SIMILAR PATTERNS OF AMINO ACIDS FOR 2C49_B_ADNB1301
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dgm | ADENOSINE KINASE (Toxoplasmagondii) |
PF00294(PfkB) | 4 | ASP A 24GLY A 68GLY A 69ASN A 73 | ADN A 375 (-2.9A)ADN A 375 ( 4.5A)ADN A 375 (-2.9A)ADN A 375 ( 4.9A) | 0.48A | 2c49B-1dgmA:29.8 | 2c49B-1dgmA:25.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fbw | ENDO-1,4-BETA-GLUCANASE F ([Clostridium]cellulolyticum) |
PF02011(Glyco_hydro_48) | 4 | ALA A 166ASP A 169GLY A 165ASN A 160 | None | 0.75A | 2c49B-1fbwA:undetectable | 2c49B-1fbwA:18.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h3g | CYCLOMALTODEXTRINASE (Flavobacteriumsp. 92) |
PF00128(Alpha-amylase)PF09087(Cyc-maltodext_N)PF10438(Cyc-maltodext_C) | 4 | ALA A 118GLY A 120GLY A 149PHE A 485 | None | 0.65A | 2c49B-1h3gA:undetectable | 2c49B-1h3gA:18.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1id0 | PHOQ HISTIDINEKINASE (Escherichiacoli) |
PF02518(HATPase_c) | 4 | ALA A 470ASP A 415GLY A 469GLY A 419 | ANP A 487 (-3.5A)ANP A 487 (-3.7A)NoneANP A 487 (-4.3A) | 0.78A | 2c49B-1id0A:undetectable | 2c49B-1id0A:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l5j | ACONITATE HYDRATASE2 (Escherichiacoli) |
PF00330(Aconitase)PF06434(Aconitase_2_N)PF11791(Aconitase_B_N) | 4 | ALA A 429GLY A 95GLY A 96ASN A 98 | None | 0.65A | 2c49B-1l5jA:undetectable | 2c49B-1l5jA:16.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pgp | 6-PHOSPHOGLUCONATEDEHYDROGENASE (Ovis aries) |
PF00393(6PGD)PF03446(NAD_binding_2) | 4 | ALA A 358GLY A 356GLY A 355ASN A 353 | None | 0.70A | 2c49B-1pgpA:4.2 | 2c49B-1pgpA:22.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r4n | AMYLOID BETAPRECURSORPROTEIN-BINDINGPROTEIN 1UBIQUITIN-ACTIVATINGENZYME E1C (Homo sapiens) |
PF00899(ThiF)PF08825(E2_bind) | 5 | ALA A 500GLY A 498GLY A 499ASN A 48PHE B 324 | None | 1.24A | 2c49B-1r4nA:2.1 | 2c49B-1r4nA:20.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rk2 | RIBOKINASE (Escherichiacoli) |
PF00294(PfkB) | 4 | ASP A 16GLY A 41GLY A 42ASN A 46 | RIB A 311 (-2.8A)RIB A 311 (-3.3A)RIB A 311 (-3.4A)RIB A 311 (-3.3A) | 0.41A | 2c49B-1rk2A:34.5 | 2c49B-1rk2A:24.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tyd | TYROSYL-TRNASYNTHETASE (Geobacillusstearothermophilus) |
PF00579(tRNA-synt_1b) | 4 | ASP E 38GLY E 70GLY E 71ASN E 123 | TYR E 320 (-3.6A)TYR E 320 ( 4.9A)NoneTYR E 320 ( 4.7A) | 0.74A | 2c49B-1tydE:undetectable | 2c49B-1tydE:22.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tz6 | PUTATIVE SUGARKINASE (Salmonellaenterica) |
PF00294(PfkB) | 4 | ASP A 16GLY A 30GLY A 31ASN A 35 | AIS A 402 (-2.5A)AIS A 402 ( 4.2A)AIS A 402 (-3.8A)AIS A 402 (-3.9A) | 0.56A | 2c49B-1tz6A:31.3 | 2c49B-1tz6A:24.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ulv | GLUCODEXTRANASE (Arthrobacterglobiformis) |
PF00723(Glyco_hydro_15)PF09136(Glucodextran_B)PF09137(Glucodextran_N)PF09985(Glucodextran_C) | 4 | ALA A 758ASP A 760GLY A 761GLY A 762 | None | 0.76A | 2c49B-1ulvA:undetectable | 2c49B-1ulvA:14.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vbm | TYROSYL-TRNASYNTHETASE (Escherichiacoli) |
PF00579(tRNA-synt_1b) | 4 | ASP A 41GLY A 73GLY A 74ASN A 126 | YSA A3001 (-3.9A)YSA A3001 ( 4.9A)NoneYSA A3001 ( 4.9A) | 0.76A | 2c49B-1vbmA:2.2 | 2c49B-1vbmA:23.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vm7 | RIBOKINASE (Thermotogamaritima) |
PF00294(PfkB) | 4 | ASP A 14GLY A 39GLY A 40ASN A 44 | None | 0.19A | 2c49B-1vm7A:36.6 | 2c49B-1vm7A:29.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ys5 | LIPOPROTEIN (Neisseriameningitidis) |
PF08794(Lipoprot_C) | 4 | HIS A 84ASP A 62GLY A 64GLY A 65 | None | 0.76A | 2c49B-1ys5A:undetectable | 2c49B-1ys5A:21.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zxn | DNA TOPOISOMERASEII, ALPHA ISOZYME (Homo sapiens) |
PF00204(DNA_gyraseB)PF02518(HATPase_c) | 5 | ASP A 327GLY A 323GLY A 322ASN A 380PHE A 308 | None | 0.96A | 2c49B-1zxnA:undetectable | 2c49B-1zxnA:23.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2abq | FRUCTOSE 1-PHOSPHATEKINASE (Bacillushalodurans) |
PF00294(PfkB) | 4 | ASP A 12GLY A 36GLY A 37ASN A 41 | None | 0.63A | 2c49B-2abqA:28.6 | 2c49B-2abqA:26.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ajr | SUGAR KINASE, PFKBFAMILY (Thermotogamaritima) |
PF00294(PfkB) | 5 | ALA A 10ASP A 12GLY A 39GLY A 40ASN A 44 | ACT A 321 ( 4.4A)ACT A 321 (-3.1A)ACT A 321 ( 4.3A)ACT A 321 (-3.9A)ACT A 321 (-3.9A) | 0.75A | 2c49B-2ajrA:25.2 | 2c49B-2ajrA:27.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bvg | 6-HYDROXY-D-NICOTINEOXIDASE (Paenarthrobacternicotinovorans) |
PF01565(FAD_binding_4)PF08031(BBE) | 5 | ALA A 154GLY A 142GLY A 143ASN A 413PHE A 135 | NoneNoneFAD A 600 (-3.0A)FAD A 600 (-3.8A)None | 1.42A | 2c49B-2bvgA:undetectable | 2c49B-2bvgA:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2epg | HYPOTHETICAL PROTEINTTHA1785 (Thermusthermophilus) |
PF01139(RtcB) | 5 | HIS A 328ALA A 348ASP A 64GLY A 74GLY A 347 | None | 1.48A | 2c49B-2epgA:undetectable | 2c49B-2epgA:23.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f7v | AECTYLCITRULLINEDEACETYLASE (Xanthomonascampestris) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 4 | ALA A 203GLY A 201GLY A 200PHE A 223 | None | 0.72A | 2c49B-2f7vA:undetectable | 2c49B-2f7vA:21.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fkk | BASEPLATE STRUCTURALPROTEIN GP10 (Escherichiavirus T4) |
no annotation | 4 | GLY A 518GLY A 517ASN A 502PHE A 481 | None | 0.74A | 2c49B-2fkkA:undetectable | 2c49B-2fkkA:23.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i6b | ADENOSINE KINASE (Homo sapiens) |
PF00294(PfkB) | 4 | ASP A 18GLY A 63GLY A 64ASN A 68 | NoneNone89I A 500 (-3.5A)None | 0.62A | 2c49B-2i6bA:25.9 | 2c49B-2i6bA:27.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jg5 | FRUCTOSE 1-PHOSPHATEKINASE (Staphylococcusaureus) |
PF00294(PfkB) | 4 | ASP A 12GLY A 36GLY A 37ASN A 41 | None | 0.60A | 2c49B-2jg5A:27.9 | 2c49B-2jg5A:26.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jwp | MALECTIN (Xenopus laevis) |
PF11721(Malectin) | 5 | ALA A 41ASP A 32GLY A 17GLY A 18ASN A 15 | None | 1.34A | 2c49B-2jwpA:undetectable | 2c49B-2jwpA:24.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nwh | CARBOHYDRATE KINASE (Agrobacteriumfabrum) |
PF00294(PfkB) | 4 | ASP A 13GLY A 37GLY A 38ASN A 42 | NoneNone CL A 403 (-3.5A)None | 0.26A | 2c49B-2nwhA:27.8 | 2c49B-2nwhA:23.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o4v | PORIN P (Pseudomonasaeruginosa) |
PF07396(Porin_O_P) | 4 | ALA A 268GLY A 270GLY A 196PHE A 319 | None | 0.76A | 2c49B-2o4vA:undetectable | 2c49B-2o4vA:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pid | TYROSYL-TRNASYNTHETASE (Homo sapiens) |
PF00579(tRNA-synt_1b) | 4 | ASP A 81GLY A 113GLY A 114ASN A 173 | YSA A 384 (-3.9A)YSA A 384 ( 4.6A)NoneYSA A 384 ( 4.8A) | 0.69A | 2c49B-2pidA:undetectable | 2c49B-2pidA:20.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qcv | PUTATIVE5-DEHYDRO-2-DEOXYGLUCONOKINASE (Bacillushalodurans) |
PF00294(PfkB) | 4 | ASP A 22GLY A 43GLY A 44ASN A 48 | None | 0.58A | 2c49B-2qcvA:31.2 | 2c49B-2qcvA:26.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qua | EXTRACELLULAR LIPASE (Serratiamarcescens) |
no annotation | 5 | ALA A 409GLY A 411GLY A 410ASN A 415PHE A 331 | None CA A 618 ( 4.2A) CA A 618 (-4.6A) CA A 618 (-2.8A)None | 1.34A | 2c49B-2quaA:undetectable | 2c49B-2quaA:20.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ts1 | TYROSYL-TRNASYNTHETASE (Geobacillusstearothermophilus) |
PF00579(tRNA-synt_1b) | 4 | ASP A 38GLY A 70GLY A 71ASN A 123 | None | 0.75A | 2c49B-2ts1A:undetectable | 2c49B-2ts1A:20.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vhd | CYTOCHROME C551PEROXIDASE (Pseudomonasaeruginosa) |
PF00034(Cytochrom_C)PF03150(CCP_MauG) | 4 | HIS A 55ALA A 62GLY A 60GLY A 61 | HEC A 401 (-3.3A)NoneNoneNone | 0.75A | 2c49B-2vhdA:undetectable | 2c49B-2vhdA:20.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xd3 | MALTOSE/MALTODEXTRIN-BINDING PROTEIN (Streptococcuspneumoniae) |
PF13416(SBP_bac_8) | 5 | ALA A 252ASP A 192GLY A 253GLY A 251PHE A 392 | GLC A1423 (-4.6A)GLC A1423 (-3.2A)GLC A1423 (-3.3A)GLC A1423 (-3.4A)None | 1.31A | 2c49B-2xd3A:undetectable | 2c49B-2xd3A:22.43 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3b1r | RIBOKINASE, PUTATIVE (Burkholderiathailandensis) |
PF00294(PfkB) | 6 | ALA A 10ASP A 12GLY A 47GLY A 48ASN A 52PHE A 117 | AMP A 501 (-3.4A)AMP A 501 (-2.9A)AMP A 501 ( 3.7A)AMP A 501 (-3.3A)AMP A 501 (-3.3A)AMP A 501 (-3.5A) | 0.47A | 2c49B-3b1rA:36.7 | 2c49B-3b1rA:30.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b3l | KETOHEXOKINASE (Homo sapiens) |
PF00294(PfkB) | 4 | ASP A 15GLY A 40GLY A 41ASN A 45 | None | 0.50A | 2c49B-3b3lA:28.6 | 2c49B-3b3lA:23.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bf5 | RIBOKINASE RELATEDPROTEIN (Thermoplasmaacidophilum) |
PF00294(PfkB) | 5 | HIS A 9ASP A 13GLY A 37GLY A 38ASN A 42 | PGO A 288 ( 4.9A)NoneNoneNoneNone | 0.72A | 2c49B-3bf5A:31.2 | 2c49B-3bf5A:27.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cgy | VIRULENCE SENSORHISTIDINE KINASEPHOQ (Salmonellaenterica) |
PF02518(HATPase_c) | 4 | ALA A 471ASP A 416GLY A 470GLY A 420 | RDC A 700 (-3.3A)RDC A 700 (-3.1A)NoneRDC A 700 (-4.1A) | 0.74A | 2c49B-3cgyA:undetectable | 2c49B-3cgyA:22.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cv2 | MALATE SYNTHASE A (Escherichiacoli) |
PF01274(Malate_synthase) | 4 | GLY A 329GLY A 328ASN A 273PHE A 379 | None | 0.72A | 2c49B-3cv2A:undetectable | 2c49B-3cv2A:20.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d1j | GLYCOGEN SYNTHASE (Escherichiacoli) |
PF00534(Glycos_transf_1)PF08323(Glyco_transf_5) | 4 | ALA A 402ASP A 403GLY A 400GLY A 399 | None | 0.75A | 2c49B-3d1jA:8.1 | 2c49B-3d1jA:19.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dm9 | SIGNAL RECOGNITIONPARTICLE RECEPTOR (Pyrococcusfuriosus) |
PF00448(SRP54)PF02881(SRP54_N) | 4 | ALA B 281GLY B 279GLY B 278PHE B 312 | None | 0.74A | 2c49B-3dm9B:2.3 | 2c49B-3dm9B:22.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ewm | UNCHARACTERIZEDSUGAR KINASE PH1459 (Pyrococcushorikoshii) |
PF00294(PfkB) | 4 | ASP A 13GLY A 33GLY A 34ASN A 38 | None | 0.38A | 2c49B-3ewmA:30.1 | 2c49B-3ewmA:29.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3go7 | RIBOKINASE RBSK (Mycobacteriumtuberculosis) |
PF00294(PfkB) | 4 | ASP A 25GLY A 50GLY A 51ASN A 55 | RIB A 305 (-2.8A)RIB A 305 ( 3.7A)RIB A 305 (-3.1A)RIB A 305 (-3.2A) | 0.51A | 2c49B-3go7A:31.2 | 2c49B-3go7A:23.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hj6 | FRUCTOKINASE (Halothermothrixorenii) |
PF00294(PfkB) | 4 | ASP A 33GLY A 54GLY A 55ASN A 59 | None | 0.29A | 2c49B-3hj6A:25.2 | 2c49B-3hj6A:25.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i3y | CARBOHYDRATE KINASE (Klebsiellapneumoniae) |
PF00294(PfkB) | 4 | ASP A 12GLY A 37GLY A 38ASN A 42 | None | 0.35A | 2c49B-3i3yA:30.7 | 2c49B-3i3yA:23.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3in1 | UNCHARACTERIZEDSUGAR KINASE YDJH (Escherichiacoli) |
PF00294(PfkB) | 4 | ASP A 15GLY A 41GLY A 42ASN A 46 | None | 0.36A | 2c49B-3in1A:33.4 | 2c49B-3in1A:25.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kd6 | CARBOHYDRATE KINASE,PFKB FAMILY (Chlorobaculumtepidum) |
PF00294(PfkB) | 4 | ALA A 10ASP A 12GLY A 26GLY A 27 | AMP A 509 ( 3.8A)AMP A 509 (-2.8A)AMP A 509 ( 3.8A)AMP A 509 (-3.4A) | 0.33A | 2c49B-3kd6A:29.4 | 2c49B-3kd6A:25.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3km5 | LYSINE SPECIFICCYSTEINE PROTEASE (Porphyromonasgingivalis) |
PF07675(Cleaved_Adhesin) | 4 | ALA A1200ASP A1326GLY A1202GLY A1203 | CA A2012 ( 4.3A) CA A2012 (-2.3A) CA A2012 (-4.1A) CA A2012 ( 4.6A) | 0.77A | 2c49B-3km5A:undetectable | 2c49B-3km5A:21.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kzh | PROBABLE SUGARKINASE (Clostridiumperfringens) |
PF00294(PfkB) | 4 | ASP A 18GLY A 42GLY A 43ASN A 47 | None | 0.71A | 2c49B-3kzhA:30.5 | 2c49B-3kzhA:25.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lki | FRUCTOKINASE (Xylellafastidiosa) |
PF00294(PfkB) | 4 | ASP A 24GLY A 44GLY A 45ASN A 49 | None | 0.46A | 2c49B-3lkiA:24.8 | 2c49B-3lkiA:22.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3loo | ANOPHELES GAMBIAEADENOSINE KINASE (Anophelesgambiae) |
PF00294(PfkB) | 4 | ASP A 18GLY A 63GLY A 64ASN A 68 | B4P A 349 (-2.8A)B4P A 349 ( 3.8A)B4P A 349 (-3.5A)B4P A 349 (-3.6A) | 0.45A | 2c49B-3looA:27.0 | 2c49B-3looA:24.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3os7 | GALACTOSEMUTAROTASE-LIKEPROTEIN (Clostridiumacetobutylicum) |
PF01263(Aldose_epim) | 4 | HIS A 184ALA A 186GLY A 72ASN A 38 | TLA A 401 (-3.9A)NoneNoneNone | 0.75A | 2c49B-3os7A:undetectable | 2c49B-3os7A:22.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3otx | ADENOSINE KINASE,PUTATIVE (Trypanosomabrucei) |
PF00294(PfkB) | 4 | ASP A 17GLY A 62GLY A 63ASN A 67 | AP5 A 346 (-2.8A)AP5 A 346 (-3.6A)AP5 A 346 (-3.5A)AP5 A 346 (-3.4A) | 0.49A | 2c49B-3otxA:27.3 | 2c49B-3otxA:25.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p5m | ENOYL-COAHYDRATASE/ISOMERASE (Mycobacteriumavium) |
PF00378(ECH_1) | 5 | ALA A 136GLY A 135GLY A 134ASN A 78PHE A 125 | None | 1.11A | 2c49B-3p5mA:undetectable | 2c49B-3p5mA:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pl2 | SUGAR KINASE,RIBOKINASE FAMILY (Corynebacteriumglutamicum) |
PF00294(PfkB) | 5 | ASP A 19GLY A 40GLY A 41ASN A 45PHE A 111 | None | 0.91A | 2c49B-3pl2A:29.9 | 2c49B-3pl2A:29.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pyg | 4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL KINASE (Mycobacteriumtuberculosis) |
PF00288(GHMP_kinases_N)PF08544(GHMP_kinases_C) | 4 | ALA A 108ASP A 109GLY A 106GLY A 105 | NoneNoneADP A 307 (-3.2A)ADP A 307 (-3.3A) | 0.70A | 2c49B-3pygA:undetectable | 2c49B-3pygA:22.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q1y | LIN2199 PROTEIN (Listeriainnocua) |
PF00294(PfkB) | 4 | ALA A 10ASP A 12GLY A 37GLY A 38 | None | 0.73A | 2c49B-3q1yA:26.6 | 2c49B-3q1yA:24.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ro3 | G-PROTEIN-SIGNALINGMODULATOR 2 (Mus musculus) |
PF13424(TPR_12) | 5 | HIS A 205ALA A 217GLY A 199GLY A 202ASN A 203 | None | 1.36A | 2c49B-3ro3A:undetectable | 2c49B-3ro3A:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ry7 | RIBOKINASE (Staphylococcusaureus) |
PF00294(PfkB) | 4 | ASP A 14GLY A 40GLY A 41ASN A 45 | GOL A 401 (-3.1A)GOL A 401 ( 3.7A)GOL A 401 (-3.8A)GOL A 401 (-3.9A) | 0.35A | 2c49B-3ry7A:29.7 | 2c49B-3ry7A:25.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ubm | FORMYL-COA:OXALATECOA-TRANSFERASE (Acetobacteraceti) |
PF02515(CoA_transf_3) | 4 | ASP A 18GLY A 20GLY A 21ASN A 102 | NoneNoneNoneCOA A2001 (-4.0A) | 0.67A | 2c49B-3ubmA:2.6 | 2c49B-3ubmA:22.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ubo | ADENOSINE KINASE (Sinorhizobiummeliloti) |
PF00294(PfkB) | 4 | ASP A 15GLY A 58GLY A 59ASN A 63 | ADN A 353 (-2.8A)ADN A 353 (-3.3A)ADN A 353 (-3.2A)ADN A 353 (-3.4A) | 0.35A | 2c49B-3uboA:29.7 | 2c49B-3uboA:25.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ucg | POLYADENYLATE-BINDING PROTEIN 2 (Homo sapiens) |
PF00076(RRM_1) | 4 | ALA A 183ASP A 180GLY A 182PHE A 237 | None | 0.74A | 2c49B-3ucgA:undetectable | 2c49B-3ucgA:16.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uqe | 6-PHOSPHOFRUCTOKINASE ISOZYME 2 (Escherichiacoli) |
PF00294(PfkB) | 4 | ASP A 14GLY A 38GLY A 39ASN A 43 | None | 0.61A | 2c49B-3uqeA:28.0 | 2c49B-3uqeA:22.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vas | PUTATIVE ADENOSINEKINASE (Schistosomamansoni) |
PF00294(PfkB) | 4 | ASP A 18GLY A 63GLY A 64ASN A 68 | ADN A 401 (-2.7A)ADN A 401 ( 3.8A)ADN A 401 (-3.7A)ADN A 401 (-3.7A) | 0.47A | 2c49B-3vasA:27.7 | 2c49B-3vasA:25.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vpi | TYPE VI SECRETIONEXPORTED 1 (Pseudomonasaeruginosa) |
no annotation | 4 | HIS A 91GLY A 86GLY A 90ASN A 51 | None | 0.77A | 2c49B-3vpiA:undetectable | 2c49B-3vpiA:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w1h | L-SERYL-TRNA(SEC)SELENIUM TRANSFERASE (Aquifexaeolicus) |
PF03841(SelA) | 5 | HIS A 215ALA A 248GLY A 281GLY A 249ASN A 142 | NoneNoneNoneLLP A 285 ( 3.0A)LLP A 285 ( 4.5A) | 1.47A | 2c49B-3w1hA:undetectable | 2c49B-3w1hA:21.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e3a | SUGAR KINASE PROTEIN (Rhizobium etli) |
PF00294(PfkB) | 4 | ASP A 13GLY A 56GLY A 57ASN A 61 | ADN A 500 (-2.7A)ADN A 500 (-3.5A)ADN A 500 (-3.7A)ADN A 500 (-3.5A) | 0.42A | 2c49B-4e3aA:31.2 | 2c49B-4e3aA:25.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e79 | UDP-3-O-ACYLGLUCOSAMINEN-ACYLTRANSFERASE (Acinetobacterbaumannii) |
PF00132(Hexapep)PF04613(LpxD)PF14602(Hexapep_2) | 4 | HIS A 244ALA A 224GLY A 204GLY A 223 | None | 0.76A | 2c49B-4e79A:undetectable | 2c49B-4e79A:22.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eqa | PUTATIVEUNCHARACTERIZEDPROTEIN (Pseudomonasaeruginosa) |
no annotation | 4 | HIS A 91GLY A 86GLY A 90ASN A 51 | None | 0.76A | 2c49B-4eqaA:undetectable | 2c49B-4eqaA:18.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g8k | 2-5A-DEPENDENTRIBONUCLEASE (Homo sapiens) |
PF12796(Ank_2)PF13857(Ank_5) | 5 | ALA A 169GLY A 168GLY A 167ASN A 200PHE A 126 | None | 1.08A | 2c49B-4g8kA:undetectable | 2c49B-4g8kA:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gcz | BLUE-LIGHTPHOTORECEPTOR,SENSOR PROTEIN FIXL (Bacillussubtilis;Bradyrhizobiumdiazoefficiens) |
PF00512(HisKA)PF02518(HATPase_c)PF13426(PAS_9) | 5 | ALA A 363ASP A 310GLY A 312GLY A 314PHE A 365 | ADP A 402 (-3.3A)ADP A 402 (-3.6A)NoneADP A 402 (-3.9A)ADP A 402 (-4.6A) | 1.36A | 2c49B-4gczA:undetectable | 2c49B-4gczA:21.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gcz | BLUE-LIGHTPHOTORECEPTOR,SENSOR PROTEIN FIXL (Bacillussubtilis;Bradyrhizobiumdiazoefficiens) |
PF00512(HisKA)PF02518(HATPase_c)PF13426(PAS_9) | 5 | ALA A 363ASP A 310GLY A 362GLY A 314PHE A 365 | ADP A 402 (-3.3A)ADP A 402 (-3.6A)NoneADP A 402 (-3.9A)ADP A 402 (-4.6A) | 1.29A | 2c49B-4gczA:undetectable | 2c49B-4gczA:21.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4glp | MONOCYTEDIFFERENTIATIONANTIGEN CD14 (Homo sapiens) |
PF13516(LRR_6) | 4 | HIS A 60ALA A 98GLY A 63GLY A 62 | None | 0.73A | 2c49B-4glpA:undetectable | 2c49B-4glpA:20.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iss | ALLOPHANATEHYDROLASE (Kluyveromyceslactis) |
PF01425(Amidase) | 4 | ALA A 155ASP A 124GLY A 152GLY A 151 | None | 0.68A | 2c49B-4issA:undetectable | 2c49B-4issA:18.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jhr | G-PROTEIN-SIGNALINGMODULATOR 2 (Mus musculus) |
PF02188(GoLoco)PF13176(TPR_7)PF13424(TPR_12) | 5 | HIS A 205ALA A 217GLY A 199GLY A 202ASN A 203 | None | 1.37A | 2c49B-4jhrA:undetectable | 2c49B-4jhrA:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lgn | CELLULOSE-BINDING,FAMILY II (Acidothermuscellulolyticus) |
no annotation | 4 | ALA A 402GLY A 18GLY A 17PHE A 366 | None | 0.77A | 2c49B-4lgnA:undetectable | 2c49B-4lgnA:17.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o1o | RIBONUCLEASE L (Sus scrofa) |
PF00069(Pkinase)PF06479(Ribonuc_2-5A)PF12796(Ank_2)PF13857(Ank_5) | 5 | ALA A 167GLY A 166GLY A 165ASN A 198PHE A 124 | 25L A1000 ( 4.4A)None25L A1000 ( 4.3A)None25L A1000 (-3.5A) | 1.12A | 2c49B-4o1oA:undetectable | 2c49B-4o1oA:17.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oav | PROTEIN (RNASE L) (Homo sapiens) |
PF00069(Pkinase)PF06479(Ribonuc_2-5A)PF12796(Ank_2)PF13857(Ank_5) | 5 | ALA B 169GLY B 168GLY B 167ASN B 200PHE B 126 | A C 3 ( 4.6A)None A C 3 ( 4.4A)None A C 3 ( 3.6A) | 1.16A | 2c49B-4oavB:undetectable | 2c49B-4oavB:18.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ohj | TOXIC SHOCK SYNDROMETOXIN-1 (Staphylococcusaureus) |
PF02876(Stap_Strp_tox_C) | 4 | ASP A 207GLY A 192GLY A 191ASN A 234 | None | 0.74A | 2c49B-4ohjA:undetectable | 2c49B-4ohjA:24.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pvv | ADENOSINE KINASE (Mycobacteriumtuberculosis) |
PF00294(PfkB) | 6 | ALA A 10ASP A 12GLY A 47GLY A 48ASN A 52PHE A 116 | HO4 A 401 (-3.3A)HO4 A 401 (-2.4A)HO4 A 401 (-3.5A)HO4 A 401 (-3.5A)HO4 A 401 (-3.8A)HO4 A 401 (-3.6A) | 0.50A | 2c49B-4pvvA:35.1 | 2c49B-4pvvA:28.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qav | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 2 (Neisseriameningitidis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | HIS A 170ALA A 169GLY A 346GLY A 168PHE A 262 | None | 1.50A | 2c49B-4qavA:undetectable | 2c49B-4qavA:21.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rjw | PORIN O (Pseudomonasaeruginosa) |
PF07396(Porin_O_P) | 4 | ALA A 270GLY A 272GLY A 197PHE A 322 | None | 0.78A | 2c49B-4rjwA:undetectable | 2c49B-4rjwA:22.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wjm | RIBOKINASE:CARBOHYDRATE KINASE, PFKB (Brucellaabortus) |
PF00294(PfkB) | 5 | ASP A 11GLY A 29GLY A 30ASN A 34PHE A 98 | None | 0.63A | 2c49B-4wjmA:31.3 | 2c49B-4wjmA:24.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x8f | RIBOKINASE (Vibrio cholerae) |
PF00294(PfkB) | 4 | ASP A 13GLY A 38GLY A 39ASN A 43 | None | 0.31A | 2c49B-4x8fA:33.5 | 2c49B-4x8fA:25.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c41 | RIBOKINASE (Homo sapiens) |
PF00294(PfkB) | 4 | ASP A 27GLY A 52GLY A 53ASN A 57 | None | 0.36A | 2c49B-5c41A:33.3 | 2c49B-5c41A:25.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cc8 | THIAMINE-MONOPHOSPHATE KINASE (Acinetobacterbaumannii) |
PF00586(AIRS)PF02769(AIRS_C) | 4 | ALA A 162ASP A 249GLY A 247GLY A 246 | None | 0.72A | 2c49B-5cc8A:undetectable | 2c49B-5cc8A:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e3c | DIPEPTIDYL PEPTIDASE3 (Homo sapiens) |
PF03571(Peptidase_M49) | 4 | ALA A 47GLY A 45GLY A 44PHE A 314 | None | 0.71A | 2c49B-5e3cA:undetectable | 2c49B-5e3cA:20.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ey7 | FRUCTOKINASE (Vibrio cholerae) |
PF00294(PfkB) | 5 | ASP A 30GLY A 44GLY A 45ASN A 49PHE A 115 | None | 0.75A | 2c49B-5ey7A:32.1 | 2c49B-5ey7A:25.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i8i | UREA AMIDOLYASE (Kluyveromyceslactis) |
PF00289(Biotin_carb_N)PF01425(Amidase)PF02626(CT_A_B)PF02682(CT_C_D)PF02785(Biotin_carb_C)PF02786(CPSase_L_D2) | 4 | ALA A 155ASP A 124GLY A 152GLY A 151 | None | 0.71A | 2c49B-5i8iA:4.0 | 2c49B-5i8iA:10.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5idj | CELL CYCLE HISTIDINEKINASE CCKA (Caulobactervibrioides) |
PF00512(HisKA)PF02518(HATPase_c) | 5 | ALA A 534ASP A 479GLY A 481GLY A 483PHE A 536 | ADP A 600 (-3.4A)ADP A 600 (-3.3A)NoneADP A 600 ( 4.5A)ADP A 600 (-4.5A) | 1.42A | 2c49B-5idjA:undetectable | 2c49B-5idjA:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5idj | CELL CYCLE HISTIDINEKINASE CCKA (Caulobactervibrioides) |
PF00512(HisKA)PF02518(HATPase_c) | 5 | ALA A 534ASP A 479GLY A 533GLY A 483PHE A 536 | ADP A 600 (-3.4A)ADP A 600 (-3.3A)NoneADP A 600 ( 4.5A)ADP A 600 (-4.5A) | 1.32A | 2c49B-5idjA:undetectable | 2c49B-5idjA:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5idm | CELL CYCLE HISTIDINEKINASE CCKA (Caulobactervibrioides) |
PF02518(HATPase_c) | 5 | ALA A 534ASP A 479GLY A 481GLY A 483PHE A 536 | ANP A 601 ( 3.8A)ANP A 601 (-3.5A)NoneANP A 601 ( 4.5A)ANP A 601 ( 4.6A) | 1.33A | 2c49B-5idmA:undetectable | 2c49B-5idmA:20.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5idm | CELL CYCLE HISTIDINEKINASE CCKA (Caulobactervibrioides) |
PF02518(HATPase_c) | 5 | ALA A 534ASP A 479GLY A 533GLY A 483PHE A 536 | ANP A 601 ( 3.8A)ANP A 601 (-3.5A)NoneANP A 601 ( 4.5A)ANP A 601 ( 4.6A) | 1.30A | 2c49B-5idmA:undetectable | 2c49B-5idmA:20.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ijx | TYROSINE--TRNALIGASE,MITOCHONDRIAL (Coccidioidesposadasii) |
PF00579(tRNA-synt_1b) | 4 | ASP A 118GLY A 150GLY A 151ASN A 214 | TYR A 501 (-2.9A)TYR A 501 ( 3.8A)NoneTYR A 501 ( 4.4A) | 0.69A | 2c49B-5ijxA:undetectable | 2c49B-5ijxA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mrj | BETA-XYLANASE (Acremoniumchrysogenum) |
no annotation | 5 | HIS A 215ALA A 329GLY A 296ASN A 262PHE A 107 | None | 1.21A | 2c49B-5mrjA:undetectable | 2c49B-5mrjA:13.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tj3 | ALKALINE PHOSPHATASEPAFA (Elizabethkingiameningoseptica) |
PF01663(Phosphodiest) | 4 | ALA A 330ASP A 326GLY A 56GLY A 55 | None | 0.57A | 2c49B-5tj3A:undetectable | 2c49B-5tj3A:22.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5um6 | UBIQUITIN-ACTIVATINGENZYME E1 1 (Schizosaccharomycespombe) |
PF00899(ThiF)PF09358(E1_UFD)PF10585(UBA_e1_thiolCys)PF16190(E1_FCCH)PF16191(E1_4HB) | 5 | ALA A 364GLY A 362GLY A 363ASN A 55PHE A 895 | None | 1.41A | 2c49B-5um6A:3.7 | 2c49B-5um6A:15.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yal | ESTERASE (Streptomycescinnamoneus) |
no annotation | 4 | HIS A 268ALA A 235GLY A 266GLY A 267 | None | 0.63A | 2c49B-5yalA:4.0 | 2c49B-5yalA:13.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zu5 | ALGINATE LYASE (Vibriosplendidus) |
no annotation | 4 | ALA A 265ASP A 267GLY A 268GLY A 269 | None | 0.77A | 2c49B-5zu5A:undetectable | 2c49B-5zu5A:17.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cw5 | RIBOKINASE (Cryptococcusneoformans) |
no annotation | 4 | ASP A 16GLY A 41GLY A 42ASN A 46 | GOL A 400 (-2.8A)GOL A 400 (-3.5A)GOL A 400 (-3.3A)GOL A 400 (-3.3A) | 0.40A | 2c49B-6cw5A:32.3 | 2c49B-6cw5A:15.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6et9 | ACETYL-COAACETYLTRANSFERASETHIOLASE (Methanothermococcusthermolithotrophicus) |
no annotation | 5 | HIS A 171ALA A 170ASP A 285GLY A 330GLY A 329 | None | 1.43A | 2c49B-6et9A:undetectable | 2c49B-6et9A:13.85 |