SIMILAR PATTERNS OF AMINO ACIDS FOR 2C12_C_SPMC1434_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dk5 ANNEXIN 24(CA32)

(Capsicum annuum) 		PF00191
(Annexin) 		5 LEU A 237
VAL A 161
ALA A 118
LEU A 117
LEU A 157
 None
 1.25A 2c12C-1dk5A:
0.0		 2c12C-1dk5A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl9 REVERSE GYRASE

(Archaeoglobus
fulgidus) 		PF00270
(DEAD)
PF01131
(Topoisom_bac)
PF01751
(Toprim) 		5 LEU B 426
VAL B 414
ALA B 461
LEU B 458
SER B 353
 None
 1.15A 2c12C-1gl9B:
0.0		 2c12C-1gl9B:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcz BETA-METHYLASPARTASE

(Clostridium
tetanomorphum) 		PF05034
(MAAL_N)
PF07476
(MAAL_C) 		5 LEU A 291
ALA A 302
LEU A 270
LEU A 304
VAL A 305
 None
 1.00A 2c12C-1kczA:
0.0		 2c12C-1kczA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ntg TYROSYL-TRNA
SYNTHETASE

(Homo sapiens) 		PF01588
(tRNA_bind) 		5 GLN A  50
VAL A  49
LEU A  48
SER A  46
LEU A  29
 None
 0.97A 2c12C-1ntgA:
undetectable		 2c12C-1ntgA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u3i GLUTATHIONE
S-TRANSFERASE 28 KDA

(Schistosoma
mansoni) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 LEU A 143
VAL A 162
LEU A 161
LEU A  98
VAL A  95
 None
 1.22A 2c12C-1u3iA:
2.9		 2c12C-1u3iA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uou THYMIDINE
PHOSPHORYLASE

(Homo sapiens) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		5 LEU A 262
ALA A  94
LEU A  95
SER A 220
VAL A 224
 None
 1.24A 2c12C-1uouA:
0.0		 2c12C-1uouA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v2b 23-KDA POLYPEPTIDE
OF PHOTOSYSTEM II
OXYGEN-EVOLVING
COMPLEX

(Nicotiana
tabacum) 		PF01789
(PsbP) 		5 LEU A  81
GLU A  78
LEU A 114
SER A 130
LEU A 129
 None
 1.19A 2c12C-1v2bA:
undetectable		 2c12C-1v2bA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrn PHOTOSYNTHETIC
REACTION CENTER
CYTOCHROME C SUBUNIT

(Blastochloris
viridis) 		PF02276
(CytoC_RC) 		5 LEU C 154
VAL C 174
ALA C 177
LEU C 176
LEU C 152
 None
 1.15A 2c12C-1vrnC:
undetectable		 2c12C-1vrnC:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wky ENDO-BETA-1,4-MANNAN
ASE

(Bacillus sp.
JAMB-602) 		PF00150
(Cellulase) 		5 LEU A 103
SER A  87
LEU A  86
VAL A 118
ASP A 120
 None
 1.07A 2c12C-1wkyA:
0.0		 2c12C-1wkyA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xg0 B-PHYCOERYTHRIN BETA
CHAIN

(Rhodomonas sp.
CS24) 		PF00502
(Phycobilisome) 		5 VAL C 165
ALA C 162
LEU C 161
SER C  40
VAL C  41
 None
None
None
PEB  C 258 (-3.1A)
None
 1.23A 2c12C-1xg0C:
undetectable		 2c12C-1xg0C:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xhk PUTATIVE PROTEASE LA
HOMOLOG

(Methanocaldococcus
jannaschii) 		PF05362
(Lon_C) 		5 LEU A 629
LEU A 563
SER A 512
LEU A 515
VAL A 516
 None
 0.91A 2c12C-1xhkA:
0.0		 2c12C-1xhkA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aug GROWTH FACTOR
RECEPTOR-BOUND
PROTEIN 14

(Homo sapiens) 		PF00017
(SH2) 		5 LEU A 527
LEU A 464
SER A 478
LEU A 477
VAL A 476
 None
 1.24A 2c12C-2augA:
undetectable		 2c12C-2augA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE

(Thermus
thermophilus) 		PF01053
(Cys_Met_Meta_PP) 		5 LEU A  88
VAL A 171
ALA A 172
LEU A 173
VAL A  99
 None
 1.06A 2c12C-2cb1A:
undetectable		 2c12C-2cb1A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ctz O-ACETYL-L-HOMOSERIN
E SULFHYDRYLASE

(Thermus
thermophilus) 		PF01053
(Cys_Met_Meta_PP) 		5 LEU A  90
VAL A 175
ALA A 176
LEU A 177
VAL A 101
 None
 1.04A 2c12C-2ctzA:
undetectable		 2c12C-2ctzA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dcr PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FES/FPS

(Homo sapiens) 		PF00017
(SH2) 		5 LEU A  95
LEU A  39
SER A  52
LEU A  51
VAL A  50
 None
 1.22A 2c12C-2dcrA:
undetectable		 2c12C-2dcrA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eyv V-CRK SARCOMA VIRUS
CT10 ONCOGENE
HOMOLOG ISOFORM A

(Homo sapiens) 		PF00017
(SH2) 		5 LEU A 109
LEU A  36
SER A  50
LEU A  49
VAL A  48
 None
 1.15A 2c12C-2eyvA:
undetectable		 2c12C-2eyvA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g02 NISIN BIOSYNTHESIS
PROTEIN NISC

(Lactococcus
lactis) 		PF05147
(LANC_like) 		5 LEU A  48
GLU A  52
LEU A 407
LEU A 387
VAL A 388
 None
 1.07A 2c12C-2g02A:
undetectable		 2c12C-2g02A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h1y MALONYL COENZYME
A-ACYL CARRIER
PROTEIN TRANSACYLASE

(Helicobacter
pylori) 		PF00698
(Acyl_transf_1) 		5 GLU A  95
ALA A 229
SER A 245
LEU A 244
VAL A 241
 None
 1.19A 2c12C-2h1yA:
2.1		 2c12C-2h1yA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnk SAM-DEPENDENT
O-METHYLTRANSFERASE

(Leptospira
interrogans) 		PF01596
(Methyltransf_3) 		5 LEU A  55
LEU A 218
SER A 226
LEU A 227
VAL A 228
 None
 1.14A 2c12C-2hnkA:
undetectable		 2c12C-2hnkA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iop CHAPERONE PROTEIN
HTPG

(Escherichia
coli) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		5 LEU A 330
ALA A 310
MET A 307
SER A 335
LEU A 339
 None
 1.19A 2c12C-2iopA:
undetectable		 2c12C-2iopA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3t TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT 4

(Homo sapiens) 		PF04099
(Sybindin) 		5 GLN D 163
LEU D 206
ALA D 159
LEU D 158
SER D   5
 None
 1.25A 2c12C-2j3tD:
undetectable		 2c12C-2j3tD:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j67 TOLL LIKE RECEPTOR
10

(Homo sapiens) 		PF01582
(TIR) 		5 LEU A 749
SER A 697
LEU A 696
VAL A 695
ASP A 644
 None
 0.99A 2c12C-2j67A:
undetectable		 2c12C-2j67A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jxm CYTOCHROME F

(Prochlorothrix
hollandica) 		PF01333
(Apocytochr_F_C)
PF16639
(Apocytochr_F_N) 		5 LEU B 152
VAL B 104
ALA B 117
LEU B 116
LEU B  75
 None
 1.19A 2c12C-2jxmB:
undetectable		 2c12C-2jxmB:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kbf ATP-DEPENDENT RNA
HELICASE DBP5

(Saccharomyces
cerevisiae) 		PF00271
(Helicase_C) 		5 LEU A 390
ALA A 343
LEU A 346
LEU A 384
VAL A 383
 None
 1.16A 2c12C-2kbfA:
undetectable		 2c12C-2kbfA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oi2 MEVALONATE KINASE

(Streptococcus
pneumoniae) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 MET A 158
LEU A  16
ALA A 162
LEU A 164
VAL A 165
 None
 1.10A 2c12C-2oi2A:
undetectable		 2c12C-2oi2A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qrd SPCC1919.03C PROTEIN

(Schizosaccharomyces
pombe) 		PF04739
(AMPKBI) 		5 LEU B 241
SER B 252
LEU B 254
VAL B 253
ASP B 250
 None
 1.13A 2c12C-2qrdB:
undetectable		 2c12C-2qrdB:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfq 3-HSA HYDROXYLASE,
OXYGENASE

(Rhodococcus
jostii) 		PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		5 LEU A  95
SER A 206
LEU A 205
VAL A 164
ASP A 162
 None
 1.16A 2c12C-2rfqA:
31.1		 2c12C-2rfqA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uw2 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE M2
SUBUNIT

(Homo sapiens) 		PF00268
(Ribonuc_red_sm) 		5 LEU A 335
VAL A 297
ALA A 296
LEU A 331
VAL A 327
 None
 1.20A 2c12C-2uw2A:
3.3		 2c12C-2uw2A:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsq SURFACTIN SYNTHETASE
SUBUNIT 3

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		5 LEU A 692
LEU A 675
SER A 652
LEU A 651
ASP A 664
 None
 1.12A 2c12C-2vsqA:
undetectable		 2c12C-2vsqA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5c PROTEIN YPL144W

(Saccharomyces
cerevisiae) 		PF10448
(POC3_POC4) 		5 LEU A 142
ALA A 101
SER A  39
LEU A  40
VAL A  41
 None
 1.20A 2c12C-2z5cA:
undetectable		 2c12C-2z5cA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a71 EXO-ARABINANASE

(Penicillium
chrysogenum) 		no annotation 5 LEU A 184
ALA A 143
LEU A 123
SER A 110
LEU A 111
 None
 1.02A 2c12C-3a71A:
undetectable		 2c12C-3a71A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aj2 CELLULOSE SYNTHASE
OPERON PROTEIN D

(Komagataeibacter
xylinus) 		PF03500
(Cellsynth_D) 		5 MET A 147
GLU A 109
ALA A 105
LEU A 104
VAL A  37
 None
 1.15A 2c12C-3aj2A:
undetectable		 2c12C-3aj2A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aq0 GERANYL DIPHOSPHATE
SYNTHASE

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		5 LEU A 197
ALA A 102
LEU A 139
LEU A 165
VAL A 166
 None
FPP  A1002 (-4.1A)
None
FPP  A1002 ( 4.6A)
FPP  A1002 ( 4.1A)
 1.02A 2c12C-3aq0A:
undetectable		 2c12C-3aq0A:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3awk CHALCONE
SYNTHASE-LIKE
POLYKETIDE SYNTHASE

(Huperzia
serrata) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 LEU A 154
ALA A 123
LEU A 232
LEU A 197
VAL A 196
 None
 1.15A 2c12C-3awkA:
undetectable		 2c12C-3awkA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dr5 PUTATIVE
O-METHYLTRANSFERASE

(Corynebacterium
glutamicum) 		PF13578
(Methyltransf_24) 		5 MET A 122
LEU A 145
LEU A 132
LEU A 159
VAL A 209
 None
 1.21A 2c12C-3dr5A:
undetectable		 2c12C-3dr5A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3duh INTERLEUKIN-23
SUBUNIT ALPHA

(Homo sapiens) 		PF16649
(IL23) 		5 LEU C  78
ALA C  25
LEU C  24
SER C 108
LEU C 109
 None
 1.16A 2c12C-3duhC:
undetectable		 2c12C-3duhC:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e4f AMINOGLYCOSIDE
N3-ACETYLTRANSFERASE

(Bacillus
anthracis) 		PF02522
(Antibiotic_NAT) 		5 GLU A 155
VAL A 187
LEU A 153
SER A 152
ASP A 214
 None
 1.17A 2c12C-3e4fA:
undetectable		 2c12C-3e4fA:
21.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fcj NITROALKANE OXIDASE

(Fusarium
oxysporum) 		PF00441
(Acyl-CoA_dh_1)
PF02771
(Acyl-CoA_dh_N) 		11 GLN A  61
MET A  70
LEU A  73
GLU A  76
VAL A  95
ALA A  98
LEU A  99
MET A 102
SER A 276
LEU A 279
VAL A 280
 None
None
None
None
None
None
NIE  A 600 ( 4.9A)
None
None
None
None
 0.43A 2c12C-3fcjA:
68.3		 2c12C-3fcjA:
99.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gf8 PUTATIVE
POLYSACCHARIDE
BINDING PROTEINS
(DUF1812)

(Bacteroides
thetaiotaomicron) 		PF08842
(Mfa2) 		5 LEU A 186
VAL A 301
ALA A 300
LEU A 299
SER A 297
 None
 1.09A 2c12C-3gf8A:
undetectable		 2c12C-3gf8A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hh1 TETRAPYRROLE
METHYLASE FAMILY
PROTEIN

(Chlorobaculum
tepidum) 		PF00590
(TP_methylase) 		5 LEU A  50
VAL A  85
ALA A  86
LEU A  87
VAL A  61
 None
 1.11A 2c12C-3hh1A:
undetectable		 2c12C-3hh1A:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hs8 ADAPTOR PROTEIN
COMPLEX AP-2, ALPHA
2 SUBUNIT

(Mus musculus) 		PF02296
(Alpha_adaptin_C)
PF02883
(Alpha_adaptinC2) 		5 LEU A 756
LEU A 726
MET A 737
LEU A 801
VAL A 816
 None
 1.20A 2c12C-3hs8A:
undetectable		 2c12C-3hs8A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6x RRNA METHYLASE

(Thermus
thermophilus) 		PF01189
(Methyltr_RsmB-F)
PF17125
(Methyltr_RsmF_N)
PF17126
(RsmF_methylt_CI) 		5 LEU A 163
ALA A 154
LEU A 153
LEU A 106
VAL A 105
 None
 1.17A 2c12C-3m6xA:
undetectable		 2c12C-3m6xA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m70 TELLURITE RESISTANCE
PROTEIN TEHB HOMOLOG

(Haemophilus
influenzae) 		PF03848
(TehB)
PF09313
(DUF1971) 		5 MET A 276
LEU A 264
VAL A 222
ALA A 223
MET A 195
 None
 1.19A 2c12C-3m70A:
undetectable		 2c12C-3m70A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mem PUTATIVE SIGNAL
TRANSDUCTION PROTEIN

(Marinobacter
hydrocarbonoclasticus) 		PF04073
(tRNA_edit)
PF08668
(HDOD) 		5 MET A 369
LEU A 309
ALA A 260
LEU A 259
VAL A 252
 None
 1.20A 2c12C-3memA:
undetectable		 2c12C-3memA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mfd D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACB

(Bacillus
subtilis) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		5 LEU A 208
VAL A 245
ALA A 244
MET A 259
LEU A 231
 None
 1.25A 2c12C-3mfdA:
undetectable		 2c12C-3mfdA:
20.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mkh NITROALKANE OXIDASE

(Podospora
anserina) 		PF00441
(Acyl-CoA_dh_1)
PF02771
(Acyl-CoA_dh_N) 		6 LEU A  75
LEU A 101
SER A 273
LEU A 276
VAL A 277
ASP A 399
 None
 0.85A 2c12C-3mkhA:
56.8		 2c12C-3mkhA:
44.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pb9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE-LIK
E PROTEIN

(Homo sapiens) 		PF04389
(Peptidase_M28) 		5 GLN X  87
LEU X 205
GLU X 204
VAL X  84
LEU X 382
 None
 1.25A 2c12C-3pb9X:
undetectable		 2c12C-3pb9X:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Escherichia
coli) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		5 LEU A 630
VAL A 290
LEU A 292
SER A 276
LEU A 279
 None
 1.20A 2c12C-3ps9A:
undetectable		 2c12C-3ps9A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qvm OLEI00960

(Oleispira
antarctica) 		PF00561
(Abhydrolase_1) 		5 LEU A  31
VAL A 118
ALA A 114
LEU A  91
VAL A  92
 None
 1.13A 2c12C-3qvmA:
undetectable		 2c12C-3qvmA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r8c CYTIDYLATE KINASE

(Mycobacteroides
abscessus) 		PF02224
(Cytidylate_kin) 		5 MET A   0
LEU A  23
VAL A   4
LEU A  19
VAL A  15
 None
 0.97A 2c12C-3r8cA:
undetectable		 2c12C-3r8cA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rcm TATD FAMILY
HYDROLASE

(Pseudomonas
putida) 		PF01026
(TatD_DNase) 		5 LEU A 116
GLU A 113
ALA A 143
LEU A 142
LEU A 100
 None
 1.10A 2c12C-3rcmA:
undetectable		 2c12C-3rcmA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqn CONSERVED DOMAIN
PROTEIN

(Enterococcus
faecalis) 		PF05043
(Mga) 		5 LEU A 100
GLU A  99
LEU A 112
LEU A 106
VAL A 107
 None
 1.01A 2c12C-3sqnA:
undetectable		 2c12C-3sqnA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5q NUCLEOPROTEIN

(Mopeia Lassa
virus
reassortant 29) 		PF00843
(Arena_nucleocap) 		5 LEU A  39
VAL A 199
ALA A 198
LEU A 202
VAL A  31
 None
 1.13A 2c12C-3t5qA:
undetectable		 2c12C-3t5qA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uv1 DER F 7 ALLERGEN

(Dermatophagoides
farinae) 		PF16984
(Grp7_allergen) 		5 LEU A 193
VAL A  75
ALA A  73
SER A 126
LEU A 127
 None
 1.06A 2c12C-3uv1A:
undetectable		 2c12C-3uv1A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4o MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1

(Homo sapiens) 		PF00656
(Peptidase_C14) 		5 LEU A 519
VAL A 380
ALA A 345
LEU A 369
VAL A 366
 None
 1.15A 2c12C-3v4oA:
undetectable		 2c12C-3v4oA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4o MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1

(Homo sapiens) 		PF00656
(Peptidase_C14) 		5 VAL A 380
ALA A 345
LEU A 346
LEU A 369
VAL A 366
 None
 1.05A 2c12C-3v4oA:
undetectable		 2c12C-3v4oA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vps NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E

(Streptomyces
chartreusis) 		PF01370
(Epimerase) 		5 LEU A  62
ALA A  77
LEU A  76
LEU A  37
VAL A  36
 None
NAD  A 401 (-3.6A)
NAD  A 401 (-4.2A)
None
None
 1.11A 2c12C-3vpsA:
undetectable		 2c12C-3vpsA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zpl PUTATIVE MARR-FAMILY
TRANSCRIPTIONAL
REPRESSOR

(Streptomyces
coelicolor) 		PF12802
(MarR_2) 		5 LEU A  82
ALA A  38
LEU A  34
LEU A  48
VAL A  49
 None
 1.10A 2c12C-3zplA:
undetectable		 2c12C-3zplA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aie GLUCAN
1,6-ALPHA-GLUCOSIDAS
E

(Lactobacillus
acidophilus) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		5 MET A 345
LEU A 294
VAL A 493
LEU A 479
VAL A 478
 None
 1.21A 2c12C-4aieA:
undetectable		 2c12C-4aieA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aie GLUCAN
1,6-ALPHA-GLUCOSIDAS
E

(Lactobacillus
acidophilus) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		5 MET A 345
LEU A 294
VAL A 493
MET A 337
LEU A 479
 None
 1.17A 2c12C-4aieA:
undetectable		 2c12C-4aieA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4am3 POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Caulobacter
vibrioides) 		PF00013
(KH_1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		5 LEU A 413
ALA A 343
SER A 431
LEU A 429
VAL A 430
 None
 1.22A 2c12C-4am3A:
undetectable		 2c12C-4am3A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b0n POLYKETIDE SYNTHASE
III

(Ectocarpus
siliculosus) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 LEU A 125
VAL A 133
ALA A 132
LEU A 166
ASP A 171
 None
None
None
MLA  A1415 (-4.1A)
None
 1.15A 2c12C-4b0nA:
undetectable		 2c12C-4b0nA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d6v G PROTEIN BETA
SUBUNIT GIB2

(Cryptococcus
neoformans) 		PF00400
(WD40) 		5 VAL A 200
ALA A 207
LEU A 206
SER A 205
ASP A 203
 None
 0.95A 2c12C-4d6vA:
undetectable		 2c12C-4d6vA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dhx 80 KDA
MCM3-ASSOCIATED
PROTEIN
ENHANCER OF YELLOW 2
TRANSCRIPTION FACTOR
HOMOLOG

(Homo sapiens) 		PF10163
(EnY2)
PF16766
(CID_GANP) 		5 LEU B  20
VAL A1173
LEU B  88
SER A1168
LEU A1171
 None
 1.18A 2c12C-4dhxB:
undetectable		 2c12C-4dhxB:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4drt DE NOVO DESIGNED
SERINE HYDROLASE,
OR89

(synthetic
construct) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		5 LEU A 320
GLU A 279
ALA A 277
LEU A 315
VAL A 314
 None
 1.18A 2c12C-4drtA:
undetectable		 2c12C-4drtA:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		5 LEU A 537
LEU A 481
SER A 494
LEU A 493
VAL A 492
 None
 1.22A 2c12C-4e93A:
undetectable		 2c12C-4e93A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e9l ATTACHING AND
EFFACING PROTEIN,
PATHOGENESIS FACTOR

(Escherichia
coli) 		PF09134
(Invasin_D3) 		5 LEU A 960
ALA A 936
SER A 970
LEU A 987
VAL A 986
 None
 1.22A 2c12C-4e9lA:
undetectable		 2c12C-4e9lA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f5x RNA-DIRECTED RNA
POLYMERASE

(Rotavirus A) 		PF02123
(RdRP_4)
PF12289
(Rotavirus_VP1) 		5 LEU W 288
MET W 322
LEU W 311
VAL W 312
ASP W 313
 None
 1.20A 2c12C-4f5xW:
undetectable		 2c12C-4f5xW:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htf S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE

(Escherichia
coli) 		PF13847
(Methyltransf_31) 		5 LEU B 132
LEU B 117
SER B 146
LEU B 145
VAL B 144
 None
 1.10A 2c12C-4htfB:
undetectable		 2c12C-4htfB:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1p MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1

(Homo sapiens) 		PF00656
(Peptidase_C14) 		5 VAL A 380
ALA A 345
LEU A 346
LEU A 369
VAL A 366
 None
 1.19A 2c12C-4i1pA:
undetectable		 2c12C-4i1pA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlv C-TERMINAL FRAGMENT
OF MEMBRANE PROTEIN
CAPA1, PUTATIVE
UNCHARACTERIZED
PROTEIN CAPB1

(Staphylococcus
aureus) 		PF13614
(AAA_31) 		5 VAL A1180
ALA A1053
SER A1056
VAL A1059
ASP A1157
 None
ADP  A1301 (-3.9A)
MG  A1302 ( 2.6A)
None
MG  A1302 ( 4.7A)
 1.02A 2c12C-4jlvA:
undetectable		 2c12C-4jlvA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4krc PHO85 CYCLIN-10

(Saccharomyces
cerevisiae) 		PF08613
(Cyclin) 		5 LEU B 403
GLU B 399
SER B 370
LEU B 369
VAL B 367
 None
 1.25A 2c12C-4krcB:
undetectable		 2c12C-4krcB:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4krc PHO85 CYCLIN-10

(Saccharomyces
cerevisiae) 		PF08613
(Cyclin) 		5 LEU B 403
LEU B 374
SER B 370
LEU B 369
VAL B 367
 None
 1.14A 2c12C-4krcB:
undetectable		 2c12C-4krcB:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l4x AMPHI

(Streptomyces
nodosus) 		PF08659
(KR) 		5 LEU A 156
VAL A 162
ALA A 163
LEU A 164
VAL A 201
 None
 1.10A 2c12C-4l4xA:
undetectable		 2c12C-4l4xA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1a UNCHARACTERIZED
PROTEIN

(Ruminiclostridium
thermocellum) 		PF13200
(DUF4015) 		5 LEU A 188
VAL A 143
ALA A 142
LEU A 181
VAL A 180
 None
 1.16A 2c12C-4s1aA:
undetectable		 2c12C-4s1aA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tkm NADH-DEPENDENT
REDUCTASE FOR
4-DEOXY-L-ERYTHRO-5-
HEXOSEULOSE URONATE

(Sphingomonas
sp. A1) 		PF13561
(adh_short_C2) 		5 MET A 124
LEU A  75
ALA A  93
SER A  38
VAL A  40
 None
None
SO4  A 304 ( 4.0A)
SO4  A 304 (-3.3A)
None
 1.22A 2c12C-4tkmA:
undetectable		 2c12C-4tkmA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uqg DNA POLYMERASE

(Geobacillus
stearothermophilus) 		PF00476
(DNA_pol_A) 		5 LEU A 485
ALA A 609
LEU A 610
SER A 617
LEU A 616
 None
SUC  A 877 ( 4.0A)
None
None
None
 1.23A 2c12C-4uqgA:
3.4		 2c12C-4uqgA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B

(Roseobacter
denitrificans) 		PF00115
(COX1) 		5 LEU A 209
ALA A 305
LEU A 304
SER A 345
VAL A 344
 None
 1.20A 2c12C-4xydA:
3.7		 2c12C-4xydA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE

(Neurospora
crassa) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		5 LEU A 187
VAL A 221
ALA A 224
SER A 165
LEU A 167
 None
 1.24A 2c12C-4ztxA:
undetectable		 2c12C-4ztxA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyr RNA-DEPENDENT RNA
POLYMERASE

(Thosea asigna
virus) 		no annotation 5 LEU B 201
ALA B 291
LEU B 289
LEU B 236
VAL B 235
 None
 1.04A 2c12C-5cyrB:
undetectable		 2c12C-5cyrB:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgq PUTATIVE
ENDOGLUCANASE-RELATE
D PROTEIN

(Photobacterium
profundum) 		PF00759
(Glyco_hydro_9) 		5 GLN A 346
LEU A 342
ALA A 402
LEU A 403
LEU A 379
 None
 1.13A 2c12C-5dgqA:
undetectable		 2c12C-5dgqA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6s INTEGRIN ALPHA-L

(Homo sapiens) 		PF00092
(VWA)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		5 LEU A 111
ALA A  75
LEU A 333
SER A  82
ASP A  80
 None
 1.03A 2c12C-5e6sA:
undetectable		 2c12C-5e6sA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ere EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Desulfohalobium
retbaense) 		PF13458
(Peripla_BP_6) 		5 LEU A 293
GLU A 289
LEU A 128
LEU A 139
ASP A 334
 None
 1.19A 2c12C-5ereA:
undetectable		 2c12C-5ereA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h29 THIOREDOXIN
REDUCTASE/GLUTATHION
E-RELATED PROTEIN

(Enterococcus
faecalis) 		no annotation 5 GLN A 504
LEU A 376
LEU A 457
LEU A 455
VAL A 452
 None
 1.24A 2c12C-5h29A:
undetectable		 2c12C-5h29A:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy4 RING-OPENING
AMIDOHYDROLASE

(Frankia sp.
Eul1b) 		PF09663
(Amido_AtzD_TrzD) 		6 GLN A 113
LEU A 262
ALA A  18
LEU A 274
MET A  20
LEU A 264
 None
 1.17A 2c12C-5hy4A:
undetectable		 2c12C-5hy4A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iuy MULTIDRUG EFFLUX
OUTER MEMBRANE
PROTEIN OPRN

(Pseudomonas
aeruginosa) 		PF02321
(OEP) 		5 GLN A 232
LEU A 241
LEU A 229
LEU A  46
VAL A  47
 None
 1.12A 2c12C-5iuyA:
undetectable		 2c12C-5iuyA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jig UBIQUITIN AND WLM
DOMAIN-CONTAINING
METALLOPROTEASE
SPCC1442.07C

(Schizosaccharomyces
pombe) 		PF08325
(WLM) 		5 MET A  37
LEU A  99
LEU A  24
LEU A  95
VAL A  91
 None
 1.14A 2c12C-5jigA:
undetectable		 2c12C-5jigA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbg GENERAL SECRETION
PATHWAY PROTEIN F

(Dickeya
dadantii) 		no annotation 5 LEU A  87
ALA A 121
MET A 124
LEU A 148
VAL A 151
 None
 1.21A 2c12C-5nbgA:
undetectable		 2c12C-5nbgA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u56 MACROPHAGE GROWTH
LOCUS A

(Francisella
tularensis) 		PF13417
(GST_N_3) 		5 LEU A  75
ALA A  26
LEU A   2
SER A  56
LEU A  55
 None
 1.20A 2c12C-5u56A:
undetectable		 2c12C-5u56A:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8s DNA REPLICATION
LICENSING FACTOR
MCM4

(Saccharomyces
cerevisiae) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		5 GLN 4 876
LEU 4 919
VAL 4 872
LEU 4 873
SER 4 926
 None
 1.19A 2c12C-5u8s4:
undetectable		 2c12C-5u8s4:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj7 ORIGIN RECOGNITION
COMPLEX SUBUNIT 5

(Homo sapiens) 		PF13191
(AAA_16)
PF14630
(ORC5_C) 		5 LEU E 187
ALA E 229
LEU E 228
LEU E 212
VAL E 214
 None
 1.06A 2c12C-5uj7E:
undetectable		 2c12C-5uj7E:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujm ORIGIN RECOGNITION
COMPLEX SUBUNIT 5

(Homo sapiens) 		PF13191
(AAA_16)
PF14630
(ORC5_C) 		5 LEU E 187
ALA E 229
LEU E 228
LEU E 212
VAL E 214
 None
 1.05A 2c12C-5ujmE:
undetectable		 2c12C-5ujmE:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyw PYRUVATE CARBOXYLASE

(Lactococcus
lactis) 		PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 LEU A 539
VAL A 802
SER A 761
LEU A 762
ASP A 796
 None
 1.15A 2c12C-5vywA:
undetectable		 2c12C-5vywA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6o SERINE/THREONINE-PRO
TEIN KINASE MEC1

(Saccharomyces
cerevisiae) 		no annotation 5 GLN C1695
GLU C1724
LEU C1693
SER C1709
LEU C1710
 None
 0.90A 2c12C-5x6oC:
undetectable		 2c12C-5x6oC:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xe7 ECF RNA POLYMERASE
SIGMA FACTOR SIGJ

(Mycobacterium
tuberculosis) 		PF04542
(Sigma70_r2)
PF08281
(Sigma70_r4_2)
PF12680
(SnoaL_2) 		5 LEU A  64
ALA A 120
LEU A 123
SER A  57
LEU A  61
 None
 1.14A 2c12C-5xe7A:
undetectable		 2c12C-5xe7A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r X-RAY REPAIR
CROSS-COMPLEMENTING
PROTEIN 6

(Homo sapiens) 		PF02735
(Ku)
PF03730
(Ku_C)
PF03731
(Ku_N) 		5 LEU A 495
GLU A 491
LEU A 243
SER A  69
VAL A  70
 None
 1.16A 2c12C-5y3rA:
undetectable		 2c12C-5y3rA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c08 SODIUM-COUPLED
NEUTRAL AMINO ACID
TRANSPORTER 9

(Danio rerio) 		no annotation 5 MET C 118
LEU C 383
SER C 382
LEU C 381
VAL C 378
 None
 1.12A 2c12C-6c08C:
3.2		 2c12C-6c08C:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0w HISTONE H3-LIKE
CENTROMERIC PROTEIN
A
HISTONE H4

(Homo sapiens) 		no annotation 5 LEU B  58
ALA B  33
LEU A  61
LEU A 102
VAL A 103
 LEU  B  58 ( 0.6A)
ALA  B  33 ( 0.0A)
LEU  A  61 ( 0.6A)
LEU  A 102 ( 0.6A)
VAL  A 103 ( 0.6A)
 1.05A 2c12C-6c0wB:
undetectable		 2c12C-6c0wB:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
BETA

(Pyrococcus
furiosus) 		no annotation 5 GLN L  49
MET K 120
LEU K 136
VAL L  48
LEU L  45
 None
 1.22A 2c12C-6cfwL:
undetectable		 2c12C-6cfwL:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dku VP35

(Myotis
lucifugus) 		no annotation 5 LEU A 262
VAL A 199
ALA A 200
LEU A 197
SER A 191
 None
 1.09A 2c12C-6dkuA:
undetectable		 2c12C-6dkuA:
undetectable