SIMILAR PATTERNS OF AMINO ACIDS FOR 2CPP_A_CAMA422_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cby DELTA-ENDOTOXIN CYTB

(Bacillus
thuringiensis) 		PF01338
(Bac_thur_toxin) 		4 TYR A 213
THR A 165
VAL A 202
ASP A 196
 None
 1.06A 2cppA-1cbyA:
0.0		 2cppA-1cbyA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cf2 PROTEIN
(GLYCERALDEHYDE-3-PH
OSPHATE
DEHYDROGENASE)

(Methanothermus
fervidus) 		no annotation 4 THR P 208
LEU P 202
VAL P 198
VAL P 223
 None
 1.04A 2cppA-1cf2P:
undetectable		 2cppA-1cf2P:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gju MALTODEXTRIN
GLYCOSYLTRANSFERASE

(Thermotoga
maritima) 		PF00128
(Alpha-amylase)
PF09083
(DUF1923) 		4 TYR A 373
VAL A 142
VAL A 180
ASP A 181
 None
 0.98A 2cppA-1gjuA:
0.0		 2cppA-1gjuA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyh L-2-HYDROXYISOCAPROA
TE DEHYDROGENASE

(Weissella
confusa) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 THR A  96
LEU A  40
VAL A  36
VAL A 139
 None
 1.05A 2cppA-1hyhA:
0.0		 2cppA-1hyhA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lfp HYPOTHETICAL PROTEIN
AQ_1575

(Aquifex
aeolicus) 		PF01709
(Transcrip_reg) 		4 PHE A 117
LEU A 222
VAL A 234
VAL A 130
 None
 0.90A 2cppA-1lfpA:
undetectable		 2cppA-1lfpA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qnl ALIPHATIC AMIDASE
EXPRESSION-REGULATIN
G PROTEIN

(Pseudomonas
aeruginosa) 		PF13433
(Peripla_BP_5) 		4 THR A  51
LEU A  38
VAL A  35
VAL A  80
 None
 1.00A 2cppA-1qnlA:
0.0		 2cppA-1qnlA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rvk ISOMERASE/LACTONIZIN
G ENZYME

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 THR A 100
LEU A  70
VAL A  66
ASP A 105
 None
 0.87A 2cppA-1rvkA:
0.0		 2cppA-1rvkA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vdc NADPH DEPENDENT
THIOREDOXIN
REDUCTASE

(Arabidopsis
thaliana) 		PF07992
(Pyr_redox_2) 		4 PHE A 251
THR A 249
VAL A 287
VAL A 256
 FAD  A 400 ( 3.7A)
None
None
None
 1.07A 2cppA-1vdcA:
0.0		 2cppA-1vdcA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpe PHOSPHOGLYCERATE
KINASE

(Thermotoga
maritima) 		PF00162
(PGK) 		4 THR A 313
LEU A 178
VAL A 181
VAL A 191
 None
 0.78A 2cppA-1vpeA:
0.0		 2cppA-1vpeA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1

(Thermus
thermophilus) 		PF02347
(GDC-P) 		4 PHE A 415
LEU A 393
VAL A 389
VAL A 363
 None
 1.08A 2cppA-1wytA:
undetectable		 2cppA-1wytA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xq7 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Trypanosoma
cruzi) 		PF00160
(Pro_isomerase) 		4 THR A  34
LEU A  90
VAL A 128
ASP A  86
 None
 1.07A 2cppA-1xq7A:
undetectable		 2cppA-1xq7A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y5e MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
B

(Bacillus cereus) 		PF00994
(MoCF_biosynth) 		4 THR A  78
LEU A  97
VAL A  94
VAL A  53
 None
 1.00A 2cppA-1y5eA:
undetectable		 2cppA-1y5eA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yyr TRICHODIENE SYNTHASE

(Fusarium
sporotrichioides) 		PF06330
(TRI5) 		4 TYR A  93
LEU A 150
VAL A 138
VAL A  81
 SAZ  A 709 (-4.9A)
None
None
None
 0.93A 2cppA-1yyrA:
undetectable		 2cppA-1yyrA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aco OUTER MEMBRANE
LIPOPROTEIN BLC

(Escherichia
coli) 		PF08212
(Lipocalin_2) 		4 TYR A  39
LEU A 141
VAL A 130
VAL A 106
 None
 1.08A 2cppA-2acoA:
undetectable		 2cppA-2acoA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2awa DNA POLYMERASE III,
BETA CHAIN

(Streptococcus
pneumoniae) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		4 PHE A  11
LEU A  77
VAL A  34
VAL A  38
 None
 0.97A 2cppA-2awaA:
undetectable		 2cppA-2awaA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c47 CASEIN KINASE 1
GAMMA 2 ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		4 PHE A 130
THR A 136
LEU A 250
VAL A 142
 None
 1.02A 2cppA-2c47A:
undetectable		 2cppA-2c47A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c7b CARBOXYLESTERASE

(uncultured
archaeon) 		PF07859
(Abhydrolase_3) 		4 PHE A 120
TYR A 218
LEU A 159
VAL A 162
 None
 1.07A 2cppA-2c7bA:
undetectable		 2cppA-2c7bA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4v ISOCITRATE
DEHYDROGENASE

(Acidithiobacillus
thiooxidans) 		PF00180
(Iso_dh) 		4 THR A 213
LEU A 341
VAL A 126
VAL A 150
 None
 0.99A 2cppA-2d4vA:
undetectable		 2cppA-2d4vA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4v ISOCITRATE
DEHYDROGENASE

(Acidithiobacillus
thiooxidans) 		PF00180
(Iso_dh) 		4 THR A 314
LEU A 326
VAL A 322
VAL A 293
 None
 0.94A 2cppA-2d4vA:
undetectable		 2cppA-2d4vA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dg0 DRP35

(Staphylococcus
aureus) 		PF08450
(SGL) 		4 TYR A 227
THR A 199
LEU A 257
VAL A 248
 None
 0.95A 2cppA-2dg0A:
undetectable		 2cppA-2dg0A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ece 462AA LONG
HYPOTHETICAL
SELENIUM-BINDING
PROTEIN

(Sulfurisphaera
tokodaii) 		PF05694
(SBP56) 		4 THR A 398
LEU A 449
VAL A 447
VAL A 437
 None
 0.98A 2cppA-2eceA:
undetectable		 2cppA-2eceA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fge ZINC METALLOPROTEASE
(INSULINASE FAMILY)

(Arabidopsis
thaliana) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		4 THR A 577
LEU A 780
VAL A 776
VAL A 646
 None
 1.07A 2cppA-2fgeA:
undetectable		 2cppA-2fgeA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gf6 CONSERVED
HYPOTHETICAL PROTEIN

(Sulfolobus
solfataricus) 		PF13279
(4HBT_2) 		4 TYR A  28
THR A  17
LEU A  76
VAL A  12
 None
 1.02A 2cppA-2gf6A:
undetectable		 2cppA-2gf6A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i62 NICOTINAMIDE
N-METHYLTRANSFERASE

(Mus musculus) 		PF01234
(NNMT_PNMT_TEMT) 		4 PHE A 254
LEU A 194
VAL A 226
ASP A 198
 None
 1.02A 2cppA-2i62A:
undetectable		 2cppA-2i62A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k8d PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRB

(Methanothermobacter
thermautotrophicus) 		PF01641
(SelR) 		4 PHE A  90
LEU A 123
VAL A 114
VAL A  94
 None
 0.98A 2cppA-2k8dA:
undetectable		 2cppA-2k8dA:
17.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE

(Pseudomonas
putida) 		PF00067
(p450) 		4 PHE A  87
TYR A  96
LEU A 244
VAL A 396
 CAM  A 502 (-4.6A)
CAM  A 502 (-4.5A)
HEM  A 501 (-4.5A)
None
 0.78A 2cppA-2m56A:
67.9		 2cppA-2m56A:
99.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE

(Pseudomonas
putida) 		PF00067
(p450) 		7 PHE A  87
TYR A  96
THR A 185
LEU A 244
VAL A 247
VAL A 295
ASP A 297
 CAM  A 502 (-4.6A)
CAM  A 502 (-4.5A)
None
HEM  A 501 (-4.5A)
None
HEM  A 501 (-4.6A)
HEM  A 501 (-2.8A)
 0.26A 2cppA-2m56A:
67.9		 2cppA-2m56A:
99.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n67 HEMOLYSIN II

(Bacillus cereus) 		no annotation 4 PHE B  66
TYR B  64
LEU B  36
VAL B  16
 None
 1.05A 2cppA-2n67B:
undetectable		 2cppA-2n67B:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1b AMINOTRANSFERASE,
CLASS I

(Staphylococcus
aureus) 		PF00155
(Aminotran_1_2) 		4 PHE A 190
THR A 162
LEU A 167
VAL A 154
 None
 0.98A 2cppA-2o1bA:
undetectable		 2cppA-2o1bA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2m ACETYL-COENZYME A
SYNTHETASE

(Salmonella
enterica) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		4 TYR A 488
THR A 416
LEU A 477
VAL A 274
 None
PRX  A 998 (-3.7A)
None
None
 1.07A 2cppA-2p2mA:
undetectable		 2cppA-2p2mA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pi5 DNA-DIRECTED RNA
POLYMERASE

(Escherichia
virus T7) 		PF00940
(RNA_pol)
PF14700
(RPOL_N) 		4 THR A 630
LEU A 582
VAL A 578
VAL A 650
 None
 1.03A 2cppA-2pi5A:
undetectable		 2cppA-2pi5A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pzh HYPOTHETICAL PROTEIN
HP_0496

(Helicobacter
pylori) 		PF03061
(4HBT) 		4 TYR A  21
THR A  10
LEU A  66
VAL A   5
 None
 0.97A 2cppA-2pzhA:
undetectable		 2cppA-2pzhA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q7v THIOREDOXIN
REDUCTASE

(Deinococcus
radiodurans) 		PF07992
(Pyr_redox_2) 		4 PHE A 253
THR A 251
VAL A 285
VAL A 258
 FAD  A 348 ( 4.0A)
None
None
None
 1.05A 2cppA-2q7vA:
undetectable		 2cppA-2q7vA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uut RNA-DIRECTED RNA
POLYMERASE

(Sapporo virus) 		PF00680
(RdRP_1) 		4 THR A 357
LEU A 368
VAL A 364
VAL A 336
 None
 1.02A 2cppA-2uutA:
undetectable		 2cppA-2uutA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vl6 MINICHROMOSOME
MAINTENANCE PROTEIN
MCM

(Sulfolobus
solfataricus) 		PF14551
(MCM_N)
PF17207
(MCM_OB) 		4 THR A 234
VAL A 101
VAL A 106
ASP A 124
 None
 0.93A 2cppA-2vl6A:
undetectable		 2cppA-2vl6A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vun ENAMIDASE

(Eubacterium
barkeri) 		PF01979
(Amidohydro_1) 		4 THR A  66
VAL A 217
VAL A 247
ASP A 276
 None
None
None
ZN  A 401 (-2.9A)
 1.01A 2cppA-2vunA:
undetectable		 2cppA-2vunA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT

(Homo sapiens) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC) 		4 PHE A 198
THR A 189
LEU A 477
VAL A 174
 None
 1.07A 2cppA-2wghA:
undetectable		 2cppA-2wghA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xly CLOQ

(Streptomyces
roseochromogenus) 		PF11468
(PTase_Orf2) 		4 THR A  91
LEU A 123
VAL A 164
ASP A  96
 None
 1.04A 2cppA-2xlyA:
undetectable		 2cppA-2xlyA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yh2 ESTERASE

(Pyrobaculum
calidifontis) 		PF07859
(Abhydrolase_3) 		4 PHE A 123
TYR A 221
LEU A 162
VAL A 165
 None
 1.06A 2cppA-2yh2A:
undetectable		 2cppA-2yh2A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zhp BLEOMYCIN RESISTANCE
PROTEIN

(Streptoalloteichus
hindustanus) 		no annotation 4 PHE A  29
LEU A 108
VAL A 116
VAL A  68
 None
 1.05A 2cppA-2zhpA:
undetectable		 2cppA-2zhpA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ail 303AA LONG
HYPOTHETICAL
ESTERASE

(Sulfurisphaera
tokodaii) 		PF07859
(Abhydrolase_3) 		4 PHE A 117
TYR A 210
LEU A 155
VAL A 158
 None
 1.04A 2cppA-3ailA:
undetectable		 2cppA-3ailA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3awk CHALCONE
SYNTHASE-LIKE
POLYKETIDE SYNTHASE

(Huperzia
serrata) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 THR A 391
LEU A 257
VAL A 292
VAL A 312
 None
 1.03A 2cppA-3awkA:
undetectable		 2cppA-3awkA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9t TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN

(Methylobacillus
flagellatus) 		PF03069
(FmdA_AmdA) 		4 TYR A 227
LEU A 279
VAL A 278
VAL A 223
 None
 0.93A 2cppA-3b9tA:
undetectable		 2cppA-3b9tA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clm TRANSALDOLASE

(Neisseria
gonorrhoeae) 		PF00923
(TAL_FSA) 		4 THR A 119
LEU A 161
VAL A 139
ASP A 147
 None
 0.86A 2cppA-3clmA:
undetectable		 2cppA-3clmA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cn7 CARBOXYLESTERASE

(Pseudomonas
aeruginosa) 		PF02230
(Abhydrolase_2) 		4 PHE A  45
THR A  43
LEU A 135
VAL A  39
 None
 0.82A 2cppA-3cn7A:
undetectable		 2cppA-3cn7A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cty THIOREDOXIN
REDUCTASE

(Thermoplasma
acidophilum) 		PF07992
(Pyr_redox_2) 		4 PHE A 256
THR A 254
VAL A 289
VAL A 262
 FAD  A1000 (-3.9A)
None
None
None
 1.03A 2cppA-3ctyA:
undetectable		 2cppA-3ctyA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g05 TRNA URIDINE
5-CARBOXYMETHYLAMINO
METHYL MODIFICATION
ENZYME MNMG

(Escherichia
coli) 		PF01134
(GIDA)
PF13932
(GIDA_assoc) 		4 LEU A 365
VAL A 151
VAL A 125
ASP A 127
 None
 0.98A 2cppA-3g05A:
undetectable		 2cppA-3g05A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Aquifex
aeolicus) 		PF01425
(Amidase) 		4 PHE A  92
TYR A 322
THR A  82
VAL A 197
 None
 1.05A 2cppA-3h0lA:
undetectable		 2cppA-3h0lA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hm0 PROBABLE
THIOESTERASE

(Bartonella
henselae) 		PF03061
(4HBT) 		4 TYR A  38
THR A  27
LEU A  90
VAL A  22
 None
 1.03A 2cppA-3hm0A:
undetectable		 2cppA-3hm0A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ko7 D-TYROSYL-TRNA(TYR)
DEACYLASE

(Plasmodium
falciparum) 		PF02580
(Tyr_Deacylase) 		4 LEU A  79
VAL A  76
VAL A 151
ASP A 148
 None
 1.02A 2cppA-3ko7A:
undetectable		 2cppA-3ko7A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm3 UNCHARACTERIZED
PROTEIN

(Parabacteroides
distasonis) 		PF12979
(DUF3863)
PF12980
(DUF3864) 		4 THR A 338
LEU A  53
VAL A  51
VAL A 290
 None
 0.94A 2cppA-3lm3A:
undetectable		 2cppA-3lm3A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mbt OUTER MEMBRANE
LIPOPROTEIN BLC

(Escherichia
coli) 		PF08212
(Lipocalin_2) 		4 TYR A  21
LEU A 123
VAL A 112
VAL A  88
 None
 1.05A 2cppA-3mbtA:
undetectable		 2cppA-3mbtA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n05 NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Streptomyces
avermitilis) 		PF00795
(CN_hydrolase)
PF02540
(NAD_synthase) 		4 THR A 213
LEU A 199
VAL A 202
ASP A 235
 None
 0.89A 2cppA-3n05A:
undetectable		 2cppA-3n05A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvl MYOSIN VIIA ISOFORM
1

(Mus musculus) 		PF00784
(MyTH4) 		4 PHE A1532
LEU A1511
VAL A1498
VAL A1489
 None
None
None
GOL  A   1 ( 4.7A)
 0.96A 2cppA-3pvlA:
undetectable		 2cppA-3pvlA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqz PUTATIVE
HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Streptococcus
mutans) 		PF00195
(Chal_sti_synt_N)
PF08540
(HMG_CoA_synt_C) 		4 LEU A  95
VAL A  92
VAL A  82
ASP A  50
 None
 1.01A 2cppA-3sqzA:
undetectable		 2cppA-3sqzA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6g SH2
DOMAIN-CONTAINING
PROTEIN 3C

(Homo sapiens) 		PF00617
(RasGEF) 		4 PHE A 586
LEU A 590
VAL A 444
ASP A 441
 None
 0.94A 2cppA-3t6gA:
undetectable		 2cppA-3t6gA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tov GLYCOSYL TRANSFERASE
FAMILY 9

(Veillonella
parvula) 		PF01075
(Glyco_transf_9) 		4 LEU A 249
VAL A  49
VAL A  61
ASP A  43
 None
 0.97A 2cppA-3tovA:
undetectable		 2cppA-3tovA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umf ADENYLATE KINASE

(Schistosoma
mansoni) 		PF00406
(ADK) 		4 PHE A  13
TYR A  96
LEU A  74
VAL A 110
 None
 0.83A 2cppA-3umfA:
undetectable		 2cppA-3umfA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wev L-LYSINE 6-OXIDASE

(Marinomonas
mediterranea) 		no annotation 4 TYR A 291
THR A 408
VAL A 270
ASP A 298
 None
 0.90A 2cppA-3wevA:
undetectable		 2cppA-3wevA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wgk CELL DIVISION
PROTEIN FTSZ

(Staphylococcus
aureus) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		4 THR A 294
LEU A 300
VAL A 203
ASP A 199
 None
 0.78A 2cppA-3wgkA:
undetectable		 2cppA-3wgkA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bkm PYRIDOXAL PHOSPHATE
PHOSPHATASE,
PHOSPHOGLYCOLATE
PHOSPHATASE,
PYRIDOXAL PHOSPHATE
PHOSPHATASE

(Mus musculus) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 THR A 262
LEU A  12
VAL A  15
VAL A  22
 None
 0.88A 2cppA-4bkmA:
undetectable		 2cppA-4bkmA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bkm PYRIDOXAL PHOSPHATE
PHOSPHATASE,
PHOSPHOGLYCOLATE
PHOSPHATASE,
PYRIDOXAL PHOSPHATE
PHOSPHATASE

(Mus musculus) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 THR A 262
LEU A  12
VAL A  15
VAL A 245
 None
 1.03A 2cppA-4bkmA:
undetectable		 2cppA-4bkmA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bx0 PYRIDOXAL PHOSPHATE
PHOSPHATASE

(Mus musculus) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 THR A 249
LEU A  12
VAL A  15
VAL A  22
 None
 0.76A 2cppA-4bx0A:
undetectable		 2cppA-4bx0A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bx0 PYRIDOXAL PHOSPHATE
PHOSPHATASE

(Mus musculus) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 THR A 249
LEU A  12
VAL A  15
VAL A 232
 None
 1.01A 2cppA-4bx0A:
undetectable		 2cppA-4bx0A:
21.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c9m CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		5 TYR A  98
THR A 187
LEU A 252
VAL A 303
ASP A 305
 None
None
HEM  A1418 (-4.0A)
GOL  A1419 (-3.9A)
HEM  A1418 (-2.7A)
 0.56A 2cppA-4c9mA:
58.8		 2cppA-4c9mA:
44.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dji PROBABLE
GLUTAMATE/GAMMA-AMIN
OBUTYRATE ANTIPORTER

(Escherichia
coli) 		PF13520
(AA_permease_2) 		4 PHE A  18
TYR A 234
THR A  22
VAL A 217
 None
 0.98A 2cppA-4djiA:
undetectable		 2cppA-4djiA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ehc PE-PGRS FAMILY
PROTEIN

(Mycobacterium
tuberculosis) 		no annotation 4 PHE A 153
LEU A  35
VAL A  21
VAL A  79
 None
 1.01A 2cppA-4ehcA:
undetectable		 2cppA-4ehcA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hdt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Mycolicibacterium
thermoresistibile) 		PF16113
(ECH_2) 		4 PHE A 172
LEU A 153
VAL A 118
VAL A 129
 None
 1.06A 2cppA-4hdtA:
undetectable		 2cppA-4hdtA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 1

(Lactobacillus
brevis) 		PF00005
(ABC_tran) 		4 THR B 198
LEU B  28
VAL B  30
VAL B  87
 None
 1.03A 2cppA-4hzuB:
undetectable		 2cppA-4hzuB:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1u DEPHOSPHO-COA KINASE

(Burkholderia
vietnamiensis) 		PF01121
(CoaE) 		4 THR A   7
VAL A 115
VAL A 172
ASP A 131
 None
 1.04A 2cppA-4i1uA:
undetectable		 2cppA-4i1uA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i4j ACP-POLYENE
THIOESTERASE

(Streptomyces
globisporus) 		PF13279
(4HBT_2) 		4 TYR A  31
THR A  20
LEU A  79
VAL A  15
 None
 0.97A 2cppA-4i4jA:
undetectable		 2cppA-4i4jA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 PHE A 688
THR A 720
LEU A 752
VAL A 751
 None
 1.06A 2cppA-4k33A:
undetectable		 2cppA-4k33A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7w PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Leptotrichia
buccalis) 		PF01048
(PNP_UDP_1) 		4 THR A 199
LEU A 177
VAL A 154
VAL A 135
 None
 0.94A 2cppA-4m7wA:
undetectable		 2cppA-4m7wA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5j UNCHARACTERIZED
PROTEIN

(Helicobacter
pylori) 		no annotation 4 THR A 211
LEU A 205
VAL A 109
ASP A 144
 None
 1.06A 2cppA-4o5jA:
undetectable		 2cppA-4o5jA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4std SCYTALONE
DEHYDRATASE

(Magnaporthe
grisea) 		PF02982
(Scytalone_dh) 		4 PHE A  53
TYR A  50
VAL A  75
VAL A 108
 None
BFS  A 173 (-4.3A)
BFS  A 173 (-4.5A)
BFS  A 173 ( 4.4A)
 1.07A 2cppA-4stdA:
undetectable		 2cppA-4stdA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wy8 ESTERASE

(Rhizomucor
miehei) 		PF07859
(Abhydrolase_3) 		4 PHE A 128
TYR A 225
LEU A 169
VAL A 172
 None
 0.99A 2cppA-4wy8A:
undetectable		 2cppA-4wy8A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y5j MINI SPINDLES TOG3

(Drosophila
melanogaster) 		no annotation 4 PHE A 701
THR A 673
LEU A 645
VAL A 663
 None
 1.07A 2cppA-4y5jA:
undetectable		 2cppA-4y5jA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y96 TRIOSEPHOSPHATE
ISOMERASE

(Gemmata
obscuriglobus) 		PF00121
(TIM) 		4 PHE A 163
TYR A 202
VAL A 151
VAL A 117
 None
 0.95A 2cppA-4y96A:
undetectable		 2cppA-4y96A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymw ABC-TYPE POLAR AMINO
ACID TRANSPORT
SYSTEM, ATPASE
COMPONENT

(Caldanaerobacter
subterraneus) 		no annotation 4 THR J 188
LEU J  22
VAL J  24
VAL J  79
 None
 0.89A 2cppA-4ymwJ:
undetectable		 2cppA-4ymwJ:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypv EST8

(Parvibaculum) 		PF07859
(Abhydrolase_3) 		4 PHE A 125
TYR A 220
LEU A 164
VAL A 167
 None
 1.01A 2cppA-4ypvA:
undetectable		 2cppA-4ypvA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoh PUTATIVE
OXIDOREDUCTASE
MOLYBDOPTERIN-BINDIN
G SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 TYR A 522
THR A 537
LEU A 460
VAL A 542
 None
 1.03A 2cppA-4zohA:
undetectable		 2cppA-4zohA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2r ANGIOTENSIN-CONVERTI
NG ENZYME

(Drosophila
melanogaster) 		PF01401
(Peptidase_M2) 		4 PHE A 363
LEU A 433
VAL A 283
ASP A 360
 None
 1.00A 2cppA-5a2rA:
undetectable		 2cppA-5a2rA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cay ENVELOPE
GLYCOPROTEIN GP120
CORE FROM ST STRAIN
OF HIV-2

(Human
immunodeficiency
virus 2) 		PF00516
(GP120) 		4 PHE G 482
LEU G 301
VAL G 357
VAL G 412
 None
 0.99A 2cppA-5cayG:
undetectable		 2cppA-5cayG:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5de0 DEFERROCHELATASE

(Vibrio cholerae) 		PF04261
(Dyp_perox) 		4 THR A  91
LEU A  21
VAL A 125
VAL A 173
 None
 0.71A 2cppA-5de0A:
undetectable		 2cppA-5de0A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5du9 CDA PEPTIDE
SYNTHETASE I

(Streptomyces
coelicolor) 		PF00668
(Condensation) 		4 PHE A 344
TYR A 209
THR A 217
ASP A 348
 None
 0.98A 2cppA-5du9A:
undetectable		 2cppA-5du9A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f5v PRP38

(Chaetomium
thermophilum) 		PF03371
(PRP38) 		4 TYR A 105
LEU A 119
VAL A  65
VAL A  56
 None
 0.99A 2cppA-5f5vA:
undetectable		 2cppA-5f5vA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gte LACHRYMATORY-FACTOR
SYNTHASE

(Allium cepa) 		PF10604
(Polyketide_cyc2) 		4 PHE A 104
TYR A 114
LEU A 152
VAL A  73
 None
 0.86A 2cppA-5gteA:
undetectable		 2cppA-5gteA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k53 ALDEHYDE
DEFORMYLATING
OXYGENASE

(Oscillatoria
sp.) 		PF11266
(Ald_deCOase) 		4 TYR A  17
LEU A  74
VAL A  76
VAL A  28
 None
None
None
STE  A 502 ( 4.8A)
 1.05A 2cppA-5k53A:
undetectable		 2cppA-5k53A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldd MON1
CCZ1

(Chaetomium
thermophilum;
Chaetomium
thermophilum) 		PF03164
(Mon1)
PF08217
(DUF1712) 		4 PHE B 114
LEU A 226
VAL A 287
VAL A 274
 None
 1.00A 2cppA-5lddB:
undetectable		 2cppA-5lddB:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lgd PLATELET
GLYCOPROTEIN 4

(Homo sapiens) 		PF01130
(CD36) 		5 PHE A 122
TYR A  93
THR A 130
LEU A 179
VAL A 128
 None
None
NAG  A 507 ( 4.7A)
None
None
 1.44A 2cppA-5lgdA:
undetectable		 2cppA-5lgdA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lmx DNA-DIRECTED RNA
POLYMERASES I AND
III SUBUNIT
RPAC1,DNA-DIRECTED
RNA POLYMERASES I
AND III SUBUNIT
RPAC1

(Saccharomyces
cerevisiae) 		PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L) 		4 PHE C 251
LEU C 280
VAL C 289
ASP C 273
 PHE  C 251 ( 1.3A)
LEU  C 280 ( 0.5A)
VAL  C 289 ( 0.5A)
ASP  C 273 ( 0.6A)
 0.98A 2cppA-5lmxC:
undetectable		 2cppA-5lmxC:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nil MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Escherichia
coli) 		PF00005
(ABC_tran)
PF02687
(FtsX)
PF12704
(MacB_PCD) 		4 LEU J 358
VAL J 365
VAL J 449
ASP J 405
 None
 1.05A 2cppA-5nilJ:
undetectable		 2cppA-5nilJ:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sy7 NEURONAL PAS
DOMAIN-CONTAINING
PROTEIN 3

(Mus musculus) 		PF00010
(HLH)
PF00989
(PAS)
PF08447
(PAS_3) 		4 PHE B 176
LEU B 187
VAL B 183
VAL B 318
 None
 1.07A 2cppA-5sy7B:
undetectable		 2cppA-5sy7B:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t06 ACYL-COA THIOESTER
HYDROLASE YBGC

(Escherichia
coli) 		PF03061
(4HBT) 		4 TYR A  28
THR A  17
LEU A  76
VAL A  12
 None
 0.95A 2cppA-5t06A:
undetectable		 2cppA-5t06A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT

(Homo sapiens) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		4 PHE A 198
THR A 189
LEU A 477
VAL A 174
 None
 1.06A 2cppA-5tusA:
undetectable		 2cppA-5tusA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uam ULVAN LYASE-PL25

(Pseudoalteromonas
sp. PLSV) 		PF15892
(BNR_4) 		4 THR A 318
LEU A 307
VAL A 309
VAL A 259
 None
 0.94A 2cppA-5uamA:
undetectable		 2cppA-5uamA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v10 UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF03061
(4HBT) 		4 TYR A  32
THR A  21
LEU A  80
VAL A  16
 None
 1.05A 2cppA-5v10A:
undetectable		 2cppA-5v10A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v36 GLUTATHIONE
REDUCTASE

(Streptococcus
mutans) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 PHE A 270
THR A 267
VAL A 304
VAL A 277
 FAD  A 501 ( 4.2A)
None
None
None
 0.96A 2cppA-5v36A:
undetectable		 2cppA-5v36A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yk2 PROBABLE CONSERVED
ATP-BINDING PROTEIN
ABC TRANSPORTER

(Mycobacterium
tuberculosis) 		no annotation 4 PHE A 130
LEU A 119
VAL A 239
VAL A 154
 None
 1.06A 2cppA-5yk2A:
undetectable		 2cppA-5yk2A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT C

(Pyrococcus
furiosus) 		no annotation 4 THR G  97
LEU G  33
VAL G  30
VAL G 109
 None
 0.91A 2cppA-6cfwG:
undetectable		 2cppA-6cfwG:
undetectable