SIMILAR PATTERNS OF AMINO ACIDS FOR 2C12_F_SPMF1433

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bjn PHOSPHOSERINE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00266
(Aminotran_5) 		5 GLN A  79
LEU A 231
VAL A  83
ALA A  82
LEU A  85
 None
 1.35A 2c12F-1bjnA:
0.0		 2c12F-1bjnA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dk5 ANNEXIN 24(CA32)

(Capsicum annuum) 		PF00191
(Annexin) 		5 LEU A 237
VAL A 161
ALA A 118
LEU A 117
LEU A 157
 None
 1.24A 2c12F-1dk5A:
0.0		 2c12F-1dk5A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dq3 ENDONUCLEASE

(Pyrococcus
furiosus) 		PF09061
(Stirrup)
PF09062
(Endonuc_subdom)
PF14528
(LAGLIDADG_3)
PF14890
(Intein_splicing) 		5 LEU A 330
VAL A 391
ALA A 388
SER A 305
LEU A 307
 None
 1.24A 2c12F-1dq3A:
0.0		 2c12F-1dq3A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl9 REVERSE GYRASE

(Archaeoglobus
fulgidus) 		PF00270
(DEAD)
PF01131
(Topoisom_bac)
PF01751
(Toprim) 		5 LEU B 426
VAL B 414
ALA B 461
LEU B 458
SER B 353
 None
 1.19A 2c12F-1gl9B:
1.5		 2c12F-1gl9B:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ixr HOLLIDAY JUNCTION
DNA HELICASE RUVA

(Thermus
thermophilus) 		PF01330
(RuvA_N)
PF14520
(HHH_5) 		5 LEU A  97
VAL A  84
ALA A  87
LEU A  86
LEU A  74
 None
 1.33A 2c12F-1ixrA:
0.0		 2c12F-1ixrA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ixr HOLLIDAY JUNCTION
DNA HELICASE RUVA

(Thermus
thermophilus) 		PF01330
(RuvA_N)
PF14520
(HHH_5) 		5 LEU A 101
VAL A  84
ALA A  87
LEU A  86
LEU A  74
 None
 1.13A 2c12F-1ixrA:
0.0		 2c12F-1ixrA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmu PROTEIN MU-1

(Reovirus sp.) 		PF05993
(Reovirus_M2) 		5 LEU B 326
GLU B 330
LEU B 527
SER B 530
ASP B 534
 None
 1.37A 2c12F-1jmuB:
undetectable		 2c12F-1jmuB:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ktm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF03623
(Focal_AT) 		5 LEU A 998
VAL A 933
ALA A 935
MET A 939
LEU A1028
 None
 1.07A 2c12F-1ktmA:
2.7		 2c12F-1ktmA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m9u EARTHWORM
FIBRINOLYTIC ENZYME

(Eisenia fetida) 		PF00089
(Trypsin) 		5 LEU A 114
VAL A  66
ALA A  83
SER A  51
LEU A  46
 None
 1.32A 2c12F-1m9uA:
undetectable		 2c12F-1m9uA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ntg TYROSYL-TRNA
SYNTHETASE

(Homo sapiens) 		PF01588
(tRNA_bind) 		5 GLN A  50
VAL A  49
LEU A  48
SER A  46
LEU A  29
 None
 0.97A 2c12F-1ntgA:
0.0		 2c12F-1ntgA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oy3 TRANSCRIPTION FACTOR
INHIBITOR
I-KAPPA-B-BETA

(Mus musculus) 		PF12796
(Ank_2)
PF13637
(Ank_4) 		5 LEU D  87
ALA D 101
LEU D 100
LEU D  62
ASP D  59
 None
 1.34A 2c12F-1oy3D:
0.0		 2c12F-1oy3D:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uaa PROTEIN
(ATP-DEPENDENT DNA
HELICASE REP.)

(Escherichia
coli) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		5 LEU A 186
ALA A 103
SER A 106
LEU A 107
ASP A 398
 None
 1.23A 2c12F-1uaaA:
undetectable		 2c12F-1uaaA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1udx THE GTP-BINDING
PROTEIN OBG

(Thermus
thermophilus) 		PF01018
(GTP1_OBG)
PF01926
(MMR_HSR1)
PF09269
(DUF1967) 		5 LEU A 319
ALA A 300
LEU A 299
SER A 272
LEU A 322
 None
 1.09A 2c12F-1udxA:
undetectable		 2c12F-1udxA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ue0 ISOLEUCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1) 		5 LEU A 287
ALA A 250
LEU A 258
SER A 223
LEU A 211
 None
 1.26A 2c12F-1ue0A:
undetectable		 2c12F-1ue0A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v2b 23-KDA POLYPEPTIDE
OF PHOTOSYSTEM II
OXYGEN-EVOLVING
COMPLEX

(Nicotiana
tabacum) 		PF01789
(PsbP) 		5 LEU A  81
GLU A  78
LEU A 114
SER A 130
LEU A 129
 None
 1.17A 2c12F-1v2bA:
undetectable		 2c12F-1v2bA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9s URACIL
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus) 		PF14681
(UPRTase) 		5 MET A 132
VAL A  35
ALA A  32
LEU A  31
LEU A  15
 None
 1.09A 2c12F-1v9sA:
undetectable		 2c12F-1v9sA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrn PHOTOSYNTHETIC
REACTION CENTER
CYTOCHROME C SUBUNIT

(Blastochloris
viridis) 		PF02276
(CytoC_RC) 		5 LEU C 154
VAL C 174
ALA C 177
LEU C 176
LEU C 152
 None
 1.22A 2c12F-1vrnC:
undetectable		 2c12F-1vrnC:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wg8 PREDICTED
S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF01795
(Methyltransf_5) 		5 LEU A 216
VAL A  27
ALA A  29
LEU A  94
LEU A 229
 None
 1.35A 2c12F-1wg8A:
undetectable		 2c12F-1wg8A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wvg CDP-GLUCOSE
4,6-DEHYDRATASE

(Salmonella
enterica) 		PF16363
(GDP_Man_Dehyd) 		5 MET A  89
LEU A  27
ALA A 195
SER A 242
LEU A 241
 APR  A 400 (-4.9A)
None
None
None
None
 1.31A 2c12F-1wvgA:
undetectable		 2c12F-1wvgA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xnf LIPOPROTEIN NLPI

(Escherichia
coli) 		PF07719
(TPR_2)
PF13181
(TPR_8) 		5 LEU A 154
ALA A 182
LEU A 186
SER A 167
LEU A 170
 None
 1.31A 2c12F-1xnfA:
undetectable		 2c12F-1xnfA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y0l CATALYTIC ANTIBODY
FAB 34E4 HEAVY CHAIN

(Homo sapiens;
Mus musculus) 		no annotation 5 LEU H  20
VAL H 111
ALA H  12
SER H  17
LEU H  82
 None
 1.33A 2c12F-1y0lH:
undetectable		 2c12F-1y0lH:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ag1 BENZALDEHYDE LYASE

(Pseudomonas
fluorescens) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 LEU A 224
ALA A 237
LEU A 242
SER A 246
LEU A 248
 None
 1.34A 2c12F-2ag1A:
undetectable		 2c12F-2ag1A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dba SMOOTH MUSCLE CELL
ASSOCIATED
PROTEIN-1, ISOFORM 2

(Homo sapiens) 		PF07719
(TPR_2)
PF13432
(TPR_16) 		5 LEU A 112
GLU A  85
ALA A  88
SER A 106
LEU A 109
 None
 1.31A 2c12F-2dbaA:
undetectable		 2c12F-2dbaA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hhi IMMUNOGENIC PROTEIN
MPT64

(Mycobacterium
tuberculosis) 		PF11738
(DUF3298) 		5 VAL A  90
ALA A 109
SER A  43
LEU A  44
ASP A  40
 None
 1.36A 2c12F-2hhiA:
undetectable		 2c12F-2hhiA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jxm CYTOCHROME F

(Prochlorothrix
hollandica) 		PF01333
(Apocytochr_F_C)
PF16639
(Apocytochr_F_N) 		5 LEU B 152
VAL B 104
ALA B 117
LEU B 116
LEU B  75
 None
 1.16A 2c12F-2jxmB:
undetectable		 2c12F-2jxmB:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ktr SEQUESTOSOME-1

(Rattus
norvegicus) 		PF00564
(PB1) 		5 LEU A  81
GLU A  80
VAL A  73
ALA A  74
LEU A  72
 None
 1.25A 2c12F-2ktrA:
undetectable		 2c12F-2ktrA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ktr SEQUESTOSOME-1

(Rattus
norvegicus) 		PF00564
(PB1) 		5 LEU B 281
GLU B 280
VAL B 273
ALA B 274
LEU B 272
 None
 1.25A 2c12F-2ktrB:
undetectable		 2c12F-2ktrB:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2myi EXODEOXYRIBONUCLEASE
III

(Pseudomonas sp.
Lz4W) 		PF03372
(Exo_endo_phos) 		5 GLN A  34
LEU A  50
ALA A  69
LEU A  70
SER A  72
 None
 1.36A 2c12F-2myiA:
undetectable		 2c12F-2myiA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o42 M11L PROTEIN

(Myxoma virus) 		PF11099
(M11L) 		5 LEU A  68
VAL A  79
ALA A  82
LEU A  81
LEU A  72
 None
 1.24A 2c12F-2o42A:
undetectable		 2c12F-2o42A:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oux MAGNESIUM
TRANSPORTER

(Enterococcus
faecalis) 		PF00571
(CBS)
PF03448
(MgtE_N) 		5 LEU A 119
VAL A 101
ALA A 100
LEU A 103
LEU A 116
 None
 1.34A 2c12F-2ouxA:
undetectable		 2c12F-2ouxA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsq SURFACTIN SYNTHETASE
SUBUNIT 3

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		5 LEU A 692
LEU A 675
SER A 652
LEU A 651
ASP A 664
 None
 1.17A 2c12F-2vsqA:
undetectable		 2c12F-2vsqA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsx BETA-ENOLASE

(Homo sapiens) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 MET A   3
LEU A  77
VAL A  22
ALA A 117
LEU A 116
 None
 0.94A 2c12F-2xsxA:
undetectable		 2c12F-2xsxA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yg6 PUTRESCINE OXIDASE

(Rhodococcus
erythropolis) 		PF01593
(Amino_oxidase) 		5 GLN A 441
LEU A  68
ALA A  19
LEU A  18
SER A 218
 None
 1.36A 2c12F-2yg6A:
undetectable		 2c12F-2yg6A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zvf ALANYL-TRNA
SYNTHETASE

(Archaeoglobus
fulgidus) 		PF02272
(DHHA1) 		5 LEU A 838
GLU A 813
ALA A 802
LEU A 798
ASP A 796
 None
 1.32A 2c12F-2zvfA:
undetectable		 2c12F-2zvfA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a71 EXO-ARABINANASE

(Penicillium
chrysogenum) 		no annotation 5 LEU A 184
ALA A 143
LEU A 123
SER A 110
LEU A 111
 None
 1.02A 2c12F-3a71A:
undetectable		 2c12F-3a71A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aja PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycolicibacterium
smegmatis) 		PF01083
(Cutinase) 		5 LEU A 288
ALA A 241
SER A 142
LEU A 244
ASP A 145
 None
 1.29A 2c12F-3ajaA:
undetectable		 2c12F-3ajaA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cfx UPF0100 PROTEIN
MA_0280

(Methanosarcina
acetivorans) 		PF13531
(SBP_bac_11) 		5 GLN A 172
LEU A 189
VAL A 277
ALA A 204
LEU A 205
 MG  A 703 ( 4.5A)
None
None
None
None
 1.36A 2c12F-3cfxA:
undetectable		 2c12F-3cfxA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3duh INTERLEUKIN-23
SUBUNIT ALPHA

(Homo sapiens) 		PF16649
(IL23) 		5 LEU C  78
ALA C  25
LEU C  24
SER C 108
LEU C 109
 None
 1.17A 2c12F-3duhC:
undetectable		 2c12F-3duhC:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e4f AMINOGLYCOSIDE
N3-ACETYLTRANSFERASE

(Bacillus
anthracis) 		PF02522
(Antibiotic_NAT) 		5 GLU A 155
VAL A 187
LEU A 153
SER A 152
ASP A 214
 None
 1.09A 2c12F-3e4fA:
undetectable		 2c12F-3e4fA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efv PUTATIVE
SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE

(Salmonella
enterica) 		PF00171
(Aldedh) 		5 LEU A 393
VAL A 429
ALA A 430
LEU A 443
SER A 425
 NAD  A 463 ( 4.6A)
None
None
None
None
 1.29A 2c12F-3efvA:
1.7		 2c12F-3efvA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eoq PUTATIVE ZINC
PROTEASE

(Thermus
thermophilus) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 LEU A 314
VAL A 275
ALA A 280
SER A 284
LEU A 270
 None
 1.36A 2c12F-3eoqA:
undetectable		 2c12F-3eoqA:
23.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fcj NITROALKANE OXIDASE

(Fusarium
oxysporum) 		PF00441
(Acyl-CoA_dh_1)
PF02771
(Acyl-CoA_dh_N) 		10 GLN A  61
MET A  70
LEU A  73
GLU A  76
VAL A  95
ALA A  98
LEU A  99
MET A 102
SER A 276
LEU A 279
 None
None
None
None
None
None
NIE  A 600 ( 4.9A)
None
None
None
 0.37A 2c12F-3fcjA:
67.8		 2c12F-3fcjA:
99.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fvr ACETYL XYLAN
ESTERASE

(Bacillus
pumilus) 		PF05448
(AXE1) 		5 LEU A 253
ALA A 157
LEU A 161
SER A 194
LEU A 193
 None
 1.34A 2c12F-3fvrA:
undetectable		 2c12F-3fvrA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gf8 PUTATIVE
POLYSACCHARIDE
BINDING PROTEINS
(DUF1812)

(Bacteroides
thetaiotaomicron) 		PF08842
(Mfa2) 		5 LEU A 186
VAL A 301
ALA A 300
LEU A 299
SER A 297
 None
 1.04A 2c12F-3gf8A:
undetectable		 2c12F-3gf8A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hp4 GDSL-ESTERASE

(Pseudoalteromonas
sp. 643A) 		PF13472
(Lipase_GDSL_2) 		5 GLN A 167
LEU A  12
ALA A 166
MET A 155
ASP A 147
 None
MIR  A  11 ( 4.2A)
None
None
None
 1.28A 2c12F-3hp4A:
undetectable		 2c12F-3hp4A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3il0 XAA-PRO
AMINOPEPTIDASE
AMINOPEPTIDASE P

(Streptococcus
thermophilus) 		PF01321
(Creatinase_N) 		5 LEU A 105
ALA A  19
LEU A  17
SER A 115
LEU A 114
 None
 0.87A 2c12F-3il0A:
undetectable		 2c12F-3il0A:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3io1 AMINOBENZOYL-GLUTAMA
TE UTILIZATION
PROTEIN

(Klebsiella
pneumoniae) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 LEU A 177
VAL A 426
ALA A 427
LEU A 428
LEU A 160
 None
 1.36A 2c12F-3io1A:
undetectable		 2c12F-3io1A:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l84 TRANSKETOLASE

(Campylobacter
jejuni) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 LEU A  61
ALA A  68
SER A  64
LEU A 149
ASP A 154
 None
 1.32A 2c12F-3l84A:
undetectable		 2c12F-3l84A:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxz GLUTATHIONE
S-TRANSFERASE FAMILY
PROTEIN

(Pseudomonas
putida) 		PF13417
(GST_N_3)
PF14497
(GST_C_3) 		5 VAL A  89
ALA A 154
LEU A  93
LEU A  78
ASP A  67
 None
 1.34A 2c12F-3lxzA:
undetectable		 2c12F-3lxzA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m70 TELLURITE RESISTANCE
PROTEIN TEHB HOMOLOG

(Haemophilus
influenzae) 		PF03848
(TehB)
PF09313
(DUF1971) 		5 MET A 276
LEU A 264
VAL A 222
ALA A 223
MET A 195
 None
 1.10A 2c12F-3m70A:
undetectable		 2c12F-3m70A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pb9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE-LIK
E PROTEIN

(Homo sapiens) 		PF04389
(Peptidase_M28) 		5 GLN X  87
LEU X 205
GLU X 204
VAL X  84
LEU X 382
 None
 1.21A 2c12F-3pb9X:
undetectable		 2c12F-3pb9X:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Escherichia
coli) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		5 LEU A 630
VAL A 290
LEU A 292
SER A 276
LEU A 279
 None
 1.16A 2c12F-3ps9A:
undetectable		 2c12F-3ps9A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tpc SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00106
(adh_short) 		5 LEU A  35
VAL A 130
ALA A 127
LEU A 126
MET A 123
 None
 1.18A 2c12F-3tpcA:
undetectable		 2c12F-3tpcA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4o MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1

(Homo sapiens) 		PF00656
(Peptidase_C14) 		5 LEU A 346
VAL A 442
LEU A 446
MET A 449
LEU A 410
 None
 1.31A 2c12F-3v4oA:
undetectable		 2c12F-3v4oA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wq8 BETA-GLUCOSIDASE

(Pyrococcus
furiosus) 		PF00232
(Glyco_hydro_1) 		5 MET A  73
LEU A 412
VAL A 446
LEU A 445
LEU A 428
 None
 1.32A 2c12F-3wq8A:
undetectable		 2c12F-3wq8A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvr PGM1

(Streptomyces
cirratus) 		no annotation 5 LEU A  13
GLU A  12
ALA A 110
LEU A 131
LEU A 137
 None
 1.35A 2c12F-3wvrA:
undetectable		 2c12F-3wvrA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4axv MPAA

(Vibrio
campbellii) 		PF04952
(AstE_AspA) 		5 GLU A  36
VAL A  35
ALA A  33
SER A  39
ASP A 233
 None
 1.36A 2c12F-4axvA:
undetectable		 2c12F-4axvA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4az7 BETA-N-ACETYLHEXOSAM
INIDASE

(Streptococcus
pneumoniae) 		PF00728
(Glyco_hydro_20) 		5 MET A 274
LEU A 288
ALA A 194
SER A 191
LEU A 219
 None
 1.16A 2c12F-4az7A:
3.6		 2c12F-4az7A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d6v G PROTEIN BETA
SUBUNIT GIB2

(Cryptococcus
neoformans) 		PF00400
(WD40) 		5 VAL A 200
ALA A 207
LEU A 206
SER A 205
ASP A 203
 None
 0.94A 2c12F-4d6vA:
undetectable		 2c12F-4d6vA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dhx 80 KDA
MCM3-ASSOCIATED
PROTEIN
ENHANCER OF YELLOW 2
TRANSCRIPTION FACTOR
HOMOLOG

(Homo sapiens) 		PF10163
(EnY2)
PF16766
(CID_GANP) 		5 LEU B  20
VAL A1173
LEU B  88
SER A1168
LEU A1171
 None
 1.23A 2c12F-4dhxB:
undetectable		 2c12F-4dhxB:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gkh AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB

(Acinetobacter
baumannii) 		PF01636
(APH) 		5 LEU A 236
ALA A 106
SER A 200
LEU A 232
ASP A 198
 None
None
KAN  A 301 ( 4.8A)
None
KAN  A 301 (-3.0A)
 1.35A 2c12F-4gkhA:
undetectable		 2c12F-4gkhA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htf S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE

(Escherichia
coli) 		PF13847
(Methyltransf_31) 		5 LEU B 132
ALA B  51
LEU B 117
SER B 146
LEU B 145
 None
 1.33A 2c12F-4htfB:
undetectable		 2c12F-4htfB:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1p MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1

(Homo sapiens) 		PF00656
(Peptidase_C14) 		5 LEU A 346
VAL A 442
LEU A 446
MET A 449
LEU A 410
 None
 1.29A 2c12F-4i1pA:
undetectable		 2c12F-4i1pA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l4x AMPHI

(Streptomyces
nodosus) 		PF08659
(KR) 		5 GLN A 166
VAL A 162
ALA A 163
LEU A 160
LEU A 379
 None
 1.34A 2c12F-4l4xA:
undetectable		 2c12F-4l4xA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lih GAMMA-GLUTAMYL-GAMMA
-AMINOBUTYRALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		5 LEU A  16
GLU A 100
LEU A  98
SER A 102
LEU A 104
 None
 1.34A 2c12F-4lihA:
1.4		 2c12F-4lihA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mx8 PERIPLASMIC BINDING
PROTEIN

(Xylanimonas
cellulosilytica) 		PF01497
(Peripla_BP_2) 		5 LEU A  81
LEU A  91
MET A  52
SER A  72
LEU A  70
 None
 1.25A 2c12F-4mx8A:
undetectable		 2c12F-4mx8A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6m AF2299, A
CDP-ALCOHOL
PHOSPHOTRANSFERASE

(Archaeoglobus
fulgidus) 		PF01066
(CDP-OH_P_transf) 		5 LEU A 223
ALA A 126
LEU A 129
SER A 132
LEU A 131
 None
 1.35A 2c12F-4o6mA:
1.5		 2c12F-4o6mA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0c ABGT PUTATIVE
TRANSPORTER FAMILY

(Alcanivorax
borkumensis) 		PF03806
(ABG_transport) 		5 GLU A 189
VAL A 348
ALA A 345
MET A 341
SER A 401
 None
 1.32A 2c12F-4r0cA:
1.9		 2c12F-4r0cA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uf9 SEQUESTOSOME-1

(Homo sapiens) 		PF00564
(PB1) 		5 LEU A  83
GLU A  82
VAL A  75
ALA A  76
LEU A  74
 None
 1.24A 2c12F-4uf9A:
undetectable		 2c12F-4uf9A:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uqg DNA POLYMERASE

(Geobacillus
stearothermophilus) 		PF00476
(DNA_pol_A) 		5 LEU A 485
ALA A 609
LEU A 610
SER A 617
LEU A 616
 None
SUC  A 877 ( 4.0A)
None
None
None
 1.24A 2c12F-4uqgA:
3.5		 2c12F-4uqgA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wyk NTF2-RELATED EXPORT
PROTEIN 1
NUCLEAR RNA EXPORT
FACTOR 1

(Homo sapiens) 		PF02136
(NTF2) 		5 LEU A 469
LEU A 455
SER A 417
LEU A 418
ASP B  76
 None
 1.28A 2c12F-4wykA:
undetectable		 2c12F-4wykA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymk ACYL-COA DESATURASE
1

(Mus musculus) 		PF00487
(FA_desaturase) 		5 LEU A 109
ALA A 329
LEU A 328
MET A 323
LEU A 134
 None
 1.21A 2c12F-4ymkA:
undetectable		 2c12F-4ymkA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE

(Neurospora
crassa) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		5 LEU A 187
VAL A 221
ALA A 224
SER A 165
LEU A 167
 None
 1.20A 2c12F-4ztxA:
undetectable		 2c12F-4ztxA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyo ACYL-COA DESATURASE

(Homo sapiens) 		no annotation 5 LEU A 113
ALA A 333
LEU A 332
MET A 327
LEU A 138
 None
 1.20A 2c12F-4zyoA:
undetectable		 2c12F-4zyoA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c8c VP0
VP1

(Enterovirus A) 		PF00073
(Rhv)
PF02226
(Pico_P1A) 		5 LEU B 244
ALA B 237
LEU B 201
LEU B 196
ASP A 206
 None
 1.30A 2c12F-5c8cB:
undetectable		 2c12F-5c8cB:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgq PUTATIVE
ENDOGLUCANASE-RELATE
D PROTEIN

(Photobacterium
profundum) 		PF00759
(Glyco_hydro_9) 		5 GLN A 346
LEU A 342
ALA A 402
LEU A 403
LEU A 379
 None
 1.15A 2c12F-5dgqA:
undetectable		 2c12F-5dgqA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6s INTEGRIN ALPHA-L

(Homo sapiens) 		PF00092
(VWA)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		5 LEU A 111
ALA A  75
LEU A 333
SER A  82
ASP A  80
 None
 1.02A 2c12F-5e6sA:
undetectable		 2c12F-5e6sA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ere EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Desulfohalobium
retbaense) 		PF13458
(Peripla_BP_6) 		5 LEU A 293
GLU A 289
LEU A 128
LEU A 139
ASP A 334
 None
 1.16A 2c12F-5ereA:
undetectable		 2c12F-5ereA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fku DNA POLYMERASE III
SUBUNIT TAU

(Escherichia
coli) 		PF12170
(DNA_pol3_tau_5) 		5 LEU E 576
VAL E 539
ALA E 543
LEU E 541
LEU E 572
 None
 1.32A 2c12F-5fkuE:
undetectable		 2c12F-5fkuE:
15.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fw4 DYE-DECOLORIZING
PEROXIDASE TFU_3078

(Thermobifida
fusca) 		PF04261
(Dyp_perox) 		5 LEU A  75
VAL A 156
ALA A 159
LEU A 157
LEU A  79
 None
 1.33A 2c12F-5fw4A:
undetectable		 2c12F-5fw4A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy4 RING-OPENING
AMIDOHYDROLASE

(Frankia sp.
Eul1b) 		PF09663
(Amido_AtzD_TrzD) 		5 GLN A 113
LEU A 262
ALA A  18
LEU A 274
LEU A 264
 None
 1.05A 2c12F-5hy4A:
undetectable		 2c12F-5hy4A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy4 RING-OPENING
AMIDOHYDROLASE

(Frankia sp.
Eul1b) 		PF09663
(Amido_AtzD_TrzD) 		5 LEU A 262
ALA A  18
LEU A 274
MET A  20
LEU A 264
 None
 1.30A 2c12F-5hy4A:
undetectable		 2c12F-5hy4A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5icv N-ALPHA-ACETYLTRANSF
ERASE 60

(Homo sapiens) 		PF00583
(Acetyltransf_1) 		5 LEU A 116
ALA A  69
LEU A  99
SER A 100
LEU A 101
 None
 1.19A 2c12F-5icvA:
undetectable		 2c12F-5icvA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ko3 ORF1A

(Middle East
respiratory
syndrome-related
coronavirus) 		PF08715
(Viral_protease) 		5 MET A 185
LEU A 218
SER A 247
LEU A 246
ASP A 309
 None
 1.25A 2c12F-5ko3A:
undetectable		 2c12F-5ko3A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01266
(DAO)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF16350
(FAO_M) 		5 LEU A 847
GLU A 721
SER A 812
LEU A 813
ASP A 783
 None
 1.26A 2c12F-5l46A:
undetectable		 2c12F-5l46A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swv PENTAFUNCTIONAL AROM
POLYPEPTIDE

(Schizosaccharomyces
pombe) 		PF01487
(DHquinase_I)
PF08501
(Shikimate_dh_N) 		5 MET C1236
LEU C1240
ALA C1203
SER C1180
ASP C1155
 None
 1.24A 2c12F-5swvC:
undetectable		 2c12F-5swvC:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swv PENTAFUNCTIONAL AROM
POLYPEPTIDE

(Schizosaccharomyces
pombe) 		PF01487
(DHquinase_I)
PF08501
(Shikimate_dh_N) 		5 MET C1236
LEU C1240
ALA C1207
SER C1180
ASP C1155
 None
 1.24A 2c12F-5swvC:
undetectable		 2c12F-5swvC:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8s DNA REPLICATION
LICENSING FACTOR
MCM4

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		5 GLN 4 876
LEU 4 919
VAL 4 872
LEU 4 873
SER 4 926
 None
 1.20A 2c12F-5u8s4:
undetectable		 2c12F-5u8s4:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uc7 ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(environmental
samples) 		PF00202
(Aminotran_3) 		5 LEU A 108
VAL A 319
ALA A 318
LEU A 315
LEU A 283
 None
 1.31A 2c12F-5uc7A:
undetectable		 2c12F-5uc7A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyw PYRUVATE CARBOXYLASE

(Lactococcus
lactis) 		PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 LEU A 539
VAL A 802
SER A 761
LEU A 762
ASP A 796
 None
 1.22A 2c12F-5vywA:
undetectable		 2c12F-5vywA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w8u ORF1AB PROTEIN

(Middle East
respiratory
syndrome-related
coronavirus) 		PF08715
(Viral_protease) 		5 MET A 185
LEU A 218
SER A 247
LEU A 246
ASP A 309
 None
 1.29A 2c12F-5w8uA:
undetectable		 2c12F-5w8uA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6o SERINE/THREONINE-PRO
TEIN KINASE MEC1

(Saccharomyces
cerevisiae) 		no annotation 5 GLN C1695
GLU C1724
LEU C1693
SER C1709
LEU C1710
 None
 0.88A 2c12F-5x6oC:
undetectable		 2c12F-5x6oC:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xd6 PROTEIN KINASE
SUPERFAMILY PROTEIN

(Arabidopsis
thaliana) 		no annotation 5 LEU A 168
ALA A 213
LEU A 206
SER A 148
LEU A 149
 None
None
ANP  A1000 (-4.5A)
ANP  A1000 ( 4.4A)
None
 1.29A 2c12F-5xd6A:
undetectable		 2c12F-5xd6A:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xe7 ECF RNA POLYMERASE
SIGMA FACTOR SIGJ

(Mycobacterium
tuberculosis) 		PF04542
(Sigma70_r2)
PF08281
(Sigma70_r4_2)
PF12680
(SnoaL_2) 		5 LEU A  64
ALA A 120
LEU A 123
SER A  57
LEU A  61
 None
 1.12A 2c12F-5xe7A:
undetectable		 2c12F-5xe7A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aun PLA2G6, IPLA2BETA

(Cricetulus
griseus) 		no annotation 5 LEU A 506
VAL A 576
ALA A 579
LEU A 575
LEU A 510
 None
 1.29A 2c12F-6aunA:
undetectable		 2c12F-6aunA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
BETA

(Pyrococcus
furiosus) 		no annotation 5 GLN L  49
MET K 120
LEU K 136
VAL L  48
LEU L  45
 None
 1.28A 2c12F-6cfwL:
1.4		 2c12F-6cfwL:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dku VP35

(Myotis
lucifugus) 		no annotation 5 LEU A 262
VAL A 199
ALA A 200
LEU A 197
SER A 191
 None
 1.16A 2c12F-6dkuA:
undetectable		 2c12F-6dkuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eq8 PERIPLASMIC
ALPHA-GALACTOSIDE-BI
NDING PROTEIN

(Agrobacterium
tumefaciens) 		no annotation 5 LEU D 548
GLU D 537
LEU D 362
SER D 426
LEU D 538
 None
 1.31A 2c12F-6eq8D:
undetectable		 2c12F-6eq8D:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fkh ATP SYNTHASE GAMMA
CHAIN, CHLOROPLASTIC
ATP SYNTHASE SUBUNIT
ALPHA, CHLOROPLASTIC

(Spinacia
oleracea) 		no annotation 5 LEU C 411
VAL g  67
ALA g  63
LEU g  66
LEU C 403
 None
 1.32A 2c12F-6fkhC:
undetectable		 2c12F-6fkhC:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4

(Mus musculus) 		no annotation 5 GLN M 103
LEU M  77
LEU M  12
SER M  97
LEU M  99
 None
None
3PE  M 505 ( 4.9A)
3PE  M 505 (-3.4A)
None
 1.29A 2c12F-6g2jM:
undetectable		 2c12F-6g2jM:
12.30