable
2d55C-1bjwA:
2.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgm ADENOSINE KINASE

(Toxoplasma
gondii)
PF00294
(PfkB)
3 THR A  10
PRO A  12
PRO A  85
None
0.83A 2d55C-1dgmA:
undetectable
2d55C-1dgmA:
3.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e9y UREASE SUBUNIT BETA

(Helicobacter
pylori)
PF00449
(Urease_alpha)
PF01979
(Amidohydro_1)
3 THR B 303
PRO B 305
PRO B 302
None
0.85A 2d55C-1e9yB:
undetectable
2d55C-1e9yB:
2.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fnf FIBRONECTIN

(Homo sapiens)
PF00041
(fn3)
3 THR A1157
PRO A1155
PRO A1237
None
0.78A 2d55C-1fnfA:
undetectable
2d55C-1fnfA:
3.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1icp 12-OXOPHYTODIENOATE
REDUCTASE 1


(Solanum
lycopersicum)
PF00724
(Oxidored_FMN)
3 THR A  74
PRO A 129
PRO A 124
None
0.74A 2d55C-1icpA:
undetectable
2d55C-1icpA:
6.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ikf IGG1-KAPPA R45-45-11
FAB (HEAVY CHAIN)


(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
3 THR H 130
PRO H 160
PRO H 131
None
0.89A 2d55C-1ikfH:
undetectable
2d55C-1ikfH:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0h NEOPULLULANASE

(Geobacillus
stearothermophilus)
PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C)
3 THR A 280
PRO A 282
PRO A 284
None
0.85A 2d55C-1j0hA:
undetectable
2d55C-1j0hA:
1.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l3w EP-CADHERIN

(Xenopus laevis)
PF00028
(Cadherin)
3 THR A  63
PRO A  65
PRO A  18
None
0.90A 2d55C-1l3wA:
undetectable
2d55C-1l3wA:
4.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfd N15 ALPHA-BETA
T-CELL RECEPTOR


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
3 THR B 123
PRO B 125
PRO B 232
None
0.85A 2d55C-1nfdB:
undetectable
2d55C-1nfdB:
7.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1op2 VENOM SERINE
PROTEINASE


(Deinagkistrodon
acutus)
PF00089
(Trypsin)
3 THR A 245
PRO A 245
PRO A  92
None
0.78A 2d55C-1op2A:
undetectable
2d55C-1op2A:
4.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qmn ALPHA-1-ANTICHYMOTRY
PSIN


(Homo sapiens)
PF00079
(Serpin)
3 THR A 393
PRO A 395
PRO A 373
None
0.79A 2d55C-1qmnA:
undetectable
2d55C-1qmnA:
2.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qoi SNUCYP-20

(Homo sapiens)
PF00160
(Pro_isomerase)
3 THR A 159
PRO A 161
PRO A 165
None
0.84A 2d55C-1qoiA:
undetectable
2d55C-1qoiA:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1smr RENIN

(Mus musculus)
PF00026
(Asp)
3 THR A 295
PRO A 297
PRO A 294
None
0.81A 2d55C-1smrA:
undetectable
2d55C-1smrA:
7.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ujx POLYNUCLEOTIDE
KINASE
3'-PHOSPHATASE


(Mus musculus)
no annotation 3 THR A  46
PRO A  44
PRO A  26
None
0.90A 2d55C-1ujxA:
undetectable
2d55C-1ujxA:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1waq GROWTH/DIFFERENTIATI
ON FACTOR 5


(Homo sapiens)
PF00019
(TGF_beta)
3 THR A  80
PRO A  77
PRO A  81
None
0.85A 2d55C-1waqA:
undetectable
2d55C-1waqA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2coa PROTEIN KINASE C, D2
TYPE


(Homo sapiens)
PF00169
(PH)
3 THR A  72
PRO A  74
PRO A  92
None
0.89A 2d55C-2coaA:
undetectable
2d55C-2coaA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw7 ENDONUCLEASE
PI-PKOII


(Thermococcus
kodakarensis)
PF14528
(LAGLIDADG_3)
PF14890
(Intein_splicing)
3 THR A 366
PRO A 368
PRO A 129
None
0.84A 2d55C-2cw7A:
undetectable
2d55C-2cw7A:
2.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfv PROBABLE L-THREONINE
3-DEHYDROGENASE


(Pyrococcus
horikoshii)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
3 THR A  11
PRO A  13
PRO A  62
None
0.84A 2d55C-2dfvA:
undetectable
2d55C-2dfvA:
4.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ece 462AA LONG
HYPOTHETICAL
SELENIUM-BINDING
PROTEIN


(Sulfurisphaera
tokodaii)
PF05694
(SBP56)
3 THR A 113
PRO A 115
PRO A 120
None
0.27A 2d55C-2eceA:
undetectable
2d55C-2eceA:
5.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g1s RENIN

(Homo sapiens)
PF00026
(Asp)
3 THR A 304
PRO A 306
PRO A 303
None
0.70A 2d55C-2g1sA:
undetectable
2d55C-2g1sA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2it4 CARBONIC ANHYDRASE 1

(Homo sapiens)
PF00194
(Carb_anhydrase)
3 THR A 248
PRO A 250
PRO A  30
None
0.71A 2d55C-2it4A:
undetectable
2d55C-2it4A:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jg2 SERINE
PALMITOYLTRANSFERASE


(Sphingomonas
paucimobilis)
PF00155
(Aminotran_1_2)
3 THR A 382
PRO A 380
PRO A 383
None
0.87A 2d55C-2jg2A:
undetectable
2d55C-2jg2A:
2.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nwh CARBOHYDRATE KINASE

(Agrobacterium
fabrum)
PF00294
(PfkB)
3 THR A  84
PRO A  59
PRO A  82
None
0.89A 2d55C-2nwhA:
undetectable
2d55C-2nwhA:
2.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2omz EPITHELIAL-CADHERIN

(Homo sapiens)
PF00028
(Cadherin)
3 THR B  63
PRO B  65
PRO B  18
None
0.79A 2d55C-2omzB:
undetectable
2d55C-2omzB:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2otn DIAMINOPIMELATE
EPIMERASE


(Bacillus
anthracis)
PF01678
(DAP_epimerase)
3 THR A 182
PRO A 180
PRO A 186
None
0.75A 2d55C-2otnA:
undetectable
2d55C-2otnA:
5.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q01 URONATE ISOMERASE

(Caulobacter
vibrioides)
PF02614
(UxaC)
3 THR A  19
PRO A  17
PRO A  14
None
0.82A 2d55C-2q01A:
undetectable
2d55C-2q01A:
2.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3r 12-OXOPHYTODIENOATE
REDUCTASE 1


(Arabidopsis
thaliana)
PF00724
(Oxidored_FMN)
3 THR A  70
PRO A 125
PRO A 120
None
0.88A 2d55C-2q3rA:
undetectable
2d55C-2q3rA:
3.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r14 MORPHINONE REDUCTASE

(Pseudomonas
putida)
PF00724
(Oxidored_FMN)
3 THR A  68
PRO A 123
PRO A 118
None
0.72A 2d55C-2r14A:
undetectable
2d55C-2r14A:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3s UNCHARACTERIZED
PROTEIN


(Nostoc
punctiforme)
PF00891
(Methyltransf_2)
PF16864
(Dimerisation2)
3 THR A 279
PRO A 273
PRO A 281
None
0.84A 2d55C-2r3sA:
undetectable
2d55C-2r3sA:
3.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2j CARBONIC
ANHYDRASE-RELATED
PROTEIN


(Homo sapiens)
PF00194
(Carb_anhydrase)
3 THR A 277
PRO A 279
PRO A  51
GOL  A 502 ( 4.4A)
None
None
0.76A 2d55C-2w2jA:
undetectable
2d55C-2w2jA:
4.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsj P-COUMARIC ACID
DECARBOXYLASE


(Lactobacillus
plantarum)
PF05870
(PA_decarbox)
3 THR A 125
PRO A 127
PRO A  95
None
0.52A 2d55C-2wsjA:
undetectable
2d55C-2wsjA:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsx L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER


(Escherichia
coli)
PF02028
(BCCT)
3 THR A 118
PRO A 120
PRO A 125
None
0.89A 2d55C-2wsxA:
undetectable
2d55C-2wsxA:
2.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzf GLUCOSYLTRANSFERASE

(Legionella
pneumophila)
PF16849
(Glyco_transf_88)
3 THR A 478
PRO A 476
PRO A 480
None
0.71A 2d55C-2wzfA:
undetectable
2d55C-2wzfA:
2.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzg GLUCOSYLTRANSFERASE

(Legionella
pneumophila)
PF16849
(Glyco_transf_88)
3 THR A 478
PRO A 476
PRO A 480
None
0.70A 2d55C-2wzgA:
undetectable
2d55C-2wzgA:
2.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ycj 5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE


(Carboxydothermus
hydrogenoformans)
PF00809
(Pterin_bind)
3 THR A 156
PRO A 192
PRO A 154
None
0.75A 2d55C-2ycjA:
undetectable
2d55C-2ycjA:
5.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1n NDP-SUGAR EPIMERASE

(Thermoplasma
volcanium)
PF01370
(Epimerase)
3 THR A 272
PRO A 274
PRO A 118
None
0.83A 2d55C-3a1nA:
undetectable
2d55C-3a1nA:
7.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3b CASEIN KINASE II
SUBUNIT ALPHA'


(Homo sapiens)
PF00069
(Pkinase)
3 THR X 109
PRO X 105
PRO X 110
None
0.79A 2d55C-3e3bX:
undetectable
2d55C-3e3bX:
2.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqx FIC DOMAIN
CONTAINING
TRANSCRIPTIONAL
REGULATOR


(Shewanella
oneidensis)
PF02661
(Fic)
PF13784
(Fic_N)
3 THR A 143
PRO A 141
PRO A 157
None
0.88A 2d55C-3eqxA:
undetectable
2d55C-3eqxA:
3.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ez1 AMINOTRANSFERASE
MOCR FAMILY


(Deinococcus
geothermalis)
PF12897
(Aminotran_MocR)
3 THR A 376
PRO A 378
PRO A 131
None
0.78A 2d55C-3ez1A:
undetectable
2d55C-3ez1A:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f1z PUTATIVE NUCLEIC
ACID-BINDING
LIPOPROTEIN


(Klebsiella
pneumoniae)
PF12869
(tRNA_anti-like)
3 THR A 143
PRO A 145
PRO A  61
None
0.75A 2d55C-3f1zA:
undetectable
2d55C-3f1zA:
7.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fe4 CARBONIC ANHYDRASE 6

(Homo sapiens)
PF00194
(Carb_anhydrase)
3 THR A 266
PRO A 268
PRO A  49
None
0.84A 2d55C-3fe4A:
undetectable
2d55C-3fe4A:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gfb L-THREONINE
3-DEHYDROGENASE


(Thermococcus
kodakarensis)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
3 THR A  11
PRO A  13
PRO A  62
None
0.84A 2d55C-3gfbA:
undetectable
2d55C-3gfbA:
4.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hgo 12-OXOPHYTODIENOATE
REDUCTASE 3


(Solanum
lycopersicum)
PF00724
(Oxidored_FMN)
3 THR A  70
PRO A 125
PRO A 120
None
0.81A 2d55C-3hgoA:
undetectable
2d55C-3hgoA:
4.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hz6 XYLULOKINASE

(Chromobacterium
violaceum)
PF00370
(FGGY_N)
PF02782
(FGGY_C)
3 THR A 283
PRO A 355
PRO A 300
None
None
XUL  A 515 (-4.2A)
0.82A 2d55C-3hz6A:
undetectable
2d55C-3hz6A:
2.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la4 UREASE

(Canavalia
ensiformis)
PF00449
(Urease_alpha)
PF00547
(Urease_gamma)
PF00699
(Urease_beta)
PF01979
(Amidohydro_1)
3 THR A 574
PRO A 576
PRO A 573
None
0.90A 2d55C-3la4A:
undetectable
2d55C-3la4A:
3.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3loy COPPER AMINE OXIDASE

(Ogataea angusta)
PF01179
(Cu_amine_oxid)
3 THR A 549
PRO A 587
PRO A 486
None
0.79A 2d55C-3loyA:
undetectable
2d55C-3loyA:
3.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lr2 MAJOR AMPULLATE
SPIDROIN 1


(Euprosthenops
australis)
PF16763
(Spidroin_N)
3 THR A  11
PRO A  13
PRO A  63
None
0.84A 2d55C-3lr2A:
undetectable
2d55C-3lr2A:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mtv PAPAIN-LIKE CYSTEINE
PROTEASE


(Porcine
reproductive
and respiratory
syndrome virus)
PF05411
(Peptidase_C32)
3 THR A  84
PRO A  86
PRO A 169
None
0.86A 2d55C-3mtvA:
undetectable
2d55C-3mtvA:
7.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nad FERULATE
DECARBOXYLASE


(Bacillus
pumilus)
PF05870
(PA_decarbox)
3 THR A 118
PRO A 120
PRO A  88
None
0.49A 2d55C-3nadA:
undetectable
2d55C-3nadA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oad RENIN

(Homo sapiens)
PF00026
(Asp)
3 THR B 309
PRO B 311
PRO B 308
None
0.82A 2d55C-3oadB:
undetectable
2d55C-3oadB:
6.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q2v CADHERIN-1

(Mus musculus)
PF00028
(Cadherin)
3 THR A  63
PRO A  65
PRO A  18
None
0.79A 2d55C-3q2vA:
undetectable
2d55C-3q2vA:
3.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5t TCR N30 BETA

(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
3 THR A 121
PRO A 123
PRO A 226
None
0.90A 2d55C-3q5tA:
undetectable
2d55C-3q5tA:
7.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qgk UREASE SUBUNIT BETA
2


(Helicobacter
mustelae)
PF00449
(Urease_alpha)
PF01979
(Amidohydro_1)
3 THR C 302
PRO C 304
PRO C 301
None
0.81A 2d55C-3qgkC:
undetectable
2d55C-3qgkC:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rcz SUMO-CONJUGATING
ENZYME UBC9


(Schizosaccharomyces
pombe)
PF00179
(UQ_con)
3 THR B  70
PRO B  72
PRO B 105
None
0.85A 2d55C-3rczB:
undetectable
2d55C-3rczB:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s69 THROMBIN-LIKE ENZYME
DEFIBRASE


(Gloydius
saxatilis)
PF00089
(Trypsin)
3 THR A 246
PRO A 248
PRO A  90
None
0.82A 2d55C-3s69A:
undetectable
2d55C-3s69A:
4.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsd INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE


(Bacillus
anthracis)
PF00478
(IMPDH)
PF00571
(CBS)
3 THR A 164
PRO A 166
PRO A 187
None
0.84A 2d55C-3tsdA:
undetectable
2d55C-3tsdA:
4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txa CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN


(Streptococcus
agalactiae)
PF00092
(VWA)
3 THR A 707
PRO A 705
PRO A 699
None
0.83A 2d55C-3txaA:
undetectable
2d55C-3txaA:
1.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4p INTEGRIN ALPHA-4

(Homo sapiens)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2)
3 THR A  40
PRO A  52
PRO A  39
15P  A 612 (-3.4A)
None
None
0.86A 2d55C-3v4pA:
undetectable
2d55C-3v4pA:
1.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3waj TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE


(Archaeoglobus
fulgidus)
PF02516
(STT3)
3 THR A  72
PRO A  75
PRO A 565
None
0.79A 2d55C-3wajA:
undetectable
2d55C-3wajA:
1.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3whp PROBABLE
TRANSCRIPTIONAL
REGULATOR


(Thermus
thermophilus)
PF02310
(B12-binding)
PF02607
(B12-binding_2)
3 THR A 202
PRO A 200
PRO A 173
None
0.90A 2d55C-3whpA:
undetectable
2d55C-3whpA:
4.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx9 CAPSID PROTEIN

(Turnip crinkle
virus)
PF00729
(Viral_coat)
3 THR A 182
PRO A 180
PRO A 140
None
0.82A 2d55C-3zx9A:
undetectable
2d55C-3zx9A:
4.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4alb PHENOLIC ACID
DECARBOXYLASE PADC


(Bacillus
subtilis)
PF05870
(PA_decarbox)
3 THR A 118
PRO A 120
PRO A  88
None
0.56A 2d55C-4albA:
undetectable
2d55C-4albA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b2n 70 KDA PROTEIN

(Xanthomonas sp.
35Y)
no annotation 3 THR A 512
PRO A 514
PRO A 212
None
0.90A 2d55C-4b2nA:
undetectable
2d55C-4b2nA:
1.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bb9 GLUCOKINASE
REGULATORY PROTEIN


(Homo sapiens)
no annotation 3 THR A  31
PRO A 251
PRO A  29
None
0.89A 2d55C-4bb9A:
undetectable
2d55C-4bb9A:
1.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f1n KPAGO

(Vanderwaltozyma
polyspora)
PF02171
(Piwi)
3 THR A 869
PRO A 871
PRO A 834
None
0.65A 2d55C-4f1nA:
undetectable
2d55C-4f1nA:
1.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fi9 SUN
DOMAIN-CONTAINING
PROTEIN 2


(Homo sapiens)
PF07738
(Sad1_UNC)
3 THR A 696
PRO A 643
PRO A 607
None
0.71A 2d55C-4fi9A:
undetectable
2d55C-4fi9A:
7.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7e UREASE

(Cajanus cajan)
PF00449
(Urease_alpha)
PF00547
(Urease_gamma)
PF00699
(Urease_beta)
PF01979
(Amidohydro_1)
3 THR B 574
PRO B 576
PRO B 573
None
0.89A 2d55C-4g7eB:
undetectable
2d55C-4g7eB:
3.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxy PLM1

(Streptomyces
sp. HK803)
PF08659
(KR)
3 THR A  79
PRO A  81
PRO A  54
None
0.81A 2d55C-4hxyA:
undetectable
2d55C-4hxyA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k2x POLYKETIDE
OXYGENASE/HYDROXYLAS
E


(Streptomyces
rimosus)
PF01494
(FAD_binding_3)
3 THR A 138
PRO A 140
PRO A 143
None
0.89A 2d55C-4k2xA:
undetectable
2d55C-4k2xA:
2.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n2z GH62
ARABINOFURANOSIDASE


(Podospora
anserina)
PF03664
(Glyco_hydro_62)
3 THR A 140
PRO A 142
PRO A  96
None
0.72A 2d55C-4n2zA:
undetectable
2d55C-4n2zA:
5.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n7t PHOSPHOPENTOMUTASE

(Streptococcus
mutans)
PF01676
(Metalloenzyme)
3 THR A  81
PRO A 357
PRO A  62
None
None
GOL  A 505 (-4.8A)
0.76A 2d55C-4n7tA:
undetectable
2d55C-4n7tA:
3.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pvi GH62 HYDROLASE

(Mycothermus
thermophilus)
PF03664
(Glyco_hydro_62)
3 THR A 146
PRO A 148
PRO A 102
None
PO4  A 602 ( 4.5A)
None
0.71A 2d55C-4pviA:
undetectable
2d55C-4pviA:
2.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q4y COXSACKIEVIRUS
CAPSID PROTEIN VP1
COXSACKIEVIRUS
CAPSID PROTEIN VP4


(Enterovirus C;
Enterovirus C)
PF00073
(Rhv)
PF02226
(Pico_P1A)
3 THR 4  64
PRO 4  66
PRO 1  42
None
0.89A 2d55C-4q4y4:
undetectable
2d55C-4q4y4:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ra7 PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE


(Atopobium
parvulum)
PF00905
(Transpeptidase)
3 THR A 640
PRO A 830
PRO A 849
None
0.90A 2d55C-4ra7A:
undetectable
2d55C-4ra7A:
3.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB


(Lactococcus
lactis)
PF04738
(Lant_dehydr_N)
PF14028
(Lant_dehydr_C)
3 THR A 777
PRO A 779
PRO A 781
None
0.86A 2d55C-4wd9A:
undetectable
2d55C-4wd9A:
3.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x5l DOWN SYNDROME CELL
ADHESION MOLECULE,
ISOFORM AM


(Drosophila
melanogaster)
PF13927
(Ig_3)
3 THR A  82
PRO A  84
PRO A   3
None
0.89A 2d55C-4x5lA:
undetectable
2d55C-4x5lA:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)


(Sulfurihydrogenibium
azorense)
PF00194
(Carb_anhydrase)
3 THR A 213
PRO A 215
PRO A  31
None
0.82A 2d55C-4x5sA:
undetectable
2d55C-4x5sA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yfg RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE DELTA


(Mus musculus)
no annotation 3 THR B  29
PRO B  58
PRO B  30
None
0.82A 2d55C-4yfgB:
undetectable
2d55C-4yfgB:
5.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yh7 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE DELTA


(Mus musculus)
PF00041
(fn3)
PF07679
(I-set)
PF13927
(Ig_3)
3 THR A  29
PRO A  58
PRO A  30
None
0.83A 2d55C-4yh7A:
undetectable
2d55C-4yh7A:
2.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z42 UREASE SUBUNIT ALPHA

(Yersinia
enterocolitica)
PF00449
(Urease_alpha)
PF01979
(Amidohydro_1)
3 THR C 306
PRO C 308
PRO C 305
None
0.89A 2d55C-4z42C:
undetectable
2d55C-4z42C:
3.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztu DNA POLYMERASE
SUBUNIT GAMMA-2,
MITOCHONDRIAL


(Homo sapiens)
PF03129
(HGTP_anticodon)
3 THR B 243
PRO B 333
PRO B 205
None
0.79A 2d55C-4ztuB:
undetectable
2d55C-4ztuB:
1.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a29 EXOPOLYGALACTURONATE
LYASE


(Vibrio
vulnificus)
PF06917
(Pectate_lyase_2)
3 THR A 282
PRO A 284
PRO A 222
None
0.89A 2d55C-5a29A:
undetectable
2d55C-5a29A:
1.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b6t GLYCOSYL HYDROLASE
FAMILY 62 PROTEIN


(Coprinopsis
cinerea)
PF03664
(Glyco_hydro_62)
3 THR A 200
PRO A 202
PRO A 156
None
0.74A 2d55C-5b6tA:
undetectable
2d55C-5b6tA:
3.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c53 POL GAMMA B

(Homo sapiens)
PF03129
(HGTP_anticodon)
3 THR B 243
PRO B 333
PRO B 205
None
0.76A 2d55C-5c53B:
undetectable
2d55C-5c53B:
1.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dv5 GNTR FAMILY
TRANSCRIPTIONAL
REGULATOR


(Vibrio
alginolyticus)
PF00392
(GntR)
PF07840
(FadR_C)
3 THR A 272
PRO A   8
PRO A 271
None
0.87A 2d55C-5dv5A:
undetectable
2d55C-5dv5A:
2.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ed8 MKIAA0668 PROTEIN

(Mus musculus)
PF07738
(Sad1_UNC)
3 THR A 678
PRO A 625
PRO A 589
None
0.80A 2d55C-5ed8A:
undetectable
2d55C-5ed8A:
5.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1i PLECTIN

(Homo sapiens)
no annotation 3 THR A1148
PRO A1146
PRO A1150
None
0.81A 2d55C-5j1iA:
undetectable
2d55C-5j1iA:
4.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jow NON-REDUCING END
ALPHA-L-ARABINOFURAN
OSIDASE BOGH43A


(Bacteroides
ovatus)
PF04616
(Glyco_hydro_43)
3 THR A  76
PRO A  78
PRO A  55
None
0.90A 2d55C-5jowA:
undetectable
2d55C-5jowA:
2.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k21 PYOCYANIN
DEMETHYLASE


(Mycolicibacterium
fortuitum)
no annotation 3 THR A  94
PRO A  98
PRO A  95
None
0.89A 2d55C-5k21A:
undetectable
2d55C-5k21A:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlg RENIN

(Rattus
norvegicus)
no annotation 3 THR A 350
PRO A 352
PRO A 349
None
0.87A 2d55C-5mlgA:
undetectable
2d55C-5mlgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ntf AMINOPEPTIDASE

(Trypanosoma
cruzi)
PF00883
(Peptidase_M17)
3 THR A 148
PRO A 191
PRO A 188
None
0.90A 2d55C-5ntfA:
undetectable
2d55C-5ntfA:
1.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o82 INTRACELLULAR
EXO-ALPHA-(1->5)-L-A
RABINOFURANOSIDASE


(Chaetomium
thermophilum)
no annotation 3 THR A 220
PRO A 222
PRO A 219
None
0.88A 2d55C-5o82A:
undetectable
2d55C-5o82A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5the UNCHARACTERIZED
PROTEIN


(Vanderwaltozyma
polyspora)
no annotation 3 THR A 869
PRO A 871
PRO A 834
None
0.69A 2d55C-5theA:
undetectable
2d55C-5theA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uld TRANSPORTER, NADC
FAMILY


(Vibrio cholerae)
PF00939
(Na_sulph_symp)
3 THR A 421
PRO A 418
PRO A 423
CIT  A 503 (-3.1A)
None
None
0.74A 2d55C-5uldA:
undetectable
2d55C-5uldA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v0r UBIQUITIN-CONJUGATIN
G ENZYME


(Naegleria
fowleri)
PF00179
(UQ_con)
3 THR A  76
PRO A  78
PRO A 109
None
0.90A 2d55C-5v0rA:
undetectable
2d55C-5v0rA:
6.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfa NAD-REDUCING
HYDROGENASE


(Hydrogenophilus
thermoluteolus)
PF01257
(2Fe-2S_thioredx)
PF01512
(Complex1_51K)
PF10589
(NADH_4Fe-4S)
3 THR A 342
PRO A 340
PRO A 349
None
0.77A 2d55C-5xfaA:
undetectable
2d55C-5xfaA:
2.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fe1 CARBONIC ANHYDRASE 9

(Homo sapiens)
no annotation 3 THR A 248
PRO A 250
PRO A  30
None
0.72A 2d55C-6fe1A:
undetectable
2d55C-6fe1A:
undetectable