SIMILAR PATTERNS OF AMINO ACIDS FOR 2C6N_B_LPRB705_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aw9 GLUTATHIONE
S-TRANSFERASE III


(Zea mays)
PF00043
(GST_C)
PF02798
(GST_N)
3 ALA A 170
THR A  20
PHE A 107
None
0.78A 2c6nB-1aw9A:
0.0
2c6nB-1aw9A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cns CHITINASE

(Hordeum vulgare)
PF00182
(Glyco_hydro_19)
3 ALA A 154
THR A  64
PHE A  41
None
0.64A 2c6nB-1cnsA:
0.0
2c6nB-1cnsA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dxj CLASS II CHITINASE

(Canavalia
ensiformis)
PF00182
(Glyco_hydro_19)
3 ALA A 153
THR A  65
PHE A  42
None
0.67A 2c6nB-1dxjA:
0.0
2c6nB-1dxjA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gdh D-GLYCERATE
DEHYDROGENASE


(Hyphomicrobium
methylovorum)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
3 ALA A 161
THR A 102
PHE A 155
None
SO4  A 322 (-3.7A)
None
0.78A 2c6nB-1gdhA:
0.0
2c6nB-1gdhA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ka9 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE


(Thermus
thermophilus)
PF00977
(His_biosynth)
3 ALA F 201
THR F 188
PHE F 211
None
0.77A 2c6nB-1ka9F:
0.0
2c6nB-1ka9F:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7r HYALURONIDASE

(Streptococcus
pneumoniae)
PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N)
3 ALA A 653
THR A 553
PHE A 671
None
0.65A 2c6nB-1n7rA:
0.3
2c6nB-1n7rA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ohf NUDAURELIA CAPENSIS
OMEGA VIRUS CAPSID
PROTEIN


(Nudaurelia
capensis omega
virus)
PF03566
(Peptidase_A21)
3 ALA A 163
THR A 522
PHE A 165
None
0.70A 2c6nB-1ohfA:
0.0
2c6nB-1ohfA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r47 ALPHA-GALACTOSIDASE
A


(Homo sapiens)
PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C)
3 ALA A 156
THR A 194
PHE A 169
None
0.71A 2c6nB-1r47A:
0.0
2c6nB-1r47A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uan HYPOTHETICAL PROTEIN
TT1542


(Thermus
thermophilus)
PF02585
(PIG-L)
3 ALA A  25
THR A  32
PHE A 162
None
0.74A 2c6nB-1uanA:
undetectable
2c6nB-1uanA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulq PUTATIVE ACETYL-COA
ACETYLTRANSFERASE


(Thermus
thermophilus)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
3 ALA A 327
THR A 246
PHE A 184
None
0.76A 2c6nB-1ulqA:
undetectable
2c6nB-1ulqA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5b 3-ISOPROPYLMALATE
DEHYDROGENASE


(Bacillus
coagulans)
PF00180
(Iso_dh)
3 ALA A  21
THR A 296
PHE A  38
None
0.78A 2c6nB-1v5bA:
undetectable
2c6nB-1v5bA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v93 5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE


(Thermus
thermophilus)
PF02219
(MTHFR)
3 ALA A 279
THR A 212
PHE A 271
None
None
DIO  A 301 (-4.9A)
0.79A 2c6nB-1v93A:
undetectable
2c6nB-1v93A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vef ACETYLORNITHINE/ACET
YL-LYSINE
AMINOTRANSFERASE


(Thermus
thermophilus)
PF00202
(Aminotran_3)
3 ALA A 120
THR A 251
PHE A 133
None
0.67A 2c6nB-1vefA:
undetectable
2c6nB-1vefA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdw TRYPTOPHAN SYNTHASE
ALPHA CHAIN


(Pyrococcus
furiosus)
PF00290
(Trp_syntA)
3 ALA A  27
THR A 235
PHE A  75
None
0.71A 2c6nB-1wdwA:
undetectable
2c6nB-1wdwA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wye 2-KETO-3-DEOXYGLUCON
ATE KINASE


(Sulfurisphaera
tokodaii)
PF00294
(PfkB)
3 ALA A 282
THR A 261
PHE A 305
None
0.66A 2c6nB-1wyeA:
undetectable
2c6nB-1wyeA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE


(Salmonella
enterica)
PF04223
(CitF)
3 ALA A 277
THR A 406
PHE A 284
None
0.77A 2c6nB-1xr4A:
undetectable
2c6nB-1xr4A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7e PROBABLE M18-FAMILY
AMINOPEPTIDASE 1


(Borreliella
burgdorferi)
PF02127
(Peptidase_M18)
3 ALA A 448
THR A 262
PHE A 443
None
0.76A 2c6nB-1y7eA:
undetectable
2c6nB-1y7eA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ykg SULFITE REDUCTASE
[NADPH] FLAVOPROTEIN
ALPHA-COMPONENT


(Escherichia
coli)
PF00258
(Flavodoxin_1)
3 ALA A 127
THR A 115
PHE A 102
None
0.75A 2c6nB-1ykgA:
undetectable
2c6nB-1ykgA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9f SINGLE-STRAND
BINDING PROTEIN


(Thermotoga
maritima)
PF00436
(SSB)
3 ALA A  65
THR A  57
PHE A 106
None
0.63A 2c6nB-1z9fA:
undetectable
2c6nB-1z9fA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cas CANINE PARVOVIRUS
EMPTY CAPSID (STRAIN
D) VIRAL PROTEIN 2


(Carnivore
protoparvovirus
1)
PF00740
(Parvo_coat)
3 ALA A 188
THR A 206
PHE A 185
None
0.74A 2c6nB-2casA:
undetectable
2c6nB-2casA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cqy PROPIONYL-COA
CARBOXYLASE ALPHA
CHAIN, MITOCHONDRIAL


(Homo sapiens)
PF02786
(CPSase_L_D2)
3 ALA A  37
THR A  70
PHE A  27
None
0.69A 2c6nB-2cqyA:
undetectable
2c6nB-2cqyA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9y ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
BETA


(Escherichia
coli)
PF01039
(Carboxyl_trans)
3 ALA B 211
THR B 202
PHE B 142
None
0.79A 2c6nB-2f9yB:
undetectable
2c6nB-2f9yB:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2faf PHOSPHOENOLPYRUVATE
CARBOXYKINASE


(Gallus gallus)
PF00821
(PEPCK_C)
PF17297
(PEPCK_N)
3 ALA A 366
THR A 358
PHE A 351
None
0.61A 2c6nB-2fafA:
undetectable
2c6nB-2fafA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hay PUTATIVE
NAD(P)H-FLAVIN
OXIDOREDUCTASE


(Streptococcus
pyogenes)
PF00881
(Nitroreductase)
3 ALA A  38
THR A 155
PHE A  53
None
0.77A 2c6nB-2hayA:
undetectable
2c6nB-2hayA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hrz NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE


(Agrobacterium
fabrum)
PF01370
(Epimerase)
3 ALA A 164
THR A 153
PHE A 132
None
0.71A 2c6nB-2hrzA:
undetectable
2c6nB-2hrzA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3r ZGC 92866

(Danio rerio)
PF04051
(TRAPP)
3 ALA B 140
THR B 168
PHE B  33
NO3  B1177 (-3.1A)
NO3  B1177 ( 3.7A)
None
0.78A 2c6nB-2j3rB:
undetectable
2c6nB-2j3rB:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jb1 L-AMINO ACID OXIDASE

(Rhodococcus
opacus)
PF01593
(Amino_oxidase)
3 ALA A  23
THR A 292
PHE A 246
FAD  A1489 (-3.2A)
FAD  A1489 ( 4.7A)
None
0.79A 2c6nB-2jb1A:
undetectable
2c6nB-2jb1A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE


(Nostoc
punctiforme)
PF00221
(Lyase_aromatic)
3 ALA A 251
THR A 508
PHE A 264
None
0.71A 2c6nB-2nyfA:
0.0
2c6nB-2nyfA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2or2 1-PHOSPHATIDYLINOSIT
OL PHOSPHODIESTERASE


(Bacillus
thuringiensis)
PF00388
(PI-PLC-X)
3 ALA A  63
THR A  31
PHE A 101
None
0.60A 2c6nB-2or2A:
undetectable
2c6nB-2or2A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pb0 ACETYLORNITHINE/SUCC
INYLDIAMINOPIMELATE
AMINOTRANSFERASE


(Salmonella
enterica)
PF00202
(Aminotran_3)
3 ALA A 115
THR A 252
PHE A 147
None
0.68A 2c6nB-2pb0A:
undetectable
2c6nB-2pb0A:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pcq PUTATIVE
DIHYDRODIPICOLINATE
SYNTHASE


(Thermus
thermophilus)
PF00701
(DHDPS)
3 ALA A 184
THR A 175
PHE A 211
None
0.61A 2c6nB-2pcqA:
undetectable
2c6nB-2pcqA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2var FRUCTOKINASE

(Sulfolobus
solfataricus)
PF00294
(PfkB)
3 ALA A 284
THR A 263
PHE A 307
None
0.72A 2c6nB-2varA:
undetectable
2c6nB-2varA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE


(Clostridium
perfringens)
PF00754
(F5_F8_type_C)
PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C)
3 ALA A 722
THR A 772
PHE A 704
None
0.75A 2c6nB-2vcaA:
0.1
2c6nB-2vcaA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vn7 GLUCOAMYLASE

(Trichoderma
reesei)
PF00686
(CBM_20)
PF00723
(Glyco_hydro_15)
3 ALA A 190
THR A 259
PHE A 227
None
0.72A 2c6nB-2vn7A:
undetectable
2c6nB-2vn7A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wpg AMYLOSUCRASE OR
ALPHA AMYLASE


(Xanthomonas
campestris)
PF00128
(Alpha-amylase)
PF11941
(DUF3459)
3 ALA A 322
THR A 283
PHE A 335
None
0.70A 2c6nB-2wpgA:
undetectable
2c6nB-2wpgA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x50 TRYPANOTHIONE
REDUCTASE


(Leishmania
infantum)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
3 ALA A 324
THR A 329
PHE A 345
None
0.78A 2c6nB-2x50A:
undetectable
2c6nB-2x50A:
22.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyd ANGIOTENSIN-CONVERTI
NG ENZYME


(Homo sapiens)
PF01401
(Peptidase_M2)
3 ALA A 332
THR A 358
PHE A 490
3ES  A1611 (-4.3A)
3ES  A1611 (-3.6A)
3ES  A1611 (-4.7A)
0.24A 2c6nB-2xydA:
56.3
2c6nB-2xydA:
98.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yln PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID


(Neisseria
gonorrhoeae)
PF00497
(SBP_bac_3)
3 ALA A 113
THR A  79
PHE A 109
None
0.76A 2c6nB-2ylnA:
undetectable
2c6nB-2ylnA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z37 CHITINASE

(Brassica juncea)
PF00182
(Glyco_hydro_19)
3 ALA A 300
THR A 209
PHE A 186
None
0.60A 2c6nB-2z37A:
undetectable
2c6nB-2z37A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zci PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]


(Corynebacterium
glutamicum)
PF00821
(PEPCK_C)
PF17297
(PEPCK_N)
3 ALA A 332
THR A 324
PHE A 317
None
0.61A 2c6nB-2zciA:
undetectable
2c6nB-2zciA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE


(Streptomyces
avermitilis)
PF00652
(Ricin_B_lectin)
PF16499
(Melibiase_2)
3 ALA A 462
THR A  48
PHE A 487
None
0.73A 2c6nB-3a21A:
undetectable
2c6nB-3a21A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a74 LYSYL-TRNA
SYNTHETASE


(Geobacillus
stearothermophilus)
PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
3 ALA A 413
THR A 284
PHE A 406
None
0.78A 2c6nB-3a74A:
undetectable
2c6nB-3a74A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ab4 ASPARTOKINASE

(Corynebacterium
glutamicum)
PF00696
(AA_kinase)
PF01842
(ACT)
PF13840
(ACT_7)
3 ALA A 222
THR B   7
PHE A 198
None
0.57A 2c6nB-3ab4A:
undetectable
2c6nB-3ab4A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cql ENDOCHITINASE

(Carica papaya)
PF00182
(Glyco_hydro_19)
3 ALA A 154
THR A  64
PHE A  41
None
0.58A 2c6nB-3cqlA:
undetectable
2c6nB-3cqlA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cze SUCROSE HYDROLASE

(Xanthomonas
citri)
PF00128
(Alpha-amylase)
3 ALA A 321
THR A 282
PHE A 334
None
0.71A 2c6nB-3czeA:
undetectable
2c6nB-3czeA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egi TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG


(Homo sapiens)
PF09445
(Methyltransf_15)
3 ALA A 682
THR A 711
PHE A 761
None
0.72A 2c6nB-3egiA:
undetectable
2c6nB-3egiA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdh TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG


(Homo sapiens)
PF09445
(Methyltransf_15)
3 ALA A 682
THR A 711
PHE A 761
None
0.63A 2c6nB-3gdhA:
undetectable
2c6nB-3gdhA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hym CELL DIVISION CYCLE
PROTEIN 16 HOMOLOG


(Homo sapiens)
PF13424
(TPR_12)
3 ALA B 412
THR B 420
PHE B 391
None
0.63A 2c6nB-3hymB:
undetectable
2c6nB-3hymB:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipi GERANYLTRANSTRANSFER
ASE


(Methanosarcina
mazei)
PF00348
(polyprenyl_synt)
3 ALA A  75
THR A 189
PHE A 140
None
0.78A 2c6nB-3ipiA:
1.4
2c6nB-3ipiA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwr CHITINASE

(Oryza sativa)
PF00182
(Glyco_hydro_19)
3 ALA A 241
THR A 151
PHE A 128
None
0.56A 2c6nB-3iwrA:
undetectable
2c6nB-3iwrA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE


(Cupriavidus
pinatubonensis)
PF00465
(Fe-ADH)
3 ALA A 306
THR A 261
PHE A 210
None
0.50A 2c6nB-3jzdA:
undetectable
2c6nB-3jzdA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7q PUTATIVE TRANSLATION
INITIATION
INHIBITOR, ALDR
REGULATOR-LIKE
PROTEIN


(Streptococcus
mutans)
PF01042
(Ribonuc_L-PSP)
3 ALA A 122
THR A  66
PHE A  27
None
0.78A 2c6nB-3l7qA:
undetectable
2c6nB-3l7qA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lr1 TUNGSTATE ABC
TRANSPORTER,
PERIPLASMIC
TUNGSTATE-BINDING
PROTEIN


(Geobacter
sulfurreducens)
PF12849
(PBP_like_2)
3 ALA A  43
THR A   9
PHE A  66
None
W  A 234 ( 4.0A)
None
0.77A 2c6nB-3lr1A:
undetectable
2c6nB-3lr1A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n5m ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE


(Bacillus
anthracis)
PF00202
(Aminotran_3)
3 ALA A 120
THR A 278
PHE A 139
None
0.50A 2c6nB-3n5mA:
undetectable
2c6nB-3n5mA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens)
PF00069
(Pkinase)
3 ALA A 309
THR A 182
PHE A 301
None
None
SO4  A   1 ( 4.9A)
0.79A 2c6nB-3nuuA:
undetectable
2c6nB-3nuuA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nx3 ACETYLORNITHINE
AMINOTRANSFERASE


(Campylobacter
jejuni)
PF00202
(Aminotran_3)
3 ALA A 109
THR A 245
PHE A 127
None
0.59A 2c6nB-3nx3A:
undetectable
2c6nB-3nx3A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p91 PROLIFERATING CELL
NUCLEAR ANTIGEN


(Entamoeba
histolytica)
PF00705
(PCNA_N)
PF02747
(PCNA_C)
3 ALA A 216
THR A 149
PHE A 248
None
0.74A 2c6nB-3p91A:
undetectable
2c6nB-3p91A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p9n POSSIBLE
METHYLTRANSFERASE
(METHYLASE)


(Mycobacterium
tuberculosis)
PF03602
(Cons_hypoth95)
3 ALA A  56
THR A   2
PHE A  33
None
0.66A 2c6nB-3p9nA:
undetectable
2c6nB-3p9nA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qlt GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 2


(Rattus
norvegicus)
PF01094
(ANF_receptor)
3 ALA A 295
THR A 101
PHE A   7
None
0.58A 2c6nB-3qltA:
undetectable
2c6nB-3qltA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tcq MATRIX PROTEIN VP40

(Sudan
ebolavirus)
PF07447
(VP40)
3 ALA A  70
THR A 190
PHE A  73
None
0.60A 2c6nB-3tcqA:
undetectable
2c6nB-3tcqA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqu NON-CANONICAL PURINE
NTP PYROPHOSPHATASE


(Coxiella
burnetii)
PF01725
(Ham1p_like)
3 ALA A  65
THR A  61
PHE A  28
None
0.77A 2c6nB-3tquA:
undetectable
2c6nB-3tquA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ty4 PROBABLE
HOMOISOCITRATE
DEHYDROGENASE


(Schizosaccharomyces
pombe)
PF00180
(Iso_dh)
3 ALA A  25
THR A 305
PHE A  42
None
0.74A 2c6nB-3ty4A:
undetectable
2c6nB-3ty4A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w3e COTYLEDONEOUS
YIELDIN-LIKE PROTEIN


(Vigna
unguiculata)
PF00182
(Glyco_hydro_19)
3 ALA A 153
THR A  65
PHE A  42
None
0.55A 2c6nB-3w3eA:
undetectable
2c6nB-3w3eA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuc CELLULOSOMAL
SCAFFOLDIN


(Acetivibrio
cellulolyticus)
PF00942
(CBM_3)
3 ALA A 130
THR A 134
PHE A 126
None
0.72A 2c6nB-3zucA:
undetectable
2c6nB-3zucA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5a NUCLEOSIDE-TRIPHOSPH
ATASE 1


(Toxoplasma
gondii)
PF01150
(GDA1_CD39)
3 ALA A 497
THR A 564
PHE A 525
None
0.68A 2c6nB-4a5aA:
undetectable
2c6nB-4a5aA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ade SUCCINYLORNITHINE
TRANSAMINASE


(Escherichia
coli)
PF00202
(Aminotran_3)
3 ALA A 112
THR A 249
PHE A 144
None
0.67A 2c6nB-4adeA:
undetectable
2c6nB-4adeA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bvt CYANURIC ACID
AMIDOHYDROLASE


(Pseudomonas sp.
ADP)
PF09663
(Amido_AtzD_TrzD)
3 ALA A  55
THR A  41
PHE A  80
None
0.66A 2c6nB-4bvtA:
undetectable
2c6nB-4bvtA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e5k PHOSPHITE
DEHYDROGENASE
(THERMOSTABLE
VARIANT)


(Pseudomonas
stutzeri)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
3 ALA A 159
THR A 101
PHE A 150
None
NAD  A 401 ( 4.8A)
None
0.63A 2c6nB-4e5kA:
undetectable
2c6nB-4e5kA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f92 U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE


(Homo sapiens)
PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63)
3 ALA B1497
THR B1511
PHE B1759
None
0.78A 2c6nB-4f92B:
undetectable
2c6nB-4f92B:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iss ALLOPHANATE
HYDROLASE


(Kluyveromyces
lactis)
PF01425
(Amidase)
3 ALA A 155
THR A 140
PHE A 215
None
0.72A 2c6nB-4issA:
undetectable
2c6nB-4issA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iu2 CELL-WALL ANCHORING
PROTEIN
CELLULOSE-BINDING
PROTEIN


(Ruminococcus
flavefaciens)
PF00963
(Cohesin)
no annotation
3 ALA A  67
THR B 137
PHE A 160
None
0.63A 2c6nB-4iu2A:
undetectable
2c6nB-4iu2A:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4krf PROTEIN ARGONAUTE-1

(Homo sapiens)
PF02170
(PAZ)
PF02171
(Piwi)
PF08699
(ArgoL1)
PF16486
(ArgoN)
PF16487
(ArgoMid)
PF16488
(ArgoL2)
3 ALA A 219
THR A 366
PHE A 222
A  R   7 ( 3.6A)
A  R   7 ( 3.5A)
None
0.67A 2c6nB-4krfA:
undetectable
2c6nB-4krfA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ld8 MATRIX PROTEIN VP40

(Sudan
ebolavirus)
PF07447
(VP40)
3 ALA A  70
THR A 190
PHE A  73
None
0.58A 2c6nB-4ld8A:
undetectable
2c6nB-4ld8A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ni2 GUANYLATE CYCLASE
SOLUBLE SUBUNIT
BETA-1


(Homo sapiens)
PF00211
(Guanylate_cyc)
3 ALA B 493
THR B 525
PHE B 582
None
0.75A 2c6nB-4ni2B:
undetectable
2c6nB-4ni2B:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]


(Rattus
norvegicus)
PF00821
(PEPCK_C)
PF17297
(PEPCK_N)
3 ALA A 347
THR A 339
PHE A 332
None
0.59A 2c6nB-4ox2A:
undetectable
2c6nB-4ox2A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlz SJCHGC07024 PROTEIN

(Schistosoma
japonicum)
PF00719
(Pyrophosphatase)
3 ALA A 259
THR A 243
PHE A  16
None
0.76A 2c6nB-4qlzA:
undetectable
2c6nB-4qlzA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qo1 NB139 NANOBODY
AGAINST THE
DNA-BINDING DOMAIN
OF P53


(Lama glama)
PF07686
(V-set)
3 ALA A  50
THR A  69
PHE A  38
None
0.70A 2c6nB-4qo1A:
undetectable
2c6nB-4qo1A:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tx7 CLASS I CHITINASE

(Vigna
unguiculata)
PF00182
(Glyco_hydro_19)
3 ALA A 198
THR A 109
PHE A  86
None
0.64A 2c6nB-4tx7A:
undetectable
2c6nB-4tx7A:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj0 CRISPR-ASSOCIATED
ENDONUCLEASE CAS1


(Pyrococcus
horikoshii)
PF01867
(Cas_Cas1)
3 ALA A 302
THR A 204
PHE A 231
None
0.71A 2c6nB-4wj0A:
undetectable
2c6nB-4wj0A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yx7 OXYGEN-REGULATED
INVASION PROTEIN
ORGB,ENDOLYSIN


(Escherichia
virus T4;
Salmonella
enterica)
PF00959
(Phage_lysozyme)
3 ALA C 193
THR C 184
PHE C  32
None
0.78A 2c6nB-4yx7C:
undetectable
2c6nB-4yx7C:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z81 EGF FAMILY
DOMAIN-CONTAINING
PROTEIN


(Toxoplasma
gondii)
PF02430
(AMA-1)
PF07974
(EGF_2)
3 ALA A 366
THR A 361
PHE A 351
None
0.79A 2c6nB-4z81A:
undetectable
2c6nB-4z81A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5afo FIMBRIAE

(Escherichia
coli)
PF00419
(Fimbrial)
3 ALA A 250
THR A 305
PHE A 349
None
0.57A 2c6nB-5afoA:
undetectable
2c6nB-5afoA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aov GLYOXYLATE REDUCTASE

(Pyrococcus
furiosus)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
3 ALA A 164
THR A 101
PHE A 158
1PE  A1346 ( 4.7A)
1PE  A1346 ( 4.7A)
None
0.76A 2c6nB-5aovA:
undetectable
2c6nB-5aovA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bu6 BPSB (PGAB),
POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE


(Bordetella
bronchiseptica)
PF01522
(Polysacc_deac_1)
3 ALA A 174
THR A 241
PHE A 124
None
0.72A 2c6nB-5bu6A:
undetectable
2c6nB-5bu6A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d1r RV1816
TRANSCRIPTIONAL
REGULATOR


(Mycobacterium
tuberculosis)
PF00440
(TetR_N)
3 ALA A  97
THR A  86
PHE A 142
None
None
56S  A 305 (-4.1A)
0.53A 2c6nB-5d1rA:
undetectable
2c6nB-5d1rA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dqp EDTA MONOOXYGENASE

(EDTA-degrading
bacterium BNC1)
PF00296
(Bac_luciferase)
3 ALA A 150
THR A 126
PHE A 226
None
0.73A 2c6nB-5dqpA:
undetectable
2c6nB-5dqpA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eks 3-DEHYDROQUINATE
SYNTHASE


(Acinetobacter
baumannii)
PF01761
(DHQ_synthase)
3 ALA A 275
THR A 292
PHE A 248
None
0.54A 2c6nB-5eksA:
undetectable
2c6nB-5eksA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f8p ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO


(Homo sapiens)
PF12933
(FTO_NTD)
PF12934
(FTO_CTD)
3 ALA A  68
THR A 138
PHE A 317
None
0.73A 2c6nB-5f8pA:
undetectable
2c6nB-5f8pA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fp1 TONB-DEPENDENT
SIDEROPHORE RECEPTOR


(Acinetobacter
baumannii)
PF00593
(TonB_dep_Rec)
PF07715
(Plug)
3 ALA A  71
THR A 700
PHE A  83
None
0.68A 2c6nB-5fp1A:
undetectable
2c6nB-5fp1A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis)
PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
3 ALA A 155
THR A 140
PHE A 215
None
0.70A 2c6nB-5i8iA:
undetectable
2c6nB-5i8iA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6b ALDEHYDE
DEHYDROGENASE


(Burkholderia
thailandensis)
PF00171
(Aldedh)
3 ALA A 165
THR A 108
PHE A 149
None
0.76A 2c6nB-5j6bA:
undetectable
2c6nB-5j6bA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jry NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE


(Burkholderia
multivorans)
PF00171
(Aldedh)
3 ALA A 165
THR A 108
PHE A 149
None
0.79A 2c6nB-5jryA:
undetectable
2c6nB-5jryA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ofk GLYCOSIDE HYDROLASE
FAMILY 48


(Caldicellulosiruptor
bescii)
PF00331
(Glyco_hydro_10)
3 ALA A  21
THR A 295
PHE A  73
None
0.77A 2c6nB-5ofkA:
undetectable
2c6nB-5ofkA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vba LYSOZYME, ESX-1
SECRETION-ASSOCIATED
PROTEIN ESPG1
CHIMERA


(Escherichia
virus T4;
Mycobacterium
kansasii)
PF00959
(Phage_lysozyme)
PF14011
(ESX-1_EspG)
3 ALA A1160
THR A1151
PHE A 999
None
0.76A 2c6nB-5vbaA:
undetectable
2c6nB-5vbaA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bii GLYOXYLATE REDUCTASE

(Pyrococcus
yayanosii)
no annotation 3 ALA A 164
THR A 101
PHE A 158
None
0.65A 2c6nB-6biiA:
undetectable
2c6nB-6biiA:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ces RAS-RELATED
GTP-BINDING PROTEIN
A


(Homo sapiens)
no annotation 3 ALA A 172
THR A 162
PHE A 123
None
0.73A 2c6nB-6cesA:
undetectable
2c6nB-6cesA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhv GLUCOAMYLASE

(Penicillium
oxalicum)
no annotation 3 ALA A 224
THR A 291
PHE A 261
None
0.76A 2c6nB-6fhvA:
undetectable
2c6nB-6fhvA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fik POLYKETIDE SYNTHASE

(Cercospora
nicotianae)
no annotation 3 ALA A 127
THR A 144
PHE A  96
None
0.72A 2c6nB-6fikA:
undetectable
2c6nB-6fikA:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fik POLYKETIDE SYNTHASE

(Cercospora
nicotianae)
no annotation 3 ALA A 454
THR A 838
PHE A 451
None
0.69A 2c6nB-6fikA:
undetectable
2c6nB-6fikA:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g5i RNA-BINDING PROTEIN
PNO1


(Homo sapiens)
no annotation 3 ALA x 221
THR x 200
PHE x 163
None
0.77A 2c6nB-6g5ix:
undetectable
2c6nB-6g5ix:
9.36