SIMILAR PATTERNS OF AMINO ACIDS FOR 2BXP_A_P1ZA3001

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bt4 PHOSPHOSERINE
AMINOTRANSFERASE


(Bacillus
circulans)
PF00266
(Aminotran_5)
5 LEU A  58
LEU A  62
LEU A 261
ILE A 255
SER A 180
None
0.99A 2bxpA-1bt4A:
undetectable
2bxpA-1bt4A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cbk PROTEIN
(7,8-DIHYDRO-6-HYDRO
XYMETHYLPTERIN-PYROP
HOSPHOKINASE)


(Haemophilus
influenzae)
PF01288
(HPPK)
5 LEU A  94
LEU A  19
LEU A  23
ILE A  26
ALA A   7
None
1.12A 2bxpA-1cbkA:
undetectable
2bxpA-1cbkA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hbr PROTEIN (HEMOGLOBIN
D)


(Gallus gallus)
PF00042
(Globin)
5 PHE A 128
LEU A 136
HIS A  87
ALA A  79
ALA A  65
None
None
HEM  A 142 (-3.3A)
None
HEM  A 142 ( 3.9A)
0.90A 2bxpA-1hbrA:
undetectable
2bxpA-1hbrA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ipa RNA 2'-O-RIBOSE
METHYLTRANSFERASE


(Thermus
thermophilus)
PF00588
(SpoU_methylase)
PF08032
(SpoU_sub_bind)
5 LEU A  74
LEU A  96
ALA A  34
ILE A  37
ALA A  67
None
1.03A 2bxpA-1ipaA:
undetectable
2bxpA-1ipaA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iuq GLYCEROL-3-PHOSPHATE
ACYLTRANSFERASE


(Cucurbita
moschata)
PF01553
(Acyltransferase)
PF14829
(GPAT_N)
5 LEU A 274
LEU A 305
LEU A 152
ALA A 160
ILE A 159
None
1.03A 2bxpA-1iuqA:
3.2
2bxpA-1iuqA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k8q TRIACYLGLYCEROL
LIPASE, GASTRIC


(Canis lupus)
PF00561
(Abhydrolase_1)
5 PHE A 121
TRP A 119
ARG A 106
ALA A  71
ALA A 265
None
1.25A 2bxpA-1k8qA:
undetectable
2bxpA-1k8qA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m32 2-AMINOETHYLPHOSPHON
ATE-PYRUVATE
AMINOTRANSFERASE


(Salmonella
enterica)
PF00266
(Aminotran_5)
5 LEU A  60
LEU A  46
LEU A 255
ALA A 254
ALA A 191
None
1.22A 2bxpA-1m32A:
undetectable
2bxpA-1m32A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1md7 C1R COMPLEMENT
SERINE PROTEASE


(Homo sapiens)
PF00084
(Sushi)
PF00089
(Trypsin)
5 LEU A 561
LEU A 475
LEU A 543
ALA A 542
ILE A 541
None
1.21A 2bxpA-1md7A:
undetectable
2bxpA-1md7A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nbw GLYCEROL DEHYDRATASE
REACTIVASE BETA
SUBUNIT


(Klebsiella
pneumoniae)
PF02288
(Dehydratase_MU)
5 LEU B 107
LEU B  74
ALA B  73
ILE B  64
ALA B  55
None
1.20A 2bxpA-1nbwB:
undetectable
2bxpA-1nbwB:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o60 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE


(Haemophilus
influenzae)
PF00793
(DAHP_synth_1)
5 LEU A 236
LEU A 229
ALA A 230
ILE A 270
SER A 227
None
1.13A 2bxpA-1o60A:
undetectable
2bxpA-1o60A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9j ALDEHYDE
DEHYDROGENASE,
CYTOSOLIC 1


(Elephantulus
edwardii)
PF00171
(Aldedh)
5 LEU A 175
LEU A  91
ALA A  92
ILE A  95
ALA A 128
None
1.13A 2bxpA-1o9jA:
undetectable
2bxpA-1o9jA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rq1 HYPOTHETICAL 65.0
KDA PROTEIN IN
COX14-COS3
INTERGENIC REGION
PRECURSOR


(Saccharomyces
cerevisiae)
PF04137
(ERO1)
5 PHE A  78
LEU A 289
LEU A 396
ALA A 369
ILE A 372
None
1.06A 2bxpA-1rq1A:
undetectable
2bxpA-1rq1A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s0h HEMOGLOBIN ALPHA
CHAIN


(Equus asinus)
PF00042
(Globin)
5 PHE A 128
LEU A 136
HIS A  87
ALA A  79
ALA A  65
None
None
HEM  A 142 (-3.3A)
None
HEM  A 142 (-3.6A)
0.97A 2bxpA-1s0hA:
2.3
2bxpA-1s0hA:
13.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens)
PF00273
(Serum_albumin)
10 PHE A 211
TRP A 214
LEU A 219
PHE A 223
LEU A 238
HIS A 242
LEU A 260
ALA A 261
ILE A 264
ALA A 291
None
None
None
None
DKA  A1003 (-4.3A)
DKA  A1003 (-3.7A)
None
None
None
CIT  A2001 ( 3.9A)
0.44A 2bxpA-1tf0A:
38.2
2bxpA-1tf0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tf0 SERUM ALBUMIN

(Homo sapiens)
PF00273
(Serum_albumin)
9 PHE A 211
TRP A 214
LEU A 219
PHE A 223
LEU A 238
HIS A 242
LEU A 260
SER A 287
ALA A 291
None
None
None
None
DKA  A1003 (-4.3A)
DKA  A1003 (-3.7A)
None
None
CIT  A2001 ( 3.9A)
0.62A 2bxpA-1tf0A:
38.2
2bxpA-1tf0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tu7 GLUTATHIONE
S-TRANSFERASE 2


(Onchocerca
volvulus)
PF02798
(GST_N)
PF14497
(GST_C_3)
5 LEU A 154
PHE A  90
LEU A 158
LEU A 125
ALA A 126
None
1.04A 2bxpA-1tu7A:
undetectable
2bxpA-1tu7A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wuf HYPOTHETICAL PROTEIN
LIN2664


(Listeria
innocua)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 LEU A1264
LEU A1120
ALA A1121
ILE A1124
ALA A1306
None
1.15A 2bxpA-1wufA:
undetectable
2bxpA-1wufA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xp8 RECA PROTEIN

(Deinococcus
radiodurans)
PF00154
(RecA)
5 LEU A  63
LEU A 235
LEU A  87
ALA A  88
ILE A  91
None
1.13A 2bxpA-1xp8A:
undetectable
2bxpA-1xp8A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjc AMINOPEPTIDASE AMPS

(Staphylococcus
aureus)
PF02073
(Peptidase_M29)
5 PHE A 341
TRP A 154
LEU A  15
ALA A  12
ILE A  43
None
1.16A 2bxpA-1zjcA:
undetectable
2bxpA-1zjcA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ztv HYPOTHETICAL PROTEIN

(Enterococcus
faecalis)
PF01904
(DUF72)
5 LEU A   4
PHE A 243
LEU A 262
ALA A 223
ILE A 222
None
0.83A 2bxpA-1ztvA:
undetectable
2bxpA-1ztvA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9i ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
BETA


(Staphylococcus
aureus)
PF01039
(Carboxyl_trans)
5 LEU B 161
PHE B 213
ALA B 110
ILE B 141
ALA B 164
None
0.99A 2bxpA-2f9iB:
undetectable
2bxpA-2f9iB:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ihs CG2944-PF, ISOFORM F

(Drosophila
melanogaster)
PF00622
(SPRY)
5 LEU A 208
LEU A 185
ALA A 184
SER A 193
ALA A 204
None
1.23A 2bxpA-2ihsA:
undetectable
2bxpA-2ihsA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v0s LR1

(Homo sapiens)
PF03372
(Exo_endo_phos)
5 LEU A  77
LEU A  54
LEU A  18
ILE A  15
ALA A  28
None
1.21A 2bxpA-2v0sA:
undetectable
2bxpA-2v0sA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vha PERIPLASMIC BINDING
TRANSPORT PROTEIN


(Shigella
flexneri)
PF00497
(SBP_bac_3)
5 LEU A  10
PHE A 222
LEU A  63
ILE A  19
ALA A  53
None
1.10A 2bxpA-2vhaA:
undetectable
2bxpA-2vhaA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vro ALDEHYDE
DEHYDROGENASE


(Paraburkholderia
xenovorans)
PF00171
(Aldedh)
5 PHE A 280
LEU A 313
LEU A 384
SER A 407
ALA A 409
None
1.12A 2bxpA-2vroA:
undetectable
2bxpA-2vroA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdv MYC-INDUCED NUCLEAR
ANTIGEN


(Homo sapiens)
PF08007
(Cupin_4)
5 LEU A 198
PHE A 234
LEU A 226
ILE A 187
ALA A 242
None
None
None
None
OGA  A 601 ( 4.2A)
1.18A 2bxpA-2xdvA:
undetectable
2bxpA-2xdvA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ybu ACIDIC MAMMALIAN
CHITINASE


(Homo sapiens)
PF00704
(Glyco_hydro_18)
5 PHE A 119
LEU A 127
LEU A  94
ALA A  95
ILE A  96
None
1.12A 2bxpA-2ybuA:
undetectable
2bxpA-2ybuA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfh GLUTAMATE
DEHYDROGENASE,
NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE,
GLUTAMATE
DEHYDROGENASE


(Escherichia
coli;
[Clostridium]
symbiosum)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
5 LEU A 214
LEU A 318
ALA A 317
ILE A 316
ALA A 366
None
1.19A 2bxpA-2yfhA:
undetectable
2bxpA-2yfhA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ygs APOPTOTIC PROTEASE
ACTIVATING FACTOR 1


(Homo sapiens)
PF00619
(CARD)
5 LEU A  87
LEU A  75
ALA A  53
ILE A  57
ALA A  15
None
1.17A 2bxpA-2ygsA:
undetectable
2bxpA-2ygsA:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zf5 GLYCEROL KINASE

(Thermococcus
kodakarensis)
PF00370
(FGGY_N)
PF02782
(FGGY_C)
5 LEU O 166
LEU O   8
ALA O  17
ILE O  59
ALA O  54
None
1.04A 2bxpA-2zf5O:
undetectable
2bxpA-2zf5O:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b89 16S RRNA METHYLASE

(Escherichia
coli)
PF07091
(FmrO)
5 LEU A 176
LEU A 191
LEU A 194
ILE A 110
ALA A 200
None
1.01A 2bxpA-3b89A:
2.6
2bxpA-3b89A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE


(Homo sapiens)
PF16113
(ECH_2)
5 PHE A 117
LEU A 124
LEU A  60
LEU A  51
ILE A  49
None
1.21A 2bxpA-3bptA:
1.9
2bxpA-3bptA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e10 PUTATIVE NADH
OXIDASE


(Clostridium
acetobutylicum)
PF00881
(Nitroreductase)
5 LEU A  71
ALA A  72
ILE A  73
SER A 142
ALA A 110
None
1.04A 2bxpA-3e10A:
undetectable
2bxpA-3e10A:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eq2 PROBABLE
TWO-COMPONENT
RESPONSE REGULATOR


(Pseudomonas
aeruginosa)
PF00072
(Response_reg)
PF07228
(SpoIIE)
5 LEU A  83
LEU A 114
LEU A  25
ALA A  22
ILE A  10
None
1.24A 2bxpA-3eq2A:
undetectable
2bxpA-3eq2A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdj HEMOGLOBIN SUBUNIT
ALPHA


(Camelus
dromedarius)
PF00042
(Globin)
5 PHE A 128
LEU A 136
HIS A  87
ALA A  79
ALA A  65
None
None
HEM  A 142 (-3.5A)
None
HEM  A 142 ( 3.8A)
0.94A 2bxpA-3gdjA:
2.4
2bxpA-3gdjA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gxu EPHRIN TYPE-A
RECEPTOR 4


(Homo sapiens)
PF01404
(Ephrin_lbd)
5 PHE A 153
LEU A  96
PHE A  94
LEU A 155
SER A 168
None
1.21A 2bxpA-3gxuA:
undetectable
2bxpA-3gxuA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h8w RIBONUCLEASE H

(Escherichia
virus T4)
PF02739
(5_3_exonuc_N)
PF09293
(RNaseH_C)
5 LEU A 115
LEU A  68
ILE A  18
SER A  21
ALA A  24
None
1.14A 2bxpA-3h8wA:
undetectable
2bxpA-3h8wA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdy UDP-GALACTOPYRANOSE
MUTASE


(Deinococcus
radiodurans)
PF03275
(GLF)
PF13450
(NAD_binding_8)
5 LEU A 387
LEU A  48
ALA A  45
ILE A  34
ALA A 380
None
1.13A 2bxpA-3hdyA:
undetectable
2bxpA-3hdyA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2k EHPF

(Pantoea
agglomerans)
PF00501
(AMP-binding)
5 LEU A 198
LEU A 216
LEU A 213
ILE A 233
ALA A 138
None
1.03A 2bxpA-3l2kA:
undetectable
2bxpA-3l2kA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1l 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE


(Mycobacterium
tuberculosis)
PF13561
(adh_short_C2)
5 LEU A 102
PHE A 106
LEU A 141
LEU A 160
ALA A 159
None
1.05A 2bxpA-3m1lA:
undetectable
2bxpA-3m1lA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mos TRANSKETOLASE

(Homo sapiens)
PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
5 TRP A 211
PHE A 228
LEU A 182
ALA A  44
ILE A  47
None
1.13A 2bxpA-3mosA:
undetectable
2bxpA-3mosA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mq3 PYRUVATE
DEHYDROGENASE
PHOSPHATASE 1


(Bos taurus)
PF00481
(PP2C)
5 PHE A  72
LEU A 165
ALA A 164
SER A  95
ALA A  93
None
1.09A 2bxpA-3mq3A:
undetectable
2bxpA-3mq3A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8o 6-PHOSPHOFRUCTOKINAS
E SUBUNIT ALPHA


(Saccharomyces
cerevisiae)
PF00365
(PFK)
5 LEU A 571
LEU A 407
ALA A 406
ILE A 418
ALA A 412
None
1.11A 2bxpA-3o8oA:
undetectable
2bxpA-3o8oA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rpw ABC TRANSPORTER

(Rhodopseudomonas
palustris)
PF13416
(SBP_bac_8)
5 LEU A 118
LEU A 285
LEU A 281
ILE A 105
ALA A 132
None
1.12A 2bxpA-3rpwA:
undetectable
2bxpA-3rpwA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tac LIPRIN-ALPHA-2

(Homo sapiens)
PF00536
(SAM_1)
PF07647
(SAM_2)
5 LEU B1063
LEU B1054
LEU B1051
ALA B1048
ILE B1024
None
1.24A 2bxpA-3tacB:
undetectable
2bxpA-3tacB:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tad LIPRIN-ALPHA-2

(Homo sapiens)
PF00536
(SAM_1)
PF07647
(SAM_2)
5 LEU A1063
LEU A1054
LEU A1051
ALA A1048
ILE A1024
None
1.25A 2bxpA-3tadA:
undetectable
2bxpA-3tadA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3teh PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN


(Thermus
thermophilus)
PF01409
(tRNA-synt_2d)
5 LEU A 244
PHE A 245
LEU A 110
LEU A 317
ALA A 323
None
1.15A 2bxpA-3tehA:
undetectable
2bxpA-3tehA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tij NUPC FAMILY PROTEIN

(Vibrio cholerae)
PF01773
(Nucleos_tra2_N)
PF07662
(Nucleos_tra2_C)
PF07670
(Gate)
5 LEU A 406
LEU A 403
ALA A 400
ILE A 399
ALA A 367
None
None
None
DMU  A 424 ( 4.7A)
None
1.24A 2bxpA-3tijA:
undetectable
2bxpA-3tijA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u12 USP37 PROTEIN

(Homo sapiens)
PF16674
(UCH_N)
5 LEU A  38
LEU A  74
LEU A  72
ALA A  92
ILE A   6
None
None
None
None
UNX  A1019 ( 4.3A)
1.09A 2bxpA-3u12A:
undetectable
2bxpA-3u12A:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vb0 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE


(Sphingomonas
wittichii)
PF00903
(Glyoxalase)
5 TRP A  67
LEU A   9
PHE A  11
LEU A 145
LEU A 212
None
1.17A 2bxpA-3vb0A:
undetectable
2bxpA-3vb0A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wib HALOALKANE
DEHALOGENASE


(Agrobacterium
fabrum)
PF00561
(Abhydrolase_1)
5 PHE A 243
LEU A 239
LEU A 288
ALA A 285
ILE A 284
None
1.04A 2bxpA-3wibA:
undetectable
2bxpA-3wibA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2q RETINOIC ACID
INDUCIBLE PROTEIN I


(Anas
platyrhynchos)
PF00270
(DEAD)
PF00271
(Helicase_C)
PF16739
(CARD_2)
5 LEU A  57
LEU A  20
LEU A  84
ALA A  85
ILE A  88
None
0.95A 2bxpA-4a2qA:
3.5
2bxpA-4a2qA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c90 ALPHA-GLUCURONIDASE
GH115


(Bacteroides
ovatus)
PF15979
(Glyco_hydro_115)
5 PHE A  34
LEU A  46
LEU A 160
LEU A  72
ALA A  69
None
1.12A 2bxpA-4c90A:
undetectable
2bxpA-4c90A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvc ALCOHOL
DEHYDROGENASE


(Pseudogluconobacter
saccharoketogenes)
PF13360
(PQQ_2)
5 ARG A 438
LEU A 456
ALA A 496
ILE A 497
ALA A 443
None
1.12A 2bxpA-4cvcA:
undetectable
2bxpA-4cvcA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dol AT1G53520

(Arabidopsis
thaliana)
PF02431
(Chalcone)
5 PHE A  88
LEU A  70
LEU A 216
ALA A 213
ILE A  81
None
1.23A 2bxpA-4dolA:
undetectable
2bxpA-4dolA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h2l ALPHA-GLOBIN

(Peromyscus
maniculatus)
PF00042
(Globin)
5 PHE A 128
LEU A 136
HIS A  87
ALA A  79
ALA A  65
None
None
HEM  A 201 (-3.4A)
None
HEM  A 201 ( 3.8A)
0.97A 2bxpA-4h2lA:
2.5
2bxpA-4h2lA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h3t CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY


(Acidimicrobium
ferrooxidans)
PF09481
(CRISPR_Cse1)
5 LEU A  15
PHE A  42
LEU A  29
LEU A  60
ALA A  59
None
1.10A 2bxpA-4h3tA:
2.4
2bxpA-4h3tA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4icq AMINOPEPTIDASE PEPS

(Streptococcus
pneumoniae)
PF02073
(Peptidase_M29)
5 PHE A 341
TRP A 154
LEU A  17
ALA A  14
ILE A  45
None
1.21A 2bxpA-4icqA:
undetectable
2bxpA-4icqA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mbg CAAX
FARNESYLTRANSFERASE
BETA SUBUNIT RAM1


(Aspergillus
fumigatus)
PF00432
(Prenyltrans)
5 LEU B 491
LEU B 124
HIS B 129
LEU B 411
ALA B 437
None
0.90A 2bxpA-4mbgB:
undetectable
2bxpA-4mbgB:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mfz DBV8 PROTEIN

(Nonomuraea
gerenzanensis)
no annotation 5 LEU A  99
PHE A 110
LEU A  12
LEU A  20
ALA A  70
None
1.18A 2bxpA-4mfzA:
undetectable
2bxpA-4mfzA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mh1 SORBOSE
DEHYDROGENASE


(Ketogulonicigenium
vulgare)
PF13360
(PQQ_2)
5 ARG A 385
LEU A 403
ALA A 443
ILE A 444
ALA A 390
None
1.15A 2bxpA-4mh1A:
undetectable
2bxpA-4mh1A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mnr PEPTIDOGLYCAN
GLYCOSYLTRANSFERASE


(Eggerthella
lenta)
PF00905
(Transpeptidase)
5 LEU A 271
PHE A 269
LEU A 110
ALA A 141
ILE A 139
None
1.13A 2bxpA-4mnrA:
undetectable
2bxpA-4mnrA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nmn REPLICATIVE DNA
HELICASE


(Aquifex
aeolicus)
PF00772
(DnaB)
PF03796
(DnaB_C)
5 LEU A 217
LEU A 243
LEU A 286
ILE A 284
ALA A 314
None
1.02A 2bxpA-4nmnA:
undetectable
2bxpA-4nmnA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oun MINI-RIBONUCLEASE 3

(Bacillus
subtilis)
PF00636
(Ribonuclease_3)
5 LEU A 129
PHE A  46
LEU A  85
ILE A  81
ALA A 146
None
0.96A 2bxpA-4ounA:
undetectable
2bxpA-4ounA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0e MAF-LIKE PROTEIN
YHDE


(Escherichia
coli)
PF02545
(Maf)
5 LEU A  17
LEU A   4
LEU A 109
ALA A 108
ALA A   7
None
1.12A 2bxpA-4p0eA:
undetectable
2bxpA-4p0eA:
15.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus)
PF00273
(Serum_albumin)
5 LEU A 219
PHE A 223
LEU A 238
HIS A 242
LEU A 260
None
0.55A 2bxpA-4po0A:
40.4
2bxpA-4po0A:
74.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4po0 SERUM ALBUMIN

(Oryctolagus
cuniculus)
PF00273
(Serum_albumin)
6 TRP A 214
LEU A 219
PHE A 223
HIS A 242
LEU A 260
ALA A 261
None
0.43A 2bxpA-4po0A:
40.4
2bxpA-4po0A:
74.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q38 PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24


(Actinoplanes
teichomyceticus)
no annotation 5 LEU A  99
PHE A 110
LEU A  12
LEU A  20
ALA A  70
None
1.21A 2bxpA-4q38A:
undetectable
2bxpA-4q38A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r10 PROTEIN HUMPBACK-2

(Caenorhabditis
elegans)
PF00514
(Arm)
5 LEU A 232
LEU A 165
ALA A 166
ILE A 169
ALA A 203
None
0.58A 2bxpA-4r10A:
undetectable
2bxpA-4r10A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u8f PUTATIVE
UNCHARACTERIZED
PROTEIN GBS1892


(Streptococcus
agalactiae)
PF02502
(LacAB_rpiB)
PF12408
(DUF3666)
5 LEU A 134
PHE A 135
ALA A   4
ILE A   3
ALA A 110
None
1.15A 2bxpA-4u8fA:
undetectable
2bxpA-4u8fA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uj8 SURFACE LAYER
PROTEIN


(Geobacillus
stearothermophilus)
no annotation 5 PHE A 863
LEU A 816
LEU A 787
ALA A 784
ILE A 846
None
1.10A 2bxpA-4uj8A:
undetectable
2bxpA-4uj8A:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xkj D-LACTATE
DEHYDROGENASE


(Sporolactobacillus
inulinus)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
5 LEU A 203
LEU A 229
LEU A 243
ALA A 242
ALA A 219
None
1.16A 2bxpA-4xkjA:
undetectable
2bxpA-4xkjA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdn AT-LESS POLYKETIDE
SYNTHASE


(Streptomyces
platensis)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
5 LEU A 912
LEU A 557
LEU A 799
ALA A 749
ALA A 796
None
1.15A 2bxpA-4zdnA:
undetectable
2bxpA-4zdnA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa5 NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK


(Cupriavidus
necator)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C)
5 LEU A  93
LEU A 129
LEU A 168
ALA A 165
ALA A 146
None
1.16A 2bxpA-5aa5A:
undetectable
2bxpA-5aa5A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b2o CRISPR-ASSOCIATED
ENDONUCLEASE CAS9


(Francisella
tularensis)
no annotation 5 LEU A  12
LEU A 869
ALA A 870
ILE A 873
ALA A1096
None
1.02A 2bxpA-5b2oA:
1.7
2bxpA-5b2oA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp7 SAM-DEPENDENT
METHYLTRANSFERASE


(Geobacter
sulfurreducens)
PF13847
(Methyltransf_31)
5 TRP A 241
LEU A  29
LEU A  33
ILE A 136
ALA A 109
None
1.23A 2bxpA-5bp7A:
undetectable
2bxpA-5bp7A:
18.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus)
PF00273
(Serum_albumin)
9 TRP A 213
LEU A 218
PHE A 222
LEU A 237
HIS A 241
LEU A 259
ALA A 260
ILE A 263
ALA A 290
None
None
None
PG4  A 602 (-4.7A)
PG4  A 602 (-4.0A)
PG4  A 602 ( 4.5A)
PG4  A 602 ( 3.9A)
None
PG4  A 602 (-3.4A)
0.56A 2bxpA-5dqfA:
41.4
2bxpA-5dqfA:
76.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus)
PF00273
(Serum_albumin)
9 TRP A 213
LEU A 218
PHE A 222
LEU A 237
HIS A 241
LEU A 259
ILE A 263
SER A 286
ALA A 290
None
None
None
PG4  A 602 (-4.7A)
PG4  A 602 (-4.0A)
PG4  A 602 ( 4.5A)
None
PG4  A 602 (-3.9A)
PG4  A 602 (-3.4A)
0.71A 2bxpA-5dqfA:
41.4
2bxpA-5dqfA:
76.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9a BETA-GALACTOSIDASE

(Rahnella sp. R3)
PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C)
5 LEU A 339
PHE A 641
LEU A 390
ALA A 397
ALA A 346
None
1.10A 2bxpA-5e9aA:
undetectable
2bxpA-5e9aA:
21.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus)
PF00273
(Serum_albumin)
9 PHE A 211
TRP A 214
LEU A 219
PHE A 223
LEU A 238
HIS A 242
LEU A 260
ALA A 261
ALA A 291
None
0.36A 2bxpA-5ghkA:
38.3
2bxpA-5ghkA:
79.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ghk SERUM ALBUMIN

(Canis lupus)
PF00273
(Serum_albumin)
9 PHE A 211
TRP A 214
LEU A 219
PHE A 223
LEU A 238
HIS A 242
LEU A 260
SER A 287
ALA A 291
None
0.59A 2bxpA-5ghkA:
38.3
2bxpA-5ghkA:
79.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdx METALLOPEPTIDASE

(Pseudomonas
aeruginosa)
PF13402
(Peptidase_M60)
5 LEU A 349
LEU A  70
ALA A  67
ILE A 310
ALA A 379
None
1.17A 2bxpA-5kdxA:
1.2
2bxpA-5kdxA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kkg ANCMT E72A

(synthetic
construct)
PF04587
(ADP_PFK_GK)
5 LEU A 366
LEU A 109
LEU A 106
ALA A 103
ILE A 102
None
1.01A 2bxpA-5kkgA:
undetectable
2bxpA-5kkgA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE DELTA
SUBUNIT


(Aromatoleum
aromaticum)
PF02538
(Hydantoinase_B)
5 LEU A 295
PHE A 343
ALA A 315
ILE A 314
ALA A 308
None
1.16A 2bxpA-5l9wA:
undetectable
2bxpA-5l9wA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m0y CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION


(Ruminiclostridium
thermocellum)
PF00963
(Cohesin)
5 LEU A 161
PHE A  48
ALA A 130
ILE A 129
ALA A 108
None
1.05A 2bxpA-5m0yA:
undetectable
2bxpA-5m0yA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5me3 SISTER CHROMATID
COHESION PROTEIN 2


(Eremothecium
gossypii)
PF12765
(Cohesin_HEAT)
PF12830
(Nipped-B_C)
5 LEU A 801
LEU A 852
ALA A 849
ILE A 848
ALA A 794
None
1.10A 2bxpA-5me3A:
undetectable
2bxpA-5me3A:
19.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus)
no annotation 8 ARG A 217
LEU A 218
PHE A 222
LEU A 237
LEU A 259
ALA A 260
ILE A 263
ALA A 290
None
0.81A 2bxpA-5oriA:
40.2
2bxpA-5oriA:
74.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus)
no annotation 8 LEU A 218
PHE A 222
LEU A 237
HIS A 241
LEU A 259
ALA A 260
ILE A 263
ALA A 290
None
0.61A 2bxpA-5oriA:
40.2
2bxpA-5oriA:
74.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ori ALBUMIN

(Capra hircus)
no annotation 8 LEU A 218
PHE A 222
LEU A 237
HIS A 241
LEU A 259
ILE A 263
SER A 286
ALA A 290
None
0.79A 2bxpA-5oriA:
40.2
2bxpA-5oriA:
74.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t0z LIPOPROTEIN,
PUTATIVE


(Geobacter
metallireducens)
no annotation 5 ARG A  73
LEU A  39
LEU A 167
ILE A 171
ALA A  61
None
0.94A 2bxpA-5t0zA:
undetectable
2bxpA-5t0zA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tgn UNCHARACTERIZED
PROTEIN


(Sphaerobacter
thermophilus)
PF12680
(SnoaL_2)
5 ARG A  97
ALA A  47
ILE A  46
SER A  20
ALA A  24
None
0.99A 2bxpA-5tgnA:
undetectable
2bxpA-5tgnA:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w6l RTX
REPEAT-CONTAINING
CYTOTOXIN


(Vibrio
vulnificus)
no annotation 5 LEU A3598
LEU A3620
HIS A3624
LEU A3638
ILE A3642
LEU  A3598 ( 0.6A)
LEU  A3620 ( 0.6A)
HIS  A3624 ( 1.0A)
LEU  A3638 ( 0.6A)
ILE  A3642 ( 0.7A)
1.05A 2bxpA-5w6lA:
undetectable
2bxpA-5w6lA:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wvg CHITINASE

(Ostrinia
furnacalis)
no annotation 5 PHE A 626
LEU A 634
LEU A 601
ALA A 602
ILE A 603
None
1.15A 2bxpA-5wvgA:
undetectable
2bxpA-5wvgA:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ysm CYTOCHROME P450

(Amycolatopsis
mediterranei)
no annotation 5 LEU A 121
PHE A 106
LEU A 231
LEU A 241
ALA A 250
None
HEM  A 501 (-4.6A)
None
None
None
1.24A 2bxpA-5ysmA:
2.0
2bxpA-5ysmA:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus)
no annotation 7 PHE A 211
TRP A 214
LEU A 219
PHE A 223
LEU A 238
HIS A 242
ILE A 290
None
1.26A 2bxpA-5yxeA:
37.9
2bxpA-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus)
no annotation 9 PHE A 211
TRP A 214
LEU A 219
PHE A 223
LEU A 238
HIS A 242
LEU A 260
ALA A 261
ILE A 264
None
0.50A 2bxpA-5yxeA:
37.9
2bxpA-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxe SERUM ALBUMIN

(Felis catus)
no annotation 9 PHE A 211
TRP A 214
LEU A 219
PHE A 223
LEU A 238
HIS A 242
LEU A 260
ILE A 264
SER A 287
None
0.67A 2bxpA-5yxeA:
37.9
2bxpA-5yxeA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b20 GUANINE
NUCLEOTIDE-BINDING
PROTEIN
G(I)/G(S)/G(T)
SUBUNIT BETA-1


(Bos taurus)
no annotation 5 LEU A 168
PHE A 180
LEU A 152
LEU A 192
ALA A 193
None
1.22A 2bxpA-6b20A:
undetectable
2bxpA-6b20A:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b8a DNA-BINDING
TRANSCRIPTIONAL
REGULATOR


(Pseudomonas
aeruginosa)
no annotation 5 LEU A 285
PHE A 281
LEU A 163
ALA A 146
ILE A 145
None
1.25A 2bxpA-6b8aA:
undetectable
2bxpA-6b8aA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhs ARP5

(Chaetomium
thermophilum)
no annotation 5 PHE J 119
LEU J 136
PHE J 140
ILE J 156
ALA J  70
None
1.24A 2bxpA-6fhsJ:
undetectable
2bxpA-6fhsJ:
8.72