SIMILAR PATTERNS OF AMINO ACIDS FOR 2CEO_B_T44B1395_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dkp PHYTASE

(Escherichia
coli) 		PF00328
(His_Phos_2) 		5 ALA A 313
LEU A 124
LEU A 310
ASN A 306
ARG A 267
 None
None
None
None
IHP  A 550 (-3.9A)
 1.39A 2ceoB-1dkpA:
0.0		 2ceoB-1dkpA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0p ANTIGEN 85-B

(Mycobacterium
tuberculosis) 		PF00756
(Esterase) 		5 ALA A 121
GLN A 270
LEU A 149
LEU A 278
ARG A 206
 None
None
None
None
MES  A1101 (-3.5A)
 1.36A 2ceoB-1f0pA:
0.0		 2ceoB-1f0pA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gaj HIGH-AFFINITY
BRANCHED CHAIN AMINO
ACID TRANSPORT
ATP-BINDING PROTEIN

(Methanocaldococcus
jannaschii) 		PF00005
(ABC_tran) 		5 ALA A 134
GLN A 158
LEU A 154
LEU A 138
ARG A 149
 None
 1.37A 2ceoB-1gajA:
0.0		 2ceoB-1gajA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mu2 HIV-2 RT

(Human
immunodeficiency
virus 2) 		PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		5 ALA B 101
GLN B 343
LEU B 325
LEU B 348
ARG B 384
 None
None
None
SO4  B1309 ( 3.6A)
None
 1.13A 2ceoB-1mu2B:
0.0		 2ceoB-1mu2B:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nl4 PROTEIN
FARNESYLTRANSFERASE
ALPHA SUBUNIT

(Rattus
norvegicus) 		PF01239
(PPTA) 		5 ALA A 202
GLN A 225
LEU A 226
LEU A 193
ASN A 194
 None
 1.38A 2ceoB-1nl4A:
0.0		 2ceoB-1nl4A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nne DNA MISMATCH REPAIR
PROTEIN MUTS

(Thermus
aquaticus) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		5 ALA A  93
LEU A  54
LEU A  50
LEU A  33
ARG A  84
 None
 1.37A 2ceoB-1nneA:
undetectable		 2ceoB-1nneA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qq6 PROTEIN
(L-2-HALOACID
DEHALOGENASE)

(Xanthobacter
autotrophicus) 		PF00702
(Hydrolase) 		5 ALA A 197
GLN A  36
LEU A 210
SER A 194
LEU A 193
 None
 0.81A 2ceoB-1qq6A:
0.0		 2ceoB-1qq6A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ser PROTEIN (SERYL-TRNA
SYNTHETASE
(E.C.6.1.1.11))

(Thermus
thermophilus) 		PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N) 		5 ALA A 360
LEU A 244
LEU A 246
SER A 235
ARG A 363
 None
 1.30A 2ceoB-1serA:
0.0		 2ceoB-1serA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
RE-EXPORTER

(Saccharomyces
cerevisiae) 		PF03378
(CAS_CSE1)
PF03810
(IBN_N)
PF08506
(Cse1) 		5 ALA C 867
LEU C 938
SER C 868
LEU C 956
ASN C 954
 None
 1.27A 2ceoB-1wa5C:
0.0		 2ceoB-1wa5C:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wfj PUTATIVE
ELICITOR-RESPONSIVE
GENE

(Arabidopsis
thaliana) 		PF00168
(C2) 		5 ALA A  19
LEU A  73
LEU A  37
SER A  18
LEU A  16
 None
 1.31A 2ceoB-1wfjA:
undetectable		 2ceoB-1wfjA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wls L-ASPARAGINASE

(Pyrococcus
horikoshii) 		PF00710
(Asparaginase) 		5 ALA A  44
LEU A 128
SER A  28
LEU A  31
LYS A  32
 None
 1.14A 2ceoB-1wlsA:
undetectable		 2ceoB-1wlsA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkw FE(III)-PYOCHELIN
RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 ALA A 102
LEU A 133
LEU A 140
LEU A  99
ARG A 180
 None
 1.17A 2ceoB-1xkwA:
undetectable		 2ceoB-1xkwA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xt0 GUANINE NUCLEOTIDE
EXCHANGE PROTEIN

(Legionella
pneumophila) 		PF01369
(Sec7) 		5 LEU B 194
LEU B  95
SER B  63
LEU B 110
LYS B 106
 None
 1.33A 2ceoB-1xt0B:
undetectable		 2ceoB-1xt0B:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2am2 UDP-N-ACETYLMURAMOYL
ALANINE-D-GLUTAMYL-L
YSINE-D-ALANYL-D-ALA
NINE LIGASE, MURF
PROTEIN

(Streptococcus
pneumoniae) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 LEU A 321
LEU A 436
SER A 374
LEU A 336
LYS A 333
 None
 1.41A 2ceoB-2am2A:
undetectable		 2ceoB-2am2A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Thermus
thermophilus) 		PF01409
(tRNA-synt_2d)
PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		5 ALA B 179
LEU B   8
LEU B 173
LEU B  28
ARG B  24
 None
 1.29A 2ceoB-2amcB:
undetectable		 2ceoB-2amcB:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cg5 L-AMINOADIPATE-SEMIA
LDEHYDE
DEHYDROGENASE-PHOSPH
OPANTETHEINYL
TRANSFERASE

(Homo sapiens) 		PF01648
(ACPS) 		5 ALA A 130
LEU A  94
LEU A 104
LYS A  84
ARG A  78
 None
MG  A1301 ( 4.9A)
None
None
MG  A1301 (-4.2A)
 1.13A 2ceoB-2cg5A:
undetectable		 2ceoB-2cg5A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cx9 ACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 ALA A 282
GLN A 261
LEU A 264
SER A 288
LEU A 291
 None
 1.26A 2ceoB-2cx9A:
undetectable		 2ceoB-2cx9A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gl8 RETINOIC ACID
RECEPTOR RXR-GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ALA A 159
LEU A 171
LEU A  71
LEU A 162
ASN A 164
 None
 1.36A 2ceoB-2gl8A:
undetectable		 2ceoB-2gl8A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gm2 CONSERVED
HYPOTHETICAL PROTEIN

(Xanthomonas
campestris) 		PF04430
(DUF498) 		5 ALA A  17
LEU A  40
LEU A  35
LEU A  14
ASN A  25
 None
 1.40A 2ceoB-2gm2A:
undetectable		 2ceoB-2gm2A:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h4t CARNITINE
O-PALMITOYLTRANSFERA
SE II, MITOCHONDRIAL

(Rattus
norvegicus) 		PF00755
(Carn_acyltransf) 		5 ALA A 430
LEU A 419
LEU A 306
SER A 293
LEU A 291
 None
 1.33A 2ceoB-2h4tA:
undetectable		 2ceoB-2h4tA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnh DNA POLYMERASE III
ALPHA SUBUNIT

(Escherichia
coli) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		5 ALA A 776
GLN A 610
LEU A 611
SER A 596
LEU A 772
 None
 1.25A 2ceoB-2hnhA:
undetectable		 2ceoB-2hnhA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxo PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		5 ALA A  66
LEU A  45
LEU A  41
LEU A  62
ARG A  19
 None
 1.27A 2ceoB-2hxoA:
undetectable		 2ceoB-2hxoA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inp PHENOL HYDROXYLASE
COMPONENT PHL

(Pseudomonas
stutzeri) 		PF02332
(Phenol_Hydrox) 		5 ALA C 313
LEU C 126
LEU C 300
LEU C 229
LYS C 233
 None
 1.41A 2ceoB-2inpC:
undetectable		 2ceoB-2inpC:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kvv PUTATIVE EXCISIONASE

(Klebsiella
pneumoniae) 		PF06806
(DUF1233) 		5 ALA A  34
LEU A  16
LEU A  22
LYS A  65
ASN A  64
 None
 1.36A 2ceoB-2kvvA:
undetectable		 2ceoB-2kvvA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l3g RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 7

(Homo sapiens) 		PF00307
(CH) 		5 LEU A  24
LEU A  58
SER A 113
LEU A 117
ASN A 118
 None
 1.35A 2ceoB-2l3gA:
undetectable		 2ceoB-2l3gA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq2 HYPOTHETICAL ABC
TRANSPORTER
ATP-BINDING PROTEIN
HI1470

(Haemophilus
influenzae) 		PF00005
(ABC_tran) 		5 ALA C 109
GLN C 133
LEU C 129
LEU C 113
ARG C 124
 None
 1.31A 2ceoB-2nq2C:
undetectable		 2ceoB-2nq2C:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nwi HYPOTHETICAL PROTEIN

(Archaeoglobus
fulgidus) 		PF01947
(DUF98) 		5 ALA A 107
LEU A  89
LEU A  81
LEU A 148
ARG A  58
 None
 1.36A 2ceoB-2nwiA:
undetectable		 2ceoB-2nwiA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8v PHOSPHOADENOSINE
PHOSPHOSULFATE
REDUCTASE

(Escherichia
coli) 		PF01507
(PAPS_reduct) 		5 LEU A  28
LEU A 170
LEU A   4
LYS A   2
ASN A  43
 None
 1.32A 2ceoB-2o8vA:
undetectable		 2ceoB-2o8vA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rcc RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA

(Bacillus
halodurans) 		PF00268
(Ribonuc_red_sm) 		5 ALA A  40
LEU A 233
SER A 106
LEU A 107
ARG A  36
 None
 1.31A 2ceoB-2rccA:
undetectable		 2ceoB-2rccA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rd9 BH0186 PROTEIN

(Bacillus
halodurans) 		PF12867
(DinB_2) 		5 LEU A  65
LEU A  61
SER A 137
LEU A 136
ARG A 120
 None
 1.22A 2ceoB-2rd9A:
undetectable		 2ceoB-2rd9A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhk NON-STRUCTURAL
PROTEIN 1

(Influenza A
virus) 		PF00600
(Flu_NS1) 		5 ALA A 155
LEU A 181
LEU A 130
LYS A 126
ASN A 190
 NO3  A   2 ( 3.7A)
None
None
NO3  A   2 (-2.7A)
None
 1.12A 2ceoB-2rhkA:
undetectable		 2ceoB-2rhkA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ri8 MANNOSYL-OLIGOSACCHA
RIDE
ALPHA-1,2-MANNOSIDAS
E

(Penicillium
citrinum) 		PF01532
(Glyco_hydro_47) 		5 ALA A1436
GLN A1465
LEU A1469
LEU A1406
SER A1439
 None
 1.41A 2ceoB-2ri8A:
undetectable		 2ceoB-2ri8A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 LEU A 606
LEU A 642
SER A 634
LEU A 631
ARG A 590
 None
 1.10A 2ceoB-2vdcA:
undetectable		 2ceoB-2vdcA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2g NON-STRUCTURAL
PROTEIN 3

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF11633
(SUD-M) 		5 ALA A 503
LEU A 412
SER A 472
LEU A 475
LYS A 476
 None
 1.06A 2ceoB-2w2gA:
undetectable		 2ceoB-2w2gA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wl3 CATECHOL
2,3-DIOXYGENASE

(Rhodococcus sp.
DK17) 		PF00903
(Glyoxalase) 		5 ALA A  63
LEU A 147
LEU A 213
SER A  13
LEU A  12
 None
 1.30A 2ceoB-2wl3A:
undetectable		 2ceoB-2wl3A:
20.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xn6 THYROXINE-BINDING
GLOBULIN

(Homo sapiens) 		PF00079
(Serpin) 		7 ALA A  27
GLN A 238
LEU A 246
LEU A 248
LEU A 269
LYS A 270
ASN A 273
 T44  A1370 ( 3.9A)
T44  A1370 (-3.3A)
T44  A1370 (-4.6A)
None
T44  A1370 (-4.0A)
T44  A1370 (-4.8A)
T44  A1370 ( 3.3A)
 0.43A 2ceoB-2xn6A:
41.4		 2ceoB-2xn6A:
86.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xn6 THYROXINE-BINDING
GLOBULIN

(Homo sapiens) 		PF00079
(Serpin) 		7 ALA A  27
GLN A 238
LEU A 246
LEU A 248
SER A 266
LEU A 269
ASN A 273
 T44  A1370 ( 3.9A)
T44  A1370 (-3.3A)
T44  A1370 (-4.6A)
None
T44  A1370 ( 4.1A)
T44  A1370 (-4.0A)
T44  A1370 ( 3.3A)
 0.56A 2ceoB-2xn6A:
41.4		 2ceoB-2xn6A:
86.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3att PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
tuberculosis) 		PF01636
(APH) 		5 ALA A 250
GLN A 316
LEU A 323
LEU A 173
ARG A 312
 None
 1.34A 2ceoB-3attA:
undetectable		 2ceoB-3attA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cdi POLYNUCLEOTIDE
PHOSPHORYLASE

(Escherichia
coli) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		5 ALA A 322
LEU A 304
LEU A 316
ASN A 262
ARG A 268
 None
 1.30A 2ceoB-3cdiA:
undetectable		 2ceoB-3cdiA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dad FH1/FH2
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		no annotation 5 GLN A  91
LEU A  82
LEU A  51
SER A  44
LEU A  45
 None
 1.41A 2ceoB-3dadA:
undetectable		 2ceoB-3dadA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g06 SSPH2 (LEUCINE-RICH
REPEAT PROTEIN)

(Salmonella
enterica) 		PF14496
(NEL) 		5 ALA A 711
LEU A 609
LEU A 777
LEU A 707
ARG A 709
 None
 1.15A 2ceoB-3g06A:
undetectable		 2ceoB-3g06A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gkq TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE
1,9A-DIOXYGENASE

(Sphingomonas
sp. KA1) 		PF00355
(Rieske)
PF11723
(Aromatic_hydrox) 		5 ALA A 370
GLN A 378
LEU A  52
SER A 371
ARG A 175
 None
 1.38A 2ceoB-3gkqA:
undetectable		 2ceoB-3gkqA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gsz RNA-DIRECTED RNA
POLYMERASE

(Hepacivirus C) 		PF00998
(RdRP_3) 		5 LEU A 489
LEU A 497
SER A 478
LEU A 482
ARG A 484
 None
 1.39A 2ceoB-3gszA:
undetectable		 2ceoB-3gszA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5a RESPONSE
REGULATOR/GGDEF
DOMAIN PROTEIN

(Pseudomonas
syringae group
genomosp. 3) 		PF00072
(Response_reg)
PF00990
(GGDEF) 		5 ALA A 233
LEU A 257
LEU A 204
SER A 275
LEU A 272
 None
C2E  A 335 ( 3.6A)
None
None
None
 0.98A 2ceoB-3i5aA:
undetectable		 2ceoB-3i5aA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icv LIPASE B

(Moesziomyces
antarcticus) 		no annotation 5 ALA A 166
LEU A  70
LEU A 136
SER A 261
ASN A  85
 None
 1.27A 2ceoB-3icvA:
undetectable		 2ceoB-3icvA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kqf ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF00378
(ECH_1) 		5 ALA A 104
LEU A  42
LEU A  38
SER A 118
LEU A 117
 None
 1.34A 2ceoB-3kqfA:
undetectable		 2ceoB-3kqfA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lez BETA-LACTAMASE

(Oceanobacillus
iheyensis) 		PF13354
(Beta-lactamase2) 		5 ALA A 139
LEU A 104
LEU A 132
LEU A 151
ARG A 216
 None
None
None
None
CA  A   3 ( 4.8A)
 1.00A 2ceoB-3lezA:
undetectable		 2ceoB-3lezA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n5m ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Bacillus
anthracis) 		PF00202
(Aminotran_3) 		5 ALA A 292
GLN A  74
SER A 291
LEU A 290
ASN A 321
 None
 1.36A 2ceoB-3n5mA:
undetectable		 2ceoB-3n5mA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE

(Escherichia
coli) 		PF02784
(Orn_Arg_deC_N) 		5 GLN A 460
LEU A 477
LEU A 463
SER A 416
LEU A 417
 None
 1.39A 2ceoB-3nzqA:
undetectable		 2ceoB-3nzqA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o65 PUTATIVE
ATAXIN-3-LIKE
PROTEIN

(Homo sapiens) 		PF02099
(Josephin) 		5 LEU A  23
SER A  82
LEU A  85
LYS A  86
ARG A 111
 None
 1.30A 2ceoB-3o65A:
undetectable		 2ceoB-3o65A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o65 PUTATIVE
ATAXIN-3-LIKE
PROTEIN

(Homo sapiens) 		PF02099
(Josephin) 		5 LEU A  24
SER A  82
LEU A  85
LYS A  86
ARG A 111
 None
 1.25A 2ceoB-3o65A:
undetectable		 2ceoB-3o65A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o65 PUTATIVE
ATAXIN-3-LIKE
PROTEIN

(Homo sapiens) 		PF02099
(Josephin) 		5 LEU A 170
LEU A  24
SER A  82
LEU A  85
ARG A 111
 None
 1.18A 2ceoB-3o65A:
undetectable		 2ceoB-3o65A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o9t NONSTRUCTURAL
PROTEIN 1

(Influenza A
virus) 		PF00600
(Flu_NS1) 		5 ALA A 155
LEU A 181
LEU A 130
LYS A 126
ASN A 190
 None
 1.15A 2ceoB-3o9tA:
undetectable		 2ceoB-3o9tA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oja LEUCINE-RICH IMMUNE
MOLECULE 1

(Anopheles
gambiae) 		PF00560
(LRR_1) 		5 ALA A  47
LEU A  85
LEU A  76
SER A  43
LEU A  44
 None
 1.32A 2ceoB-3ojaA:
undetectable		 2ceoB-3ojaA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oks 4-AMINOBUTYRATE
TRANSAMINASE

(Mycolicibacterium
smegmatis) 		PF00202
(Aminotran_3) 		5 ALA A 302
GLN A  85
SER A 301
LEU A 300
ASN A 325
 None
 1.40A 2ceoB-3oksA:
undetectable		 2ceoB-3oksA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3prx COBRA VENOM FACTOR

(Naja kaouthia) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		5 LEU B1273
SER B 175
LEU B1298
ASN B1296
ARG B1301
 None
 1.35A 2ceoB-3prxB:
undetectable		 2ceoB-3prxB:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9s OMPR FAMILY RESPONSE
REGULATOR IN
TWO-COMPONENT
REGULATORY SYSTEM
WITH BASS

(Klebsiella
pneumoniae) 		PF00072
(Response_reg) 		5 LEU A 108
LEU A  76
SER A  46
LEU A  47
LYS A   2
 None
 1.25A 2ceoB-3w9sA:
undetectable		 2ceoB-3w9sA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8j IMPORTIN SUBUNIT
ALPHA-1A

(Oryza sativa) 		PF00514
(Arm)
PF01749
(IBB)
PF16186
(Arm_3) 		5 ALA A 262
GLN A 208
LEU A 205
LEU A 209
ASN A 220
 None
 1.39A 2ceoB-4b8jA:
undetectable		 2ceoB-4b8jA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ffc 4-AMINOBUTYRATE
AMINOTRANSFERASE
(GABT)

(Mycobacteroides
abscessus) 		PF00202
(Aminotran_3) 		5 ALA A 300
GLN A  88
SER A 299
LEU A 298
ASN A 323
 None
 1.36A 2ceoB-4ffcA:
undetectable		 2ceoB-4ffcA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gjp HAX3

(Xanthomonas
campestris) 		PF03377
(TAL_effector) 		5 ALA A 298
LEU A 241
SER A 299
LYS A 262
ARG A 249
 None
 1.33A 2ceoB-4gjpA:
undetectable		 2ceoB-4gjpA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h2d NADPH-DEPENDENT
DIFLAVIN
OXIDOREDUCTASE 1

(Homo sapiens) 		PF00258
(Flavodoxin_1) 		5 GLN A  38
LEU A   9
LEU A  48
ASN A  47
ARG A  36
 None
 1.38A 2ceoB-4h2dA:
undetectable		 2ceoB-4h2dA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ha4 BETA-GALACTOSIDASE

(Acidilobus
saccharovorans) 		PF00232
(Glyco_hydro_1) 		5 ALA A 464
LEU A 442
LEU A 425
LEU A  76
ARG A 461
 None
None
None
None
SIN  A 502 (-3.7A)
 1.38A 2ceoB-4ha4A:
undetectable		 2ceoB-4ha4A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j34 KYNURENINE
3-MONOOXYGENASE

(Saccharomyces
cerevisiae) 		PF01494
(FAD_binding_3) 		5 ALA A 282
GLN A 251
LEU A 255
LEU A 266
ASN A 269
 None
 1.27A 2ceoB-4j34A:
undetectable		 2ceoB-4j34A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5u SERINE
HYDROXYMETHYLTRANSFE
RASE

(Rickettsia
rickettsii) 		PF00464
(SHMT) 		5 ALA A 339
LEU A 301
LEU A 363
SER A 335
LEU A 336
 None
 1.39A 2ceoB-4j5uA:
undetectable		 2ceoB-4j5uA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jbe GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE

(Saccharomonospora
viridis) 		PF00171
(Aldedh) 		5 ALA A  34
LEU A 162
SER A 173
LEU A 170
ARG A  41
 ALA  A  34 ( 0.0A)
LEU  A 162 ( 0.6A)
SER  A 173 ( 0.0A)
LEU  A 170 ( 0.6A)
ARG  A  41 ( 0.6A)
 1.35A 2ceoB-4jbeA:
undetectable		 2ceoB-4jbeA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kqk NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE

(Salmonella
enterica) 		PF02277
(DBI_PRT) 		5 ALA A 278
LEU A 153
LEU A   8
ARG A 157
ARG A 255
 None
 1.21A 2ceoB-4kqkA:
undetectable		 2ceoB-4kqkA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kt1 LEUCINE-RICH
REPEAT-CONTAINING
G-PROTEIN COUPLED
RECEPTOR 4

(Homo sapiens) 		PF01462
(LRRNT)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 GLN A 342
LEU A 315
LEU A 338
SER A 351
LEU A 350
 None
 1.33A 2ceoB-4kt1A:
undetectable		 2ceoB-4kt1A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		5 LEU A 533
LEU A 363
LEU A 350
LYS A 351
ARG A 460
 None
 1.34A 2ceoB-4lggA:
undetectable		 2ceoB-4lggA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lnz UNCONVENTIONAL
MYOSIN-VB

(Homo sapiens) 		PF01843
(DIL) 		5 ALA A1620
LEU A1740
LEU A1712
SER A1619
ASN A1696
 None
 1.41A 2ceoB-4lnzA:
undetectable		 2ceoB-4lnzA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbg TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE

(Janthinobacterium
sp. J3) 		PF00355
(Rieske)
PF11723
(Aromatic_hydrox) 		5 ALA A 369
GLN A 377
LEU A  49
SER A 370
ARG A 172
 None
 1.35A 2ceoB-4nbgA:
undetectable		 2ceoB-4nbgA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nqf NUCLEOTIDYLTRANSFERA
SE

(Agrobacterium
fabrum) 		PF05168
(HEPN) 		5 LEU A 284
SER A 226
LEU A 233
ARG A 277
ARG A 223
 None
 1.30A 2ceoB-4nqfA:
undetectable		 2ceoB-4nqfA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p72 PHENYLALANINE--TRNA
LIGASE BETA SUBUNIT

(Pseudomonas
aeruginosa) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		5 LEU A  21
LEU A  25
SER A 170
LEU A 174
ARG A   9
 None
 1.28A 2ceoB-4p72A:
undetectable		 2ceoB-4p72A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r10 PROTEIN HUMPBACK-2

(Caenorhabditis
elegans) 		PF00514
(Arm) 		5 ALA A 201
GLN A 224
SER A 197
LEU A 191
ASN A 189
 None
 1.31A 2ceoB-4r10A:
undetectable		 2ceoB-4r10A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzv HEMOGLOBIN

(Thermobifida
fusca) 		PF01152
(Bac_globin) 		5 LEU A 130
LEU A 140
LEU A  83
ARG A  48
ARG A  80
 None
None
HEM  A1157 (-4.9A)
None
None
 1.21A 2ceoB-4uzvA:
undetectable		 2ceoB-4uzvA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wen K88 FIMBRIAL PROTEIN
AC

(Escherichia
coli) 		PF02432
(Fimbrial_K88) 		5 ALA A 108
LEU A 112
LEU A 255
LEU A  95
ARG A  96
 None
 1.15A 2ceoB-4wenA:
undetectable		 2ceoB-4wenA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhj ENVELOPE
GLYCOPROTEIN H

(Human
alphaherpesvirus
3) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		5 ALA A 202
GLN A 397
LEU A 468
LEU A 433
LEU A 390
 None
 1.40A 2ceoB-4xhjA:
undetectable		 2ceoB-4xhjA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y5j MINI SPINDLES TOG3

(Drosophila
melanogaster) 		no annotation 5 LEU A 601
LEU A 616
SER A 631
LEU A 634
ARG A 641
 None
 1.41A 2ceoB-4y5jA:
undetectable		 2ceoB-4y5jA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bs5 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Acinetobacter
baumannii) 		PF00275
(EPSP_synthase) 		5 LEU A 537
LEU A 493
SER A 530
LEU A 531
ARG A 516
 None
 1.39A 2ceoB-5bs5A:
undetectable		 2ceoB-5bs5A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cio PYRROLOQUINOLINE
QUINONE BIOSYNTHESIS
PROTEIN PQQF

(Serratia sp.
FS14) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 ALA A 477
LEU A 505
LEU A 503
LEU A 523
ASN A 520
 None
 1.06A 2ceoB-5cioA:
undetectable		 2ceoB-5cioA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cww NUCLEOPORIN NUP159
NUCLEOPORIN NUP82

(Chaetomium
thermophilum) 		no annotation 5 ALA B 542
LEU B 423
LEU B 441
SER C1457
LEU C1454
 None
 1.32A 2ceoB-5cwwB:
undetectable		 2ceoB-5cwwB:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dil NON-STRUCTURAL
PROTEIN 1

(Influenza B
virus) 		PF02942
(Flu_B_NS1) 		5 LEU A 209
LEU A 243
SER A 184
LEU A 185
ARG A 186
 None
 1.18A 2ceoB-5dilA:
undetectable		 2ceoB-5dilA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fno MANGANESE
LIPOXYGENASE

(Magnaporthe
oryzae) 		PF00305
(Lipoxygenase) 		5 ALA A 343
LEU A 484
LEU A 510
SER A 224
LEU A 491
 None
 1.40A 2ceoB-5fnoA:
undetectable		 2ceoB-5fnoA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gwo PROBABLE PROTEIN
PHOSPHATASE 2C 50

(Oryza sativa) 		PF00481
(PP2C) 		5 ALA A  84
LEU A  91
SER A 138
LEU A 141
ARG A 108
 None
 1.38A 2ceoB-5gwoA:
undetectable		 2ceoB-5gwoA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb3 NUCLEOPORIN NIC96

(Chaetomium
thermophilum) 		PF04097
(Nic96) 		5 ALA A 960
LEU A 893
LEU A 889
LEU A 946
ARG A 846
 None
 1.19A 2ceoB-5hb3A:
undetectable		 2ceoB-5hb3A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hft GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Klebsiella
pneumoniae) 		PF01019
(G_glu_transpept) 		5 ALA A 125
LEU A 132
LEU A 200
SER A 118
LEU A 115
 None
 1.36A 2ceoB-5hftA:
undetectable		 2ceoB-5hftA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjo UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF08238
(Sel1) 		5 ALA A 213
LEU A 246
LEU A 249
SER A 214
LEU A 268
 None
 0.96A 2ceoB-5jjoA:
undetectable		 2ceoB-5jjoA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jvb PHOSPHONATE ABC
TRANSPORTER,
PERIPLASMIC
PHOSPHONATE-BINDING
PROTEIN

(Trichodesmium
erythraeum) 		no annotation 5 ALA A 227
LEU A 216
LEU A 220
LEU A  43
ARG A 213
 None
 1.40A 2ceoB-5jvbA:
undetectable		 2ceoB-5jvbA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jw6 ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Aspergillus
fumigatus) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		5 ALA A  51
LEU A  34
LEU A  67
SER A  43
LEU A  69
 SO4  A 402 ( 4.4A)
None
None
SO4  A 402 (-2.8A)
None
 1.22A 2ceoB-5jw6A:
undetectable		 2ceoB-5jw6A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4

(Bos taurus) 		PF00361
(Proton_antipo_M)
PF01059
(Oxidored_q5_N) 		5 ALA M 202
GLN M 168
LEU M 174
SER M 157
LEU M 160
 None
 1.32A 2ceoB-5lc5M:
undetectable		 2ceoB-5lc5M:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5meb CELL DIVISION CYCLE
PROTEIN CDT1

(Saccharomyces
cerevisiae) 		PF16679
(CDT1_C) 		5 ALA A 554
LEU A 523
LEU A 520
SER A 555
LEU A 558
 None
 1.25A 2ceoB-5mebA:
undetectable		 2ceoB-5mebA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mus L PROTEIN

(California
reptarenavirus) 		no annotation 5 GLN A1918
LEU A1907
LEU A1902
SER A1747
LEU A1748
 GOL  A2101 (-3.6A)
None
None
None
None
 1.37A 2ceoB-5musA:
undetectable		 2ceoB-5musA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nus P34

(Chaetomium
thermophilum) 		no annotation 5 ALA A  48
LEU A 205
LEU A 237
LEU A 266
ARG A  25
 None
 1.30A 2ceoB-5nusA:
undetectable		 2ceoB-5nusA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nv6 TRANSFORMING GROWTH
FACTOR-BETA-INDUCED
PROTEIN IG-H3

(Homo sapiens) 		PF02469
(Fasciclin) 		5 ALA A 525
LEU A 509
LEU A 518
LEU A 569
LYS A 570
 None
 0.93A 2ceoB-5nv6A:
undetectable		 2ceoB-5nv6A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ALA A 794
GLN A 853
LEU A 850
LEU A 854
LEU A 829
 None
 1.39A 2ceoB-5td2A:
undetectable		 2ceoB-5td2A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujz SCFV

(Homo sapiens) 		PF07686
(V-set) 		5 GLN G   6
LEU G  21
SER G  12
LEU G  11
ASN G 105
 None
 1.36A 2ceoB-5ujzG:
undetectable		 2ceoB-5ujzG:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE

(Thermus
thermophilus) 		no annotation 5 ALA A 602
LEU A 552
LEU A 591
ARG A 597
ARG A 595
 None
None
None
GOL  A3002 (-2.7A)
None
 1.40A 2ceoB-5vopA:
undetectable		 2ceoB-5vopA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7h CYCLOISOMALTOOLIGOSA
CCHARIDE
GLUCANOTRANSFERASE

(Paenibacillus
sp. 598K) 		PF13199
(Glyco_hydro_66)
PF16990
(CBM_35) 		5 ALA A 366
LEU A 392
LEU A 410
SER A 370
LEU A 399
 None
 1.20A 2ceoB-5x7hA:
undetectable		 2ceoB-5x7hA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xpg UNCHARACTERIZED
PROTEIN

(Thermus
thermophilus) 		no annotation 5 LEU A 617
LEU A 619
LEU A 544
ASN A 546
ARG A 651
 None
 1.33A 2ceoB-5xpgA:
undetectable		 2ceoB-5xpgA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y5a KLLA0F20702P

(Kluyveromyces
lactis) 		no annotation 5 ALA A  79
LEU A 148
LEU A 175
SER A  53
ASN A 145
 None
 1.33A 2ceoB-5y5aA:
undetectable		 2ceoB-5y5aA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5v TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5

(Oryctolagus
cuniculus) 		no annotation 5 ALA A 141
LEU A  98
LEU A  83
LEU A 136
ARG A 139
 None
 1.17A 2ceoB-6b5vA:
undetectable		 2ceoB-6b5vA:
12.57