SIMILAR PATTERNS OF AMINO ACIDS FOR 2COJ_B_GBNB420
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a3g | BRANCHED-CHAIN AMINOACIDAMINOTRANSFERASE (Escherichiacoli) |
PF01063(Aminotran_4) | 5 | TYR A 95ARG A 97GLY A 256THR A 257ALA A 258 | NoneNonePLP A 413 ( 3.9A)PLP A 413 (-3.4A)None | 0.33A | 2cojA-1a3gA:29.62cojB-1a3gA:29.7 | 2cojA-1a3gA:29.312cojB-1a3gA:29.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a4s | BETAINE ALDEHYDEDEHYDROGENASE (Gadus morhua) |
PF00171(Aldedh) | 5 | VAL A 296TYR A 453GLY A 450THR A 451ALA A 429 | None | 1.45A | 2cojA-1a4sA:undetectable2cojB-1a4sA:undetectable | 2cojA-1a4sA:21.362cojB-1a4sA:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dlc | DELTA-ENDOTOXINCRYIIIA (Bacillusthuringiensis) |
PF00555(Endotoxin_M)PF03944(Endotoxin_C)PF03945(Endotoxin_N) | 5 | TYR A 291THR A 297GLY A 534THR A 533ALA A 281 | None | 1.31A | 2cojA-1dlcA:undetectable2cojB-1dlcA:undetectable | 2cojA-1dlcA:22.092cojB-1dlcA:22.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dlc | DELTA-ENDOTOXINCRYIIIA (Bacillusthuringiensis) |
PF00555(Endotoxin_M)PF03944(Endotoxin_C)PF03945(Endotoxin_N) | 5 | VAL A 80THR A 297GLY A 534THR A 533ALA A 281 | None | 1.39A | 2cojA-1dlcA:undetectable2cojB-1dlcA:undetectable | 2cojA-1dlcA:22.092cojB-1dlcA:22.09 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1kt8 | BRANCHED-CHAIN AMINOACIDAMINOTRANSFERASE,MITOCHONDRIAL (Homo sapiens) |
PF01063(Aminotran_4) | 6 | TYR A 141ARG A 143MET A 241GLY A 312THR A 313ALA A 314 | ILP A 400 (-4.5A)NoneNoneILP A 400 (-3.5A)ILP A 400 (-3.6A)ILP A 400 ( 4.7A) | 0.47A | 2cojA-1kt8A:52.92cojB-1kt8A:52.4 | 2cojA-1kt8A:55.962cojB-1kt8A:55.96 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1kt8 | BRANCHED-CHAIN AMINOACIDAMINOTRANSFERASE,MITOCHONDRIAL (Homo sapiens) |
PF01063(Aminotran_4) | 5 | TYR A 141ARG A 143THR A 240MET A 241GLY A 312 | ILP A 400 (-4.5A)NoneILP A 400 (-3.9A)NoneILP A 400 (-3.5A) | 0.82A | 2cojA-1kt8A:52.92cojB-1kt8A:52.4 | 2cojA-1kt8A:55.962cojB-1kt8A:55.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ouo | NUCLEASE (Vibriovulnificus) |
PF04231(Endonuclease_1) | 5 | TYR A 43ARG A 130THR A 173GLY A 168ALA A 166 | None | 1.39A | 2cojA-1ouoA:undetectable2cojB-1ouoA:undetectable | 2cojA-1ouoA:16.762cojB-1ouoA:16.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u0s | CHEMOTAXIS PROTEINCHEY (Thermotogamaritima) |
PF00072(Response_reg) | 5 | VAL Y 5THR Y 52MET Y 53THR Y 34ALA Y 33 | None | 1.17A | 2cojA-1u0sY:undetectable2cojB-1u0sY:undetectable | 2cojA-1u0sY:13.912cojB-1u0sY:13.91 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2abj | BRANCHED-CHAIN-AMINO-ACIDAMINOTRANSFERASE,CYTOSOLIC (Homo sapiens) |
PF01063(Aminotran_4) | 7 | TYR A 159ARG A 161THR A 258MET A 259GLY A 330THR A 331ALA A 332 | CBC A1401 (-4.3A)CBC A1401 ( 4.8A)CBC A1401 ( 3.8A)CBC A1401 (-3.3A)CBC A1401 ( 3.4A)PLP A 420 ( 3.6A)CBC A1401 (-3.3A) | 0.50A | 2cojA-2abjA:56.82cojB-2abjA:56.8 | 2cojA-2abjA:98.632cojB-2abjA:98.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ej0 | BRANCHED-CHAIN AMINOACIDAMINOTRANSFERASE (Thermusthermophilus) |
PF01063(Aminotran_4) | 5 | TYR A 95ARG A 97GLY A 255THR A 256ALA A 257 | NoneNonePMP A3413 (-3.5A)PMP A3413 (-3.6A)None | 0.25A | 2cojA-2ej0A:30.52cojB-2ej0A:30.8 | 2cojA-2ej0A:28.142cojB-2ej0A:28.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2evr | COG0791: CELLWALL-ASSOCIATEDHYDROLASES(INVASION-ASSOCIATEDPROTEINS) (Nostocpunctiforme) |
PF00877(NLPC_P60) | 5 | TYR A 146TYR A 64GLY A 117THR A 36ALA A 35 | None | 1.20A | 2cojA-2evrA:undetectable2cojB-2evrA:undetectable | 2cojA-2evrA:20.852cojB-2evrA:20.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fwu | SODIUM/CALCIUMEXCHANGER 1 (Canis lupus) |
PF03160(Calx-beta) | 5 | VAL A 573THR A 541GLY A 544THR A 545ALA A 546 | None | 1.12A | 2cojA-2fwuA:undetectable2cojB-2fwuA:undetectable | 2cojA-2fwuA:17.922cojB-2fwuA:17.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g7e | ENDONUCLEASE I (Vibrio cholerae) |
PF04231(Endonuclease_1) | 5 | TYR A 43ARG A 130THR A 173GLY A 168ALA A 166 | None | 1.42A | 2cojA-2g7eA:undetectable2cojB-2g7eA:undetectable | 2cojA-2g7eA:19.422cojB-2g7eA:19.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hbw | NLP/P60 PROTEIN (Trichormusvariabilis) |
PF00877(NLPC_P60) | 5 | TYR A 146TYR A 64GLY A 117THR A 36ALA A 35 | NoneUNL A 237 (-4.9A)UNL A 237 ( 3.7A)NoneUNL A 237 (-4.7A) | 1.24A | 2cojA-2hbwA:undetectable2cojB-2hbwA:undetectable | 2cojA-2hbwA:20.982cojB-2hbwA:20.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qvk | SODIUM/CALCIUMEXCHANGER 1 (Canis lupus) |
PF03160(Calx-beta) | 5 | VAL A 573THR A 541GLY A 544THR A 586ALA A 546 | None | 1.12A | 2cojA-2qvkA:undetectable2cojB-2qvkA:undetectable | 2cojA-2qvkA:19.432cojB-2qvkA:19.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a2l | HALOALKANEDEHALOGENASE (Bradyrhizobiumjaponicum) |
PF00561(Abhydrolase_1) | 5 | TYR A 242VAL A 120GLY A 105THR A 106ALA A 101 | None | 1.39A | 2cojA-3a2lA:undetectable2cojB-3a2lA:undetectable | 2cojA-3a2lA:22.252cojB-3a2lA:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3akc | CYTIDYLATE KINASE (Thermusthermophilus) |
PF02224(Cytidylate_kin) | 5 | TYR A 37VAL A 110GLY A 129THR A 130ALA A 131 | CDP A 209 (-3.9A)NoneNoneNoneNone | 1.00A | 2cojA-3akcA:undetectable2cojB-3akcA:undetectable | 2cojA-3akcA:22.052cojB-3akcA:22.05 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3dtg | BRANCHED-CHAIN AMINOACIDAMINOTRANSFERASE (Mycolicibacteriumsmegmatis) |
PF01063(Aminotran_4) | 6 | TYR A 144ARG A 146MET A 244GLY A 313THR A 314ALA A 315 | NoneOBZ A 371 (-4.2A)NonePLP A 369 (-3.6A)PLP A 369 (-3.5A)OBZ A 371 ( 4.1A) | 0.29A | 2cojA-3dtgA:45.32cojB-3dtgA:45.4 | 2cojA-3dtgA:37.532cojB-3dtgA:37.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nm1 | THIAMINEBIOSYNTHETICBIFUNCTIONAL ENZYME ([Candida]glabrata) |
PF02110(HK)PF02581(TMP-TENI) | 5 | TYR A 344TYR A 409GLY A 155THR A 156ALA A 157 | None | 1.25A | 2cojA-3nm1A:undetectable2cojB-3nm1A:undetectable | 2cojA-3nm1A:22.262cojB-3nm1A:22.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ol2 | SEMAPHORIN-4D (Homo sapiens) |
PF00047(ig)PF01403(Sema)PF01437(PSI) | 5 | VAL A 513TYR A 436GLY A 433THR A 434ALA A 430 | None | 1.40A | 2cojA-3ol2A:undetectable2cojB-3ol2A:undetectable | 2cojA-3ol2A:21.262cojB-3ol2A:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3us9 | SODIUM/CALCIUMEXCHANGER 1 (Canis lupus) |
PF03160(Calx-beta) | 5 | VAL A 573THR A 541GLY A 544THR A 586ALA A 546 | None | 1.13A | 2cojA-3us9A:undetectable2cojB-3us9A:undetectable | 2cojA-3us9A:21.722cojB-3us9A:21.72 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3uzb | BRANCHED-CHAIN-AMINO-ACIDAMINOTRANSFERASE (Deinococcusradiodurans) |
PF01063(Aminotran_4) | 5 | TYR A 143ARG A 145GLY A 303THR A 304ALA A 305 | COI A1517 (-4.8A)NonePLP A 371 (-3.6A)PLP A 371 ( 3.7A)COI A1517 (-3.1A) | 0.40A | 2cojA-3uzbA:39.72cojB-3uzbA:39.9 | 2cojA-3uzbA:32.662cojB-3uzbA:32.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wxf | UNCHARACTERIZEDPROTEIN (Danio rerio) |
PF00443(UCH) | 5 | VAL A 611ARG A 644THR A 881MET A 882GLY A 809 | None | 1.45A | 2cojA-3wxfA:undetectable2cojB-3wxfA:undetectable | 2cojA-3wxfA:22.222cojB-3wxfA:22.22 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4dqn | PUTATIVEBRANCHED-CHAIN AMINOACIDAMINOTRANSFERASEILVE (Streptococcusmutans) |
PF01063(Aminotran_4) | 5 | TYR A 124ARG A 126GLY A 284THR A 285ALA A 286 | None | 0.49A | 2cojA-4dqnA:40.02cojB-4dqnA:40.0 | 2cojA-4dqnA:33.162cojB-4dqnA:33.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4drf | METHYLTRANSFERASETYPE 12 (Ruminiclostridiumthermocellum) |
PF12623(Hen1_L) | 5 | TYR B 40VAL B 50GLY B 98THR B 99ALA B 100 | None | 0.86A | 2cojA-4drfB:undetectable2cojB-4drfB:undetectable | 2cojA-4drfB:19.742cojB-4drfB:19.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eip | PUTATIVEFAD-MONOOXYGENASE (Lechevalieriaaerocolonigenes) |
PF01494(FAD_binding_3) | 5 | VAL A 346THR A 311GLY A 295THR A 294ALA A 298 | NoneNoneFAD A 602 (-3.4A)NoneNone | 1.28A | 2cojA-4eipA:undetectable2cojB-4eipA:undetectable | 2cojA-4eipA:22.622cojB-4eipA:22.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g56 | MGC81050 PROTEIN (Xenopus laevis) |
PF00400(WD40) | 5 | VAL B 118THR B 74GLY B 46THR B 69ALA B 71 | None | 1.33A | 2cojA-4g56B:undetectable2cojB-4g56B:undetectable | 2cojA-4g56B:21.122cojB-4g56B:21.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4is4 | GLUTAMINE SYNTHETASE (Medicagotruncatula) |
PF00120(Gln-synt_C)PF03951(Gln-synt_N) | 5 | VAL A 343ARG A 218THR A 250GLY A 203ALA A 210 | None | 1.26A | 2cojA-4is4A:undetectable2cojB-4is4A:undetectable | 2cojA-4is4A:22.572cojB-4is4A:22.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jxc | FEFE-HYDROGENASEMATURASE (Thermotogamaritima) |
PF04055(Radical_SAM)PF06968(BATS) | 5 | VAL A 253THR A 282GLY A 272THR A 269ALA A 270 | NoneNoneNone CL A 414 (-4.7A) CL A 414 (-3.8A) | 1.17A | 2cojA-4jxcA:undetectable2cojB-4jxcA:undetectable | 2cojA-4jxcA:23.632cojB-4jxcA:23.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k2a | HALOALKANEDEHALOGENASE (Bradyrhizobiumelkanii) |
PF00561(Abhydrolase_1) | 5 | TYR A 233VAL A 120GLY A 105THR A 106ALA A 101 | None | 1.38A | 2cojA-4k2aA:undetectable2cojB-4k2aA:undetectable | 2cojA-4k2aA:19.952cojB-4k2aA:19.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mh0 | RAS-RELATED PROTEINRAP-1B (Homo sapiens) |
PF00071(Ras) | 5 | TYR R 32VAL R 21GLY R 60THR R 61ALA R 59 | NoneNoneNoneNoneSO4 R 201 (-3.3A) | 1.39A | 2cojA-4mh0R:undetectable2cojB-4mh0R:undetectable | 2cojA-4mh0R:16.492cojB-4mh0R:16.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ntc | GLIT (Aspergillusfumigatus) |
PF07992(Pyr_redox_2) | 5 | TYR A 81ARG A 80GLY A 31THR A 30ALA A 33 | None | 1.26A | 2cojA-4ntcA:undetectable2cojB-4ntcA:undetectable | 2cojA-4ntcA:21.772cojB-4ntcA:21.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pcs | ALPHA-L-FUCOSIDASE (Bacteroidesthetaiotaomicron) |
PF01120(Alpha_L_fucos) | 5 | TYR A 168VAL A 129THR A 126GLY A 371ALA A 367 | IMD A 503 (-4.9A)NoneNoneNoneNone | 1.34A | 2cojA-4pcsA:undetectable2cojB-4pcsA:undetectable | 2cojA-4pcsA:20.642cojB-4pcsA:20.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pcs | ALPHA-L-FUCOSIDASE (Bacteroidesthetaiotaomicron) |
PF01120(Alpha_L_fucos) | 5 | VAL A 129THR A 126GLY A 371THR A 368ALA A 367 | None | 1.46A | 2cojA-4pcsA:undetectable2cojB-4pcsA:undetectable | 2cojA-4pcsA:20.642cojB-4pcsA:20.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rep | GAMMA-CAROTENEDESATURASE (Nonlabensdokdonensis) |
PF01593(Amino_oxidase) | 5 | TYR A 192TYR A 88ARG A 188THR A 216ALA A 98 | None | 1.20A | 2cojA-4repA:undetectable2cojB-4repA:undetectable | 2cojA-4repA:23.482cojB-4repA:23.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ts6 | RAB3 INTERACTINGMOLECULE VARIANT 2 (Drosophilamelanogaster) |
PF00168(C2) | 5 | VAL A 897THR A 900GLY A 864THR A 863ALA A 862 | None | 1.32A | 2cojA-4ts6A:undetectable2cojB-4ts6A:undetectable | 2cojA-4ts6A:17.022cojB-4ts6A:17.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4whx | BRANCHED-CHAIN-AMINO-ACID TRANSAMINASE (Burkholderiapseudomallei) |
PF01063(Aminotran_4) | 5 | TYR A 98ARG A 100GLY A 257THR A 258ALA A 259 | ALA A 401 (-4.3A)ALA A 401 ( 4.6A)LLP A 161 ( 3.4A)LLP A 161 (-3.6A)ALA A 401 (-3.4A) | 0.43A | 2cojA-4whxA:31.12cojB-4whxA:31.4 | 2cojA-4whxA:26.492cojB-4whxA:26.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wjm | RIBOKINASE:CARBOHYDRATE KINASE, PFKB (Brucellaabortus) |
PF00294(PfkB) | 5 | VAL A 241THR A 244GLY A 248THR A 250ALA A 289 | ANP A 401 (-4.9A)ANP A 401 (-4.3A)ANP A 401 (-3.4A)NoneANP A 401 (-3.5A) | 1.35A | 2cojA-4wjmA:undetectable2cojB-4wjmA:undetectable | 2cojA-4wjmA:20.202cojB-4wjmA:20.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x28 | ACYL-COADEHYDROGENASE (Mycobacteriumtuberculosis) |
no annotation | 5 | VAL D 289THR D 223GLY D 311THR D 309ALA D 310 | None | 1.49A | 2cojA-4x28D:undetectable2cojB-4x28D:undetectable | 2cojA-4x28D:21.902cojB-4x28D:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ce8 | BRANCHED-CHAIN AMINOACIDAMINOTRANSFERASE (Thermoproteusuzoniensis) |
PF01063(Aminotran_4) | 5 | TYR A 91ARG A 93GLY A 247THR A 248ALA A 249 | NoneNonePLP A 301 ( 3.7A)PLP A 301 (-3.5A)None | 0.37A | 2cojA-5ce8A:31.42cojB-5ce8A:31.5 | 2cojA-5ce8A:25.002cojB-5ce8A:25.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5czw | MYROILYSIN (Myroidesprofundi) |
PF01400(Astacin) | 5 | TYR A 107VAL A 31TYR A 175GLY A 125ALA A 102 | None | 1.23A | 2cojA-5czwA:undetectable2cojB-5czwA:undetectable | 2cojA-5czwA:19.032cojB-5czwA:19.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5czw | MYROILYSIN (Myroidesprofundi) |
PF01400(Astacin) | 5 | TYR A 107VAL A 31TYR A 175GLY A 125THR A 99 | None | 1.34A | 2cojA-5czwA:undetectable2cojB-5czwA:undetectable | 2cojA-5czwA:19.032cojB-5czwA:19.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dn6 | ATP SYNTHASE SUBUNITALPHA (Paracoccusdenitrificans) |
PF00006(ATP-synt_ab)PF00306(ATP-synt_ab_C)PF02874(ATP-synt_ab_N) | 5 | VAL A 108THR A 231GLY A 255THR A 252ALA A 253 | None | 1.35A | 2cojA-5dn6A:undetectable2cojB-5dn6A:undetectable | 2cojA-5dn6A:22.812cojB-5dn6A:22.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e25 | BRANCHED-CHAINAMINOTRANSFERASE (Geoglobusacetivorans) |
PF01063(Aminotran_4) | 5 | TYR A 89ARG A 91GLY A 247THR A 248ALA A 249 | AKG A 302 (-4.3A)AKG A 302 ( 4.1A)PLP A 301 (-3.4A)PLP A 301 ( 3.7A)AKG A 302 (-3.6A) | 0.51A | 2cojA-5e25A:29.22cojB-5e25A:29.6 | 2cojA-5e25A:24.562cojB-5e25A:24.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mqz | PUTATIVEBRANCHED-CHAIN-AMINO-ACIDAMINOTRANSFERASE (Archaeoglobusfulgidus) |
no annotation | 5 | TYR A 87ARG A 89GLY A 245THR A 246ALA A 247 | NoneNoneLLP A 150 ( 3.4A)LLP A 150 ( 3.7A)None | 0.35A | 2cojA-5mqzA:28.42cojB-5mqzA:28.6 | 2cojA-5mqzA:10.782cojB-5mqzA:10.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oji | DEHYDROGENASE/REDUCTASE SDR FAMILYMEMBER 4 (Caenorhabditiselegans) |
no annotation | 5 | TYR A 152ARG A 259THR A 172THR A 166ALA A 151 | None | 1.30A | 2cojA-5ojiA:undetectable2cojB-5ojiA:undetectable | 2cojA-5ojiA:22.282cojB-5ojiA:22.28 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5u3f | BRANCHED-CHAIN-AMINO-ACIDAMINOTRANSFERASE (Mycobacteriumtuberculosis) |
PF01063(Aminotran_4) | 6 | TYR A 144ARG A 146MET A 244GLY A 313THR A 314ALA A 315 | 7TS A 400 (-4.6A)NoneNone7TS A 400 (-3.6A)7TS A 400 (-3.6A)None | 0.27A | 2cojA-5u3fA:39.92cojB-5u3fA:40.0 | 2cojA-5u3fA:36.572cojB-5u3fA:36.57 |