SIMILAR PATTERNS OF AMINO ACIDS FOR 2BXQ_A_IMNA2001

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bge GRANULOCYTE
COLONY-STIMULATING
FACTOR

(Canis lupus) 		PF16647
(GCSF) 		5 ALA A 144
PHE A 145
ALA A 149
LEU A 153
LEU A  51
 None
 0.85A 2bxqA-1bgeA:
2.3		 2bxqA-1bgeA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fsu N-ACETYLGALACTOSAMIN
E-4-SULFATASE

(Homo sapiens) 		PF00884
(Sulfatase) 		5 ALA A 276
ALA A 219
ARG A 218
LEU A 222
LEU A 234
 NAG  A 600 (-3.6A)
None
None
None
None
 1.09A 2bxqA-1fsuA:
undetectable		 2bxqA-1fsuA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fw8 PHOSPHOGLYCERATE
KINASE

(Saccharomyces
cerevisiae) 		PF00162
(PGK) 		5 ALA A 257
PHE A 134
ALA A 136
LEU A 138
LEU A 153
 None
 1.05A 2bxqA-1fw8A:
undetectable		 2bxqA-1fw8A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0n RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Mus musculus) 		PF00268
(Ribonuc_red_sm) 		5 ALA A 231
PHE A 229
TRP A 214
ALA A 211
LEU A 212
 None
 1.05A 2bxqA-1h0nA:
undetectable		 2bxqA-1h0nA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iz1 LYSR-TYPE REGULATORY
PROTEIN

(Cupriavidus
necator) 		PF00126
(HTH_1)
PF03466
(LysR_substrate) 		5 ALA A  63
PHE A  64
ALA A  68
LEU A  72
LEU A   6
 None
 1.00A 2bxqA-1iz1A:
undetectable		 2bxqA-1iz1A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j93 UROPORPHYRINOGEN
DECARBOXYLASE

(Nicotiana
tabacum) 		PF01208
(URO-D) 		5 ALA A 341
PHE A 343
ALA A 347
LEU A 350
LEU A 325
 None
 1.16A 2bxqA-1j93A:
undetectable		 2bxqA-1j93A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kpl PUTATIVE CLC FAMILY,
CHLORINE TRANSPORT
PROTEIN

(Salmonella
enterica) 		PF00654
(Voltage_CLC) 		5 ALA A 370
PHE A 371
ALA A 375
LEU A 254
LEU A 334
 None
 1.09A 2bxqA-1kplA:
0.0		 2bxqA-1kplA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l2u OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Escherichia
coli) 		PF00215
(OMPdecase) 		5 ALA A  82
PHE A  74
ALA A  88
LEU A  91
LEU A  70
 None
 1.17A 2bxqA-1l2uA:
undetectable		 2bxqA-1l2uA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lgy TRIACYLGLYCEROL
LIPASE

(Rhizopus niveus) 		PF01764
(Lipase_3) 		6 SER A 115
ALA A 149
PHE A  80
ALA A 154
LEU A 158
LEU A  78
 None
 1.36A 2bxqA-1lgyA:
undetectable		 2bxqA-1lgyA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nne DNA MISMATCH REPAIR
PROTEIN MUTS

(Thermus
aquaticus) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		5 ALA A  77
PHE A  78
ALA A  82
LEU A  86
LEU A 116
 None
 1.11A 2bxqA-1nneA:
0.0		 2bxqA-1nneA:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ovm INDOLE-3-PYRUVATE
DECARBOXYLASE

(Enterobacter
cloacae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 ALA A 197
PHE A 198
ALA A 202
LEU A 206
LEU A 331
 None
 0.52A 2bxqA-1ovmA:
undetectable		 2bxqA-1ovmA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pem RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 2
ALPHA CHAIN

(Salmonella
enterica) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF08343
(RNR_N) 		5 SER A 287
ALA A 208
ALA A 197
LEU A 198
LEU A 387
 None
 0.86A 2bxqA-1pemA:
2.7		 2bxqA-1pemA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pg7 MURINE ANTIBODY 6A6
FAB FRAGMENT

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 SER X  74
PHE X  29
ALA X  24
LEU X   4
LEU X  34
 None
 1.09A 2bxqA-1pg7X:
undetectable		 2bxqA-1pg7X:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q15 CARA

(Pectobacterium
carotovorum) 		PF00733
(Asn_synthase)
PF09147
(DUF1933) 		5 ALA A 287
ALA A 256
ARG A 260
LEU A 257
LEU A 253
 None
 1.08A 2bxqA-1q15A:
undetectable		 2bxqA-1q15A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rur IMMUNOGLOBULIN 13G5,
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 SER H  74
PHE H  29
ALA H  24
LEU H   4
LEU H  34
 None
 1.09A 2bxqA-1rurH:
undetectable		 2bxqA-1rurH:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE GAMMA
SUBUNIT

(Thauera
aromatica) 		PF00111
(Fer2)
PF01799
(Fer2_2) 		5 ALA C  48
ALA C  60
ARG C  58
LEU C  24
LEU C  28
 FES  C1908 ( 4.7A)
None
None
None
None
 1.13A 2bxqA-1sb3C:
2.5		 2bxqA-1sb3C:
14.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		7 ALA A 210
PHE A 211
ALA A 215
ARG A 218
LEU A 219
LEU A 238
LEU A 481
 DKA  A1002 (-3.3A)
None
None
CIT  A2001 (-4.0A)
None
DKA  A1003 (-4.3A)
None
 0.43A 2bxqA-1tf0A:
38.1		 2bxqA-1tf0A:
99.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens) 		PF00273
(Serum_albumin) 		5 LYS A 199
ARG A 218
LEU A 219
LEU A 238
LEU A 481
 CIT  A2001 ( 2.7A)
CIT  A2001 (-4.0A)
None
DKA  A1003 (-4.3A)
None
 1.01A 2bxqA-1tf0A:
38.1		 2bxqA-1tf0A:
99.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tpy METHOXY MYCOLIC ACID
SYNTHASE 2

(Mycobacterium
tuberculosis) 		PF02353
(CMAS) 		5 PHE A 150
ALA A 154
LEU A 158
LEU A 164
LEU A   5
 None
 1.08A 2bxqA-1tpyA:
undetectable		 2bxqA-1tpyA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vge TR1.9 FAB

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 SER H  76
PHE H  30
ALA H  25
LEU H   5
LEU H  35
 None
 1.16A 2bxqA-1vgeH:
undetectable		 2bxqA-1vgeH:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdy 2-5A-DEPENDENT
RIBONUCLEASE

(Homo sapiens) 		PF12796
(Ank_2)
PF13857
(Ank_5) 		5 ALA A 128
PHE A 129
ALA A 133
LEU A 187
LEU A 108
 None
 1.03A 2bxqA-1wdyA:
undetectable		 2bxqA-1wdyA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x77 CONSERVED
HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF03358
(FMN_red) 		5 ALA A  79
ALA A 112
LEU A 142
LEU A 178
LEU A  91
 None
 0.95A 2bxqA-1x77A:
undetectable		 2bxqA-1x77A:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9k IAA
ACETYLTRANSFERASE

(Bacillus cereus) 		PF00583
(Acetyltransf_1) 		5 SER A 106
ALA A  66
LEU A  17
LEU A  20
LEU A 110
 None
 1.07A 2bxqA-1y9kA:
undetectable		 2bxqA-1y9kA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zc6 PROBABLE
N-ACETYLGLUCOSAMINE
KINASE

(Chromobacterium
violaceum) 		PF01869
(BcrAD_BadFG) 		5 LYS A   8
ALA A  74
ALA A  78
LEU A 291
LEU A  13
 None
 1.11A 2bxqA-1zc6A:
undetectable		 2bxqA-1zc6A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dht 409AA LONG
HYPOTHETICAL
NADP-DEPENDENT
ISOCITRATE
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00180
(Iso_dh) 		5 SER A 195
ALA A 233
PHE A 234
ALA A 238
LEU A 291
 None
 0.78A 2bxqA-2dhtA:
undetectable		 2bxqA-2dhtA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ffi 2-PYRONE-4,6-DICARBO
XYLIC ACID
HYDROLASE, PUTATIVE

(Pseudomonas
putida) 		PF04909
(Amidohydro_2) 		5 PHE A 168
ALA A 215
ARG A 216
LEU A 212
LEU A 186
 None
 1.10A 2bxqA-2ffiA:
undetectable		 2bxqA-2ffiA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fo1 LIN-12 PROTEIN

(Caenorhabditis
elegans) 		PF00023
(Ank)
PF12796
(Ank_2) 		5 LYS E1236
ALA E1215
ALA E1210
LEU E1167
LEU E1247
 None
 1.14A 2bxqA-2fo1E:
undetectable		 2bxqA-2fo1E:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g7s TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Agrobacterium
fabrum) 		PF00440
(TetR_N) 		5 PHE A  27
ALA A  15
ARG A  16
LEU A  12
LEU A  53
 None
 1.17A 2bxqA-2g7sA:
3.1		 2bxqA-2g7sA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mpa MN12H2
IGG2A-KAPPA,HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 SER H  75
PHE H  29
ALA H  24
LEU H   4
LEU H  34
 None
 1.04A 2bxqA-2mpaH:
undetectable		 2bxqA-2mpaH:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mtc DECORIN-BINDING
PROTEIN A

(Borreliella
burgdorferi) 		PF02352
(Decorin_bind) 		5 ALA A  92
PHE A  95
ALA A  42
LEU A  38
LEU A 129
 None
 1.03A 2bxqA-2mtcA:
undetectable		 2bxqA-2mtcA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyh PUTATIVE DIOXYGENASE

(Paraburkholderia
xenovorans) 		PF08883
(DOPA_dioxygen) 		5 ALA A 101
ALA A  14
LEU A  61
LEU A  75
LEU A 110
 None
 1.17A 2bxqA-2nyhA:
undetectable		 2bxqA-2nyhA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q83 YTAA PROTEIN

(Bacillus
subtilis) 		PF01636
(APH) 		5 ALA A  81
PHE A  83
ALA A  87
LEU A  91
LEU A 235
 None
 1.17A 2bxqA-2q83A:
undetectable		 2bxqA-2q83A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgn TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE

(Bacillus
halodurans) 		PF01715
(IPPT) 		6 ALA A 107
PHE A  77
ALA A  81
LEU A  84
LEU A  62
LEU A 114
 None
 1.47A 2bxqA-2qgnA:
undetectable		 2bxqA-2qgnA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v82 2-DEHYDRO-3-DEOXY-6-
PHOSPHOGALACTONATE
ALDOLASE

(Escherichia
coli) 		PF01081
(Aldolase) 		5 SER A 130
ALA A 109
ALA A 114
LEU A 118
LEU A 145
 None
 1.17A 2bxqA-2v82A:
undetectable		 2bxqA-2v82A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2

(Saccharomyces
cerevisiae) 		PF04072
(LCM)
PF13418
(Kelch_4) 		5 ALA A 542
ALA A 570
LEU A 590
LEU A 631
LEU A 506
 None
 1.12A 2bxqA-2zwaA:
undetectable		 2bxqA-2zwaA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3da1 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Bacillus
halodurans) 		PF01266
(DAO)
PF16901
(DAO_C) 		5 LYS A 242
SER A 241
PHE A 360
ALA A 370
LEU A 366
 None
 1.06A 2bxqA-3da1A:
undetectable		 2bxqA-3da1A:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e10 PUTATIVE NADH
OXIDASE

(Clostridium
acetobutylicum) 		PF00881
(Nitroreductase) 		5 ALA A 110
ALA A  72
LEU A  47
LEU A  56
LEU A 100
 None
None
None
EDO  A 503 (-4.2A)
None
 1.10A 2bxqA-3e10A:
undetectable		 2bxqA-3e10A:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmf DETHIOBIOTIN
SYNTHETASE

(Mycobacterium
tuberculosis) 		PF13500
(AAA_26) 		5 ALA A  26
PHE A 216
ALA A  21
LEU A 196
LEU A 104
 None
 1.13A 2bxqA-3fmfA:
undetectable		 2bxqA-3fmfA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8a RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G

(Thermus
thermophilus) 		PF02527
(GidB) 		5 ALA A 118
PHE A 119
ALA A 123
LEU A 127
LEU A  39
 None
 1.10A 2bxqA-3g8aA:
2.3		 2bxqA-3g8aA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h6z POLYCOMB PROTEIN
SFMBT

(Drosophila
melanogaster) 		PF02820
(MBT) 		5 SER A 724
ALA A 707
PHE A 722
ALA A 751
ARG A 700
 None
 1.17A 2bxqA-3h6zA:
undetectable		 2bxqA-3h6zA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h8n KILLER CELL
IMMUNOGLOBULIN-LIKE
RECEPTOR 2DS4

(Homo sapiens) 		PF00047
(ig) 		5 SER A 180
ALA A 152
ARG A 148
LEU A 126
LEU A 110
 None
 1.09A 2bxqA-3h8nA:
undetectable		 2bxqA-3h8nA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hc4 IMMUNOGLOBULIN IGG1
FAB, HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 SER H  75
PHE H  29
ALA H  24
LEU H   4
LEU H  34
 None
 1.08A 2bxqA-3hc4H:
undetectable		 2bxqA-3hc4H:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdj PROBABLE ORNITHINE
CYCLODEAMINASE

(Bordetella
pertussis) 		PF02423
(OCD_Mu_crystall) 		6 LYS A 100
ALA A 292
ALA A 297
ARG A 300
LEU A 301
LEU A  22
 None
 1.29A 2bxqA-3hdjA:
undetectable		 2bxqA-3hdjA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hww 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE-1-CARBOXYLA
TE SYNTHASE

(Escherichia
coli) 		PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
PF16582
(TPP_enzyme_M_2) 		5 PHE A 170
TRP A  10
ALA A  11
LEU A  15
LEU A  37
 None
 0.98A 2bxqA-3hwwA:
undetectable		 2bxqA-3hwwA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3it4 ARGININE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
ARGJ ALPHA CHAIN
ARGININE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
ARGJ BETA CHAIN

(Mycobacterium
tuberculosis) 		PF01960
(ArgJ) 		5 ALA B 211
ALA A  51
LEU A  72
LEU A  77
LEU B 260
 None
None
GOL  A 500 (-4.9A)
None
None
 1.18A 2bxqA-3it4B:
undetectable		 2bxqA-3it4B:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k20 OXIDOREDUCTASE

(Corynebacterium
diphtheriae) 		PF03358
(FMN_red) 		5 SER A  89
ALA A 115
ALA A   9
LEU A  11
LEU A 130
 None
 1.09A 2bxqA-3k20A:
undetectable		 2bxqA-3k20A:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l5a NADH/FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE

(Staphylococcus
aureus) 		PF00724
(Oxidored_FMN) 		5 SER A 185
ALA A 194
ALA A 201
LEU A 205
LEU A 249
 None
 1.08A 2bxqA-3l5aA:
undetectable		 2bxqA-3l5aA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m49 TRANSKETOLASE

(Bacillus
anthracis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 ALA A 418
ALA A 131
LEU A 135
LEU A 428
LEU A 171
 None
 1.17A 2bxqA-3m49A:
undetectable		 2bxqA-3m49A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkh NITROALKANE OXIDASE

(Podospora
anserina) 		PF00441
(Acyl-CoA_dh_1)
PF02771
(Acyl-CoA_dh_N) 		5 ALA A 274
PHE A 270
ALA A 269
LEU A 132
LEU A 353
 None
 1.05A 2bxqA-3mkhA:
2.7		 2bxqA-3mkhA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0g ISOPRENE SYNTHASE

(Populus tremula
x Populus alba) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		5 SER A 198
ALA A 152
PHE A 155
ALA A 169
LEU A 194
 None
 1.12A 2bxqA-3n0gA:
2.2		 2bxqA-3n0gA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0r RESPONSE REGULATOR

(Caulobacter
vibrioides) 		PF00072
(Response_reg) 		5 ALA A  93
ALA A  20
ARG A  19
LEU A 105
LEU A  89
 None
 1.11A 2bxqA-3n0rA:
undetectable		 2bxqA-3n0rA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sb4 HYPOTHETICAL LEUCINE
RICH REPEAT PROTEIN

(Bacteroides
thetaiotaomicron) 		PF13306
(LRR_5) 		5 ALA A 139
PHE A 109
LEU A  56
LEU A  64
LEU A 164
 None
 1.12A 2bxqA-3sb4A:
undetectable		 2bxqA-3sb4A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t9p MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Roseovarius sp.
TM1035) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 PHE A  65
ALA A  70
LEU A  74
LEU A  28
LEU A 100
 None
 0.96A 2bxqA-3t9pA:
undetectable		 2bxqA-3t9pA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3voo FATTY ACID
ALPHA-HYDROXYLASE

(Sphingomonas
paucimobilis) 		PF00067
(p450) 		5 PHE A 133
ALA A 254
LEU A 257
LEU A 378
LEU A 401
 None
 1.13A 2bxqA-3vooA:
2.3		 2bxqA-3vooA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpo RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2

(Homo sapiens) 		PF00268
(Ribonuc_red_sm) 		5 ALA A 230
PHE A 228
TRP A 213
ALA A 210
LEU A 211
 None
 1.07A 2bxqA-3vpoA:
undetectable		 2bxqA-3vpoA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4acq ALPHA-2-MACROGLOBULI
N

(Homo sapiens) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		5 SER A1026
TRP A1069
ALA A1066
LEU A1067
LEU A1046
 None
 1.14A 2bxqA-4acqA:
undetectable		 2bxqA-4acqA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4djn RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT M2 B

(Homo sapiens) 		PF00268
(Ribonuc_red_sm) 		5 ALA A 192
PHE A 190
TRP A 175
ALA A 172
LEU A 173
 None
 1.11A 2bxqA-4djnA:
undetectable		 2bxqA-4djnA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g8k 2-5A-DEPENDENT
RIBONUCLEASE

(Homo sapiens) 		PF12796
(Ank_2)
PF13857
(Ank_5) 		5 ALA A 128
PHE A 129
ALA A 133
LEU A 187
LEU A 108
 None
 1.02A 2bxqA-4g8kA:
undetectable		 2bxqA-4g8kA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN

(Pseudomonas) 		PF01804
(Penicil_amidase) 		5 ALA B 338
PHE B 339
ALA B 402
LEU B 399
LEU B 410
 None
 1.13A 2bxqA-4hstB:
undetectable		 2bxqA-4hstB:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jbb PUTATIVE GLUTATHIONE
S-TRANSFERASE

(Klebsiella
pneumoniae) 		PF13417
(GST_N_3)
PF14834
(GST_C_4) 		6 ALA A 147
PHE A 146
ALA A 142
ARG A 139
LEU A 134
LEU A 178
 None
 1.40A 2bxqA-4jbbA:
undetectable		 2bxqA-4jbbA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mbg CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1

(Aspergillus
fumigatus) 		PF00432
(Prenyltrans) 		5 ALA B 315
PHE B 316
ALA B 320
LEU B 324
LEU B 345
 None
 0.92A 2bxqA-4mbgB:
undetectable		 2bxqA-4mbgB:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nef AQUAPORIN-2

(Homo sapiens) 		PF00230
(MIP) 		5 ALA A  45
PHE A  48
ALA A  31
LEU A  32
LEU A  28
 None
 1.05A 2bxqA-4nefA:
undetectable		 2bxqA-4nefA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nhb TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT

(Desulfovibrio
desulfuricans) 		PF03480
(DctP) 		5 ALA A 327
ALA A 118
ARG A 119
LEU A 115
LEU A 235
 None
None
None
IOD  A 403 (-4.4A)
None
 1.12A 2bxqA-4nhbA:
undetectable		 2bxqA-4nhbA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o0m CIRCADIAN CLOCK
PROTEIN KINASE KAIC

(Thermosynechococcus
elongatus) 		PF06745
(ATPase) 		5 SER A 282
PHE A 411
ALA A 286
LEU A 440
LEU A 297
 None
 1.01A 2bxqA-4o0mA:
undetectable		 2bxqA-4o0mA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1o RIBONUCLEASE L

(Sus scrofa) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		5 ALA A 126
PHE A 127
ALA A 131
LEU A 185
LEU A 106
 None
 1.13A 2bxqA-4o1oA:
2.4		 2bxqA-4o1oA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oav PROTEIN (RNASE L)

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		5 ALA B 128
PHE B 129
ALA B 133
LEU B 187
LEU B 108
 None
 1.06A 2bxqA-4oavB:
2.6		 2bxqA-4oavB:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oj2 AQUAPORIN-2

(Homo sapiens) 		PF00230
(MIP) 		5 ALA X  45
PHE X  48
ALA X  31
LEU X  32
LEU X  28
 None
 1.07A 2bxqA-4oj2X:
undetectable		 2bxqA-4oj2X:
21.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus) 		PF00273
(Serum_albumin) 		6 ALA A 210
ALA A 215
ARG A 218
LEU A 219
LEU A 238
LEU A 481
 None
 0.59A 2bxqA-4po0A:
40.4		 2bxqA-4po0A:
74.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q88 UNCHARACTERIZED
PROTEIN

(Bacteroides
vulgatus) 		PF07470
(Glyco_hydro_88) 		5 ALA A 360
PHE A 361
ALA A 365
ARG A 368
LEU A  30
 None
 1.11A 2bxqA-4q88A:
undetectable		 2bxqA-4q88A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qcc 2-DEHYDRO-3-DEOXY-6-
PHOSPHOGALACTONATE
ALDOLASE,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CHIMERA

(Escherichia
coli) 		PF01081
(Aldolase)
PF01346
(FKBP_N) 		5 SER A 130
ALA A 109
ALA A 114
LEU A 118
LEU A 145
 None
 1.17A 2bxqA-4qccA:
2.5		 2bxqA-4qccA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3k SPORE GERMINATION
PROTEIN YAAH

(Bacillus
megaterium) 		PF00704
(Glyco_hydro_18)
PF01476
(LysM) 		5 ALA A 230
PHE A 231
ALA A 235
ARG A 238
LEU A 239
 None
 0.66A 2bxqA-4s3kA:
undetectable		 2bxqA-4s3kA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tlg SEC14-LIKE PROTEIN 4

(Homo sapiens) 		PF00650
(CRAL_TRIO) 		5 ALA A 194
ALA A 201
LEU A 204
LEU A 163
LEU A 394
 None
11A  A 518 ( 4.1A)
None
EDO  A 503 (-4.4A)
None
 1.13A 2bxqA-4tlgA:
undetectable		 2bxqA-4tlgA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 SER A2834
ALA A2777
LEU A2828
LEU A2855
LEU A2810
 None
 1.13A 2bxqA-4z37A:
undetectable		 2bxqA-4z37A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa4 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE F

(Pseudomonas
aeruginosa) 		PF00497
(SBP_bac_3)
PF01464
(SLT) 		5 ALA B 104
ALA B 106
LEU B 110
LEU B  93
LEU B  45
 None
 1.05A 2bxqA-5aa4B:
undetectable		 2bxqA-5aa4B:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c1i TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI

(Thermus
thermophilus) 		PF08704
(GCD14) 		5 ALA A 168
ALA A 181
ARG A 251
LEU A 178
LEU A  89
 None
 1.14A 2bxqA-5c1iA:
undetectable		 2bxqA-5c1iA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ch8 MONO- AND
DIACYLGLYCEROL
LIPASE

(Penicillium
cyclopium) 		PF01764
(Lipase_3)
PF03893
(Lipase3_N) 		5 ALA A 149
PHE A  80
ALA A 154
LEU A 158
LEU A  78
 None
 1.00A 2bxqA-5ch8A:
undetectable		 2bxqA-5ch8A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwa ANTHRANILATE
SYNTHASE COMPONENT 1

(Mycobacterium
tuberculosis) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		5 ALA A 134
PHE A 133
LEU A  77
LEU A 104
LEU A 438
 None
None
None
None
GOL  A 605 (-3.9A)
 1.06A 2bxqA-5cwaA:
undetectable		 2bxqA-5cwaA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmy BETA-GALACTOSIDASE

(Bifidobacterium
bifidum) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		5 ALA A 773
ALA A 847
ARG A 838
LEU A 819
LEU A 771
 None
 1.14A 2bxqA-5dmyA:
undetectable		 2bxqA-5dmyA:
19.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		5 ALA A 209
ARG A 217
LEU A 218
LEU A 237
LEU A 480
 CZE  A 613 ( 4.4A)
CL  A 617 ( 4.6A)
None
PG4  A 602 (-4.7A)
None
 0.53A 2bxqA-5dqfA:
41.5		 2bxqA-5dqfA:
76.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e3c DIPEPTIDYL PEPTIDASE
3

(Homo sapiens) 		PF03571
(Peptidase_M49) 		5 ALA A 265
ALA A  34
LEU A 379
LEU A  26
LEU A 278
 None
 1.03A 2bxqA-5e3cA:
3.6		 2bxqA-5e3cA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ejj UFM1-SPECIFIC
PROTEASE

(Caenorhabditis
elegans) 		PF07910
(Peptidase_C78) 		5 SER A 142
ALA A 274
PHE A 275
ALA A 279
LEU A 166
 None
 1.14A 2bxqA-5ejjA:
undetectable		 2bxqA-5ejjA:
21.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus) 		PF00273
(Serum_albumin) 		6 ALA A 210
PHE A 211
ARG A 218
LEU A 219
LEU A 238
LEU A 481
 None
 0.58A 2bxqA-5ghkA:
38.2		 2bxqA-5ghkA:
79.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gl6 RIBOSOME MATURATION
FACTOR RIMP

(Mycolicibacterium
smegmatis) 		PF02576
(DUF150)
PF17384
(DUF150_C) 		5 ALA A 123
ALA A 173
ARG A 107
LEU A 170
LEU A 113
 None
 1.12A 2bxqA-5gl6A:
undetectable		 2bxqA-5gl6A:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 ALA B 246
PHE B 245
LEU B 261
LEU B 217
LEU B 272
 None
 1.03A 2bxqA-5gqrB:
undetectable		 2bxqA-5gqrB:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdh TOLL-LIKE RECEPTOR 8

(Homo sapiens) 		PF13855
(LRR_8) 		5 ALA A 528
PHE A 526
LEU A 556
LEU A 550
LEU A 504
 None
 1.11A 2bxqA-5hdhA:
undetectable		 2bxqA-5hdhA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxa ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Paraburkholderia
xenovorans) 		PF00982
(Glyco_transf_20) 		5 ALA A 306
ARG A 272
LEU A 273
LEU A 279
LEU A 354
 None
 1.14A 2bxqA-5hxaA:
undetectable		 2bxqA-5hxaA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iys PHYTOENE SYNTHASE

(Enterococcus
hirae) 		PF00494
(SQS_PSY) 		5 ALA A  50
PHE A  51
ALA A  55
LEU A  68
LEU A 110
 None
 1.12A 2bxqA-5iysA:
2.8		 2bxqA-5iysA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l26 NUCLEOSIDE PERMEASE

(Neisseria
wadsworthii) 		PF01773
(Nucleos_tra2_N)
PF07662
(Nucleos_tra2_C)
PF07670
(Gate) 		5 PHE A 174
ALA A 400
LEU A 403
LEU A 220
LEU A 375
 None
 1.11A 2bxqA-5l26A:
undetectable		 2bxqA-5l26A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5loi RAD26

(Thermothelomyces
thermophila) 		PF12331
(DUF3636) 		5 ALA A 663
PHE A 656
ALA A 655
ARG A 651
LEU A 767
 None
 1.15A 2bxqA-5loiA:
undetectable		 2bxqA-5loiA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4j HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 SER H  74
PHE H  28
ALA H  23
LEU H   3
LEU H  33
 None
 1.13A 2bxqA-5n4jH:
undetectable		 2bxqA-5n4jH:
16.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus) 		no annotation 5 ALA A 209
ARG A 217
LEU A 218
LEU A 237
LEU A 480
 None
 0.95A 2bxqA-5oriA:
40.2		 2bxqA-5oriA:
74.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t2x UNCHARACTERIZED
PROTEIN LPG1670

(Legionella
pneumophila) 		no annotation 5 ALA A 204
ARG A 205
LEU A 201
LEU A 174
LEU A 270
 None
 1.05A 2bxqA-5t2xA:
undetectable		 2bxqA-5t2xA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5was HOMOSERINE KINASE

(Corynebacterium
glutamicum) 		no annotation 5 SER C 248
ALA C 261
ALA A 181
LEU C 294
LEU A 100
 None
 1.11A 2bxqA-5wasC:
undetectable		 2bxqA-5wasC:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxp LYSR-TYPE REGULATORY
PROTEIN

(Cupriavidus
necator) 		no annotation 5 ALA A  63
PHE A  64
ALA A  68
LEU A  72
LEU A   6
 None
 0.94A 2bxqA-5xxpA:
undetectable		 2bxqA-5xxpA:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 6 ALA A 210
PHE A 211
ARG A 218
LEU A 219
LEU A 238
LEU A 481
 None
 0.54A 2bxqA-5yxeA:
37.8		 2bxqA-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus) 		no annotation 5 LYS A 199
ALA A 210
ARG A 218
LEU A 219
LEU A 481
 None
 0.96A 2bxqA-5yxeA:
37.8		 2bxqA-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zbi PEPTIDE ASPARAGINYL
LIGASE

(Viola
canadensis) 		no annotation 5 SER A 227
ALA A 211
PHE A 214
LEU A 180
LEU A 185
 None
 1.06A 2bxqA-5zbiA:
undetectable		 2bxqA-5zbiA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvt C-TERMINUS OF OUTER
CAPSID PROTEIN VP5

(Aquareovirus C) 		no annotation 5 ALA B 572
PHE B 576
ALA B 583
LEU B 584
LEU B 514
 None
 1.03A 2bxqA-5zvtB:
undetectable		 2bxqA-5zvtB:
8.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6apg DISD PROTEIN

(Sorangium
cellulosum) 		no annotation 5 PHE A  94
ALA A  66
LEU A  67
LEU A  27
LEU A  82
 None
 1.10A 2bxqA-6apgA:
1.6		 2bxqA-6apgA:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cdz THYMIDYLATE SYNTHASE

(Escherichia
coli) 		no annotation 5 ALA A 148
PHE A 150
ARG A  99
LEU A  63
LEU A 184
 None
 1.16A 2bxqA-6cdzA:
undetectable		 2bxqA-6cdzA:
9.92