SIMILAR PATTERNS OF AMINO ACIDS FOR 2BYO_A_LNLA1217

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6d THERMOSOME (ALPHA
SUBUNIT)


(Thermoplasma
acidophilum)
PF00118
(Cpn60_TCP1)
4 VAL A 231
LEU A 336
ILE A 239
LEU A 238
None
0.87A 2byoA-1a6dA:
0.0
2byoA-1a6dA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1asx THERMOSOME

(Thermoplasma
acidophilum)
PF00118
(Cpn60_TCP1)
4 VAL A  19
LEU A 124
ILE A  27
LEU A  26
None
0.78A 2byoA-1asxA:
undetectable
2byoA-1asxA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bp1 BACTERICIDAL/PERMEAB
ILITY-INCREASING
PROTEIN


(Homo sapiens)
PF01273
(LBP_BPI_CETP)
PF02886
(LBP_BPI_CETP_C)
4 VAL A 254
LEU A 186
ILE A 130
LEU A  76
PC1  A 777 (-4.8A)
PC1  A 777 (-4.7A)
None
None
1.04A 2byoA-1bp1A:
2.3
2byoA-1bp1A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gns SUBTILISIN BPN'

(Bacillus
amyloliquefaciens)
PF00082
(Peptidase_S8)
4 VAL A  30
LEU A 250
ILE A 234
LEU A 233
None
1.03A 2byoA-1gnsA:
0.0
2byoA-1gnsA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gxl CHROMOSOME
SEGREGATION SMC
PROTEIN


(Thermotoga
maritima)
PF06470
(SMC_hinge)
4 VAL A 503
LEU A 613
ILE A 524
LEU A 523
None
1.00A 2byoA-1gxlA:
0.0
2byoA-1gxlA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2b ALCOHOL
DEHYDROGENASE


(Aeropyrum
pernix)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
4 VAL A 351
LEU A 336
ILE A  30
LEU A  28
None
1.02A 2byoA-1h2bA:
0.0
2byoA-1h2bA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ii0 ARSENICAL
PUMP-DRIVING ATPASE


(Escherichia
coli)
PF02374
(ArsA_ATPase)
4 VAL A  68
LEU A  11
ILE A   7
LEU A   4
None
1.02A 2byoA-1ii0A:
0.0
2byoA-1ii0A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7j PROTEIN YCIO

(Escherichia
coli)
PF01300
(Sua5_yciO_yrdC)
4 VAL A 184
LEU A 141
ILE A  53
LEU A  59
None
0.96A 2byoA-1k7jA:
0.0
2byoA-1k7jA:
24.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nbw GLYCEROL DEHYDRATASE
REACTIVASE ALPHA
SUBUNIT


(Klebsiella
pneumoniae)
PF08841
(DDR)
4 VAL A 201
LEU A 121
ILE A 158
LEU A 154
None
0.91A 2byoA-1nbwA:
0.0
2byoA-1nbwA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ohe CDC14B2 PHOSPHATASE

(Homo sapiens)
PF00782
(DSPc)
PF14671
(DSPn)
4 VAL A 344
LEU A 283
ILE A 302
LEU A 300
None
0.88A 2byoA-1oheA:
undetectable
2byoA-1oheA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3s THERMOSOME ALPHA
SUBUNIT


(Thermococcus
sp. JCM 11816)
PF00118
(Cpn60_TCP1)
4 VAL A 234
LEU A 339
ILE A 242
LEU A 241
None
0.82A 2byoA-1q3sA:
undetectable
2byoA-1q3sA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qcq PROTEIN (UBIQUITIN
CONJUGATING ENZYME)


(Saccharomyces
cerevisiae)
PF00179
(UQ_con)
4 VAL A 121
LEU A  53
ILE A 107
LEU A 111
None
1.00A 2byoA-1qcqA:
0.8
2byoA-1qcqA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rrh SEED LIPOXYGENASE-3

(Glycine max)
PF00305
(Lipoxygenase)
PF01477
(PLAT)
4 VAL A 571
LEU A 343
ILE A 325
LEU A 331
None
0.95A 2byoA-1rrhA:
undetectable
2byoA-1rrhA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 40 KDA
SUBUNIT


(Saccharomyces
cerevisiae)
PF13177
(DNA_pol3_delta2)
4 VAL E 116
LEU E  36
ILE E  60
LEU E  57
None
0.95A 2byoA-1sxjE:
undetectable
2byoA-1sxjE:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1td2 PYRIDOXAMINE KINASE

(Escherichia
coli)
PF08543
(Phos_pyr_kin)
4 VAL A 114
LEU A   6
ILE A  96
LEU A  60
None
0.85A 2byoA-1td2A:
undetectable
2byoA-1td2A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wix HOOK HOMOLOG 1

(Mus musculus)
PF05622
(HOOK)
4 VAL A  63
LEU A  43
ILE A 120
LEU A 116
None
0.98A 2byoA-1wixA:
undetectable
2byoA-1wixA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdp POLYPHOSPHATE KINASE

(Escherichia
coli)
PF02503
(PP_kinase)
PF13089
(PP_kinase_N)
PF13090
(PP_kinase_C)
4 VAL A 159
LEU A 123
ILE A 197
LEU A 199
None
0.70A 2byoA-1xdpA:
undetectable
2byoA-1xdpA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ye8 HYPOTHETICAL UPF0334
KINASE-LIKE PROTEIN
AQ_1292


(Aquifex
aeolicus)
PF03266
(NTPase_1)
4 VAL A 102
LEU A 160
ILE A 168
LEU A 169
None
1.04A 2byoA-1ye8A:
undetectable
2byoA-1ye8A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A


(Homo sapiens)
PF00233
(PDEase_I)
4 VAL A 151
LEU A 194
ILE A 184
LEU A 183
None
0.82A 2byoA-1zklA:
undetectable
2byoA-1zklA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c81 GLUTAMINE-2-DEOXY-SC
YLLO-INOSOSE
AMINOTRANSFERASE


(Bacillus
circulans)
PF01041
(DegT_DnrJ_EryC1)
4 VAL A  85
LEU A 216
ILE A 213
LEU A 209
None
1.03A 2byoA-2c81A:
undetectable
2byoA-2c81A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE


(Escherichia
coli)
PF01557
(FAA_hydrolase)
4 VAL A 207
LEU A 173
ILE A 234
LEU A  83
None
1.05A 2byoA-2eb5A:
undetectable
2byoA-2eb5A:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fia ACETYLTRANSFERASE

(Enterococcus
faecalis)
PF00583
(Acetyltransf_1)
4 VAL A  21
LEU A 100
ILE A   3
LEU A  54
None
1.04A 2byoA-2fiaA:
undetectable
2byoA-2fiaA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gas ISOFLAVONE REDUCTASE

(Medicago sativa)
PF05368
(NmrA)
4 VAL A  21
LEU A  81
ILE A 106
LEU A  98
None
0.98A 2byoA-2gasA:
undetectable
2byoA-2gasA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ha8 TAR (HIV-1) RNA LOOP
BINDING PROTEIN


(Homo sapiens)
PF00588
(SpoU_methylase)
4 VAL A 160
LEU A  93
ILE A 103
LEU A 143
SAH  A 401 (-3.6A)
None
None
None
1.03A 2byoA-2ha8A:
undetectable
2byoA-2ha8A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nm0 PROBABLE
3-OXACYL-(ACYL-CARRI
ER-PROTEIN)
REDUCTASE


(Streptomyces
coelicolor)
PF13561
(adh_short_C2)
4 VAL A  55
LEU A 115
ILE A 163
LEU A 154
None
0.92A 2byoA-2nm0A:
undetectable
2byoA-2nm0A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r0j UBIQUITIN CARRIER
PROTEIN


(Plasmodium
falciparum)
PF00179
(UQ_con)
4 VAL A 123
LEU A  52
ILE A 106
LEU A 110
None
1.04A 2byoA-2r0jA:
undetectable
2byoA-2r0jA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rds FE(II)/ALPHA-KETOGL
UTARATE DEPENDENT
HYDROXYLASE
1-DEOXYPENTALENIC
ACID 11-BETA
HYDROXYLASE


(Streptomyces
avermitilis)
PF05721
(PhyH)
4 VAL A  76
LEU A  65
ILE A 157
LEU A 156
None
0.93A 2byoA-2rdsA:
undetectable
2byoA-2rdsA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgy TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY


(Paraburkholderia
phymatum)
PF13377
(Peripla_BP_3)
4 VAL A 349
LEU A 231
ILE A 201
LEU A 200
None
0.96A 2byoA-2rgyA:
undetectable
2byoA-2rgyA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vf8 EXCINUCLEASE ABC
SUBUNIT A


(Deinococcus
radiodurans)
PF00005
(ABC_tran)
4 VAL A 508
LEU A 522
ILE A 583
LEU A 580
None
1.05A 2byoA-2vf8A:
undetectable
2byoA-2vf8A:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbl RAC-LIKE GTP-BINDING
PROTEIN ARAC2


(Arabidopsis
thaliana)
PF00071
(Ras)
4 VAL C 176
LEU C 146
ILE C  96
LEU C 101
None
0.96A 2byoA-2wblC:
undetectable
2byoA-2wblC:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3awd PUTATIVE POLYOL
DEHYDROGENASE


(Gluconobacter
oxydans)
PF13561
(adh_short_C2)
4 VAL A  74
LEU A 135
ILE A 185
LEU A 176
None
0.82A 2byoA-3awdA:
undetectable
2byoA-3awdA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dg7 MUCONATE
CYCLOISOMERASE


(Mycolicibacterium
smegmatis)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 VAL A 118
LEU A  33
ILE A 355
LEU A 332
None
1.03A 2byoA-3dg7A:
undetectable
2byoA-3dg7A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dm8 UNCHARACTERIZED
PROTEIN RPA4348


(Rhodopseudomonas
palustris)
PF12680
(SnoaL_2)
4 VAL A  88
LEU A  25
ILE A  28
LEU A 116
None
0.83A 2byoA-3dm8A:
undetectable
2byoA-3dm8A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ezy DEHYDROGENASE

(Thermotoga
maritima)
PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C)
4 VAL A 114
LEU A  57
ILE A   6
LEU A  67
None
1.01A 2byoA-3ezyA:
undetectable
2byoA-3ezyA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hp0 PUTATIVE POLYKETIDE
BIOSYNTHESIS
ENOYL-COA HYDRATASE
HOMOLOG PKSH


(Bacillus
subtilis)
PF00378
(ECH_1)
4 VAL A 111
LEU A  92
ILE A  36
LEU A  35
None
0.96A 2byoA-3hp0A:
undetectable
2byoA-3hp0A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l9c 3-DEHYDROQUINATE
DEHYDRATASE


(Streptococcus
mutans)
PF01487
(DHquinase_I)
4 VAL A  44
LEU A 201
ILE A  23
LEU A  20
None
0.94A 2byoA-3l9cA:
undetectable
2byoA-3l9cA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lbf PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE


(Escherichia
coli)
PF01135
(PCMT)
4 VAL A 197
LEU A  71
ILE A 167
LEU A 168
None
0.94A 2byoA-3lbfA:
undetectable
2byoA-3lbfA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m4x NOL1/NOP2/SUN FAMILY
PROTEIN


(Enterococcus
faecium)
PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N)
PF17126
(RsmF_methylt_CI)
4 VAL A  97
LEU A 146
ILE A 150
LEU A 133
None
1.05A 2byoA-3m4xA:
undetectable
2byoA-3m4xA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mca ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN


(Schizosaccharomyces
pombe)
PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
4 VAL A 283
LEU A 387
ILE A 197
LEU A 194
None
0.98A 2byoA-3mcaA:
undetectable
2byoA-3mcaA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nas BETA-PHOSPHOGLUCOMUT
ASE


(Bacillus
subtilis)
PF13419
(HAD_2)
4 VAL A 188
LEU A 100
ILE A 110
LEU A 112
None
0.99A 2byoA-3nasA:
undetectable
2byoA-3nasA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE


(Lactobacillus
brevis)
PF00348
(polyprenyl_synt)
4 VAL A  89
LEU A  79
ILE A 146
LEU A 147
None
1.03A 2byoA-3pkoA:
undetectable
2byoA-3pkoA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pzr ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE


(Vibrio cholerae)
PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC)
4 VAL A 302
LEU A 282
ILE A 286
LEU A 288
None
1.04A 2byoA-3pzrA:
1.3
2byoA-3pzrA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r6h ENOYL-COA HYDRATASE,
ECHA3


(Mycobacterium
marinum)
PF00378
(ECH_1)
4 VAL A 144
LEU A  49
ILE A  38
LEU A  34
None
1.02A 2byoA-3r6hA:
undetectable
2byoA-3r6hA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rr1 PUTATIVE
D-GALACTONATE
DEHYDRATASE


(Ralstonia
pickettii)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 VAL A  97
LEU A   6
ILE A  86
LEU A  63
None
0.97A 2byoA-3rr1A:
undetectable
2byoA-3rr1A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5w L-ORNITHINE
5-MONOOXYGENASE


(Pseudomonas
aeruginosa)
PF13434
(K_oxygenase)
4 VAL A 147
LEU A  25
ILE A 419
LEU A 423
None
0.76A 2byoA-3s5wA:
undetectable
2byoA-3s5wA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tha TRYPTOPHAN SYNTHASE
ALPHA CHAIN


(Campylobacter
jejuni)
PF00290
(Trp_syntA)
4 VAL A  70
LEU A  88
ILE A 114
LEU A 112
None
0.98A 2byoA-3thaA:
undetectable
2byoA-3thaA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ty2 5'-NUCLEOTIDASE SURE

(Coxiella
burnetii)
PF01975
(SurE)
4 VAL A 117
LEU A 162
ILE A 157
LEU A 153
None
0.80A 2byoA-3ty2A:
undetectable
2byoA-3ty2A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va7 KLLA0E08119P

(Kluyveromyces
lactis)
PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
4 VAL A 917
LEU A1061
ILE A1045
LEU A1042
GOL  A1904 (-3.9A)
None
None
None
1.03A 2byoA-3va7A:
1.5
2byoA-3va7A:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vti HYDROGENASE
MATURATION FACTOR


(Caldanaerobacter
subterraneus)
PF00586
(AIRS)
PF02769
(AIRS_C)
4 VAL C 242
LEU C 224
ILE C 221
LEU C 217
None
1.04A 2byoA-3vtiC:
undetectable
2byoA-3vtiC:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aca TRANSLATION
ELONGATION FACTOR
SELB


(Methanococcus
maripaludis)
PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
4 VAL A  90
LEU A  85
ILE A 169
LEU A 168
None
0.93A 2byoA-4acaA:
undetectable
2byoA-4acaA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ah6 ASPARTATE--TRNA
LIGASE,
MITOCHONDRIAL


(Homo sapiens)
PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD)
4 VAL A 312
LEU A 201
ILE A 283
LEU A 583
None
1.05A 2byoA-4ah6A:
1.2
2byoA-4ah6A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4as3 PHOSPHORYLCHOLINE
PHOSPHATASE


(Pseudomonas
aeruginosa)
no annotation 4 VAL A 321
LEU A 155
ILE A  18
LEU A  17
None
1.04A 2byoA-4as3A:
undetectable
2byoA-4as3A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0j MITOCHONDRIAL RHO
GTPASE


(Drosophila
melanogaster)
PF00071
(Ras)
PF08355
(EF_assoc_1)
PF08356
(EF_assoc_2)
4 VAL A 446
LEU A 388
ILE A 336
LEU A 335
None
0.97A 2byoA-4c0jA:
undetectable
2byoA-4c0jA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2p CYTOCHROME P450
107B1 (P450CVIIB1)


(Streptomyces
himastatinicus)
PF00067
(p450)
4 VAL A  98
LEU A 360
ILE A 245
LEU A 244
None
None
None
HEM  A 401 (-3.6A)
0.91A 2byoA-4e2pA:
undetectable
2byoA-4e2pA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1


(Caenorhabditis
elegans)
PF00005
(ABC_tran)
PF00664
(ABC_membrane)
4 VAL A 470
LEU A 449
ILE A 609
LEU A 577
None
1.04A 2byoA-4f4cA:
undetectable
2byoA-4f4cA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fog THYMIDYLATE SYNTHASE

(Mycobacterium
tuberculosis)
PF00303
(Thymidylat_synt)
4 VAL A 196
LEU A  63
ILE A 112
LEU A 116
None
1.03A 2byoA-4fogA:
undetectable
2byoA-4fogA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gel MITOCHONDRIAL
CARDIOLIPIN
HYDROLASE


(Drosophila
melanogaster)
PF13091
(PLDc_2)
4 VAL A  93
LEU A 152
ILE A 133
LEU A 109
None
0.98A 2byoA-4gelA:
undetectable
2byoA-4gelA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gj4 SOLUBLE GUANYLYL
CYCLASE ALPHA-1
SUBUNIT


(Manduca sexta)
PF07701
(HNOBA)
4 VAL A 281
LEU A 298
ILE A 341
LEU A 342
None
1.00A 2byoA-4gj4A:
undetectable
2byoA-4gj4A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gpv PUTATIVE CELL
ADHESION PROTEIN


(Bacteroides
eggerthii)
PF06321
(P_gingi_FimA)
4 VAL A 343
LEU A 204
ILE A 179
LEU A 181
None
1.00A 2byoA-4gpvA:
undetectable
2byoA-4gpvA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0u THYMIDYLATE SYNTHASE

(Corynebacterium
glutamicum)
PF00303
(Thymidylat_synt)
4 VAL A 199
LEU A  66
ILE A 115
LEU A 119
None
0.98A 2byoA-4h0uA:
undetectable
2byoA-4h0uA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ija XYLR PROTEIN

(Staphylococcus
aureus)
PF00480
(ROK)
PF01047
(MarR)
4 VAL A 176
LEU A 104
ILE A 115
LEU A 113
None
1.01A 2byoA-4ijaA:
undetectable
2byoA-4ijaA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jq9 DIHYDROLIPOYL
DEHYDROGENASE


(Escherichia
coli)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
4 VAL A 221
LEU A 399
ILE A 425
LEU A 421
None
0.80A 2byoA-4jq9A:
undetectable
2byoA-4jq9A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ka8 OLIGOPEPTIDASE A

(Arabidopsis
thaliana)
PF01432
(Peptidase_M3)
4 VAL A 543
LEU A 100
ILE A 164
LEU A 167
None
0.93A 2byoA-4ka8A:
undetectable
2byoA-4ka8A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mrq PHOSPHOMANNOMUTASE/P
HOSPHOGLUCOMUTASE


(Pseudomonas
aeruginosa)
PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III)
4 VAL A  53
LEU A 143
ILE A 138
LEU A 134
None
0.97A 2byoA-4mrqA:
undetectable
2byoA-4mrqA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0r PUTATIVE GLYCOSIDE
HYDROLASE


(Bacteroides
vulgatus)
PF13204
(DUF4038)
PF16586
(DUF5060)
4 VAL A 355
LEU A 430
ILE A 423
LEU A 419
None
1.02A 2byoA-4n0rA:
undetectable
2byoA-4n0rA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n1a CELL
DIVISIONFTSK/SPOIIIE


(Thermomonospora
curvata)
PF01580
(FtsK_SpoIIIE)
4 VAL A 857
LEU A 779
ILE A1036
LEU A 772
None
0.81A 2byoA-4n1aA:
undetectable
2byoA-4n1aA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nh0 CELL
DIVISIONFTSK/SPOIIIE


(Thermomonospora
curvata)
PF01580
(FtsK_SpoIIIE)
4 VAL A 857
LEU A 779
ILE A1036
LEU A 772
None
0.82A 2byoA-4nh0A:
undetectable
2byoA-4nh0A:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5a LACI FAMILY
TRANSCRIPTION
REGULATOR


(Bifidobacterium
animalis)
PF13377
(Peripla_BP_3)
4 VAL A 324
LEU A  96
ILE A  68
LEU A 131
None
0.93A 2byoA-4o5aA:
undetectable
2byoA-4o5aA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p63 PROBABLE
DEOXYHYPUSINE
SYNTHASE


(Pyrococcus
horikoshii)
PF01916
(DS)
4 VAL A 317
LEU A  89
ILE A  86
LEU A  82
None
0.98A 2byoA-4p63A:
undetectable
2byoA-4p63A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2


(Pisum sativum)
PF00223
(PsaA_PsaB)
4 VAL A 408
LEU B 674
ILE A 443
LEU A 446
CLA  A1128 ( 4.6A)
None
None
CLA  A1137 ( 3.6A)
0.99A 2byoA-4rkuA:
undetectable
2byoA-4rkuA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4umv ZINC-TRANSPORTING
ATPASE


(Shigella sonnei)
PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase)
4 VAL A 614
LEU A 427
ILE A 672
LEU A 668
None
0.76A 2byoA-4umvA:
undetectable
2byoA-4umvA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wlh KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 1


(Homo sapiens)
PF00155
(Aminotran_1_2)
4 VAL A 381
LEU A 154
ILE A 321
LEU A 324
None
1.00A 2byoA-4wlhA:
undetectable
2byoA-4wlhA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wp0 KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 1


(Homo sapiens)
PF00155
(Aminotran_1_2)
4 VAL A 381
LEU A 154
ILE A 321
LEU A 324
None
1.05A 2byoA-4wp0A:
undetectable
2byoA-4wp0A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z5p CYTOCHROME P450
HYDROXYLASE


(Streptomyces
atroolivaceus)
PF00067
(p450)
4 VAL A 280
LEU A 372
ILE A 397
LEU A 374
None
1.03A 2byoA-4z5pA:
undetectable
2byoA-4z5pA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zal UBIX

(Pseudomonas
aeruginosa)
PF02441
(Flavoprotein)
4 VAL A 111
LEU A 190
ILE A   7
LEU A   9
None
1.01A 2byoA-4zalA:
undetectable
2byoA-4zalA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zm4 AMINOTRANSFERASE

(Streptomyces
pactum)
PF00202
(Aminotran_3)
4 VAL A  76
LEU A 274
ILE A 104
LEU A 107
None
0.97A 2byoA-4zm4A:
undetectable
2byoA-4zm4A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a42 UNCHARACTERIZED
LIPOPROTEIN YFHM


(Escherichia
coli)
PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF11974
(MG1)
4 VAL A 845
LEU A 303
ILE A 305
LEU A 364
None
0.98A 2byoA-5a42A:
0.6
2byoA-5a42A:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dm3 L-GLUTAMINE
SYNTHETASE


(Chromohalobacter
salexigens)
PF00120
(Gln-synt_C)
4 VAL A  27
LEU A 193
ILE A 216
LEU A 144
None
1.01A 2byoA-5dm3A:
undetectable
2byoA-5dm3A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eso 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE-1-CARBOXYLA
TE SYNTHASE


(Mycobacterium
tuberculosis)
PF02776
(TPP_enzyme_N)
4 VAL A 501
LEU A 524
ILE A 435
LEU A 437
None
0.94A 2byoA-5esoA:
undetectable
2byoA-5esoA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fb3 GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]


(Pyrobaculum
calidifontis)
PF13685
(Fe-ADH_2)
4 VAL A 248
LEU A 332
ILE A 266
LEU A 262
None
1.05A 2byoA-5fb3A:
undetectable
2byoA-5fb3A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ZETA


(Saccharomyces
cerevisiae)
PF00118
(Cpn60_TCP1)
4 VAL z 491
LEU z  97
ILE z 517
LEU z 513
None
1.02A 2byoA-5gw5z:
undetectable
2byoA-5gw5z:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis)
PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
4 VAL A 917
LEU A1061
ILE A1045
LEU A1042
None
1.03A 2byoA-5i8iA:
0.9
2byoA-5i8iA:
7.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j3u PROTEIN KINASE A

(Toxoplasma
gondii)
PF00027
(cNMP_binding)
4 VAL A 371
LEU A 398
ILE A 362
LEU A 361
None
0.99A 2byoA-5j3uA:
undetectable
2byoA-5j3uA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jh1 ALDOSE REDUCTASE,
AKR4C7


(Zea mays)
PF00248
(Aldo_ket_red)
4 VAL A 249
LEU A 230
ILE A 226
LEU A 275
None
0.95A 2byoA-5jh1A:
undetectable
2byoA-5jh1A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjh 4-ALPHA-GLUCANOTRANS
FERASE


(Corynebacterium
glutamicum)
PF02446
(Glyco_hydro_77)
4 VAL A 699
LEU A 562
ILE A 531
LEU A 532
None
1.02A 2byoA-5jjhA:
undetectable
2byoA-5jjhA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tjr METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE


(Pseudomonas sp.
AAC)
PF00171
(Aldedh)
4 VAL A  34
LEU A 211
ILE A 170
LEU A 171
None
0.89A 2byoA-5tjrA:
undetectable
2byoA-5tjrA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ud5 PYRROLYSINE--TRNA
LIGASE


(Methanosarcina
mazei)
no annotation 4 VAL A  74
LEU A   6
ILE A  36
LEU A  46
None
None
None
U  C  44 ( 4.0A)
1.03A 2byoA-5ud5A:
undetectable
2byoA-5ud5A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj8 ORIGIN RECOGNITION
COMPLEX SUBUNIT 3


(Homo sapiens)
PF07034
(ORC3_N)
4 VAL A 376
LEU A 358
ILE A 355
LEU A 402
None
1.05A 2byoA-5uj8A:
undetectable
2byoA-5uj8A:
13.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vbb RNA PSEUDOURIDYLATE
SYNTHASE
DOMAIN-CONTAINING
PROTEIN 1


(Homo sapiens)
PF00849
(PseudoU_synth_2)
4 VAL A 222
LEU A  40
ILE A  29
LEU A  66
None
0.96A 2byoA-5vbbA:
undetectable
2byoA-5vbbA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyd PHOSPHODIESTERASE

(Salpingoeca
rosetta)
no annotation 4 VAL A  49
LEU A 124
ILE A 162
LEU A 163
None
0.95A 2byoA-5vydA:
undetectable
2byoA-5vydA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5whs CATALASE-PEROXIDASE

(Neurospora
crassa)
no annotation 4 VAL A 634
LEU A 706
ILE A 699
LEU A 611
None
0.98A 2byoA-5whsA:
undetectable
2byoA-5whsA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5y PROBABLE ATP-BINDING
COMPONENT OF ABC
TRANSPORTER


(Pseudomonas
aeruginosa)
no annotation 4 VAL B  95
LEU B 183
ILE B 159
LEU B  83
None
0.90A 2byoA-5x5yB:
undetectable
2byoA-5x5yB:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xn6 OS07G0580900 PROTEIN

(Oryza sativa)
PF00348
(polyprenyl_synt)
4 VAL A  60
LEU A 195
ILE A 223
LEU A 296
None
1.05A 2byoA-5xn6A:
undetectable
2byoA-5xn6A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxu RIBOSOMAL PROTEIN
ES17


(Toxoplasma
gondii)
PF00833
(Ribosomal_S17e)
4 VAL R  38
LEU R  71
ILE R  61
LEU R  57
None
1.01A 2byoA-5xxuR:
undetectable
2byoA-5xxuR:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yy8 INFLUENZA VIRUS
NS1A-BINDING PROTEIN


(Homo sapiens)
no annotation 4 VAL A 240
LEU A 227
ILE A 186
LEU A 184
None
0.94A 2byoA-5yy8A:
undetectable
2byoA-5yy8A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bym STEROL-BINDING
PROTEIN


(Saccharomyces
cerevisiae)
no annotation 4 VAL A 117
LEU A   5
ILE A 193
LEU A 189
None
0.92A 2byoA-6bymA:
2.2
2byoA-6bymA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c01 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 3


(Homo sapiens)
no annotation 4 VAL A 517
LEU A 174
ILE A 184
LEU A 187
None
0.99A 2byoA-6c01A:
undetectable
2byoA-6c01A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj PROTEIN CFT1

(Saccharomyces
cerevisiae)
no annotation 4 VAL A 294
LEU A 399
ILE A 394
LEU A 392
None
1.00A 2byoA-6eojA:
undetectable
2byoA-6eojA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g43 PUTATIVE MAJOR
CAPSID PROTEIN


(Cafeteriavirus-dependent
mavirus)
no annotation 4 VAL A 226
LEU A 138
ILE A 123
LEU A 122
None
1.04A 2byoA-6g43A:
undetectable
2byoA-6g43A:
17.35