SIMILAR PATTERNS OF AMINO ACIDS FOR 2C6N_B_LPRB705_2
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1aw9 | GLUTATHIONES-TRANSFERASE III (Zea mays) |
PF00043(GST_C)PF02798(GST_N) | 3 | ALA A 170THR A 20PHE A 107 | None | 0.78A | 2c6nB-1aw9A:0.0 | 2c6nB-1aw9A:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cns | CHITINASE (Hordeum vulgare) |
PF00182(Glyco_hydro_19) | 3 | ALA A 154THR A 64PHE A 41 | None | 0.64A | 2c6nB-1cnsA:0.0 | 2c6nB-1cnsA:18.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dxj | CLASS II CHITINASE (Canavaliaensiformis) |
PF00182(Glyco_hydro_19) | 3 | ALA A 153THR A 65PHE A 42 | None | 0.67A | 2c6nB-1dxjA:0.0 | 2c6nB-1dxjA:17.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gdh | D-GLYCERATEDEHYDROGENASE (Hyphomicrobiummethylovorum) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C) | 3 | ALA A 161THR A 102PHE A 155 | NoneSO4 A 322 (-3.7A)None | 0.78A | 2c6nB-1gdhA:0.0 | 2c6nB-1gdhA:20.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ka9 | IMIDAZOLE GLYCEROLPHOSPHATE SYNTHASE (Thermusthermophilus) |
PF00977(His_biosynth) | 3 | ALA F 201THR F 188PHE F 211 | None | 0.77A | 2c6nB-1ka9F:0.0 | 2c6nB-1ka9F:17.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n7r | HYALURONIDASE (Streptococcuspneumoniae) |
PF02278(Lyase_8)PF02884(Lyase_8_C)PF08124(Lyase_8_N) | 3 | ALA A 653THR A 553PHE A 671 | None | 0.65A | 2c6nB-1n7rA:0.3 | 2c6nB-1n7rA:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ohf | NUDAURELIA CAPENSISOMEGA VIRUS CAPSIDPROTEIN (Nudaureliacapensis omegavirus) |
PF03566(Peptidase_A21) | 3 | ALA A 163THR A 522PHE A 165 | None | 0.70A | 2c6nB-1ohfA:0.0 | 2c6nB-1ohfA:22.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r47 | ALPHA-GALACTOSIDASEA (Homo sapiens) |
PF16499(Melibiase_2)PF17450(Melibiase_2_C) | 3 | ALA A 156THR A 194PHE A 169 | None | 0.71A | 2c6nB-1r47A:0.0 | 2c6nB-1r47A:21.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uan | HYPOTHETICAL PROTEINTT1542 (Thermusthermophilus) |
PF02585(PIG-L) | 3 | ALA A 25THR A 32PHE A 162 | None | 0.74A | 2c6nB-1uanA:undetectable | 2c6nB-1uanA:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ulq | PUTATIVE ACETYL-COAACETYLTRANSFERASE (Thermusthermophilus) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 3 | ALA A 327THR A 246PHE A 184 | None | 0.76A | 2c6nB-1ulqA:undetectable | 2c6nB-1ulqA:20.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v5b | 3-ISOPROPYLMALATEDEHYDROGENASE (Bacilluscoagulans) |
PF00180(Iso_dh) | 3 | ALA A 21THR A 296PHE A 38 | None | 0.78A | 2c6nB-1v5bA:undetectable | 2c6nB-1v5bA:20.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v93 | 5,10-METHYLENETETRAHYDROFOLATE REDUCTASE (Thermusthermophilus) |
PF02219(MTHFR) | 3 | ALA A 279THR A 212PHE A 271 | NoneNoneDIO A 301 (-4.9A) | 0.79A | 2c6nB-1v93A:undetectable | 2c6nB-1v93A:21.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vef | ACETYLORNITHINE/ACETYL-LYSINEAMINOTRANSFERASE (Thermusthermophilus) |
PF00202(Aminotran_3) | 3 | ALA A 120THR A 251PHE A 133 | None | 0.67A | 2c6nB-1vefA:undetectable | 2c6nB-1vefA:21.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wdw | TRYPTOPHAN SYNTHASEALPHA CHAIN (Pyrococcusfuriosus) |
PF00290(Trp_syntA) | 3 | ALA A 27THR A 235PHE A 75 | None | 0.71A | 2c6nB-1wdwA:undetectable | 2c6nB-1wdwA:17.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wye | 2-KETO-3-DEOXYGLUCONATE KINASE (Sulfurisphaeratokodaii) |
PF00294(PfkB) | 3 | ALA A 282THR A 261PHE A 305 | None | 0.66A | 2c6nB-1wyeA:undetectable | 2c6nB-1wyeA:18.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xr4 | PUTATIVE CITRATELYASE ALPHACHAIN/CITRATE-ACPTRANSFERASE (Salmonellaenterica) |
PF04223(CitF) | 3 | ALA A 277THR A 406PHE A 284 | None | 0.77A | 2c6nB-1xr4A:undetectable | 2c6nB-1xr4A:21.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y7e | PROBABLE M18-FAMILYAMINOPEPTIDASE 1 (Borreliellaburgdorferi) |
PF02127(Peptidase_M18) | 3 | ALA A 448THR A 262PHE A 443 | None | 0.76A | 2c6nB-1y7eA:undetectable | 2c6nB-1y7eA:20.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ykg | SULFITE REDUCTASE[NADPH] FLAVOPROTEINALPHA-COMPONENT (Escherichiacoli) |
PF00258(Flavodoxin_1) | 3 | ALA A 127THR A 115PHE A 102 | None | 0.75A | 2c6nB-1ykgA:undetectable | 2c6nB-1ykgA:15.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z9f | SINGLE-STRANDBINDING PROTEIN (Thermotogamaritima) |
PF00436(SSB) | 3 | ALA A 65THR A 57PHE A 106 | None | 0.63A | 2c6nB-1z9fA:undetectable | 2c6nB-1z9fA:12.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cas | CANINE PARVOVIRUSEMPTY CAPSID (STRAIND) VIRAL PROTEIN 2 (Carnivoreprotoparvovirus1) |
PF00740(Parvo_coat) | 3 | ALA A 188THR A 206PHE A 185 | None | 0.74A | 2c6nB-2casA:undetectable | 2c6nB-2casA:22.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cqy | PROPIONYL-COACARBOXYLASE ALPHACHAIN, MITOCHONDRIAL (Homo sapiens) |
PF02786(CPSase_L_D2) | 3 | ALA A 37THR A 70PHE A 27 | None | 0.69A | 2c6nB-2cqyA:undetectable | 2c6nB-2cqyA:11.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f9y | ACETYL-COENZYME ACARBOXYLASE CARBOXYLTRANSFERASE SUBUNITBETA (Escherichiacoli) |
PF01039(Carboxyl_trans) | 3 | ALA B 211THR B 202PHE B 142 | None | 0.79A | 2c6nB-2f9yB:undetectable | 2c6nB-2f9yB:18.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2faf | PHOSPHOENOLPYRUVATECARBOXYKINASE (Gallus gallus) |
PF00821(PEPCK_C)PF17297(PEPCK_N) | 3 | ALA A 366THR A 358PHE A 351 | None | 0.61A | 2c6nB-2fafA:undetectable | 2c6nB-2fafA:21.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hay | PUTATIVENAD(P)H-FLAVINOXIDOREDUCTASE (Streptococcuspyogenes) |
PF00881(Nitroreductase) | 3 | ALA A 38THR A 155PHE A 53 | None | 0.77A | 2c6nB-2hayA:undetectable | 2c6nB-2hayA:17.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hrz | NUCLEOSIDE-DIPHOSPHATE-SUGAR EPIMERASE (Agrobacteriumfabrum) |
PF01370(Epimerase) | 3 | ALA A 164THR A 153PHE A 132 | None | 0.71A | 2c6nB-2hrzA:undetectable | 2c6nB-2hrzA:20.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j3r | ZGC 92866 (Danio rerio) |
PF04051(TRAPP) | 3 | ALA B 140THR B 168PHE B 33 | NO3 B1177 (-3.1A)NO3 B1177 ( 3.7A)None | 0.78A | 2c6nB-2j3rB:undetectable | 2c6nB-2j3rB:14.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jb1 | L-AMINO ACID OXIDASE (Rhodococcusopacus) |
PF01593(Amino_oxidase) | 3 | ALA A 23THR A 292PHE A 246 | FAD A1489 (-3.2A)FAD A1489 ( 4.7A)None | 0.79A | 2c6nB-2jb1A:undetectable | 2c6nB-2jb1A:20.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nyf | NOSTOC PUNCTIFORMEPHENYLALANINEAMMONIA LYASE (Nostocpunctiforme) |
PF00221(Lyase_aromatic) | 3 | ALA A 251THR A 508PHE A 264 | None | 0.71A | 2c6nB-2nyfA:0.0 | 2c6nB-2nyfA:23.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2or2 | 1-PHOSPHATIDYLINOSITOL PHOSPHODIESTERASE (Bacillusthuringiensis) |
PF00388(PI-PLC-X) | 3 | ALA A 63THR A 31PHE A 101 | None | 0.60A | 2c6nB-2or2A:undetectable | 2c6nB-2or2A:18.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pb0 | ACETYLORNITHINE/SUCCINYLDIAMINOPIMELATEAMINOTRANSFERASE (Salmonellaenterica) |
PF00202(Aminotran_3) | 3 | ALA A 115THR A 252PHE A 147 | None | 0.68A | 2c6nB-2pb0A:undetectable | 2c6nB-2pb0A:19.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pcq | PUTATIVEDIHYDRODIPICOLINATESYNTHASE (Thermusthermophilus) |
PF00701(DHDPS) | 3 | ALA A 184THR A 175PHE A 211 | None | 0.61A | 2c6nB-2pcqA:undetectable | 2c6nB-2pcqA:20.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2var | FRUCTOKINASE (Sulfolobussolfataricus) |
PF00294(PfkB) | 3 | ALA A 284THR A 263PHE A 307 | None | 0.72A | 2c6nB-2varA:undetectable | 2c6nB-2varA:20.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vca | ALPHA-N-ACETYLGLUCOSAMINIDASE (Clostridiumperfringens) |
PF00754(F5_F8_type_C)PF05089(NAGLU)PF12971(NAGLU_N)PF12972(NAGLU_C) | 3 | ALA A 722THR A 772PHE A 704 | None | 0.75A | 2c6nB-2vcaA:0.1 | 2c6nB-2vcaA:19.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vn7 | GLUCOAMYLASE (Trichodermareesei) |
PF00686(CBM_20)PF00723(Glyco_hydro_15) | 3 | ALA A 190THR A 259PHE A 227 | None | 0.72A | 2c6nB-2vn7A:undetectable | 2c6nB-2vn7A:21.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wpg | AMYLOSUCRASE ORALPHA AMYLASE (Xanthomonascampestris) |
PF00128(Alpha-amylase)PF11941(DUF3459) | 3 | ALA A 322THR A 283PHE A 335 | None | 0.70A | 2c6nB-2wpgA:undetectable | 2c6nB-2wpgA:23.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x50 | TRYPANOTHIONEREDUCTASE (Leishmaniainfantum) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 3 | ALA A 324THR A 329PHE A 345 | None | 0.78A | 2c6nB-2x50A:undetectable | 2c6nB-2x50A:22.53 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2xyd | ANGIOTENSIN-CONVERTING ENZYME (Homo sapiens) |
PF01401(Peptidase_M2) | 3 | ALA A 332THR A 358PHE A 490 | 3ES A1611 (-4.3A)3ES A1611 (-3.6A)3ES A1611 (-4.7A) | 0.24A | 2c6nB-2xydA:56.3 | 2c6nB-2xydA:98.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yln | PUTATIVE ABCTRANSPORTER,PERIPLASMIC BINDINGPROTEIN, AMINO ACID (Neisseriagonorrhoeae) |
PF00497(SBP_bac_3) | 3 | ALA A 113THR A 79PHE A 109 | None | 0.76A | 2c6nB-2ylnA:undetectable | 2c6nB-2ylnA:18.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z37 | CHITINASE (Brassica juncea) |
PF00182(Glyco_hydro_19) | 3 | ALA A 300THR A 209PHE A 186 | None | 0.60A | 2c6nB-2z37A:undetectable | 2c6nB-2z37A:16.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zci | PHOSPHOENOLPYRUVATECARBOXYKINASE [GTP] (Corynebacteriumglutamicum) |
PF00821(PEPCK_C)PF17297(PEPCK_N) | 3 | ALA A 332THR A 324PHE A 317 | None | 0.61A | 2c6nB-2zciA:undetectable | 2c6nB-2zciA:23.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a21 | PUTATIVE SECRETEDALPHA-GALACTOSIDASE (Streptomycesavermitilis) |
PF00652(Ricin_B_lectin)PF16499(Melibiase_2) | 3 | ALA A 462THR A 48PHE A 487 | None | 0.73A | 2c6nB-3a21A:undetectable | 2c6nB-3a21A:21.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a74 | LYSYL-TRNASYNTHETASE (Geobacillusstearothermophilus) |
PF00152(tRNA-synt_2)PF01336(tRNA_anti-codon) | 3 | ALA A 413THR A 284PHE A 406 | None | 0.78A | 2c6nB-3a74A:undetectable | 2c6nB-3a74A:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ab4 | ASPARTOKINASE (Corynebacteriumglutamicum) |
PF00696(AA_kinase)PF01842(ACT)PF13840(ACT_7) | 3 | ALA A 222THR B 7PHE A 198 | None | 0.57A | 2c6nB-3ab4A:undetectable | 2c6nB-3ab4A:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cql | ENDOCHITINASE (Carica papaya) |
PF00182(Glyco_hydro_19) | 3 | ALA A 154THR A 64PHE A 41 | None | 0.58A | 2c6nB-3cqlA:undetectable | 2c6nB-3cqlA:16.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cze | SUCROSE HYDROLASE (Xanthomonascitri) |
PF00128(Alpha-amylase) | 3 | ALA A 321THR A 282PHE A 334 | None | 0.71A | 2c6nB-3czeA:undetectable | 2c6nB-3czeA:23.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3egi | TRIMETHYLGUANOSINESYNTHASE HOMOLOG (Homo sapiens) |
PF09445(Methyltransf_15) | 3 | ALA A 682THR A 711PHE A 761 | None | 0.72A | 2c6nB-3egiA:undetectable | 2c6nB-3egiA:16.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gdh | TRIMETHYLGUANOSINESYNTHASE HOMOLOG (Homo sapiens) |
PF09445(Methyltransf_15) | 3 | ALA A 682THR A 711PHE A 761 | None | 0.63A | 2c6nB-3gdhA:undetectable | 2c6nB-3gdhA:16.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hym | CELL DIVISION CYCLEPROTEIN 16 HOMOLOG (Homo sapiens) |
PF13424(TPR_12) | 3 | ALA B 412THR B 420PHE B 391 | None | 0.63A | 2c6nB-3hymB:undetectable | 2c6nB-3hymB:19.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ipi | GERANYLTRANSTRANSFERASE (Methanosarcinamazei) |
PF00348(polyprenyl_synt) | 3 | ALA A 75THR A 189PHE A 140 | None | 0.78A | 2c6nB-3ipiA:1.4 | 2c6nB-3ipiA:19.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iwr | CHITINASE (Oryza sativa) |
PF00182(Glyco_hydro_19) | 3 | ALA A 241THR A 151PHE A 128 | None | 0.56A | 2c6nB-3iwrA:undetectable | 2c6nB-3iwrA:19.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jzd | IRON-CONTAININGALCOHOLDEHYDROGENASE (Cupriaviduspinatubonensis) |
PF00465(Fe-ADH) | 3 | ALA A 306THR A 261PHE A 210 | None | 0.50A | 2c6nB-3jzdA:undetectable | 2c6nB-3jzdA:20.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l7q | PUTATIVE TRANSLATIONINITIATIONINHIBITOR, ALDRREGULATOR-LIKEPROTEIN (Streptococcusmutans) |
PF01042(Ribonuc_L-PSP) | 3 | ALA A 122THR A 66PHE A 27 | None | 0.78A | 2c6nB-3l7qA:undetectable | 2c6nB-3l7qA:11.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lr1 | TUNGSTATE ABCTRANSPORTER,PERIPLASMICTUNGSTATE-BINDINGPROTEIN (Geobactersulfurreducens) |
PF12849(PBP_like_2) | 3 | ALA A 43THR A 9PHE A 66 | None W A 234 ( 4.0A)None | 0.77A | 2c6nB-3lr1A:undetectable | 2c6nB-3lr1A:16.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n5m | ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE (Bacillusanthracis) |
PF00202(Aminotran_3) | 3 | ALA A 120THR A 278PHE A 139 | None | 0.50A | 2c6nB-3n5mA:undetectable | 2c6nB-3n5mA:22.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nuu | PKB-LIKE (Homo sapiens) |
PF00069(Pkinase) | 3 | ALA A 309THR A 182PHE A 301 | NoneNoneSO4 A 1 ( 4.9A) | 0.79A | 2c6nB-3nuuA:undetectable | 2c6nB-3nuuA:21.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nx3 | ACETYLORNITHINEAMINOTRANSFERASE (Campylobacterjejuni) |
PF00202(Aminotran_3) | 3 | ALA A 109THR A 245PHE A 127 | None | 0.59A | 2c6nB-3nx3A:undetectable | 2c6nB-3nx3A:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p91 | PROLIFERATING CELLNUCLEAR ANTIGEN (Entamoebahistolytica) |
PF00705(PCNA_N)PF02747(PCNA_C) | 3 | ALA A 216THR A 149PHE A 248 | None | 0.74A | 2c6nB-3p91A:undetectable | 2c6nB-3p91A:16.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p9n | POSSIBLEMETHYLTRANSFERASE(METHYLASE) (Mycobacteriumtuberculosis) |
PF03602(Cons_hypoth95) | 3 | ALA A 56THR A 2PHE A 33 | None | 0.66A | 2c6nB-3p9nA:undetectable | 2c6nB-3p9nA:17.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qlt | GLUTAMATE RECEPTOR,IONOTROPIC KAINATE 2 (Rattusnorvegicus) |
PF01094(ANF_receptor) | 3 | ALA A 295THR A 101PHE A 7 | None | 0.58A | 2c6nB-3qltA:undetectable | 2c6nB-3qltA:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tcq | MATRIX PROTEIN VP40 (Sudanebolavirus) |
PF07447(VP40) | 3 | ALA A 70THR A 190PHE A 73 | None | 0.60A | 2c6nB-3tcqA:undetectable | 2c6nB-3tcqA:19.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tqu | NON-CANONICAL PURINENTP PYROPHOSPHATASE (Coxiellaburnetii) |
PF01725(Ham1p_like) | 3 | ALA A 65THR A 61PHE A 28 | None | 0.77A | 2c6nB-3tquA:undetectable | 2c6nB-3tquA:16.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ty4 | PROBABLEHOMOISOCITRATEDEHYDROGENASE (Schizosaccharomycespombe) |
PF00180(Iso_dh) | 3 | ALA A 25THR A 305PHE A 42 | None | 0.74A | 2c6nB-3ty4A:undetectable | 2c6nB-3ty4A:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w3e | COTYLEDONEOUSYIELDIN-LIKE PROTEIN (Vignaunguiculata) |
PF00182(Glyco_hydro_19) | 3 | ALA A 153THR A 65PHE A 42 | None | 0.55A | 2c6nB-3w3eA:undetectable | 2c6nB-3w3eA:17.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zuc | CELLULOSOMALSCAFFOLDIN (Acetivibriocellulolyticus) |
PF00942(CBM_3) | 3 | ALA A 130THR A 134PHE A 126 | None | 0.72A | 2c6nB-3zucA:undetectable | 2c6nB-3zucA:14.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a5a | NUCLEOSIDE-TRIPHOSPHATASE 1 (Toxoplasmagondii) |
PF01150(GDA1_CD39) | 3 | ALA A 497THR A 564PHE A 525 | None | 0.68A | 2c6nB-4a5aA:undetectable | 2c6nB-4a5aA:21.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ade | SUCCINYLORNITHINETRANSAMINASE (Escherichiacoli) |
PF00202(Aminotran_3) | 3 | ALA A 112THR A 249PHE A 144 | None | 0.67A | 2c6nB-4adeA:undetectable | 2c6nB-4adeA:20.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bvt | CYANURIC ACIDAMIDOHYDROLASE (Pseudomonas sp.ADP) |
PF09663(Amido_AtzD_TrzD) | 3 | ALA A 55THR A 41PHE A 80 | None | 0.66A | 2c6nB-4bvtA:undetectable | 2c6nB-4bvtA:19.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e5k | PHOSPHITEDEHYDROGENASE(THERMOSTABLEVARIANT) (Pseudomonasstutzeri) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C) | 3 | ALA A 159THR A 101PHE A 150 | NoneNAD A 401 ( 4.8A)None | 0.63A | 2c6nB-4e5kA:undetectable | 2c6nB-4e5kA:20.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f92 | U5 SMALL NUCLEARRIBONUCLEOPROTEIN200 KDA HELICASE (Homo sapiens) |
PF00270(DEAD)PF00271(Helicase_C)PF02889(Sec63) | 3 | ALA B1497THR B1511PHE B1759 | None | 0.78A | 2c6nB-4f92B:undetectable | 2c6nB-4f92B:15.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iss | ALLOPHANATEHYDROLASE (Kluyveromyceslactis) |
PF01425(Amidase) | 3 | ALA A 155THR A 140PHE A 215 | None | 0.72A | 2c6nB-4issA:undetectable | 2c6nB-4issA:22.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iu2 | CELL-WALL ANCHORINGPROTEINCELLULOSE-BINDINGPROTEIN (Ruminococcusflavefaciens) |
PF00963(Cohesin)no annotation | 3 | ALA A 67THR B 137PHE A 160 | None | 0.63A | 2c6nB-4iu2A:undetectable | 2c6nB-4iu2A:16.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4krf | PROTEIN ARGONAUTE-1 (Homo sapiens) |
PF02170(PAZ)PF02171(Piwi)PF08699(ArgoL1)PF16486(ArgoN)PF16487(ArgoMid)PF16488(ArgoL2) | 3 | ALA A 219THR A 366PHE A 222 | A R 7 ( 3.6A) A R 7 ( 3.5A)None | 0.67A | 2c6nB-4krfA:undetectable | 2c6nB-4krfA:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ld8 | MATRIX PROTEIN VP40 (Sudanebolavirus) |
PF07447(VP40) | 3 | ALA A 70THR A 190PHE A 73 | None | 0.58A | 2c6nB-4ld8A:undetectable | 2c6nB-4ld8A:17.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ni2 | GUANYLATE CYCLASESOLUBLE SUBUNITBETA-1 (Homo sapiens) |
PF00211(Guanylate_cyc) | 3 | ALA B 493THR B 525PHE B 582 | None | 0.75A | 2c6nB-4ni2B:undetectable | 2c6nB-4ni2B:16.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ox2 | PHOSPHOENOLPYRUVATECARBOXYKINASE,CYTOSOLIC [GTP] (Rattusnorvegicus) |
PF00821(PEPCK_C)PF17297(PEPCK_N) | 3 | ALA A 347THR A 339PHE A 332 | None | 0.59A | 2c6nB-4ox2A:undetectable | 2c6nB-4ox2A:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qlz | SJCHGC07024 PROTEIN (Schistosomajaponicum) |
PF00719(Pyrophosphatase) | 3 | ALA A 259THR A 243PHE A 16 | None | 0.76A | 2c6nB-4qlzA:undetectable | 2c6nB-4qlzA:17.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qo1 | NB139 NANOBODYAGAINST THEDNA-BINDING DOMAINOF P53 (Lama glama) |
PF07686(V-set) | 3 | ALA A 50THR A 69PHE A 38 | None | 0.70A | 2c6nB-4qo1A:undetectable | 2c6nB-4qo1A:14.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tx7 | CLASS I CHITINASE (Vignaunguiculata) |
PF00182(Glyco_hydro_19) | 3 | ALA A 198THR A 109PHE A 86 | None | 0.64A | 2c6nB-4tx7A:undetectable | 2c6nB-4tx7A:16.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wj0 | CRISPR-ASSOCIATEDENDONUCLEASE CAS1 (Pyrococcushorikoshii) |
PF01867(Cas_Cas1) | 3 | ALA A 302THR A 204PHE A 231 | None | 0.71A | 2c6nB-4wj0A:undetectable | 2c6nB-4wj0A:20.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yx7 | OXYGEN-REGULATEDINVASION PROTEINORGB,ENDOLYSIN (Escherichiavirus T4;Salmonellaenterica) |
PF00959(Phage_lysozyme) | 3 | ALA C 193THR C 184PHE C 32 | None | 0.78A | 2c6nB-4yx7C:undetectable | 2c6nB-4yx7C:16.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z81 | EGF FAMILYDOMAIN-CONTAININGPROTEIN (Toxoplasmagondii) |
PF02430(AMA-1)PF07974(EGF_2) | 3 | ALA A 366THR A 361PHE A 351 | None | 0.79A | 2c6nB-4z81A:undetectable | 2c6nB-4z81A:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5afo | FIMBRIAE (Escherichiacoli) |
PF00419(Fimbrial) | 3 | ALA A 250THR A 305PHE A 349 | None | 0.57A | 2c6nB-5afoA:undetectable | 2c6nB-5afoA:20.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5aov | GLYOXYLATE REDUCTASE (Pyrococcusfuriosus) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C) | 3 | ALA A 164THR A 101PHE A 158 | 1PE A1346 ( 4.7A)1PE A1346 ( 4.7A)None | 0.76A | 2c6nB-5aovA:undetectable | 2c6nB-5aovA:20.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bu6 | BPSB (PGAB),POLY-BETA-1,6-N-ACETYL-D-GLUCOSAMINEN-DEACETYLASE (Bordetellabronchiseptica) |
PF01522(Polysacc_deac_1) | 3 | ALA A 174THR A 241PHE A 124 | None | 0.72A | 2c6nB-5bu6A:undetectable | 2c6nB-5bu6A:20.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d1r | RV1816TRANSCRIPTIONALREGULATOR (Mycobacteriumtuberculosis) |
PF00440(TetR_N) | 3 | ALA A 97THR A 86PHE A 142 | NoneNone56S A 305 (-4.1A) | 0.53A | 2c6nB-5d1rA:undetectable | 2c6nB-5d1rA:18.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dqp | EDTA MONOOXYGENASE (EDTA-degradingbacterium BNC1) |
PF00296(Bac_luciferase) | 3 | ALA A 150THR A 126PHE A 226 | None | 0.73A | 2c6nB-5dqpA:undetectable | 2c6nB-5dqpA:23.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eks | 3-DEHYDROQUINATESYNTHASE (Acinetobacterbaumannii) |
PF01761(DHQ_synthase) | 3 | ALA A 275THR A 292PHE A 248 | None | 0.54A | 2c6nB-5eksA:undetectable | 2c6nB-5eksA:20.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f8p | ALPHA-KETOGLUTARATE-DEPENDENTDIOXYGENASE FTO (Homo sapiens) |
PF12933(FTO_NTD)PF12934(FTO_CTD) | 3 | ALA A 68THR A 138PHE A 317 | None | 0.73A | 2c6nB-5f8pA:undetectable | 2c6nB-5f8pA:23.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fp1 | TONB-DEPENDENTSIDEROPHORE RECEPTOR (Acinetobacterbaumannii) |
PF00593(TonB_dep_Rec)PF07715(Plug) | 3 | ALA A 71THR A 700PHE A 83 | None | 0.68A | 2c6nB-5fp1A:undetectable | 2c6nB-5fp1A:23.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i8i | UREA AMIDOLYASE (Kluyveromyceslactis) |
PF00289(Biotin_carb_N)PF01425(Amidase)PF02626(CT_A_B)PF02682(CT_C_D)PF02785(Biotin_carb_C)PF02786(CPSase_L_D2) | 3 | ALA A 155THR A 140PHE A 215 | None | 0.70A | 2c6nB-5i8iA:undetectable | 2c6nB-5i8iA:17.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j6b | ALDEHYDEDEHYDROGENASE (Burkholderiathailandensis) |
PF00171(Aldedh) | 3 | ALA A 165THR A 108PHE A 149 | None | 0.76A | 2c6nB-5j6bA:undetectable | 2c6nB-5j6bA:22.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jry | NAD-DEPENDENTALDEHYDEDEHYDROGENASE (Burkholderiamultivorans) |
PF00171(Aldedh) | 3 | ALA A 165THR A 108PHE A 149 | None | 0.79A | 2c6nB-5jryA:undetectable | 2c6nB-5jryA:21.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ofk | GLYCOSIDE HYDROLASEFAMILY 48 (Caldicellulosiruptorbescii) |
PF00331(Glyco_hydro_10) | 3 | ALA A 21THR A 295PHE A 73 | None | 0.77A | 2c6nB-5ofkA:undetectable | 2c6nB-5ofkA:18.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vba | LYSOZYME, ESX-1SECRETION-ASSOCIATEDPROTEIN ESPG1CHIMERA (Escherichiavirus T4;Mycobacteriumkansasii) |
PF00959(Phage_lysozyme)PF14011(ESX-1_EspG) | 3 | ALA A1160THR A1151PHE A 999 | None | 0.76A | 2c6nB-5vbaA:undetectable | 2c6nB-5vbaA:21.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bii | GLYOXYLATE REDUCTASE (Pyrococcusyayanosii) |
no annotation | 3 | ALA A 164THR A 101PHE A 158 | None | 0.65A | 2c6nB-6biiA:undetectable | 2c6nB-6biiA:8.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ces | RAS-RELATEDGTP-BINDING PROTEINA (Homo sapiens) |
no annotation | 3 | ALA A 172THR A 162PHE A 123 | None | 0.73A | 2c6nB-6cesA:undetectable | 2c6nB-6cesA:8.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fhv | GLUCOAMYLASE (Penicilliumoxalicum) |
no annotation | 3 | ALA A 224THR A 291PHE A 261 | None | 0.76A | 2c6nB-6fhvA:undetectable | 2c6nB-6fhvA:10.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fik | POLYKETIDE SYNTHASE (Cercosporanicotianae) |
no annotation | 3 | ALA A 127THR A 144PHE A 96 | None | 0.72A | 2c6nB-6fikA:undetectable | 2c6nB-6fikA:10.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fik | POLYKETIDE SYNTHASE (Cercosporanicotianae) |
no annotation | 3 | ALA A 454THR A 838PHE A 451 | None | 0.69A | 2c6nB-6fikA:undetectable | 2c6nB-6fikA:10.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6g5i | RNA-BINDING PROTEINPNO1 (Homo sapiens) |
no annotation | 3 | ALA x 221THR x 200PHE x 163 | None | 0.77A | 2c6nB-6g5ix:undetectable | 2c6nB-6g5ix:9.36 |