SIMILAR PATTERNS OF AMINO ACIDS FOR 2CBR_A_A80A201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dci DIENOYL-COA
ISOMERASE


(Rattus
norvegicus)
PF00378
(ECH_1)
5 VAL A 214
LEU A 211
VAL A 175
GLY A 240
LEU A 259
None
1.18A 2cbrA-1dciA:
undetectable
2cbrA-1dciA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j93 UROPORPHYRINOGEN
DECARBOXYLASE


(Nicotiana
tabacum)
PF01208
(URO-D)
5 LEU A 250
VAL A 267
VAL A 236
GLY A 151
LEU A 133
None
1.14A 2cbrA-1j93A:
undetectable
2cbrA-1j93A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m3u 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE


(Escherichia
coli)
PF02548
(Pantoate_transf)
5 THR A  21
THR A  23
VAL A 214
GLY A 203
LEU A 177
None
KPL  A 265 (-4.1A)
KPL  A 265 (-4.7A)
None
None
1.14A 2cbrA-1m3uA:
undetectable
2cbrA-1m3uA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n10 POLLEN ALLERGEN PHL
P 1


(Phleum pratense)
PF01357
(Pollen_allerg_1)
PF03330
(DPBB_1)
5 PHE A1106
VAL A1090
VAL A1138
ARG A1137
GLY A1069
None
0.90A 2cbrA-1n10A:
undetectable
2cbrA-1n10A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7u ADSORPTION PROTEIN
P2


(Salmonella
virus PRD1)
PF09214
(Prd1-P2)
5 VAL A  56
LEU A 324
THR A 128
THR A 319
GLY A 373
None
None
None
None
ACT  A 561 ( 4.2A)
1.18A 2cbrA-1n7uA:
0.9
2cbrA-1n7uA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q15 CARA

(Pectobacterium
carotovorum)
PF00733
(Asn_synthase)
PF09147
(DUF1933)
5 PHE A 124
LEU A 402
THR A 375
VAL A 372
GLY A 344
None
1.07A 2cbrA-1q15A:
0.0
2cbrA-1q15A:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1twy ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN


(Vibrio cholerae)
PF12727
(PBP_like)
5 PHE A 159
VAL A 177
VAL A 147
GLY A 125
TYR A 233
None
1.11A 2cbrA-1twyA:
undetectable
2cbrA-1twyA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u8v GAMMA-AMINOBUTYRATE
METABOLISM
DEHYDRATASE/ISOMERAS
E


(Clostridium
aminobutyricum)
PF03241
(HpaB)
PF11794
(HpaB_N)
5 PHE A  72
VAL A 104
THR A  96
GLY A 298
LEU A  48
None
SF4  A 491 ( 4.7A)
None
None
None
1.17A 2cbrA-1u8vA:
undetectable
2cbrA-1u8vA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umb 2-OXO ACID
DEHYDROGENASE BETA
SUBUNIT


(Thermus
thermophilus)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
5 VAL B 273
LEU B 259
VAL B 260
VAL B 217
LEU B 157
None
1.11A 2cbrA-1umbB:
undetectable
2cbrA-1umbB:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vft ALANINE RACEMASE

(Streptomyces
lavendulae)
PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N)
5 VAL A 259
LEU A 256
VAL A 285
VAL A 303
ARG A 310
None
1.12A 2cbrA-1vftA:
undetectable
2cbrA-1vftA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vi1 FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX


(Bacillus
subtilis)
PF02504
(FA_synthesis)
5 PHE A 204
LEU A 176
VAL A 221
VAL A 217
GLY A 179
None
1.17A 2cbrA-1vi1A:
undetectable
2cbrA-1vi1A:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vl1 6-PHOSPHOGLUCONOLACT
ONASE


(Thermotoga
maritima)
PF01182
(Glucosamine_iso)
5 VAL A 165
VAL A 168
VAL A 102
LEU A  46
TYR A  49
None
1.07A 2cbrA-1vl1A:
undetectable
2cbrA-1vl1A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xew SMC PROTEIN

(Pyrococcus
furiosus)
PF02463
(SMC_N)
5 VAL X  82
VAL X  20
THR X  29
VAL Y1152
GLY X  43
None
1.15A 2cbrA-1xewX:
1.3
2cbrA-1xewX:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zak ADENYLATE KINASE

(Zea mays)
PF00406
(ADK)
5 LEU A 170
VAL A 166
VAL A 126
GLY A  12
LEU A  40
None
None
None
None
AP5  A 223 (-4.7A)
1.14A 2cbrA-1zakA:
undetectable
2cbrA-1zakA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ajr SUGAR KINASE, PFKB
FAMILY


(Thermotoga
maritima)
PF00294
(PfkB)
6 LEU A  52
VAL A  54
THR A   6
THR A   4
VAL A   2
LEU A  70
None
1.45A 2cbrA-2ajrA:
undetectable
2cbrA-2ajrA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1


(Homo sapiens)
PF00330
(Aconitase)
PF00694
(Aconitase_C)
5 VAL A 130
VAL A 498
THR A 438
THR A 440
LEU A 551
None
0.99A 2cbrA-2b3xA:
undetectable
2cbrA-2b3xA:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bep UBIQUITIN-CONJUGATIN
G ENZYME E2-25 KDA


(Bos taurus)
PF00179
(UQ_con)
5 VAL A  16
LEU A 106
VAL A 109
THR A  77
VAL A  73
None
0.78A 2cbrA-2bepA:
undetectable
2cbrA-2bepA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfm THERMOSTABLE DNA
LIGASE


(Pyrococcus
furiosus)
PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C)
6 VAL A  33
LEU A  30
VAL A  26
THR A 164
VAL A 166
LEU A 154
None
1.34A 2cbrA-2cfmA:
undetectable
2cbrA-2cfmA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cuk GLYCERATE
DEHYDROGENASE/GLYOXY
LATE REDUCTASE


(Thermus
thermophilus)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
5 LEU A 225
VAL A 197
VAL A 150
GLY A 231
LEU A  98
None
1.17A 2cbrA-2cukA:
undetectable
2cbrA-2cukA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e8g HYPOTHETICAL PROTEIN
PH0536


(Pyrococcus
horikoshii)
PF01588
(tRNA_bind)
5 LEU A 202
VAL A 184
THR A 158
VAL A 169
GLY A 207
None
1.17A 2cbrA-2e8gA:
undetectable
2cbrA-2e8gA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk9 PHOSPHATIDYLINOSITOL
-4-PHOSPHATE
5-KINASE, TYPE II,
GAMMA


(Homo sapiens)
PF01504
(PIP5K)
5 PHE A 100
LEU A  62
THR A 127
GLY A 187
LEU A  47
None
1.06A 2cbrA-2gk9A:
undetectable
2cbrA-2gk9A:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmh ELECTRON TRANSFER
FLAVOPROTEIN-UBIQUIN
ONE OXIDOREDUCTASE


(Sus scrofa)
PF05187
(ETF_QO)
PF13450
(NAD_binding_8)
5 LEU A 333
THR A 369
GLY A 336
LEU A 344
TYR A 402
FAD  A 611 ( 4.0A)
None
None
None
None
0.99A 2cbrA-2gmhA:
undetectable
2cbrA-2gmhA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2go4 UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE


(Aquifex
aeolicus)
PF03331
(LpxC)
5 VAL A 138
LEU A 271
VAL A 272
THR A  60
GLY A 263
None
1.11A 2cbrA-2go4A:
undetectable
2cbrA-2go4A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivp O-SIALOGLYCOPROTEIN
ENDOPEPTIDASE


(Pyrococcus
abyssi)
PF00814
(Peptidase_M22)
5 LEU A 126
VAL A 248
THR A 243
VAL A 240
GLY A 147
None
0.80A 2cbrA-2ivpA:
undetectable
2cbrA-2ivpA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ph0 UNCHARACTERIZED
PROTEIN


(Pectobacterium
carotovorum)
PF06228
(ChuX_HutX)
5 PHE A 137
VAL A  32
ARG A 113
GLY A  15
LEU A 146
None
1.18A 2cbrA-2ph0A:
undetectable
2cbrA-2ph0A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2psb YERB PROTEIN

(Bacillus
subtilis)
PF11258
(DUF3048)
PF17479
(DUF3048_C)
5 VAL A 280
LEU A 286
THR A 293
GLY A 257
LEU A  92
None
1.18A 2cbrA-2psbA:
undetectable
2cbrA-2psbA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qb6 EXOPOLYPHOSPHATASE

(Saccharomyces
cerevisiae)
PF01368
(DHH)
PF02833
(DHHA2)
5 VAL A 345
LEU A 348
VAL A 352
THR A 324
VAL A 384
None
1.18A 2cbrA-2qb6A:
undetectable
2cbrA-2qb6A:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4


(Saccharopolyspora
erythraea)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
5 LEU A 273
VAL A 132
GLY A 227
LEU A  96
ARG A  41
None
0.97A 2cbrA-2qo3A:
undetectable
2cbrA-2qo3A:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vre DELTA(3,5)-DELTA(2,4
)-DIENOYL-COA
ISOMERASE


(Homo sapiens)
PF00378
(ECH_1)
5 VAL A 189
LEU A 186
VAL A 150
GLY A 215
LEU A 234
None
None
None
CL  A1290 ( 3.7A)
None
1.15A 2cbrA-2vreA:
undetectable
2cbrA-2vreA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT


(Escherichia
coli)
PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C)
5 LEU A 408
THR A 362
VAL A 392
GLY A 204
LEU A 169
FAD  A 601 (-4.0A)
None
None
None
None
1.08A 2cbrA-2wu5A:
undetectable
2cbrA-2wu5A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d2l SAM-DEPENDENT
METHYLTRANSFERASE


(Exiguobacterium
sibiricum)
PF13649
(Methyltransf_25)
5 LEU A  27
VAL A  23
THR A  57
GLY A  33
LEU A 125
None
1.08A 2cbrA-3d2lA:
undetectable
2cbrA-3d2lA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC


(Arabidopsis
thaliana)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
5 VAL A 112
LEU A 107
VAL A 252
GLY A 162
TYR A 276
None
None
None
None
NHE  A 696 (-4.7A)
1.18A 2cbrA-3e9yA:
undetectable
2cbrA-3e9yA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f92 UBIQUITIN-CONJUGATIN
G ENZYME E2 K


(Homo sapiens)
PF00179
(UQ_con)
PF00627
(UBA)
5 VAL A  16
LEU A 106
VAL A 109
THR A  77
VAL A  73
None
0.80A 2cbrA-3f92A:
undetectable
2cbrA-3f92A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fd0 PUTATIVE
CYSTATHIONINE
BETA-LYASE INVOLVED
IN ALUMINUM
RESISTANCE


(Listeria
innocua)
PF06838
(Met_gamma_lyase)
5 PHE A  71
VAL A  78
LEU A  63
VAL A  66
GLY A 229
None
None
None
None
LLP  A 226 ( 3.7A)
1.10A 2cbrA-3fd0A:
undetectable
2cbrA-3fd0A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3few COLICIN S4

(Escherichia
coli)
PF01024
(Colicin)
5 VAL X 405
VAL X 444
VAL X 306
GLY X 394
LEU X 458
None
1.17A 2cbrA-3fewX:
undetectable
2cbrA-3fewX:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g68 PUTATIVE
PHOSPHOSUGAR
ISOMERASE


(Clostridioides
difficile)
PF01380
(SIS)
5 PHE A 311
VAL A  51
VAL A 132
GLY A 157
LEU A 180
None
1.11A 2cbrA-3g68A:
undetectable
2cbrA-3g68A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gq2 GENERAL VESICULAR
TRANSPORT FACTOR
P115


(Bos taurus)
PF04869
(Uso1_p115_head)
5 VAL A 373
VAL A 366
THR A 406
GLY A 427
LEU A 448
None
1.15A 2cbrA-3gq2A:
undetectable
2cbrA-3gq2A:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyk 27KDA OUTER MEMBRANE
PROTEIN


(Ruegeria
pomeroyi)
PF13462
(Thioredoxin_4)
5 PHE A   6
LEU A  53
VAL A  51
VAL A 165
ARG A   2
None
1.02A 2cbrA-3gykA:
undetectable
2cbrA-3gykA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvy CYSTATHIONINE
BETA-LYASE FAMILY
PROTEIN, YNBB
B.SUBTILIS ORTHOLOG


(Clostridium
acetobutylicum)
PF06838
(Met_gamma_lyase)
5 PHE A  86
VAL A  93
LEU A  78
VAL A  81
GLY A 246
None
None
None
None
LLP  A 243 ( 4.0A)
1.04A 2cbrA-3hvyA:
undetectable
2cbrA-3hvyA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i16 ALUMINUM RESISTANCE
PROTEIN


(Clostridium
novyi)
PF06838
(Met_gamma_lyase)
5 PHE A  85
VAL A  92
LEU A  77
VAL A  80
GLY A 246
None
1.04A 2cbrA-3i16A:
undetectable
2cbrA-3i16A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ij3 CYTOSOL
AMINOPEPTIDASE


(Coxiella
burnetii)
PF00883
(Peptidase_M17)
5 LEU A 411
VAL A 323
GLY A 225
LEU A 453
TYR A 457
None
1.04A 2cbrA-3ij3A:
undetectable
2cbrA-3ij3A:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ite SIDN SIDEROPHORE
SYNTHETASE


(Epichloe
festucae)
PF00501
(AMP-binding)
5 LEU A 225
VAL A 268
GLY A 250
LEU A  56
TYR A  53
None
1.13A 2cbrA-3iteA:
undetectable
2cbrA-3iteA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jzl PUTATIVE
CYSTATHIONINE
BETA-LYASE INVOLVED
IN ALUMINUM
RESISTANCE


(Listeria
monocytogenes)
PF06838
(Met_gamma_lyase)
5 PHE A  71
VAL A  78
LEU A  63
VAL A  66
GLY A 229
None
None
None
None
LLP  A 226 ( 3.6A)
1.07A 2cbrA-3jzlA:
undetectable
2cbrA-3jzlA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7f E3 UBIQUITIN-PROTEIN
LIGASE NEDD4


(Mus musculus)
PF00168
(C2)
5 PHE B 178
LEU B 188
THR B 161
VAL B 144
ARG B 145
None
1.09A 2cbrA-3m7fB:
undetectable
2cbrA-3m7fB:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n07 3-DEOXY-D-MANNO-OCTU
LOSONATE 8-PHOSPHATE
PHOSPHATASE


(Vibrio cholerae)
PF08282
(Hydrolase_3)
5 VAL A 163
VAL A  30
VAL A  80
ARG A  83
GLY A  56
None
1.13A 2cbrA-3n07A:
undetectable
2cbrA-3n07A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r08 MOUSE ANTI-MOUSE
CD3EPSILON ANTIBODY
2C11 LIGHT CHAIN


(Cricetulus
migratorius)
PF07654
(C1-set)
PF07686
(V-set)
5 VAL L 163
LEU L 175
VAL L 136
THR L 200
ARG L 108
None
1.01A 2cbrA-3r08L:
undetectable
2cbrA-3r08L:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT L


(Escherichia
coli)
no annotation 5 LEU L 132
VAL L 128
VAL L  92
GLY L  83
LEU L 323
None
1.06A 2cbrA-3rkoL:
undetectable
2cbrA-3rkoL:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3she MAP KINASE-ACTIVATED
PROTEIN KINASE 3


(Homo sapiens)
PF00069
(Pkinase)
5 LEU A 115
VAL A 103
VAL A  85
GLY A  56
LEU A 173
None
1.05A 2cbrA-3sheA:
undetectable
2cbrA-3sheA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3shu TIGHT JUNCTION
PROTEIN ZO-1


(Homo sapiens)
PF00595
(PDZ)
5 VAL A  35
LEU A  20
VAL A  18
VAL A  81
GLY A  45
None
1.03A 2cbrA-3shuA:
undetectable
2cbrA-3shuA:
27.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1k POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL


(Homo sapiens)
PF00013
(KH_1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase)
5 VAL A 472
LEU A 425
THR A 550
THR A 555
GLY A 490
None
1.05A 2cbrA-3u1kA:
undetectable
2cbrA-3u1kA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uif SULFONATE ABC
TRANSPORTER,
PERIPLASMIC
SULFONATE-BINDING
PROTEIN SSUA


(Methylobacillus
flagellatus)
PF09084
(NMT1)
5 VAL A 251
LEU A 248
VAL A 244
VAL A 114
GLY A 118
None
None
None
None
GOL  A 503 ( 3.8A)
0.97A 2cbrA-3uifA:
undetectable
2cbrA-3uifA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uuf LIP1, SECRETORY
LIPASE (FAMILY 3)


(Malassezia
globosa)
PF01764
(Lipase_3)
5 VAL A  84
VAL A 153
VAL A 165
GLY A 169
TYR A 128
None
1.12A 2cbrA-3uufA:
undetectable
2cbrA-3uufA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va7 KLLA0E08119P

(Kluyveromyces
lactis)
PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
5 PHE A1374
VAL A1363
LEU A1360
GLY A1294
TYR A1275
None
None
None
BTI  A1901 ( 3.9A)
None
1.17A 2cbrA-3va7A:
undetectable
2cbrA-3va7A:
8.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wbg FATTY ACID-BINDING
PROTEIN, HEART


(Homo sapiens)
PF00061
(Lipocalin)
6 PHE A  16
VAL A  32
THR A  53
LEU A 115
ARG A 126
TYR A 128
2AN  A 201 ( 4.9A)
None
2AN  A 201 ( 4.0A)
None
2AN  A 201 ( 4.9A)
None
0.87A 2cbrA-3wbgA:
19.3
2cbrA-3wbgA:
39.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wgo MESO-DIAMINOPIMELATE
DEHYDROGENASE


(Clostridium
tetani)
PF16654
(DAPDH_C)
5 VAL A 305
LEU A 130
THR A 146
VAL A 253
GLY A 122
None
1.08A 2cbrA-3wgoA:
undetectable
2cbrA-3wgoA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwe OXIDIZED POLYVINYL
ALCOHOL HYDROLASE


(Pseudomonas sp.
VM15C)
no annotation 5 VAL A  28
VAL A 152
THR A  70
VAL A  61
GLY A  31
None
1.14A 2cbrA-3wweA:
undetectable
2cbrA-3wweA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zlb PHOSPHOGLYCERATE
KINASE


(Streptococcus
pneumoniae)
PF00162
(PGK)
5 VAL A 211
LEU A 215
VAL A 222
THR A 335
GLY A 353
None
1.17A 2cbrA-3zlbA:
undetectable
2cbrA-3zlbA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a73 L-LACTATE
DEHYDROGENASE


(Thermus
thermophilus)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
5 VAL A 298
LEU A 293
THR A 169
GLY A 162
LEU A 315
None
1.13A 2cbrA-4a73A:
undetectable
2cbrA-4a73A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4atw ALPHA-L-ARABINOFURAN
OSIDASE DOMAIN
PROTEIN


(Thermotoga
maritima)
PF06964
(Alpha-L-AF_C)
5 VAL A 260
LEU A 263
VAL A 267
THR A 195
GLY A 211
None
1.13A 2cbrA-4atwA:
undetectable
2cbrA-4atwA:
13.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4azn FATTY ACID-BINDING
PROTEIN, EPIDERMAL


(Mus musculus)
PF00061
(Lipocalin)
6 PHE A  19
VAL A  28
LEU A  32
THR A  56
ARG A 129
TYR A 131
None
0.84A 2cbrA-4aznA:
18.8
2cbrA-4aznA:
34.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4azn FATTY ACID-BINDING
PROTEIN, EPIDERMAL


(Mus musculus)
PF00061
(Lipocalin)
6 PHE A  19
VAL A  28
LEU A  32
THR A  56
GLY A  80
TYR A 131
None
0.88A 2cbrA-4aznA:
18.8
2cbrA-4aznA:
34.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4azp FATTY ACID-BINDING
PROTEIN, EPIDERMAL


(Mus musculus)
PF00061
(Lipocalin)
5 PHE A  19
THR A  56
VAL A  60
ARG A 129
TYR A 131
None
A9M  A1136 ( 4.3A)
A9M  A1136 (-4.8A)
A9M  A1136 (-4.3A)
A9M  A1136 (-4.8A)
0.71A 2cbrA-4azpA:
19.7
2cbrA-4azpA:
33.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b92 DIHYDROPYRIMIDINASE-
RELATED PROTEIN 5


(Homo sapiens)
PF01979
(Amidohydro_1)
5 PHE A 373
VAL A 403
VAL A 435
THR A 273
LEU A 314
None
1.16A 2cbrA-4b92A:
undetectable
2cbrA-4b92A:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bpy SCO PROTEIN

(Streptomyces
lividans)
PF02630
(SCO1-SenC)
5 PHE A 183
VAL A 115
THR A 178
GLY A 153
LEU A  47
None
1.12A 2cbrA-4bpyA:
undetectable
2cbrA-4bpyA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c22 L-FUCOSE ISOMERASE

(Streptococcus
pneumoniae)
PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2)
5 VAL A  35
VAL A 153
THR A 539
LEU A 350
ARG A 162
None
1.18A 2cbrA-4c22A:
undetectable
2cbrA-4c22A:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB

(Homo sapiens)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2)
5 LEU A 786
VAL A 748
THR A 793
VAL A 794
GLY A 822
None
1.17A 2cbrA-4cakA:
undetectable
2cbrA-4cakA:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4csi CELLULASE

(Humicola grisea)
PF00840
(Glyco_hydro_7)
5 VAL A  73
THR A 209
GLY A 165
ARG A 108
TYR A 146
PCA  A   1 ( 4.9A)
None
None
None
PEG  A1439 (-3.9A)
1.02A 2cbrA-4csiA:
undetectable
2cbrA-4csiA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dzt AQUALYSIN-1

(Thermus
aquaticus)
PF00082
(Peptidase_S8)
5 LEU A 137
VAL A 141
THR A 175
VAL A 153
GLY A 132
None
None
CA  A 303 (-3.6A)
None
None
1.14A 2cbrA-4dztA:
undetectable
2cbrA-4dztA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4emd 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE


(Mycobacteroides
abscessus)
PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
5 LEU A  24
VAL A  42
THR A 169
VAL A 170
GLY A 300
None
1.12A 2cbrA-4emdA:
undetectable
2cbrA-4emdA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i99 CHROMOSOME PARTITION
PROTEIN SMC


(Pyrococcus
furiosus)
PF02463
(SMC_N)
5 VAL A  82
VAL A  20
THR A  29
VAL A1152
GLY A  43
None
1.07A 2cbrA-4i99A:
undetectable
2cbrA-4i99A:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ivi CARBOXYLESTERASE

(uncultured
bacterium)
PF00144
(Beta-lactamase)
5 VAL A 232
LEU A 119
VAL A 114
GLY A 226
LEU A 246
None
1.06A 2cbrA-4iviA:
undetectable
2cbrA-4iviA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k5r OXYGENASE

(Streptomyces
argillaceus)
PF01494
(FAD_binding_3)
5 VAL A 478
LEU A 439
VAL A 463
VAL A 427
GLY A 415
None
0.97A 2cbrA-4k5rA:
undetectable
2cbrA-4k5rA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfu EDS1

(Arabidopsis
thaliana)
PF01764
(Lipase_3)
5 LEU A  93
THR A 193
VAL A  85
GLY A 126
LEU A 204
None
1.17A 2cbrA-4nfuA:
undetectable
2cbrA-4nfuA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ou2 2-AMINOMUCONATE
6-SEMIALDEHYDE
DEHYDROGENASE


(Pseudomonas
fluorescens)
PF00171
(Aldedh)
5 LEU A 183
VAL A 179
THR A 243
VAL A 164
GLY A 160
None
1.12A 2cbrA-4ou2A:
undetectable
2cbrA-4ou2A:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psn SSDNA BINDING
PROTEIN


(Aeropyrum
pernix)
PF10015
(DUF2258)
5 VAL A 126
THR A 129
VAL A 217
GLY A 161
LEU A 153
None
1.00A 2cbrA-4psnA:
2.3
2cbrA-4psnA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0s PROTEIN TYROSINE
PHOSPHATASE TPBA


(Pseudomonas
aeruginosa)
PF03162
(Y_phosphatase2)
5 LEU A 129
THR A  34
VAL A  43
GLY A 135
ARG A 147
None
None
None
PO4  A 301 ( 4.5A)
None
1.18A 2cbrA-4r0sA:
undetectable
2cbrA-4r0sA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rkk LAFORIN

(Homo sapiens)
PF00686
(CBM_20)
PF00782
(DSPc)
5 VAL A 292
LEU A 296
VAL A 303
THR A 238
GLY A 279
None
1.13A 2cbrA-4rkkA:
undetectable
2cbrA-4rkkA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rlz CAPSID PROTEIN

(Norwalk virus)
PF00915
(Calici_coat)
PF08435
(Calici_coat_C)
5 PHE A 326
VAL A 435
THR A 273
LEU A 402
TYR A 405
None
1.18A 2cbrA-4rlzA:
undetectable
2cbrA-4rlzA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0t RIBONUCLEASE J

(Streptomyces
coelicolor)
PF00753
(Lactamase_B)
PF07521
(RMMBL)
5 VAL A 149
VAL A 159
THR A  35
VAL A  46
LEU A 405
None
1.17A 2cbrA-5a0tA:
undetectable
2cbrA-5a0tA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5auo ATPASE INVOLVED IN
CHROMOSOME
PARTITIONING,
PARA/MIND FAMILY,
MRP HOMOLOG


(Thermococcus
kodakarensis)
PF10609
(ParA)
5 VAL B  43
LEU B  40
VAL B  36
VAL B 185
GLY B 246
None
0.96A 2cbrA-5auoB:
undetectable
2cbrA-5auoB:
18.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5b29 FATTY ACID-BINDING
PROTEIN, HEART


(Homo sapiens)
PF00061
(Lipocalin)
5 VAL A  25
THR A  53
LEU A 115
ARG A 126
TYR A 128
None
PLM  A 200 ( 4.2A)
None
PLM  A 200 (-3.7A)
PLM  A 200 (-4.8A)
0.80A 2cbrA-5b29A:
19.3
2cbrA-5b29A:
40.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5bvt EPIDERMAL FATTY
ACID-BINDING PROTEIN


(Pygoscelis
papua)
PF00061
(Lipocalin)
5 PHE A  19
THR A  56
GLY A  80
ARG A 130
TYR A 132
PAM  A 201 ( 4.9A)
None
None
PAM  A 201 ( 4.6A)
None
0.86A 2cbrA-5bvtA:
19.1
2cbrA-5bvtA:
38.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cee NAD-DEPENDENT MALIC
ENZYME


(Aster yellows
witches'-broom
phytoplasma)
PF00390
(malic)
PF03949
(Malic_M)
5 VAL A 266
LEU A 247
VAL A 250
VAL A 212
GLY A 259
None
1.16A 2cbrA-5ceeA:
undetectable
2cbrA-5ceeA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dfl UBIQUITIN-CONJUGATIN
G ENZYME E2 K


(Homo sapiens)
PF00179
(UQ_con)
PF00627
(UBA)
5 VAL A  16
LEU A 106
VAL A 109
THR A  77
VAL A  73
None
None
None
None
GOL  A 301 (-4.4A)
0.77A 2cbrA-5dflA:
undetectable
2cbrA-5dflA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9a BETA-GALACTOSIDASE

(Rahnella sp. R3)
PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C)
5 PHE A 606
VAL A 448
VAL A 434
THR A 492
LEU A 543
None
1.05A 2cbrA-5e9aA:
undetectable
2cbrA-5e9aA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f4j PROTRUDING DOMAIN OF
GII.17 NOROVIRUS
CAPSID


(Norwalk virus)
PF08435
(Calici_coat_C)
5 PHE A 329
VAL A 438
THR A 275
LEU A 405
TYR A 408
None
1.17A 2cbrA-5f4jA:
undetectable
2cbrA-5f4jA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz1 MESO-DIAMINOPIMELATE
D-DEHYDROGENASE


(Ureibacillus
thermosphaericus)
PF01113
(DapB_N)
PF16654
(DAPDH_C)
5 VAL A 305
LEU A 130
THR A 146
VAL A 253
GLY A 122
None
1.02A 2cbrA-5gz1A:
undetectable
2cbrA-5gz1A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i35 ATYPICAL KINASE
ADCK3, MITOCHONDRIAL


(Homo sapiens)
PF03109
(ABC1)
5 VAL A 300
LEU A 267
VAL A 270
GLY A 278
TYR A 408
None
1.17A 2cbrA-5i35A:
undetectable
2cbrA-5i35A:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis)
PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
5 PHE A1374
VAL A1363
LEU A1360
GLY A1294
TYR A1275
None
1.18A 2cbrA-5i8iA:
undetectable
2cbrA-5i8iA:
5.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nhs BIFUNCTIONAL PROTEIN
FOLD


(Xanthomonas
albilineans)
no annotation 5 VAL A 238
LEU A 217
VAL A 174
GLY A 229
LEU A 246
None
1.14A 2cbrA-5nhsA:
undetectable
2cbrA-5nhsA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1


(Homo sapiens)
PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9)
5 PHE A4145
VAL A4055
THR A4039
ARG A4123
GLY A4032
None
1.07A 2cbrA-5nugA:
undetectable
2cbrA-5nugA:
2.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0d PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE


(Mycobacteroides
abscessus)
PF01467
(CTP_transf_like)
5 LEU A 152
VAL A 148
VAL A  13
ARG A  50
GLY A  43
None
1.16A 2cbrA-5o0dA:
undetectable
2cbrA-5o0dA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tzy FREE FATTY ACID
RECEPTOR
1,ENDOLYSIN,FREE
FATTY ACID RECEPTOR
1


(Escherichia
virus T4;
Homo sapiens)
PF00001
(7tm_1)
PF00959
(Phage_lysozyme)
5 VAL A 134
LEU A 190
GLY A  93
LEU A  59
TYR A  12
7OS  A2403 (-4.6A)
7OS  A2403 (-4.3A)
None
None
None
1.14A 2cbrA-5tzyA:
undetectable
2cbrA-5tzyA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5udb DNA REPLICATION
LICENSING FACTOR
MCM2


(Saccharomyces
cerevisiae)
PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB)
5 LEU 2 519
VAL 2 515
VAL 2 539
GLY 2 522
LEU 2 834
None
1.15A 2cbrA-5udb2:
undetectable
2cbrA-5udb2:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xau LAMININ SUBUNIT
ALPHA-5


(Homo sapiens)
PF02210
(Laminin_G_2)
PF06009
(Laminin_II)
5 PHE A3258
VAL A3288
LEU A3133
VAL A3265
GLY A3291
None
1.09A 2cbrA-5xauA:
undetectable
2cbrA-5xauA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xei CHROMOSOME PARTITION
PROTEIN SMC


(Pyrococcus
yayanosii)
PF02463
(SMC_N)
5 VAL A  82
VAL A  20
THR A  29
VAL A1152
GLY A  43
None
1.05A 2cbrA-5xeiA:
undetectable
2cbrA-5xeiA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c66 CRISPR-ASSOCIATED
PROTEIN, CAS5E
FAMILY
CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY


(Thermobifida
fusca)
no annotation 5 VAL M  71
LEU M  70
VAL M  68
GLY A 469
LEU A 338
None
1.18A 2cbrA-6c66M:
undetectable
2cbrA-6c66M:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6db7 HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 1334 FAB
HEAVY CHAIN


(Homo sapiens)
no annotation 5 VAL H  67
LEU H  82
VAL H  18
VAL H 109
LEU H   4
None
1.17A 2cbrA-6db7H:
undetectable
2cbrA-6db7H:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eqc SCFV OF 9C12
ANTIBODY


(Mus musculus)
no annotation 5 VAL D 197
LEU D 212
VAL D 148
THR D 241
VAL D 243
None
1.07A 2cbrA-6eqcD:
undetectable
2cbrA-6eqcD:
18.94