SIMILAR PATTERNS OF AMINO ACIDS FOR 2CIZ_A_ACTA1320

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aj6 GYRASE

(Escherichia
coli) 		PF02518
(HATPase_c) 		4 ALA A 188
PHE A 216
ILE A 203
VAL A  61
 None
 0.90A 2cizA-1aj6A:
undetectable		 2cizA-1aj6A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1awe SOS1

(Homo sapiens) 		PF00169
(PH) 		4 PHE A 126
ILE A 101
VAL A  99
PHE A  95
 None
 0.97A 2cizA-1aweA:
undetectable		 2cizA-1aweA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d1d PROTEIN (CAPSID
PROTEIN)

(Rous sarcoma
virus) 		PF00607
(Gag_p24) 		4 ALA A 186
ILE A 172
VAL A 175
GLU A 176
 None
 0.68A 2cizA-1d1dA:
0.0		 2cizA-1d1dA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gve AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 3

(Rattus
norvegicus) 		PF00248
(Aldo_ket_red) 		4 ALA A 263
ILE A 241
VAL A 244
GLU A 245
 None
 0.93A 2cizA-1gveA:
undetectable		 2cizA-1gveA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ldn L-LACTATE
DEHYDROGENASE

(Geobacillus
stearothermophilus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 ALA A  33
PHE A  65
ILE A  48
VAL A  25
 None
 0.92A 2cizA-1ldnA:
0.0		 2cizA-1ldnA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ltl DNA REPLICATION
INITIATOR
(CDC21/CDC54)

(Methanothermobacter
thermautotrophicus) 		PF14551
(MCM_N)
PF17207
(MCM_OB) 		4 ALA A  68
ILE A  39
VAL A  41
PHE A  88
 None
 0.61A 2cizA-1ltlA:
undetectable		 2cizA-1ltlA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgw BEAN POD MOTTLE
VIRUS LARGE (L)
SUBUNIT

(Bean pod mottle
virus) 		PF02247
(Como_LCP) 		4 ALA 2 328
PHE 2 202
ILE 2 344
VAL 2 346
 None
 0.91A 2cizA-1pgw2:
undetectable		 2cizA-1pgw2:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhx PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)

(Streptomyces
venezuelae) 		PF07931
(CPT) 		4 PHE A  68
ILE A  64
VAL A  62
PHE A  56
 None
 0.91A 2cizA-1qhxA:
0.0		 2cizA-1qhxA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qzg PROTECTION OF
TELOMERES PROTEIN 1

(Schizosaccharomyces
pombe) 		PF02765
(POT1) 		4 ALA A 162
PHE A  46
ILE A  22
GLU A 158
 None
 0.74A 2cizA-1qzgA:
undetectable		 2cizA-1qzgA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb7 TRNA PSEUDOURIDINE
SYNTHASE D

(Escherichia
coli) 		PF01142
(TruD) 		4 ALA A 330
PHE A 322
VAL A  29
PHE A  27
 GOL  A1203 (-3.7A)
None
None
GOL  A1203 (-4.3A)
 0.81A 2cizA-1sb7A:
0.0		 2cizA-1sb7A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlj NADH-DEPENDENT
BUTANOL
DEHYDROGENASE

(Thermotoga
maritima) 		PF00465
(Fe-ADH) 		4 ALA A 107
ILE A 128
VAL A 164
PHE A 122
 None
 0.93A 2cizA-1vljA:
0.1		 2cizA-1vljA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z2z PROBABLE TRNA
PSEUDOURIDINE
SYNTHASE D

(Methanosarcina
mazei) 		PF01142
(TruD) 		4 ALA A 422
PHE A 414
VAL A  35
PHE A  33
 None
 0.71A 2cizA-1z2zA:
undetectable		 2cizA-1z2zA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bp1 AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 2

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		4 ALA A 296
ILE A 274
VAL A 277
GLU A 278
 None
 0.93A 2cizA-2bp1A:
0.0		 2cizA-2bp1A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c91 AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 2

(Mus musculus) 		PF00248
(Aldo_ket_red) 		4 ALA A 263
ILE A 241
VAL A 244
GLU A 245
 None
 0.96A 2cizA-2c91A:
undetectable		 2cizA-2c91A:
20.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ciy CHLOROPEROXIDASE

(Leptoxyphium
fumago) 		PF01328
(Peroxidase_2) 		6 ALA A  71
PHE A 103
ILE A 179
VAL A 182
GLU A 183
PHE A 186
 HEM  A 396 (-3.6A)
DMS  A3036 (-3.8A)
DMS  A3036 (-4.8A)
MAN  A 741 ( 4.3A)
CYN  A1802 ( 3.6A)
HEM  A 396 ( 4.0A)
 0.24A 2cizA-2ciyA:
53.5		 2cizA-2ciyA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e9y CARBAMATE KINASE

(Aeropyrum
pernix) 		PF00696
(AA_kinase) 		4 ALA A 257
ILE A 283
VAL A 286
GLU A 287
 None
 0.75A 2cizA-2e9yA:
undetectable		 2cizA-2e9yA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ei0 1,2-DIHYDROXYNAPHTHA
LENE DIOXYGENASE

(Pseudomonas sp.
C18) 		PF00903
(Glyoxalase) 		4 ALA A  27
ILE A  55
VAL A  57
PHE A  44
 None
 0.86A 2cizA-2ei0A:
undetectable		 2cizA-2ei0A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5t ARCHAEAL
TRANSCRIPTIONAL
REGULATOR TRMB

(Thermococcus
litoralis) 		PF11495
(Regulator_TrmB) 		4 PHE X 144
ILE X 165
VAL X 182
PHE X 180
 None
 0.97A 2cizA-2f5tX:
undetectable		 2cizA-2f5tX:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g2o MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Escherichia
coli) 		PF00698
(Acyl_transf_1) 		4 ALA A 144
ILE A 169
VAL A 167
PHE A 161
 None
 0.87A 2cizA-2g2oA:
undetectable		 2cizA-2g2oA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gah HETEROTETRAMERIC
SARCOSINE OXIDASE
ALPHA-SUBUNIT

(Stenotrophomonas
maltophilia) 		PF01571
(GCV_T)
PF07992
(Pyr_redox_2)
PF08669
(GCV_T_C)
PF13510
(Fer2_4) 		4 ALA A 643
PHE A 688
ILE A 637
VAL A 717
 None
 0.94A 2cizA-2gahA:
undetectable		 2cizA-2gahA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9u CYTOSINE/GUANINE
DEAMINASE RELATED
PROTEIN

(Clostridium
acetobutylicum) 		PF01979
(Amidohydro_1) 		4 ALA A 385
PHE A 377
ILE A  41
VAL A  36
 None
 0.95A 2cizA-2i9uA:
undetectable		 2cizA-2i9uA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE

(Homo sapiens) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 ALA A 382
VAL A 393
GLU A 394
PHE A 397
 None
None
NH4  A1461 (-3.7A)
None
 0.90A 2cizA-2iwzA:
undetectable		 2cizA-2iwzA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix2 DNA POLYMERASE
SLIDING CLAMP B

(Sulfolobus
solfataricus) 		PF00705
(PCNA_N) 		4 ALA A 235
PHE A  15
ILE A  52
VAL A  56
 None
 0.87A 2cizA-2ix2A:
undetectable		 2cizA-2ix2A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jak SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
56 KDA REGULATORY
SUBUNIT GAMMA
ISOFORM

(Homo sapiens) 		PF01603
(B56) 		4 ALA A 155
PHE A 193
ILE A 189
PHE A 144
 None
 0.96A 2cizA-2jakA:
undetectable		 2cizA-2jakA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lhi CALMODULIN,
SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT A1

(Saccharomyces
cerevisiae;
synthetic
construct) 		PF13499
(EF-hand_7) 		4 ALA A 464
ILE A 112
VAL A  35
PHE A  19
 None
 0.82A 2cizA-2lhiA:
undetectable		 2cizA-2lhiA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lpm TWO-COMPONENT
RESPONSE REGULATOR

(Sinorhizobium
meliloti) 		PF00072
(Response_reg) 		4 ALA A  72
PHE A  84
ILE A  58
VAL A  14
 None
 0.86A 2cizA-2lpmA:
undetectable		 2cizA-2lpmA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qip PROTEIN OF UNKNOWN
FUNCTION VPA0982

(Vibrio
parahaemolyticus) 		PF01936
(NYN) 		4 PHE A  63
ILE A  66
VAL A  70
PHE A  72
 None
 0.93A 2cizA-2qipA:
undetectable		 2cizA-2qipA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wfi PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
G

(Homo sapiens) 		PF00160
(Pro_isomerase) 		4 PHE A  65
ILE A  14
VAL A  24
PHE A  26
 None
 0.92A 2cizA-2wfiA:
undetectable		 2cizA-2wfiA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x25 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
A

(Homo sapiens) 		PF00160
(Pro_isomerase) 		4 PHE B  53
ILE B  10
VAL B  20
PHE B  22
 None
 0.84A 2cizA-2x25B:
undetectable		 2cizA-2x25B:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7x SENSOR PROTEIN

(Bacteroides
thetaiotaomicron) 		PF13407
(Peripla_BP_4) 		4 ALA A 233
ILE A 215
VAL A 218
PHE A 244
 None
 0.94A 2cizA-2x7xA:
undetectable		 2cizA-2x7xA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yp1 AROMATIC
PEROXYGENASE

(Agrocybe
aegerita) 		PF01328
(Peroxidase_2) 		4 ALA A  77
ILE A  60
VAL A  63
PHE A  69
 ACT  A1327 ( 3.5A)
None
HEM  A 350 (-4.2A)
HEM  A 350 (-3.7A)
 0.82A 2cizA-2yp1A:
19.9		 2cizA-2yp1A:
26.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yp1 AROMATIC
PEROXYGENASE

(Agrocybe
aegerita) 		PF01328
(Peroxidase_2) 		4 ALA A  77
PHE A 121
GLU A 196
PHE A 199
 ACT  A1327 ( 3.5A)
HEM  A 350 (-4.0A)
HEM  A 350 ( 3.5A)
HEM  A 350 ( 4.8A)
 0.75A 2cizA-2yp1A:
19.9		 2cizA-2yp1A:
26.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z4t BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE

(Photobacterium
sp. JT-ISH-224) 		PF11477
(PM0188) 		4 ALA A 445
PHE A 357
ILE A 382
VAL A 381
 None
 0.91A 2cizA-2z4tA:
undetectable		 2cizA-2z4tA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0f UNCHARACTERIZED
PROTEIN AF_1514

(Archaeoglobus
fulgidus) 		no annotation 4 ALA B  20
PHE B  79
ILE B  72
VAL B   9
 None
None
MLY  B  71 ( 4.0A)
MLY  B   8 ( 3.2A)
 0.89A 2cizA-3c0fB:
undetectable		 2cizA-3c0fB:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cq5 HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Corynebacterium
glutamicum) 		PF00155
(Aminotran_1_2) 		5 ALA A 249
PHE A 109
ILE A 193
VAL A 221
PHE A 240
 None
 1.40A 2cizA-3cq5A:
undetectable		 2cizA-3cq5A:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0l GUANINE DEAMINASE

(Homo sapiens) 		PF01979
(Amidohydro_1) 		4 ALA A 395
PHE A 387
ILE A  42
VAL A  36
 None
 0.93A 2cizA-3e0lA:
undetectable		 2cizA-3e0lA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efc OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR YAET

(Escherichia
coli) 		PF07244
(POTRA) 		4 ALA A  42
VAL A  88
GLU A  90
PHE A  72
 None
 0.98A 2cizA-3efcA:
undetectable		 2cizA-3efcA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdx PUTATIVE FILAMENT
PROTEIN / UNIVERSAL
STRESS PROTEIN F

(Klebsiella
pneumoniae) 		PF00582
(Usp) 		4 ALA A  73
ILE A  18
VAL A  21
GLU A  22
 FMT  A 402 ( 4.1A)
None
None
None
 0.77A 2cizA-3fdxA:
undetectable		 2cizA-3fdxA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fkr L-2-KETO-3-DEOXYARAB
ONATE DEHYDRATASE

(Azospirillum
brasilense) 		PF00701
(DHDPS) 		4 ALA A 172
ILE A 151
VAL A 153
PHE A 181
 None
 0.96A 2cizA-3fkrA:
undetectable		 2cizA-3fkrA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1g GAG POLYPROTEIN

(Rous sarcoma
virus) 		no annotation 4 ALA A 186
ILE A 172
VAL A 175
GLU A 176
 None
 0.63A 2cizA-3g1gA:
undetectable		 2cizA-3g1gA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjv MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Vibrio cholerae) 		PF00698
(Acyl_transf_1) 		4 ALA A 149
ILE A 174
VAL A 172
PHE A 166
 None
 0.96A 2cizA-3hjvA:
undetectable		 2cizA-3hjvA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i2v ADENYLYLTRANSFERASE
AND
SULFURTRANSFERASE
MOCS3

(Homo sapiens) 		PF00581
(Rhodanese) 		4 ALA A  58
ILE A  74
VAL A  72
PHE A  16
 None
 0.95A 2cizA-3i2vA:
undetectable		 2cizA-3i2vA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5t AMINOTRANSFERASE

(Rhodobacter
sphaeroides) 		PF00202
(Aminotran_3) 		4 ALA A 162
ILE A 146
VAL A 148
PHE A 182
 None
 0.87A 2cizA-3i5tA:
undetectable		 2cizA-3i5tA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lg6 PUTATIVE GLUTATHIONE
TRANSFERASE

(Coccidioides
immitis) 		PF13409
(GST_N_2)
PF14497
(GST_C_3) 		4 ALA A  91
ILE A  65
VAL A  62
PHE A   6
 None
 0.94A 2cizA-3lg6A:
undetectable		 2cizA-3lg6A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lop SUBSTRATE BINDING
PERIPLASMIC PROTEIN

(Ralstonia
solanacearum) 		PF13458
(Peripla_BP_6) 		4 ALA A 327
ILE A  36
VAL A  38
PHE A  63
 None
 0.96A 2cizA-3lopA:
undetectable		 2cizA-3lopA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m62 UBIQUITIN
CONJUGATION FACTOR
E4

(Saccharomyces
cerevisiae) 		PF04564
(U-box)
PF10408
(Ufd2P_core) 		4 ALA A 861
ILE A 820
VAL A 823
PHE A 830
 None
 0.84A 2cizA-3m62A:
undetectable		 2cizA-3m62A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mxg SHIGA-LIKE TOXIN 2
SUBUNIT B

(Escherichia
coli) 		PF02258
(SLT_beta) 		4 PHE A  62
ILE A  51
VAL A  49
PHE A  67
 None
 0.95A 2cizA-3mxgA:
undetectable		 2cizA-3mxgA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oi8 UNCHARACTERIZED
PROTEIN

(Neisseria
meningitidis) 		PF00571
(CBS) 		4 ALA A 156
PHE A 148
ILE A 174
VAL A  60
 None
 0.98A 2cizA-3oi8A:
undetectable		 2cizA-3oi8A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4d MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY
POSSIBLE
CHLOROMUCONATE
CYCLOISOMERASE

(Cytophaga
hutchinsonii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ALA A 308
PHE A 319
ILE A 334
VAL A 344
 None
 0.96A 2cizA-3q4dA:
undetectable		 2cizA-3q4dA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qph TRMB, A GLOBAL
TRANSCRIPTION
REGULATOR

(Pyrococcus
furiosus) 		PF01978
(TrmB)
PF11495
(Regulator_TrmB) 		4 PHE A 144
ILE A 165
VAL A 182
PHE A 180
 None
 0.98A 2cizA-3qphA:
undetectable		 2cizA-3qphA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT M
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N

(Escherichia
coli;
Escherichia
coli) 		no annotation
no annotation 		4 PHE M  75
ILE N 475
VAL N 328
GLU N 324
 None
 0.92A 2cizA-3rkoM:
undetectable		 2cizA-3rkoM:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tg9 PENICILLIN-BINDING
PROTEIN

(Bacillus
halodurans) 		PF00144
(Beta-lactamase) 		4 ALA A 228
VAL A 174
GLU A 175
PHE A 179
 None
 0.59A 2cizA-3tg9A:
undetectable		 2cizA-3tg9A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9s OMPR FAMILY RESPONSE
REGULATOR IN
TWO-COMPONENT
REGULATORY SYSTEM
WITH BASS

(Klebsiella
pneumoniae) 		PF00072
(Response_reg) 		4 ALA A  37
PHE A  62
ILE A   6
VAL A  30
 None
 0.89A 2cizA-3w9sA:
undetectable		 2cizA-3w9sA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4avc LYSINE
ACETYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00027
(cNMP_binding)
PF13302
(Acetyltransf_3) 		4 PHE A  57
ILE A  86
VAL A  20
PHE A  21
 None
PEG  A1335 (-4.5A)
PEG  A1335 ( 4.1A)
None
 0.91A 2cizA-4avcA:
undetectable		 2cizA-4avcA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cwe REPLICATION
INITIATION PROTEIN,
REPLICATION
INITIATION PROTEIN

(Staphylococcus
aureus) 		PF02486
(Rep_trans) 		4 ALA A 156
PHE A 179
ILE A 188
VAL A 213
 None
 0.93A 2cizA-4cweA:
undetectable		 2cizA-4cweA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e44 CENTROMERE PROTEIN S
CENTROMERE PROTEIN X

(Homo sapiens;
Homo sapiens) 		PF15630
(CENP-S)
PF09415
(CENP-X) 		4 ALA B  50
PHE A  42
ILE A  47
VAL A  27
 None
 0.91A 2cizA-4e44B:
undetectable		 2cizA-4e44B:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ep0 MAJOR TAIL PROTEIN

(Streptococcus
virus C1) 		PF16838
(Caud_tail_N) 		4 ALA A 311
ILE A 328
VAL A 350
PHE A 334
 None
 0.84A 2cizA-4ep0A:
undetectable		 2cizA-4ep0A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fc8 TRANSCRIPTION
PROTEIN RTR1

(Kluyveromyces
lactis) 		PF04181
(RPAP2_Rtr1) 		4 ALA A 130
ILE A  23
VAL A  26
GLU A  27
 None
 0.81A 2cizA-4fc8A:
undetectable		 2cizA-4fc8A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4leb AGGLUTININ-LIKE
PROTEIN 3

(Candida
albicans) 		PF11766
(Candida_ALS_N) 		4 ALA A  33
ILE A 152
VAL A 141
PHE A 143
 None
 0.93A 2cizA-4lebA:
undetectable		 2cizA-4lebA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0k ADENINE
PHOSPHORIBOSYLTRANSF
ERASE

(Rhodothermus
marinus) 		PF00156
(Pribosyltran) 		4 ALA A 135
ILE A  61
VAL A  83
GLU A  62
 None
None
None
AMP  A 300 (-4.0A)
 0.94A 2cizA-4m0kA:
undetectable		 2cizA-4m0kA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m3o KLLA0F12672P

(Kluyveromyces
lactis) 		PF04181
(RPAP2_Rtr1) 		4 ALA A 130
ILE A  23
VAL A  26
GLU A  27
 None
 0.89A 2cizA-4m3oA:
undetectable		 2cizA-4m3oA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mp3 PUTATIVE ORNITHINE
CYCLODEAMINASE

(Staphylococcus
aureus) 		PF02423
(OCD_Mu_crystall) 		4 ALA A 130
PHE A 231
ILE A 302
VAL A 252
 None
 0.98A 2cizA-4mp3A:
undetectable		 2cizA-4mp3A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p2c SHIGA TOXIN 2E,
SUBUNIT B

(Escherichia
coli) 		PF02258
(SLT_beta) 		4 PHE B  62
ILE B  51
VAL B  49
PHE B  67
 None
 0.94A 2cizA-4p2cB:
undetectable		 2cizA-4p2cB:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxb UREIDOGLYCOLATE
HYDROLASE

(Arabidopsis
thaliana) 		PF01546
(Peptidase_M20) 		4 ALA A 422
ILE A 419
VAL A 271
PHE A 439
 UGC  A 503 (-3.4A)
None
None
None
 0.94A 2cizA-4pxbA:
undetectable		 2cizA-4pxbA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r84 SIALYLTRANSFERASE
0160

(Photobacterium
damselae) 		PF11477
(PM0188) 		4 ALA A 441
PHE A 353
ILE A 378
VAL A 377
 None
 0.90A 2cizA-4r84A:
undetectable		 2cizA-4r84A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9v SIALYLTRANSFERASE
0160

(Photobacterium
damselae) 		PF11477
(PM0188) 		4 ALA A 441
PHE A 353
ILE A 378
VAL A 377
 None
 0.94A 2cizA-4r9vA:
undetectable		 2cizA-4r9vA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4raf PROTEIN PHOSPHATASE
1A

(Homo sapiens) 		PF00481
(PP2C)
PF07830
(PP2C_C) 		4 PHE A 291
ILE A 134
VAL A 132
PHE A 141
 None
 0.92A 2cizA-4rafA:
undetectable		 2cizA-4rafA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rld ASPARTIC PROTEASE
BLA G 2

(Blattella
germanica) 		PF00026
(Asp) 		4 PHE A  31
ILE A 123
VAL A 136
PHE A 140
 None
 0.95A 2cizA-4rldA:
undetectable		 2cizA-4rldA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xaj MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NUCLEAR
RECEPTOR SUBFAMILY 2
GROUP E MEMBER 1

(Escherichia
coli;
Homo sapiens) 		PF00104
(Hormone_recep)
PF13416
(SBP_bac_8) 		4 ALA A1189
PHE A1226
ILE A1230
VAL A1237
 None
 0.91A 2cizA-4xajA:
undetectable		 2cizA-4xajA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xg1 DIAMINOPIMELATE
DECARBOXYLASE

(Psychromonas
ingrahamii) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 ALA A 115
PHE A 123
ILE A 134
VAL A 137
 None
 0.97A 2cizA-4xg1A:
undetectable		 2cizA-4xg1A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhb IRON-CHELATOR
UTILIZATION PROTEIN

(Thermobifida
fusca) 		PF04954
(SIP)
PF08021
(FAD_binding_9) 		4 ALA A 155
PHE A 172
ILE A 191
VAL A 168
 None
 0.96A 2cizA-4yhbA:
undetectable		 2cizA-4yhbA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aoc ESTERASE

(Thermogutta
terrifontis) 		PF07859
(Abhydrolase_3) 		4 ALA A 268
PHE A  70
ILE A  47
PHE A 160
 None
 0.98A 2cizA-5aocA:
undetectable		 2cizA-5aocA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cej 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE

(Yersinia pestis) 		PF13561
(adh_short_C2) 		4 ALA A 220
PHE A   3
ILE A  82
VAL A  84
 None
 0.98A 2cizA-5cejA:
undetectable		 2cizA-5cejA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czw MYROILYSIN

(Myroides
profundi) 		PF01400
(Astacin) 		4 ALA A  73
ILE A  54
VAL A  56
PHE A  86
 MLY  A  70 ( 3.8A)
None
None
MLY  A  70 ( 4.0A)
 0.94A 2cizA-5czwA:
undetectable		 2cizA-5czwA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dih MICROCOMPARTMENTS
PROTEIN

(Haliangium
ochraceum) 		PF00936
(BMC) 		4 ALA A 139
ILE A 122
VAL A 124
PHE A 162
 None
 0.88A 2cizA-5dihA:
undetectable		 2cizA-5dihA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dir LIPOPROTEIN SIGNAL
PEPTIDASE

(Pseudomonas
aeruginosa) 		PF01252
(Peptidase_A8) 		4 PHE A  30
ILE A  40
VAL A  42
PHE A  47
 OLC  A 207 ( 4.8A)
OLC  A 207 (-4.6A)
OLC  A 208 ( 4.3A)
None
 0.83A 2cizA-5dirA:
undetectable		 2cizA-5dirA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dje ZUOTIN

(Saccharomyces
cerevisiae) 		no annotation 4 ALA A 116
PHE A  21
VAL A  28
PHE A  29
 None
 0.95A 2cizA-5djeA:
undetectable		 2cizA-5djeA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7p CELL DIVISION
CONTROL PROTEIN
CDC48

(Mycolicibacterium
smegmatis) 		PF00004
(AAA)
PF02359
(CDC48_N) 		4 ALA A 277
PHE A 324
ILE A 364
VAL A 268
 ADP  A 901 (-3.4A)
None
None
None
 0.84A 2cizA-5e7pA:
undetectable		 2cizA-5e7pA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fuk MROUPO

(Marasmius
rotula) 		PF01328
(Peroxidase_2) 		4 ALA A  59
ILE A 153
GLU A 157
PHE A 160
 PLM  A1237 (-3.5A)
RNP  A1238 ( 4.2A)
HEM  A1235 ( 3.4A)
PLM  A1237 ( 4.0A)
 0.41A 2cizA-5fukA:
26.8		 2cizA-5fukA:
28.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsz KINESIN-LIKE PROTEIN
KIF19

(Mus musculus) 		PF00225
(Kinesin) 		4 ALA A  83
PHE A  71
ILE A 320
VAL A 318
 None
 0.88A 2cizA-5gszA:
undetectable		 2cizA-5gszA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3o CYCLIC
NUCLEOTIDE-GATED
CATION CHANNEL

(Caenorhabditis
elegans) 		PF00027
(cNMP_binding)
PF00520
(Ion_trans)
PF16526
(CLZ) 		4 ALA A 324
ILE A 140
VAL A 144
PHE A 145
 None
 0.67A 2cizA-5h3oA:
undetectable		 2cizA-5h3oA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jtv UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7

(Homo sapiens) 		PF00443
(UCH)
PF14533
(USP7_C2) 		4 PHE A1063
ILE A1011
VAL A1020
PHE A1017
 None
 0.82A 2cizA-5jtvA:
undetectable		 2cizA-5jtvA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B

(Mus musculus) 		PF00149
(Metallophos) 		4 PHE A 143
ILE A 150
VAL A 154
PHE A 170
 None
 0.95A 2cizA-5karA:
undetectable		 2cizA-5karA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kkp PSEUDOURIDYLATE
SYNTHASE 7

(Homo sapiens) 		PF01142
(TruD) 		4 ALA A 635
PHE A 627
VAL A 139
PHE A 137
 None
 0.93A 2cizA-5kkpA:
undetectable		 2cizA-5kkpA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ll7 BETA-LACTAMASE

(Escherichia
coli) 		no annotation 4 ALA A 286
PHE A  33
ILE A  44
VAL A 263
 None
 0.97A 2cizA-5ll7A:
undetectable		 2cizA-5ll7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ly8 TAIL COMPONENT

(Lactobacillus
phage J-1) 		no annotation 4 ALA A 124
PHE A 181
VAL A 198
PHE A 201
 None
 0.98A 2cizA-5ly8A:
undetectable		 2cizA-5ly8A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mun LYS-GINGIPAIN W83

(Porphyromonas
gingivalis) 		PF08126
(Propeptide_C25) 		4 PHE A  47
ILE A 194
VAL A 196
PHE A  43
 None
 0.71A 2cizA-5munA:
undetectable		 2cizA-5munA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncl CBK1 KINASE
ACTIVATOR PROTEIN
MOB2

(Saccharomyces
cerevisiae) 		no annotation 4 ALA B 127
ILE B 218
VAL B 215
PHE B 211
 None
 0.97A 2cizA-5nclB:
undetectable		 2cizA-5nclB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nny WIPB

(Legionella
pneumophila) 		no annotation 4 PHE A 322
ILE A 226
VAL A 228
PHE A 326
 None
 0.79A 2cizA-5nnyA:
undetectable		 2cizA-5nnyA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uen ADENOSINE RECEPTOR
A1,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A1

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		4 ALA A 237
ILE A 199
VAL A 203
PHE A 204
 None
 0.97A 2cizA-5uenA:
undetectable		 2cizA-5uenA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5umu FACT COMPLEX SUBUNIT
SPT16

(Homo sapiens) 		no annotation 4 ALA A 707
ILE A 784
VAL A 787
GLU A 788
 None
 0.86A 2cizA-5umuA:
undetectable		 2cizA-5umuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vye L-THREONINE ALDOLASE

(Pseudomonas
putida) 		no annotation 4 ALA A 224
PHE A  59
ILE A 216
VAL A 200
 None
 0.89A 2cizA-5vyeA:
undetectable		 2cizA-5vyeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wl3 ENGINEERED CHALCONE
ISOMERASE ANCR2

(unidentified) 		no annotation 4 PHE A 133
ILE A 112
VAL A 188
PHE A 189
 None
None
None
CL  A 301 (-4.9A)
 0.72A 2cizA-5wl3A:
undetectable		 2cizA-5wl3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3p AMY13K

([Eubacterium]
rectale) 		no annotation 4 PHE A 345
ILE A 356
VAL A 358
PHE A 341
 None
 0.92A 2cizA-6b3pA:
undetectable		 2cizA-6b3pA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b67 PROTEIN PHOSPHATASE
1A

(Homo sapiens) 		no annotation 4 PHE A 291
ILE A 134
VAL A 132
PHE A 141
 None
 0.95A 2cizA-6b67A:
undetectable		 2cizA-6b67A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bwy PROTECTION OF
TELOMERES PROTEIN 1,
DNA DC->
DU-EDITING ENZYME
APOBEC-3G FUSION

(Schizosaccharomyces
pombe;
Homo sapiens) 		no annotation 4 ALA A 182
PHE A  66
ILE A  42
GLU A 178
 None
 0.95A 2cizA-6bwyA:
undetectable		 2cizA-6bwyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0f RIBOSOME PRODUCTION
FACTOR 1

(Saccharomyces
cerevisiae) 		no annotation 4 PHE I 110
ILE I 150
VAL I 148
PHE I 162
 None
 0.87A 2cizA-6c0fI:
undetectable		 2cizA-6c0fI:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cau UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE

(Acinetobacter
baumannii) 		no annotation 4 ALA A 300
ILE A 261
VAL A 277
PHE A 275
 None
 0.98A 2cizA-6cauA:
undetectable		 2cizA-6cauA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cri -

(-) 		no annotation 4 ALA G 139
PHE G 175
ILE G 165
VAL G 168
 None
 0.89A 2cizA-6criG:
undetectable		 2cizA-6criG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
4, MITOCHONDRIAL

(Mus musculus) 		no annotation 4 PHE Q  86
ILE Q  37
VAL Q  35
PHE Q  59
 None
 0.71A 2cizA-6g2jQ:
undetectable		 2cizA-6g2jQ:
undetectable