SIMILAR PATTERNS OF AMINO ACIDS FOR 2C8A_B_NCAB1246

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aye PROCARBOXYPEPTIDASE
A2

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		5 GLY A 278
SER A 199
SER A 197
PHE A 279
GLU A 270
 None
None
None
None
ZN  A 400 (-4.3A)
 1.26A 2c8aB-1ayeA:
undetectable		 2c8aB-1ayeA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dtd CARBOXYPEPTIDASE A2

(Homo sapiens) 		PF00246
(Peptidase_M14) 		5 GLY A 634
SER A 555
SER A 553
PHE A 635
GLU A 626
 None
None
None
None
GLU  A 300 (-4.2A)
 1.27A 2c8aB-1dtdA:
undetectable		 2c8aB-1dtdA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ewi REPLICATION PROTEIN
A

(Homo sapiens) 		PF04057
(Rep-A_N) 		4 GLY A 109
SER A 104
SER A  72
GLU A  69
 None
 0.99A 2c8aB-1ewiA:
undetectable		 2c8aB-1ewiA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ft5 CYTOCHROME C554

(Nitrosomonas
europaea) 		PF13435
(Cytochrome_C554) 		4 ARG A   8
GLY A  85
SER A  90
GLU A  89
 PO4  A 218 (-3.8A)
None
HEM  A 216 (-3.9A)
None
 1.04A 2c8aB-1ft5A:
undetectable		 2c8aB-1ft5A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gd7 CSAA PROTEIN

(Thermus
thermophilus) 		PF01588
(tRNA_bind) 		4 ARG A  73
GLY A  76
PHE A  77
GLU A  80
 None
 0.87A 2c8aB-1gd7A:
undetectable		 2c8aB-1gd7A:
19.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gze MONO-ADP-RIBOSYLTRAN
SFERASE C3

(Clostridium
botulinum) 		PF03496
(ADPrib_exo_Tox) 		4 ARG A 128
GLY A 129
SER A 174
GLU A 214
 None
 0.46A 2c8aB-1gzeA:
33.7		 2c8aB-1gzeA:
99.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hpl LIPASE

(Equus caballus) 		PF00151
(Lipase)
PF01477
(PLAT) 		4 GLY A 282
SER A 300
PHE A 325
GLU A 302
 None
 1.01A 2c8aB-1hplA:
undetectable		 2c8aB-1hplA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hqz ACTIN-BINDING
PROTEIN

(Saccharomyces
cerevisiae) 		PF00241
(Cofilin_ADF) 		4 GLY 1  67
SER 1  36
SER 1  47
GLU 1  46
 None
 0.95A 2c8aB-1hqz1:
undetectable		 2c8aB-1hqz1:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kwm PROCARBOXYPEPTIDASE
B

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		5 GLY A 278
SER A 199
SER A 197
PHE A 279
GLU A 270
 None
 1.32A 2c8aB-1kwmA:
undetectable		 2c8aB-1kwmA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5x SURVIVAL PROTEIN E

(Pyrobaculum
aerophilum) 		PF01975
(SurE) 		4 GLY A  42
SER A  67
SER A  36
GLU A  35
 None
 1.03A 2c8aB-1l5xA:
undetectable		 2c8aB-1l5xA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lt3 HEAT-LABILE
ENTEROTOXIN

(Escherichia
coli) 		PF01375
(Enterotoxin_a) 		4 ARG A   7
SER A  61
SER A  63
GLU A 112
 None
 0.90A 2c8aB-1lt3A:
undetectable		 2c8aB-1lt3A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ltt HEAT-LABILE
ENTEROTOXIN, SUBUNIT
A

(Escherichia
coli) 		PF01375
(Enterotoxin_a) 		4 ARG A   7
SER A  61
SER A  63
GLU A 112
 None
 0.65A 2c8aB-1lttA:
undetectable		 2c8aB-1lttA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mkm ICLR TRANSCRIPTIONAL
REGULATOR

(Thermotoga
maritima) 		PF01614
(IclR)
PF09339
(HTH_IclR) 		4 GLY A 206
SER A 241
PHE A 202
GLU A 238
 None
 0.99A 2c8aB-1mkmA:
undetectable		 2c8aB-1mkmA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nsa PROCARBOXYPEPTIDASE
B

(Sus scrofa) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		5 GLY A 278
SER A 199
SER A 197
PHE A 279
GLU A 270
 None
None
None
None
ZN  A 501 ( 4.9A)
 1.38A 2c8aB-1nsaA:
undetectable		 2c8aB-1nsaA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7d LYSOSOMAL
ALPHA-MANNOSIDASE
LYSOSOMAL
ALPHA-MANNOSIDASE

(Bos taurus;
Bos taurus) 		PF09261
(Alpha-mann_mid)
PF07748
(Glyco_hydro_38C) 		4 GLY B 390
PHE D 662
ARG D 815
GLU D 769
 None
 1.08A 2c8aB-1o7dB:
undetectable		 2c8aB-1o7dB:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oyz HYPOTHETICAL PROTEIN
YIBA

(Escherichia
coli) 		PF13646
(HEAT_2) 		4 GLY A  74
SER A 114
PHE A  76
GLU A 113
 None
 1.02A 2c8aB-1oyzA:
undetectable		 2c8aB-1oyzA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qs2 ADP-RIBOSYLTRANSFERA
SE

(Bacillus cereus) 		PF03496
(ADPrib_exo_Tox) 		4 ARG A 349
SER A 386
ARG A 400
GLU A 428
 NAD  A 500 (-3.7A)
NAD  A 500 ( 3.8A)
NAD  A 500 (-3.6A)
NAD  A 500 (-2.8A)
 0.77A 2c8aB-1qs2A:
19.7		 2c8aB-1qs2A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qs2 ADP-RIBOSYLTRANSFERA
SE

(Bacillus cereus) 		PF03496
(ADPrib_exo_Tox) 		4 ARG A 349
SER A 386
PHE A 397
ARG A 400
 NAD  A 500 (-3.7A)
NAD  A 500 ( 3.8A)
NAD  A 500 (-3.5A)
NAD  A 500 (-3.6A)
 0.90A 2c8aB-1qs2A:
19.7		 2c8aB-1qs2A:
23.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r45 MONO-ADP-RIBOSYLTRAN
SFERASE C3

(Clostridium
phage c-st) 		PF03496
(ADPrib_exo_Tox) 		4 GLY A 129
SER A 174
ARG A 185
GLU A 213
 None
 0.80A 2c8aB-1r45A:
30.3		 2c8aB-1r45A:
63.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s5f CHOLERA ENTEROTOXIN,
A CHAIN

(Vibrio cholerae) 		PF01375
(Enterotoxin_a) 		4 ARG A   7
SER A  61
SER A  63
GLU A 112
 None
 0.93A 2c8aB-1s5fA:
undetectable		 2c8aB-1s5fA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlj NADH-DEPENDENT
BUTANOL
DEHYDROGENASE

(Thermotoga
maritima) 		PF00465
(Fe-ADH) 		4 ARG A 377
GLY A 263
SER A 208
GLU A   2
 None
 0.98A 2c8aB-1vljA:
undetectable		 2c8aB-1vljA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vp6 CYCLIC-NUCLEOTIDE
BINDING DOMAIN OF
MESORHIZOBIUM LOTI
CNG POTASSIUM
CHANNEL

(Mesorhizobium
loti) 		PF00027
(cNMP_binding) 		4 GLY A 259
SER A 279
SER A 281
GLU A 289
 BR  A 360 ( 3.7A)
None
None
None
 0.90A 2c8aB-1vp6A:
undetectable		 2c8aB-1vp6A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zli CARBOXYPEPTIDASE B

(Homo sapiens) 		PF00246
(Peptidase_M14) 		5 GLY A 278
SER A 199
SER A 197
PHE A 279
GLU A 270
 None
None
None
None
ZN  A 501 ( 4.8A)
 1.33A 2c8aB-1zliA:
undetectable		 2c8aB-1zliA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zye THIOREDOXIN-DEPENDEN
T PEROXIDE REDUCTASE

(Bos taurus) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		4 GLY A 124
SER A  72
PHE A  37
ARG A 146
 None
 0.92A 2c8aB-1zyeA:
undetectable		 2c8aB-1zyeA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aif RIBOSOMAL PROTEIN
L7A

(Cryptosporidium
parvum) 		PF01248
(Ribosomal_L7Ae) 		4 GLY A 114
SER A 111
SER A 118
GLU A  57
 None
 0.92A 2c8aB-2aifA:
undetectable		 2c8aB-2aifA:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1

(Homo sapiens) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		4 GLY A 777
SER A 674
ARG A 536
GLU A 773
 None
 0.99A 2c8aB-2b3xA:
undetectable		 2c8aB-2b3xA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2boa CARBOXYPEPTIDASE A4

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		5 GLY A1278
SER A1199
SER A1197
PHE A1279
GLU A1270
 None
 1.27A 2c8aB-2boaA:
undetectable		 2c8aB-2boaA:
20.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2bov MONO-ADP-RIBOSYLTRAN
SFERASE C3

(Clostridium
botulinum) 		PF03496
(ADPrib_exo_Tox) 		5 ARG B1128
GLY B1129
SER B1174
ARG B1186
GLU B1214
 None
 0.92A 2c8aB-2bovB:
33.0		 2c8aB-2bovB:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0h MANNAN
ENDO-1,4-BETA-MANNOS
IDASE

(Mytilus edulis) 		PF00150
(Cellulase) 		4 GLY A 316
SER A 319
SER A 321
GLU A 320
 None
 0.95A 2c8aB-2c0hA:
undetectable		 2c8aB-2c0hA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pcu CARBOXYPEPTIDASE A4

(Homo sapiens) 		PF00246
(Peptidase_M14) 		5 GLY A 278
SER A 199
SER A 197
PHE A 279
GLU A 270
 None
None
None
None
ZN  A 999 (-4.6A)
 1.30A 2c8aB-2pcuA:
undetectable		 2c8aB-2pcuA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal disease
virus) 		PF04197
(Birna_RdRp) 		4 SER A 687
SER A 689
ARG A 627
GLU A 688
 None
 0.97A 2c8aB-2pggA:
undetectable		 2c8aB-2pggA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ptm HYPERPOLARIZATION-AC
TIVATED (IH) CHANNEL

(Strongylocentrotus
purpuratus) 		PF00027
(cNMP_binding) 		4 GLY A 610
SER A 634
ARG A 620
GLU A 564
 CMP  A 401 (-3.2A)
None
CMP  A 401 (-4.0A)
None
 0.93A 2c8aB-2ptmA:
undetectable		 2c8aB-2ptmA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q0a POTASSIUM/SODIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 2

(Mus musculus) 		PF00027
(cNMP_binding) 		4 GLY A 581
SER A 605
ARG A 591
GLU A 536
 PCG  A 401 (-3.3A)
None
PCG  A 401 (-4.0A)
None
 1.02A 2c8aB-2q0aA:
undetectable		 2c8aB-2q0aA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uux TRYPTASE INHIBITOR

(Rhipicephalus
appendiculatus) 		no annotation 4 ARG A  44
GLY A  61
SER A  64
GLU A  68
 None
 0.77A 2c8aB-2uuxA:
undetectable		 2c8aB-2uuxA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w20 SIALIDASE A

(Streptococcus
pneumoniae) 		PF13088
(BNR_2) 		4 ARG A 334
GLY A 773
SER A 332
GLU A 331
 None
 1.07A 2c8aB-2w20A:
undetectable		 2c8aB-2w20A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wgh RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT

(Homo sapiens) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC) 		4 GLY A 735
SER A 707
SER A 705
GLU A 431
 None
 0.99A 2c8aB-2wghA:
undetectable		 2c8aB-2wghA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wn4 ADP-RIBOSYLTRANSFERA
SE ENZYMATIC
COMPONENT

(Clostridioides
difficile) 		PF03496
(ADPrib_exo_Tox) 		5 ARG A 302
SER A 345
PHE A 356
ARG A 359
GLU A 387
 None
 1.19A 2c8aB-2wn4A:
23.3		 2c8aB-2wn4A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xtz GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-1
SUBUNIT

(Arabidopsis
thaliana) 		PF00503
(G-alpha) 		4 GLY A 221
SER A  49
ARG A 226
GLU A 247
 GSP  A1382 (-3.4A)
GSP  A1382 (-3.4A)
None
None
 1.05A 2c8aB-2xtzA:
undetectable		 2c8aB-2xtzA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bex TYPE III
PANTOTHENATE KINASE

(Thermotoga
maritima) 		PF03309
(Pan_kinase) 		4 GLY A  56
SER A  81
SER A  74
GLU A  71
 None
 0.94A 2c8aB-3bexA:
undetectable		 2c8aB-3bexA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3buz IOTA TOXIN COMPONENT
IA

(Clostridium
perfringens) 		PF03496
(ADPrib_exo_Tox) 		4 ARG A 295
SER A 338
ARG A 352
GLU A 380
 TAD  A 500 (-3.2A)
TAD  A 500 (-3.2A)
TAD  A 500 (-2.7A)
TAD  A 500 (-2.6A)
 0.75A 2c8aB-3buzA:
22.9		 2c8aB-3buzA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bvp TP901-1 INTEGRASE

(Lactococcus
phage TP901-1) 		PF00239
(Resolvase) 		4 GLY A 119
SER A 107
PHE A 122
GLU A 110
 None
 1.02A 2c8aB-3bvpA:
undetectable		 2c8aB-3bvpA:
25.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3bw8 MONO-ADP-RIBOSYLTRAN
SFERASE C3

(Hathewaya
limosa) 		PF03496
(ADPrib_exo_Tox) 		5 ARG A  88
GLY A  89
SER A 134
ARG A 146
GLU A 174
 None
 0.33A 2c8aB-3bw8A:
31.4		 2c8aB-3bw8A:
59.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cx6 GUANINE
NUCLEOTIDE-BINDING
PROTEIN ALPHA-13
SUBUNIT

(Mus musculus) 		PF00503
(G-alpha) 		4 GLY A 225
SER A  59
ARG A 230
GLU A 251
 None
GDP  A 775 (-3.4A)
None
None
 1.06A 2c8aB-3cx6A:
undetectable		 2c8aB-3cx6A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d4u CARBOXYPEPTIDASE B2

(Bos taurus) 		PF00246
(Peptidase_M14) 		5 GLY A 278
SER A 199
SER A 197
PHE A 279
GLU A 270
 None
None
None
None
ZN  A 309 ( 4.8A)
 1.34A 2c8aB-3d4uA:
undetectable		 2c8aB-3d4uA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e58 PUTATIVE
BETA-PHOSPHOGLUCOMUT
ASE

(Streptococcus
thermophilus) 		PF13419
(HAD_2) 		4 GLY A  46
SER A  41
SER A 168
GLU A 169
 None
 0.96A 2c8aB-3e58A:
undetectable		 2c8aB-3e58A:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fii BOTULINUM NEUROTOXIN
TYPE F

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		4 ARG A  49
GLY A 159
SER A 196
GLU A 198
 None
 1.04A 2c8aB-3fiiA:
undetectable		 2c8aB-3fiiA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fju CARBOXYPEPTIDASE A1

(Homo sapiens) 		PF00246
(Peptidase_M14) 		5 GLY A 278
SER A 199
SER A 197
PHE A 279
GLU A 270
 None
None
None
None
ACT  A 515 (-4.3A)
 1.29A 2c8aB-3fjuA:
undetectable		 2c8aB-3fjuA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjg PUTATIVE
ALPHA-RIBAZOLE-5'-PH
OSPHATE PHOSPHATASE
COBC

(Vibrio
parahaemolyticus) 		PF00300
(His_Phos_1) 		4 ARG A  10
GLY A 148
SER A 178
ARG A 152
 SO4  A 212 (-3.4A)
SO4  A 212 (-4.2A)
None
None
 1.09A 2c8aB-3hjgA:
undetectable		 2c8aB-3hjgA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lms CARBOXYPEPTIDASE B2

(Homo sapiens) 		PF00246
(Peptidase_M14) 		5 GLY A 278
SER A 199
SER A 197
PHE A 279
GLU A 270
 None
None
None
None
GLY  A 501 ( 4.6A)
 1.37A 2c8aB-3lmsA:
undetectable		 2c8aB-3lmsA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nnk UREIDOGLYCINE-GLYOXY
LATE
AMINOTRANSFERASE

(Klebsiella
pneumoniae) 		PF00266
(Aminotran_5) 		4 GLY A 326
SER A 150
SER A 353
PHE A 314
 None
 0.93A 2c8aB-3nnkA:
undetectable		 2c8aB-3nnkA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3osl CARBOXYPEPTIDASE B2

(Bos taurus) 		PF00246
(Peptidase_M14) 		5 GLY A 393
SER A 313
SER A 311
PHE A 394
GLU A 385
 None
None
None
None
ZN  A 999 ( 4.8A)
 1.34A 2c8aB-3oslA:
undetectable		 2c8aB-3oslA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sju KETO REDUCTASE

(Streptomyces
griseoruber) 		PF00106
(adh_short) 		4 ARG A 118
GLY A 115
SER A  64
GLU A  67
 None
 1.04A 2c8aB-3sjuA:
undetectable		 2c8aB-3sjuA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sm3 SAM-DEPENDENT
METHYLTRANSFERASES

(Methanosarcina
mazei) 		PF08241
(Methyltransf_11) 		4 GLY A 143
SER A 167
PHE A 185
GLU A 164
 None
 0.92A 2c8aB-3sm3A:
undetectable		 2c8aB-3sm3A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ts0 PROTEIN LIN-28
HOMOLOG A

(Mus musculus) 		PF00098
(zf-CCHC)
PF00313
(CSD) 		4 ARG A  85
GLY A  83
SER A  86
PHE A  84
 G  U   7 ( 3.3A)
None
None
A  U   6 ( 3.3A)
 1.05A 2c8aB-3ts0A:
undetectable		 2c8aB-3ts0A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uhj PROBABLE GLYCEROL
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00465
(Fe-ADH) 		4 GLY A 266
SER A 196
PHE A 269
GLU A 200
 None
 1.00A 2c8aB-3uhjA:
undetectable		 2c8aB-3uhjA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ure ALPHA-LYTIC PROTEASE

(Lysobacter
enzymogenes) 		PF00089
(Trypsin) 		4 GLY A  56
SER A 214
PHE A  94
ARG A  90
 None
 0.97A 2c8aB-3ureA:
undetectable		 2c8aB-3ureA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zvj THIOREDOXIN
PEROXIDASE

(Schistosoma
mansoni) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		4 GLY D 125
SER D  73
PHE D  38
ARG D 147
 None
 0.95A 2c8aB-3zvjD:
undetectable		 2c8aB-3zvjD:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ag4 EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1
MONOCLONAL ANTIBODY
3E3 HEAVY CHAIN

(Homo sapiens;
Mus musculus) 		PF00754
(F5_F8_type_C)
PF07654
(C1-set)
PF07686
(V-set) 		4 ARG A 341
GLY A 315
SER H  32
SER H  30
 None
 1.09A 2c8aB-4ag4A:
undetectable		 2c8aB-4ag4A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c9g ADP, ATP CARRIER
PROTEIN 2

(Saccharomyces
cerevisiae) 		PF00153
(Mito_carr) 		4 GLY A  89
SER A  85
ARG A 152
GLU A  81
 GLY  A  89 (-0.0A)
SER  A  85 ( 0.0A)
ARG  A 152 ( 0.6A)
GLU  A  81 ( 0.6A)
 0.93A 2c8aB-4c9gA:
undetectable		 2c8aB-4c9gA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fk7 PUTATIVE
ADP-RIBOSYLTRANSFERA
SE CERTHRAX

(Bacillus cereus) 		PF03496
(ADPrib_exo_Tox) 		4 ARG A 341
SER A 387
SER A 389
GLU A 431
 P34  A1001 (-3.6A)
P34  A1001 (-4.0A)
P34  A1001 (-3.1A)
P34  A1001 (-3.9A)
 0.57A 2c8aB-4fk7A:
23.9		 2c8aB-4fk7A:
27.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnq ALPHA-GALACTOSIDASE
AGAB

(Geobacillus
stearothermophilus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		4 GLY A 531
SER A 525
PHE A 533
GLU A 524
 None
 1.03A 2c8aB-4fnqA:
undetectable		 2c8aB-4fnqA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnq ALPHA-GALACTOSIDASE
AGAB

(Geobacillus
stearothermophilus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		4 SER A 525
PHE A 533
ARG A 203
GLU A 524
 None
 0.90A 2c8aB-4fnqA:
undetectable		 2c8aB-4fnqA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4frx ANAEROBICALLY-INDUCE
D OUTER MEMBRANE
PORIN OPRE

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		4 ARG A 163
GLY A 130
SER A 315
ARG A 421
 None
 1.09A 2c8aB-4frxA:
undetectable		 2c8aB-4frxA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxq PUTATIVE
ADP-RIBOSYLTRANSFERA
SE CERTHRAX

(Bacillus cereus) 		PF03496
(ADPrib_exo_Tox)
PF07737
(ATLF) 		4 ARG A 341
SER A 387
SER A 389
GLU A 431
 CL  A 503 ( 4.1A)
G9L  A 501 (-4.2A)
G9L  A 501 (-3.0A)
G9L  A 501 (-3.7A)
 0.50A 2c8aB-4fxqA:
24.5		 2c8aB-4fxqA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0c PHOSPHOLIPASE/CARBOX
YLESTERASE

(Dyadobacter
fermentans) 		PF02230
(Abhydrolase_2) 		4 GLY A 130
SER A 165
SER A 170
GLU A 169
 CIT  A 301 (-3.4A)
None
None
None
 0.90A 2c8aB-4h0cA:
undetectable		 2c8aB-4h0cA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iql ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE
II

(Porphyromonas
gingivalis) 		PF03060
(NMO) 		4 GLY A 192
SER A 198
PHE A 195
GLU A 289
 FMN  A 401 (-3.4A)
None
None
None
 1.09A 2c8aB-4iqlA:
undetectable		 2c8aB-4iqlA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jx0 HYPOTHETICAL PROTEIN

(Bacteroides
fragilis) 		PF08522
(DUF1735) 		4 GLY A 296
SER A 280
SER A 204
ARG A 198
 None
 0.98A 2c8aB-4jx0A:
undetectable		 2c8aB-4jx0A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nq3 CYANURIC ACID
AMIDOHYDROLASE

(Azorhizobium
caulinodans) 		PF09663
(Amido_AtzD_TrzD) 		4 ARG A 188
GLY A 334
SER A 227
SER A  79
 BR8  A 401 (-4.1A)
BR8  A 401 (-3.6A)
BR8  A 401 (-4.8A)
BR8  A 401 (-2.7A)
 1.08A 2c8aB-4nq3A:
undetectable		 2c8aB-4nq3A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4olp GRPU
MICROCOMPARTMENT
SHELL PROTEIN

(Pectobacterium
parmentieri) 		PF00936
(BMC) 		4 ARG A  26
SER A  23
SER A  25
GLU A  24
 None
 0.84A 2c8aB-4olpA:
undetectable		 2c8aB-4olpA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qrl HYPOTHETICAL PROTEIN

(Bacteroides
uniformis) 		PF16585
(Lipocalin_8) 		4 GLY A  75
SER A  92
PHE A  74
GLU A  91
 None
 0.99A 2c8aB-4qrlA:
undetectable		 2c8aB-4qrlA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7v ARRESTIN
DOMAIN-CONTAINING
PROTEIN 3

(Homo sapiens) 		PF00339
(Arrestin_N) 		4 GLY A  53
SER A 133
ARG A  52
GLU A 128
 None
 0.91A 2c8aB-4r7vA:
undetectable		 2c8aB-4r7vA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7v ARRESTIN
DOMAIN-CONTAINING
PROTEIN 3

(Homo sapiens) 		PF00339
(Arrestin_N) 		4 GLY A  53
SER A 133
SER A 126
GLU A 128
 None
 1.04A 2c8aB-4r7vA:
undetectable		 2c8aB-4r7vA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7x ARRESTIN
DOMAIN-CONTAINING
PROTEIN 3

(Homo sapiens) 		PF00339
(Arrestin_N) 		4 GLY A  53
SER A 133
SER A 126
GLU A 128
 None
 0.88A 2c8aB-4r7xA:
undetectable		 2c8aB-4r7xA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uf4 CARBOXYPEPTIDASE A1

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		5 GLY A 388
SER A 309
SER A 307
PHE A 389
GLU A 380
 None
None
None
None
O2V  A1419 (-1.8A)
 1.42A 2c8aB-4uf4A:
undetectable		 2c8aB-4uf4A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4us5 LUCIFERASE-LIKE
MONOOXYGENASE

(Streptomyces
bottropensis) 		PF00296
(Bac_luciferase) 		4 GLY A  35
SER A   4
ARG A 334
GLU A 305
 None
 0.91A 2c8aB-4us5A:
undetectable		 2c8aB-4us5A:
19.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xsh ADP-RIBOSYLTRANSFERA
SE

(Bacillus cereus) 		PF03496
(ADPrib_exo_Tox) 		5 ARG B  97
GLY B  98
SER B 142
ARG B 155
GLU B 185
 NAI  B 301 ( 2.7A)
NAI  B 301 (-4.3A)
NAI  B 301 (-3.3A)
NAI  B 301 (-3.1A)
NAI  B 301 (-3.2A)
 0.47A 2c8aB-4xshB:
26.7		 2c8aB-4xshB:
36.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by3 BTGH115A

(Bacteroides
thetaiotaomicron) 		PF15979
(Glyco_hydro_115) 		4 GLY A 189
SER A 178
SER A 185
GLU A 183
 None
 0.98A 2c8aB-5by3A:
undetectable		 2c8aB-5by3A:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cdc VP1, STRUCTURAL
POLYPROTEIN

(Israeli acute
paralysis virus) 		PF08762
(CRPV_capsid) 		4 ARG A  92
GLY A  91
SER A 166
PHE A 147
 None
 1.00A 2c8aB-5cdcA:
undetectable		 2c8aB-5cdcA:
23.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dzq TOXIN-LIKE PROTEIN

(Paenibacillus
larvae) 		PF03496
(ADPrib_exo_Tox) 		5 ARG A  73
GLY A  74
SER A 118
ARG A 130
GLU A 158
 None
 1.26A 2c8aB-5dzqA:
22.6		 2c8aB-5dzqA:
36.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dzq TOXIN-LIKE PROTEIN

(Paenibacillus
larvae) 		PF03496
(ADPrib_exo_Tox) 		5 ARG A  73
GLY A  74
SER A 118
SER A 120
ARG A 130
 None
 1.08A 2c8aB-5dzqA:
22.6		 2c8aB-5dzqA:
36.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fqd CASEIN KINASE I
ISOFORM ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		4 ARG C 123
GLY C  72
SER C 122
GLU C 125
 None
 0.95A 2c8aB-5fqdC:
undetectable		 2c8aB-5fqdC:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmt ALGINATE LYASE

(Aplysia kurodai) 		no annotation 4 GLY A  97
SER A 239
SER A 242
ARG A 132
 None
 0.88A 2c8aB-5gmtA:
undetectable		 2c8aB-5gmtA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqt NITRILE-SPECIFIER
PROTEIN 1

(Arabidopsis
thaliana) 		PF01344
(Kelch_1)
PF01419
(Jacalin)
PF13415
(Kelch_3) 		4 GLY A 320
SER A 369
PHE A 337
ARG A 292
 None
 0.97A 2c8aB-5gqtA:
undetectable		 2c8aB-5gqtA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gs2 ANTI-REPEBODY

(Mus musculus) 		PF07686
(V-set) 		4 ARG D 192
GLY D 194
SER D 156
SER D 154
 None
 1.04A 2c8aB-5gs2D:
undetectable		 2c8aB-5gs2D:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h04 BINARY ENTEROTOXIN
OF CLOSTRIDIUM
PERFRINGENS
COMPONENT A

(Clostridium
perfringens) 		PF03496
(ADPrib_exo_Tox) 		5 ARG A 297
SER A 340
PHE A 351
ARG A 354
GLU A 382
 NAI  A 501 (-2.8A)
NAI  A 501 (-2.6A)
NAI  A 501 (-4.0A)
NAI  A 501 (-3.0A)
NAI  A 501 (-3.1A)
 0.86A 2c8aB-5h04A:
20.0		 2c8aB-5h04A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hvf CARBOXYPEPTIDASE B2

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		5 GLY A 371
SER A 291
SER A 289
PHE A 372
GLU A 363
 None
None
None
None
FLC  A 509 (-3.3A)
 1.27A 2c8aB-5hvfA:
undetectable		 2c8aB-5hvfA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1q CARBOXYPEPTIDASE B

(Sus scrofa) 		PF00246
(Peptidase_M14) 		5 GLY A 278
SER A 199
SER A 197
PHE A 279
GLU A 270
 None
None
None
None
CXA  A 402 (-3.0A)
 1.30A 2c8aB-5j1qA:
undetectable		 2c8aB-5j1qA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jcg THIOREDOXIN-DEPENDEN
T PEROXIDE
REDUCTASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		4 GLY A 124
SER A  72
PHE A  37
ARG A 146
 None
 0.97A 2c8aB-5jcgA:
undetectable		 2c8aB-5jcgA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jly THIOREDOXIN
PEROXIDASE-1

(Schistosoma
japonicum) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		4 GLY A 125
SER A  73
PHE A  38
ARG A 147
 None
 0.96A 2c8aB-5jlyA:
undetectable		 2c8aB-5jlyA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jon MALTOSE-BINDING
PERIPLASMIC
PROTEIN,POTASSIUM/SO
DIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 2

(Escherichia
coli;
Mus musculus) 		PF00027
(cNMP_binding)
PF13416
(SBP_bac_8) 		4 GLY A 581
SER A 605
ARG A 591
GLU A 536
 NO3  A 702 (-3.3A)
None
NO3  A 702 (-4.2A)
None
 0.99A 2c8aB-5jonA:
undetectable		 2c8aB-5jonA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jwz CELLULOSE-BINDING
FAMILY II

(Streptomyces
sp. SirexAA-E) 		PF02012
(BNR) 		4 GLY A 274
SER A 302
SER A 320
GLU A 384
 None
 1.00A 2c8aB-5jwzA:
undetectable		 2c8aB-5jwzA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oev GLUTATHIONE
SYNTHETASE-LIKE
EFFECTOR 22
(GPA-GSS22-APO)

(Globodera
pallida) 		no annotation 4 GLY A 441
SER A 192
SER A 197
GLU A 196
 None
 0.79A 2c8aB-5oevA:
undetectable		 2c8aB-5oevA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tus RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE SUBUNIT

(Homo sapiens) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		4 GLY A 735
SER A 707
SER A 705
GLU A 431
 None
 0.93A 2c8aB-5tusA:
undetectable		 2c8aB-5tusA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5urp TOXIN 2A

(Paenibacillus
larvae) 		no annotation 4 ARG A  83
GLY A  84
SER A 128
ARG A 140
 None
None
GOL  A 301 ( 4.2A)
None
 0.75A 2c8aB-5urpA:
27.4		 2c8aB-5urpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5urp TOXIN 2A

(Paenibacillus
larvae) 		no annotation 4 ARG A  83
GLY A  84
SER A 128
GLU A 168
 None
None
GOL  A 301 ( 4.2A)
GOL  A 301 (-3.4A)
 0.32A 2c8aB-5urpA:
27.4		 2c8aB-5urpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5urp TOXIN 2A

(Paenibacillus
larvae) 		no annotation 4 GLY A  84
SER A 128
SER A 130
GLU A 168
 None
GOL  A 301 ( 4.2A)
GOL  A 301 ( 4.8A)
GOL  A 301 (-3.4A)
 0.87A 2c8aB-5urpA:
27.4		 2c8aB-5urpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnr ALYQ

(Persicobacter
sp. CCB-QB2) 		no annotation 4 GLY A 251
SER A 268
PHE A 296
GLU A 265
 None
 0.96A 2c8aB-5xnrA:
undetectable		 2c8aB-5xnrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ygr DIAMINOPROPIONATE
AMMONIA LYASE

(Salmonella
enterica) 		no annotation 4 GLY A 328
SER A 348
SER A 384
GLU A 386
 None
LLP  A  78 ( 4.4A)
None
LLP  A  78 ( 3.5A)
 1.05A 2c8aB-5ygrA:
undetectable		 2c8aB-5ygrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cuf -

(-) 		no annotation 4 GLY 8  65
SER 8  68
SER 8  82
GLU 8  81
 None
 0.93A 2c8aB-6cuf8:
undetectable		 2c8aB-6cuf8:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f79 -

(-) 		no annotation 4 GLY A 286
SER A 207
PHE A 287
GLU A 277
 None
None
None
0X9  A 407 (-3.2A)
 1.02A 2c8aB-6f79A:
undetectable		 2c8aB-6f79A:
undetectable