SIMILAR PATTERNS OF AMINO ACIDS FOR 2CML_C_ZMRC3478_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0j TRYPSIN

(Salmo salar) 		PF00089
(Trypsin) 		4 SER A 145
SER A 147
SER A 148
ASN A 150
 None
 1.10A 2cmlC-1a0jA:
undetectable		 2cmlC-1a0jA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amu GRAMICIDIN
SYNTHETASE 1

(Brevibacillus
brevis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 SER A 231
ASP A 120
SER A 233
ASN A 515
 None
 1.10A 2cmlC-1amuA:
undetectable		 2cmlC-1amuA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cvm PHYTASE

(Bacillus
amyloliquefaciens) 		PF02333
(Phytase) 		4 SER A 283
ASP A 298
SER A 278
ASN A 281
 None
 1.01A 2cmlC-1cvmA:
13.7		 2cmlC-1cvmA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fw3 OUTER MEMBRANE
PHOSPHOLIPASE A

(Escherichia
coli) 		PF02253
(PLA1) 		4 SER A 248
ASP A 251
ASN A 113
GLN A  94
 None
None
S1H  A 144 ( 4.2A)
None
 1.11A 2cmlC-1fw3A:
undetectable		 2cmlC-1fw3A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jl5 OUTER PROTEIN YOPM

(Yersinia pestis) 		PF12468
(TTSSLRR) 		4 SER A1305
SER A1306
SER A1285
ASN A1303
 None
 1.08A 2cmlC-1jl5A:
undetectable		 2cmlC-1jl5A:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kb0 QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE

(Comamonas
testosteroni) 		PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3) 		4 SER A 453
ASP A 384
ASN A 413
GLN A 412
 None
 1.08A 2cmlC-1kb0A:
6.7		 2cmlC-1kb0A:
18.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nmb N9 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 SER N 367
SER N 370
SER N 372
TRP N 403
LYS N 432
 None
 0.66A 2cmlC-1nmbN:
70.7		 2cmlC-1nmbN:
68.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r47 ALPHA-GALACTOSIDASE
A

(Homo sapiens) 		PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C) 		4 SER A 235
ASP A 233
SER A 238
GLN A 280
 None
 1.11A 2cmlC-1r47A:
undetectable		 2cmlC-1r47A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tj5 SUCROSE-PHOSPHATASE

(Synechocystis
sp. PCC 6803) 		PF05116
(S6PP) 		4 SER A 150
ASP A 153
SER A 149
SER A 187
 SUC  A 245 ( 4.6A)
SUC  A 245 ( 4.0A)
SUC  A 245 (-3.6A)
MG  A 247 (-2.6A)
 1.06A 2cmlC-1tj5A:
undetectable		 2cmlC-1tj5A:
20.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1v0z NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		7 SER A 374
ASP A 376
SER A 377
SER A 379
ASN A 406
TRP A 409
LYS A 440
 None
 0.19A 2cmlC-1v0zA:
76.3		 2cmlC-1v0zA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1v0z NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		7 SER A 374
ASP A 376
SER A 377
SER A 379
GLN A 407
TRP A 409
LYS A 440
 None
 0.68A 2cmlC-1v0zA:
76.3		 2cmlC-1v0zA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xog NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		6 SER A 368
SER A 371
SER A 373
ASN A 400
TRP A 403
LYS A 434
 None
 0.85A 2cmlC-1xogA:
71.7		 2cmlC-1xogA:
69.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xwd FOLLICLE STIMULATING
HORMONE RECEPTOR

(Homo sapiens) 		PF01462
(LRRNT)
PF13306
(LRR_5) 		4 SER C 226
SER C 201
ASN C 199
GLN C 152
 None
 1.04A 2cmlC-1xwdC:
undetectable		 2cmlC-1xwdC:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ass S-PHASE
KINASE-ASSOCIATED
PROTEIN 2

(Homo sapiens) 		PF12937
(F-box-like) 		4 SER B2291
ASP B2319
SER B2264
ASN B2289
 None
 1.10A 2cmlC-2assB:
undetectable		 2cmlC-2assB:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ass S-PHASE
KINASE-ASSOCIATED
PROTEIN 2

(Homo sapiens) 		PF12937
(F-box-like) 		4 SER B2318
ASP B2316
SER B2341
SER B2343
 None
 1.06A 2cmlC-2assB:
undetectable		 2cmlC-2assB:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2axq SACCHAROPINE
DEHYDROGENASE

(Saccharomyces
cerevisiae) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		4 SER A  46
ASP A  19
SER A  48
GLN A  40
 None
 1.07A 2cmlC-2axqA:
undetectable		 2cmlC-2axqA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b0r POSSIBLE ADENYL
CYCLASE-ASSOCIATED
PROTEIN

(Cryptosporidium
parvum) 		PF08603
(CAP_C) 		4 SER A 111
SER A 112
SER A  93
ASN A  92
 None
 1.11A 2cmlC-2b0rA:
undetectable		 2cmlC-2b0rA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk3 PUTATIVE CYTOPLASMIC
PROTEIN

(Salmonella
enterica) 		PF07090
(GATase1_like) 		4 SER A 126
ASP A  82
SER A  81
ASN A 187
 None
GOL  A1001 (-3.4A)
None
None
 1.02A 2cmlC-2gk3A:
undetectable		 2cmlC-2gk3A:
20.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2htv NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		6 SER A 367
SER A 370
SER A 372
ASN A 400
TRP A 403
LYS A 432
 None
 0.68A 2cmlC-2htvA:
62.9		 2cmlC-2htvA:
45.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jf4 PERIPLASMIC
TREHALASE

(Escherichia
coli) 		PF01204
(Trehalase) 		4 SER A 315
SER A 314
GLN A 446
TRP A 311
 None
None
VDM  A1548 (-4.2A)
None
 1.13A 2cmlC-2jf4A:
undetectable		 2cmlC-2jf4A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m26 HCF C-TERMINAL CHAIN
1

(Mus musculus) 		no annotation 4 SER A  83
ASP A 122
SER A 123
SER A  79
 None
 1.05A 2cmlC-2m26A:
undetectable		 2cmlC-2m26A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p9n ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 1B

(Bos taurus) 		PF00400
(WD40) 		4 SER C 215
ASP C 230
SER C 211
ASN C 213
 None
 1.12A 2cmlC-2p9nC:
5.2		 2cmlC-2p9nC:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rds FE(II)/ALPHA-KETOGL
UTARATE DEPENDENT
HYDROXYLASE
1-DEOXYPENTALENIC
ACID 11-BETA
HYDROXYLASE

(Streptomyces
avermitilis) 		PF05721
(PhyH) 		4 SER A 163
SER A 233
ASN A 231
GLN A 122
 None
 1.13A 2cmlC-2rdsA:
undetectable		 2cmlC-2rdsA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v15 DNA PROTECTION
DURING STARVATION
PROTEIN

(Streptococcus
suis) 		PF00210
(Ferritin) 		4 SER A  25
ASP A 141
SER A 136
GLN A  31
 None
 1.01A 2cmlC-2v15A:
undetectable		 2cmlC-2v15A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjq CEL44C

(Paenibacillus
polymyxa) 		PF12891
(Glyco_hydro_44) 		4 SER A 455
ASP A 457
SER A 458
ASN A 432
 None
 0.83A 2cmlC-2yjqA:
undetectable		 2cmlC-2yjqA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		4 SER B 431
SER B 432
SER B 406
ASN B 429
 NAG  A 831 (-3.6A)
NAG  A 833 ( 3.9A)
NAG  A 831 (-3.0A)
NAG  A 831 (-1.8A)
 1.03A 2cmlC-2z7xB:
undetectable		 2cmlC-2z7xB:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		4 SER A 444
SER A 445
SER A 421
ASN A 442
 NAG  A 921 ( 4.4A)
None
NAG  A 921 (-2.5A)
NAG  A 921 (-1.8A)
 0.94A 2cmlC-2z7xA:
undetectable		 2cmlC-2z7xA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Mus musculus) 		PF11921
(DUF3439)
PF13306
(LRR_5)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 SER A 444
SER A 445
SER A 421
ASN A 442
 NAG  A 811 ( 4.3A)
None
NAG  A 811 (-3.4A)
NAG  A 811 (-1.8A)
 1.01A 2cmlC-2z81A:
undetectable		 2cmlC-2z81A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a79 TOLL-LIKE RECEPTOR
6, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Mus musculus) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		4 SER B 436
SER B 437
SER B 411
ASN B 434
 NDG  B 971 (-3.6A)
NAG  B 972 ( 4.2A)
NDG  B 971 (-2.7A)
NDG  B 971 (-2.1A)
 0.98A 2cmlC-3a79B:
undetectable		 2cmlC-3a79B:
21.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ckz NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 SER A 367
SER A 370
TRP A 403
LYS A 432
 None
 1.00A 2cmlC-3ckzA:
64.2		 2cmlC-3ckzA:
47.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ckz NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 SER A 367
SER A 372
TRP A 403
LYS A 432
 None
 0.71A 2cmlC-3ckzA:
64.2		 2cmlC-3ckzA:
47.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehm SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		4 SER A 242
ASP A 239
SER A 241
ASN A 197
 None
 0.93A 2cmlC-3ehmA:
undetectable		 2cmlC-3ehmA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbr ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Sulfolobus
solfataricus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		4 ASP A 268
SER A 265
SER A 116
ASN A  89
 None
None
None
PRP  A 401 (-4.1A)
 0.89A 2cmlC-3gbrA:
undetectable		 2cmlC-3gbrA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gip N-ACYL-D-GLUTAMATE
DEACYLASE

(Bordetella
bronchiseptica) 		PF07969
(Amidohydro_3) 		4 ASP A 365
SER A 364
SER A 380
LYS A  82
 ACY  A 481 ( 2.5A)
None
None
None
 0.94A 2cmlC-3gipA:
undetectable		 2cmlC-3gipA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gm8 GLYCOSIDE HYDROLASE
FAMILY 2, CANDIDATE
BETA-GLYCOSIDASE

(Bacteroides
vulgatus) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		4 SER A 255
ASP A 257
SER A 258
ASN A 298
 None
 0.97A 2cmlC-3gm8A:
undetectable		 2cmlC-3gm8A:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h74 PYRIDOXAL KINASE

(Lactobacillus
plantarum) 		PF08543
(Phos_pyr_kin) 		4 SER A  17
ASP A   9
SER A  19
GLN A 257
 None
 0.94A 2cmlC-3h74A:
undetectable		 2cmlC-3h74A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvn HEMOLYSIN

(Streptococcus
suis) 		PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C) 		4 SER A 266
SER A 267
SER A 360
GLN A 371
 None
 1.03A 2cmlC-3hvnA:
undetectable		 2cmlC-3hvnA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nfi DNA-DIRECTED RNA
POLYMERASE I SUBUNIT
RPA49

(Saccharomyces
cerevisiae) 		PF06870
(RNA_pol_I_A49) 		4 SER A 240
ASN A 238
GLN A 237
LYS A 245
 None
 1.07A 2cmlC-3nfiA:
undetectable		 2cmlC-3nfiA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o53 PROTEIN LRIM1

(Anopheles
gambiae) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		4 SER A  88
SER A  89
SER A  64
ASN A  86
 NAG  A1001 (-3.4A)
NAG  A1002 ( 4.9A)
NAG  A1001 (-3.6A)
NAG  A1001 (-1.7A)
 1.13A 2cmlC-3o53A:
undetectable		 2cmlC-3o53A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oja LEUCINE-RICH IMMUNE
MOLECULE 1

(Anopheles
gambiae) 		PF00560
(LRR_1) 		4 SER A  88
SER A  89
SER A  64
ASN A  86
 NAG  A1001 ( 4.4A)
None
NAG  A1001 (-3.1A)
NAG  A1001 (-1.8A)
 1.07A 2cmlC-3ojaA:
undetectable		 2cmlC-3ojaA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rht (GATASE1)-LIKE
PROTEIN

(Planctopirus
limnophila) 		PF07090
(GATase1_like) 		4 SER A  87
ASP A  55
SER A  54
ASN A 152
 None
GOL  A 260 ( 2.7A)
CA  A 257 ( 4.0A)
None
 1.09A 2cmlC-3rhtA:
undetectable		 2cmlC-3rhtA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t1e HEMAGGLUTININ-NEURAM
INIDASE

(Avian
avulavirus 1) 		PF00423
(HN) 		4 SER A 517
SER A 518
SER A 519
ASN A 549
 None
 1.08A 2cmlC-3t1eA:
21.6		 2cmlC-3t1eA:
21.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ti8 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 SER A 367
SER A 372
ASN A 400
TRP A 403
 None
 0.21A 2cmlC-3ti8A:
64.7		 2cmlC-3ti8A:
45.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tia NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 SER A 367
SER A 370
SER A 372
ASN A 400
TRP A 403
 None
 0.77A 2cmlC-3tiaA:
64.7		 2cmlC-3tiaA:
43.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3whs GAMMA-GLUTAMYLTRANSP
EPTIDASE SMALL CHAIN

(Bacillus
subtilis) 		PF01019
(G_glu_transpept) 		4 SER B 520
SER B 522
SER B 523
ASN B 519
 None
 1.05A 2cmlC-3whsB:
undetectable		 2cmlC-3whsB:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wpe TOLL-LIKE RECEPTOR 9

(Bos taurus) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		4 SER A 148
SER A 150
SER A 130
ASN A 128
 None
 0.89A 2cmlC-3wpeA:
undetectable		 2cmlC-3wpeA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw7 GH86A
BETA-PORPHYRANASE

(Bacteroides
plebeius) 		no annotation 4 ASP A 238
SER A 303
SER A 302
ASN A 460
 None
 1.08A 2cmlC-4aw7A:
undetectable		 2cmlC-4aw7A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bjj TRANSCRIPTION FACTOR
TAU SUBUNIT SFC1

(Schizosaccharomyces
pombe) 		PF09734
(Tau95) 		4 SER A   7
ASP A   8
SER A  91
ASN A  89
 None
 1.00A 2cmlC-4bjjA:
undetectable		 2cmlC-4bjjA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvc ALCOHOL
DEHYDROGENASE

(Pseudogluconobacter
saccharoketogenes) 		PF13360
(PQQ_2) 		4 SER A 358
SER A 395
GLN A 401
TRP A 383
 None
 1.06A 2cmlC-4cvcA:
5.0		 2cmlC-4cvcA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dgu PUTATIVE CELL
ADHESION PROTEIN

(Bacteroides
thetaiotaomicron) 		no annotation 4 SER A  37
ASP A  39
ASN A 140
GLN A 139
 None
 1.01A 2cmlC-4dguA:
undetectable		 2cmlC-4dguA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4t PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Burkholderia
ambifaria) 		PF02222
(ATP-grasp) 		4 SER A 286
SER A 201
ASN A 220
GLN A 219
 None
 1.10A 2cmlC-4e4tA:
undetectable		 2cmlC-4e4tA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f52 CULLIN-1

(Homo sapiens) 		PF00888
(Cullin) 		4 ASP A 427
SER A 479
ASN A 478
GLN A 477
 None
 1.13A 2cmlC-4f52A:
undetectable		 2cmlC-4f52A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7k LACCASE

(uncultured
bacterium) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 SER A  79
SER A 125
ASN A  73
GLN A  74
 None
 1.07A 2cmlC-4f7kA:
undetectable		 2cmlC-4f7kA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gnk 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3

(Homo sapiens) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		4 SER B 202
SER B 200
ASN B 165
GLN B 166
 None
 1.09A 2cmlC-4gnkB:
undetectable		 2cmlC-4gnkB:
14.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4h53 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 SER A 367
SER A 370
SER A 372
ASN A 400
TRP A 403
 SIA  A 510 (-2.5A)
SIA  A 510 (-2.6A)
SIA  A 510 (-2.8A)
SIA  A 510 (-3.4A)
SIA  A 510 (-3.5A)
 0.76A 2cmlC-4h53A:
64.7		 2cmlC-4h53A:
51.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hcr PF-547659 HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 SER H 104
ASP H 106
SER H 102
SER H 103
 None
 1.08A 2cmlC-4hcrH:
undetectable		 2cmlC-4hcrH:
19.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hzz NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 SER A 367
SER A 372
ASN A 400
TRP A 403
 None
 0.22A 2cmlC-4hzzA:
62.9		 2cmlC-4hzzA:
50.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4io1 RIBOSE-5-PHOSPHATE
ISOMERASE A

(Francisella
tularensis) 		PF06026
(Rib_5-P_isom_A) 		4 SER A  59
ASP A  61
SER A  62
SER A  58
 None
 1.13A 2cmlC-4io1A:
undetectable		 2cmlC-4io1A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iug BETA-GALACTOSIDASE A

(Aspergillus
oryzae) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 SER A 464
SER A 442
SER A 440
ASN A 466
 None
 1.03A 2cmlC-4iugA:
undetectable		 2cmlC-4iugA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4izo PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Burkholderia
thailandensis) 		PF02222
(ATP-grasp) 		4 SER A 286
SER A 201
ASN A 220
GLN A 219
 None
 1.08A 2cmlC-4izoA:
undetectable		 2cmlC-4izoA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4izx RICIN B-LIKE LECTIN

(Macrolepiota
procera) 		PF14200
(RicinB_lectin_2) 		4 SER A  60
SER A  62
SER A  57
GLN A  42
 None
None
None
LAT  A 201 ( 4.4A)
 0.82A 2cmlC-4izxA:
undetectable		 2cmlC-4izxA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4izx RICIN B-LIKE LECTIN

(Macrolepiota
procera) 		PF14200
(RicinB_lectin_2) 		4 SER A  60
SER A  62
SER A  57
TRP A  44
 None
 0.94A 2cmlC-4izxA:
undetectable		 2cmlC-4izxA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0m SERINE/THREONINE-PRO
TEIN KINASE
BRI1-LIKE 1

(Arabidopsis
thaliana) 		PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 ASP A 207
SER A 183
SER A 159
ASN A 157
GLN A 110
 None
None
NAG  A 811 (-3.5A)
NAG  A 811 (-1.8A)
None
 1.34A 2cmlC-4j0mA:
undetectable		 2cmlC-4j0mA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0m SERINE/THREONINE-PRO
TEIN KINASE
BRI1-LIKE 1

(Arabidopsis
thaliana) 		PF08263
(LRRNT_2)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 SER A 159
SER A 134
SER A 133
ASN A 157
 NAG  A 811 (-3.5A)
NAG  A 811 (-3.2A)
NAG  A 811 (-3.4A)
NAG  A 811 (-1.8A)
 1.11A 2cmlC-4j0mA:
undetectable		 2cmlC-4j0mA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kfz ANTI-LMO2 VH

(Homo sapiens) 		PF07686
(V-set) 		4 SER C  56
SER C  57
SER C  52
ASN C  54
 None
 1.06A 2cmlC-4kfzC:
undetectable		 2cmlC-4kfzC:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 SER B 320
SER B 322
SER B 323
ASN B 318
 None
 1.08A 2cmlC-4m69B:
undetectable		 2cmlC-4m69B:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 SER A 156
SER A 157
SER A 130
ASN A 154
 NAG  A 801 (-3.5A)
NAG  A 802 ( 3.8A)
NAG  A 801 (-3.3A)
NAG  A 801 (-1.8A)
 1.07A 2cmlC-4m7eA:
undetectable		 2cmlC-4m7eA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 SER A 277
SER A 278
SER A 253
ASN A 275
 NAG  A 803 (-3.1A)
NAG  A 804 ( 4.1A)
NAG  A 803 (-2.3A)
NAG  A 803 (-1.7A)
 1.01A 2cmlC-4m7eA:
undetectable		 2cmlC-4m7eA:
19.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mju NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 SER A 367
SER A 370
SER A 372
ASN A 400
TRP A 403
 None
 0.36A 2cmlC-4mjuA:
62.7		 2cmlC-4mjuA:
48.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzu 13PL LIGHT CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 SER H  55
SER H  56
SER H  52
ASN H  53
 None
 1.03A 2cmlC-4nzuH:
undetectable		 2cmlC-4nzuH:
20.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qn3 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 SER A 286
SER A 289
SER A 291
ASN A 318
TRP A 321
 None
 0.26A 2cmlC-4qn3A:
72.3		 2cmlC-4qn3A:
61.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r40 PROTEIN TOLB

(Yersinia pestis) 		PF04052
(TolB_N)
PF07676
(PD40) 		4 SER A 107
ASP A 109
SER A 111
GLN A 133
 None
 1.01A 2cmlC-4r40A:
12.8		 2cmlC-4r40A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r4z PNGF-II

(Elizabethkingia
meningoseptica) 		PF09112
(N-glycanase_N)
PF09113
(N-glycanase_C) 		4 SER A 471
SER A 481
SER A 479
ASN A 473
 None
 1.09A 2cmlC-4r4zA:
undetectable		 2cmlC-4r4zA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6f LEUCINE RICH REPEAT
DLRR_I

(synthetic
construct) 		PF12354
(Internalin_N)
PF13855
(LRR_8) 		4 SER A 196
SER A 197
SER A 164
ASN A 194
 None
 1.06A 2cmlC-4r6fA:
undetectable		 2cmlC-4r6fA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6f LEUCINE RICH REPEAT
DLRR_I

(synthetic
construct) 		PF12354
(Internalin_N)
PF13855
(LRR_8) 		4 SER A 276
SER A 277
SER A 244
ASN A 274
 None
 1.08A 2cmlC-4r6fA:
undetectable		 2cmlC-4r6fA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rws C-X-C CHEMOKINE
RECEPTOR TYPE
4/ENDOLYSIN CHIMERIC
PROTEIN

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme)
PF12109
(CXCR4_N) 		4 SER A 227
SER A 224
ASN A1068
GLN A1069
 None
 1.07A 2cmlC-4rwsA:
undetectable		 2cmlC-4rwsA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uop LIPOTEICHOIC ACID
PRIMASE

(Listeria
monocytogenes) 		PF00884
(Sulfatase) 		4 SER A 393
ASP A 364
SER A 363
GLN A 405
 None
 1.09A 2cmlC-4uopA:
undetectable		 2cmlC-4uopA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1d SINGLE CHAIN
ANTIBODY FRAGMENT
RU1, LIGHT CHAIN

(Homo sapiens) 		PF07686
(V-set) 		4 SER E 170
ASP E 233
SER E 166
SER E 165
 None
 1.12A 2cmlC-4v1dE:
undetectable		 2cmlC-4v1dE:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v20 CELLOBIOHYDROLASE

(Aspergillus
fumigatus) 		PF00840
(Glyco_hydro_7) 		4 SER A 222
ASP A 385
ASN A 264
GLN A 268
 None
 1.13A 2cmlC-4v20A:
undetectable		 2cmlC-4v20A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wgk NEUTRAL CERAMIDASE

(Homo sapiens) 		PF04734
(Ceramidase_alk)
PF17048
(Ceramidse_alk_C) 		4 ASP A 352
SER A 258
SER A 261
GLN A 587
 None
 1.07A 2cmlC-4wgkA:
undetectable		 2cmlC-4wgkA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y4v CONSERVED
HYPOTHETICAL
SECRETED PROTEIN

(Helicobacter
pylori) 		PF03734
(YkuD) 		4 SER A 274
ASP A 294
SER A 273
ASN A  66
 None
 0.96A 2cmlC-4y4vA:
undetectable		 2cmlC-4y4vA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zs7 LLAMA FAB FRAGMENT
68F2 HEAVY CHAIN

(Lama glama) 		PF07654
(C1-set)
PF07686
(V-set) 		4 SER H  28
ASN H  78
GLN H  79
TRP H  73
 None
 1.11A 2cmlC-4zs7H:
undetectable		 2cmlC-4zs7H:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2e T-CELL
DIFFERENTIATION
ANTIGEN CD6

(Homo sapiens) 		PF00530
(SRCR) 		4 SER A  55
SER A  51
SER A  52
TRP A 238
 None
 1.02A 2cmlC-5a2eA:
undetectable		 2cmlC-5a2eA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bzd 5G8 HIV ANTIBODY
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 SER B  28
ASN B  76
GLN B  77
TRP B  34
 None
 0.97A 2cmlC-5bzdB:
undetectable		 2cmlC-5bzdB:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e0q ANTI-NUP98 NANOBODY
TP377
NUCLEAR PORE COMPLEX
PROTEIN NUP98-NUP96

(Vicugna pacos;
Xenopus
tropicalis) 		PF04096
(Nucleoporin2)
PF07686
(V-set) 		4 ASP B 775
SER B 776
SER A  57
ASN A  54
 None
 1.12A 2cmlC-5e0qB:
undetectable		 2cmlC-5e0qB:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ejy MYOSIN-I HEAVY CHAIN

(Dictyostelium
discoideum) 		PF00784
(MyTH4) 		4 SER A 276
SER A 263
SER A 267
ASN A 279
 None
 0.98A 2cmlC-5ejyA:
undetectable		 2cmlC-5ejyA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fpr DNA LIGASE

(Staphylococcus
aureus) 		PF01653
(DNA_ligase_aden) 		4 SER A 233
ASP A 237
SER A 231
ASN A 285
 None
 1.10A 2cmlC-5fprA:
undetectable		 2cmlC-5fprA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		4 SER B 495
SER B 497
SER B 473
GLN B 425
 None
 1.05A 2cmlC-5gqrB:
undetectable		 2cmlC-5gqrB:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grs STEROL REGULATORY
ELEMENT-BINDING
PROTEIN
CLEAVAGE-ACTIVATING
PROTEIN

(Schizosaccharomyces
pombe) 		no annotation 4 SER A 838
SER A 850
SER A 851
GLN I1003
 None
 1.08A 2cmlC-5grsA:
6.6		 2cmlC-5grsA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ivx T-CELL RECEPTOR BETA
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ASP F  52
SER F  53
SER F  48
GLN F  24
 None
 1.10A 2cmlC-5ivxF:
undetectable		 2cmlC-5ivxF:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j2s KILLER CELL
LECTIN-LIKE RECEPTOR
SUBFAMILY B MEMBER
1B ALLELE A

(Rattus
norvegicus) 		no annotation 4 SER A 151
SER A 193
SER A 191
ASN A 206
 None
 1.11A 2cmlC-5j2sA:
undetectable		 2cmlC-5j2sA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k04 UNCHARACTERIZED
PROTEIN

(Candida
albicans) 		PF09797
(NatB_MDM20) 		4 SER A  81
ASP A  78
SER A  77
SER A  89
 None
 0.95A 2cmlC-5k04A:
undetectable		 2cmlC-5k04A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oc1 ARYL-ALCOHOL OXIDASE

(Pleurotus
eryngii) 		no annotation 4 SER A 210
ASP A  38
SER A 209
ASN A  15
 None
 1.10A 2cmlC-5oc1A:
undetectable		 2cmlC-5oc1A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tpv WLARA,
TDP-FUCOSE-3,4-KETOI
SOMERASE

(Campylobacter
jejuni) 		PF05523
(FdtA) 		4 ASP A 115
SER A  54
ASN A  51
LYS A  32
 None
 1.11A 2cmlC-5tpvA:
undetectable		 2cmlC-5tpvA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wve APOPTOTIC
PROTEASE-ACTIVATING
FACTOR 1

(Homo sapiens) 		PF00400
(WD40)
PF00931
(NB-ARC) 		4 SER A 891
ASP A 893
SER A 895
SER A 896
 None
 0.92A 2cmlC-5wveA:
8.9		 2cmlC-5wveA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnl OXYGEN-EVOLVING
ENHANCER PROTEIN 1,
CHLOROPLASTIC
OXYGEN-EVOLVING
ENHANCER PROTEIN 2,
CHLOROPLASTIC

(Pisum sativum) 		PF01716
(MSP)
PF01789
(PsbP) 		4 SER O 165
ASP P 137
SER O 155
SER O 154
 None
 0.88A 2cmlC-5xnlO:
undetectable		 2cmlC-5xnlO:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnu PUTATIVE INTEGRAL
MEMBRANE PROTEIN

(Escherichia
coli) 		no annotation 5 SER A 274
ASP A 507
SER A 506
ASN A 254
GLN A 252
 None
 1.34A 2cmlC-5xnuA:
undetectable		 2cmlC-5xnuA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zln TOLL-LIKE RECEPTOR 9

(Mus musculus) 		no annotation 4 SER A 149
SER A 151
SER A 131
ASN A 129
 None
 0.93A 2cmlC-5zlnA:
undetectable		 2cmlC-5zlnA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byw GOXA

(Pseudoalteromonas
luteoviolacea) 		no annotation 4 SER B 308
SER B 310
SER B 311
ASN B 321
 None
 0.94A 2cmlC-6bywB:
undetectable		 2cmlC-6bywB:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6y JC57-14 HEAVY CHAIN

(Macaca mulatta) 		no annotation 4 ASN A  76
GLN A  77
TRP A  34
LYS A  94
 None
 1.05A 2cmlC-6c6yA:
undetectable		 2cmlC-6c6yA:
11.31