SIMILAR PATTERNS OF AMINO ACIDS FOR 2C2B_E_SAME500
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1itx | GLYCOSYL HYDROLASE (Bacilluscirculans) |
PF00704(Glyco_hydro_18) | 5 | SER A 361TRP A 342GLY A 368SER A 369PHE A 370 | GOL A1004 ( 4.1A)NoneNoneNoneNone | 1.32A | 2c2bE-1itxA:0.82c2bF-1itxA:0.8 | 2c2bE-1itxA:22.932c2bF-1itxA:22.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1itx | GLYCOSYL HYDROLASE (Bacilluscirculans) |
PF00704(Glyco_hydro_18) | 5 | TRP A 342GLY A 368SER A 369PHE A 370LEU A 398 | None | 1.48A | 2c2bE-1itxA:0.82c2bF-1itxA:0.8 | 2c2bE-1itxA:22.932c2bF-1itxA:22.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a7m | N-ACYL HOMOSERINELACTONE HYDROLASE (Bacillusthuringiensis) |
PF00753(Lactamase_B) | 5 | GLY A 207SER A 23PHE A 205ASN A 198ASP A 108 | NoneNoneNoneNone ZN A 251 ( 2.7A) | 0.75A | 2c2bE-2a7mA:0.02c2bF-2a7mA:0.0 | 2c2bE-2a7mA:19.922c2bF-2a7mA:19.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bfu | COWPEA MOSAIC VIRUS,LARGE (L) SUBUNIT (Cowpea mosaicvirus) |
PF02247(Como_LCP) | 5 | SER L 237TRP L 308GLY L 356PHE L 354LEU L 193 | None | 1.38A | 2c2bE-2bfuL:0.02c2bF-2bfuL:undetectable | 2c2bE-2bfuL:21.582c2bF-2bfuL:21.58 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2c2g | THREONINE SYNTHASE (Arabidopsisthaliana) |
PF00291(PALP) | 5 | SER A 99TRP A 101GLY A 104SER A 105SER A 125 | None | 0.49A | 2c2bE-2c2gA:60.22c2bF-2c2gA:56.4 | 2c2bE-2c2gA:100.002c2bF-2c2gA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dck | XYLANASE J (Bacillus sp.41M-1) |
PF00457(Glyco_hydro_11)PF03422(CBM_6) | 5 | GLY A 25SER A 26PHE A 47LEU A 46ASP A 20 | None | 1.21A | 2c2bE-2dckA:0.02c2bF-2dckA:0.0 | 2c2bE-2dckA:22.332c2bF-2dckA:22.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f3o | PYRUVATEFORMATE-LYASE 2 (Archaeoglobusfulgidus) |
PF01228(Gly_radical)PF02901(PFL-like) | 5 | GLY A 142SER A 143PHE A 641GLN A 324ASP A 319 | None | 1.39A | 2c2bE-2f3oA:1.22c2bF-2f3oA:0.0 | 2c2bE-2f3oA:21.372c2bF-2f3oA:21.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x1f | MRNA3'-END-PROCESSINGPROTEIN RNA15 (Saccharomycescerevisiae) |
PF00076(RRM_1) | 5 | GLY A 42SER A 71PHE A 66LEU A 47ASP A 36 | None | 1.50A | 2c2bE-2x1fA:undetectable2c2bF-2x1fA:undetectable | 2c2bE-2x1fA:10.252c2bF-2x1fA:10.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ywr | PHOSPHORIBOSYLGLYCINAMIDEFORMYLTRANSFERASE (Aquifexaeolicus) |
PF00551(Formyl_trans_N) | 5 | SER A 9GLY A 12SER A 13LEU A 86ASP A 37 | None MG A 703 ( 3.9A) MG A 703 (-4.1A)NoneNone | 1.45A | 2c2bE-2ywrA:0.72c2bF-2ywrA:4.0 | 2c2bE-2ywrA:18.402c2bF-2ywrA:18.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zfu | CEREBRAL PROTEIN 1 (Homo sapiens) |
PF05148(Methyltransf_8) | 5 | SER A 263GLY A 261SER A 260LEU A 366ASP A 346 | SAH A 900 (-4.2A)NoneNoneNoneSAH A 900 (-3.6A) | 0.99A | 2c2bE-2zfuA:0.72c2bF-2zfuA:0.5 | 2c2bE-2zfuA:18.842c2bF-2zfuA:18.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3by9 | SENSOR PROTEIN (Vibrio cholerae) |
PF02743(dCache_1) | 5 | SER A 213TRP A 209SER A 204TRP A 252GLN A 199 | None | 1.40A | 2c2bE-3by9A:undetectable2c2bF-3by9A:undetectable | 2c2bE-3by9A:18.852c2bF-3by9A:18.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fd3 | CHROMOSOMEREPLICATIONINITIATION INHIBITORPROTEIN (Agrobacteriumfabrum) |
PF03466(LysR_substrate) | 5 | SER A 244PHE A 248ASN A 261LEU A 260GLN A 223 | None CA A 1 (-3.7A)NoneNoneNone | 1.42A | 2c2bE-3fd3A:undetectable2c2bF-3fd3A:undetectable | 2c2bE-3fd3A:18.552c2bF-3fd3A:18.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j3i | CAPSID PROTEIN (Penicilliumchrysogenumvirus) |
no annotation | 5 | SER A 650GLY A 648SER A 646LEU A 692GLN A 651 | None | 1.38A | 2c2bE-3j3iA:undetectable2c2bF-3j3iA:undetectable | 2c2bE-3j3iA:21.292c2bF-3j3iA:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ls2 | S-FORMYLGLUTATHIONEHYDROLASE (Pseudoalteromonashaloplanktis) |
PF00756(Esterase) | 5 | SER A 171GLY A 150SER A 202LEU A 250ASP A 225 | None | 1.12A | 2c2bE-3ls2A:undetectable2c2bF-3ls2A:1.2 | 2c2bE-3ls2A:19.382c2bF-3ls2A:19.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qyy | RESPONSE REGULATOR (Xanthomonascampestris) |
PF00990(GGDEF) | 5 | SER A 253GLY A 255SER A 256ASN A 234ASP A 175 | None | 0.98A | 2c2bE-3qyyA:undetectable2c2bF-3qyyA:undetectable | 2c2bE-3qyyA:16.522c2bF-3qyyA:16.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rh9 | SUCCINATE-SEMIALDEHYDE DEHYDROGENASE(NAD(P)(+)) (Marinobacterhydrocarbonoclasticus) |
PF00171(Aldedh) | 5 | SER A 176GLY A 56SER A 58LEU A 200TRP A 74 | None | 1.21A | 2c2bE-3rh9A:undetectable2c2bF-3rh9A:undetectable | 2c2bE-3rh9A:23.472c2bF-3rh9A:23.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zvk | TOXIN OFTOXIN-ANTITOXINSYSTEMANTITOXIN OFTOXIN-ANTITOXINSYSTEM VAPB (Rickettsiafelis;Rickettsiafelis) |
PF01850(PIN)PF04014(MazE_antitoxin) | 5 | SER A 59SER A 66SER E 29LEU E 33GLN A 58 | None | 1.39A | 2c2bE-3zvkA:undetectable2c2bF-3zvkA:3.1 | 2c2bE-3zvkA:12.882c2bF-3zvkA:12.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d8u | D-CYSTEINEDESULFHYDRASE (Salmonellaenterica) |
PF00291(PALP) | 5 | GLY A 160SER A 161SER A 195ASN A 50GLN A 83 | NoneLLP A 51 ( 3.4A)LLP A 51 ( 2.4A)LLP A 51 ( 3.1A)LLP A 51 ( 3.5A) | 1.22A | 2c2bE-4d8uA:23.32c2bF-4d8uA:24.8 | 2c2bE-4d8uA:20.902c2bF-4d8uA:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ds3 | PHOSPHORIBOSYLGLYCINAMIDEFORMYLTRANSFERASE (Brucellamelitensis) |
PF00551(Formyl_trans_N) | 5 | SER A 11GLY A 14SER A 15LEU A 88ASP A 39 | NoneGOL A 305 (-3.7A)GOL A 305 (-4.7A)NoneNone | 1.42A | 2c2bE-4ds3A:undetectable2c2bF-4ds3A:2.7 | 2c2bE-4ds3A:18.052c2bF-4ds3A:18.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ixl | XYLANASE (Bacillus sp.(in: Bacteria)) |
PF00457(Glyco_hydro_11) | 5 | GLY A 25SER A 26PHE A 47LEU A 46ASP A 20 | None | 1.21A | 2c2bE-4ixlA:undetectable2c2bF-4ixlA:undetectable | 2c2bE-4ixlA:17.542c2bF-4ixlA:17.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kca | ENDO-1,5-ALPHA-L-ARABINANASE (Bos taurus) |
PF00085(Thioredoxin)PF04616(Glyco_hydro_43)PF16369(GH43_C) | 5 | SER A 211GLY A 209SER A 208ASN A 239ASP A 213 | NoneNoneNoneIOD A 725 (-4.1A)None | 0.98A | 2c2bE-4kcaA:undetectable2c2bF-4kcaA:undetectable | 2c2bE-4kcaA:20.452c2bF-4kcaA:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nfu | SENESCENCE-ASSOCIATED CARBOXYLESTERASE101 (Arabidopsisthaliana) |
PF01764(Lipase_3) | 5 | SER B 71GLY B 148SER B 150SER B 177TRP B 26 | None | 1.34A | 2c2bE-4nfuB:undetectable2c2bF-4nfuB:undetectable | 2c2bE-4nfuB:21.032c2bF-4nfuB:21.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ovs | TRAP DICARBOXYLATETRANSPORTER, DCTPSUBUNIT (Sulfurospirillumdeleyianum) |
PF03480(DctP) | 5 | GLY A 233SER A 88SER A 90PHE A 89LEU A 101 | NoneSIN A 401 ( 3.5A)NoneNoneNone | 1.42A | 2c2bE-4ovsA:undetectable2c2bF-4ovsA:2.3 | 2c2bE-4ovsA:20.922c2bF-4ovsA:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p22 | UBIQUITIN-LIKEMODIFIER-ACTIVATINGENZYME 1 (Homo sapiens) |
PF00899(ThiF)PF16190(E1_FCCH)PF16191(E1_4HB) | 5 | SER A 114PHE A 116LEU A 118GLN A 115ASP A 393 | None | 1.46A | 2c2bE-4p22A:undetectable2c2bF-4p22A:undetectable | 2c2bE-4p22A:23.052c2bF-4p22A:23.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ubq | BETA-LACTAMASE (Acinetobacterbaumannii) |
no annotation | 5 | SER A 123GLY A 121SER A 120PHE A 119LEU A 126 | None | 1.24A | 2c2bE-4ubqA:undetectable2c2bF-4ubqA:undetectable | 2c2bE-4ubqA:17.522c2bF-4ubqA:17.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wwh | ABC TRANSPORTER (Mycolicibacteriumsmegmatis) |
PF13407(Peripla_BP_4) | 5 | GLY A 249SER A 251SER A 245LEU A 222ASP A 78 | None | 1.12A | 2c2bE-4wwhA:undetectable2c2bF-4wwhA:1.7 | 2c2bE-4wwhA:22.712c2bF-4wwhA:22.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z37 | PUTATIVE MIXEDPOLYKETIDESYNTHASE/NON-RIBOSOMAL PEPTIDESYNTHETASE (Brevibacillusbrevis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C)PF16197(KAsynt_C_assoc) | 5 | SER A2696GLY A2348SER A2347LEU A2693GLN A2716 | None | 0.93A | 2c2bE-4z37A:undetectable2c2bF-4z37A:1.6 | 2c2bE-4z37A:22.122c2bF-4z37A:22.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f2t | - (-) |
no annotation | 5 | SER A 380GLY A 480SER A 332SER A 336GLN A 466 | None | 1.50A | 2c2bE-6f2tA:undetectable2c2bF-6f2tA:undetectable | 2c2bE-6f2tA:undetectable2c2bF-6f2tA:undetectable |