SIMILAR PATTERNS OF AMINO ACIDS FOR 2CIZ_A_ACTA1321

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e0t PYRUVATE KINASE

(Escherichia
coli) 		PF00224
(PK)
PF02887
(PK_C) 		4 LEU A 397
PHE A 429
VAL A 449
ALA A 437
 None
 0.90A 2cizA-1e0tA:
0.0		 2cizA-1e0tA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hdg HOLO-D-GLYCERALDEHYD
E-3-PHOSPHATE
DEHYDROGENASE

(Thermotoga
maritima) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 LEU O 329
ASN O  22
VAL O   3
ALA O   1
 None
 1.21A 2cizA-1hdgO:
0.0		 2cizA-1hdgO:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iba GLUCOSE PERMEASE

(Escherichia
coli) 		PF00367
(PTS_EIIB) 		4 LEU A  39
PHE A  23
VAL A  62
ALA A  59
 None
 1.13A 2cizA-1ibaA:
undetectable		 2cizA-1ibaA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3b ATP-DEPENDENT
PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Thermus
thermophilus) 		PF01293
(PEPCK_ATP) 		4 LEU A 410
PHE A 231
VAL A 421
ALA A 364
 None
 1.22A 2cizA-1j3bA:
0.0		 2cizA-1j3bA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ka0 HALOTOLERANCE
PROTEIN HAL2

(Saccharomyces
cerevisiae) 		PF00459
(Inositol_P) 		4 LEU A  20
PHE A 150
VAL A 158
ALA A  52
 None
 1.12A 2cizA-1ka0A:
0.0		 2cizA-1ka0A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mrd IGG2B-KAPPA JEL103
FAB (HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 LEU H   4
ASN H  94
PHE H  99
ALA H  24
 None
 1.17A 2cizA-1mrdH:
undetectable		 2cizA-1mrdH:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sng COG4826: SERINE
PROTEASE INHIBITOR

(Thermobifida
fusca) 		PF00079
(Serpin) 		4 LEU A 305
PHE A 259
VAL A 221
ALA A 166
 None
 1.22A 2cizA-1sngA:
0.0		 2cizA-1sngA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ta3 XYLANASE INHIBITOR
PROTEIN I

(Triticum
aestivum) 		PF00704
(Glyco_hydro_18) 		4 LEU A 176
PHE A 217
VAL A 162
ALA A 160
 None
 1.07A 2cizA-1ta3A:
undetectable		 2cizA-1ta3A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1un2 THIOL-DISULFIDE
INTERCHANGE PROTEIN

(Escherichia
coli) 		PF01323
(DSBA) 		4 LEU A 172
PHE A  13
VAL A  32
ALA A  26
 None
 1.16A 2cizA-1un2A:
undetectable		 2cizA-1un2A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wc8 TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT3

(Mus musculus) 		PF04051
(TRAPP) 		4 LEU A 135
PHE A 103
VAL A 146
ALA A 148
 None
 1.13A 2cizA-1wc8A:
undetectable		 2cizA-1wc8A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wko TERMINAL FLOWER 1
PROTEIN

(Arabidopsis
thaliana) 		PF01161
(PBP) 		4 LEU A  12
ASN A  42
VAL A 124
ALA A 163
 None
 0.96A 2cizA-1wkoA:
undetectable		 2cizA-1wkoA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x5o RNA BINDING MOTIF,
SINGLE-STRANDED
INTERACTING PROTEIN
1

(Homo sapiens) 		PF00076
(RRM_1) 		4 LEU A  42
PHE A  86
VAL A  52
ALA A  71
 None
 0.69A 2cizA-1x5oA:
undetectable		 2cizA-1x5oA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yq2 BETA-GALACTOSIDASE

(Arthrobacter
sp. C2-2) 		PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 LEU A  26
ASN A 430
VAL A 297
ALA A 225
 None
 1.17A 2cizA-1yq2A:
undetectable		 2cizA-1yq2A:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yvp 60-KDA SS-A/RO
RIBONUCLEOPROTEIN

(Xenopus laevis) 		PF05731
(TROVE) 		4 LEU A 195
ASN A 192
VAL A 225
ALA A 161
 None
 1.19A 2cizA-1yvpA:
0.0		 2cizA-1yvpA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zba COAT PROTEIN VP2

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		4 LEU 2  81
PHE 2  62
VAL 2 107
ALA 2 201
 None
 1.19A 2cizA-1zba2:
undetectable		 2cizA-1zba2:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zr5 H2AFY PROTEIN

(Homo sapiens) 		PF01661
(Macro) 		4 LEU A 205
PHE A 181
VAL A 210
ALA A 308
 None
 1.01A 2cizA-1zr5A:
0.0		 2cizA-1zr5A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ci6 NG,
NG-DIMETHYLARGININE
DIMETHYLAMINOHYDROLA
SE 1

(Bos taurus) 		PF02274
(Amidinotransf) 		4 LEU A 264
ASN A 261
VAL A  37
ALA A  42
 None
 1.19A 2cizA-2ci6A:
0.0		 2cizA-2ci6A:
21.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ciy CHLOROPEROXIDASE

(Leptoxyphium
fumago) 		PF01328
(Peroxidase_2) 		5 LEU A  70
ASN A  74
PHE A 103
VAL A 182
ALA A 267
 DMS  A3036 (-3.9A)
DMS  A3036 (-3.9A)
DMS  A3036 (-3.8A)
MAN  A 741 ( 4.3A)
EDO  A 802 (-4.1A)
 0.31A 2cizA-2ciyA:
53.5		 2cizA-2ciyA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2co6 PUTATIVE FIMBRIAE
ASSEMBLY CHAPERONE

(Salmonella
enterica) 		PF00345
(PapD_N)
PF02753
(PapD_C) 		4 LEU B 146
ASN B 159
VAL B 205
ALA B 143
 None
 1.21A 2cizA-2co6B:
undetectable		 2cizA-2co6B:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fw2 TESTIS-SPECIFIC
CHROMODOMAIN PROTEIN
Y 2

(Homo sapiens) 		PF00378
(ECH_1) 		4 ASN A 128
PHE A 191
VAL A 182
ALA A 173
 None
 1.21A 2cizA-2fw2A:
undetectable		 2cizA-2fw2A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i80 D-ALANINE-D-ALANINE
LIGASE

(Staphylococcus
aureus) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		4 LEU A 278
ASN A 275
VAL A 223
ALA A 233
 None
 1.02A 2cizA-2i80A:
undetectable		 2cizA-2i80A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jg5 FRUCTOSE 1-PHOSPHATE
KINASE

(Staphylococcus
aureus) 		PF00294
(PfkB) 		4 LEU A 166
PHE A   7
VAL A 160
ALA A 162
 None
 1.01A 2cizA-2jg5A:
undetectable		 2cizA-2jg5A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l9f CALE8

(Micromonospora
echinospora) 		no annotation 4 LEU A  85
PHE A  73
VAL A  67
ALA A  59
 None
 1.15A 2cizA-2l9fA:
undetectable		 2cizA-2l9fA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mhc TNPX

(Clostridium
perfringens) 		PF00239
(Resolvase) 		4 LEU A  79
PHE A  64
VAL A  71
ALA A   9
 None
 1.01A 2cizA-2mhcA:
undetectable		 2cizA-2mhcA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oaj PROTEIN SNI1

(Saccharomyces
cerevisiae) 		PF08596
(Lgl_C) 		4 LEU A 543
PHE A 575
VAL A 613
ALA A 630
 None
 1.19A 2cizA-2oajA:
undetectable		 2cizA-2oajA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r44 UNCHARACTERIZED
PROTEIN

(Cytophaga
hutchinsonii) 		PF07726
(AAA_3) 		4 LEU A 128
PHE A 175
VAL A 117
ALA A 114
 None
 1.12A 2cizA-2r44A:
undetectable		 2cizA-2r44A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rb9 HYPE PROTEIN

(Escherichia
coli) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 LEU A 176
ASN A 271
VAL A 255
ALA A 266
 None
 1.00A 2cizA-2rb9A:
undetectable		 2cizA-2rb9A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rpb HYPOTHETICAL
MEMBRANE PROTEIN

(Pyrococcus
horikoshii) 		PF01145
(Band_7) 		4 LEU A 150
PHE A 111
VAL A  94
ALA A 119
 None
 1.11A 2cizA-2rpbA:
undetectable		 2cizA-2rpbA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpw HYPOTHETICAL
MEMBRANE SPANNING
PROTEIN

(Thermus
thermophilus) 		PF14589
(NrfD_2) 		4 LEU C 184
PHE C 221
VAL C 158
ALA C 234
 None
 1.03A 2cizA-2vpwC:
undetectable		 2cizA-2vpwC:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vwq GLUCOSE
DEHYDROGENASE

(Haloferax
mediterranei) 		PF08240
(ADH_N)
PF16912
(Glu_dehyd_C) 		4 LEU A 135
PHE A 128
VAL A  69
ALA A  28
 None
 1.11A 2cizA-2vwqA:
undetectable		 2cizA-2vwqA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x05 EXO-BETA-D-GLUCOSAMI
NIDASE

(Amycolatopsis
orientalis) 		PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N) 		4 LEU A 171
PHE A 186
VAL A 162
ALA A 157
 None
 1.19A 2cizA-2x05A:
undetectable		 2cizA-2x05A:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xf8 D-ERYTHROSE-4-PHOSPH
ATE DEHYDROGENASE

(Escherichia
coli) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 LEU A 117
ASN A 146
PHE A 317
VAL A  15
 None
None
3CD  A 600 (-3.7A)
None
 1.20A 2cizA-2xf8A:
undetectable		 2cizA-2xf8A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3a PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B) 		4 LEU A 828
PHE A 976
VAL A 904
ALA A 983
 None
 1.16A 2cizA-2y3aA:
undetectable		 2cizA-2y3aA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ys6 PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE

(Geobacillus
kaustophilus) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 LEU A 250
PHE A 284
VAL A 199
ALA A 197
 None
 1.13A 2cizA-2ys6A:
undetectable		 2cizA-2ys6A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yy9 ZINC FINGER AND BTB
DOMAIN-CONTAINING
PROTEIN 48

(Mus musculus) 		PF00651
(BTB) 		4 LEU A  44
PHE A  73
VAL A  63
ALA A  28
 None
 1.11A 2cizA-2yy9A:
undetectable		 2cizA-2yy9A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8e GALACTO-N-BIOSE/LACT
O-N-BIOSE I
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Bifidobacterium
longum) 		PF01547
(SBP_bac_1) 		4 ASN A 338
PHE A 134
VAL A 142
ALA A 317
 None
 1.16A 2cizA-2z8eA:
undetectable		 2cizA-2z8eA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aoe GLUTAMATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 LEU A 383
PHE A 359
VAL A 106
ALA A 351
 None
 1.14A 2cizA-3aoeA:
undetectable		 2cizA-3aoeA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3axy PROTEIN HEADING DATE
3A

(Oryza sativa) 		PF01161
(PBP) 		4 LEU A  11
ASN A  41
VAL A 123
ALA A 161
 None
 0.95A 2cizA-3axyA:
undetectable		 2cizA-3axyA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b84 ZINC FINGER AND BTB
DOMAIN-CONTAINING
PROTEIN 48

(Homo sapiens) 		PF00651
(BTB) 		4 LEU A  44
PHE A  73
VAL A  63
ALA A  28
 None
 1.03A 2cizA-3b84A:
undetectable		 2cizA-3b84A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eq1 PORPHOBILINOGEN
DEAMINASE

(Homo sapiens) 		PF01379
(Porphobil_deam)
PF03900
(Porphobil_deamC) 		4 LEU A 137
PHE A 163
VAL A 123
ALA A 185
 None
 1.03A 2cizA-3eq1A:
undetectable		 2cizA-3eq1A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjj MALTOSE
O-ACETYLTRANSFERASE

(Bacillus
anthracis) 		PF12464
(Mac)
PF14602
(Hexapep_2) 		4 LEU A  50
PHE A  68
VAL A  78
ALA A  62
 None
 1.15A 2cizA-3hjjA:
undetectable		 2cizA-3hjjA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hwp PHLG

(Pseudomonas
protegens) 		no annotation 4 LEU A  19
ASN A  23
PHE A  36
ALA A 128
 None
 1.06A 2cizA-3hwpA:
undetectable		 2cizA-3hwpA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE

(Ehrlichia
chaffeensis) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 LEU A 357
ASN A 359
VAL A 384
ALA A 401
 None
 0.84A 2cizA-3lp8A:
undetectable		 2cizA-3lp8A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmp RNA-DIRECTED RNA
POLYMERASE BETA
CHAIN

(Escherichia
virus Qbeta) 		no annotation 4 LEU G 363
PHE G 375
VAL G 343
ALA G 367
 None
 1.11A 2cizA-3mmpG:
undetectable		 2cizA-3mmpG:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3na8 PUTATIVE
DIHYDRODIPICOLINATE
SYNTHETASE

(Pseudomonas
aeruginosa) 		PF00701
(DHDPS) 		4 LEU A  87
PHE A 114
VAL A  98
ALA A 120
 None
 1.20A 2cizA-3na8A:
undetectable		 2cizA-3na8A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oe7 ATP SYNTHASE SUBUNIT
GAMMA

(Saccharomyces
cerevisiae) 		PF00231
(ATP-synt) 		4 LEU G  91
ASN G 167
PHE G 175
ALA G  94
 None
 1.22A 2cizA-3oe7G:
undetectable		 2cizA-3oe7G:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qt4 CATHEPSIN-L-LIKE
MIDGUT CYSTEINE
PROTEINASE

(Tenebrio
molitor) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		4 LEU A 239
ASN A 279
VAL A  74
ALA A 235
 None
None
PO4  A 401 (-4.1A)
None
 1.20A 2cizA-3qt4A:
undetectable		 2cizA-3qt4A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s99 BASIC MEMBRANE
LIPOPROTEIN

(Brucella
abortus) 		PF02608
(Bmp) 		4 LEU A  83
PHE A  25
VAL A  55
ALA A 257
 None
 1.20A 2cizA-3s99A:
undetectable		 2cizA-3s99A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujp MN TRANSPORTER
SUBUNIT

(Synechocystis
sp. PCC 6803) 		PF01297
(ZnuA) 		4 LEU A  58
PHE A 118
VAL A 128
ALA A 101
 None
 1.16A 2cizA-3ujpA:
undetectable		 2cizA-3ujpA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3up8 PUTATIVE
2,5-DIKETO-D-GLUCONI
C ACID REDUCTASE B

(Sinorhizobium
meliloti) 		PF00248
(Aldo_ket_red) 		4 LEU A 213
ASN A 237
VAL A 191
ALA A 185
 None
 1.10A 2cizA-3up8A:
undetectable		 2cizA-3up8A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8d CHOLESTEROL
7-ALPHA-MONOOXYGENAS
E

(Homo sapiens) 		PF00067
(p450) 		4 LEU A 361
PHE A 100
VAL A  76
ALA A 388
 None
 1.15A 2cizA-3v8dA:
undetectable		 2cizA-3v8dA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpx LEUCINE
DEHYDROGENASE

(Sporosarcina
psychrophila) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 LEU A  40
ASN A  69
VAL A 360
ALA A 295
 None
 0.90A 2cizA-3vpxA:
undetectable		 2cizA-3vpxA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vr5 V-TYPE SODIUM ATPASE
CATALYTIC SUBUNIT A
V-TYPE SODIUM ATPASE
SUBUNIT B

(Enterococcus
hirae;
Enterococcus
hirae) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
PF16886
(ATP-synt_ab_Xtn)
PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		4 LEU A  91
ASN D 117
VAL A 270
ALA A 293
 None
 1.01A 2cizA-3vr5A:
undetectable		 2cizA-3vr5A:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vtz GLUCOSE
1-DEHYDROGENASE

(Thermoplasma
volcanium) 		PF13561
(adh_short_C2) 		4 LEU A  77
ASN A  79
VAL A 159
ALA A 112
 None
 1.05A 2cizA-3vtzA:
undetectable		 2cizA-3vtzA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vu2 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME,
CHLOROPLASTIC/AMYLOP
LASTIC

(Oryza sativa) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		4 LEU A 256
PHE A 338
VAL A 219
ALA A 260
 None
 1.19A 2cizA-3vu2A:
undetectable		 2cizA-3vu2A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zu0 NAD NUCLEOTIDASE

(Haemophilus
influenzae) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		4 LEU A 224
ASN A 233
VAL A 240
ALA A 207
 None
 1.13A 2cizA-3zu0A:
undetectable		 2cizA-3zu0A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akr F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA

(Dictyostelium
discoideum) 		PF01267
(F-actin_cap_A) 		4 LEU A  40
PHE A  48
VAL A  30
ALA A  11
 None
 1.14A 2cizA-4akrA:
undetectable		 2cizA-4akrA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd) 		4 LEU A 828
PHE A 976
VAL A 904
ALA A 983
 None
 1.20A 2cizA-4bfrA:
undetectable		 2cizA-4bfrA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzx BIFUNCTIONAL ENZYME
CYSN/CYSC

(Mycobacterium
tuberculosis) 		PF01583
(APS_kinase) 		4 LEU A 501
ASN A 500
VAL A 520
ALA A 522
 ADX  A1613 (-4.3A)
ADX  A1613 (-3.5A)
None
ADX  A1613 (-3.6A)
 0.95A 2cizA-4bzxA:
undetectable		 2cizA-4bzxA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE

(Escherichia
coli;
Escherichia
virus Qbeta) 		PF00009
(GTP_EFTU)
PF00889
(EF_TS)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2)
PF03431
(RNA_replicase_B) 		4 LEU A1057
PHE A1069
VAL A1037
ALA A1061
 None
 1.16A 2cizA-4fwtA:
undetectable		 2cizA-4fwtA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h8e UNDECAPRENYL
PYROPHOSPHATE
SYNTHASE

(Staphylococcus
aureus) 		PF01255
(Prenyltransf) 		4 LEU A 104
PHE A  99
VAL A 114
ALA A 134
 None
FPP  A 302 (-3.8A)
None
None
 1.20A 2cizA-4h8eA:
undetectable		 2cizA-4h8eA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j16 NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA

(Thermus
thermophilus) 		PF02233
(PNTB) 		4 LEU C 397
ASN C 362
VAL C 296
ALA C 329
 None
 1.08A 2cizA-4j16C:
undetectable		 2cizA-4j16C:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jbh ALCOHOL
DEHYDROGENASE (ZINC)

(Pyrobaculum
aerophilum) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A 205
PHE A 301
VAL A 181
ALA A 172
 None
 0.84A 2cizA-4jbhA:
undetectable		 2cizA-4jbhA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jin RIO-TYPE
SERINE/THREONINE-PRO
TEIN KINASE RIO1

(Archaeoglobus
fulgidus) 		PF01163
(RIO1) 		4 LEU A 192
ASN A 123
VAL A 132
ALA A 190
 None
 1.12A 2cizA-4jinA:
undetectable		 2cizA-4jinA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mb2 PHOSPHOPANTOTHENATE
SYNTHETASE

(Thermococcus
onnurineus) 		PF02006
(PPS_PS) 		4 LEU A 235
ASN A 231
VAL A 197
ALA A 189
 None
 1.11A 2cizA-4mb2A:
undetectable		 2cizA-4mb2A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9u NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA

(Thermus
thermophilus) 		PF02233
(PNTB) 		4 LEU B 397
ASN B 362
VAL B 296
ALA B 329
 None
 1.09A 2cizA-4o9uB:
undetectable		 2cizA-4o9uB:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4od7 THIOL:DISULFIDE
INTERCHANGE PROTEIN

(Proteus
mirabilis) 		PF01323
(DSBA) 		4 LEU A  81
PHE A 111
VAL A 130
ALA A 124
 None
 1.19A 2cizA-4od7A:
undetectable		 2cizA-4od7A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p52 HOMOSERINE KINASE

(Cytophaga
hutchinsonii) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 LEU A 269
PHE A 151
VAL A  13
ALA A 173
 None
 1.18A 2cizA-4p52A:
undetectable		 2cizA-4p52A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgy ESTERASE

(uncultured
bacterium FLS12) 		PF00756
(Esterase) 		4 LEU A 112
PHE A  46
VAL A  21
ALA A  74
 None
 1.20A 2cizA-4rgyA:
undetectable		 2cizA-4rgyA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x54 OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY

(Brucella ovis) 		PF13561
(adh_short_C2) 		4 LEU A 106
ASN A 108
VAL A 205
ALA A 147
 None
 1.22A 2cizA-4x54A:
undetectable		 2cizA-4x54A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9v PARTICLE-ASSOCIATED
LYASE

(Acinetobacter
virus AP22) 		no annotation 4 LEU A 427
ASN A 397
VAL A 422
ALA A 425
 None
 1.19A 2cizA-4y9vA:
undetectable		 2cizA-4y9vA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ykn PHOSPHATIDYLINOSITOL
3-KINASE REGULATORY
SUBUNIT
ALPHA,PHOSPHATIDYLIN
OSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT ALPHA
ISOFORM FUSION
PROTEIN

(Homo sapiens) 		PF00017
(SH2)
PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B)
PF16454
(PI3K_P85_iSH2) 		4 LEU A1831
PHE A1980
VAL A1906
ALA A1987
 None
 1.16A 2cizA-4yknA:
undetectable		 2cizA-4yknA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zqb NADP-DEPENDENT
DEHYDROGENASE

(Rhodobacter
sphaeroides) 		PF02826
(2-Hacid_dh_C) 		4 LEU A  58
PHE A  34
VAL A  45
ALA A  48
 None
 1.11A 2cizA-4zqbA:
undetectable		 2cizA-4zqbA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aca VP2

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		4 LEU 2  81
PHE 2  62
VAL 2 107
ALA 2 202
 None
 1.11A 2cizA-5aca2:
undetectable		 2cizA-5aca2:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5any E1

(Chikungunya
virus) 		PF01589
(Alpha_E1_glycop) 		4 LEU A  33
ASN A   9
VAL A 163
ALA A 131
 None
 1.07A 2cizA-5anyA:
undetectable		 2cizA-5anyA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b4c UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE

(Pseudomonas
aeruginosa) 		PF00149
(Metallophos) 		4 LEU A  36
PHE A  22
VAL A  66
ALA A  30
 None
 1.04A 2cizA-5b4cA:
undetectable		 2cizA-5b4cA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b57 HEMIN IMPORT
ATP-BINDING PROTEIN
HMUV

(Burkholderia
cenocepacia) 		PF00005
(ABC_tran) 		4 LEU C 195
PHE C 156
VAL C 209
ALA C 211
 None
 0.95A 2cizA-5b57C:
undetectable		 2cizA-5b57C:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cz1 INTEGRASE

(Mouse mammary
tumor virus) 		PF00665
(rve) 		4 LEU A 188
ASN A 192
PHE A  88
ALA A  91
 None
 1.22A 2cizA-5cz1A:
undetectable		 2cizA-5cz1A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9q NIH45-46 SINGLE
CHAIN FV

(Homo sapiens) 		PF07686
(V-set) 		4 LEU D 276
PHE D 260
VAL D 298
ALA D 219
 None
 1.20A 2cizA-5d9qD:
undetectable		 2cizA-5d9qD:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dwa TYPE-2 RESTRICTION
ENZYME AGEI

(Thalassobius
gelatinovorus) 		no annotation 4 LEU A 100
PHE A 269
VAL A 143
ALA A 167
 None
 1.21A 2cizA-5dwaA:
undetectable		 2cizA-5dwaA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqx DESMOGLEIN-3

(Homo sapiens) 		PF00028
(Cadherin) 		4 LEU A 386
PHE A 341
VAL A 417
ALA A 415
 None
 1.07A 2cizA-5eqxA:
undetectable		 2cizA-5eqxA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbu PHOSPHOENOLPYRUVATE
SYNTHASE

(Listeria
monocytogenes) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N) 		4 LEU A 463
PHE A 708
VAL A 715
ALA A 687
 None
 0.75A 2cizA-5fbuA:
undetectable		 2cizA-5fbuA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hos CELLULASE

(Xanthomonas
citri) 		PF00150
(Cellulase) 		4 ASN A 165
PHE A 133
VAL A  79
ALA A 130
 None
 1.18A 2cizA-5hosA:
undetectable		 2cizA-5hosA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxf ASP/GLU-SPECIFIC
DIPEPTIDYL-PEPTIDASE

(Flavobacterium
psychrophilum) 		PF10459
(Peptidase_S46) 		4 LEU A 452
ASN A 397
VAL A 301
ALA A 297
 None
 1.13A 2cizA-5jxfA:
undetectable		 2cizA-5jxfA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1s OXIDOREDUCTASE,
ZINC-BINDING
DEHYDROGENASE FAMILY

(Myxococcus
xanthus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A 207
PHE A 312
VAL A 184
ALA A 175
 None
 1.07A 2cizA-5k1sA:
undetectable		 2cizA-5k1sA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8k UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE

(Haemophilus
influenzae) 		PF00149
(Metallophos) 		4 LEU A  37
PHE A  23
VAL A  67
ALA A  31
 None
 1.21A 2cizA-5k8kA:
undetectable		 2cizA-5k8kA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlc 50S RIBOSOMAL
PROTEIN L23,
CHLOROPLASTIC
50S RIBOSOMAL
PROTEIN L29,
CHLOROPLASTIC

(Spinacia
oleracea;
Spinacia
oleracea) 		PF00276
(Ribosomal_L23)
PF00831
(Ribosomal_L29) 		4 LEU V 115
PHE V 155
VAL Z 146
ALA V 150
 None
 1.08A 2cizA-5mlcV:
undetectable		 2cizA-5mlcV:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqd ARSENITE OXIDASE
LARGE SUBUNIT AIOA
[3FE-4S] CLUSTER,
MO-MOLYBDOPTERIN
COFACTOR-BINDING
ACTIVE SITE

(Rhizobium sp.
NT-26) 		no annotation 4 LEU A 303
PHE A 314
VAL A 233
ALA A 391
 None
 1.17A 2cizA-5nqdA:
undetectable		 2cizA-5nqdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t87 CDII IMMUNITY
PROTEIN

(Cupriavidus
taiwanensis) 		no annotation 4 LEU A  89
PHE A  46
VAL A  67
ALA A 105
 None
 1.22A 2cizA-5t87A:
undetectable		 2cizA-5t87A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE

(Brucella suis) 		PF00106
(adh_short) 		4 LEU A 100
ASN A 102
VAL A 192
ALA A 135
 None
 1.16A 2cizA-5tgdA:
undetectable		 2cizA-5tgdA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uid AMINOTRANSFERASE
TLMJ

(Streptoalloteichus
hindustanus) 		PF01041
(DegT_DnrJ_EryC1) 		4 LEU A  64
PHE A 196
VAL A  55
ALA A 209
 None
 1.07A 2cizA-5uidA:
undetectable		 2cizA-5uidA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vu2 E1 ENVELOPE
GLYCOPROTEIN

(Chikungunya
virus) 		no annotation 4 LEU M  33
ASN M   9
VAL M 163
ALA M 131
 None
 0.96A 2cizA-5vu2M:
undetectable		 2cizA-5vu2M:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w16 GLUTAMATE RACEMASE

(Thermus
thermophilus) 		no annotation 4 LEU A 210
PHE A  33
VAL A  72
ALA A  70
 None
 1.20A 2cizA-5w16A:
undetectable		 2cizA-5w16A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdu BNAB NIH45-46 SCFV
LIGHT CHAIN

(Homo sapiens) 		no annotation 4 LEU E  76
PHE E  60
VAL E  98
ALA E  19
 None
 1.04A 2cizA-5wduE:
undetectable		 2cizA-5wduE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5weg UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE

(Saccharum
hybrid cultivar) 		no annotation 4 LEU A 304
PHE A 350
VAL A 202
ALA A 343
 None
None
None
SO4  A 506 (-4.0A)
 1.14A 2cizA-5wegA:
undetectable		 2cizA-5wegA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wly UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE

(Escherichia
coli) 		no annotation 4 LEU A  36
PHE A  22
VAL A  66
ALA A  30
 None
 1.07A 2cizA-5wlyA:
undetectable		 2cizA-5wlyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7n DIAMINOPIMELATE
DECARBOXYLASE

(Corynebacterium
glutamicum) 		no annotation 4 LEU A 145
PHE A 188
VAL A 161
ALA A 202
 None
 1.10A 2cizA-5x7nA:
undetectable		 2cizA-5x7nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfa NAD-REDUCING
HYDROGENASE

(Hydrogenophilus
thermoluteolus) 		PF10588
(NADH-G_4Fe-4S_3)
PF13459
(Fer4_15)
PF13510
(Fer2_4) 		4 LEU B  71
PHE B  13
VAL B  59
ALA B  61
 None
 1.18A 2cizA-5xfaB:
undetectable		 2cizA-5xfaB:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgj PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT ALPHA
ISOFORM

(Homo sapiens) 		no annotation 4 LEU A 831
PHE A 980
VAL A 906
ALA A 987
 None
 1.16A 2cizA-5xgjA:
undetectable		 2cizA-5xgjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fsw RIBOSOME MATURATION
PROTEIN SDO1-LIKE
PROTEIN

(Archaeoglobus
fulgidus) 		no annotation 4 LEU A  45
PHE A  51
VAL A  74
ALA A  78
 None
 1.20A 2cizA-6fswA:
undetectable		 2cizA-6fswA:
undetectable