SIMILAR PATTERNS OF AMINO ACIDS FOR 2COJ_B_GBNB420

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a3g BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE


(Escherichia
coli)
PF01063
(Aminotran_4)
5 TYR A  95
ARG A  97
GLY A 256
THR A 257
ALA A 258
None
None
PLP  A 413 ( 3.9A)
PLP  A 413 (-3.4A)
None
0.33A 2cojA-1a3gA:
29.6
2cojB-1a3gA:
29.7
2cojA-1a3gA:
29.31
2cojB-1a3gA:
29.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a4s BETAINE ALDEHYDE
DEHYDROGENASE


(Gadus morhua)
PF00171
(Aldedh)
5 VAL A 296
TYR A 453
GLY A 450
THR A 451
ALA A 429
None
1.45A 2cojA-1a4sA:
undetectable
2cojB-1a4sA:
undetectable
2cojA-1a4sA:
21.36
2cojB-1a4sA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dlc DELTA-ENDOTOXIN
CRYIIIA


(Bacillus
thuringiensis)
PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
5 TYR A 291
THR A 297
GLY A 534
THR A 533
ALA A 281
None
1.31A 2cojA-1dlcA:
undetectable
2cojB-1dlcA:
undetectable
2cojA-1dlcA:
22.09
2cojB-1dlcA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dlc DELTA-ENDOTOXIN
CRYIIIA


(Bacillus
thuringiensis)
PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
5 VAL A  80
THR A 297
GLY A 534
THR A 533
ALA A 281
None
1.39A 2cojA-1dlcA:
undetectable
2cojB-1dlcA:
undetectable
2cojA-1dlcA:
22.09
2cojB-1dlcA:
22.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL


(Homo sapiens)
PF01063
(Aminotran_4)
6 TYR A 141
ARG A 143
MET A 241
GLY A 312
THR A 313
ALA A 314
ILP  A 400 (-4.5A)
None
None
ILP  A 400 (-3.5A)
ILP  A 400 (-3.6A)
ILP  A 400 ( 4.7A)
0.47A 2cojA-1kt8A:
52.9
2cojB-1kt8A:
52.4
2cojA-1kt8A:
55.96
2cojB-1kt8A:
55.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kt8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE,
MITOCHONDRIAL


(Homo sapiens)
PF01063
(Aminotran_4)
5 TYR A 141
ARG A 143
THR A 240
MET A 241
GLY A 312
ILP  A 400 (-4.5A)
None
ILP  A 400 (-3.9A)
None
ILP  A 400 (-3.5A)
0.82A 2cojA-1kt8A:
52.9
2cojB-1kt8A:
52.4
2cojA-1kt8A:
55.96
2cojB-1kt8A:
55.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ouo NUCLEASE

(Vibrio
vulnificus)
PF04231
(Endonuclease_1)
5 TYR A  43
ARG A 130
THR A 173
GLY A 168
ALA A 166
None
1.39A 2cojA-1ouoA:
undetectable
2cojB-1ouoA:
undetectable
2cojA-1ouoA:
16.76
2cojB-1ouoA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0s CHEMOTAXIS PROTEIN
CHEY


(Thermotoga
maritima)
PF00072
(Response_reg)
5 VAL Y   5
THR Y  52
MET Y  53
THR Y  34
ALA Y  33
None
1.17A 2cojA-1u0sY:
undetectable
2cojB-1u0sY:
undetectable
2cojA-1u0sY:
13.91
2cojB-1u0sY:
13.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC


(Homo sapiens)
PF01063
(Aminotran_4)
7 TYR A 159
ARG A 161
THR A 258
MET A 259
GLY A 330
THR A 331
ALA A 332
CBC  A1401 (-4.3A)
CBC  A1401 ( 4.8A)
CBC  A1401 ( 3.8A)
CBC  A1401 (-3.3A)
CBC  A1401 ( 3.4A)
PLP  A 420 ( 3.6A)
CBC  A1401 (-3.3A)
0.50A 2cojA-2abjA:
56.8
2cojB-2abjA:
56.8
2cojA-2abjA:
98.63
2cojB-2abjA:
98.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ej0 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE


(Thermus
thermophilus)
PF01063
(Aminotran_4)
5 TYR A  95
ARG A  97
GLY A 255
THR A 256
ALA A 257
None
None
PMP  A3413 (-3.5A)
PMP  A3413 (-3.6A)
None
0.25A 2cojA-2ej0A:
30.5
2cojB-2ej0A:
30.8
2cojA-2ej0A:
28.14
2cojB-2ej0A:
28.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2evr COG0791: CELL
WALL-ASSOCIATED
HYDROLASES
(INVASION-ASSOCIATED
PROTEINS)


(Nostoc
punctiforme)
PF00877
(NLPC_P60)
5 TYR A 146
TYR A  64
GLY A 117
THR A  36
ALA A  35
None
1.20A 2cojA-2evrA:
undetectable
2cojB-2evrA:
undetectable
2cojA-2evrA:
20.85
2cojB-2evrA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fwu SODIUM/CALCIUM
EXCHANGER 1


(Canis lupus)
PF03160
(Calx-beta)
5 VAL A 573
THR A 541
GLY A 544
THR A 545
ALA A 546
None
1.12A 2cojA-2fwuA:
undetectable
2cojB-2fwuA:
undetectable
2cojA-2fwuA:
17.92
2cojB-2fwuA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g7e ENDONUCLEASE I

(Vibrio cholerae)
PF04231
(Endonuclease_1)
5 TYR A  43
ARG A 130
THR A 173
GLY A 168
ALA A 166
None
1.42A 2cojA-2g7eA:
undetectable
2cojB-2g7eA:
undetectable
2cojA-2g7eA:
19.42
2cojB-2g7eA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hbw NLP/P60 PROTEIN

(Trichormus
variabilis)
PF00877
(NLPC_P60)
5 TYR A 146
TYR A  64
GLY A 117
THR A  36
ALA A  35
None
UNL  A 237 (-4.9A)
UNL  A 237 ( 3.7A)
None
UNL  A 237 (-4.7A)
1.24A 2cojA-2hbwA:
undetectable
2cojB-2hbwA:
undetectable
2cojA-2hbwA:
20.98
2cojB-2hbwA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvk SODIUM/CALCIUM
EXCHANGER 1


(Canis lupus)
PF03160
(Calx-beta)
5 VAL A 573
THR A 541
GLY A 544
THR A 586
ALA A 546
None
1.12A 2cojA-2qvkA:
undetectable
2cojB-2qvkA:
undetectable
2cojA-2qvkA:
19.43
2cojB-2qvkA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2l HALOALKANE
DEHALOGENASE


(Bradyrhizobium
japonicum)
PF00561
(Abhydrolase_1)
5 TYR A 242
VAL A 120
GLY A 105
THR A 106
ALA A 101
None
1.39A 2cojA-3a2lA:
undetectable
2cojB-3a2lA:
undetectable
2cojA-3a2lA:
22.25
2cojB-3a2lA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3akc CYTIDYLATE KINASE

(Thermus
thermophilus)
PF02224
(Cytidylate_kin)
5 TYR A  37
VAL A 110
GLY A 129
THR A 130
ALA A 131
CDP  A 209 (-3.9A)
None
None
None
None
1.00A 2cojA-3akcA:
undetectable
2cojB-3akcA:
undetectable
2cojA-3akcA:
22.05
2cojB-3akcA:
22.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dtg BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE


(Mycolicibacterium
smegmatis)
PF01063
(Aminotran_4)
6 TYR A 144
ARG A 146
MET A 244
GLY A 313
THR A 314
ALA A 315
None
OBZ  A 371 (-4.2A)
None
PLP  A 369 (-3.6A)
PLP  A 369 (-3.5A)
OBZ  A 371 ( 4.1A)
0.29A 2cojA-3dtgA:
45.3
2cojB-3dtgA:
45.4
2cojA-3dtgA:
37.53
2cojB-3dtgA:
37.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nm1 THIAMINE
BIOSYNTHETIC
BIFUNCTIONAL ENZYME


([Candida]
glabrata)
PF02110
(HK)
PF02581
(TMP-TENI)
5 TYR A 344
TYR A 409
GLY A 155
THR A 156
ALA A 157
None
1.25A 2cojA-3nm1A:
undetectable
2cojB-3nm1A:
undetectable
2cojA-3nm1A:
22.26
2cojB-3nm1A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ol2 SEMAPHORIN-4D

(Homo sapiens)
PF00047
(ig)
PF01403
(Sema)
PF01437
(PSI)
5 VAL A 513
TYR A 436
GLY A 433
THR A 434
ALA A 430
None
1.40A 2cojA-3ol2A:
undetectable
2cojB-3ol2A:
undetectable
2cojA-3ol2A:
21.26
2cojB-3ol2A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3us9 SODIUM/CALCIUM
EXCHANGER 1


(Canis lupus)
PF03160
(Calx-beta)
5 VAL A 573
THR A 541
GLY A 544
THR A 586
ALA A 546
None
1.13A 2cojA-3us9A:
undetectable
2cojB-3us9A:
undetectable
2cojA-3us9A:
21.72
2cojB-3us9A:
21.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uzb BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE


(Deinococcus
radiodurans)
PF01063
(Aminotran_4)
5 TYR A 143
ARG A 145
GLY A 303
THR A 304
ALA A 305
COI  A1517 (-4.8A)
None
PLP  A 371 (-3.6A)
PLP  A 371 ( 3.7A)
COI  A1517 (-3.1A)
0.40A 2cojA-3uzbA:
39.7
2cojB-3uzbA:
39.9
2cojA-3uzbA:
32.66
2cojB-3uzbA:
32.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxf UNCHARACTERIZED
PROTEIN


(Danio rerio)
PF00443
(UCH)
5 VAL A 611
ARG A 644
THR A 881
MET A 882
GLY A 809
None
1.45A 2cojA-3wxfA:
undetectable
2cojB-3wxfA:
undetectable
2cojA-3wxfA:
22.22
2cojB-3wxfA:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dqn PUTATIVE
BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
ILVE


(Streptococcus
mutans)
PF01063
(Aminotran_4)
5 TYR A 124
ARG A 126
GLY A 284
THR A 285
ALA A 286
None
0.49A 2cojA-4dqnA:
40.0
2cojB-4dqnA:
40.0
2cojA-4dqnA:
33.16
2cojB-4dqnA:
33.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4drf METHYLTRANSFERASE
TYPE 12


(Ruminiclostridium
thermocellum)
PF12623
(Hen1_L)
5 TYR B  40
VAL B  50
GLY B  98
THR B  99
ALA B 100
None
0.86A 2cojA-4drfB:
undetectable
2cojB-4drfB:
undetectable
2cojA-4drfB:
19.74
2cojB-4drfB:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eip PUTATIVE
FAD-MONOOXYGENASE


(Lechevalieria
aerocolonigenes)
PF01494
(FAD_binding_3)
5 VAL A 346
THR A 311
GLY A 295
THR A 294
ALA A 298
None
None
FAD  A 602 (-3.4A)
None
None
1.28A 2cojA-4eipA:
undetectable
2cojB-4eipA:
undetectable
2cojA-4eipA:
22.62
2cojB-4eipA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g56 MGC81050 PROTEIN

(Xenopus laevis)
PF00400
(WD40)
5 VAL B 118
THR B  74
GLY B  46
THR B  69
ALA B  71
None
1.33A 2cojA-4g56B:
undetectable
2cojB-4g56B:
undetectable
2cojA-4g56B:
21.12
2cojB-4g56B:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4is4 GLUTAMINE SYNTHETASE

(Medicago
truncatula)
PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N)
5 VAL A 343
ARG A 218
THR A 250
GLY A 203
ALA A 210
None
1.26A 2cojA-4is4A:
undetectable
2cojB-4is4A:
undetectable
2cojA-4is4A:
22.57
2cojB-4is4A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxc FEFE-HYDROGENASE
MATURASE


(Thermotoga
maritima)
PF04055
(Radical_SAM)
PF06968
(BATS)
5 VAL A 253
THR A 282
GLY A 272
THR A 269
ALA A 270
None
None
None
CL  A 414 (-4.7A)
CL  A 414 (-3.8A)
1.17A 2cojA-4jxcA:
undetectable
2cojB-4jxcA:
undetectable
2cojA-4jxcA:
23.63
2cojB-4jxcA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k2a HALOALKANE
DEHALOGENASE


(Bradyrhizobium
elkanii)
PF00561
(Abhydrolase_1)
5 TYR A 233
VAL A 120
GLY A 105
THR A 106
ALA A 101
None
1.38A 2cojA-4k2aA:
undetectable
2cojB-4k2aA:
undetectable
2cojA-4k2aA:
19.95
2cojB-4k2aA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mh0 RAS-RELATED PROTEIN
RAP-1B


(Homo sapiens)
PF00071
(Ras)
5 TYR R  32
VAL R  21
GLY R  60
THR R  61
ALA R  59
None
None
None
None
SO4  R 201 (-3.3A)
1.39A 2cojA-4mh0R:
undetectable
2cojB-4mh0R:
undetectable
2cojA-4mh0R:
16.49
2cojB-4mh0R:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ntc GLIT

(Aspergillus
fumigatus)
PF07992
(Pyr_redox_2)
5 TYR A  81
ARG A  80
GLY A  31
THR A  30
ALA A  33
None
1.26A 2cojA-4ntcA:
undetectable
2cojB-4ntcA:
undetectable
2cojA-4ntcA:
21.77
2cojB-4ntcA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pcs ALPHA-L-FUCOSIDASE

(Bacteroides
thetaiotaomicron)
PF01120
(Alpha_L_fucos)
5 TYR A 168
VAL A 129
THR A 126
GLY A 371
ALA A 367
IMD  A 503 (-4.9A)
None
None
None
None
1.34A 2cojA-4pcsA:
undetectable
2cojB-4pcsA:
undetectable
2cojA-4pcsA:
20.64
2cojB-4pcsA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pcs ALPHA-L-FUCOSIDASE

(Bacteroides
thetaiotaomicron)
PF01120
(Alpha_L_fucos)
5 VAL A 129
THR A 126
GLY A 371
THR A 368
ALA A 367
None
1.46A 2cojA-4pcsA:
undetectable
2cojB-4pcsA:
undetectable
2cojA-4pcsA:
20.64
2cojB-4pcsA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rep GAMMA-CAROTENE
DESATURASE


(Nonlabens
dokdonensis)
PF01593
(Amino_oxidase)
5 TYR A 192
TYR A  88
ARG A 188
THR A 216
ALA A  98
None
1.20A 2cojA-4repA:
undetectable
2cojB-4repA:
undetectable
2cojA-4repA:
23.48
2cojB-4repA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ts6 RAB3 INTERACTING
MOLECULE VARIANT 2


(Drosophila
melanogaster)
PF00168
(C2)
5 VAL A 897
THR A 900
GLY A 864
THR A 863
ALA A 862
None
1.32A 2cojA-4ts6A:
undetectable
2cojB-4ts6A:
undetectable
2cojA-4ts6A:
17.02
2cojB-4ts6A:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4whx BRANCHED-CHAIN-AMINO
-ACID TRANSAMINASE


(Burkholderia
pseudomallei)
PF01063
(Aminotran_4)
5 TYR A  98
ARG A 100
GLY A 257
THR A 258
ALA A 259
ALA  A 401 (-4.3A)
ALA  A 401 ( 4.6A)
LLP  A 161 ( 3.4A)
LLP  A 161 (-3.6A)
ALA  A 401 (-3.4A)
0.43A 2cojA-4whxA:
31.1
2cojB-4whxA:
31.4
2cojA-4whxA:
26.49
2cojB-4whxA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjm RIBOKINASE:CARBOHYDR
ATE KINASE, PFKB


(Brucella
abortus)
PF00294
(PfkB)
5 VAL A 241
THR A 244
GLY A 248
THR A 250
ALA A 289
ANP  A 401 (-4.9A)
ANP  A 401 (-4.3A)
ANP  A 401 (-3.4A)
None
ANP  A 401 (-3.5A)
1.35A 2cojA-4wjmA:
undetectable
2cojB-4wjmA:
undetectable
2cojA-4wjmA:
20.20
2cojB-4wjmA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x28 ACYL-COA
DEHYDROGENASE


(Mycobacterium
tuberculosis)
no annotation 5 VAL D 289
THR D 223
GLY D 311
THR D 309
ALA D 310
None
1.49A 2cojA-4x28D:
undetectable
2cojB-4x28D:
undetectable
2cojA-4x28D:
21.90
2cojB-4x28D:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ce8 BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE


(Thermoproteus
uzoniensis)
PF01063
(Aminotran_4)
5 TYR A  91
ARG A  93
GLY A 247
THR A 248
ALA A 249
None
None
PLP  A 301 ( 3.7A)
PLP  A 301 (-3.5A)
None
0.37A 2cojA-5ce8A:
31.4
2cojB-5ce8A:
31.5
2cojA-5ce8A:
25.00
2cojB-5ce8A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czw MYROILYSIN

(Myroides
profundi)
PF01400
(Astacin)
5 TYR A 107
VAL A  31
TYR A 175
GLY A 125
ALA A 102
None
1.23A 2cojA-5czwA:
undetectable
2cojB-5czwA:
undetectable
2cojA-5czwA:
19.03
2cojB-5czwA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czw MYROILYSIN

(Myroides
profundi)
PF01400
(Astacin)
5 TYR A 107
VAL A  31
TYR A 175
GLY A 125
THR A  99
None
1.34A 2cojA-5czwA:
undetectable
2cojB-5czwA:
undetectable
2cojA-5czwA:
19.03
2cojB-5czwA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dn6 ATP SYNTHASE SUBUNIT
ALPHA


(Paracoccus
denitrificans)
PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N)
5 VAL A 108
THR A 231
GLY A 255
THR A 252
ALA A 253
None
1.35A 2cojA-5dn6A:
undetectable
2cojB-5dn6A:
undetectable
2cojA-5dn6A:
22.81
2cojB-5dn6A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e25 BRANCHED-CHAIN
AMINOTRANSFERASE


(Geoglobus
acetivorans)
PF01063
(Aminotran_4)
5 TYR A  89
ARG A  91
GLY A 247
THR A 248
ALA A 249
AKG  A 302 (-4.3A)
AKG  A 302 ( 4.1A)
PLP  A 301 (-3.4A)
PLP  A 301 ( 3.7A)
AKG  A 302 (-3.6A)
0.51A 2cojA-5e25A:
29.2
2cojB-5e25A:
29.6
2cojA-5e25A:
24.56
2cojB-5e25A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqz PUTATIVE
BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE


(Archaeoglobus
fulgidus)
no annotation 5 TYR A  87
ARG A  89
GLY A 245
THR A 246
ALA A 247
None
None
LLP  A 150 ( 3.4A)
LLP  A 150 ( 3.7A)
None
0.35A 2cojA-5mqzA:
28.4
2cojB-5mqzA:
28.6
2cojA-5mqzA:
10.78
2cojB-5mqzA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oji DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 4


(Caenorhabditis
elegans)
no annotation 5 TYR A 152
ARG A 259
THR A 172
THR A 166
ALA A 151
None
1.30A 2cojA-5ojiA:
undetectable
2cojB-5ojiA:
undetectable
2cojA-5ojiA:
22.28
2cojB-5ojiA:
22.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u3f BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE


(Mycobacterium
tuberculosis)
PF01063
(Aminotran_4)
6 TYR A 144
ARG A 146
MET A 244
GLY A 313
THR A 314
ALA A 315
7TS  A 400 (-4.6A)
None
None
7TS  A 400 (-3.6A)
7TS  A 400 (-3.6A)
None
0.27A 2cojA-5u3fA:
39.9
2cojB-5u3fA:
40.0
2cojA-5u3fA:
36.57
2cojB-5u3fA:
36.57