SIMILAR PATTERNS OF AMINO ACIDS FOR 2BYT_D_LEUD1601

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eg1 ENDOGLUCANASE I

(Trichoderma
reesei) 		PF00840
(Glyco_hydro_7) 		4 TYR A  38
ASP A  35
TYR A 170
TYR A 146
 None
 1.30A 2bytD-1eg1A:
undetectable		 2bytD-1eg1A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h76 SEROTRANSFERRIN

(Sus scrofa) 		PF00405
(Transferrin) 		4 TYR A 399
TYR A 526
TYR A 431
HIS A 594
 None
CO3  A 701 ( 3.9A)
FE  A 703 ( 4.2A)
FE  A 703 ( 3.4A)
 1.50A 2bytD-1h76A:
undetectable		 2bytD-1h76A:
21.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1obh LEUCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2)
PF14795
(Leucyl-specific) 		6 MET A  40
TYR A  43
ASP A  80
TYR A 507
TYR A 535
HIS A 545
 LMS  A1817 ( 3.7A)
NVA  A1816 ( 3.5A)
NVA  A1816 (-3.9A)
None
None
NVA  A1816 (-3.5A)
 0.35A 2bytD-1obhA:
38.6		 2bytD-1obhA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pg7 HUMANIZED ANTIBODY
D3H44
MURINE ANTIBODY 6A6
FAB FRAGMENT

(Homo sapiens;
Mus musculus;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		4 TYR H  33
ASP H  52
TYR X 102
HIS X  32
 None
 1.45A 2bytD-1pg7H:
0.0		 2bytD-1pg7H:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pn4 PEROXISOMAL
HYDRATASE-DEHYDROGEN
ASE-EPIMERASE

(Candida
tropicalis) 		PF01575
(MaoC_dehydratas) 		4 MET A 206
ASP A 182
TYR A 177
HIS A  46
 None
HDC  A1277 (-2.8A)
None
None
 1.36A 2bytD-1pn4A:
undetectable		 2bytD-1pn4A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8q GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PERIPLASMIC

(Escherichia
coli) 		PF03009
(GDPD) 		4 TYR A 238
ASP A 280
TYR A 281
TYR A 323
 None
 1.42A 2bytD-1t8qA:
undetectable		 2bytD-1t8qA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tz7 4-ALPHA-GLUCANOTRANS
FERASE

(Aquifex
aeolicus) 		PF02446
(Glyco_hydro_77) 		4 TYR A  58
ASP A 286
TYR A 380
HIS A 384
 None
 1.48A 2bytD-1tz7A:
0.0		 2bytD-1tz7A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v26 LONG-CHAIN-FATTY-ACI
D-COA SYNTHETASE

(Thermus
thermophilus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 MET A 228
TYR A  89
HIS A  82
HIS A  85
 None
 1.47A 2bytD-1v26A:
0.0		 2bytD-1v26A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wza ALPHA-AMYLASE A

(Halothermothrix
orenii) 		PF00128
(Alpha-amylase) 		4 MET A  82
TYR A  90
TYR A  93
HIS A 329
 None
 1.17A 2bytD-1wzaA:
undetectable		 2bytD-1wzaA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x79 ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA1

(Homo sapiens) 		PF03127
(GAT) 		4 MET A 249
ASP A 247
TYR A 294
HIS A 235
 None
 1.17A 2bytD-1x79A:
3.9		 2bytD-1x79A:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zh8 OXIDOREDUCTASE

(Thermotoga
maritima) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 ASP A 186
TYR A 240
TYR A 236
HIS A 191
 NAP  A 400 ( 4.7A)
None
None
None
 1.14A 2bytD-1zh8A:
undetectable		 2bytD-1zh8A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE

(Desulfovibrio
africanus) 		PF01558
(POR)
PF01855
(POR_N)
PF02775
(TPP_enzyme_C)
PF10371
(EKR)
PF13484
(Fer4_16)
PF17147
(PFOR_II) 		4 MET A 276
ASP A 328
TYR A 363
HIS A 127
 None
 1.44A 2bytD-2c3oA:
undetectable		 2bytD-2c3oA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c6x CITRATE SYNTHASE 1

(Bacillus
subtilis) 		PF00285
(Citrate_synt) 		4 TYR A 255
ASP A 259
TYR A  28
HIS A 178
 None
None
None
CIT  A1366 (-3.0A)
 1.47A 2bytD-2c6xA:
undetectable		 2bytD-2c6xA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cn3 BETA-1,4-XYLOGLUCAN
HYDROLASE

(Ruminiclostridium
thermocellum) 		PF02012
(BNR) 		4 TYR A 608
ASP A 600
TYR A 692
HIS A 649
 None
 1.30A 2bytD-2cn3A:
undetectable		 2bytD-2cn3A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f7l 455AA LONG
HYPOTHETICAL
PHOSPHO-SUGAR MUTASE

(Sulfurisphaera
tokodaii) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 MET A 344
TYR A 155
HIS A 162
HIS A 336
 None
 1.44A 2bytD-2f7lA:
undetectable		 2bytD-2f7lA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hdw HYPOTHETICAL PROTEIN
PA2218

(Pseudomonas
aeruginosa) 		PF02129
(Peptidase_S15) 		4 ASP A 262
TYR A 263
TYR A 204
HIS A 318
 None
 1.08A 2bytD-2hdwA:
undetectable		 2bytD-2hdwA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2icw MYCOPLASMA
ARTHRITIDIS MITOGEN
T-CELL RECEPTOR BETA
CHAIN V

(Mycoplasma
arthritidis;
Mus musculus) 		PF09245
(MA-Mit)
PF07686
(V-set) 		4 TYR J  33
TYR J 100
TYR G 188
HIS J  29
 None
 1.31A 2bytD-2icwJ:
undetectable		 2bytD-2icwJ:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2il5 HYPOTHETICAL PROTEIN

(Staphylococcus
aureus) 		PF08327
(AHSA1) 		4 MET A  89
TYR A 121
ASP A 101
TYR A  60
 None
 1.48A 2bytD-2il5A:
undetectable		 2bytD-2il5A:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ja2 GLUTAMYL-TRNA
SYNTHETASE

(Mycobacterium
tuberculosis) 		PF00749
(tRNA-synt_1c) 		4 ASP A 133
TYR A 132
TYR A 108
HIS A 138
 None
 1.41A 2bytD-2ja2A:
14.2		 2bytD-2ja2A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oqh PUTATIVE ISOMERASE

(Streptomyces
coelicolor) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ASP A 197
TYR A 221
HIS A 297
HIS A 268
 None
 1.13A 2bytD-2oqhA:
undetectable		 2bytD-2oqhA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwg SORTASE

(Actinomyces
oris) 		PF04203
(Sortase) 		4 MET A 149
TYR A 118
HIS A 184
HIS A 171
 None
 1.37A 2bytD-2xwgA:
undetectable		 2bytD-2xwgA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b4v FOLLISTATIN-LIKE 3

(Homo sapiens) 		PF07648
(Kazal_2)
PF09289
(FOLN) 		4 MET C 136
ASP C 112
TYR C 137
HIS C 165
 None
 1.46A 2bytD-3b4vC:
undetectable		 2bytD-3b4vC:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bg9 PYRUVATE
CARBOXYLASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		4 MET A1012
ASP A 613
TYR A 651
TYR A 654
 None
 1.38A 2bytD-3bg9A:
undetectable		 2bytD-3bg9A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c2u XYLOSIDASE/ARABINOSI
DASE

(Selenomonas
ruminantium) 		PF04616
(Glyco_hydro_43)
PF07081
(DUF1349) 		4 TYR A 139
ASP A 133
TYR A 224
HIS A 221
 None
 1.31A 2bytD-3c2uA:
undetectable		 2bytD-3c2uA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fez UNCHARACTERIZED
FERREDOXIN FOLD
PROTEIN RELATED TO
ANTIBIOTIC
BIOSYNTHESIS
MONOOXYGENASES

(Listeria
monocytogenes) 		no annotation 4 TYR A 157
ASP A 155
TYR A  72
TYR A  53
 None
 1.08A 2bytD-3fezA:
undetectable		 2bytD-3fezA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ga3 INTERFERON-INDUCED
HELICASE C
DOMAIN-CONTAINING
PROTEIN 1, MDA5

(Homo sapiens) 		PF11648
(RIG-I_C-RD) 		4 MET A 972
TYR A1015
ASP A 953
HIS A 927
 None
 1.40A 2bytD-3ga3A:
undetectable		 2bytD-3ga3A:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s99 BASIC MEMBRANE
LIPOPROTEIN

(Brucella
abortus) 		PF02608
(Bmp) 		4 TYR A  91
TYR A 122
TYR A 253
HIS A  40
 None
 1.22A 2bytD-3s99A:
undetectable		 2bytD-3s99A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w36 NAPH1

(Streptomyces
sp. CNQ525) 		no annotation 4 MET A 161
ASP A 167
HIS A 143
HIS A 140
 None
 1.27A 2bytD-3w36A:
undetectable		 2bytD-3w36A:
19.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ziu LEUCYL-TRNA
SYNTHETASE

(Mycoplasma
mobile) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		7 MET A  43
TYR A  46
ASP A  84
TYR A 327
TYR A 361
HIS A 367
HIS A 371
 LSS  A1638 (-3.9A)
LSS  A1638 (-3.3A)
LSS  A1638 (-3.7A)
LSS  A1638 (-4.8A)
None
LSS  A1638 (-3.8A)
LSS  A1638 (-3.7A)
 0.46A 2bytD-3ziuA:
44.4		 2bytD-3ziuA:
32.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ziu LEUCYL-TRNA
SYNTHETASE

(Mycoplasma
mobile) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		4 TYR A 327
TYR A  46
HIS A 371
HIS A 367
 LSS  A1638 (-4.8A)
LSS  A1638 (-3.3A)
LSS  A1638 (-3.7A)
LSS  A1638 (-3.8A)
 0.87A 2bytD-3ziuA:
44.4		 2bytD-3ziuA:
32.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ziu LEUCYL-TRNA
SYNTHETASE

(Mycoplasma
mobile) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1) 		4 TYR A 361
TYR A  46
HIS A 371
HIS A 367
 None
LSS  A1638 (-3.3A)
LSS  A1638 (-3.7A)
LSS  A1638 (-3.8A)
 1.30A 2bytD-3ziuA:
44.4		 2bytD-3ziuA:
32.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a35 MITOCHONDRIAL
ENOLASE SUPERFAMILY
MEMBER 1

(Homo sapiens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 TYR A  96
ASP A 155
TYR A 158
HIS A 116
 None
EDO  A1452 ( 4.9A)
None
None
 1.49A 2bytD-4a35A:
undetectable		 2bytD-4a35A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aee ALPHA AMYLASE,
CATALYTIC REGION

(Staphylothermus
marinus) 		PF00128
(Alpha-amylase) 		4 TYR A 489
TYR A 283
TYR A 296
HIS A 535
 None
 1.22A 2bytD-4aeeA:
undetectable		 2bytD-4aeeA:
21.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4arc LEUCINE--TRNA LIGASE

(Escherichia
coli) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2) 		7 MET A  40
TYR A  43
ASP A  80
TYR A 499
TYR A 527
HIS A 533
HIS A 537
 LEU  A1001 ( 4.3A)
LEU  A1001 (-3.5A)
LEU  A1001 (-3.9A)
None
None
LEU  A1001 (-4.2A)
LEU  A1001 (-3.6A)
 0.74A 2bytD-4arcA:
34.8		 2bytD-4arcA:
45.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4are COLLAGENASE G

(Hathewaya
histolytica) 		PF01752
(Peptidase_M9)
PF08453
(Peptidase_M9_N) 		4 TYR A 764
ASP A 456
TYR A 533
TYR A 528
 None
 1.50A 2bytD-4areA:
2.5		 2bytD-4areA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4inz SOLUBLE EPOXIDE
HYDROLASE

(Bacillus
megaterium) 		PF00561
(Abhydrolase_1) 		4 ASP A 183
TYR A 187
HIS A  39
HIS A 271
 None
 1.41A 2bytD-4inzA:
undetectable		 2bytD-4inzA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kia LMO2213 PROTEIN

(Listeria
monocytogenes) 		no annotation 4 TYR A 157
ASP A 155
TYR A  72
TYR A  53
 None
 1.17A 2bytD-4kiaA:
undetectable		 2bytD-4kiaA:
11.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ah5 LEUCINE--TRNA LIGASE

(Agrobacterium
tumefaciens) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2) 		7 MET A  38
TYR A  41
ASP A  78
TYR A 496
TYR A 523
HIS A 529
HIS A 533
 LSS  A1818 (-3.9A)
LSS  A1818 (-3.1A)
LSS  A1818 (-3.6A)
None
None
LSS  A1818 (-4.0A)
LSS  A1818 (-3.6A)
 0.30A 2bytD-5ah5A:
47.1		 2bytD-5ah5A:
41.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ah5 LEUCINE--TRNA LIGASE

(Agrobacterium
tumefaciens) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2) 		4 TYR A 496
TYR A  41
HIS A 533
HIS A 529
 None
LSS  A1818 (-3.1A)
LSS  A1818 (-3.6A)
LSS  A1818 (-4.0A)
 0.82A 2bytD-5ah5A:
47.1		 2bytD-5ah5A:
41.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ah5 LEUCINE--TRNA LIGASE

(Agrobacterium
tumefaciens) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2) 		4 TYR A 523
TYR A  41
HIS A 533
HIS A 529
 None
LSS  A1818 (-3.1A)
LSS  A1818 (-3.6A)
LSS  A1818 (-4.0A)
 1.47A 2bytD-5ah5A:
47.1		 2bytD-5ah5A:
41.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cd2 ENDO-1,4-D-GLUCANASE

(Aliivibrio
fischeri) 		PF01270
(Glyco_hydro_8) 		4 TYR A 203
ASP A 136
TYR A  79
TYR A 359
 None
GOL  A 402 (-2.9A)
None
None
 1.32A 2bytD-5cd2A:
0.9		 2bytD-5cd2A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gy3 GLUCANASE

(Klebsiella
pneumoniae) 		PF01270
(Glyco_hydro_8) 		4 TYR A 175
ASP A 110
TYR A 316
HIS A  51
 None
 1.29A 2bytD-5gy3A:
2.4		 2bytD-5gy3A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01266
(DAO)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF16350
(FAO_M) 		4 TYR A 299
TYR A 399
TYR A 374
HIS A 270
 None
None
None
FAD  A 901 (-4.8A)
 1.20A 2bytD-5l46A:
undetectable		 2bytD-5l46A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq8 PUTATIVE PHOSPHONATE
BINDING PROTEIN FOR
ABC TRANSPORTER

(Prochlorococcus
marinus) 		no annotation 4 TYR A 206
ASP A 205
TYR A 203
HIS A 158
 GB  A 401 (-3.2A)
GB  A 401 (-2.7A)
None
GB  A 401 (-4.0A)
 1.21A 2bytD-5lq8A:
undetectable		 2bytD-5lq8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m99 ALPHA-AMYLASE

(Thermotoga
petrophila) 		PF00128
(Alpha-amylase) 		4 MET B  72
TYR B  80
TYR B  83
HIS B 304
 None
None
K  B 605 ( 3.2A)
None
 1.10A 2bytD-5m99B:
undetectable		 2bytD-5m99B:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oyn DEHYDRATASE,
ILVD/EDD FAMILY

(Caulobacter
vibrioides) 		no annotation 4 MET A  23
ASP A  19
TYR A  27
HIS A 589
 None
 1.28A 2bytD-5oynA:
undetectable		 2bytD-5oynA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0a GLUCANASE

(Trichoderma
harzianum) 		no annotation 4 TYR A  38
ASP A  35
TYR A 170
TYR A 146
 TYR  A  38 ( 1.3A)
ASP  A  35 ( 0.6A)
TYR  A 170 ( 1.3A)
TYR  A 146 ( 1.3A)
 1.29A 2bytD-5w0aA:
undetectable		 2bytD-5w0aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wzr ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Bifidobacterium
bifidum) 		PF11308
(Glyco_hydro_129) 		4 TYR A 329
ASP A 322
TYR A 550
HIS A 492
 DJN  A 702 (-4.2A)
CA  A 703 (-2.1A)
None
DJN  A 702 (-3.5A)
 1.48A 2bytD-5wzrA:
undetectable		 2bytD-5wzrA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoq DIPEPTIDYL PEPTIDASE
9

(Homo sapiens) 		no annotation 4 TYR A 762
ASP A 763
HIS A 815
HIS A 812
 None
 1.27A 2bytD-6eoqA:
undetectable		 2bytD-6eoqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f79 -

(-) 		no annotation 4 ASP A 260
TYR A 149
HIS A  69
HIS A  68
 0X9  A 407 (-4.3A)
None
ZN  A 401 ( 3.1A)
None
 1.26A 2bytD-6f79A:
undetectable		 2bytD-6f79A:
undetectable