SIMILAR PATTERNS OF AMINO ACIDS FOR 2BXQ_A_P1ZA2002_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cbk PROTEIN
(7,8-DIHYDRO-6-HYDRO
XYMETHYLPTERIN-PYROP
HOSPHOKINASE)

(Haemophilus
influenzae) 		PF01288
(HPPK) 		6 LEU A  94
LEU A  19
LEU A  23
ILE A  26
ILE A   6
ALA A   7
 None
 1.05A 2bxqA-1cbkA:
undetectable		 2bxqA-1cbkA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6v METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT

(Methanopyrus
kandleri) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		5 LEU B 113
LEU B  51
ILE B  54
ILE B 143
ALA B 142
 None
 0.99A 2bxqA-1e6vB:
1.0		 2bxqA-1e6vB:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		5 LEU A 307
LEU A 285
ILE A 280
ILE A 348
ALA A 349
 None
 0.97A 2bxqA-1g8xA:
1.7		 2bxqA-1g8xA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmy BILE-SALT-ACTIVATED
LIPASE

(Homo sapiens) 		PF00135
(COesterase) 		5 LEU A   3
LEU A  98
ILE A 137
ILE A 178
ALA A 179
 None
 0.85A 2bxqA-1jmyA:
0.4		 2bxqA-1jmyA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jug LYSOZYME

(Tachyglossus
aculeatus) 		PF00062
(Lys) 		5 LEU A  12
LEU A  92
ILE A  88
ILE A  55
ALA A  32
 None
 0.94A 2bxqA-1jugA:
undetectable		 2bxqA-1jugA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jx2 MYOSIN-2 HEAVY
CHAIN,DYNAMIN-A

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		5 LEU A 318
LEU A 296
ILE A 291
ILE A 359
ALA A 360
 None
 0.98A 2bxqA-1jx2A:
3.2		 2bxqA-1jx2A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5j PERIPLASMIC DIVALENT
CATION TOLERANCE
PROTEIN

(Thermotoga
maritima) 		PF03091
(CutA1) 		5 LEU A  69
HIS A  73
LEU A  21
ILE A  27
ALA A  53
 None
 1.02A 2bxqA-1o5jA:
undetectable		 2bxqA-1o5jA:
11.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		6 LEU A 219
ARG A 222
PHE A 223
LEU A 238
HIS A 242
ILE A 264
 None
CIT  A2001 ( 2.9A)
None
DKA  A1003 (-4.3A)
DKA  A1003 (-3.7A)
None
 1.45A 2bxqA-1tf0A:
38.1		 2bxqA-1tf0A:
99.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		10 LYS A 199
LEU A 219
ARG A 222
PHE A 223
LEU A 238
HIS A 242
ILE A 264
SER A 287
ILE A 290
ALA A 291
 CIT  A2001 ( 2.7A)
None
CIT  A2001 ( 2.9A)
None
DKA  A1003 (-4.3A)
DKA  A1003 (-3.7A)
None
None
DKA  A1003 ( 4.5A)
CIT  A2001 ( 3.9A)
 0.82A 2bxqA-1tf0A:
38.1		 2bxqA-1tf0A:
99.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		11 LYS A 199
LEU A 219
PHE A 223
LEU A 238
HIS A 242
ARG A 257
LEU A 260
ILE A 264
SER A 287
ILE A 290
ALA A 291
 CIT  A2001 ( 2.7A)
None
None
DKA  A1003 (-4.3A)
DKA  A1003 (-3.7A)
DKA  A1003 (-4.1A)
None
None
None
DKA  A1003 ( 4.5A)
CIT  A2001 ( 3.9A)
 0.83A 2bxqA-1tf0A:
38.1		 2bxqA-1tf0A:
99.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uli BIPHENYL DIOXYGENASE
SMALL SUBUNIT

(Rhodococcus
jostii) 		PF00866
(Ring_hydroxyl_B) 		5 PHE B  46
LEU B  37
HIS B 111
ILE B  95
SER B 184
 None
 0.98A 2bxqA-1uliB:
undetectable		 2bxqA-1uliB:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhf PERIPLASMIC DIVALENT
CATION TOLERANCE
PROTEIN

(Thermotoga
maritima) 		PF03091
(CutA1) 		5 LEU A  69
HIS A  73
LEU A  21
ILE A  27
ALA A  53
 None
 0.99A 2bxqA-1vhfA:
undetectable		 2bxqA-1vhfA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vl4 PMBA-RELATED PROTEIN

(Thermotoga
maritima) 		PF01523
(PmbA_TldD) 		5 LEU A 235
LEU A 403
LEU A 430
ILE A 396
ILE A 356
 None
 0.90A 2bxqA-1vl4A:
undetectable		 2bxqA-1vl4A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w36 EXODEOXYRIBONUCLEASE
V GAMMA CHAIN

(Escherichia
coli) 		PF04257
(Exonuc_V_gamma) 		5 LEU C 224
LEU C 314
ILE C 213
ILE C 216
ALA C 218
 None
 1.02A 2bxqA-1w36C:
0.0		 2bxqA-1w36C:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w55 ISPD/ISPF
BIFUNCTIONAL ENZYME

(Campylobacter
jejuni) 		PF01128
(IspD)
PF02542
(YgbB) 		5 LEU A 286
LEU A 300
ILE A 303
ILE A 336
ALA A 326
 None
 0.90A 2bxqA-1w55A:
undetectable		 2bxqA-1w55A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9j BISPHOSPHOGLYCERATE
MUTASE

(Homo sapiens) 		PF00300
(His_Phos_1) 		5 LEU A 199
LEU A 195
ILE A 185
ILE A 173
ALA A 174
 None
 0.99A 2bxqA-2a9jA:
undetectable		 2bxqA-2a9jA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dg0 DRP35

(Staphylococcus
aureus) 		PF08450
(SGL) 		5 ARG A  80
LEU A  47
LEU A 309
ILE A  71
ILE A  78
 None
 1.00A 2bxqA-2dg0A:
undetectable		 2bxqA-2dg0A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dh3 4F2 CELL-SURFACE
ANTIGEN HEAVY CHAIN

(Homo sapiens) 		PF00128
(Alpha-amylase) 		5 LEU A 192
PHE A 189
LEU A 143
LEU A 129
ILE A 163
 None
 0.87A 2bxqA-2dh3A:
undetectable		 2bxqA-2dh3A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fno AGR_PAT_752P

(Agrobacterium
fabrum) 		no annotation 6 LEU A 172
LEU A 112
LEU A 133
ILE A 137
ILE A 187
ALA A 177
 None
None
None
None
SCN  A 237 ( 3.9A)
SCN  A 237 (-3.4A)
 1.34A 2bxqA-2fnoA:
undetectable		 2bxqA-2fnoA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g29 NITRATE TRANSPORT
PROTEIN NRTA

(Synechocystis
sp.) 		PF13379
(NMT1_2) 		5 LEU A 175
LEU A 204
ILE A 200
ILE A 157
ALA A 256
 None
 1.02A 2bxqA-2g29A:
undetectable		 2bxqA-2g29A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g5x RIBOSOME-INACTIVATIN
G PROTEIN

(Silene
chalcedonica) 		PF00161
(RIP) 		5 LEU A 135
PHE A 190
ILE A 196
ILE A 177
ALA A 171
 None
 1.03A 2bxqA-2g5xA:
undetectable		 2bxqA-2g5xA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5p GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
1

(Kluyveromyces
marxianus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 LEU O  16
ILE O  25
SER O   2
ILE O   3
ALA O   4
 None
 1.02A 2bxqA-2i5pO:
undetectable		 2bxqA-2i5pO:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j04 YDR362CP

(Saccharomyces
cerevisiae) 		no annotation 6 LEU B 276
ARG B 281
PHE B 273
LEU B 256
ILE B 285
ILE B 616
 None
 1.48A 2bxqA-2j04B:
undetectable		 2bxqA-2j04B:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oze ORF DELTA'

(Streptococcus
pyogenes) 		PF13614
(AAA_31) 		5 LEU A 125
LEU A 100
LEU A 105
ILE A 119
ILE A  71
 None
 0.99A 2bxqA-2ozeA:
undetectable		 2bxqA-2ozeA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qh5 MANNOSE-6-PHOSPHATE
ISOMERASE

(Helicobacter
pylori) 		PF00483
(NTP_transferase) 		5 PHE A 191
HIS A 112
LEU A   8
ILE A  92
ILE A 244
 None
 0.99A 2bxqA-2qh5A:
undetectable		 2bxqA-2qh5A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfo NUCLEOPORIN NIC96

(Saccharomyces
cerevisiae) 		PF04097
(Nic96) 		5 LEU A 513
LEU A 260
ILE A 234
ILE A 508
ALA A 507
 None
 1.02A 2bxqA-2rfoA:
undetectable		 2bxqA-2rfoA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vha PERIPLASMIC BINDING
TRANSPORT PROTEIN

(Shigella
flexneri) 		PF00497
(SBP_bac_3) 		6 LEU A  10
PHE A 222
LEU A  58
LEU A  63
ILE A  19
ALA A  53
 None
 1.28A 2bxqA-2vhaA:
undetectable		 2bxqA-2vhaA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vtw FIBER PROTEIN 2

(Fowl
aviadenovirus A) 		PF16812
(AdHead_fibreRBD) 		6 LEU A 383
PHE A 277
LEU A 347
ILE A 352
ILE A 394
ALA A 393
 None
 1.25A 2bxqA-2vtwA:
undetectable		 2bxqA-2vtwA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w61 GLYCOLIPID-ANCHORED
SURFACE PROTEIN 2

(Saccharomyces
cerevisiae) 		PF03198
(Glyco_hydro_72)
PF07983
(X8) 		6 LEU A 133
LEU A 131
LEU A 168
ILE A 209
SER A 164
ALA A 161
 None
 1.45A 2bxqA-2w61A:
undetectable		 2bxqA-2w61A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xa7 AP-2 COMPLEX SUBUNIT
BETA

(Homo sapiens) 		PF01602
(Adaptin_N) 		5 LEU B 436
LEU B 465
ILE B 451
ILE B 429
ALA B 430
 None
 0.97A 2bxqA-2xa7B:
undetectable		 2bxqA-2xa7B:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywo PROBABLE
THIOL-DISULFIDE
ISOMERASE/THIOREDOXI
N

(Thermus
thermophilus) 		PF00578
(AhpC-TSA) 		5 LEU A 122
LEU A 157
ARG A 159
LEU A 158
ALA A 152
 None
 1.00A 2bxqA-2ywoA:
undetectable		 2bxqA-2ywoA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z63 TOLL-LIKE RECEPTOR
4, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A  83
LEU A  85
LEU A  66
ILE A  48
ALA A  97
 None
 1.01A 2bxqA-2z63A:
undetectable		 2bxqA-2z63A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		6 LEU B 400
LEU B 425
LEU B 428
ILE B 405
ILE B 390
ALA B 391
 None
 1.46A 2bxqA-2z7xB:
undetectable		 2bxqA-2z7xB:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zau SELENIDE, WATER
DIKINASE

(Aquifex
aeolicus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		6 LEU A 143
PHE A 141
LEU A 121
LEU A 118
ILE A 114
ALA A  74
 None
 1.33A 2bxqA-2zauA:
undetectable		 2bxqA-2zauA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqq BENZENE
1,2-DIOXYGENASE
SUBUNIT BETA

(Pseudomonas
putida) 		PF00866
(Ring_hydroxyl_B) 		5 PHE B  46
LEU B  37
HIS B 111
ILE B  95
SER B 184
 None
 1.00A 2bxqA-3eqqB:
undetectable		 2bxqA-3eqqB:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fjv UNCHARACTERIZED
NOVEL PROTEIN

(Burkholderia
pseudomallei) 		PF12007
(DUF3501) 		5 LEU A  86
LEU A 116
ILE A 166
ILE A 180
ALA A 185
 None
 0.91A 2bxqA-3fjvA:
2.7		 2bxqA-3fjvA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ivf TALIN-1

(Mus musculus) 		PF00373
(FERM_M)
PF02174
(IRS)
PF09379
(FERM_N)
PF16511
(FERM_f0) 		5 LEU A  68
PHE A  19
LEU A  62
ILE A  32
ILE A   8
 None
 1.02A 2bxqA-3ivfA:
2.3		 2bxqA-3ivfA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kez PUTATIVE SUGAR
BINDING PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 LEU A 117
LEU A  48
ILE A  51
ILE A 143
ALA A 142
 None
 0.97A 2bxqA-3kezA:
undetectable		 2bxqA-3kezA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl4 SIGNAL RECOGNITION
54 KDA PROTEIN

(Sulfolobus
solfataricus) 		PF00448
(SRP54)
PF02881
(SRP54_N)
PF02978
(SRP_SPB) 		5 PHE A  70
LEU A  78
LEU A  47
ILE A  51
ILE A  27
 None
 1.02A 2bxqA-3kl4A:
4.0		 2bxqA-3kl4A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzu 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE II

(Brucella
melitensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 LEU A 386
LEU A 322
ILE A 308
ILE A 336
ALA A 333
 None
 0.99A 2bxqA-3kzuA:
undetectable		 2bxqA-3kzuA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2k EHPF

(Pantoea
agglomerans) 		PF00501
(AMP-binding) 		5 LEU A 198
LEU A 216
LEU A 213
ILE A 233
ALA A 138
 None
 0.98A 2bxqA-3l2kA:
undetectable		 2bxqA-3l2kA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lnt 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Burkholderia
pseudomallei) 		PF00300
(His_Phos_1) 		5 LEU A 193
LEU A 189
ILE A 179
ILE A 167
ALA A 168
 None
 1.04A 2bxqA-3lntA:
undetectable		 2bxqA-3lntA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3niw HALOACID
DEHALOGENASE-LIKE
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF08282
(Hydrolase_3) 		5 LEU A  57
LEU A  14
ILE A   6
ILE A 263
ALA A 260
 None
 1.02A 2bxqA-3niwA:
undetectable		 2bxqA-3niwA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o82 PEPTIDE ARYLATION
ENZYME

(Acinetobacter
baumannii) 		PF00501
(AMP-binding) 		6 LEU A  85
LEU A 160
LEU A 170
ILE A 173
ILE A  93
ALA A  89
 None
 1.47A 2bxqA-3o82A:
undetectable		 2bxqA-3o82A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oja ANOPHELES
PLASMODIUM-RESPONSIV
E LEUCINE-RICH
REPEAT PROTEIN 1

(Anopheles
gambiae) 		PF13855
(LRR_8) 		5 LEU B 377
PHE B 401
LEU B 393
ILE B 396
ILE B 412
 None
 1.03A 2bxqA-3ojaB:
undetectable		 2bxqA-3ojaB:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8c NCK-ASSOCIATED
PROTEIN 1

(Homo sapiens) 		PF09735
(Nckap1) 		5 LEU B 999
LEU B1043
ILE B 910
SER B 860
ALA B 864
 None
 1.04A 2bxqA-3p8cB:
4.3		 2bxqA-3p8cB:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qtg PYRUVATE KINASE

(Pyrobaculum
aerophilum) 		PF00224
(PK)
PF02887
(PK_C) 		5 LEU A 218
LEU A 187
SER A 203
ILE A 202
ALA A 201
 None
 1.02A 2bxqA-3qtgA:
undetectable		 2bxqA-3qtgA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t66 NICKEL ABC
TRANSPORTER
(NICKEL-BINDING
PROTEIN)

(Bacillus
halodurans) 		PF00496
(SBP_bac_5) 		6 LEU A 137
PHE A 133
HIS A  29
LEU A 100
ILE A 112
ILE A 115
 None
 1.49A 2bxqA-3t66A:
undetectable		 2bxqA-3t66A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vml 3-ISOPROPYLMALATE
DEHYDROGENASE

(Shewanella
benthica;
Shewanella
oneidensis) 		PF00180
(Iso_dh) 		5 ARG A 107
ILE A 132
SER A 252
ILE A 255
ALA A 256
 IPM  A 401 (-4.5A)
None
None
None
None
 1.03A 2bxqA-3vmlA:
undetectable		 2bxqA-3vmlA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akk NITRATE REGULATORY
PROTEIN

(Klebsiella
oxytoca) 		PF03861
(ANTAR)
PF08376
(NIT) 		5 LEU A  86
PHE A  82
LEU A  97
ILE A 142
ALA A 102
 None
 0.92A 2bxqA-4akkA:
3.1		 2bxqA-4akkA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ay1 CHITINASE-3-LIKE
PROTEIN 2

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		6 LEU A 158
PHE A 111
LEU A 162
LEU A 140
ILE A 101
ALA A 182
 None
 1.44A 2bxqA-4ay1A:
undetectable		 2bxqA-4ay1A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bju N-ACETYLGLUCOSAMINE-
PHOSPHATE MUTASE

(Aspergillus
fumigatus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I) 		5 PHE A 389
HIS A 441
LEU A 434
ILE A 421
ALA A 416
 None
 0.99A 2bxqA-4bjuA:
undetectable		 2bxqA-4bjuA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cmh HEAVY CHAIN OF
SAR650984-FAB
FRAGMENT

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 LYS B  63
LEU B  86
LEU B  83
LEU B  20
ALA B  92
 None
 0.97A 2bxqA-4cmhB:
undetectable		 2bxqA-4cmhB:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4evf GIARDIN SUBUNIT
ALPHA-1

(Giardia
intestinalis) 		PF00191
(Annexin) 		5 PHE A  71
LEU A  66
ILE A  54
ILE A  23
ALA A  24
 None
 1.02A 2bxqA-4evfA:
undetectable		 2bxqA-4evfA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0b THIOL TRANSFERASE

(Phanerochaete
chrysosporium) 		PF00043
(GST_C)
PF02798
(GST_N) 		6 LEU A  29
LEU A  91
LEU A  88
ILE A 181
ILE A  24
ALA A  23
 None
 1.17A 2bxqA-4f0bA:
undetectable		 2bxqA-4f0bA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gtn ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Acinetobacter
sp. ADP1) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		5 LEU A 285
PHE A 111
LEU A 251
ILE A 316
ALA A 313
 None
 0.99A 2bxqA-4gtnA:
undetectable		 2bxqA-4gtnA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1g MALTOSE BINDING
PROTEIN-CAKAR3 MOTOR
DOMAIN FUSION
PROTEIN

(Candida
albicans;
Escherichia
coli) 		PF00225
(Kinesin)
PF13416
(SBP_bac_8) 		5 HIS A 557
LEU A 498
ILE A 488
ILE A 495
ALA A 494
 None
 0.99A 2bxqA-4h1gA:
undetectable		 2bxqA-4h1gA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4inj LMO1638 PROTEIN

(Listeria
monocytogenes) 		PF02016
(Peptidase_S66) 		5 LEU A 211
LEU A 208
ILE A 201
ILE A 305
ALA A 117
 None
 0.94A 2bxqA-4injA:
undetectable		 2bxqA-4injA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jg5 PUTATIVE CELL
ADHESION PROTEIN

(Parabacteroides
distasonis) 		PF06321
(P_gingi_FimA) 		5 LEU A 356
PHE A 328
LEU A 191
ILE A 194
ILE A 210
 None
 0.84A 2bxqA-4jg5A:
undetectable		 2bxqA-4jg5A:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lhs UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF14606
(Lipase_GDSL_3)
PF14607
(GxDLY) 		5 LEU A 157
PHE A  50
LEU A 109
LEU A 149
ILE A  77
 None
 1.03A 2bxqA-4lhsA:
undetectable		 2bxqA-4lhsA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mbg CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus) 		PF00432
(Prenyltrans) 		5 LEU B 491
LEU B 124
HIS B 129
LEU B 411
ALA B 437
 None
 0.89A 2bxqA-4mbgB:
undetectable		 2bxqA-4mbgB:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mwg PUTATIVE
DIHYDROMETHANOPTERIN
REDUCTASE (AFPA)

(Paraburkholderia
xenovorans) 		PF02441
(Flavoprotein) 		5 LEU A  39
PHE A  18
LEU A  35
LEU A 178
ILE A 129
 None
 1.00A 2bxqA-4mwgA:
undetectable		 2bxqA-4mwgA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oun MINI-RIBONUCLEASE 3

(Bacillus
subtilis) 		PF00636
(Ribonuclease_3) 		5 LEU A 129
PHE A  46
LEU A  85
ILE A  81
ALA A 146
 None
 0.99A 2bxqA-4ounA:
undetectable		 2bxqA-4ounA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfw ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF00496
(SBP_bac_5) 		6 LEU A 282
LEU A 401
ILE A 397
SER A 301
ILE A 302
ALA A 299
 None
 1.38A 2bxqA-4pfwA:
undetectable		 2bxqA-4pfwA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj6 LEUCYL-CYSTINYL
AMINOPEPTIDASE

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		5 LEU A1025
PHE A 750
LEU A 787
LEU A 779
ILE A 775
 None
 1.02A 2bxqA-4pj6A:
3.0		 2bxqA-4pj6A:
21.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		7 LEU A 219
ARG A 222
PHE A 223
LEU A 238
HIS A 242
LEU A 260
ILE A 290
 None
 0.76A 2bxqA-4po0A:
40.4		 2bxqA-4po0A:
74.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		5 LEU A 219
LEU A 238
HIS A 242
ARG A 257
LEU A 260
 None
 0.77A 2bxqA-4po0A:
40.4		 2bxqA-4po0A:
74.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tz0 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 LEU A 533
PHE A 352
ILE A 356
ILE A 451
ALA A 380
 None
 0.98A 2bxqA-4tz0A:
2.1		 2bxqA-4tz0A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus) 		PF00464
(SHMT) 		5 LEU A 331
LEU A 338
ILE A  24
ILE A 376
ALA A 377
 None
 1.00A 2bxqA-4wxbA:
undetectable		 2bxqA-4wxbA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z64 PHYTOSULFOKINE
RECEPTOR 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 LEU A 154
LEU A 129
LEU A 149
ILE A 167
ILE A 144
 None
None
None
None
NAG  A 702 (-4.8A)
 0.79A 2bxqA-4z64A:
undetectable		 2bxqA-4z64A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5avo HOMOSERINE
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		6 LEU A  27
LEU A  19
LEU A   3
ILE A  68
ILE A  98
ALA A 292
 None
 1.36A 2bxqA-5avoA:
undetectable		 2bxqA-5avoA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c7m E3 UBIQUITIN-PROTEIN
LIGASE ITCHY HOMOLOG

(Homo sapiens) 		PF00632
(HECT) 		6 LEU A 886
PHE A 815
LEU A 877
LEU A 875
ILE A 894
ALA A 893
 None
 1.45A 2bxqA-5c7mA:
undetectable		 2bxqA-5c7mA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c9e SEPL

(Escherichia
coli) 		PF07201
(HrpJ) 		6 LEU A 167
LEU A 154
LEU A 137
SER A 135
ILE A 100
ALA A 131
 None
 1.31A 2bxqA-5c9eA:
2.9		 2bxqA-5c9eA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cee NAD-DEPENDENT MALIC
ENZYME

(Aster yellows
witches'-broom
phytoplasma) 		PF00390
(malic)
PF03949
(Malic_M) 		6 LEU A 204
LEU A 234
LEU A 213
ILE A 189
ILE A 199
ALA A 198
 None
 1.33A 2bxqA-5ceeA:
undetectable		 2bxqA-5ceeA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cqb DITRANS,POLYCIS-UNDE
CAPRENYL-DIPHOSPHATE
SYNTHASE
((2E,6E)-FARNESYL-DI
PHOSPHATE SPECIFIC)

(Escherichia
coli) 		PF01255
(Prenyltransf) 		6 PHE A 224
LEU A 233
HIS A  16
LEU A 191
ILE A 193
ILE A  23
 None
 1.39A 2bxqA-5cqbA:
undetectable		 2bxqA-5cqbA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyk RIBOSOME BIOGENESIS
PROTEIN YTM1

(Chaetomium
thermophilum) 		PF00400
(WD40)
PF08154
(NLE) 		6 LEU A 147
PHE A 185
LEU A 155
HIS A 176
LEU A 215
ALA A 192
 None
 1.44A 2bxqA-5cykA:
undetectable		 2bxqA-5cykA:
21.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		10 LEU A 218
PHE A 222
LEU A 237
HIS A 241
ARG A 256
LEU A 259
ILE A 263
SER A 286
ILE A 289
ALA A 290
 None
None
PG4  A 602 (-4.7A)
PG4  A 602 (-4.0A)
PG4  A 602 (-4.1A)
PG4  A 602 ( 4.5A)
None
PG4  A 602 (-3.9A)
PG4  A 602 ( 4.4A)
PG4  A 602 (-3.4A)
 0.62A 2bxqA-5dqfA:
41.5		 2bxqA-5dqfA:
76.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		6 LYS A 198
HIS A 241
ILE A 263
SER A 286
ILE A 289
ALA A 290
 PG4  A 602 ( 4.3A)
PG4  A 602 (-4.0A)
None
PG4  A 602 (-3.9A)
PG4  A 602 ( 4.4A)
PG4  A 602 (-3.4A)
 1.21A 2bxqA-5dqfA:
41.5		 2bxqA-5dqfA:
76.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ed1 DOUBLE-STRANDED
RNA-SPECIFIC EDITASE
1

(Homo sapiens) 		PF02137
(A_deamin) 		5 LEU A 556
ILE A 545
SER A 517
ILE A 520
ALA A 521
 None
 0.96A 2bxqA-5ed1A:
undetectable		 2bxqA-5ed1A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fa1 PUTATIVE N-ACETYL
GLUCOSAMINYL
TRANSFERASE

(Raoultella
terrigena) 		PF05159
(Capsule_synth) 		6 LEU A 341
LEU A 204
LEU A 201
ILE A 307
ILE A 324
ALA A 336
 None
 1.42A 2bxqA-5fa1A:
undetectable		 2bxqA-5fa1A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fei DISTAL TUBE PROTEIN

(Bacillus virus
phi29) 		PF16838
(Caud_tail_N) 		5 LEU A 174
LEU A 239
ILE A 252
ILE A 408
ALA A 407
 None
 0.94A 2bxqA-5feiA:
undetectable		 2bxqA-5feiA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fjj BETA-GLUCOSIDASE

(Aspergillus
oryzae) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 LEU A 410
LEU A 501
ILE A 548
ILE A 583
ALA A 584
 None
 1.03A 2bxqA-5fjjA:
undetectable		 2bxqA-5fjjA:
21.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus) 		PF00273
(Serum_albumin) 		9 LEU A 219
ARG A 222
PHE A 223
LEU A 238
HIS A 242
ARG A 257
LEU A 260
SER A 287
ALA A 291
 None
 0.66A 2bxqA-5ghkA:
38.2		 2bxqA-5ghkA:
79.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus) 		PF00273
(Serum_albumin) 		8 LYS A 195
LEU A 219
PHE A 223
LEU A 238
ARG A 257
LEU A 260
SER A 287
ALA A 291
 None
 1.01A 2bxqA-5ghkA:
38.2		 2bxqA-5ghkA:
79.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus) 		PF00273
(Serum_albumin) 		8 LYS A 199
ARG A 222
PHE A 223
HIS A 242
ARG A 257
LEU A 260
SER A 287
ALA A 291
 None
 1.03A 2bxqA-5ghkA:
38.2		 2bxqA-5ghkA:
79.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdh TOLL-LIKE RECEPTOR 8

(Homo sapiens) 		PF13855
(LRR_8) 		5 LEU A 413
PHE A 417
LEU A 382
LEU A 401
ILE A 399
 None
 1.00A 2bxqA-5hdhA:
undetectable		 2bxqA-5hdhA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlc 50S RIBOSOMAL
PROTEIN L23,
CHLOROPLASTIC

(Spinacia
oleracea) 		PF00276
(Ribosomal_L23) 		5 LEU V 187
LEU V 178
ILE V 176
SER V 152
ILE V 151
 None
 1.03A 2bxqA-5mlcV:
undetectable		 2bxqA-5mlcV:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n8n EVPB FAMILY TYPE VI
SECRETION PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 5 LYS B 123
LEU B 242
PHE B 350
LEU B 179
LEU B 231
 None
 0.98A 2bxqA-5n8nB:
undetectable		 2bxqA-5n8nB:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT) 		5 LEU T3171
LEU T3141
ILE T3137
ILE T3159
ALA T3160
 None
 1.00A 2bxqA-5ojsT:
undetectable		 2bxqA-5ojsT:
9.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus) 		no annotation 9 LEU A 218
LEU A 237
HIS A 241
ARG A 256
LEU A 259
ILE A 263
SER A 286
ILE A 289
ALA A 290
 None
 0.75A 2bxqA-5oriA:
40.2		 2bxqA-5oriA:
74.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus) 		no annotation 9 LEU A 218
PHE A 222
LEU A 237
HIS A 241
LEU A 259
ILE A 263
SER A 286
ILE A 289
ALA A 290
 None
 0.67A 2bxqA-5oriA:
40.2		 2bxqA-5oriA:
74.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		no annotation 6 LEU A 938
PHE A 937
LEU A 788
LEU A 867
ILE A 871
ILE A 915
 None
 1.32A 2bxqA-5vilA:
undetectable		 2bxqA-5vilA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w6l RTX
REPEAT-CONTAINING
CYTOTOXIN

(Vibrio
vulnificus) 		no annotation 5 LEU A3598
LEU A3620
HIS A3624
LEU A3638
ILE A3642
 LEU  A3598 ( 0.6A)
LEU  A3620 ( 0.6A)
HIS  A3624 ( 1.0A)
LEU  A3638 ( 0.6A)
ILE  A3642 ( 0.7A)
 1.01A 2bxqA-5w6lA:
3.4		 2bxqA-5w6lA:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wvg CHITINASE

(Ostrinia
furnacalis) 		no annotation 6 LEU A 661
PHE A 613
LEU A 665
LEU A 642
ILE A 603
ALA A 685
 None
 1.41A 2bxqA-5wvgA:
undetectable		 2bxqA-5wvgA:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xsq NUCLEOPROTEIN

(Marburg
marburgvirus) 		PF05505
(Ebola_NP) 		5 LEU A  43
PHE A 116
LEU A  36
ILE A 169
ALA A  25
 None
 1.01A 2bxqA-5xsqA:
2.6		 2bxqA-5xsqA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 9 LEU A 219
PHE A 223
LEU A 238
HIS A 242
ARG A 257
LEU A 260
ILE A 264
SER A 287
ILE A 290
 None
 0.65A 2bxqA-5yxeA:
37.8		 2bxqA-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 9 LYS A 199
LEU A 219
PHE A 223
HIS A 242
ARG A 257
LEU A 260
ILE A 264
SER A 287
ILE A 290
 None
 0.92A 2bxqA-5yxeA:
37.8		 2bxqA-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvs PUTATIVE CORE
PROTEIN NTPASE/VP5

(Aquareovirus C) 		no annotation 5 LEU 4  27
PHE 4  37
LEU 4 209
ILE 4   4
ALA 4 243
 None
 0.95A 2bxqA-5zvs4:
undetectable		 2bxqA-5zvs4:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eti ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2

(Homo sapiens) 		no annotation 5 LEU A  75
PHE A 253
LEU A 228
ILE A 249
ILE A 242
 None
 0.95A 2bxqA-6etiA:
undetectable		 2bxqA-6etiA:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ez8 HUNTINGTIN

(Homo sapiens) 		no annotation 5 LEU A1614
LEU A1630
LEU A1581
ILE A1575
ILE A1606
 None
 1.04A 2bxqA-6ez8A:
undetectable		 2bxqA-6ez8A:
6.81