SIMILAR PATTERNS OF AMINO ACIDS FOR 2BYO_A_LNLA1216
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cqi | PROTEIN(SUCCINYL-COASYNTHETASE BETACHAIN) (Escherichiacoli) |
PF00549(Ligase_CoA)PF08442(ATP-grasp_2) | 4 | LEU B 287ILE B 305LEU B 306SER B 307 | None | 0.96A | 2byoA-1cqiB:0.0 | 2byoA-1cqiB:21.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dcp | DCOH (Rattusnorvegicus) |
PF01329(Pterin_4a) | 4 | LEU A 17ILE A 34LEU A 77SER A 78 | None | 0.98A | 2byoA-1dcpA:undetectable | 2byoA-1dcpA:18.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j1w | ISOCITRATEDEHYDROGENASE (Azotobactervinelandii) |
PF03971(IDH) | 4 | LEU A 663ILE A 25LEU A 23SER A 21 | None | 0.96A | 2byoA-1j1wA:0.0 | 2byoA-1j1wA:15.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q1n | HYPOTHETICALZINC-TYPE ALCOHOLDEHYDROGENASE-LIKEPROTEIN IN PRE5-FET4INTERGENIC REGION (Saccharomycescerevisiae) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 4 | LEU A 311ILE A 153LEU A 157SER A 155 | None | 0.98A | 2byoA-1q1nA:0.0 | 2byoA-1q1nA:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rkv | HOMOSERINE KINASE (Pseudomonasaeruginosa) |
PF12710(HAD) | 4 | LEU A 12ILE A 88LEU A 89SER A 90 | NoneNoneNonePO4 A 320 (-3.0A) | 0.91A | 2byoA-1rkvA:0.0 | 2byoA-1rkvA:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sfx | CONSERVEDHYPOTHETICAL PROTEINAF2008 (Archaeoglobusfulgidus) |
PF01978(TrmB) | 4 | LEU A 54ILE A 24LEU A 27ARG A 31 | None | 0.88A | 2byoA-1sfxA:0.0 | 2byoA-1sfxA:21.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sg9 | HEMK PROTEIN (Thermotogamaritima) |
PF05175(MTS) | 4 | LEU A 181ILE A 194LEU A 195SER A 196 | None | 0.86A | 2byoA-1sg9A:0.0 | 2byoA-1sg9A:20.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u02 | TREHALOSE-6-PHOSPHATE PHOSPHATASERELATED PROTEIN (Thermoplasmaacidophilum) |
PF02358(Trehalose_PPase) | 5 | LEU A 35ILE A 4LEU A 3SER A 2ARG A 172 | None | 1.42A | 2byoA-1u02A:0.0 | 2byoA-1u02A:23.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ud9 | DNA POLYMERASESLIDING CLAMP A (Sulfurisphaeratokodaii) |
PF00705(PCNA_N)PF02747(PCNA_C) | 4 | LEU A 18ILE A 47LEU A 46SER A 45 | None | 0.91A | 2byoA-1ud9A:1.2 | 2byoA-1ud9A:21.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wra | TEICHOIC ACIDPHOSPHORYLCHOLINEESTERASE/CHOLINEBINDING PROTEIN E(CBPE) (Streptococcuspneumoniae) |
PF00753(Lactamase_B) | 4 | LEU A 295ILE A 266LEU A 269SER A 270 | None | 1.00A | 2byoA-1wraA:undetectable | 2byoA-1wraA:23.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z7m | ATPPHOSPHORIBOSYLTRANSFERASE REGULATORYSUBUNIT (Lactococcuslactis) |
PF13393(tRNA-synt_His) | 4 | LEU A 131ILE A 143LEU A 144SER A 145 | None | 1.00A | 2byoA-1z7mA:undetectable | 2byoA-1z7mA:20.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dnc | PYRUVATEDEHYDROGENASEPROTEIN X COMPONENT (Homo sapiens) |
PF00364(Biotin_lipoyl) | 4 | LEU A 53ILE A 79LEU A 78SER A 77 | None | 0.66A | 2byoA-2dncA:undetectable | 2byoA-2dncA:20.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eqx | KELCH REPEAT AND BTBDOMAIN-CONTAININGPROTEIN 4 (Homo sapiens) |
PF07707(BACK) | 4 | LEU A 207ILE A 211LEU A 247SER A 246 | None | 0.80A | 2byoA-2eqxA:undetectable | 2byoA-2eqxA:16.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f8t | ARGONAUTE PROTEIN (Aquifexaeolicus) |
PF02171(Piwi) | 4 | LEU A 407ILE A 395LEU A 394SER A 393 | None | 0.80A | 2byoA-2f8tA:undetectable | 2byoA-2f8tA:14.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i76 | HYPOTHETICAL PROTEIN (Thermotogamaritima) |
PF10728(DUF2520) | 4 | LEU A 16ILE A 28LEU A 29SER A 30 | NoneNoneNoneNDP A 301 (-2.7A) | 1.00A | 2byoA-2i76A:undetectable | 2byoA-2i76A:22.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ijx | DNA POLYMERASESLIDING CLAMP A (Sulfolobussolfataricus) |
PF00705(PCNA_N)PF02747(PCNA_C) | 4 | LEU A 18ILE A 47LEU A 46SER A 45 | None | 0.78A | 2byoA-2ijxA:undetectable | 2byoA-2ijxA:25.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jjf | L-LYSINE EPSILONAMINOTRANSFERASE (Mycobacteriumtuberculosis) |
PF00202(Aminotran_3) | 4 | LEU A 47ILE A 412LEU A 414ARG A 422 | None | 0.98A | 2byoA-2jjfA:undetectable | 2byoA-2jjfA:18.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jlm | PUTATIVEPHOSPHINOTHRICINN-ACETYLTRANSFERASE (Acinetobacterbaylyi) |
PF13420(Acetyltransf_4) | 4 | LEU A 73ILE A 27LEU A 28ARG A 44 | NoneNoneACT A1183 ( 4.5A)ACT A1183 ( 3.8A) | 0.93A | 2byoA-2jlmA:undetectable | 2byoA-2jlmA:23.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p18 | GLYOXALASE II (Leishmaniainfantum) |
PF00753(Lactamase_B)PF16123(HAGH_C) | 4 | LEU A 88ILE A 72LEU A 73SER A 74 | None | 0.77A | 2byoA-2p18A:undetectable | 2byoA-2p18A:21.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pgg | RNA-DIRECTED RNAPOLYMERASE (Infectiousbursal diseasevirus) |
PF04197(Birna_RdRp) | 4 | LEU A 254ILE A 252LEU A 346SER A 342 | None | 1.00A | 2byoA-2pggA:undetectable | 2byoA-2pggA:13.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vsx | EUKARYOTICINITIATION FACTOR 4FSUBUNIT P150 (Saccharomycescerevisiae) |
PF02854(MIF4G) | 4 | LEU E 617ILE E 629LEU E 630SER E 627 | None | 0.99A | 2byoA-2vsxE:undetectable | 2byoA-2vsxE:20.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vug | PAB1020 (Pyrococcusabyssi) |
PF09414(RNA_ligase) | 5 | LEU A 77ILE A 218LEU A 221SER A 222ARG A 226 | None | 1.44A | 2byoA-2vugA:undetectable | 2byoA-2vugA:18.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w1k | PUTATIVE SORTASE (Streptococcuspneumoniae) |
PF04203(Sortase) | 4 | LEU A 98ILE A 141SER A 139ARG A 138 | None | 0.89A | 2byoA-2w1kA:undetectable | 2byoA-2w1kA:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3af5 | PUTATIVEUNCHARACTERIZEDPROTEIN PH1404 (Pyrococcushorikoshii) |
PF07521(RMMBL)PF10996(Beta-Casp)PF16661(Lactamase_B_6)PF17214(KH_7) | 4 | LEU A 412ILE A 546LEU A 427SER A 544 | None | 0.86A | 2byoA-3af5A:undetectable | 2byoA-3af5A:15.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ajf | NON-STRUCTURALPROTEIN 3 (Rice hojablancatenuivirus) |
PF05310(Tenui_NS3) | 4 | LEU A 23ILE A 37LEU A 40SER A 41 | None | 0.91A | 2byoA-3ajfA:undetectable | 2byoA-3ajfA:17.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ci0 | PSEUDOPILIN GSPK (Escherichiacoli) |
PF03934(T2SSK) | 4 | LEU K 55ILE K 297LEU K 296SER K 295 | None | 0.82A | 2byoA-3ci0K:2.6 | 2byoA-3ci0K:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e8x | PUTATIVENAD-DEPENDENTEPIMERASE/DEHYDRATASE (Bacillushalodurans) |
PF13460(NAD_binding_10) | 4 | LEU A 200ILE A 174LEU A 152SER A 153 | NoneNoneNAP A 500 (-3.8A)None | 0.97A | 2byoA-3e8xA:undetectable | 2byoA-3e8xA:26.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ef1 | RNA POLYMERASE IISUBUNIT A C-TERMINALDOMAIN PHOSPHATASE (Schizosaccharomycespombe) |
PF03031(NIF)PF12738(PTCB-BRCT) | 4 | LEU A 282ILE A 168LEU A 167SER A 166 | None | 0.93A | 2byoA-3ef1A:undetectable | 2byoA-3ef1A:20.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3es5 | PUTATIVE CAPSIDPROTEIN (Penicilliumstoloniferumvirus F) |
no annotation | 4 | LEU A 301ILE A 217LEU A 214SER A 213 | None | 0.82A | 2byoA-3es5A:undetectable | 2byoA-3es5A:20.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h0n | UNCHARACTERIZEDPROTEIN DUF1470 (Jannaschia sp.CCS1) |
PF07336(ABATE)PF11706(zf-CGNR) | 4 | LEU A 15ILE A 73LEU A 76SER A 77 | None | 0.93A | 2byoA-3h0nA:undetectable | 2byoA-3h0nA:22.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h75 | PERIPLASMICSUGAR-BINDING DOMAINPROTEIN (Pseudomonasprotegens) |
PF13407(Peripla_BP_4) | 4 | LEU A 57ILE A 126LEU A 129SER A 130 | None | 0.85A | 2byoA-3h75A:undetectable | 2byoA-3h75A:21.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h90 | FERROUS-IRON EFFLUXPUMP FIEF (Escherichiacoli) |
PF01545(Cation_efflux)PF16916(ZT_dimer) | 4 | LEU A 47ILE A 50LEU A 54SER A 53 | None | 0.98A | 2byoA-3h90A:undetectable | 2byoA-3h90A:20.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j1w | PROTEIN PRGH (Salmonellaenterica) |
PF09480(PrgH) | 4 | ILE A 82LEU A 84SER A 96ARG A 95 | None | 0.91A | 2byoA-3j1wA:undetectable | 2byoA-3j1wA:20.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k9y | 1,25-DIHYDROXYVITAMIN D(3)24-HYDROXYLASE,MITOCHONDRIAL (Rattusnorvegicus) |
PF00067(p450) | 4 | LEU A 86ILE A 73LEU A 70SER A 69 | NoneNoneCM5 A 517 ( 4.6A)None | 0.87A | 2byoA-3k9yA:undetectable | 2byoA-3k9yA:18.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kts | GLYCEROL UPTAKEOPERONANTITERMINATORREGULATORY PROTEIN (Listeriamonocytogenes) |
PF04309(G3P_antiterm) | 4 | LEU A 75ILE A 84SER A 86ARG A 105 | NoneNoneNoneUNL A 191 ( 4.3A) | 0.93A | 2byoA-3ktsA:undetectable | 2byoA-3ktsA:24.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m8y | PHOSPHOPENTOMUTASE (Bacillus cereus) |
PF01676(Metalloenzyme) | 4 | LEU A 136ILE A 150LEU A 149SER A 148 | None | 1.00A | 2byoA-3m8yA:undetectable | 2byoA-3m8yA:19.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mca | ELONGATION FACTOR 1ALPHA-LIKE PROTEIN (Schizosaccharomycespombe) |
PF00009(GTP_EFTU)PF03143(GTP_EFTU_D3) | 4 | LEU A 571ILE A 484LEU A 485SER A 486 | None | 0.93A | 2byoA-3mcaA:undetectable | 2byoA-3mcaA:16.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oqn | CATABOLITE CONTROLPROTEIN A (Bacillussubtilis) |
PF00356(LacI)PF13377(Peripla_BP_3) | 4 | LEU A 234ILE A 244LEU A 245SER A 246 | None | 0.97A | 2byoA-3oqnA:undetectable | 2byoA-3oqnA:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3psq | HYPOTHETICALEXPORTED PROTEIN (Streptococcuspyogenes) |
PF04203(Sortase) | 4 | LEU A 71ILE A 123LEU A 122SER A 121 | None | 0.82A | 2byoA-3psqA:undetectable | 2byoA-3psqA:26.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q5e | ATLASTIN-1 (Homo sapiens) |
PF02263(GBP) | 4 | LEU A 304ILE A 213LEU A 212SER A 211 | None | 0.96A | 2byoA-3q5eA:undetectable | 2byoA-3q5eA:18.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qpt | TRANSCRIPTIONALREGULATOR SLYA (Salmonellaenterica) |
PF01047(MarR) | 4 | LEU A 12ILE A 15LEU A 19ARG A 23 | None | 0.92A | 2byoA-3qptA:undetectable | 2byoA-3qptA:24.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rht | (GATASE1)-LIKEPROTEIN (Planctopiruslimnophila) |
PF07090(GATase1_like) | 4 | LEU A 248ILE A 52LEU A 53SER A 54 | NoneNoneNone CA A 257 ( 4.0A) | 0.90A | 2byoA-3rhtA:undetectable | 2byoA-3rhtA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sdo | NITRILOTRIACETATEMONOOXYGENASE (Burkholderiapseudomallei) |
PF00296(Bac_luciferase) | 4 | LEU A 300ILE A 336LEU A 339ARG A 343 | None | 0.91A | 2byoA-3sdoA:undetectable | 2byoA-3sdoA:20.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3umm | PHOSPHORIBOSYLFORMYLGLYCINAMIDINESYNTHASE (Salmonellaenterica) |
PF02769(AIRS_C)PF13507(GATase_5) | 4 | LEU A 508ILE A 530LEU A 531SER A 532 | None | 0.83A | 2byoA-3ummA:undetectable | 2byoA-3ummA:10.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wq4 | BETA-PRIMEVEROSIDASE (Camelliasinensis) |
PF00232(Glyco_hydro_1) | 4 | LEU A 102ILE A 149LEU A 145SER A 146 | None | 0.93A | 2byoA-3wq4A:undetectable | 2byoA-3wq4A:20.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zoq | URACIL-DNAGLYCOSYLASE (Bacillussubtilis) |
PF03167(UDG) | 4 | ILE A 149LEU A 152SER A 153ARG A 155 | None | 0.76A | 2byoA-3zoqA:undetectable | 2byoA-3zoqA:24.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ab5 | TRANSCRIPTIONALREGULATOR, LYSRFAMILY (Neisseriameningitidis) |
PF03466(LysR_substrate) | 4 | LEU A 179ILE A 240LEU A 195ARG A 221 | None | 0.72A | 2byoA-4ab5A:undetectable | 2byoA-4ab5A:23.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4au2 | SERPIN PEPTIDASEINHIBITOR, CLADE H(HEAT SHOCK PROTEIN47), MEMBER 1,(COLLAGEN BINDINGPROTEIN 1) (Canis lupus) |
PF00079(Serpin) | 4 | LEU A 290ILE A 268LEU A 267SER A 266 | None | 0.84A | 2byoA-4au2A:1.1 | 2byoA-4au2A:22.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b8w | GDP-L-FUCOSESYNTHASE (Homo sapiens) |
PF01370(Epimerase) | 4 | ILE A 241LEU A 289SER A 287ARG A 290 | None | 0.97A | 2byoA-4b8wA:undetectable | 2byoA-4b8wA:20.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bnd | ALPHA-PHOSPHOGLUCOMUTASE (Lactococcuslactis) |
PF03332(PMM) | 4 | LEU B 200ILE B 4LEU B 5SER B 6 | None | 0.83A | 2byoA-4bndB:undetectable | 2byoA-4bndB:22.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bsj | VASCULAR ENDOTHELIALGROWTH FACTORRECEPTOR 3 (Homo sapiens) |
no annotation | 4 | LEU A 443ILE A 523SER A 439ARG A 437 | None | 1.00A | 2byoA-4bsjA:undetectable | 2byoA-4bsjA:20.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c3h | DNA-DIRECTED RNAPOLYMERASE I SUBUNITRPA190 (Saccharomycescerevisiae) |
PF00623(RNA_pol_Rpb1_2)PF04983(RNA_pol_Rpb1_3)PF04997(RNA_pol_Rpb1_1)PF04998(RNA_pol_Rpb1_5)PF05000(RNA_pol_Rpb1_4) | 4 | LEU A1313ILE A1498LEU A1262SER A1496 | None | 1.00A | 2byoA-4c3hA:undetectable | 2byoA-4c3hA:8.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4co6 | NUCLEOPROTEIN (Nipahhenipavirus) |
PF00973(Paramyxo_ncap) | 4 | LEU A 76ILE A 172LEU A 175ARG A 218 | None | 0.93A | 2byoA-4co6A:undetectable | 2byoA-4co6A:22.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d3d | IMINE REDUCTASE (Bacillus cereus) |
PF03446(NAD_binding_2) | 4 | LEU A 168ILE A 83LEU A 84SER A 85 | None | 0.79A | 2byoA-4d3dA:undetectable | 2byoA-4d3dA:21.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d7w | SORTASE FAMILYPROTEIN (Streptococcusagalactiae) |
PF04203(Sortase) | 4 | LEU A 197ILE A 145LEU A 146SER A 147 | None | 0.94A | 2byoA-4d7wA:undetectable | 2byoA-4d7wA:20.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ehi | BIFUNCTIONAL PURINEBIOSYNTHESIS PROTEINPURH (Campylobacterjejuni) |
PF01808(AICARFT_IMPCHas)PF02142(MGS) | 4 | LEU A 20ILE A 27LEU A 28SER A 29 | None | 0.64A | 2byoA-4ehiA:undetectable | 2byoA-4ehiA:17.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f4h | GLUTAMINE DEPENDENTNAD+ SYNTHETASE (Burkholderiathailandensis) |
PF00795(CN_hydrolase)PF02540(NAD_synthase) | 4 | LEU A 71ILE A 118LEU A 117SER A 116 | None | 0.83A | 2byoA-4f4hA:1.1 | 2byoA-4f4hA:17.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h17 | HYDROLASE,ISOCHORISMATASEFAMILY (Pseudomonasputida) |
PF00857(Isochorismatase) | 4 | LEU A 113ILE A 66LEU A 25SER A 24 | None | 0.72A | 2byoA-4h17A:undetectable | 2byoA-4h17A:25.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h3s | GLUTAMINE-TRNALIGASE (Saccharomycescerevisiae) |
PF00749(tRNA-synt_1c)PF03950(tRNA-synt_1c_C)PF04557(tRNA_synt_1c_R2) | 4 | LEU A 504ILE A 501LEU A 496SER A 497 | NoneACT A 914 ( 4.1A)NoneNone | 0.99A | 2byoA-4h3sA:undetectable | 2byoA-4h3sA:13.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i4q | BEL-BETA TREFOIL (Boletus edulis) |
no annotation | 4 | LEU A 118ILE A 24SER A 26ARG A 27 | NoneNoneNoneGOL A 201 (-4.0A) | 0.91A | 2byoA-4i4qA:undetectable | 2byoA-4i4qA:23.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i4s | BEL BETA-TREFOIL (Boletus edulis) |
no annotation | 4 | LEU A 118ILE A 24SER A 26ARG A 27 | NoneNoneNoneGOL A 203 (-3.9A) | 0.95A | 2byoA-4i4sA:undetectable | 2byoA-4i4sA:22.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lyl | URACIL-DNAGLYCOSYLASE (Gadus morhua) |
PF03167(UDG) | 4 | ILE A 230LEU A 233SER A 234ARG A 237 | None | 0.75A | 2byoA-4lylA:undetectable | 2byoA-4lylA:22.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lyl | URACIL-DNAGLYCOSYLASE (Gadus morhua) |
PF03167(UDG) | 4 | LEU A 244LEU A 233SER A 234ARG A 237 | None | 0.99A | 2byoA-4lylA:undetectable | 2byoA-4lylA:22.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mu6 | KINECTIN 1 (KINESINRECEPTOR) (Legionellapneumophila) |
no annotation | 4 | LEU A 267ILE A 36LEU A 37SER A 38 | None | 0.99A | 2byoA-4mu6A:undetectable | 2byoA-4mu6A:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mz0 | CURL (Mooreaproducens) |
PF00109(ketoacyl-synt)PF00698(Acyl_transf_1)PF02801(Ketoacyl-synt_C)PF16197(KAsynt_C_assoc) | 4 | LEU A 848ILE A 813LEU A 812SER A 811 | None | 0.92A | 2byoA-4mz0A:undetectable | 2byoA-4mz0A:13.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nhy | 2-OXOGLUTARATE ANDIRON-DEPENDENTOXYGENASEDOMAIN-CONTAININGPROTEIN 1 (Homo sapiens) |
PF10637(Ofd1_CTDD)PF13661(2OG-FeII_Oxy_4) | 4 | LEU A 104ILE A 233LEU A 170SER A 232 | NoneNoneNonePD2 A 603 (-3.1A) | 0.99A | 2byoA-4nhyA:undetectable | 2byoA-4nhyA:17.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4onz | PUTATIVE GLYCOSIDEHYDROLASE (Bacteroidesovatus) |
PF04041(Glyco_hydro_130) | 4 | LEU A 239ILE A 204LEU A 205ARG A 276 | None | 0.98A | 2byoA-4onzA:1.2 | 2byoA-4onzA:21.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r0m | MCYG PROTEIN (Microcystisaeruginosa) |
no annotation | 4 | LEU B 116ILE B 128LEU B 129SER B 130 | None | 0.97A | 2byoA-4r0mB:undetectable | 2byoA-4r0mB:15.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r8f | VACUOLARAMINOPEPTIDASE 1 (Saccharomycescerevisiae) |
PF02127(Peptidase_M18) | 4 | LEU A 310ILE A 337LEU A 338SER A 339 | None | 0.98A | 2byoA-4r8fA:undetectable | 2byoA-4r8fA:19.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rcw | SLIT AND NTRK-LIKEPROTEIN 1 (Homo sapiens) |
PF13855(LRR_8) | 4 | LEU A 552ILE A 524LEU A 501SER A 500 | None | 0.98A | 2byoA-4rcwA:undetectable | 2byoA-4rcwA:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rhb | LPS-ASSEMBLY PROTEINLPTD (Escherichiacoli) |
PF04453(OstA_C) | 4 | LEU A 540ILE A 582LEU A 606SER A 605 | None | 1.00A | 2byoA-4rhbA:2.6 | 2byoA-4rhbA:17.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u14 | MUSCARINICACETYLCHOLINERECEPTORM3,ENDOLYSIN,MUSCARINIC ACETYLCHOLINERECEPTOR M3 (Escherichiavirus T4;Rattusnorvegicus) |
PF00001(7tm_1)PF00959(Phage_lysozyme) | 4 | LEU A 106ILE A 495LEU A 496SER A 493 | None | 0.94A | 2byoA-4u14A:undetectable | 2byoA-4u14A:16.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u3t | PENICILLIN-BINDINGPROTEIN 2 (Neisseriagonorrhoeae) |
PF00905(Transpeptidase) | 4 | LEU A 473ILE A 317LEU A 370ARG A 373 | None | 0.98A | 2byoA-4u3tA:undetectable | 2byoA-4u3tA:24.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w7g | DYNEIN LIGHTINTERMEDIATE CHAIN (Chaetomiumthermophilum) |
PF05783(DLIC) | 4 | LEU A 279ILE A 269LEU A 268SER A 267 | None | 0.84A | 2byoA-4w7gA:undetectable | 2byoA-4w7gA:18.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xpz | RNA POLYMERASE IISUBUNIT A C-TERMINALDOMAIN PHOSPHATASE (Schizosaccharomycespombe) |
PF03031(NIF)PF12738(PTCB-BRCT) | 4 | LEU A 282ILE A 168LEU A 167SER A 166 | None | 0.91A | 2byoA-4xpzA:undetectable | 2byoA-4xpzA:22.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yf6 | BETA-CARBONICANHYDRASE 1 (Mycobacteriumtuberculosis) |
PF00484(Pro_CA) | 4 | LEU A 71ILE A 134LEU A 131SER A 130 | None | 0.82A | 2byoA-4yf6A:undetectable | 2byoA-4yf6A:22.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zqi | D-ALANINE--D-ALANINELIGASE (Yersinia pestis) |
PF01820(Dala_Dala_lig_N)PF07478(Dala_Dala_lig_C) | 4 | LEU A 242ILE A 192LEU A 193ARG A 300 | None | 0.99A | 2byoA-4zqiA:undetectable | 2byoA-4zqiA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c3u | L-SERINEAMMONIA-LYASE (Rhizomucormiehei) |
PF00291(PALP) | 4 | ILE A 98LEU A 119SER A 117ARG A 113 | None | 0.99A | 2byoA-5c3uA:undetectable | 2byoA-5c3uA:22.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cvi | SLOR (Streptococcusmutans) |
PF01325(Fe_dep_repress)PF02742(Fe_dep_repr_C)PF04023(FeoA) | 4 | ILE A 12LEU A 15SER A 16ARG A 18 | None | 0.86A | 2byoA-5cviA:undetectable | 2byoA-5cviA:20.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fd5 | FERRIC UPTAKEREGULATION PROTEIN (Rhizobiumleguminosarum) |
PF01475(FUR) | 4 | LEU A 130ILE A 110LEU A 113ARG A 116 | None | 0.88A | 2byoA-5fd5A:undetectable | 2byoA-5fd5A:21.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5flz | SPINDLE POLE BODYCOMPONENT SPC97 (Saccharomycescerevisiae) |
PF04130(Spc97_Spc98) | 4 | ILE A 363LEU A 361SER A 360ARG A 358 | None | 0.82A | 2byoA-5flzA:undetectable | 2byoA-5flzA:13.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gn5 | GLYCEROL KINASE (Trypanosomabrucei) |
PF00370(FGGY_N)PF02782(FGGY_C) | 5 | LEU A 429ILE A 432LEU A 436SER A 435ARG A 493 | None | 1.48A | 2byoA-5gn5A:undetectable | 2byoA-5gn5A:18.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h7w | VENOM5'-NUCLEOTIDASE (Naja atra) |
no annotation | 4 | LEU A 131ILE A 139LEU A 140SER A 141 | None | 0.97A | 2byoA-5h7wA:undetectable | 2byoA-5h7wA:17.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hdh | TOLL-LIKE RECEPTOR 8 (Homo sapiens) |
PF13855(LRR_8) | 4 | LEU A 474ILE A 422LEU A 420SER A 397 | None | 0.88A | 2byoA-5hdhA:undetectable | 2byoA-5hdhA:14.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j3p | TYROSYL-DNAPHOSPHODIESTERASE 2 (Homo sapiens) |
PF03372(Exo_endo_phos) | 4 | LEU A 140ILE A 117LEU A 116SER A 115 | None | 0.93A | 2byoA-5j3pA:undetectable | 2byoA-5j3pA:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j4a | IMMUNITY PROTEINCDII (Burkholderiapseudomallei) |
no annotation | 4 | ILE B 66LEU B 64SER B 62ARG B 103 | None | 0.98A | 2byoA-5j4aB:undetectable | 2byoA-5j4aB:20.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jpe | SERINE/THREONINE-PROTEIN PHOSPHATASE (Candidaalbicans) |
PF00149(Metallophos)PF16891(STPPase_N) | 5 | LEU A 366ILE A 326LEU A 217SER A 216ARG A 352 | None | 1.35A | 2byoA-5jpeA:undetectable | 2byoA-5jpeA:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5koh | NITROGENASE FEMOBETA SUBUNIT PROTEINNIFK (Gluconacetobacterdiazotrophicus) |
PF00148(Oxidored_nitro)PF11844(DUF3364) | 4 | LEU B 236ILE B 249LEU B 250SER B 251 | None | 0.83A | 2byoA-5kohB:undetectable | 2byoA-5kohB:19.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n4a | INTRAFLAGELLARTRANSPORT PROTEIN 80 (Chlamydomonasreinhardtii) |
no annotation | 4 | LEU A 173ILE A 130LEU A 119SER A 132 | None | 0.95A | 2byoA-5n4aA:undetectable | 2byoA-5n4aA:19.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5udb | DNA REPLICATIONLICENSING FACTORMCM2 (Saccharomycescerevisiae) |
PF00493(MCM)PF14551(MCM_N)PF17207(MCM_OB) | 4 | LEU 2 268LEU 2 242SER 2 241ARG 2 230 | None | 0.78A | 2byoA-5udb2:undetectable | 2byoA-5udb2:12.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uj8 | ORIGIN RECOGNITIONCOMPLEX SUBUNIT 3 (Homo sapiens) |
PF07034(ORC3_N) | 4 | ILE A 152LEU A 200SER A 201ARG A 204 | None | 0.91A | 2byoA-5uj8A:undetectable | 2byoA-5uj8A:13.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v0r | UBIQUITIN-CONJUGATING ENZYME (Naegleriafowleri) |
PF00179(UQ_con) | 4 | LEU A 68ILE A 120LEU A 121SER A 119 | None | 0.98A | 2byoA-5v0rA:undetectable | 2byoA-5v0rA:19.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vl1 | LYSINE--TRNA LIGASE (Mycobacteriumulcerans) |
PF00152(tRNA-synt_2)PF01336(tRNA_anti-codon) | 4 | ILE A 92LEU A 102SER A 101ARG A 99 | None | 0.95A | 2byoA-5vl1A:1.4 | 2byoA-5vl1A:19.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wxi | EARP (Neisseriameningitidis) |
no annotation | 4 | LEU A 27ILE A 152LEU A 151SER A 366 | None | 0.87A | 2byoA-5wxiA:undetectable | 2byoA-5wxiA:18.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y1a | - (-) |
no annotation | 4 | LEU A 73ILE A 190LEU A 191SER A 192 | None | 0.93A | 2byoA-5y1aA:0.6 | 2byoA-5y1aA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6axg | RAS GUANYL-RELEASINGPROTEIN 4 (Homo sapiens) |
no annotation | 4 | ILE A 422LEU A 425SER A 426ARG A 429 | None | 0.93A | 2byoA-6axgA:undetectable | 2byoA-6axgA:19.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6dm8 | - (-) |
no annotation | 4 | LEU A 248ILE A 163LEU A 160SER A 159 | 6AK A 401 (-4.3A)NoneNoneNone | 0.88A | 2byoA-6dm8A:undetectable | 2byoA-6dm8A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6en4 | SPLICING FACTOR 3BSUBUNIT 3 (Homo sapiens) |
no annotation | 4 | LEU A 679ILE A 616LEU A 605SER A 618 | None | 0.96A | 2byoA-6en4A:undetectable | 2byoA-6en4A:19.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f42 | DNA-DIRECTED RNAPOLYMERASE IIISUBUNIT RPC8 (Saccharomycescerevisiae) |
no annotation | 4 | ILE G 3LEU G 4SER G 5ARG G 73 | None | 0.84A | 2byoA-6f42G:undetectable | 2byoA-6f42G:16.67 |