SIMILAR PATTERNS OF AMINO ACIDS FOR 2CML_D_ZMRD4478_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0j TRYPSIN

(Salmo salar) 		PF00089
(Trypsin) 		4 SER A 145
SER A 147
SER A 148
ASN A 150
 None
 1.13A 2cmlD-1a0jA:
undetectable		 2cmlD-1a0jA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aye PROCARBOXYPEPTIDASE
A2

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		4 SER A 162
ASP A 163
SER A 164
SER A 157
 None
 1.04A 2cmlD-1ayeA:
undetectable		 2cmlD-1ayeA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cvm PHYTASE

(Bacillus
amyloliquefaciens) 		PF02333
(Phytase) 		4 SER A 283
ASP A 298
SER A 278
ASN A 281
 None
 1.10A 2cmlD-1cvmA:
14.0		 2cmlD-1cvmA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE

(Sus scrofa) 		PF01180
(DHO_dh)
PF07992
(Pyr_redox_2)
PF14691
(Fer4_20)
PF14697
(Fer4_21) 		4 SER A 558
SER A 556
SER A 557
LYS A 616
 None
 1.13A 2cmlD-1h7wA:
undetectable		 2cmlD-1h7wA:
16.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nmb N9 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 SER N 367
SER N 370
SER N 372
TRP N 403
 None
 0.62A 2cmlD-1nmbN:
70.6		 2cmlD-1nmbN:
68.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nmb N9 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 SER N 367
SER N 370
TRP N 403
LYS N 432
 None
 0.61A 2cmlD-1nmbN:
70.6		 2cmlD-1nmbN:
68.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1v0z NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		8 SER A 374
ASP A 376
SER A 377
SER A 379
ASN A 406
GLN A 407
TRP A 409
LYS A 440
 None
 0.20A 2cmlD-1v0zA:
76.3		 2cmlD-1v0zA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xog NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		6 SER A 368
SER A 371
SER A 373
ASN A 400
TRP A 403
LYS A 434
 None
 0.81A 2cmlD-1xogA:
71.6		 2cmlD-1xogA:
69.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6r MLC PROTEIN

(Escherichia
coli) 		PF00480
(ROK) 		4 SER A 270
ASP A 272
SER A 273
LYS A 255
 None
 1.12A 2cmlD-1z6rA:
undetectable		 2cmlD-1z6rA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlp PETAL DEATH PROTEIN

(Dianthus
caryophyllus) 		PF13714
(PEP_mutase) 		4 ASP A 107
SER A  66
SER A 257
ASN A 231
 MG  A 401 (-2.7A)
None
GAQ  A 402 ( 3.8A)
GAQ  A 402 (-3.9A)
 1.12A 2cmlD-1zlpA:
undetectable		 2cmlD-1zlpA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ass S-PHASE
KINASE-ASSOCIATED
PROTEIN 2

(Homo sapiens) 		PF12937
(F-box-like) 		4 SER B2291
ASP B2319
SER B2264
ASN B2289
 None
 1.10A 2cmlD-2assB:
undetectable		 2cmlD-2assB:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b0r POSSIBLE ADENYL
CYCLASE-ASSOCIATED
PROTEIN

(Cryptosporidium
parvum) 		PF08603
(CAP_C) 		4 SER A 111
SER A 112
SER A  93
ASN A  92
 None
 1.14A 2cmlD-2b0rA:
undetectable		 2cmlD-2b0rA:
22.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2htv NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		6 SER A 367
SER A 370
SER A 372
ASN A 400
TRP A 403
LYS A 432
 None
 0.64A 2cmlD-2htvA:
62.9		 2cmlD-2htvA:
45.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m26 HCF C-TERMINAL CHAIN
1

(Mus musculus) 		no annotation 4 SER A  83
ASP A 122
SER A 123
SER A  79
 None
 0.97A 2cmlD-2m26A:
undetectable		 2cmlD-2m26A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nli LACTATE OXIDASE

(Aerococcus
viridans) 		PF01070
(FMN_dh) 		4 SER A 276
SER A 263
SER A 297
ASN A  54
 None
FMN  A1375 (-3.3A)
FMN  A1375 (-4.0A)
None
 1.09A 2cmlD-2nliA:
undetectable		 2cmlD-2nliA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nmp CYSTATHIONINE
GAMMA-LYASE

(Homo sapiens) 		PF01053
(Cys_Met_Meta_PP) 		4 SER A 226
SER A 206
ASN A 188
GLN A 196
 None
 1.15A 2cmlD-2nmpA:
undetectable		 2cmlD-2nmpA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odl ADHESIN

(Haemophilus
influenzae) 		PF05860
(Haemagg_act) 		4 ASP A 294
SER A 290
ASN A 318
GLN A 319
 None
 0.94A 2cmlD-2odlA:
undetectable		 2cmlD-2odlA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbi GUANINE
NUCLEOTIDE-BINDING
PROTEIN SUBUNIT BETA
5

(Mus musculus) 		PF00400
(WD40) 		4 SER B 258
ASP B 260
SER B 240
ASN B 243
 None
 1.13A 2cmlD-2pbiB:
9.3		 2cmlD-2pbiB:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7g UROCANATE HYDRATASE

(Pseudomonas
putida) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		5 SER A 237
ASP A 213
SER A 193
ASN A 195
GLN A 182
 None
 1.49A 2cmlD-2v7gA:
undetectable		 2cmlD-2v7gA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vc6 DIHYDRODIPICOLINATE
SYNTHASE

(Sinorhizobium
meliloti) 		PF00701
(DHDPS) 		4 SER A  80
SER A  78
ASN A  79
LYS A  52
 None
 1.16A 2cmlD-2vc6A:
undetectable		 2cmlD-2vc6A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7j 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE
-1-CARBOXYLATE
SYNTHASE

(Bacillus
subtilis) 		PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
PF16582
(TPP_enzyme_M_2) 		4 ASP A 252
SER A 255
ASN A 259
GLN A 418
 None
 1.09A 2cmlD-2x7jA:
undetectable		 2cmlD-2x7jA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yeq ALKALINE PHOSPHATASE
D

(Bacillus
subtilis) 		PF09423
(PhoD)
PF16655
(PhoD_N) 		4 ASP A 350
SER A 351
ASN A 291
TRP A 337
 None
None
EDO  A 540 ( 4.3A)
None
 1.13A 2cmlD-2yeqA:
undetectable		 2cmlD-2yeqA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjq CEL44C

(Paenibacillus
polymyxa) 		PF12891
(Glyco_hydro_44) 		4 SER A 455
ASP A 457
SER A 458
ASN A 432
 None
 0.81A 2cmlD-2yjqA:
undetectable		 2cmlD-2yjqA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ymu WD-40 REPEAT PROTEIN

(Nostoc
punctiforme) 		PF00400
(WD40) 		4 SER A 281
ASP A 283
SER A 263
ASN A 266
 None
 1.14A 2cmlD-2ymuA:
6.4		 2cmlD-2ymuA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		4 SER B 431
SER B 432
SER B 406
ASN B 429
 NAG  A 831 (-3.6A)
NAG  A 833 ( 3.9A)
NAG  A 831 (-3.0A)
NAG  A 831 (-1.8A)
 1.12A 2cmlD-2z7xB:
undetectable		 2cmlD-2z7xB:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		4 SER A 444
SER A 445
SER A 421
ASN A 442
 NAG  A 921 ( 4.4A)
None
NAG  A 921 (-2.5A)
NAG  A 921 (-1.8A)
 1.02A 2cmlD-2z7xA:
undetectable		 2cmlD-2z7xA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Mus musculus) 		PF11921
(DUF3439)
PF13306
(LRR_5)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 SER A 444
SER A 445
SER A 421
ASN A 442
 NAG  A 811 ( 4.3A)
None
NAG  A 811 (-3.4A)
NAG  A 811 (-1.8A)
 1.08A 2cmlD-2z81A:
undetectable		 2cmlD-2z81A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a79 TOLL-LIKE RECEPTOR
6, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Mus musculus) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		4 SER B 436
SER B 437
SER B 411
ASN B 434
 NDG  B 971 (-3.6A)
NAG  B 972 ( 4.2A)
NDG  B 971 (-2.7A)
NDG  B 971 (-2.1A)
 1.07A 2cmlD-3a79B:
undetectable		 2cmlD-3a79B:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bzw PUTATIVE LIPASE

(Bacteroides
thetaiotaomicron) 		PF13472
(Lipase_GDSL_2) 		4 ASP A 203
SER A 191
ASN A 242
GLN A 248
 None
 1.03A 2cmlD-3bzwA:
undetectable		 2cmlD-3bzwA:
20.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ckz NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 SER A 367
SER A 370
TRP A 403
LYS A 432
 None
 0.86A 2cmlD-3ckzA:
64.3		 2cmlD-3ckzA:
47.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ckz NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 SER A 367
SER A 372
TRP A 403
LYS A 432
 None
 0.71A 2cmlD-3ckzA:
64.3		 2cmlD-3ckzA:
47.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fze PROTEIN STE5

(Saccharomyces
cerevisiae) 		PF12194
(Ste5_C) 		4 SER A 670
ASP A 666
SER A 667
ASN A 673
 None
 1.16A 2cmlD-3fzeA:
undetectable		 2cmlD-3fzeA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gip N-ACYL-D-GLUTAMATE
DEACYLASE

(Bordetella
bronchiseptica) 		PF07969
(Amidohydro_3) 		4 ASP A 365
SER A 364
SER A 380
LYS A  82
 ACY  A 481 ( 2.5A)
None
None
None
 0.89A 2cmlD-3gipA:
undetectable		 2cmlD-3gipA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gm8 GLYCOSIDE HYDROLASE
FAMILY 2, CANDIDATE
BETA-GLYCOSIDASE

(Bacteroides
vulgatus) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		4 SER A 255
ASP A 257
SER A 258
ASN A 298
 None
 1.01A 2cmlD-3gm8A:
undetectable		 2cmlD-3gm8A:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j70 ENVELOPE
GLYCOPROTEIN GP120

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		4 SER D 405
ASN D 340
GLN D 344
TRP D 395
 None
 1.00A 2cmlD-3j70D:
undetectable		 2cmlD-3j70D:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll3 GLUCONATE KINASE

(Lactobacillus
acidophilus) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 SER A 241
ASP A 237
SER A 427
GLN A 425
 None
XUL  A7778 (-2.9A)
None
None
 1.06A 2cmlD-3ll3A:
undetectable		 2cmlD-3ll3A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdo PUTATIVE
PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Parabacteroides
distasonis) 		PF02769
(AIRS_C) 		4 SER A 190
SER A 189
ASN A 335
GLN A 292
 None
None
CL  A 394 (-3.9A)
None
 1.08A 2cmlD-3mdoA:
undetectable		 2cmlD-3mdoA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oja LEUCINE-RICH IMMUNE
MOLECULE 1

(Anopheles
gambiae) 		PF00560
(LRR_1) 		4 SER A  88
SER A  89
SER A  64
ASN A  86
 NAG  A1001 ( 4.4A)
None
NAG  A1001 (-3.1A)
NAG  A1001 (-1.8A)
 1.15A 2cmlD-3ojaA:
undetectable		 2cmlD-3ojaA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r3j GLUTAMATE
DEHYDROGENASE

(Plasmodium
falciparum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 SER A 479
ASP A 487
SER A 486
GLN A 474
 None
 1.00A 2cmlD-3r3jA:
undetectable		 2cmlD-3r3jA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqg METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT

(uncultured
archaeon) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		4 SER B 356
SER B 355
SER B 359
GLN B 321
 None
 1.11A 2cmlD-3sqgB:
undetectable		 2cmlD-3sqgB:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t1e HEMAGGLUTININ-NEURAM
INIDASE

(Avian
avulavirus 1) 		PF00423
(HN) 		4 SER A 517
SER A 518
SER A 519
ASN A 549
 None
 1.13A 2cmlD-3t1eA:
21.7		 2cmlD-3t1eA:
21.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ti8 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 SER A 367
SER A 370
ASN A 400
TRP A 403
 None
 0.70A 2cmlD-3ti8A:
64.8		 2cmlD-3ti8A:
45.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ti8 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 SER A 367
SER A 372
ASN A 400
TRP A 403
 None
 0.20A 2cmlD-3ti8A:
64.8		 2cmlD-3ti8A:
45.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tia NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 SER A 367
SER A 370
SER A 372
ASN A 400
TRP A 403
 None
 0.65A 2cmlD-3tiaA:
64.7		 2cmlD-3tiaA:
43.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3whs GAMMA-GLUTAMYLTRANSP
EPTIDASE SMALL CHAIN

(Bacillus
subtilis) 		PF01019
(G_glu_transpept) 		4 SER B 520
SER B 522
SER B 523
ASN B 519
 None
 1.09A 2cmlD-3whsB:
undetectable		 2cmlD-3whsB:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wpe TOLL-LIKE RECEPTOR 9

(Bos taurus) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		4 SER A 148
SER A 150
SER A 130
ASN A 128
 None
 0.96A 2cmlD-3wpeA:
undetectable		 2cmlD-3wpeA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wpe TOLL-LIKE RECEPTOR 9

(Bos taurus) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		4 SER A 731
SER A 708
SER A 707
ASN A 729
 None
 1.16A 2cmlD-3wpeA:
undetectable		 2cmlD-3wpeA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bjj TRANSCRIPTION FACTOR
TAU SUBUNIT SFC1

(Schizosaccharomyces
pombe) 		PF09734
(Tau95) 		4 SER A   7
ASP A   8
SER A  91
ASN A  89
 None
 0.97A 2cmlD-4bjjA:
undetectable		 2cmlD-4bjjA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bx9 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 33A

(Homo sapiens) 		PF00995
(Sec1) 		4 ASP A 372
ASN A 390
GLN A 413
LYS A 405
 None
 1.10A 2cmlD-4bx9A:
undetectable		 2cmlD-4bx9A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gji L-RHAMNOSE ISOMERASE

(Pseudomonas
stutzeri) 		no annotation 4 ASP A 124
SER A  99
GLN A 328
TRP A  57
 None
None
None
RNS  A1001 (-3.5A)
 0.92A 2cmlD-4gjiA:
undetectable		 2cmlD-4gjiA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gos V-SET
DOMAIN-CONTAINING
T-CELL ACTIVATION
INHIBITOR 1

(Homo sapiens) 		PF07686
(V-set) 		4 SER A  55
SER A 114
ASN A 112
GLN A 107
 NAG  A 202 ( 4.5A)
NAG  A 201 (-3.2A)
NAG  A 201 (-1.9A)
NAG  A 201 (-4.7A)
 1.05A 2cmlD-4gosA:
undetectable		 2cmlD-4gosA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gvr METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE

(Archaeoglobus
fulgidus) 		PF02289
(MCH) 		4 ASP A 227
SER A 228
SER A 181
GLN A 179
 None
 1.06A 2cmlD-4gvrA:
undetectable		 2cmlD-4gvrA:
21.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4h53 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 SER A 367
SER A 370
SER A 372
ASN A 400
TRP A 403
 SIA  A 510 (-2.5A)
SIA  A 510 (-2.6A)
SIA  A 510 (-2.8A)
SIA  A 510 (-3.4A)
SIA  A 510 (-3.5A)
 0.63A 2cmlD-4h53A:
64.7		 2cmlD-4h53A:
51.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hcr PF-547659 HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 SER H 104
ASP H 106
SER H 102
SER H 103
 None
 1.16A 2cmlD-4hcrH:
undetectable		 2cmlD-4hcrH:
19.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hzz NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 SER A 367
SER A 372
ASN A 400
TRP A 403
 None
 0.25A 2cmlD-4hzzA:
62.8		 2cmlD-4hzzA:
50.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4io1 RIBOSE-5-PHOSPHATE
ISOMERASE A

(Francisella
tularensis) 		PF06026
(Rib_5-P_isom_A) 		4 SER A  59
ASP A  61
SER A  62
SER A  58
 None
 1.09A 2cmlD-4io1A:
undetectable		 2cmlD-4io1A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iug BETA-GALACTOSIDASE A

(Aspergillus
oryzae) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 SER A 464
SER A 442
SER A 440
ASN A 466
 None
 1.10A 2cmlD-4iugA:
undetectable		 2cmlD-4iugA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4izx RICIN B-LIKE LECTIN

(Macrolepiota
procera) 		PF14200
(RicinB_lectin_2) 		4 SER A  60
SER A  62
SER A  57
TRP A  44
 None
 1.03A 2cmlD-4izxA:
undetectable		 2cmlD-4izxA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0m SERINE/THREONINE-PRO
TEIN KINASE
BRI1-LIKE 1

(Arabidopsis
thaliana) 		PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 SER A 159
SER A 134
SER A 133
ASN A 157
 NAG  A 811 (-3.5A)
NAG  A 811 (-3.2A)
NAG  A 811 (-3.4A)
NAG  A 811 (-1.8A)
 1.12A 2cmlD-4j0mA:
undetectable		 2cmlD-4j0mA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0m SERINE/THREONINE-PRO
TEIN KINASE
BRI1-LIKE 1

(Arabidopsis
thaliana) 		PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 SER A 183
SER A 159
ASN A 157
GLN A 110
 None
NAG  A 811 (-3.5A)
NAG  A 811 (-1.8A)
None
 1.11A 2cmlD-4j0mA:
undetectable		 2cmlD-4j0mA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kfz ANTI-LMO2 VH

(Homo sapiens) 		PF07686
(V-set) 		4 SER C  56
SER C  57
SER C  52
ASN C  54
 None
 1.14A 2cmlD-4kfzC:
undetectable		 2cmlD-4kfzC:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 SER B 320
SER B 322
SER B 323
ASN B 318
 None
 1.10A 2cmlD-4m69B:
undetectable		 2cmlD-4m69B:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 SER A 277
SER A 278
SER A 253
ASN A 275
 NAG  A 803 (-3.1A)
NAG  A 804 ( 4.1A)
NAG  A 803 (-2.3A)
NAG  A 803 (-1.7A)
 1.09A 2cmlD-4m7eA:
undetectable		 2cmlD-4m7eA:
19.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mju NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 SER A 367
SER A 370
SER A 372
ASN A 400
TRP A 403
 None
 0.21A 2cmlD-4mjuA:
62.7		 2cmlD-4mjuA:
48.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzu 13PL LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 SER H  55
SER H  56
SER H  52
ASN H  53
 None
 1.10A 2cmlD-4nzuH:
undetectable		 2cmlD-4nzuH:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3r ARGINASE

(Schistosoma
mansoni) 		PF00491
(Arginase) 		4 SER A 167
SER A 165
ASN A 160
LYS A  86
 XA2  A 407 (-2.7A)
XA2  A 407 ( 4.4A)
XA2  A 407 (-4.2A)
None
 1.10A 2cmlD-4q3rA:
undetectable		 2cmlD-4q3rA:
20.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qn3 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 SER A 286
SER A 289
SER A 291
ASN A 318
TRP A 321
 None
 0.24A 2cmlD-4qn3A:
72.2		 2cmlD-4qn3A:
61.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r4z PNGF-II

(Elizabethkingia
meningoseptica) 		PF09112
(N-glycanase_N)
PF09113
(N-glycanase_C) 		4 SER A 471
SER A 481
SER A 479
ASN A 473
 None
 1.05A 2cmlD-4r4zA:
undetectable		 2cmlD-4r4zA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6f LEUCINE RICH REPEAT
DLRR_I

(synthetic
construct) 		PF12354
(Internalin_N)
PF13855
(LRR_8) 		4 SER A 196
SER A 197
SER A 164
ASN A 194
 None
 1.14A 2cmlD-4r6fA:
undetectable		 2cmlD-4r6fA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rcj YTH
DOMAIN-CONTAINING
FAMILY PROTEIN 1

(Homo sapiens) 		PF04146
(YTH) 		4 SER A 398
ASP A 400
SER A 396
TRP A 411
 None
 1.14A 2cmlD-4rcjA:
undetectable		 2cmlD-4rcjA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uop LIPOTEICHOIC ACID
PRIMASE

(Listeria
monocytogenes) 		PF00884
(Sulfatase) 		4 SER A 393
ASP A 364
SER A 363
GLN A 405
 None
 1.11A 2cmlD-4uopA:
undetectable		 2cmlD-4uopA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uwa RYANODINE RECEPTOR 1

(Oryctolagus
cuniculus) 		PF00622
(SPRY)
PF01365
(RYDR_ITPR)
PF02026
(RyR)
PF02815
(MIR)
PF08709
(Ins145_P3_rec) 		4 SER A1171
ASP A1172
SER A1173
SER A1175
 None
 1.12A 2cmlD-4uwaA:
undetectable		 2cmlD-4uwaA:
7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo sapiens) 		PF07686
(V-set) 		4 SER E 170
ASP E 233
SER E 166
SER E 165
 None
 1.12A 2cmlD-4v1dE:
undetectable		 2cmlD-4v1dE:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xb6 ALPHA-D-RIBOSE
1-METHYLPHOSPHONATE
5-TRIPHOSPHATE
SYNTHASE SUBUNIT
PHNI

(Escherichia
coli) 		PF05861
(PhnI) 		4 SER C 190
ASP C 176
SER C 191
GLN C 295
 None
 1.07A 2cmlD-4xb6C:
undetectable		 2cmlD-4xb6C:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y4v CONSERVED
HYPOTHETICAL
SECRETED PROTEIN

(Helicobacter
pylori) 		PF03734
(YkuD) 		4 SER A 274
ASP A 294
SER A 273
ASN A  66
 None
 1.09A 2cmlD-4y4vA:
undetectable		 2cmlD-4y4vA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhc STEROL REGULATORY
ELEMENT-BINDING
PROTEIN
CLEAVAGE-ACTIVATING
PROTEIN

(Schizosaccharomyces
pombe) 		no annotation 4 SER A 838
SER A 850
SER A 851
GLN A1003
 None
 1.08A 2cmlD-4yhcA:
6.9		 2cmlD-4yhcA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2e T-CELL
DIFFERENTIATION
ANTIGEN CD6

(Homo sapiens) 		PF00530
(SRCR) 		4 SER A  55
SER A  51
SER A  52
TRP A 238
 None
 1.00A 2cmlD-5a2eA:
undetectable		 2cmlD-5a2eA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5diz PROTEINACEOUS RNASE
P 2

(Arabidopsis
thaliana) 		PF16953
(PRORP)
PF17177
(PPR_long) 		4 SER A 114
SER A 111
ASN A 108
GLN A  66
 None
 1.13A 2cmlD-5dizA:
undetectable		 2cmlD-5dizA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e0q ANTI-NUP98 NANOBODY
TP377
NUCLEAR PORE COMPLEX
PROTEIN NUP98-NUP96

(Vicugna pacos;
Xenopus
tropicalis) 		PF04096
(Nucleoporin2)
PF07686
(V-set) 		4 ASP B 775
SER B 776
SER A  57
ASN A  54
 None
 0.99A 2cmlD-5e0qB:
undetectable		 2cmlD-5e0qB:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ejy MYOSIN-I HEAVY CHAIN

(Dictyostelium
discoideum) 		PF00784
(MyTH4) 		4 SER A 276
SER A 263
SER A 267
ASN A 279
 None
 0.99A 2cmlD-5ejyA:
undetectable		 2cmlD-5ejyA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fp2 FERRIC ENTEROBACTIN
RECEPTOR PIRA

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 ASP A 615
SER A 582
SER A 584
GLN A  33
 None
 1.04A 2cmlD-5fp2A:
undetectable		 2cmlD-5fp2A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		4 SER B 495
SER B 497
SER B 473
ASN B 471
 None
 1.00A 2cmlD-5gqrB:
undetectable		 2cmlD-5gqrB:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		4 SER B 495
SER B 497
SER B 473
GLN B 425
 None
 1.04A 2cmlD-5gqrB:
undetectable		 2cmlD-5gqrB:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hct ENDOTHIAPEPSIN

(Cryphonectria
parasitica) 		PF00026
(Asp) 		4 SER A 113
SER A  83
SER A 115
GLN A  56
 None
61P  A 406 (-3.0A)
None
None
 0.99A 2cmlD-5hctA:
undetectable		 2cmlD-5hctA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdh TOLL-LIKE RECEPTOR 8

(Homo sapiens) 		PF13855
(LRR_8) 		4 SER A  71
ASP A  72
SER A  50
ASN A  93
 None
 1.16A 2cmlD-5hdhA:
undetectable		 2cmlD-5hdhA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k04 UNCHARACTERIZED
PROTEIN

(Candida
albicans) 		PF09797
(NatB_MDM20) 		4 SER A  81
ASP A  78
SER A  77
SER A  89
 None
 0.89A 2cmlD-5k04A:
undetectable		 2cmlD-5k04A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqm GLYCOSYL HYDROLASES
FAMILY 2, SUGAR
BINDING DOMAIN

(Bacteroides
thetaiotaomicron) 		PF17132
(Glyco_hydro_106) 		4 SER A 580
ASP A 758
SER A 759
SER A 696
 None
 1.13A 2cmlD-5mqmA:
undetectable		 2cmlD-5mqmA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oc1 ARYL-ALCOHOL OXIDASE

(Pleurotus
eryngii) 		no annotation 4 SER A 210
ASP A  38
SER A 209
ASN A  15
 None
 1.06A 2cmlD-5oc1A:
undetectable		 2cmlD-5oc1A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5p60 ENDOTHIAPEPSIN

(Cryphonectria
parasitica) 		PF00026
(Asp) 		4 SER A 113
SER A  83
SER A 115
GLN A  56
 None
 1.05A 2cmlD-5p60A:
undetectable		 2cmlD-5p60A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpv WLARA,
TDP-FUCOSE-3,4-KETOI
SOMERASE

(Campylobacter
jejuni) 		PF05523
(FdtA) 		4 ASP A 115
SER A  54
ASN A  51
LYS A  32
 None
 1.08A 2cmlD-5tpvA:
undetectable		 2cmlD-5tpvA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v13 AAEL008620-PA
ODORANT-BINDING
PROTEIN

(Aedes aegypti) 		no annotation 4 SER B  40
GLN B  62
TRP B  50
LYS B  47
 None
 1.08A 2cmlD-5v13B:
undetectable		 2cmlD-5v13B:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1

(Homo sapiens) 		PF00400
(WD40)
PF00931
(NB-ARC) 		4 SER A 891
ASP A 893
SER A 895
SER A 896
 None
 0.94A 2cmlD-5wveA:
4.5		 2cmlD-5wveA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x49 PROBABLE XAA-PRO
AMINOPEPTIDASE 3

(Homo sapiens) 		PF00557
(Peptidase_M24)
PF05195
(AMP_N) 		4 SER A 101
ASP A 131
SER A 132
GLN A 128
 None
 1.09A 2cmlD-5x49A:
undetectable		 2cmlD-5x49A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnl OXYGEN-EVOLVING
ENHANCER PROTEIN 1,
CHLOROPLASTIC
OXYGEN-EVOLVING
ENHANCER PROTEIN 2,
CHLOROPLASTIC

(Pisum sativum) 		PF01716
(MSP)
PF01789
(PsbP) 		4 SER O 165
ASP P 137
SER O 155
SER O 154
 None
 0.91A 2cmlD-5xnlO:
undetectable		 2cmlD-5xnlO:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnu PUTATIVE INTEGRAL
MEMBRANE PROTEIN

(Escherichia
coli) 		no annotation 4 SER A 274
ASP A 507
SER A 506
ASN A 254
 None
 1.10A 2cmlD-5xnuA:
undetectable		 2cmlD-5xnuA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zln TOLL-LIKE RECEPTOR 9

(Mus musculus) 		no annotation 4 SER A 149
SER A 151
SER A 131
ASN A 129
 None
 1.00A 2cmlD-5zlnA:
undetectable		 2cmlD-5zlnA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zln TOLL-LIKE RECEPTOR 9

(Mus musculus) 		no annotation 5 SER A 503
ASP A 528
SER A 505
SER A 481
GLN A 399
 None
 1.44A 2cmlD-5zlnA:
undetectable		 2cmlD-5zlnA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b20 GUANINE
NUCLEOTIDE-BINDING
PROTEIN
G(I)/G(S)/G(T)
SUBUNIT BETA-1

(Bos taurus) 		no annotation 4 SER A 245
ASP A 247
SER A 227
ASN A 230
 None
 1.12A 2cmlD-6b20A:
8.9		 2cmlD-6b20A:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byw GOXA

(Pseudoalteromonas
luteoviolacea) 		no annotation 4 SER B 308
SER B 310
SER B 311
ASN B 321
 None
 0.91A 2cmlD-6bywB:
undetectable		 2cmlD-6bywB:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fi2 VEXL

(Achromobacter
denitrificans) 		no annotation 4 SER A 313
SER A 259
SER A 257
GLN A 231
 None
None
None
DJB  A 503 ( 3.3A)
 1.15A 2cmlD-6fi2A:
undetectable		 2cmlD-6fi2A:
12.24