SIMILAR PATTERNS OF AMINO ACIDS FOR 2C8A_D_NCAD1247

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aye PROCARBOXYPEPTIDASE
A2

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		5 GLY A 278
SER A 199
SER A 197
PHE A 279
GLU A 270
 None
None
None
None
ZN  A 400 (-4.3A)
 1.28A 2c8aD-1ayeA:
undetectable		 2c8aD-1ayeA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1db3 GDP-MANNOSE
4,6-DEHYDRATASE

(Escherichia
coli) 		PF16363
(GDP_Man_Dehyd) 		4 GLY A  86
SER A  89
ARG A  33
GLU A 134
 None
 1.03A 2c8aD-1db3A:
undetectable		 2c8aD-1db3A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dtd CARBOXYPEPTIDASE A2

(Homo sapiens) 		PF00246
(Peptidase_M14) 		5 GLY A 634
SER A 555
SER A 553
PHE A 635
GLU A 626
 None
None
None
None
GLU  A 300 (-4.2A)
 1.30A 2c8aD-1dtdA:
undetectable		 2c8aD-1dtdA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ewi REPLICATION PROTEIN
A

(Homo sapiens) 		PF04057
(Rep-A_N) 		4 GLY A 109
SER A 104
SER A  72
GLU A  69
 None
 1.06A 2c8aD-1ewiA:
undetectable		 2c8aD-1ewiA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ft5 CYTOCHROME C554

(Nitrosomonas
europaea) 		PF13435
(Cytochrome_C554) 		4 ARG A   8
GLY A  85
SER A  90
GLU A  89
 PO4  A 218 (-3.8A)
None
HEM  A 216 (-3.9A)
None
 1.02A 2c8aD-1ft5A:
undetectable		 2c8aD-1ft5A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gd7 CSAA PROTEIN

(Thermus
thermophilus) 		PF01588
(tRNA_bind) 		4 ARG A  73
GLY A  76
PHE A  77
GLU A  80
 None
 0.90A 2c8aD-1gd7A:
undetectable		 2c8aD-1gd7A:
19.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gze MONO-ADP-RIBOSYLTRAN
SFERASE C3

(Clostridium
botulinum) 		PF03496
(ADPrib_exo_Tox) 		4 ARG A 128
GLY A 129
SER A 174
GLU A 214
 None
 0.50A 2c8aD-1gzeA:
33.6		 2c8aD-1gzeA:
99.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hpl LIPASE

(Equus caballus) 		PF00151
(Lipase)
PF01477
(PLAT) 		4 GLY A 282
SER A 300
PHE A 325
GLU A 302
 None
 0.98A 2c8aD-1hplA:
undetectable		 2c8aD-1hplA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hqz ACTIN-BINDING
PROTEIN

(Saccharomyces
cerevisiae) 		PF00241
(Cofilin_ADF) 		4 GLY 1  67
SER 1  36
SER 1  47
GLU 1  46
 None
 0.97A 2c8aD-1hqz1:
undetectable		 2c8aD-1hqz1:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5x SURVIVAL PROTEIN E

(Pyrobaculum
aerophilum) 		PF01975
(SurE) 		4 GLY A  42
SER A  67
SER A  36
GLU A  35
 None
 0.98A 2c8aD-1l5xA:
undetectable		 2c8aD-1l5xA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lt3 HEAT-LABILE
ENTEROTOXIN

(Escherichia
coli) 		PF01375
(Enterotoxin_a) 		4 ARG A   7
SER A  61
SER A  63
GLU A 112
 None
 0.97A 2c8aD-1lt3A:
undetectable		 2c8aD-1lt3A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ltt HEAT-LABILE
ENTEROTOXIN, SUBUNIT
A

(Escherichia
coli) 		PF01375
(Enterotoxin_a) 		4 ARG A   7
SER A  61
SER A  63
GLU A 112
 None
 0.72A 2c8aD-1lttA:
undetectable		 2c8aD-1lttA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m6d CATHEPSIN F

(Homo sapiens) 		PF00112
(Peptidase_C1) 		4 GLY A  32
SER A  49
SER A  47
GLU A  83
 None
 1.01A 2c8aD-1m6dA:
undetectable		 2c8aD-1m6dA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mkm ICLR TRANSCRIPTIONAL
REGULATOR

(Thermotoga
maritima) 		PF01614
(IclR)
PF09339
(HTH_IclR) 		4 GLY A 206
SER A 241
PHE A 202
GLU A 238
 None
 1.00A 2c8aD-1mkmA:
undetectable		 2c8aD-1mkmA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oyz HYPOTHETICAL PROTEIN
YIBA

(Escherichia
coli) 		PF13646
(HEAT_2) 		4 GLY A  74
SER A 114
PHE A  76
GLU A 113
 None
 1.03A 2c8aD-1oyzA:
undetectable		 2c8aD-1oyzA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qs1 ADP-RIBOSYLTRANSFERA
SE

(Bacillus cereus) 		PF03496
(ADPrib_exo_Tox) 		4 ARG A 349
SER A 386
ARG A 400
GLU A 428
 None
 1.07A 2c8aD-1qs1A:
19.9		 2c8aD-1qs1A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qs2 ADP-RIBOSYLTRANSFERA
SE

(Bacillus cereus) 		PF03496
(ADPrib_exo_Tox) 		4 ARG A 349
SER A 386
PHE A 397
ARG A 400
 NAD  A 500 (-3.7A)
NAD  A 500 ( 3.8A)
NAD  A 500 (-3.5A)
NAD  A 500 (-3.6A)
 0.93A 2c8aD-1qs2A:
20.1		 2c8aD-1qs2A:
23.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r45 MONO-ADP-RIBOSYLTRAN
SFERASE C3

(Clostridium
phage c-st) 		PF03496
(ADPrib_exo_Tox) 		4 GLY A 129
SER A 174
ARG A 185
GLU A 213
 None
 0.97A 2c8aD-1r45A:
30.3		 2c8aD-1r45A:
63.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s5f CHOLERA ENTEROTOXIN,
A CHAIN

(Vibrio cholerae) 		PF01375
(Enterotoxin_a) 		4 ARG A   7
SER A  61
SER A  63
GLU A 112
 None
 0.99A 2c8aD-1s5fA:
undetectable		 2c8aD-1s5fA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tuf DIAMINOPIMELATE
DECARBOXYLASE

(Methanocaldococcus
jannaschii) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 GLY A  32
SER A 421
SER A  50
GLU A  51
 None
 1.10A 2c8aD-1tufA:
undetectable		 2c8aD-1tufA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6r CREATINE KINASE, M
CHAIN

(Oryctolagus
cuniculus) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		4 ARG A 131
GLY A 289
ARG A 340
GLU A 231
 ADP  A1801 (-3.8A)
None
None
None
 1.06A 2c8aD-1u6rA:
undetectable		 2c8aD-1u6rA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlj NADH-DEPENDENT
BUTANOL
DEHYDROGENASE

(Thermotoga
maritima) 		PF00465
(Fe-ADH) 		4 ARG A 377
GLY A 263
SER A 208
GLU A   2
 None
 1.01A 2c8aD-1vljA:
undetectable		 2c8aD-1vljA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vp6 CYCLIC-NUCLEOTIDE
BINDING DOMAIN OF
MESORHIZOBIUM LOTI
CNG POTASSIUM
CHANNEL

(Mesorhizobium
loti) 		PF00027
(cNMP_binding) 		4 GLY A 259
SER A 279
SER A 281
GLU A 289
 BR  A 360 ( 3.7A)
None
None
None
 0.90A 2c8aD-1vp6A:
undetectable		 2c8aD-1vp6A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zye THIOREDOXIN-DEPENDEN
T PEROXIDE REDUCTASE

(Bos taurus) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		4 GLY A 124
SER A  72
PHE A  37
ARG A 146
 None
 1.07A 2c8aD-1zyeA:
undetectable		 2c8aD-1zyeA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aif RIBOSOMAL PROTEIN
L7A

(Cryptosporidium
parvum) 		PF01248
(Ribosomal_L7Ae) 		4 GLY A 114
SER A 111
SER A 118
GLU A  57
 None
 0.93A 2c8aD-2aifA:
undetectable		 2c8aD-2aifA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1

(Homo sapiens) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		4 GLY A 777
SER A 674
ARG A 536
GLU A 773
 None
 1.09A 2c8aD-2b3xA:
undetectable		 2c8aD-2b3xA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2boa CARBOXYPEPTIDASE A4

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		5 GLY A1278
SER A1199
SER A1197
PHE A1279
GLU A1270
 None
 1.30A 2c8aD-2boaA:
undetectable		 2c8aD-2boaA:
20.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2bov MONO-ADP-RIBOSYLTRAN
SFERASE C3

(Clostridium
botulinum) 		PF03496
(ADPrib_exo_Tox) 		5 ARG B1128
GLY B1129
SER B1174
ARG B1186
GLU B1214
 None
 0.93A 2c8aD-2bovB:
32.7		 2c8aD-2bovB:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0h MANNAN
ENDO-1,4-BETA-MANNOS
IDASE

(Mytilus edulis) 		PF00150
(Cellulase) 		4 GLY A 316
SER A 319
SER A 321
GLU A 320
 None
 0.98A 2c8aD-2c0hA:
undetectable		 2c8aD-2c0hA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ezv TYPE II RESTRICTION
ENZYME SFII

(Streptomyces
fimbriatus) 		PF11487
(RestrictionSfiI) 		4 GLY A 207
SER A 210
ARG A 220
GLU A 215
 None
 1.04A 2c8aD-2ezvA:
undetectable		 2c8aD-2ezvA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fem CYTIDYLATE KINASE

(Escherichia
coli) 		PF02224
(Cytidylate_kin) 		4 GLY A  15
SER A 150
ARG A 157
GLU A 152
 None
 1.08A 2c8aD-2femA:
undetectable		 2c8aD-2femA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal disease
virus) 		PF04197
(Birna_RdRp) 		4 SER A 687
SER A 689
ARG A 627
GLU A 688
 None
 1.00A 2c8aD-2pggA:
undetectable		 2c8aD-2pggA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uux TRYPTASE INHIBITOR

(Rhipicephalus
appendiculatus) 		no annotation 4 ARG A  44
GLY A  61
SER A  64
GLU A  68
 None
 0.82A 2c8aD-2uuxA:
undetectable		 2c8aD-2uuxA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w20 SIALIDASE A

(Streptococcus
pneumoniae) 		PF13088
(BNR_2) 		4 ARG A 334
GLY A 773
SER A 332
GLU A 331
 None
 1.02A 2c8aD-2w20A:
undetectable		 2c8aD-2w20A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT

(Homo sapiens) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC) 		4 GLY A 735
SER A 707
SER A 705
GLU A 431
 None
 0.98A 2c8aD-2wghA:
undetectable		 2c8aD-2wghA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wn4 ADP-RIBOSYLTRANSFERA
SE ENZYMATIC
COMPONENT

(Clostridioides
difficile) 		PF03496
(ADPrib_exo_Tox) 		5 ARG A 302
SER A 345
PHE A 356
ARG A 359
GLU A 387
 None
 1.12A 2c8aD-2wn4A:
23.4		 2c8aD-2wn4A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xt0 HALOALKANE
DEHALOGENASE

(Plesiocystis
pacifica) 		PF00561
(Abhydrolase_1) 		4 ARG A 103
GLY A  99
SER A 104
PHE A 100
 None
 1.09A 2c8aD-2xt0A:
undetectable		 2c8aD-2xt0A:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xtz GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-1
SUBUNIT

(Arabidopsis
thaliana) 		PF00503
(G-alpha) 		4 GLY A 221
SER A  49
ARG A 226
GLU A 247
 GSP  A1382 (-3.4A)
GSP  A1382 (-3.4A)
None
None
 1.08A 2c8aD-2xtzA:
undetectable		 2c8aD-2xtzA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yew E2 ENVELOPE
GLYCOPROTEIN

(Barmah Forest
virus) 		PF00943
(Alpha_E2_glycop) 		4 ARG C  79
GLY C  54
SER C  80
GLU C  78
 None
 1.11A 2c8aD-2yewC:
undetectable		 2c8aD-2yewC:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bex TYPE III
PANTOTHENATE KINASE

(Thermotoga
maritima) 		PF03309
(Pan_kinase) 		4 GLY A  56
SER A  81
SER A  74
GLU A  71
 None
 0.97A 2c8aD-3bexA:
undetectable		 2c8aD-3bexA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3buz IOTA TOXIN COMPONENT
IA

(Clostridium
perfringens) 		PF03496
(ADPrib_exo_Tox) 		4 ARG A 295
SER A 338
ARG A 352
GLU A 380
 TAD  A 500 (-3.2A)
TAD  A 500 (-3.2A)
TAD  A 500 (-2.7A)
TAD  A 500 (-2.6A)
 0.67A 2c8aD-3buzA:
18.4		 2c8aD-3buzA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bvp TP901-1 INTEGRASE

(Lactococcus
phage TP901-1) 		PF00239
(Resolvase) 		4 GLY A 119
SER A 107
PHE A 122
GLU A 110
 None
 0.98A 2c8aD-3bvpA:
undetectable		 2c8aD-3bvpA:
25.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3bw8 MONO-ADP-RIBOSYLTRAN
SFERASE C3

(Hathewaya
limosa) 		PF03496
(ADPrib_exo_Tox) 		5 ARG A  88
GLY A  89
SER A 134
ARG A 146
GLU A 174
 None
 0.38A 2c8aD-3bw8A:
31.3		 2c8aD-3bw8A:
59.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3bw8 MONO-ADP-RIBOSYLTRAN
SFERASE C3

(Hathewaya
limosa) 		PF03496
(ADPrib_exo_Tox) 		4 GLY A  89
SER A 134
SER A 136
GLU A 174
 None
 0.91A 2c8aD-3bw8A:
31.3		 2c8aD-3bw8A:
59.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e38 TWO-DOMAIN PROTEIN
CONTAINING PREDICTED
PHP-LIKE
METAL-DEPENDENT
PHOSPHOESTERASE

(Bacteroides
vulgatus) 		PF16392
(DUF5001) 		4 ARG A 330
GLY A 332
PHE A 333
GLU A 282
 None
 1.07A 2c8aD-3e38A:
undetectable		 2c8aD-3e38A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e58 PUTATIVE
BETA-PHOSPHOGLUCOMUT
ASE

(Streptococcus
thermophilus) 		PF13419
(HAD_2) 		4 GLY A  46
SER A  41
SER A 168
GLU A 169
 None
 0.97A 2c8aD-3e58A:
undetectable		 2c8aD-3e58A:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fii BOTULINUM NEUROTOXIN
TYPE F

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		4 ARG A  49
GLY A 159
SER A 196
GLU A 198
 None
 0.99A 2c8aD-3fiiA:
undetectable		 2c8aD-3fiiA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpx 2-ISOPROPYLMALATE
SYNTHASE

(Mycobacterium
tuberculosis) 		PF00682
(HMGL-like) 		4 GLY A 113
SER A 116
PHE A 114
ARG A  80
 None
 1.08A 2c8aD-3hpxA:
undetectable		 2c8aD-3hpxA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nnk UREIDOGLYCINE-GLYOXY
LATE
AMINOTRANSFERASE

(Klebsiella
pneumoniae) 		PF00266
(Aminotran_5) 		4 GLY A 326
SER A 150
SER A 353
PHE A 314
 None
 0.94A 2c8aD-3nnkA:
undetectable		 2c8aD-3nnkA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ob8 BETA-GALACTOSIDASE

(Kluyveromyces
lactis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N) 		4 ARG A 111
GLY A  37
SER A  34
GLU A  33
 None
 1.06A 2c8aD-3ob8A:
undetectable		 2c8aD-3ob8A:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sju KETO REDUCTASE

(Streptomyces
griseoruber) 		PF00106
(adh_short) 		4 ARG A 118
GLY A 115
SER A  64
GLU A  67
 None
 1.05A 2c8aD-3sjuA:
undetectable		 2c8aD-3sjuA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sm3 SAM-DEPENDENT
METHYLTRANSFERASES

(Methanosarcina
mazei) 		PF08241
(Methyltransf_11) 		4 GLY A 143
SER A 167
PHE A 185
GLU A 164
 None
 0.92A 2c8aD-3sm3A:
undetectable		 2c8aD-3sm3A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t7s PUTATIVE
METHYLTRANSFERASE

(Bacteroides
vulgatus) 		PF13649
(Methyltransf_25) 		4 GLY A  27
SER A 151
SER A 149
GLU A 150
 SAM  A 300 (-4.1A)
None
None
None
 0.95A 2c8aD-3t7sA:
undetectable		 2c8aD-3t7sA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ts0 PROTEIN LIN-28
HOMOLOG A

(Mus musculus) 		PF00098
(zf-CCHC)
PF00313
(CSD) 		4 ARG A  85
GLY A  83
SER A  86
PHE A  84
 G  U   7 ( 3.3A)
None
None
A  U   6 ( 3.3A)
 0.98A 2c8aD-3ts0A:
undetectable		 2c8aD-3ts0A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uhj PROBABLE GLYCEROL
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00465
(Fe-ADH) 		4 GLY A 266
SER A 196
PHE A 269
GLU A 200
 None
 1.04A 2c8aD-3uhjA:
undetectable		 2c8aD-3uhjA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ure ALPHA-LYTIC PROTEASE

(Lysobacter
enzymogenes) 		PF00089
(Trypsin) 		4 GLY A  56
SER A 214
PHE A  94
ARG A  90
 None
 0.96A 2c8aD-3ureA:
undetectable		 2c8aD-3ureA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyv AOX3

(Mus musculus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 GLY A 920
SER A 879
PHE A 919
GLU A 880
 None
NA  A2337 (-2.4A)
None
None
 1.05A 2c8aD-3zyvA:
undetectable		 2c8aD-3zyvA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ag4 EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1
MONOCLONAL ANTIBODY
3E3 HEAVY CHAIN

(Homo sapiens;
Mus musculus) 		PF00754
(F5_F8_type_C)
PF07654
(C1-set)
PF07686
(V-set) 		4 ARG A 341
GLY A 315
SER H  32
SER H  30
 None
 1.06A 2c8aD-4ag4A:
undetectable		 2c8aD-4ag4A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c9g ADP, ATP CARRIER
PROTEIN 2

(Saccharomyces
cerevisiae) 		PF00153
(Mito_carr) 		4 GLY A  89
SER A  85
ARG A 152
GLU A  81
 GLY  A  89 (-0.0A)
SER  A  85 ( 0.0A)
ARG  A 152 ( 0.6A)
GLU  A  81 ( 0.6A)
 0.99A 2c8aD-4c9gA:
undetectable		 2c8aD-4c9gA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fk7 PUTATIVE
ADP-RIBOSYLTRANSFERA
SE CERTHRAX

(Bacillus cereus) 		PF03496
(ADPrib_exo_Tox) 		4 ARG A 341
SER A 387
SER A 389
GLU A 431
 P34  A1001 (-3.6A)
P34  A1001 (-4.0A)
P34  A1001 (-3.1A)
P34  A1001 (-3.9A)
 0.61A 2c8aD-4fk7A:
24.0		 2c8aD-4fk7A:
27.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnq ALPHA-GALACTOSIDASE
AGAB

(Geobacillus
stearothermophilus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		4 SER A 525
PHE A 533
ARG A 203
GLU A 524
 None
 1.10A 2c8aD-4fnqA:
undetectable		 2c8aD-4fnqA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxq PUTATIVE
ADP-RIBOSYLTRANSFERA
SE CERTHRAX

(Bacillus cereus) 		PF03496
(ADPrib_exo_Tox)
PF07737
(ATLF) 		4 ARG A 341
SER A 387
SER A 389
GLU A 431
 CL  A 503 ( 4.1A)
G9L  A 501 (-4.2A)
G9L  A 501 (-3.0A)
G9L  A 501 (-3.7A)
 0.53A 2c8aD-4fxqA:
24.7		 2c8aD-4fxqA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gaa MGC78867 PROTEIN

(Xenopus laevis) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		4 GLY A 265
SER A 288
ARG A 560
GLU A 322
 BES  A 702 (-3.2A)
None
BES  A 702 (-4.0A)
BES  A 702 ( 4.6A)
 1.08A 2c8aD-4gaaA:
undetectable		 2c8aD-4gaaA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0c PHOSPHOLIPASE/CARBOX
YLESTERASE

(Dyadobacter
fermentans) 		PF02230
(Abhydrolase_2) 		4 GLY A 130
SER A 165
SER A 170
GLU A 169
 CIT  A 301 (-3.4A)
None
None
None
 0.83A 2c8aD-4h0cA:
undetectable		 2c8aD-4h0cA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jx0 HYPOTHETICAL PROTEIN

(Bacteroides
fragilis) 		PF08522
(DUF1735) 		4 GLY A 296
SER A 280
SER A 204
ARG A 198
 None
 0.84A 2c8aD-4jx0A:
undetectable		 2c8aD-4jx0A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kxr ESPG5

(Mycobacterium
tuberculosis) 		PF14011
(ESX-1_EspG) 		4 GLY C 196
SER C 185
SER C 189
GLU C 188
 None
 1.10A 2c8aD-4kxrC:
undetectable		 2c8aD-4kxrC:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nq3 CYANURIC ACID
AMIDOHYDROLASE

(Azorhizobium
caulinodans) 		PF09663
(Amido_AtzD_TrzD) 		4 ARG A 188
GLY A 334
SER A 227
SER A  79
 BR8  A 401 (-4.1A)
BR8  A 401 (-3.6A)
BR8  A 401 (-4.8A)
BR8  A 401 (-2.7A)
 1.08A 2c8aD-4nq3A:
undetectable		 2c8aD-4nq3A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4olp GRPU
MICROCOMPARTMENT
SHELL PROTEIN

(Pectobacterium
parmentieri) 		PF00936
(BMC) 		4 ARG A  26
SER A  23
SER A  25
GLU A  24
 None
 0.88A 2c8aD-4olpA:
undetectable		 2c8aD-4olpA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qrl HYPOTHETICAL PROTEIN

(Bacteroides
uniformis) 		PF16585
(Lipocalin_8) 		4 GLY A  75
SER A  92
PHE A  74
GLU A  91
 None
 1.02A 2c8aD-4qrlA:
undetectable		 2c8aD-4qrlA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7v ARRESTIN
DOMAIN-CONTAINING
PROTEIN 3

(Homo sapiens) 		PF00339
(Arrestin_N) 		4 GLY A  53
SER A 133
ARG A  52
GLU A 128
 None
 0.93A 2c8aD-4r7vA:
undetectable		 2c8aD-4r7vA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7v ARRESTIN
DOMAIN-CONTAINING
PROTEIN 3

(Homo sapiens) 		PF00339
(Arrestin_N) 		4 GLY A  53
SER A 133
SER A 126
GLU A 128
 None
 1.04A 2c8aD-4r7vA:
undetectable		 2c8aD-4r7vA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7x ARRESTIN
DOMAIN-CONTAINING
PROTEIN 3

(Homo sapiens) 		PF00339
(Arrestin_N) 		4 GLY A  53
SER A 133
SER A 126
GLU A 128
 None
 0.87A 2c8aD-4r7xA:
undetectable		 2c8aD-4r7xA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uf4 CARBOXYPEPTIDASE A1

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		5 GLY A 388
SER A 309
SER A 307
PHE A 389
GLU A 380
 None
None
None
None
O2V  A1419 (-1.8A)
 1.46A 2c8aD-4uf4A:
undetectable		 2c8aD-4uf4A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4us5 LUCIFERASE-LIKE
MONOOXYGENASE

(Streptomyces
bottropensis) 		PF00296
(Bac_luciferase) 		4 GLY A  35
SER A   4
ARG A 334
GLU A 305
 None
 1.09A 2c8aD-4us5A:
undetectable		 2c8aD-4us5A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhj ENVELOPE
GLYCOPROTEIN H

(Human
alphaherpesvirus
3) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		4 GLY A 784
SER A 668
SER A 699
GLU A 643
 None
 1.10A 2c8aD-4xhjA:
undetectable		 2c8aD-4xhjA:
14.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xsh ADP-RIBOSYLTRANSFERA
SE

(Bacillus cereus) 		PF03496
(ADPrib_exo_Tox) 		5 ARG B  97
GLY B  98
SER B 142
ARG B 155
GLU B 185
 NAI  B 301 ( 2.7A)
NAI  B 301 (-4.3A)
NAI  B 301 (-3.3A)
NAI  B 301 (-3.1A)
NAI  B 301 (-3.2A)
 0.36A 2c8aD-4xshB:
26.6		 2c8aD-4xshB:
36.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a11 THIOCYANATE FORMING
PROTEIN

(Thlaspi arvense) 		PF01344
(Kelch_1) 		4 GLY A 185
SER A 249
PHE A 202
ARG A 157
 IOD  A1349 ( 3.8A)
None
None
IOD  A1349 (-4.5A)
 1.03A 2c8aD-5a11A:
undetectable		 2c8aD-5a11A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ams RIBOSOME ASSEMBLY
PROTEIN SQT1

(Saccharomyces
cerevisiae) 		no annotation 4 GLY A 107
SER A 111
SER A 130
GLU A 110
 None
 1.10A 2c8aD-5amsA:
undetectable		 2c8aD-5amsA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by3 BTGH115A

(Bacteroides
thetaiotaomicron) 		PF15979
(Glyco_hydro_115) 		4 GLY A 189
SER A 178
SER A 185
GLU A 183
 None
 1.04A 2c8aD-5by3A:
undetectable		 2c8aD-5by3A:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cdc VP1, STRUCTURAL
POLYPROTEIN

(Israeli acute
paralysis virus) 		PF08762
(CRPV_capsid) 		4 ARG A  92
GLY A  91
SER A 166
PHE A 147
 None
 1.06A 2c8aD-5cdcA:
undetectable		 2c8aD-5cdcA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cek TRIBBLES HOMOLOG 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 ARG A 218
GLY A 165
PHE A 164
GLU A 217
 None
 1.10A 2c8aD-5cekA:
undetectable		 2c8aD-5cekA:
21.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dzq TOXIN-LIKE PROTEIN

(Paenibacillus
larvae) 		PF03496
(ADPrib_exo_Tox) 		4 ARG A  73
GLY A  74
SER A 118
ARG A 130
 None
 0.93A 2c8aD-5dzqA:
22.6		 2c8aD-5dzqA:
36.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dzq TOXIN-LIKE PROTEIN

(Paenibacillus
larvae) 		PF03496
(ADPrib_exo_Tox) 		4 ARG A  73
GLY A  74
SER A 118
GLU A 158
 None
 0.87A 2c8aD-5dzqA:
22.6		 2c8aD-5dzqA:
36.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dzq TOXIN-LIKE PROTEIN

(Paenibacillus
larvae) 		PF03496
(ADPrib_exo_Tox) 		4 ARG A  73
GLY A  74
SER A 118
SER A 120
 None
 0.29A 2c8aD-5dzqA:
22.6		 2c8aD-5dzqA:
36.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmt ALGINATE LYASE

(Aplysia kurodai) 		no annotation 4 GLY A  97
SER A 239
SER A 242
ARG A 132
 None
 0.89A 2c8aD-5gmtA:
undetectable		 2c8aD-5gmtA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gq0 EPITHIOSPECIFIER
PROTEIN

(Arabidopsis
thaliana) 		no annotation 4 GLY B 185
SER B 243
PHE B 202
ARG B 157
 None
 1.05A 2c8aD-5gq0B:
undetectable		 2c8aD-5gq0B:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gs2 ANTI-REPEBODY

(Mus musculus) 		PF07686
(V-set) 		4 ARG D 192
GLY D 194
SER D 156
SER D 154
 None
 1.10A 2c8aD-5gs2D:
undetectable		 2c8aD-5gs2D:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h04 BINARY ENTEROTOXIN
OF CLOSTRIDIUM
PERFRINGENS
COMPONENT A

(Clostridium
perfringens) 		PF03496
(ADPrib_exo_Tox) 		5 ARG A 297
SER A 340
PHE A 351
ARG A 354
GLU A 382
 NAI  A 501 (-2.8A)
NAI  A 501 (-2.6A)
NAI  A 501 (-4.0A)
NAI  A 501 (-3.0A)
NAI  A 501 (-3.1A)
 0.75A 2c8aD-5h04A:
20.3		 2c8aD-5h04A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxz BARBITURASE

(Rhodococcus
erythropolis) 		PF09663
(Amido_AtzD_TrzD) 		4 GLY A  84
SER A 349
SER A 347
ARG A  53
 MHA  A 403 (-3.2A)
MHA  A 403 ( 4.6A)
MHA  A 403 (-2.8A)
MHA  A 403 (-3.1A)
 1.09A 2c8aD-5hxzA:
undetectable		 2c8aD-5hxzA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j90 RAGB/SUSD DOMAIN
PROTEIN

(Flavobacterium
johnsoniae) 		PF12741
(SusD-like) 		4 ARG A 219
GLY A 253
SER A 216
PHE A 252
 None
EDO  A 604 (-3.0A)
None
None
 1.10A 2c8aD-5j90A:
undetectable		 2c8aD-5j90A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jly THIOREDOXIN
PEROXIDASE-1

(Schistosoma
japonicum) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		4 GLY A 125
SER A  73
PHE A  38
ARG A 147
 None
 1.10A 2c8aD-5jlyA:
undetectable		 2c8aD-5jlyA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jwz CELLULOSE-BINDING
FAMILY II

(Streptomyces
sp. SirexAA-E) 		PF02012
(BNR) 		4 GLY A 274
SER A 302
SER A 320
GLU A 384
 None
 1.03A 2c8aD-5jwzA:
undetectable		 2c8aD-5jwzA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oev GLUTATHIONE
SYNTHETASE-LIKE
EFFECTOR 22
(GPA-GSS22-APO)

(Globodera
pallida) 		no annotation 4 GLY A 441
SER A 192
SER A 197
GLU A 196
 None
 0.77A 2c8aD-5oevA:
undetectable		 2c8aD-5oevA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT

(Homo sapiens) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		4 GLY A 735
SER A 707
SER A 705
GLU A 431
 None
 0.93A 2c8aD-5tusA:
undetectable		 2c8aD-5tusA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5urp TOXIN 2A

(Paenibacillus
larvae) 		no annotation 5 ARG A  83
GLY A  84
SER A 128
ARG A 140
GLU A 168
 None
None
GOL  A 301 ( 4.2A)
None
GOL  A 301 (-3.4A)
 0.89A 2c8aD-5urpA:
27.6		 2c8aD-5urpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5urp TOXIN 2A

(Paenibacillus
larvae) 		no annotation 4 GLY A  84
SER A 128
SER A 130
GLU A 168
 None
GOL  A 301 ( 4.2A)
GOL  A 301 ( 4.8A)
GOL  A 301 (-3.4A)
 0.87A 2c8aD-5urpA:
27.6		 2c8aD-5urpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnr ALYQ

(Persicobacter
sp. CCB-QB2) 		no annotation 4 GLY A 251
SER A 268
PHE A 296
GLU A 265
 None
 0.99A 2c8aD-5xnrA:
undetectable		 2c8aD-5xnrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ygr DIAMINOPROPIONATE
AMMONIA LYASE

(Salmonella
enterica) 		no annotation 4 GLY A 328
SER A 348
SER A 384
GLU A 386
 None
LLP  A  78 ( 4.4A)
None
LLP  A  78 ( 3.5A)
 1.03A 2c8aD-5ygrA:
undetectable		 2c8aD-5ygrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cuf -

(-) 		no annotation 4 GLY 8  65
SER 8  68
SER 8  82
GLU 8  81
 None
 0.97A 2c8aD-6cuf8:
undetectable		 2c8aD-6cuf8:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f79 -

(-) 		no annotation 4 GLY A 286
SER A 207
PHE A 287
GLU A 277
 None
None
None
0X9  A 407 (-3.2A)
 1.09A 2c8aD-6f79A:
undetectable		 2c8aD-6f79A:
undetectable