SIMILAR PATTERNS OF AMINO ACIDS FOR 2C2B_F_SAMF501_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y3n ALGQ1

(Sphingomonas
sp. A1) 		PF01547
(SBP_bac_1) 		4 ASN A 278
ASN A 401
TRP A 399
TRP A 270
 None
None
None
BEM  A 494 ( 3.8A)
 1.11A 2c2bC-1y3nA:
0.0
2c2bE-1y3nA:
0.0
2c2bF-1y3nA:
0.0		 2c2bC-1y3nA:
20.53
2c2bE-1y3nA:
20.53
2c2bF-1y3nA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfw ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF00496
(SBP_bac_5) 		4 ASN A 527
TRP A 265
ASN A 530
TRP A 537
 None
 1.41A 2c2bC-4pfwA:
1.2
2c2bE-4pfwA:
0.0
2c2bF-4pfwA:
1.2		 2c2bC-4pfwA:
21.49
2c2bE-4pfwA:
21.49
2c2bF-4pfwA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jp0 BETA-GLUCOSIDASE
BOGH3B

(Bacteroides
ovatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 ASN A 538
TRP A 458
TRP A 454
TRP A 315
 None
 0.82A 2c2bC-5jp0A:
1.1
2c2bE-5jp0A:
1.1
2c2bF-5jp0A:
1.3		 2c2bC-5jp0A:
22.21
2c2bE-5jp0A:
22.21
2c2bF-5jp0A:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8o 5-NITROANTHRANILIC
ACID AMINOHYDROLASE

(Bradyrhizobium
sp.) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 ASN A  67
TRP A 132
ASN A  84
TRP A  48
 None
 1.40A 2c2bC-5k8oA:
0.0
2c2bE-5k8oA:
0.3
2c2bF-5k8oA:
0.2		 2c2bC-5k8oA:
22.94
2c2bE-5k8oA:
22.94
2c2bF-5k8oA:
22.94