SIMILAR PATTERNS OF AMINO ACIDS FOR 2CBR_A_A80A201
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dci | DIENOYL-COAISOMERASE (Rattusnorvegicus) |
PF00378(ECH_1) | 5 | VAL A 214LEU A 211VAL A 175GLY A 240LEU A 259 | None | 1.18A | 2cbrA-1dciA:undetectable | 2cbrA-1dciA:19.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j93 | UROPORPHYRINOGENDECARBOXYLASE (Nicotianatabacum) |
PF01208(URO-D) | 5 | LEU A 250VAL A 267VAL A 236GLY A 151LEU A 133 | None | 1.14A | 2cbrA-1j93A:undetectable | 2cbrA-1j93A:18.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m3u | 3-METHYL-2-OXOBUTANOATEHYDROXYMETHYLTRANSFERASE (Escherichiacoli) |
PF02548(Pantoate_transf) | 5 | THR A 21THR A 23VAL A 214GLY A 203LEU A 177 | NoneKPL A 265 (-4.1A)KPL A 265 (-4.7A)NoneNone | 1.14A | 2cbrA-1m3uA:undetectable | 2cbrA-1m3uA:21.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n10 | POLLEN ALLERGEN PHLP 1 (Phleum pratense) |
PF01357(Pollen_allerg_1)PF03330(DPBB_1) | 5 | PHE A1106VAL A1090VAL A1138ARG A1137GLY A1069 | None | 0.90A | 2cbrA-1n10A:undetectable | 2cbrA-1n10A:20.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n7u | ADSORPTION PROTEINP2 (Salmonellavirus PRD1) |
PF09214(Prd1-P2) | 5 | VAL A 56LEU A 324THR A 128THR A 319GLY A 373 | NoneNoneNoneNoneACT A 561 ( 4.2A) | 1.18A | 2cbrA-1n7uA:0.9 | 2cbrA-1n7uA:12.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q15 | CARA (Pectobacteriumcarotovorum) |
PF00733(Asn_synthase)PF09147(DUF1933) | 5 | PHE A 124LEU A 402THR A 375VAL A 372GLY A 344 | None | 1.07A | 2cbrA-1q15A:0.0 | 2cbrA-1q15A:13.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1twy | ABC TRANSPORTER,PERIPLASMICSUBSTRATE-BINDINGPROTEIN (Vibrio cholerae) |
PF12727(PBP_like) | 5 | PHE A 159VAL A 177VAL A 147GLY A 125TYR A 233 | None | 1.11A | 2cbrA-1twyA:undetectable | 2cbrA-1twyA:20.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u8v | GAMMA-AMINOBUTYRATEMETABOLISMDEHYDRATASE/ISOMERASE (Clostridiumaminobutyricum) |
PF03241(HpaB)PF11794(HpaB_N) | 5 | PHE A 72VAL A 104THR A 96GLY A 298LEU A 48 | NoneSF4 A 491 ( 4.7A)NoneNoneNone | 1.17A | 2cbrA-1u8vA:undetectable | 2cbrA-1u8vA:18.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1umb | 2-OXO ACIDDEHYDROGENASE BETASUBUNIT (Thermusthermophilus) |
PF02779(Transket_pyr)PF02780(Transketolase_C) | 5 | VAL B 273LEU B 259VAL B 260VAL B 217LEU B 157 | None | 1.11A | 2cbrA-1umbB:undetectable | 2cbrA-1umbB:18.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vft | ALANINE RACEMASE (Streptomyceslavendulae) |
PF00842(Ala_racemase_C)PF01168(Ala_racemase_N) | 5 | VAL A 259LEU A 256VAL A 285VAL A 303ARG A 310 | None | 1.12A | 2cbrA-1vftA:undetectable | 2cbrA-1vftA:17.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vi1 | FATTYACID/PHOSPHOLIPIDSYNTHESIS PROTEINPLSX (Bacillussubtilis) |
PF02504(FA_synthesis) | 5 | PHE A 204LEU A 176VAL A 221VAL A 217GLY A 179 | None | 1.17A | 2cbrA-1vi1A:undetectable | 2cbrA-1vi1A:16.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vl1 | 6-PHOSPHOGLUCONOLACTONASE (Thermotogamaritima) |
PF01182(Glucosamine_iso) | 5 | VAL A 165VAL A 168VAL A 102LEU A 46TYR A 49 | None | 1.07A | 2cbrA-1vl1A:undetectable | 2cbrA-1vl1A:22.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xew | SMC PROTEIN (Pyrococcusfuriosus) |
PF02463(SMC_N) | 5 | VAL X 82VAL X 20THR X 29VAL Y1152GLY X 43 | None | 1.15A | 2cbrA-1xewX:1.3 | 2cbrA-1xewX:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zak | ADENYLATE KINASE (Zea mays) |
PF00406(ADK) | 5 | LEU A 170VAL A 166VAL A 126GLY A 12LEU A 40 | NoneNoneNoneNoneAP5 A 223 (-4.7A) | 1.14A | 2cbrA-1zakA:undetectable | 2cbrA-1zakA:21.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ajr | SUGAR KINASE, PFKBFAMILY (Thermotogamaritima) |
PF00294(PfkB) | 6 | LEU A 52VAL A 54THR A 6THR A 4VAL A 2LEU A 70 | None | 1.45A | 2cbrA-2ajrA:undetectable | 2cbrA-2ajrA:18.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b3x | IRON-RESPONSIVEELEMENT BINDINGPROTEIN 1 (Homo sapiens) |
PF00330(Aconitase)PF00694(Aconitase_C) | 5 | VAL A 130VAL A 498THR A 438THR A 440LEU A 551 | None | 0.99A | 2cbrA-2b3xA:undetectable | 2cbrA-2b3xA:9.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bep | UBIQUITIN-CONJUGATING ENZYME E2-25 KDA (Bos taurus) |
PF00179(UQ_con) | 5 | VAL A 16LEU A 106VAL A 109THR A 77VAL A 73 | None | 0.78A | 2cbrA-2bepA:undetectable | 2cbrA-2bepA:19.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cfm | THERMOSTABLE DNALIGASE (Pyrococcusfuriosus) |
PF01068(DNA_ligase_A_M)PF04675(DNA_ligase_A_N)PF04679(DNA_ligase_A_C) | 6 | VAL A 33LEU A 30VAL A 26THR A 164VAL A 166LEU A 154 | None | 1.34A | 2cbrA-2cfmA:undetectable | 2cbrA-2cfmA:12.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cuk | GLYCERATEDEHYDROGENASE/GLYOXYLATE REDUCTASE (Thermusthermophilus) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C) | 5 | LEU A 225VAL A 197VAL A 150GLY A 231LEU A 98 | None | 1.17A | 2cbrA-2cukA:undetectable | 2cbrA-2cukA:18.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e8g | HYPOTHETICAL PROTEINPH0536 (Pyrococcushorikoshii) |
PF01588(tRNA_bind) | 5 | LEU A 202VAL A 184THR A 158VAL A 169GLY A 207 | None | 1.17A | 2cbrA-2e8gA:undetectable | 2cbrA-2e8gA:20.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gk9 | PHOSPHATIDYLINOSITOL-4-PHOSPHATE5-KINASE, TYPE II,GAMMA (Homo sapiens) |
PF01504(PIP5K) | 5 | PHE A 100LEU A 62THR A 127GLY A 187LEU A 47 | None | 1.06A | 2cbrA-2gk9A:undetectable | 2cbrA-2gk9A:15.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gmh | ELECTRON TRANSFERFLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE (Sus scrofa) |
PF05187(ETF_QO)PF13450(NAD_binding_8) | 5 | LEU A 333THR A 369GLY A 336LEU A 344TYR A 402 | FAD A 611 ( 4.0A)NoneNoneNoneNone | 0.99A | 2cbrA-2gmhA:undetectable | 2cbrA-2gmhA:12.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2go4 | UDP-3-O-[3-HYDROXYMYRISTOYL]N-ACETYLGLUCOSAMINEDEACETYLASE (Aquifexaeolicus) |
PF03331(LpxC) | 5 | VAL A 138LEU A 271VAL A 272THR A 60GLY A 263 | None | 1.11A | 2cbrA-2go4A:undetectable | 2cbrA-2go4A:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ivp | O-SIALOGLYCOPROTEINENDOPEPTIDASE (Pyrococcusabyssi) |
PF00814(Peptidase_M22) | 5 | LEU A 126VAL A 248THR A 243VAL A 240GLY A 147 | None | 0.80A | 2cbrA-2ivpA:undetectable | 2cbrA-2ivpA:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ph0 | UNCHARACTERIZEDPROTEIN (Pectobacteriumcarotovorum) |
PF06228(ChuX_HutX) | 5 | PHE A 137VAL A 32ARG A 113GLY A 15LEU A 146 | None | 1.18A | 2cbrA-2ph0A:undetectable | 2cbrA-2ph0A:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2psb | YERB PROTEIN (Bacillussubtilis) |
PF11258(DUF3048)PF17479(DUF3048_C) | 5 | VAL A 280LEU A 286THR A 293GLY A 257LEU A 92 | None | 1.18A | 2cbrA-2psbA:undetectable | 2cbrA-2psbA:15.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qb6 | EXOPOLYPHOSPHATASE (Saccharomycescerevisiae) |
PF01368(DHH)PF02833(DHHA2) | 5 | VAL A 345LEU A 348VAL A 352THR A 324VAL A 384 | None | 1.18A | 2cbrA-2qb6A:undetectable | 2cbrA-2qb6A:14.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qo3 | ERYAII ERYTHROMYCINPOLYKETIDE SYNTHASEMODULES 3 AND 4 (Saccharopolysporaerythraea) |
PF00109(ketoacyl-synt)PF00698(Acyl_transf_1)PF02801(Ketoacyl-synt_C)PF16197(KAsynt_C_assoc) | 5 | LEU A 273VAL A 132GLY A 227LEU A 96ARG A 41 | None | 0.97A | 2cbrA-2qo3A:undetectable | 2cbrA-2qo3A:9.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vre | DELTA(3,5)-DELTA(2,4)-DIENOYL-COAISOMERASE (Homo sapiens) |
PF00378(ECH_1) | 5 | VAL A 189LEU A 186VAL A 150GLY A 215LEU A 234 | NoneNoneNone CL A1290 ( 3.7A)None | 1.15A | 2cbrA-2vreA:undetectable | 2cbrA-2vreA:17.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wu5 | SUCCINATEDEHYDROGENASEFLAVOPROTEIN SUBUNIT (Escherichiacoli) |
PF00890(FAD_binding_2)PF02910(Succ_DH_flav_C) | 5 | LEU A 408THR A 362VAL A 392GLY A 204LEU A 169 | FAD A 601 (-4.0A)NoneNoneNoneNone | 1.08A | 2cbrA-2wu5A:undetectable | 2cbrA-2wu5A:14.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d2l | SAM-DEPENDENTMETHYLTRANSFERASE (Exiguobacteriumsibiricum) |
PF13649(Methyltransf_25) | 5 | LEU A 27VAL A 23THR A 57GLY A 33LEU A 125 | None | 1.08A | 2cbrA-3d2lA:undetectable | 2cbrA-3d2lA:20.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e9y | ACETOLACTATESYNTHASE,CHLOROPLASTIC (Arabidopsisthaliana) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | VAL A 112LEU A 107VAL A 252GLY A 162TYR A 276 | NoneNoneNoneNoneNHE A 696 (-4.7A) | 1.18A | 2cbrA-3e9yA:undetectable | 2cbrA-3e9yA:13.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f92 | UBIQUITIN-CONJUGATING ENZYME E2 K (Homo sapiens) |
PF00179(UQ_con)PF00627(UBA) | 5 | VAL A 16LEU A 106VAL A 109THR A 77VAL A 73 | None | 0.80A | 2cbrA-3f92A:undetectable | 2cbrA-3f92A:19.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fd0 | PUTATIVECYSTATHIONINEBETA-LYASE INVOLVEDIN ALUMINUMRESISTANCE (Listeriainnocua) |
PF06838(Met_gamma_lyase) | 5 | PHE A 71VAL A 78LEU A 63VAL A 66GLY A 229 | NoneNoneNoneNoneLLP A 226 ( 3.7A) | 1.10A | 2cbrA-3fd0A:undetectable | 2cbrA-3fd0A:15.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3few | COLICIN S4 (Escherichiacoli) |
PF01024(Colicin) | 5 | VAL X 405VAL X 444VAL X 306GLY X 394LEU X 458 | None | 1.17A | 2cbrA-3fewX:undetectable | 2cbrA-3fewX:13.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g68 | PUTATIVEPHOSPHOSUGARISOMERASE (Clostridioidesdifficile) |
PF01380(SIS) | 5 | PHE A 311VAL A 51VAL A 132GLY A 157LEU A 180 | None | 1.11A | 2cbrA-3g68A:undetectable | 2cbrA-3g68A:16.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gq2 | GENERAL VESICULARTRANSPORT FACTORP115 (Bos taurus) |
PF04869(Uso1_p115_head) | 5 | VAL A 373VAL A 366THR A 406GLY A 427LEU A 448 | None | 1.15A | 2cbrA-3gq2A:undetectable | 2cbrA-3gq2A:12.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gyk | 27KDA OUTER MEMBRANEPROTEIN (Ruegeriapomeroyi) |
PF13462(Thioredoxin_4) | 5 | PHE A 6LEU A 53VAL A 51VAL A 165ARG A 2 | None | 1.02A | 2cbrA-3gykA:undetectable | 2cbrA-3gykA:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hvy | CYSTATHIONINEBETA-LYASE FAMILYPROTEIN, YNBBB.SUBTILIS ORTHOLOG (Clostridiumacetobutylicum) |
PF06838(Met_gamma_lyase) | 5 | PHE A 86VAL A 93LEU A 78VAL A 81GLY A 246 | NoneNoneNoneNoneLLP A 243 ( 4.0A) | 1.04A | 2cbrA-3hvyA:undetectable | 2cbrA-3hvyA:15.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i16 | ALUMINUM RESISTANCEPROTEIN (Clostridiumnovyi) |
PF06838(Met_gamma_lyase) | 5 | PHE A 85VAL A 92LEU A 77VAL A 80GLY A 246 | None | 1.04A | 2cbrA-3i16A:undetectable | 2cbrA-3i16A:16.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ij3 | CYTOSOLAMINOPEPTIDASE (Coxiellaburnetii) |
PF00883(Peptidase_M17) | 5 | LEU A 411VAL A 323GLY A 225LEU A 453TYR A 457 | None | 1.04A | 2cbrA-3ij3A:undetectable | 2cbrA-3ij3A:13.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ite | SIDN SIDEROPHORESYNTHETASE (Epichloefestucae) |
PF00501(AMP-binding) | 5 | LEU A 225VAL A 268GLY A 250LEU A 56TYR A 53 | None | 1.13A | 2cbrA-3iteA:undetectable | 2cbrA-3iteA:14.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jzl | PUTATIVECYSTATHIONINEBETA-LYASE INVOLVEDIN ALUMINUMRESISTANCE (Listeriamonocytogenes) |
PF06838(Met_gamma_lyase) | 5 | PHE A 71VAL A 78LEU A 63VAL A 66GLY A 229 | NoneNoneNoneNoneLLP A 226 ( 3.6A) | 1.07A | 2cbrA-3jzlA:undetectable | 2cbrA-3jzlA:14.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m7f | E3 UBIQUITIN-PROTEINLIGASE NEDD4 (Mus musculus) |
PF00168(C2) | 5 | PHE B 178LEU B 188THR B 161VAL B 144ARG B 145 | None | 1.09A | 2cbrA-3m7fB:undetectable | 2cbrA-3m7fB:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n07 | 3-DEOXY-D-MANNO-OCTULOSONATE 8-PHOSPHATEPHOSPHATASE (Vibrio cholerae) |
PF08282(Hydrolase_3) | 5 | VAL A 163VAL A 30VAL A 80ARG A 83GLY A 56 | None | 1.13A | 2cbrA-3n07A:undetectable | 2cbrA-3n07A:18.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r08 | MOUSE ANTI-MOUSECD3EPSILON ANTIBODY2C11 LIGHT CHAIN (Cricetulusmigratorius) |
PF07654(C1-set)PF07686(V-set) | 5 | VAL L 163LEU L 175VAL L 136THR L 200ARG L 108 | None | 1.01A | 2cbrA-3r08L:undetectable | 2cbrA-3r08L:18.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rko | NADH-QUINONEOXIDOREDUCTASESUBUNIT L (Escherichiacoli) |
no annotation | 5 | LEU L 132VAL L 128VAL L 92GLY L 83LEU L 323 | None | 1.06A | 2cbrA-3rkoL:undetectable | 2cbrA-3rkoL:10.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3she | MAP KINASE-ACTIVATEDPROTEIN KINASE 3 (Homo sapiens) |
PF00069(Pkinase) | 5 | LEU A 115VAL A 103VAL A 85GLY A 56LEU A 173 | None | 1.05A | 2cbrA-3sheA:undetectable | 2cbrA-3sheA:17.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3shu | TIGHT JUNCTIONPROTEIN ZO-1 (Homo sapiens) |
PF00595(PDZ) | 5 | VAL A 35LEU A 20VAL A 18VAL A 81GLY A 45 | None | 1.03A | 2cbrA-3shuA:undetectable | 2cbrA-3shuA:27.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u1k | POLYRIBONUCLEOTIDENUCLEOTIDYLTRANSFERASE 1, MITOCHONDRIAL (Homo sapiens) |
PF00013(KH_1)PF01138(RNase_PH)PF03725(RNase_PH_C)PF03726(PNPase) | 5 | VAL A 472LEU A 425THR A 550THR A 555GLY A 490 | None | 1.05A | 2cbrA-3u1kA:undetectable | 2cbrA-3u1kA:13.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uif | SULFONATE ABCTRANSPORTER,PERIPLASMICSULFONATE-BINDINGPROTEIN SSUA (Methylobacillusflagellatus) |
PF09084(NMT1) | 5 | VAL A 251LEU A 248VAL A 244VAL A 114GLY A 118 | NoneNoneNoneNoneGOL A 503 ( 3.8A) | 0.97A | 2cbrA-3uifA:undetectable | 2cbrA-3uifA:16.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uuf | LIP1, SECRETORYLIPASE (FAMILY 3) (Malasseziaglobosa) |
PF01764(Lipase_3) | 5 | VAL A 84VAL A 153VAL A 165GLY A 169TYR A 128 | None | 1.12A | 2cbrA-3uufA:undetectable | 2cbrA-3uufA:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3va7 | KLLA0E08119P (Kluyveromyceslactis) |
PF00289(Biotin_carb_N)PF00364(Biotin_lipoyl)PF02626(CT_A_B)PF02682(CT_C_D)PF02785(Biotin_carb_C)PF02786(CPSase_L_D2) | 5 | PHE A1374VAL A1363LEU A1360GLY A1294TYR A1275 | NoneNoneNoneBTI A1901 ( 3.9A)None | 1.17A | 2cbrA-3va7A:undetectable | 2cbrA-3va7A:8.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3wbg | FATTY ACID-BINDINGPROTEIN, HEART (Homo sapiens) |
PF00061(Lipocalin) | 6 | PHE A 16VAL A 32THR A 53LEU A 115ARG A 126TYR A 128 | 2AN A 201 ( 4.9A)None2AN A 201 ( 4.0A)None2AN A 201 ( 4.9A)None | 0.87A | 2cbrA-3wbgA:19.3 | 2cbrA-3wbgA:39.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wgo | MESO-DIAMINOPIMELATEDEHYDROGENASE (Clostridiumtetani) |
PF16654(DAPDH_C) | 5 | VAL A 305LEU A 130THR A 146VAL A 253GLY A 122 | None | 1.08A | 2cbrA-3wgoA:undetectable | 2cbrA-3wgoA:16.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wwe | OXIDIZED POLYVINYLALCOHOL HYDROLASE (Pseudomonas sp.VM15C) |
no annotation | 5 | VAL A 28VAL A 152THR A 70VAL A 61GLY A 31 | None | 1.14A | 2cbrA-3wweA:undetectable | 2cbrA-3wweA:17.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zlb | PHOSPHOGLYCERATEKINASE (Streptococcuspneumoniae) |
PF00162(PGK) | 5 | VAL A 211LEU A 215VAL A 222THR A 335GLY A 353 | None | 1.17A | 2cbrA-3zlbA:undetectable | 2cbrA-3zlbA:15.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a73 | L-LACTATEDEHYDROGENASE (Thermusthermophilus) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 5 | VAL A 298LEU A 293THR A 169GLY A 162LEU A 315 | None | 1.13A | 2cbrA-4a73A:undetectable | 2cbrA-4a73A:18.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4atw | ALPHA-L-ARABINOFURANOSIDASE DOMAINPROTEIN (Thermotogamaritima) |
PF06964(Alpha-L-AF_C) | 5 | VAL A 260LEU A 263VAL A 267THR A 195GLY A 211 | None | 1.13A | 2cbrA-4atwA:undetectable | 2cbrA-4atwA:13.47 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4azn | FATTY ACID-BINDINGPROTEIN, EPIDERMAL (Mus musculus) |
PF00061(Lipocalin) | 6 | PHE A 19VAL A 28LEU A 32THR A 56ARG A 129TYR A 131 | None | 0.84A | 2cbrA-4aznA:18.8 | 2cbrA-4aznA:34.48 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4azn | FATTY ACID-BINDINGPROTEIN, EPIDERMAL (Mus musculus) |
PF00061(Lipocalin) | 6 | PHE A 19VAL A 28LEU A 32THR A 56GLY A 80TYR A 131 | None | 0.88A | 2cbrA-4aznA:18.8 | 2cbrA-4aznA:34.48 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4azp | FATTY ACID-BINDINGPROTEIN, EPIDERMAL (Mus musculus) |
PF00061(Lipocalin) | 5 | PHE A 19THR A 56VAL A 60ARG A 129TYR A 131 | NoneA9M A1136 ( 4.3A)A9M A1136 (-4.8A)A9M A1136 (-4.3A)A9M A1136 (-4.8A) | 0.71A | 2cbrA-4azpA:19.7 | 2cbrA-4azpA:33.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b92 | DIHYDROPYRIMIDINASE-RELATED PROTEIN 5 (Homo sapiens) |
PF01979(Amidohydro_1) | 5 | PHE A 373VAL A 403VAL A 435THR A 273LEU A 314 | None | 1.16A | 2cbrA-4b92A:undetectable | 2cbrA-4b92A:13.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bpy | SCO PROTEIN (Streptomyceslividans) |
PF02630(SCO1-SenC) | 5 | PHE A 183VAL A 115THR A 178GLY A 153LEU A 47 | None | 1.12A | 2cbrA-4bpyA:undetectable | 2cbrA-4bpyA:19.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c22 | L-FUCOSE ISOMERASE (Streptococcuspneumoniae) |
PF02952(Fucose_iso_C)PF07881(Fucose_iso_N1)PF07882(Fucose_iso_N2) | 5 | VAL A 35VAL A 153THR A 539LEU A 350ARG A 162 | None | 1.18A | 2cbrA-4c22A:undetectable | 2cbrA-4c22A:13.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cak | INTEGRIN ALPHA-IIB (Homo sapiens) |
PF01839(FG-GAP)PF08441(Integrin_alpha2) | 5 | LEU A 786VAL A 748THR A 793VAL A 794GLY A 822 | None | 1.17A | 2cbrA-4cakA:undetectable | 2cbrA-4cakA:8.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4csi | CELLULASE (Humicola grisea) |
PF00840(Glyco_hydro_7) | 5 | VAL A 73THR A 209GLY A 165ARG A 108TYR A 146 | PCA A 1 ( 4.9A)NoneNoneNonePEG A1439 (-3.9A) | 1.02A | 2cbrA-4csiA:undetectable | 2cbrA-4csiA:14.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dzt | AQUALYSIN-1 (Thermusaquaticus) |
PF00082(Peptidase_S8) | 5 | LEU A 137VAL A 141THR A 175VAL A 153GLY A 132 | NoneNone CA A 303 (-3.6A)NoneNone | 1.14A | 2cbrA-4dztA:undetectable | 2cbrA-4dztA:15.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4emd | 4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL KINASE (Mycobacteroidesabscessus) |
PF00288(GHMP_kinases_N)PF08544(GHMP_kinases_C) | 5 | LEU A 24VAL A 42THR A 169VAL A 170GLY A 300 | None | 1.12A | 2cbrA-4emdA:undetectable | 2cbrA-4emdA:18.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i99 | CHROMOSOME PARTITIONPROTEIN SMC (Pyrococcusfuriosus) |
PF02463(SMC_N) | 5 | VAL A 82VAL A 20THR A 29VAL A1152GLY A 43 | None | 1.07A | 2cbrA-4i99A:undetectable | 2cbrA-4i99A:16.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ivi | CARBOXYLESTERASE (unculturedbacterium) |
PF00144(Beta-lactamase) | 5 | VAL A 232LEU A 119VAL A 114GLY A 226LEU A 246 | None | 1.06A | 2cbrA-4iviA:undetectable | 2cbrA-4iviA:18.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k5r | OXYGENASE (Streptomycesargillaceus) |
PF01494(FAD_binding_3) | 5 | VAL A 478LEU A 439VAL A 463VAL A 427GLY A 415 | None | 0.97A | 2cbrA-4k5rA:undetectable | 2cbrA-4k5rA:11.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nfu | EDS1 (Arabidopsisthaliana) |
PF01764(Lipase_3) | 5 | LEU A 93THR A 193VAL A 85GLY A 126LEU A 204 | None | 1.17A | 2cbrA-4nfuA:undetectable | 2cbrA-4nfuA:12.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ou2 | 2-AMINOMUCONATE6-SEMIALDEHYDEDEHYDROGENASE (Pseudomonasfluorescens) |
PF00171(Aldedh) | 5 | LEU A 183VAL A 179THR A 243VAL A 164GLY A 160 | None | 1.12A | 2cbrA-4ou2A:undetectable | 2cbrA-4ou2A:15.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4psn | SSDNA BINDINGPROTEIN (Aeropyrumpernix) |
PF10015(DUF2258) | 5 | VAL A 126THR A 129VAL A 217GLY A 161LEU A 153 | None | 1.00A | 2cbrA-4psnA:2.3 | 2cbrA-4psnA:22.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r0s | PROTEIN TYROSINEPHOSPHATASE TPBA (Pseudomonasaeruginosa) |
PF03162(Y_phosphatase2) | 5 | LEU A 129THR A 34VAL A 43GLY A 135ARG A 147 | NoneNoneNonePO4 A 301 ( 4.5A)None | 1.18A | 2cbrA-4r0sA:undetectable | 2cbrA-4r0sA:21.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rkk | LAFORIN (Homo sapiens) |
PF00686(CBM_20)PF00782(DSPc) | 5 | VAL A 292LEU A 296VAL A 303THR A 238GLY A 279 | None | 1.13A | 2cbrA-4rkkA:undetectable | 2cbrA-4rkkA:16.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rlz | CAPSID PROTEIN (Norwalk virus) |
PF00915(Calici_coat)PF08435(Calici_coat_C) | 5 | PHE A 326VAL A 435THR A 273LEU A 402TYR A 405 | None | 1.18A | 2cbrA-4rlzA:undetectable | 2cbrA-4rlzA:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a0t | RIBONUCLEASE J (Streptomycescoelicolor) |
PF00753(Lactamase_B)PF07521(RMMBL) | 5 | VAL A 149VAL A 159THR A 35VAL A 46LEU A 405 | None | 1.17A | 2cbrA-5a0tA:undetectable | 2cbrA-5a0tA:13.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5auo | ATPASE INVOLVED INCHROMOSOMEPARTITIONING,PARA/MIND FAMILY,MRP HOMOLOG (Thermococcuskodakarensis) |
PF10609(ParA) | 5 | VAL B 43LEU B 40VAL B 36VAL B 185GLY B 246 | None | 0.96A | 2cbrA-5auoB:undetectable | 2cbrA-5auoB:18.85 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5b29 | FATTY ACID-BINDINGPROTEIN, HEART (Homo sapiens) |
PF00061(Lipocalin) | 5 | VAL A 25THR A 53LEU A 115ARG A 126TYR A 128 | NonePLM A 200 ( 4.2A)NonePLM A 200 (-3.7A)PLM A 200 (-4.8A) | 0.80A | 2cbrA-5b29A:19.3 | 2cbrA-5b29A:40.15 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5bvt | EPIDERMAL FATTYACID-BINDING PROTEIN (Pygoscelispapua) |
PF00061(Lipocalin) | 5 | PHE A 19THR A 56GLY A 80ARG A 130TYR A 132 | PAM A 201 ( 4.9A)NoneNonePAM A 201 ( 4.6A)None | 0.86A | 2cbrA-5bvtA:19.1 | 2cbrA-5bvtA:38.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cee | NAD-DEPENDENT MALICENZYME (Aster yellowswitches'-broomphytoplasma) |
PF00390(malic)PF03949(Malic_M) | 5 | VAL A 266LEU A 247VAL A 250VAL A 212GLY A 259 | None | 1.16A | 2cbrA-5ceeA:undetectable | 2cbrA-5ceeA:14.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dfl | UBIQUITIN-CONJUGATING ENZYME E2 K (Homo sapiens) |
PF00179(UQ_con)PF00627(UBA) | 5 | VAL A 16LEU A 106VAL A 109THR A 77VAL A 73 | NoneNoneNoneNoneGOL A 301 (-4.4A) | 0.77A | 2cbrA-5dflA:undetectable | 2cbrA-5dflA:19.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e9a | BETA-GALACTOSIDASE (Rahnella sp. R3) |
PF02449(Glyco_hydro_42)PF08532(Glyco_hydro_42M)PF08533(Glyco_hydro_42C) | 5 | PHE A 606VAL A 448VAL A 434THR A 492LEU A 543 | None | 1.05A | 2cbrA-5e9aA:undetectable | 2cbrA-5e9aA:10.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f4j | PROTRUDING DOMAIN OFGII.17 NOROVIRUSCAPSID (Norwalk virus) |
PF08435(Calici_coat_C) | 5 | PHE A 329VAL A 438THR A 275LEU A 405TYR A 408 | None | 1.17A | 2cbrA-5f4jA:undetectable | 2cbrA-5f4jA:18.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gz1 | MESO-DIAMINOPIMELATED-DEHYDROGENASE (Ureibacillusthermosphaericus) |
PF01113(DapB_N)PF16654(DAPDH_C) | 5 | VAL A 305LEU A 130THR A 146VAL A 253GLY A 122 | None | 1.02A | 2cbrA-5gz1A:undetectable | 2cbrA-5gz1A:19.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i35 | ATYPICAL KINASEADCK3, MITOCHONDRIAL (Homo sapiens) |
PF03109(ABC1) | 5 | VAL A 300LEU A 267VAL A 270GLY A 278TYR A 408 | None | 1.17A | 2cbrA-5i35A:undetectable | 2cbrA-5i35A:15.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i8i | UREA AMIDOLYASE (Kluyveromyceslactis) |
PF00289(Biotin_carb_N)PF01425(Amidase)PF02626(CT_A_B)PF02682(CT_C_D)PF02785(Biotin_carb_C)PF02786(CPSase_L_D2) | 5 | PHE A1374VAL A1363LEU A1360GLY A1294TYR A1275 | None | 1.18A | 2cbrA-5i8iA:undetectable | 2cbrA-5i8iA:5.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nhs | BIFUNCTIONAL PROTEINFOLD (Xanthomonasalbilineans) |
no annotation | 5 | VAL A 238LEU A 217VAL A 174GLY A 229LEU A 246 | None | 1.14A | 2cbrA-5nhsA:undetectable | 2cbrA-5nhsA:19.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nug | CYTOPLASMIC DYNEIN 1HEAVY CHAIN 1 (Homo sapiens) |
PF03028(Dynein_heavy)PF07728(AAA_5)PF08393(DHC_N2)PF12774(AAA_6)PF12775(AAA_7)PF12777(MT)PF12780(AAA_8)PF12781(AAA_9) | 5 | PHE A4145VAL A4055THR A4039ARG A4123GLY A4032 | None | 1.07A | 2cbrA-5nugA:undetectable | 2cbrA-5nugA:2.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o0d | PHOSPHOPANTETHEINEADENYLYLTRANSFERASE (Mycobacteroidesabscessus) |
PF01467(CTP_transf_like) | 5 | LEU A 152VAL A 148VAL A 13ARG A 50GLY A 43 | None | 1.16A | 2cbrA-5o0dA:undetectable | 2cbrA-5o0dA:22.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tzy | FREE FATTY ACIDRECEPTOR1,ENDOLYSIN,FREEFATTY ACID RECEPTOR1 (Escherichiavirus T4;Homo sapiens) |
PF00001(7tm_1)PF00959(Phage_lysozyme) | 5 | VAL A 134LEU A 190GLY A 93LEU A 59TYR A 12 | 7OS A2403 (-4.6A)7OS A2403 (-4.3A)NoneNoneNone | 1.14A | 2cbrA-5tzyA:undetectable | 2cbrA-5tzyA:15.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5udb | DNA REPLICATIONLICENSING FACTORMCM2 (Saccharomycescerevisiae) |
PF00493(MCM)PF14551(MCM_N)PF17207(MCM_OB) | 5 | LEU 2 519VAL 2 515VAL 2 539GLY 2 522LEU 2 834 | None | 1.15A | 2cbrA-5udb2:undetectable | 2cbrA-5udb2:10.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xau | LAMININ SUBUNITALPHA-5 (Homo sapiens) |
PF02210(Laminin_G_2)PF06009(Laminin_II) | 5 | PHE A3258VAL A3288LEU A3133VAL A3265GLY A3291 | None | 1.09A | 2cbrA-5xauA:undetectable | 2cbrA-5xauA:12.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xei | CHROMOSOME PARTITIONPROTEIN SMC (Pyrococcusyayanosii) |
PF02463(SMC_N) | 5 | VAL A 82VAL A 20THR A 29VAL A1152GLY A 43 | None | 1.05A | 2cbrA-5xeiA:undetectable | 2cbrA-5xeiA:13.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c66 | CRISPR-ASSOCIATEDPROTEIN, CAS5EFAMILYCRISPR-ASSOCIATEDPROTEIN, CSE1 FAMILY (Thermobifidafusca) |
no annotation | 5 | VAL M 71LEU M 70VAL M 68GLY A 469LEU A 338 | None | 1.18A | 2cbrA-6c66M:undetectable | 2cbrA-6c66M:17.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6db7 | HUMAN MONOCLONALANTI-HIV-1 GP120 V3ANTIBODY 1334 FABHEAVY CHAIN (Homo sapiens) |
no annotation | 5 | VAL H 67LEU H 82VAL H 18VAL H 109LEU H 4 | None | 1.17A | 2cbrA-6db7H:undetectable | 2cbrA-6db7H:19.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6eqc | SCFV OF 9C12ANTIBODY (Mus musculus) |
no annotation | 5 | VAL D 197LEU D 212VAL D 148THR D 241VAL D 243 | None | 1.07A | 2cbrA-6eqcD:undetectable | 2cbrA-6eqcD:18.94 |